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CURRICULUM VITAE JAMES CAMERON HOGG ~

- 2 - CURRICULUM VITAE NAME: HOGG, James Cameron DATE OF BIRTH: December 4, 1935 MARITAL STATUS: • Married to Denise M. Lamoureux, May 21, 1960 Two children - Robert, birth date - May 31, 1961 Karen, birth date - November 26, 1962 CITIZENSHIP: Canadian CERTIFICATES, 1962 - M.D., University of Manitoba DEGREES, 1963 - Diploma U.S. National Board of Medical DIPLOMAS, and Examiners LICENCES: 1963 - L.M.C.C. - Licentiate of the Medical Council of Canada 1967 - M.Sc., McGill University, Montreal 1969 - Ph.D., McGill University, Montreal 1972 - Quebec Licence, 72-666 1974 - F.R.C.P.(C) 1977 - College of Physicians and Surgeons of B.C. Licence #716 TRAINING: 1962-63 Rotating Internship, Winnipeg General Hospital, Winnipeg, Manitoba 1963-65 General Medical Officer, Royal Canadian Air Force, Greenwood, Nova Scotia 1965-66 Physiologist, Royal Canadian Air Force 1966-69 Post-doctoral Research Fellow, Me ical Research Council of Canada, Departm~nts of Pathology and Experimental Medicine, McGill University, Montreal 1969-70 Assistant Resident, Anatomical Pathology, Massachusetts General Hospital, Boston, Mass. 1970-71 Assistant Resident, Anatomical Pathology, Pathology Institute, McGill University Montreal 1987-88 Visiting Research Fellow, Merton College, Oxford (Molecular Biology)

3 PREVIOUS POSITIONS: 1971-72 Assistant Professor, Departments of 1972-75 Pathology and Experimental Medicine, McGill University, Montreal Assistant Pathologist, Royal Victoria 1972-75 Hospital, Montreal Associate Professor, Department of 1975-77 Pathology, McGill University, Montreal Miranda Fraser Professor of Pathology, PRESENT POSITIONS: 1977- McGill University, Montreal Professor, Department of Pathology, OSPITAL AND 973-76 University of British' Columbia, and Director of the Pulmonary Research Laboratory, St. Paul's Hospital, Vancouver Co-Chairman, Biology of Disease - a multi- ACADEMIC ADMINIS- disciplinary course of 350 hours sponsored TRATIVE POSITIONS: by the Departments of Pathology, Micro- 1980- biology, Epidemiology and Pharmacology, McGill University, Montreal Research Co-ordinator, and Chairman, 1985- Research Co-ordinating Committee, St. Paul's Hospital, Vancouver Member, Medical Advisory Committee, St. 1988- Paul's Hospital, Vancouver Member, Planning and Priorities Committee, St. Paul's Hospital, Vancouver / 1989- Member, Natural, Applied and Health Sciences 1989- Research Board, University of British Columbia: Executive Committee for Research Member, Task Force on Promotion of Health HONOURS. AWARDS and 1975-76 Care Research, Council of University Teaching Hospitals Member, Research Review Committee, American EXECUTIVE POSITIONS IN Thoracic Society SCIENTIFIC ASSOCIATIONS: 1975-76 Member, Scientific Review Committee, Canadian Thoracic Society

4 1975-76 Member, National Institutes of Health Review Committee, Specialized Centers for Research 1976-80 Member, Pathology Study Section A, National Institutes of Health, U.S. Public Health Service 1976-79 Councillor, American Lung Association 1977- Member, Scientific Review Committee, Canadian Heart Foundation 1977-84 Member, Board of Directors, Canadian Thoracic Society 1979-80 President, Section on Pulmonary Circulation, American Thoracic Society 1979-86 Member, Heart and Lung Committee, Medical Research Council of Canada 1979-83 Member, Scholarship Committee, 1981-83 Chairman, Scholarship Committee, 1980-83 Member, Scientific Advisory Committee B.C. Health Care Research Foundation 1979-82 Consultant, Laboratory Advisory Council Equipment Sub-Committee, Ministry of Health, Province of British Columbia 1980-82 Corresponding Member, Specialty Committee in Respiratory Medicine, Royal College of Physicians and Surgeons of Canada 1980-83 Council Member, Canadian Society fog Clinical Investigation Member, Membership Committee 1981-82 President Elect, Canadian Thoracic Society 1982-83 President, Canadian Thoracic Society 1981-89 Member-at-Large, National Cancer Institute of Canada 1986- Member, Heart/Lung Subcommittee of the Professional Advisory Committee, British Columbia Transplant Society 1987- Member, Council of Scientific Advisors, nJi Parker B. Francis Foundation w

5 1987 Izaak Walton Killam Research Prize University of British Columbia 1989- Member, Scholarship Advisory Committee, Alberta Heritage Foundation 1989- Member, Research Advisory Committee, British Columbia Ministry of Health 1990- Secretary, Canadian Institute of Academic Medicine EDITORIAL BOARDS: 1978-83 Member, Editorial Board, Laboratory investigation 1980- Member, Editorial Board, Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology 1982-88 Member, Editorial Board, American Review of Respiratory Disease 1984- Member, Editorial Board, Respiration 1987- Member, Editorial Board, Pulmonary Pharmacology 1989-90 Member, Editorial Board, Pulmonary Perspectives ~

6 MEMBERSHIP IN SCIEN- TIFIC ASSOCIATIONS: 1972- American Association of Pathologists and 1972- Bacteriologists: Regular Member American Society of Experimental Pathology: Regular Member 1972- American Physiological Society: Regular Member 1972- Canadian Society for Clinical Investigation: Regular Member 1973- Canadian Association of Pathologists: Regular Member 1973- Canadian Thoracic Society: Regular Member 1973- American Thoracic Society: Regular Member 1974- Fleischner Society: Regular Member 1986-87 Chairman, Membership Committee 1989-91 Chairman, Scientific Program Committee 1974- American Society for Clinical 1974- Investigation: Regular Member Pluto Club: Regular Member 1979- Member, Western Association of Physicians 1986- Member, Association of American Physicians 1989- Member, Organizing Council, Canadian 1990- Institute of Academic Medicine ~ Secretary 1988- Member, Steering Committee, Asian Pacific Society of Respirology

BIBLIOGRAPHY - Publications in Reviewed Journals 1. Hogg, J.C.: A comparison of questionnaire to physical examination in assessing the health of 67 individuals at R.C.A.F. Greenwood. Med. Serv. J. Can. 21: 263-268, 1965. 2. Hogg, J.C.: Subclinical coronary artery disease at R.C.A.F. Greenwood. Med. Serv. J. Can. 22: 799-806, 1966. 3. Hogg, J.C., Macklem, P.T., and Thurlbeck, W.M.: Site and nature of airway obstruction in chronic obstructive lung disease. N.E.J.M. 278: 1355-1360, 1968. 4. Hogg, J.C., Macklem, P.T., and Thurlbeck, W.M.: The resistance of collateral channels in excised human lungs. J. Clin. Invest. 48: 421-431, 1969. 5. Hogg, J.C., Nepszy, S., Macklem, P.T., and Thurlbeck, W.M.: The elastic properties of the centrilobular emphysematous space. J. Clin. Invest. 48: 1306-1312, 1969. 6. Cooperman, E.M., Hogg, J.C., and Thurlbeck, W.M.: Mechanisms of death in shallow-water scuba diving. Can. Med. Assoc. J. 99: 1128-1131, 1968. 7. Hogg, J.C., and Nepszy, S.: Regional lung volume and the pleural pressure gradient in dogs. J. Appl. Physiol. 27: 198-203, 1969. 8. Macklem, P.T., Woolcock, A.J., Hogg, J.C., Nadel, J.A., and Wilson, N.J.: Partitioning of pulmonary resistance in the dog. J. Appl. Physiol. 26: 798-805, 1969. 9. Woolcock, A.J., Macklem, P.T., Hogg, J.C., Wilson, N.J., Nadel, J.A., Frank, N.R., and Brain, J.: Effect of vagal stimulation on the central and peripheral airways in dogs. J. Appl. Physiol. 26: 806-813, 1969. 10. Woolcock, A.J., Macklem, P.T., Hogg, J.C. and Wilson, N.J.: Influence of the autonomic nervous system on airway resistance and elastic recoil. J. Appl. Physiol. 26: 814-818, 1969. 11. Agarwal, J., Hogg, J.C., and Palmer, W.F.: The effect of hypertonic saline on pulmonary vascular resistance in dogs. Cardiovascular Res. 3: 459-466, 1969. 12. Macklem, P.T., Proctor, D.F., and Hogg, J.C.: The stability of peri- pheral airways. Resp. Physiol. 8: 191-203, 1970. 13. Katsura, T., Rozencwajg, R., Sutherland, P.W., Hogg, J.C., and Milic- Emili, J.: Effect of external support on regional alveolar expansion in excised dog lung. J. Appl. Physiol. 28: 133-137, 1970.

8 14. Hogg, J.C., Williams, J., Richardson, J.B., Macklem, P.T., and Thurlbeck, W.M.: Age as a factor in the distribution of lower airway conductance and in the pathologic anatomy of obstructive lung disease. N.E.J.M. 282: 1283-1287, 1970. 15. Pushpakom, R., Hogg, J.C., Woolcock, A.J., Angus, C.E., Macklem, P.T., and Thurlbeck, W.Ms: Experimentally induced papain emphysema in dogs. Am. Rev. Respir. Dis. 102: 778-789, 1970. 16. Hogg, J.C., Holst, P., Corry, P., Ruff, F., Houseley, E., and Morris, E.: The effect of regional lung expansion and body position on pulmonary per- fusion in dogs. J. Appl. Physiol. 31: 97-101, 1971. 17. Schleusener, A., Hogg, J.C., and Thurlbeck, W.M.: Untersuchungen der kleinen Luftwege beim Emphysem (Measurements of small airways in emphysema). Pneumonologie 144: 33-38, 1971. 18. Hogg, J.C., Agarwal, J.B., Gardiner, A.J.S., Palmer, W.H. and Macklem, P.T.: Distribution of airways resistance with developing pulmonary edema in dogs. J. Appl. Physiol. 32: 20-24, 1972. 19. Muir, A.L., Hall, D.L., Despas, P., and Hogg, J.C.: The distribution of blood flow in acute pulmonary edema in dogs. J. Appl. Physiol. 33: 763-769, 1972. 20. Robertson, C.H., Hall, D.L., and Hogg, J.C.: A description of lung distortion due to localized pleural stress. J. Appl. Physiol. 34: 344-350, 1973. 21. Richardson, J.B., Hogg, J.C., Bouchard, T., and Hall, D.L.: Local- ization of antigen in experimental bronchoconstriction in guinea pigs. J. Allergy Clin. Immunol. 52: 172-181, 1973. 22. Simani, A.S., Inoue, S., and Hogg, J.C.: Penetration of respiratory epithelium of guinea pigs following exposure to cigarette smoke.' Lab. Invest. 31: 75-81, 1974. 23. Inoue, S., and Hogg, J.C.: Intercellular junctions of the tracheal epithelium in guinea pigs. Lab. Invest. 31: 68-74, 1974. 24. Moroz, L.A., Joubert, J.J., and Hogg, J.C.: A potent non-peroxidase glycoprotein immunogen in commercial horseradish peroxidase. J. Immunol. 112: 1094-1099, 1974. 25. Coates, A.L., Hogg, J.C., and Thurlbeck, W.M.: Protection against barbi- turate anesthesia death in rabbits. Br. J. Exp. Path. 55: 228-232, 1974. 26. Sureete, G.D., Muir, A.L., Hogg, J.C., and Fraser, R.G.: Roentgeno- graphic study of blood flow redistribution in acute pulmonary edema. Invest. Radiol. 10: 109-114, 1975.

