Tobacco Documents Online

-. ( B RO~N & WILL~MSON TOBACCO CORPORATION ER.~F_~r PEI~ PLF..S November 12, 1986 Stan Temko, Esquire Covington & Burlin9 1201 Pennsylvania Avenue, P. O. Box 7566 Washington, DC 20044 Dear Stan: I spoke to you this morning about the massive inhalation study funded over several years by the CTR to look into the effect of whole, fresh cigarette smoke on the lungs of mice. The cost of the study was approximately $13 million. No squamous cell carcinomas were observed in any of the animals. The lead investigator was Richard Kouri. Kouri and his associate, Carol Henry, wrote up the study in a ~ournal in July 1986. I enclose a copy of their article with this letter. We will ask CTR to send you a more extensive report which was privately published by CTR about a year ago. See Leonard Zahn's news release, enclosed herewith, for November 9, 1984. Last week you.mentione~ that an inhalation study'might be appropriate using a package of commonly added flavors to see if it increased biologic activity. The work CTR did may be of some help in this regard. I question the direct applicability of these experimental protocols to the study of cigarettes containing a flavor package, however. Perhaps more "short term" studies would be helpful in preparing for talks with HHS - e.g., following more along the lines of the various approaches described in Section V of the CTR report. These would require fewer animals and shorter exposure periods. The most effective "control" group would be animals receiving the same tobacco type but without the flavoring agent under test. All good wishes. EP/dlb Cordially Enclosures ~ lEO IIR0%%'% • %%'ILLiA~i%ON TOWER FIL,- COPY 282002775 Subject to Claims of Privilege and Confidentiality: Produced Pursuant to Court Orders in State of Minnesota, et al. v. Philip Morris, et al.