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v CONFIDENTIAL: MINNESOTA TOBACCO LITIGATION COPY March 11, 1971 Dr. Paul E. Lacy Dr. Lauren V. Ackerman Department of Pathology Washington University School of Medicine 4550 Scott Avenue St. Louis, Missouri 3110 Gentlemen: The undersigned companies were very pleased to receive from you an application for support for a research program in the field of cancer immunology. We understand that the purpose of the program is to isolate and characterize specific antigens of cancer and to utilize these for the early detection, treatment and possible prevention of cancer in man. We are advised that cancer immunology at present is one of the most promising fields for basic research and it is hoped and expected that from properly directed research in this area it may be possible to identify specific 7 0020690 TIMN 0077242

2. CONFIDENTIAL: MINNESOTA TOBACCO LITIGATION antigens for various types of cancer. You have informed us through your proposal that a specific antigen for cancer of the colon has been identi- fied by Dr. P. Gold and his co-workers in Montreal and that Dr. J. Rosai and his group from Washington University have purified this antigen using another method. We understand that similar tumor-specific antigens from cancer of the lung will be searched for; that it is hoped that serological tests might be developed for screening populations; and that immuno-therapy could be contemplated. We are aware of the facilities and equipment available at Washington University and we believe that the intel- lectual resources that have been developed for the support of this program are superior. Therefore, the undersigned companies are pleased to contribute to Washington University School of Medicine, to finance the program which has been outlined for a five-year period; a total sum of $2,000,000. The contribution of each company participating will be paid in quarter-annual installments of approximately equal amounts. Inasmuch as the contribution is to be used T 00~:0691 TIMN 0077243

1 3. . I CONFIDENTIAL: MINNESOTA TOBACCO LITIGATION only for the specified project, we assume that if any part of the funds is not needed, or cannot be usefully spent for the advancement of this project, that the undersigned companies will be so advised and their respective contri- butions reduced proportionately. We would anticipate receiving periodic progress reports. It is understood that the undersigned companies are to be the sole sponsors of this project; however, you and the Washington University School of Medicine shall have sole control over the conduct of the project. Would you please indicate to each of the undersigned companies if you are agreeable to receiving the proposed contribution for the pursuance of this research program by signing and returning to each of them one of the enclosed duplicate copies of this letter. We wish you success in achieving the objectives of your project and we feel certain that the efforts of your group will contribute importantly to fundamental knowledge concerning cancer in man. (Signed By: ~oooosy'z TIMN 0077244 R. J. Reynolds Tobacco Co., Winston-Salem, N.C.; Brown and Williamson Tobacco Corp., Louisville, Ky.; Philip Morris Inc., New York, N.Y.; Lorillard, a division of Loews Theatres Inc., New York, N.Y.; Liggett and Myers, Inc., New York, N.Y.; Larus and Brother Co. Inc., Richmond, Va.; United States Tobacco Co., Greenwich,• Conn. and Tobacco Associates, Inc.)