9 27. Joubert; J., Hogg, J.C., and Moroz, L.A.: Rabbit homocytotropic antibody response to horseradish peroxidase: The role of contaminating antigens. Immunochemistry 12: 973-974, 1975. 28. Muir, A.L., Hogg, J.C., Naimark, A., Hall, D.L., and Chernecki, W.: The effect of alveolar liquid on the distribution of blood flow in dog lungs. J. Appl. Physiol. 39: 885-890, 1975. 29. Zamel, N., Hogg, J.C., and Gelb, A.: Mechanisms of maximum expiratory flow limitation in clinically unsuspected emphysema and small airways obstruction. Am. Rev. Respir. Dis. 113: 337-345, 1976. 30. Joubert, J.R., Ascah, K., Moroz, L.A., and Hogg, J.C.: Acute hyper- sensitivity pneumonitis in the rabbit. I. An animal model with horse- radish peroxidase as antigen. Am. Rev. Respir. Dis. 113: 503-513, 1976. 31. Michoud, M.-C., Fraser, R.S., Pare, P.D., and Hogg, J.C.: Effect of indomethacin and atropine in experimental asthma in conscious guinea pigs. J. Appl. Physiol. 40: 889-894, 1976. 32. Hogg, J.C., Stein, L., Martin, R., and Macklem, P.T.: The interaction of the lung and chest wall in dogs. Respiration Physiology, 27: 207-221, 1976. 33. Inoue, S., Michel, R.P., and Hogg, J.C.: Zonulae occludentes in alveolar epithelium and capillary endothelium of dog lung studied with the freeze-fracture technique. J. Ultrastructure Res. 56: 215-225, 1976. 34. Pare, P.D., Michoud, M.-C., and Hogg, J.C.: Lung mechanics following antigen challenge of Ascaris suum-sensitive monkeys. J. Appl. Physiol. 41: 668-676, 1976. 35. Stein, L.A., Vidal, J.J., Hogg, J.C., and Fraser, R.G.: Acute lobar collapse in canine lungs. Invest. Radiol. 11: 518-527, 1976. 36. Michel, R.P., Inoue, S., and Hogg, J.C.: Pulmonary capillary perl&e- ability in HRP in dogs: A physiologic and morphologic study. J. Appl. Physiol. 42: 13-27, 1977. 37. Pare, P.D., Boucher, R.C., Michoud, M.-C., and Hogg, J.C.: Static lung mechanics of intact and excised rhesus monkey lungs and lobes. J. Appl. Physiol. 44: 547-552, 1978. 38. Boucher, R.C., Pare, P.D., Gilmore, N., Moroz, L.A., and Hogg, J.C.: Airway mucosal permeability in the Ascaris suum-sensitive rhesus monkey. J. Allergy Clin. Immunol. 60: 134-140, 1977. 39. Bilimoria, M.H., Johnson, J., Hogg, J.C., and Witschi, H.P.: Activation of 2-aminoanthracene to mutagenic intermediates by guinea pig and rat microsomal enzymes following tobacco smoke inhalation. Toxicol. Appl. Pharmacol. 41: 119-122, 1977.

40. Bilimoria, M.N., Johnson, J., Hogg, J.C., and Witschi, H.P.: Pulmonary aryl hydrocarbon hydroxylase: Tobacco smoke-exposed guinea pigs. Toxicol. Appl. Pharmacol. 41: 433-440, 1977. 41. Barrios, R., Inoue, S., and Hogg, J.C.: Intercellular junctions in "shock lung": A freeze-fracture study. Lab. Invest. 36: 628-635, 1977. 42: Inoue, S., and Hogg, J.C.: Freeze-etch study of the tracheal epithelium of normal guinea pigs with particular reference to intercellular junctions. J. Ultrastructure Research, 61: 89-99, 1977. 43. Cosio, M., Ghezzo, H., Hogg, J.C., Corbin, R., Loveland, M., Dosman, J., and Macklem, P.T.: The relationship between structural changes in small airways and pulmonary function tests. N.E.J.M. 298: 1277-1281, 1978. 44. Todd, R.J., Baile, E.M., and Hogg, J.C.: Pulmonary_ arterial wedge pressure in hemorrhagic shock. Am. Rev. Respir. Dis. 118: 613-616, 1978. 45. Todd, R.J., Baile, E.M., and Hogg, J.C.: Pulmonary capillary perme- ability during hemorrhagic shock. J. Appl. Physiol. 45: 298-306, 1978. 46. Michoud, M.-C., Pare, P.D., Boucher, R.C., and Hogg, J.C.: Airway responses to histamine and methacholine in Ascaris suum-allergic rhesus monkeys. J. Appl. Physiol. 45: 846-851, 1978. 47. Boucher, R.C., Ranga, V., Pare, P.D., Inoue, S., Moroz, L.A., and Hogg, J.C.: Effect of histamine and methacholine on guinea pig tracheal permeability to HRP. J. Appl. Physiol. 45: 939-948, 1979. 48. Pare, P.D., Michoud, M.-C., Boucher, R.C., and Hogg, J.C.: Pulmonary effects of acute and chronic antigen exposure of immunized guinea pigs. J. Appl. Physiol. 46: 346-353, 1979. 49. Baile, E.M., Pare, P.D., Dahlby, R.W., and Hogg, J.C.: Regional distri- bution of extravascular water and hematocrit in the lung. J. ;ppl. Physiol. 46: 937-942, 1979. 50. Michoud, M.-C., Pare, P.D., Orange, R.P., and Hogg, J.C.: Airway sensi- tivity to slow-reacting substance of anaphylaxis, histamine and antigen in Ascaris sensitivity monkeys. Am. Rev. Respir. Dis. 119: 419-424, 1979. 51. Guerzon, G.M., Pare, P.D., Michoud, M.-C., and Hogg, J.C.: The number and distribution of mast cells in monkey lungs. Am. Rev. Respir. Dis. 119: 59-66, 1979. 52. Pare, J.A.P., Fraser, R.G., Hogg, J.C., Howlett, J.G., and Murphy, S.B.: Pulmonary 'mainline' granulomatosis: Talcosis of intravenous methadone abuse. Medicine 58: 229-239, 1979. 53. Boucher, R.C., Pare, P.D., and Hogg, J.C.: The relationship between air- way hyperreactivity and hyperpermeability in the Ascaris suum-sensitive rhesus monkey. J. Allergy and Clin. Immunol. 64: 197-201, 1979.

54. Hogg, J.C.: Structure and function of small airways. Chest 775: 279-282, 1980. 55. Boucher, R.C., Johnson, J., Inoue, S., Hulbert, W., and Hogg, J.C.: The effect of cigarette smoke on the permeability of guinea pig airways. Lab. Invest. 43: 94-100, 1980. 56. Hicken, P., Hogg, J.C., and Pare, P.D.: Experimental pulmonary arteritis. Invest. Radiol. 15: 299-307, 1980. 57. Hulbert, W., Walker, D.C., Jackson, A., and Hogg, J.C.: Airway perme- ability to horseradish peroxidase in guinea pigs: The repair phase after injury by cigarette smoke. Am. Rev. Respir. Dis. 123: 320-326, 1981. 58. Martin, B.A., Dahlby, R., Nicholls, I., and Hogg, J.C.: Platelet seques- tration in the lung with hemorrhagic shock and reinfusion in dogs. J. Appl. Physiol. 50: 1306-1312, 1981. 59. Michel, R.P., Laforte, M. and Hogg, J.C.: Physiology and morphology of pulmonary microvascular injury with shock and reinfusion. J. Appl. Physiol. 50: 1227-1235, 1981. 60. Jeffries, E., Pare, P.D., and Hogg, J.C.: Measurement of airways edema in allergic bronchoconstriction in the guinea pig. Am. Rev. Respir. Dis. 123: 687-688, 1981. 61. Murphy, K.C., Atkins, C.J., Offer, R.C., Hogg, J.C., and Stein, H.C.: Obliterative bronchiolitis in two patients with rheumatoid arthritis on penicillamine. Arthritis and Rheumatism 24: 120-131, 1981. 62. Staub, N.C., and Hogg, J.C.: Clinical measurement of lung water content. Chest 79: 3-4, 1981. 63. Hulbert, W.C., Walker, D.C., and Hogg, J.C.: The site of leukocyte migration through the tracheal mucosa in the guinea pig. Am. IRev. Respir. Dis. 124: 310-316, 1981. 64. Baile, E.M., Pare, P.D., Brooks, L.A., and Hogg, J.C.: The relationship between regional lung volume and regional pulmonary vascular resistance. J. Appl. Physiol. 52: 914-919, 1982. 65. Martin, B.A., Wright, J.L., Thommasen, H., and Hogg, J.C.: The effect of pulmonary blood flow on the exchange between the circulating and margi- nating pool of polymorphonuclear leukocytes (PMN) in dog lungs. J. Clin. Invest. 69: 1277-1288, 1982. 66. Baile, E.M., Wright, J.L., Pare, P.D. and Hogg, J.C.: The effect of acute small airways inflammation on pulmonary function in dogs. Am. Rev. Respir. Dis. 126: 298-301, 1982. 67. Chan, N.H., Boyko, W.J., Schellenberg, R.R., Copland, G.M. and Hogg, J.C.: A case of eosinophilic pneumonia - with an unusual immune complex vascu- litis in the skin. Chest 82: 113-115, 1982.

- 12 - 68. Pare, P:D., Brooks, L.A., Bates, J., Lawson, L.M., Nelems, J.M., Wright, J.L. and Hogg, J.C.: Exponential analysis of the lung pressure- volume curve as a predictor of pulmonary emphysema. Am. Rev. Respir. Dis. 126: 54-61, 1982. 69. Wright, J.L., Lawson, L., Pare, P.D., Wiggs, B. and Hogg, J.C.: The morphology of peripheral airways in current and ex-smokers. Am. Rev. Respir. Dis. 127: 474-477, 1983. 70. Pare, P.D., Warriner, C.B., Baile, E.M. and Hogg, J.C.: Redistribution of pulmonary extravascular water with positive end-expiratory pressure in canine pulmonary edema. Am. Rev. Respir. Dis. 127: 590-593, 1983. 71. Pare, P.D., Chan-Yan, C., Wass, H., Hooper, R. and Hogg, J.C.: Portal and pulmonary hypertension with microangiographic hemolytic anemia. Am. J. Med. 74: 1093-1096, 1983. - 72. Churg, A., Golden, J., Fligiel, S. and Hogg, J.C.: Bronchopulmonary dysplasia in the adult. Am. Rev. Respir. Dis. 127: 117-120, 1983. 73. Elwood, R.K., Kennedy, S., Belzberg, A., Hogg, J.C. and Pare, P.D.: Respiratory mucosal permeability in asthma. Am. Rev. Respir. Dis. 128: 523-527, 1983. 74. Wright, J.L., Lawson, L.M., Pare, P.D., Hooper, R.O., Peretz, D., Nelems, J.M., Schulzer, M. and Hogg, J.C.: Structure and function of pulmonary vasculature in mild chronic obstructive pulmonary disease: Effect of oxygen and exercise. Am. Rev. Respir. Dis. 128: 702-707, 1983. 75. Kennedy, S.M., Elwood, R.K., Wiggs, B.J.R., Pare, P.D. and Hogg, J.C.: Increased airway mucosal permeability of smokers: Relationship to airway reactivity. Am. Rev. Respir. Dis. 129: 143-148, 1984. 76. Thommasen, H.V., Martin, B.A., Wiggs, B., Quiroga, M., Baile, E. and Hogg, J.C.: Effect of pulmonary blood flow on leukocyte uptake and release by dog lung. J. Appl. Physiol. 56: 966-974, 1984. 1 77. Walker, D.C., MacKenzie, A., Wiggs, B., Hulbert, W.C. and Hogg, J.C.: The structure of tight junctions in the tracheal epithelium may not correlate with permeability. Cell Tissue Res. 235: 607-613, 1984. 78. Muir, A.L., Cruz, M., Martin, B.A., Thommasen, H., Belzberg, A. and Hogg, J.C.: Leukoctye kinetics in the human lung: Role of exercise and catecholamines. J. Appl. Physiol. 57: 711-719, 1984. 79. Thommasen, H.V., Russell, J.A., Boyko, W.J., and Hogg, J.C.: Transient leukopenia in association with the adult respiratory distress syndrome. Lancet 8381: 809-812, 1984. 80. Man, S.F.P., Hulbert, W., Park, D.S.K., Thomson, A.B.R. and Hogg, J.C.: Asymmetry of canine tracheal epithelium: Osmotically-induced changes. J. Appl. Physiol., 57: 1338-1346, 1984.

81. Andr•ew,* D.K., Schellenberg, R.R., Hogg, J.C., Hanna, C.J. and Pare, P.D.: Physiological and immunological effects of chronic antigen exposure in immunized guinea pigs. Int. Arch. Allergy Appl. Immunol. 75: 208-213, 1984. 82. Armour, C.L., Lazar, N.M., Schellenberg, R.R., Taylor, S.M., Chan, N., Hogg, J.C. and Pare, P.D.: A comparison of in vivo and in vitro human airway reactivity to histamine. Am. Rev. Respir. Dis. 129: 907-910, 1984. 83. Wright, J.L., Lawson, L.M., Pare, P.D., Kennedy, S.M., Wiggs, B. and Hogg, J.C.: The detection of small airways disease. Am. Rev. Respir. Dis. 129: 989-994, 1984. 84. Wright, J.L., Wiggs, B.J. and Hogg, J.C.: Airway disease in upper and lower lobes in lungs of patients with and without emphysema. Thorax 39(4):282-285, 1984. ' 85. Bergin, C., Stein, H.B., Boyko, W., Hogg, J.C. and Schlappner, 0. Lymphomatoid granulomatosis presenting as polyarthritis. J. Rheumatology 11: 537-539, 1984. 86. Quiroga, M., Miyagishima, R., Haendschen, L.C., Glovsky, M., Martin, B.A. and Hogg, J.C.: The effect of body temperature on leukocyte kinetics during cardiopulmonary bypass. J. Thoracic Cardiovascular Surg., 90: 91-96, 1985. 87. Hulbert, W.C., McLean, T., Wiggs, B., Pare, P.D., and Hogg, J.C.: Histamine dose-response curves in guinea pigs. J. Appl. Physiol. 58: 625-634, 1985. 88. Wright, J.L., Cosio, M., Wiggs, B. and Hogg, J.C.: A morphological grading scheme for membranous and respiratory bronchioles. Arch. Path. Lab. Med. 109: 163-165, 1985. 89. Walker, D.C., MacKenzie, A., Hulbert, W..C. and Hogg, J.C.: L A re-assessment of the tri-cellular region of epithelial cell tight junctions. Acta Anatomica 122: 35-38, 1985. 90. Baile, E.M., Ling, H., Heyworth, J.R., Hogg, J.C. and Pare, P.D.: Bronchopulmonary anastomotic and non-coronary collateral blood flow in humans during cardiopulmonary bypass. Chest 87: 749-754, 1985. 91. Hulbert, W.C., McLean, T., Walker, D.C. and Hogg, J.C.: The effect of acute airway inflammation on bronchial reactivity in guinea pigs. Am. Rev. Respir. Dis. 132: 7-11, 1985. 92. Taylor, S.M., Pare, P.D., Armour, C.L., Hogg, J.C. and Schellenberg, R.R.: Airway reactivity in COPD: Failure of in vivo methacholine responsiveness to correlate with cholinergic, adrenergic and non-adrenergic responses in vitro. Am. Rev. Respir. Dis. 132: 30-35, 1985.

93. Pare, P:D., Brooks, L.A., Coppin, C.A., Wright, J.L., Kennedy, S., Dahlby, R., Mink, S. and Hogg, J.C.: Density-dependence of maximal expiratory flow and its correlation with small airways disease in smokers. Am. Rev. Respir. Dis. 131: 521-527, 1985. 94. Kennedy, S.M., Walker, D.C., Belzberg, A.S., and Hogg, J.C.: Macrophage accumulation of inhaled gallium-67 citrate in normal lungs. J. Nuclear Med. 26: 1195-1201, 1985. 95. Kennedy, S.M., Wright, J.L., Mullen, J.B.M., Pare, P.D. and Hogg, J.C.: Pulmonary function and peripheral airway disease in patients with mineral dust or fume exposure. Am. Rev. Respir. Dis. 132: 1294-1299, 1985. 96. Hogg, J.C., Martin, B.A., Lee, S. and McLean, T.: Regional differences in erythrocyte transit in normal lungs. J. Appl. Physiol. 59: 1266-1271, 1985. 97. Mullen, J.B.M., Wright, J.L., Wiggs, B.R., Pare, P.D. and Hogg, J.C.: Reassessment of inflammation of airways in chronic bronchitis. Brit. Med. Jour. 291: 1235-1239, 1985. 98. McCormack, G.S., Moreno, R.H., Hogg, J.C. and Pare, P.D.: Lung mechanics in papain-treated rabbits. J. Appl. Physiol. 60: 242-246, 1986. 99. Moreno, R.H., McCormack, G.S., Mullen, J.B.M., Hogg, J.C., Bert, J. and Pare, P.D.: Effect of intravenous papain on tracheal pressure-volume curves in rabbits. J. Appl. Physiol. 60: 247-252, 1986. 100. Mullen, J.B.M., Wiggs, B.R., Wright, J.L., Hogg, J.C. and Pare, P.D.: Non-specific airway reactivity in cigarette smokers - relationship to airway pathology and baseline function. Am. Rev. Respir. Dis. 133: 120-125, 1986. 101. Hobson, J.E., Wright, J.L., Wiggs, B.R. and Hogg, J.C.: Comparison of the cell content of lung lavage fluid with the presence of emphysema and peripheral airways inflammation in resected lungs. Respiration 56: 1-8, 1986. 102. Tsang, J.Y., Baile, E.M. and Hogg, J.C.: The relationship between regional pulmonary edema and blood flow. J. Appl. Physiol. 60: 449-457, 1986. 103. Bergin, C., Muller, N., Nichols, D.M., Lillington, G., Mullen, B., Grymaloski, M.R., Osborne, S., Pare, P.D., and Hogg, J.C.: The diagnosis of emphysema: a computed tomographic-pathologic correlation. Am. Rev. Respir. Dis. 133: 541-546, 1986 104. Wright, J.L., Coppin, C., Mullen, B., Pare, P.D., Rutherford, T., Ling, H., Gerein, A., Miyagishima, R. and Hogg, J.C.: Surgical treatment of lung cancer: promise and problems of early diagnosis. Can. J. Surg. 29: 205-208, 1986.

105. Montaner, J.S.G., Tsang, J., Evans, K.G., Mullen, J.B.M., Burns, A.R., Walker, D.C., Wiggs, B. and Hogg, J.C.: Alveolar epithelial damage: a critical difference between high pressure and oleic acid-induced low pressure pulmonary edema. J. Clin. Invest. 77: 1786-1796, 1986. 106. Tsang, J.Y., Montaner, J.S.C. and Hogg, J.C.: Effects of pulmonary edema on regional blood volume and red blood cell transit time: comparison of high pressure and oleic acid induced edema. J. Clin. Invest. 77: 1780-1785, 1986. 107. VanOostdam, J., Walker, D.C., Knudson, K., Dirks, P., Dahlby, R. and Hogg, J.C.: Effect of breathing dry air on the structure and function of the airways. J. Appl. Physiol. 61: 312-317, 1986. 108. Wright, J.L., Wiggs, B., Pare, P.D. and Hogg, J.C.: Ranking the severity of emphysema on whole lung slices. A brief communication. Am. Rev. Respir. Dis. 133: 930-931, 1986. 109. Magee, F., Wright, J.L., Chan, N., Currie, W., Karr, G., Hogg, J.C. and Thurlbeck, W.M.: Two unusual pathologic reactions to nitrofuratoin. Case Reports. Histopathology 10: 701-706, 1986. 110. Thommasen, H.V., Boyko, W.J., Montaner, J.S., Russell, J.A., Johnson, D.R. and Hogg, J.C.: Absolute lymphocytosis associated with non-surgical trauma. Am. J. Clin. Path. 86: 480-483, 1986. 111. Moreno, R.H., Hogg, J.C., McLean, T.M. and Pare, P.D.: Isovolumetric and isobaric rabbit tracheal contraction in vitro. J. Appl. Physiol. 62: 82-90, 1986. 112. Foster, N.K., Martyn, J.B., Rangno, R.E., Hogg, J.C. and Pardy, R.L.: Leukocytosis of exercise: role of cardiac output and catecholamines. J. Appl. Physiol. 61: 2218-2223, 1986. 113. Moreno, R.H., Hogg, J.C. and Pare, P.D.: Mechanics of airway narrowing. Am. Rev. Respir. Dis. 133: 1171-1180, 1986. ) 114. Thommasen, H.V. and Hogg, J.C.: Trauma, leukocytes and the lung. A review. Cardiovasc. Rev. Reports 7: 369-394, 1986. 115. Thommasen, H.V., Montaner, J., Lee, S., Williams, D., Martin, B.A., Glovsky, M. and Hogg, J.C.: Transient sequestration of polymorphonuclear leukocytes in the lung is not associated with pulmonary injury in dogs. J. Critical Care 1: 204-214, 1986. 116. Muller, N.L., Guerry-Force, M.L., Staples, C.A., Wright, J.L., Wiggs, B., Coppin, C., Pare, P.D. and Hogg, J.C.: Differential diagnosis of bronchiolitis obliterans with organizing pneumonia and usual interstitial pneumonia; clinical, functional and radiologic findings. Thorac. Radiol. 162: 151-156, 1987.

117. Guerry-Force, M.L., Muller, N.L., Wright, J.L., Wiggs, B., Coppin, C., Pare, P.D. and Hogg, J.C.: A comparison of bronchiolitis obliterans with organizing pneumonia, usual interstitial pneumonia and small airways disease. Am. Rev. Respir. Dis., 135: 705-712, 1987. 118. Wright, J.L., Hobson, J., Wiggs, B.R., Pare, P.D. and Hogg, J.C.: Effect of cigarette smokipg on structure of the small airways. Lung 165: 91-100, 1987. 119. Burns, A., Van Oostdam, J., Walker, D.C. and Hogg, J.C.: The effect of anesthesia on cigarette smoke-induced airway injury in guinea pigs. J. Appl. Physiol. 63: 84-91, 1987. 120. Martin, B.A., Wiggs, B.R., Lee, S. and Hogg, J.C.: Regional differences in neutrophil margination in dog lungs. J. Appl. Physiol. 63: 1253-1261, 1987.. 121. Mullen, J.B.M., Wright, J.L., Wiggs, B.R., Pare, P.D. and Hogg, J.C.: Structure of central airways in current smokers and ex-smokers with and without mucus hypersecretion: Relationship to lung function. Thorax 42: 843-848, 1987. 122. Doerschuk, C.M., Allard, M.F., Martin, B.A., MacKenzie, A., Autor, A.P. and Hogg, J.C.: Marginated pool of neutrophils in rabbit lungs. J. Appl. Physiol. 63: 1806-1815, 1987. 123. James, A.L., Pare, P.D., Moreno, R.H. and Hogg, J.C.: Quantitative measurement of smooth muscle shortening in the isolated pig trachea. J. Appl. Physiol. 63: 1360-1365, 1987. 124. Pare, P.D., Armour, C., Taylor, S., Mullen, B., Moreno, R., Hogg, J.C., Schellenberg, R.R.: Airway hyperreactivity in COPD: Cause or effect, an in vivo in vitro comparison. Chest. 91:40S-44S, 1987. 125. James, A.L., Dirks, P., Ohtaka, H., Schellenberg, R.R. and Hogg, J.C.: Airway responsiveness to intravenous and inhaled acetylcholine }in the guinea pig after cigarette smoke exposure. Am. Rev. Resp. Dis. 136: 1158-1162, 1987. 126. Ohtaka, H., Tsang, J.Y., Foster, A., Hogg, J.C. and Schellenberg, R.R.: Effects of leukotrienes and histamine on porcine pulmonary circulation. J. Appl. Physiol. 63: 582-588, 1987. 127. Wright, J.L., Hobson, J., Wiggs, B.R. and Hogg, J.C. Comparison of inflammatory cells in bronchoalveolar fluid with those in the lumen and tissue peripheral airways and alveolar airspace. Lung 166: 75-83, 1988. 128. Walker, D.C., MacKenzie, A.L., Wiggs, B.R., Montaner, J.G. and Hogg, J.C.: Assessment of tight junctions between pulmonary epithelial and endothelial cells. J. Appl. Physiol. 64:2348-2356, 1988.

129. Ohtaka, H., Hogg, J.C., Moreno, R.H., Pare, P.D. and Schellenberg, R.R.: Mechanical properties of porcine intralobar pulmonary arteries. J. Appl. Physiol. 64: 1537-1545, 1988. 130. Allard, M.F., Doerschuk, C.M., Brumwell, M.L., Belzberg, A.S. and Hogg, J.C.: Oleic acid-induced lung injury in rabbits: Effect of fibrinogen depletioit with Arvin. J. Appl. Physiol. 64: 920-928, 1988. 131. James, A., Pare, P.D. and Hogg, J.C.: Effects of lung volume, broncho- constriction and cigarette smoke on morphometric airways dimensions. J. Appl. Physiol. 64: 913-919, 1988. 132. Doerschuk, C.M., Allard, M., Lee, S., Brumwell, M.L. and Hogg, J.C. Effect of epinephrine on neutrophil kinetics in rabbit lungs. J. Appl. Physiol. 65: 401-407, 1988. 133. Osborne, S., Hogg, J.C., Wright, J.L., Coppin, C. and Pare, P.D. Exponential analysis of the pressure-volume curve: correlation with mean linear intercept and emphysema in human lungs. Am. Rev. Respir. Dis. 137: 1083-1088, 1988. 134. James, A.L., Hogg, J.C., Dunn, L.A. and Pare, P.D.: The use of the internal perimeter to compare airway size and to calculate smooth muscle shortening. Am. Rev. Respir. Dis. 138: 136-139, 1988. 135. Hogg, J.C., McLean, T., Martin, B.A. and Wiggs, B. Erythrocyte transit and neutrophil concentration in the lung. J. Appl. Physiol. 65: 1217-1225, 1988. 136. Dodek, P.M., Thommasen, H.V., Russell, J.A., Boyko, W.J. and Hogg, J.C. Neutrophil margination in the lung in adult respiratory distress syndrome. J. Crit. Care 3: 172-179, 1988. 137. James, A.L., Pare, P.D. and Hogg, J.C. The mechanics of airway narrowing in asthma. Am. Rev. Respir. Dis. 139: 242-246, 1989. ~ 138. Hulbert, W.C., Forster, B.B., Mehta, J.G., Man, S.F.P., Molday, R.S., Walker, B.A., Walker, D.C. and Hogg, J.C. A study of airway epithelial permeability with dextran. J. Electron Microscopy Technique 11: 137-142, 1989. 139. MacNee, W., Martin, B.A., Wiggs, B., Belzberg, A.S. and Hogg, J.C. Regional pulmonary transit times in humans. J. Appl. Physiol. 66: 844-850, 1989. 140. Ohgami, M., Doerschuk, C.M., English, D., Dodek, P.M. and Hogg, J.C. Kinetics of radio-labelled neutrophils in swine. J. Appl. Physiol. 66: 1881-1885, 1989. 141. Hogg, J.C., Irving, W.L., Porter, H., Evans, M., Dunnill, M.S. and Fleming, K. In situ hybridization studies of adenoviral infections of the lung and their relationship to follicular bronchiectasis. Am. Rev. Respir. Dis. 139: 1531-1535, 1989.

142. Burns, A.L., Hosford, S.P., Dunn, L.A., Walker, D.C. and Hogg, J.C. Respiratory epithelial permeability after cigarette smoke exposure in guinea pigs. J. Appl. Physiol. 66: 2109-2116, 1989. 143. MacNee, W., Martin, B.A., Wiggs, B., Belzberg, A.S. and Hogg, J.C. The effect of cigarette smoking on neutrophil kinetics in human lungs. N. Engl. J. Med. 321: 924-928, 1989. 144. Doerschuk, C.M., Allard, M.F. and Hogg, J.C. Neutrophil kinetics in rabbits during infusion of zymosan-activated plasma: role of decreased PMN deformability in microvascular sequestration. J. Appl. Physiol. 67: 88-96, 1989. 145. Doerschuk, C.M., Downey, G.P., Doherty, D.E., English, D., Gie, R.P., Ohgami, M., Worthen, G.S., Henson, P.M. and Hogg, J.C. Leukocyte and platelet margination within the microvasculature of rabbit lung. Submitted to J. Appl. Physiol.,•1989. 146. Burns, A.R., James, A.L., Greene, S., Schellenberg, R.R. and Hogg, J.C. The effect of airway sensory C fibre network degeneration on the increased airway permeability and responsiveness produced by cigarette smoke. Submitted to Pulm. Pharmacol., 1989. 147. Markos, J., Hooper, R.O., Kavanagh-Gray, D., Wiggs, B.R. and Hogg, J.C. The effect of raised alveolar pressure on leukocyte retention in the lung. Accepted, J. Appl. Physiol., 1990. 148. Matsuba, K., Wright, J.L., Wiggs, B.R., Pare, P.D. and Hogg, J.C. The changes in airways structure associated with reduced forced expiratory volume in one second. Eur. Respir. J., in press, 1989. 149. Wiggs, B.R., Moreno, R., Hogg, J.C., Hilliam, C. and Pare, P.D. A model of the mechanics of airway narrowing. J. Appl. Physiol., in press, 1990. 150. Bosken, C.H., Wiggs, B., Pare, P.D. and Hogg, J.C. Small air ay dimensions in smokers with obstruction to airflow. Am. Rev. Relpir. Dis., in press, 1990. 151. Brumwell, M.L., MacNee, W., Doerschuk, C.M.,. Wiggs, B. and Hogg, J.C. Neutrophil kinetics in normal and emphysematous regions of human lung. Submitted to Ann. NY Acad. Sci., June, 1990. 152. Gie, R.P., Doerschuk, C.M., English, D., Coxson, H.O. and Hogg, J.C. Neutrophil-associated lung injury following the infusion of activated plasma. Submitted to J. Appl. Physiol., June, 1990.

CHAPTERS IN BOOKS 1. Hogg, J.C.: The Respiratory Airways. in: Pulmonary Medicine. Guenter and Welch, Editors. J.B. Lippincott Company, Philadelphia, 1976. 2. Revised July, 1980. Hogg, J.C.: The Effect of Pulmonary Edema on the Distribution of Blood Flow in the Lung. In: Lung Biology in Health and Disease. Claude Lenfant, Editor. Marcel Dekker, Inc., New York, 1977. 3. Hogg, J.C., Pare, P.D., Boucher, R.C., Michoud, M.-C., Guerzon, G., and Moroz, L.A.: Pathologic Abnormalities in Asthma. In: Asthma II - Physiology, Immunopharmacol ogy and Treatment. L.M. Lichtenstein et al., Editors. Academic Press, N ew York, 1977. pp. 1-19. 4. Hogg, J.C.: Age as a Factor in Respiratory Tract Disease. In: Disorders of the Respiratory Tract in Children. E.L. Kendig and V. Chernick, Editors. W.B. Saunders Co., Philadelphia, 197 7. 5. Rose, B., Hogg , J.C., and Macklem, P.T.: The Pathogenesis of Asthma. In: Immunological Diseases, 3rd Edition. M. Samptor, D. Talmage, B. Rose, F. Austen and J. Vaughn, Editors. Little, Brown and Co., 1977. 6. Hogg, J.C.: Bronchial Asthma. In: The Lung: International Academy of Pathology Monograph No. 19. W.M. Thurlbeck and M.R. Abell, Editors. The Williams and Wilkins Co., Baltimore, Md., 1978. pp. 180-191. 7. Pare, P.D., and Hogg, J.C.: The Pathophysiology of Allergic Airways Disease. In: Clinical Advantages of Topical Treatment. Mygind and Clark, Editors. Bailliere Tindall, London, England, 1979. pp. 12-21. 8. Hogg, J.C.: Pathology of Asthma. In: Allergy: Principles and Practice, 2nd Edition. E. Middleton, C.E. Reed, E.F. Ellis, Editors. C.V. Mosby Company, St. Louis, Miss., 1 982. 9. Hogg, J.C.: Pathology of A sthma. In: Clinics in Chest Medicine. W.C. Bailey, Editor. W.B. Saunders Company, Philadelphia, Pa., 1984. pp. 567-71. 10. Hogg, J.C.: Pathology of Asthma. In: Bronchial Asthma: Mechanisms and Therapeutics. E.B. Weiss, M.S . Segal and M. Stein, Editors. Little, Brown Company, Boston, Ma., 198 4. 11. Hogg, J.C.: Peripheral Airways Inflammation. In: International Review of Experimental Pathology. Volume 28. G.W. Richter, Editor. Academic Press, Inc., New York. 1986. pp. 117-161. 12. Hogg, J.C.: The Assessment of Pulmonary Microvascular Permeability and Edema. In: The Pulmonary Circulation and Acute Lung Injury. S. Said, Editor. Futura Publishing Co., Inc., Mount Kisko, NY. 1985. Chap. 9, pp. 209-224.

- 20 - 13. Hogg, J.C.: Neutrophil Kinetics and Lung Injury. In: Physiological Reviews. P.A. Bromberg, Editor. Am. Physiol. Soc., publishers. Bethesda. Physiol. Rev. 67: 1249-1295, 1987. 14. Hogg, J.C.: The Interaction Between Polymorphonuclear Cells and Pulmonary Endothelium: Normal Kinetics and the Pathogenesis of Acute Lung Injury. In: Pulmonary Vascular Physiology and Pathophysiology. E. Kenneth Weir and John T. Reeves, Editors. Monograph Series: Lung Biology in Health and Disease. C. Lenfant, Editor. Marcel Dekker, Inc., New York, Basel. 1989. Chapter 17, pp. 613-641. 15. Hogg, J.C. Normal and Abnormal Airway Cell Structure. In: Asthma: Basic Mechanisms and Clinical Management. P. Barnes, Editor. Academic Press Inc., London. 1988. Chapter 1, pp. 1-10. 16. Hogg, J.C. Airways Hyperreactivity: Relationship to Uisease States. In: Airway Smooth Muscle in Health and Disease. Publ. Corp., New York, London, Washington, B R.F. Coburn, Editor. Plenum oston. 1989. Chapter 13, pp. 267-276. 17. Hogg, J.C. Extrinsic Allergic Alveolitis and Occupational Asthma. In: Pathology of Occupational Lung Disease. Andrew Churg and Francis H.Y. Green, Editors. Igaku-Shoim Medical Publishers, Inc., New York, 1988. Chap. 10. pp. 331-349. 18. Hogg, J.C. Pulmonary Defence Mechanisms. In: Pathology of the Lung. W.M. Thurlbeck, Editor. Thieme Medical Publishers, Inc., New York. 1988. Chap. 4, pp. 57-66. 19. Hogg, J.C. and Katzenstein, A.L. Pulmonary Edema and Diffuse Alveolar Injury. In: Pathology of the Lung. W.M. Thurlbeck, Editor. Thieme Medical Publishers, Inc., New York. 1988. Chap. 16, pp. 263-282. 20. Hogg, J.C. Extrinsic Immunologic Lung Disease. In: Pathology of the Lung. York. W.M. 1988. Thurlbeck, Editor. Thieme Medical Publishers, Inc.f New Chap. 22, pp. 577-589. 21. Hogg, J.C. Airway Structure and Function. In: Respiratory Function in Disease, Third Edition. D.V. Bates, Editor. W. London, Toronto, Montreal, Sydney, Tokyo. 1989. B. Saunders Company, Chapter 1, pp. 1-22. 22. Reid, L.M., Gleich, G.J., Hogg, J.C., Kleinerman, J. and Laitinen, L.A. Pathology. In: The Role of Inflammatory Processes in Airway Hyperresponsiveness. S.T. Holgate, Editor-in-Chief. Blackwell Scientific Publications, Oxford, London, Edinburgh, Boston, Melbourne. 1989. Chap. 2, pp. 36-79. 23. Hogg, J.C. Mucosal Permeability and Smooth Muscle Function in Asthma. In: Medical Clinics of North America: Obstructive Lung Disease. James A. Dosman and Donald W. Cockcroft, Editors. W.B. Saunders Company, Philadelphia, London, Toronto, Montreal, Sydney, Tokyo. 1990. Vol. 74. pp. 731-740.

EDITORIALS 1. Hogg, J.C.: Pathophysiology of Asthma. C.M.A.J. 110: 375-376. 1974. 2. Hogg, J.C.: The histologic appearance of Farmer's Lung. Editorial, Chest 81: 133-134, 1982. 3. Hogg, J.C.: Vascular obstruction in post-traumatic shock lung. Am. J. Roentgenol. 139: 623-624, 1982. 4. Hogg, J.C.: The effect of smoking on airways permeability. Editorial, Chest 83: 1-2, 1983. 5. Hogg, J.C. and Eggleston, P.A.: Is asthma an epithelial disease? Am. Rev. Respir. Dis., 129: 207-208, 1984. PROCEEDINGS (Contributions to symposia and other non-refereed publications) 1. Macklem, P.T., Hogg, J.C., and Thurlbeck, W.M.: Flow resistance of central and peripheral airways in human lung. In Form and Function in the Human Lung. Eds. Gordon Cumming and L.B. Hunt. E. & S. Livingston, Edinburgh, 1968. pp. 76-88. 2. Hogg, J.C., Macklem, P.T., and Thurlbeck, W.M.: The resistance of small airways in normal and diseased human lung. In Current Research in Chronic Obstructive Lung Disease. Proceedings of the Tenth Aspen Emphysema Con- ference, 1967, published by the U.S. Department of Health, Education and Welfare (Publ. Hlth. Serv. Publ. No. 1787, 1969, pp. 433-441). 3. Woolcock, A.M., Macklem, P.T., Hogg, J.C., Wilson, N.J., Nadel, J.A., Frank, N.R., and Brain, J.: The response of central and perip eral airways to vagal stimulation in dogs. In Current Research in Chronic Obstructive Lung Disease. Proceedings of the Tenth Aspen Emphysema Conference, 1967, published by the U.S. Department of Health, Education and Welfare (Publ. Hlth. Serv. Publ. No. 1787, 1969, pp. 275-285). 4. Hogg, J.C.: The effect of lung growth on the distribution of airways resistance. Ciba Symposium on the Identification of Asthma. 1971. pp. 47-62. 5. Weinstein, R.S., Hogg, J.C., Nash, G., and McNutt, N.S.: Freeze-cleaved lung. A preliminary report on the ultrastructure of the alveolar sac in normal mouse. Proceedings of the lst Annual Conference on Environmental Toxicology. September, 1960, pp. 251-273. 6. Hogg, J.C.: Sites and mechanisms of airways obstruction in chronic obstructive pulmonary disease. Post-graduate Medicine 54: 89-95, 1973.

- 22 - 7. Hogg, J.C., Pare, P.D., Boucher, R.C., and Michoud, M.-C.: The patho- physiology of asthma. Presented at the Canadian Medical Association Meeting, June 23, 1978. C.M.A.J. 121: 409-414, 1979. 8. Hogg, J.C., Pare, P.D., Boucher, R.C., and Michoud, M.-C.: The patho- physiology of airways obstruction in a primate model of asthma. Presented at the Internationi(l Symposium on Mechanisms of Airways Obstruction, Cape Town, South Africa, April, 1978, pp. 91-104. 9. Hogg, J.C., Pare, P.D., and Boucher, R.C.: Structure and function of airways in Ascaris-sensitive monkeys. Presented at the 12th Symposium of the Collegium Internationale Allergologicum, New Orleans, Louisianna, September 1978. Monographs in Allergy 14: 106-115, 1979 (Karger, Basel). 10. Hogg, J.C., Pare, P.D., and Boucher, R.C.: Bronchial mucosal perme- ability. Pulmonary Structure Symposium, Federation of'American Societies for Experimental Biology, Atlantic City, April, 1978. Federation Proceedings. 11. Hogg, J.C., and Cosio, M.: The pathophysiology of small airways. Proceedings of a Symposium on "Small Airways in Health and Disease", Copenhagen, March 1979 (sponsored by Astra Company). Excerpta Medica, 1980, pp. 33-39. 12. Hogg, J.C.: Airways dimensions - changes in disease. Chest 80S: 789S-791S, 1981 Suppl. 13. Hogg, J.C.: Bronchial mucosal permeability and its relationship to airways hyperreactivity. J. Allerg. Clin. Immunol. 67: 421-425, 1981. 14. Hogg, J.C.: The pathophysiology of asthma. Chest 82 Suppl.: 8S-12S, 1982. 15. Hogg, J.C.: Bronchial mucosal permeability and its relationship to airways hyperreactivity. Europ. J. Resp. Dis., Supplement, 198pp. 17-22. 16. Hogg, J.C.: Structural changes in the adult respiratory distress syndrome. Proceedings of First Boehringer-Ingelheim Chest Symposium, Asia Pacific Congress, Series No. 27. Excerpta Medica, 1983, pp. 2-8. 17. Hogg, J.C.: Hyaline membrane disease of the newborn. Proceedings of First Boehringer-Ingelheim Chest Symposium, Asia Pacific Congress, Series No. 27. Excerpta Medica, 1983, pp. 124-131. 18. Hogg, J.C.: The pathology of asthma. Proceedings of 3rd Congress of European Society of Pneumology, Basel, 1984. Excerpta Medica 3-10, 1985. 19. Hogg, J.C.: Chronic obstructive lung disease: Research. B.C.M.J. 26: 665-667, 1984.

- 23 - 20. Hogg, J.C., Hulbert, W.C., Armour, C. and Pare, P.D.: The effect of mucosal inflamntation on airways reactivity. In Asthma: Physiology, Immunopharmacology and Treatment. Third International Symposium. Eds. A. Barry Kay, K. Frank Austen, Lawrence Id. Lichtenstein. Academic Press, Inc., London, New York, Toronto. 1985. Chap. 20, pp. 327-338. 21. Hogg, J.C.: The pathology of asthma. Proceedings of Aspen Lung Conference, 1984. Chest 875: 152-153S, 1985. 22. Hogg, J.C., and Walker, D.C.: Pathology of the airway epithelium in asthma. Proceedings of International Workshop on the Cellular Basis of Bronchial Hyperresponsiveness, Lunteren, The Netherlands, January 1985. Sponsored by The Netherlands Asthma Foundation and Fisons Netherlands. Bull. Europ. Physiopath. Resp. 1985. 23. Hogg, J.C., Wright, J.L. and Pare, P.D.: Airways di-sease: evolution, pathology and recognition. Symposium on Occupational Lung Disease, Thoracic Society of Australia, Perth, May, 1983. ried. J. Aust. 142: 605-607, 1985. 24. Hogg, J.C.: Response of the lung to inhaled particles. Symposium on Occupational Lung Disease, Thoracic Society of Australia, Perth, May, 1983. Med. J. Aust. 142: 675-678, 1985. 25. Hogg, J.C.: The inflammatory process in peripheral airways. Presented to Japanese Thoracic Society, April 1985. J. Jap. Thoracic Soc. 23: 981-990, 1985. 26. Hogg, J.C.: Airway structure and function in asthma. Aspen Allergy Conference III: Mechanisms in Allergy. Allergy Proceedings 7: 228-235, 1986. 27. Hogg, J.C.: Structural features and functional consequences of the inflammatory events in asthma. Symposium on Platelet Activating Factor, Pulmonary Hyperreactivity Montreal, 1986. and Asthma. Sponsored by Sandoz Car~ada, 28. Hogg, J.C.: Primary pulmonary hypertension. Pulmonary Circulation and Pulmonary Hypertension. Guest Editor, Norbert F. Voekel. 30th Annual Aspen Lung Conference. June 1987. Chest 93: 172S-175S, 1988. 29. Hogg, J.C.: Varieties of airway narrowing in severe and fatal asthma. Proceedings of Asthma Mortality Task Force, Bethesda, 1986. Workshop on Pathology. L. Reid, Editor. J. Allergy Clin. Immunol. 80 (No. 3, part 2 Supplement): 417-419, 1987. 30. Hogg, J.C., Pare, P.D. and Moreno, R.: The effect of submucosal edema in airways resistance. Am. Rev. Respir. Dis. 135 (Supplement): S54-S56, 1987.

- 24 - 31. Hogg, J.C., Pare, P.D. and Wright, J.L. Relationship between airway pathology and airway obstruction. Bronchitis IV. Proceedings of Fourth International Symposium on Bronchitis. Groningen, The Netherlands, May 1988. H.J. Sluiter, R. Van der Lende, Editors. Van Gorcum, Assen, The Netherlands. 1988. pp. 123-134. 32. Hogg, J.C., James.. A.L., and Pare, P.D. New developments in the pathology of bronchial asthma. In: Glucocorticoids and Mechanisms of Asthma. Proceedings of a Symposium in Toronto, November, 1988, sponsored by AB Draco. F.E. Hargreave, J.C. Hogg, J-L. Malo, J.H. Toogood, Editors. Excerpta Medica, Amsterdam, Hong Kon, Manila, Princeton, Sydney, Tokyo. 1989. pp. 262-268. 33. Hogg, J.C. Morphologic features of the lung in the respiratory failure associated with hypovolemic and septic shock. In: Progress in Clinical and Biological Research. Proceedings of Second Vienna Shock Forum. Alan R. Liss, Inc., New York. 1989. Vol. 308, pp. 27-35. 34. Hogg, J.C. Structural features and functional consequences of the inflammatory events in asthma. In: Perspectives in Asthma - 3: PAF in Asthma. C. Holme and J. Morley, eds. Proceedings of Symposium, June 1986. Academic Press, London, Boston, Toronto. 1989. Chap. 9, pp. 131-144. I

- 25 - ABSTRACTS 1. Walker, D.C., MacKenzie, A., Wiggs, B., Montaner, J.S.G., and Hogg, J.C.: Tight junction morphology and permeability. Microvasc. Res. 3: 261, 1983. 2. Hulbert, W.C., Wiggs, B., Pare, P.D., and Hogg, J.C.: The effect of volume history on histamine dose-response curves. Fed. Proc. 42: 1009, #4199, 1983. 3. Cruz, M., Montaner, J.S.G., Martin, B., Glovsky, M., Walker, D.C., and Hogg, J.C.: Pulmonary polymorphonuclear leukocyte sequestration and activation as a model of the adult respiratory distress syndrome CARDS). Fed. Proc. 42: 503, #1237, 1983. 4. Montaner, J.S.G., Walker, D.C., MacKenzie, A., Baile, E.M. and Hogg, J.C.: A comparison of high pressure and normal pressure edema on the redistri- bution of blood flow in the lung. Fed. Proc. 42: 491, #1170, 1983. 5. Glovsky, M.M., Ryan, U., Quiroga, M., Hogg, J.C., Kunkel, S., and Ward, P.A.: Endothelial cell damage: A potential component of anaphylaxis and respiratory distress syndrome (ARDS). Fed. Proc. 42: 916, #3651, 1983. 6. Pare, P.D., Brooks, L.A., Coppin, C.A., Wright, J.L., Kennedy, S., Wiggs, B.J., and Hogg, J.C.: Density dependence of maximal expiratory flow and airway pathology in smokers. Am. Rev. Respir. Dis. 127: 252, 1983. 7. Pare, P.D., Coppin, C.A., Brooks, L., Wright, J.L., Dahlby, R., and Hogg, J.C.: Upstream resistance in COPD patients with emphysema and small airways inflammation. Am. Rev. Respir. Dis. 127: 256, 1983. 8. Fromberg, M., Baile, E.M., Wright, J.L., Pare, P.D., and Hogg, J.C.: Early functional changes seen with minimal airways inflammation is associated with exudation. Am. Rev. Respir. Dis. 127: 244, 1983. ' 9. Kennedy, S., Pare, P.D., Elwood, K., Wiggs, B., and Hogg, J.C.: Lung epithelial permeability and airway reactivity in smokers and non-smokers. Am. Rev. Respir. Dis. 127: 252, 1983. 10. Otto, R., Glovsky, M.M., Brenner, W., Quiroga, M., and Hogg, J.C.: Systemic anaphylaxis associated with cardiopulmonary bypass in man. Annual Meeting, American Academy of Allergy and Immunology, 1983. 11. Armour, C.L., Lazar, N.M., Schellenberg, R.R., Hogg, J.C., and Pare, P.D.: Relationship between airway smooth muscle volume and histamine reactivity in vivo/in vitro in human airways. Royal Australian College of s c a Phii 1983 u' y ns , . I.- Ln _j tD J N (I1 bP

- 26 - 12. Hogg, J:C., Muir, A.L., Cruz, M., Martin, B.A., and Thommasen, H.: Demargination of polymorphonuclear leukocytes (PMN) from the human lung during exercise. J. Clin. Invest. Med. 6: 76, 1983. 13. Thommasen, H., Johnson, D., Boyko, W., Russell, J., and Hogg, J.C.: The peripheral white blood cell (WBC) count following trauma and in the adult respiratory distress syndrome (ARDS). J. Clin. Invest. Med. 6: 78, 1983. 14. Hulbert, W.C., McLean, T., Pare, P.D., and Hogg, J.C.: The relationship between cigarette smoke-induced airway inflammation and histamine reactivity in guinea pigs. J. Clin. Invest. Med. 6: 76, 1983. 15. Baile, E.M., Ling, H., Heyworth, J.R., Evans, K.G., Osborne, T., Hogg, J.C., and Pare, P.D.: Measurement of bronchopulmonary anastomotic blood flow in humans undergoing coronary artery bypass (CAB). J. Clin. Invest. Med. 6: 75, 1983. - 16. Martin, B.A., Lee, S., Quiroga, M., and Hogg, J.C.: Regional differences in polymorphonuclear leukocyte (PMN) transit through the dog lung. Annual Meeting, American Physiological Society, 1983. (Physiologist) 17. Hogg, J.C., Muir, A.L., Cruz, M., Martin, B..A., and Thommasen, H.: Demargination of polymorphonuclear leukocytes (PMN) from the human lung during exercise. XXIX Congress International Union of Physiological Sciences, Sydney, Australia, 1983. 18. Kennedy, S.M., Wright, J.L., Pare, P.D., and Hogg, J.C.: Small airways structure and function in persons exposed to industrial dusts and fumes. Annual Meeting, Canadian Lung Association, 1983. 19. Hobson, J.E., Wright, J.L., Wiggs, B.R., and Hogg, J.C.: The cellular content of lung lavage in patients with COPD. Am. Rev. Respir. Dis. 129: A67, 1984. 20. Kennedy, S.M., Mullen, J.B.M., Wright, J.L., Pitman, R.G., Pare, P.D., and Hogg, J.C.: Small airway structure and function in persons 4xposed to mineral dust or fume. Am. Rev. Respir. Dis. 129: A148, 1984. 21. Mullen, J.B.M., Wiggs, B.R., Wright, J.L., Pare, P.D., and Hogg, J.C.: Cartilaginous airway inflammation in smokers. Am. Rev. Respir. Dis. 129: A317, 1984. 22. Montaner, J.S.G., Wiggs, B.R., Walker, D.C., and Hogg, J.C.: The distribution of extravascular lung water (EVLW) in high (HPPE) and low pressure pulmonary edema (LPPE). Am. Rev. Respir. Dis. 129: A346, 1984. 23. Martin, B.A., Cybulsky, M., Lee, S., and Hogg, J.C.: Comparison of polymorphonuclear (PMN) and mononuclear (MONO) leukocyte transit through the rabbit lung. Federation of Societies for Experimental Biology Annual Meeting, 1984.

i - 27 - 24. Hogg, J.C., Martin, B.A., Lee, S., and Wiggs, B.R.: Regional differences in the time of red cell transit through dog lungs. Federation of Societies for Experimental Biology Annual Meeting, 1984. 25. Tsang, J.Y., Baile, E.M., and Hogg, J.C.: The increase in shunt fraction (Qs/Qt) associated with increased cardiac output in low pressure pulmonary edema is' not explained by increased flow to edematous lung regions. Federation of Societies for Experimental Biology Annual Meeting, 1984. 26. Mullen, J.B.M., Wiggs, B.R., Wright, J.L., Pare, P.D., and Hogg, J.C.: The morphologic features of chronic bronchitis: A reassessment. Canadian Society for Clinical Investigation Annual Meeting, 1984. 27. Mullen, J.B.M., Wright, J.L., Wiggs, B.R., Pare, P.D., and Hogg, J.C.: The relationship of bronchial reactivity to airway morphology and airflow obstruction in smokers. Canadian Society for Clinical Investigation Annual Meeting, 1984. 28. Moreno, R., Hogg, J.C., and Pare, P.D.: Isovolume and isopressure tracheal contraction in vivo. Canadian Society for Clinical Investigation Annual Meeting, 1984. 29. Lee, S., Martin, B.A., and Hogg, J.C.: The effect of acute cigarette smoke exposure on regional pulmonary blood volume and flow in the rabbit lung. Canadian Society for Clinical Investigation Annual Meeting, 1984. 30. Kennedy, S.M., Mullen, J.B.M., Wiggs, B.R., Pare, P.D., and Hogg, J.C.: Increased respiratory epithelial permeability immediately following acute smoking. Canadian Society for Clinical Investigation Annual Meeting, 1984. 31. Baile, E.M., Dahlby, R.W., and Pare, P.D.: Effect of hyperventilation with warm-dry and cold-dry air on central airway blood flow. Canadian Society for Clinical Investigation Annual Meeting, 1984. } 32. Montaner, J.S.G., Mullen, J.B.M., MacKenzie, A., Walker, D.C., and Hogg, J.C.: Extravascular lung water in pulmonary edema: A morphometric analysis. XXII Congreso Brasileno de Neumologia Y Tisiologia, 1984. 33. Mullen, J.B.M., Montaner, J.S.G., Wright, J.L., Wiggs, B.R., Pare, P.D., and Hogg, J.C.: Non-specific airway reactivity in cigarette smokers - relationship to airway pathology and baseline lung function. XXII Congreso Brasileno de Neumologia Y Tisiologia, 1984. 34. Martin, B.A., Doerschuk, C., and Hogg, J.C.: Distribution of labelled mononuclear (mono) and polymorphonuclear (PMN) leukocytes in the rabbit. Fed. Proc. 44: 1754, #7852, 1985.

- 28 - 35. Hogg, J'.C., Martin, B.A., and Lee, S.: The relationship of red blood cell (RBC) transit time to polymorphonuclear leukocyte (PMN) turnover in the pulmonary circulation. Fed. Proc. 44: 1757, #7868, 1985. 36. Walker, D.C., Knudson, K., Van Oostdam, J., and Hogg, J.C.: Alterations in extravascular water of guinea pig tracheas produced by breathing dry air. Fed. Proc. 44~ 642, #1357, 1985. 37. Van Oostdam, J., Walker, D.C., and Hogg, J.C.: Effect of dry air on guinea pig airway reactivity. Fed. Proc. 44: 837, #2489, 1985. 38. Tsang, J.Y., Montaner, J.S.G., and Hogg, J.C.: Regional transit time of red blood cells in dog lungs with pulmonary edema. Fed. Proc. 44: 1754, #7850, 1985. 39. Bainbridge, T.C., Walker, D.C., and Hogg, J:C.: A model of bronchogenic carcinoma in the golden Syrian hamster. Fed. Proc. 44: 927, #3019, 1985. 40. Ohtaka, H., Tsang, J.Y., Foster, A., Hogg, J.C., and Schellenberg, R.R.: The effect of leukotrienes on porcine pulmonary circulation. Fed. Proc. 44: 1758, #7875, 1985. 41. Moreno, R.H., Hogg, J.C., McLean, T., and Pare, P.D.: In situ smooth muscle shortening in excised rabbit tracheas. Fed. Proc. 44: 837, #2490, 1985. 42. Moreno, R., Dahlby, R., Hogg, J.C., and Pare, P.D.: Increased airway responsiveness caused by airway cartilage softening in rabbits. Am. Rev. Respir. Dis. 131: A288, 1985. 43. Wright, J.L., Hobson, J., Wiggs, B.R., and Hogg, J.C.: The relationship of airway inflammation to intrapulmonary lavage. Submitted to American Thoracic Society Annual Meeting, 1985. 44. Doerschuk, C., Martin, B.A., Walker, D.C., Kennedy, S., and Hogg~p J.C.: Localization of 111In labelled polymorphonuclear leukocytes witttin the circulation: an autoradiographic study. Submitted to the Canadian Society for Clinical Investigation, 1985. 45. Wiggs, B.R., Martin, B.A., Doerschuk, C., McLean, T., and Hogg, J.C.: The transit time of red blood cells through the lung: an in vivo in vitro comparison in dogs. Submitted to Canadian Thoracic Society, 1985. 46. Foster, N.K., Martyn, J.B., Fairbarn, M.S., Hogg, J.C., and Pardy, R.L.: The leukocytosis of exercise: role of cardiac output and catecholamines. Submitted 1985. 47. Guillemi, S., Coppin, C., Osborne, S., Hogg, J.C., Wiggs, B.J.R., Wright, J.L., and Pare, P.D.: Pre-operative predictors of post-operative mortality following resectional surgery for carcinoma of the lung. Am. Rev. Respir. Dis. 131: A355, 1985.

- 29 - 48. Moreno, R., Hogg, J.C., Wiggs, B.J.R., and Pare, P.D.: Mechanical factors in airway hyperresponsiveness (HR). Submitted 1985. 49. Bainbridge, T.C., Walker, D.C., and Hogg, J.C.: A practical model of bronchogenic carcinoma in the Cam Hartley guinea pig and the Golden Syrian hamster. Submitted to the Canadian Society for Clinical Investigation, 1985: 50. Mullen, J.B.M., Wright, J.L., Wiggs, B.R., Hogg, J.C. and Pare, P.D.: Non-specific airway reactivity, baseline lung function and airway pathology in cigarette.smokers. Am. Rev. Respir. Dis. 131: A342, 1985. 51. Ohtaka, H., Foster, A., Cory, R., Hogg, J.C. and Schellenberg, R.R.: Effect of leukotriene C4 (LTC4) and histamine on regional blood flow (RBF) in pig lung. Physiologist 28: 347, Abst. #63.6, 1985. 52. Burns, A.R., Van Oostdam, J., Walker, D.C. and Hogg, J.C.: Effect of anesthesia on increased respiratory epithelial permeability induced by cigarette smoke in guinea pigs. Submitted to Federation of American Societies for Experimental Biology, 1986. 53. Tsang, J.Y., Leasa, D., Hogg, J.C. and Robertson, H.T.: Venous admixtures and lung water in two different models of lung edema. Submitted to Federation of American Societies for Experimental Biology, 1986. 54. Ohtaka, H., Cory, R., Hogg, J.C. and Schellenberg, R.R.: Effect of microspheres on pulmonary circulation with leukotriene C4 (LTC4) and histamine (HIS). Submitted to Federation of American Societies for Experimental Biology, 1986. 55. Matsuba, K., Wright, J.L., Wiggs, B., Pare, P.D. and Hogg, J.C.: The change in airways structure associated with reduced forced expiratory volume in one second (FEV1). Am. Rev. Respir. Dis. 133: A30, 1986. 56. James A.L., Pare, P.D., Moreno, R. and Hogg, J.C.: Smooth mu6cle shortening and airway narrowing in porcine tracheal rings. Am. Rev. Respir. Dis. 133: A113, 1986. 57. Guerry-Force, M., Muller, N., Wright, J., Wiggs, B., Coppin, C., Pare, P.D. and Hogg, J.C.: A comparison of usual interstitial pneumonia (UIP), bronchiolitis obliterans with organizing pneumonia (BOOP) and small airways disease (SAD). Am. Rev. Respir. Dis. 133: A24, 1986. 58. Doerschuk, C.M., Martin, B.A., MacKenzie, A., Walker, D.C. and Hogg, J.C.: Localization of the pulmonary marginated pool of neutrophils and comparison of the distribution of labeled and unlabeled neutrophils in the rabbit's pulmonary vasculature. Am. Rev. Respir. Dis. 133: A272, 1986.

- 30 - 59. MacNee, 'W., Martin, B.A., Wiggs, B., Belzberg, A. and Hogg, J.C.: Regional pulmonary red cell transit times in man - the effects of smoking. Am. Rev. Respir. Dis. 133: A65, 1986. 60. Foster, N.K., Martyn, J.B., Fairbarn, M.S., Hogg, J.C., Rangno, R. and Pardy, R.L.: Exercise leukocytosis: role of cardiac output and catecholamines. Am: Rev. Respir. Dis. 133: A381, 1986. 61. Osborne, S., Hogg, J.C., Wright, J.L., Coppin, C. and Pare, P.D.: Exponential analysis of the pressure volume (PV) curve: correlation with mean linear intercept (Lm) and emphysema in human lungs. Submitted to American Thoracic Society Meeting, May 1986. 62. Guillemi, S., Coppin, C., Osborne, S., Wright, J.L., Hogg, J.C. and Pare, P.D.: Density dependence of maximum expiratory flow and pulmonary resistance - correlation with small airway pathology-in smokers. Am. Rev. Respir. Dis. 133: A31, 1986. 63. Hogg, J.C., Martin, B.A. and McLean, T.: The time spent by erythrocytes (RBC) in different segments of the pulmonary vasculature. Submitted to International Union of Physiological Sciences, July 1986. 64. Ohtaka, H., Moreno, R., Hogg, J.C. and Schellenberg, R.R.: Porcine pulmonary artery (PA) pressure/volume (P/V) characteristics in vitro. Submitted to International Union of Physiological Sciences, July 1986. 65. Moreno, R., Lisboa, C., Hogg, J.C. and Pare, P.D.: Limitation of airway smooth muscle shortening by lung elastic recoil and cartilage stiffness in rabbits. Submitted to International Union of Physiological Sciences, July 1986. 66. Moreno, R., Hogg, J.C. and Pare, P.D.: Contribution of the elastic properties of cartilaginous rings to tracheal smooth muscle (TSM) preload. Submitted to International Union of Physiological Sciences, July 1986. f 67. Doerschuk, C., Allard, M.F., Martin, B.A., MacKenzie, A., Walker, D.C. and Hogg, J.C.: The localization and turnover of the marginated pool of neutrophils in the rabbit's lung. Clin. Invest. Med. 9: A153 (Abst. #R953), 1986. 68. James, A.L., McLean, T., Pare, P.D. and Hogg, J.C.: Airway wall thickness and bronchial hyperreactivity in the guinea pig. Clin. Invest. Med. 9: A153 (Abst. #R957), 1986. 69. Allard, M.F., Doerschuk, C.M., Belzberg, A. and Hogg, J.C.: The evolution of the acute oleic acid-induced lung injury in rabbits. Clin. Invest. Med. 9: A155 (Abst. #A967), 1986.

70. MacNee,-W., Martin, B.A., Wiggs, B., Belzberg, A. and Hogg, J.C.: The effect of smoking on the distribution of pulmonary transit times in man. Clin. Invest. Med. 9: A153 (Abst. #R954), 1986. 71. Russell, J.A., Thommasen, H.V., Boyko, W.J., Montaner, J.S., Johnson, D.R. and Hogg, J.C.: Transient absolute lymphocytosis after trauma. Clin. Invest. Med. 9: A176 (Abst. #1101), 1986. 72. Dodek, P.M., Thommasen, H.V., Russell, J.A., Boyko, W.J. and Hogg, J.C.: Neutrophil sequestration by the lung in adult respiratory distress syndrome. Am. Rev. Resp. Dis. 135:A334, 1987. 73. Dirks, P., James, A.L., Ohtaka, H., Schellenberg, R.R. and Hogg, J.C.: Cigarette smoke exposure causes airway hyperresponsiveness to inhaled but not to intravenous acetylcholine. Fed. Proc. 46: 660 (Abst. #2009), 1987. 74. James,• A.L., Burns, A.R., Duff, M. and Hogg, J.C.: Capsaicin pretreatment does not reduce bronchial hyperresponsiveness induced by cigarette smoke in the guinea pig. Fed. Proc. 46: 324 (Abst. #45), 1987. 75. Doerschuk, C.M., Allard, M.F., Brumwell, M.L. and Hogg, J.C.: Pulmonary neutrophil (PMN)-endothelial cell interactions in rabbit lungs following infusion of zymosan-activated plasma (ZAP). Submitted to Federation of American Societies for Experimental Biology, 1987. 76. Martin, B.A., Doherty, D., Downey, G., Worthen, G.S., Henson, P.M. and Hogg, J.C.: Comparison of polymorphonuclear (PMN) and mononuclear leukocyte transit through the rabbit lung. Submitted to Federation of American Societies for Experimental Biology, 1987. 77. James, A.L., Pare, P.D. and Hogg J.C.: Airway wall thickness and smooth muscle shortening in normal and asthmatic subjects. Am. Rev. Respir. Dis. 135: A181, 1987. 78. James, A.L., Moreno, R.H., Hogg, J.C. and Pare, P.D.: Morphometric comparison and calculation of muscle shortening in relaxed and co6tracted airways. Am. Rev. Respir. Dis. 135: A270, 1987. 79. MacNee, W., Martin, B.A., Tanco, S. and Hogg, J.C.: Regional red blood cell transit times in human lungs. Submitted to American Thoracic Society, 1987. 80. MacNee, W., Martin, B., Tanco, S., Belzberg, A., Wiggs, B. and Hogg, J.C.: Cigarette smoking delays polymorphonuclear leukocyte (PMN) transit through the pulmonary circulation. Submitted to American Thoracic Society, 1987.

- 32 - 81. Doerschuk, C.M., Allard, M.F., Brumwell, M.L., Lee, S. and Hogg, J.C.: Epinephrine-induced changes in neutrophil (PMN)-endothelial cell interactions in the lungs of rabbits. Submitted to American Thoracic Society, 1987. 82. Burns, A.R., Walker, D.C., Hosford, S. and Hogg, J.C.: A study of respiratory epitheLial permeability to fluorescein isothiocyanate dextran (FITC-D) following cigarette smoke exposure in the guinea pig. Fed. Proc. 46: 815 (Abst. #2912), 1987. 83. Allard, M.F., Doerschuk, C.M., Brumwell, M.L., Coxson, H., Lee, S. and Hogg, J.C.: The effect of fibrinogen depletion on oleic acid-induced lung injury in rabbits. Submitted to American Thoracic Society, 1987. 84. Doerschuk, C.M., Dirks, P., Gallo, I., Bosken, C. and Hogg, J.C. The acute passage of gaseous phase components in cigaretts smoke across the alveolo-capillary membrane. American Thoracic Society, 1988. 85. Doerschuk, C.M., Allard, M., Brumwell, M.L., Harlan, J.M. and Hogg, J.C. Neutrophil emigration within the pulmonary and systemic circulation are mediated by different mechanisms. American Thoracic Society, 1988. 86. Beyers, N., Doerschuk, C.M., Brumwell, M.L., Coxson, H. and Hogg, J.C. Morphometric analysis of neutrophils (PMNs) in the rabbit lung after infusion of zymosan-activated plasma (ZAP). American Thoracic Society, 1988. 87. Gie, R.P., Doerschuk, C.M., English, R.E. and Hogg, J.C. Infusion of zymosan-activated plasma increases the permeability of the alveolar- capillary membrane in rabbits. American Thoracic Society, 1988. 88. Doerschuk, C.M., Allard, M.F. and Hogg, J.C. Pulmonary and systemic sequestration of neutrophils (PMNs) during infusion of zymosan-activated plasma (ZAP). Federation of American Societies of Experimental Biology, 1988. ~ 89. Ohgami, M., Doerschuk, C.M., English, R.E., Dodek, P.M. and Hogg, J.C. Neutrophil (PMN) kinetics in swine. Federation of American Societies of Experimental Biology, 1988. 90. Ohtaka, H., Cory, C.R., Hogg, J.C. and Schellenberg, R.R. Indomethacin enhances histamine-induced pulmonary hemodynamic changes. Federation of American Societies of Experimental Biology, 1988. 91. Doerschuk, C.M., Allard, IS.F. and Hogg, J.C. Zymosan-activated plasma- induced neutrophil (PMN) sequestration in the pulmonary and systemic vasculature of rabbits. First Congress of Asian Pacific Society of Respirology. Ln I.- Ln J l0

- 33 - 92. Doerschuk, C.M., Coxson, H.O. and Hogg, J.C. Regional capillary RBC transit times and capillary dimensions in rabbit lungs. First Congress of Asian Pacific Society of Respirology. 93. Beyers, N., Doerschuk, C.M., Coxson, H. and Hogg, J.C. Neutrophil volume and capillary segment diameter in the rabbit, the dog and the human. Am. Rev. Respir. Dis. 139: A297, 1989. 94. Beyers, N., Brumwell, M.L., Doerschuk, C.M., Coxson, H.O. and Hogg, J.C. Neutrophil accumulation and capillary transit times in emphysematous and non-emphysematous human lung. Am. Rev. Respir. Dis. 139: A121, 1989. 95. Bosken, C., Wiggs, B., Pare, P.D. and Hogg, J.C. Small airway dimensions in smokers with obstruction to airflow. Am. Rev. Respir. Dis. 139: A16, 1989. 96. Bosken, C.H., Doerschuk, C.M., English, D. and Hogg, J.C. The effect of acute cigarette smoke exposure on neutrophil (PMN) transit through the rabbit lung. Am. Rev. Respir. Dis. 139: A297, 1989. 97. Doerschuk, C.M., Coxson, H.O. and Hogg, J.C. The site of neutrophil (PMN) accumulation within the pulmonary capillary bed after infusion of zymosan-activated plasma (ZAP). Am. Rev. Respir. Dis. 139: A302, 1989. 98. Gie, R.P., Doerschuk, C.M., Coxson, H.O., English, D. and Hogg, J.C. The role of neutrophils in acute lung injury caused by an infusion of zymosan- activated plasma in rabbits. Am. Rev. Respir. Dis. 139: A301, 1989. 99. Cie, R.P., Doerschuk, C.M., Coxson, H., English, D. and Hogg, J.C. The effect of indomethacin on injury to the alveolar capillary membrane caused by zymosan-activated plasma in rabbits. Am. Rev. Respir. Dis. 139: A425, 1989. 100. Hogg, J.C., Pare, P.D., Wright, J.L. and Wiggs, B. The prevalence and severity of emphysema in lung specimens resected from patients with normal and obstructed airways. Am. Rev. Respir. Dis. 139: A121, 1989. 101. Markos, J., Doerschuk, C.M., English, D. and Hogg, J.C. Neutrophil kinetics in pneumococcal pneumonia in the rabbit. Am. Rev. Respir. Dis. 139: A299, 1989. 102. Ohgami, M., Doerschuk, C.M., Cie, R.P., English, D. and Hogg, J.C. The effects of endotoxin on monocyte accumulation in the rabbit lungs. Submitted to American Thoracic Society, 1989. Ln ~ 103. Ohgami, M., Doerschuk, C.M., Gie, R.P. and Hogg, J.C. Radiolabelled Ln monocyte kinetics in rabbits. Submitted to Federation of American ~ ~ Societies of Experimental Biology, 1989. ~

- 34 - 104. Bosken,- C.H., Doerschuk, C.M., English, D. and Hogg, J.C. The effect of acute cigarette smoke exposure on neutrophil (PMN) transit through the rabbit lung. Clin. Invest. Med. 12: B87 (Abst. #R-529), 1989. 105. Brumwell, M.L., MacNee, W., Doerschuk, C.M. and Hogg, J.C. Comparison of erythrocyte (RBC) velocity to neutrophil (PMN) retention in normal and emphysematous regions of human lungs. Clin. Invest. Med. 12: B91 (Abst. #C-552), 1989. 106. Markos, J., Hooper, R.O., Kavanagh-Gray, D. and Hogg, J.C. Leukocyte retention in the lung during a Valsalva manoeuver. Clin. Invest. Med. 12: B87 (Abst. #R-533), 1989. 107. MacNee, W., Wiggs, B., Belzberg, A.S. and Hogg, J.C. Effect of cigarette smoking on neutrophil kinetics in human lungs. Clin. Invest. Med. 12: B91 (Abst. #C-553), 1989. 108. Ohgami, M., Doerschuk, C.M., Gie, R.P., English, D. and Hogg, J.C. The effects of endotoxin on monocyte accumulation in the rabbit lung. Clin. Invest. Med. 12: B88 (Abst. #R-534), 1989. 109. Okazawa, M., Ishida, K., Hogg, J.C. and Pare, P.D. Tracheal blood volumes in histamine-induced bronchoconstriction in guinea pigs. Clin. Invest. Med. 12: B93 (Abst. #C-565), 1989. 110. Wiggs, B.R., Moreno, R., Hogg, J.C. and Pare, P.D. A model of the mechanics of airway narrowing. Clin. Invest. Med. 12: B88 (Abst. #C-539), 1989. 111. Wiggs, B.R., James, A., Pare, P.D. and Hogg, J.C. The effects of airway wall thickening on airway mechanics in asthma. Clin. Invest. Med. 12: B89 (Abst. #C542), 1989. 112. Bosken, C., Hards, J.M., Catter, K. and Hogg, J.C. Characterization of the inflammatory cell infiltrate in the small airways of smokers. Submitted to American Thoracic Society, 1989. 113. Brumwell, M.L., MacNee, W., Doerschuk, C.M. and Hogg, J.C. Neutrophil (PMN) kinetics in normal and emphysematous regions of human lungs. Submitted to American Thoracic Society, 1989. 114. Doerschuk, C.M., English, D. and Hogg, J.C. Redistribution of capillary blood flow away from injured alveolar walls during resolution of oleic acid-induced lung injury in rabbits. Submitted to American Thoracic Society, 1989. cn ~ 115. Hayashi, S., Kuw ano, K., Matsuse, T. and Hogg, J.C. Detection of Ln -4 ko adenovirus in pa raffin-embedded lung tissue by the polymerase chain reaction (PCR). Submitted to American Thoracic Society, 1989. _J N 01 W

-35- 116. Kuwano, K., Hayashi, S., MacKenzie, A. and Hogg, J.C. Detection of adenovirus DNA in paraffin-embedded lung tissues from patients with bronchiolitis obliterans and organizing pneumonia (BOOP) using in situ hybridization. Submitted to American Thoracic Society, 1989. 117. Markos, J., Hooper, R.O., Kavanagh-Gray, D., Wiggs, B.R. and Hogg, J.C. Leukocyte retention•in the lung during forced expiration. Submitted to American Thoracic Society, 1989. 118. Matsuse, T., Hayashi, S., MacKenzie, A. and Hogg, J.C. Detection of latent adenovirus infection in smokers with chronic air-flow obstruction by in situ DNA hybridization. Submitted to American Thoracic Society, 1989. 119. Ohgami, M., Doerschuk, C.M. and Hogg, J.C. Leukocyte kinetics in chronic endotoxemia in NZW rabbits. Submitted*to American Thoracic Society, 1989. 120. Wiggs, B.R., James, A., Pare, P.D. and Hogg, J.C. The effects of airway wall thickening on airway mechanics in asthma. Submitted to American Thoracic Society, 1989. 121. Wiggs, B.R., Moreno, R., Hogg, J.C. and Pare, P.D. A model of the mechanics of airway narrowing. Submitted to American Thoracic Society, 1989. 122. Bosken, C.H., Doerschuk, C.M., English, D. and Hogg, J.C. Cigarette smoke causes retention of PMN in the central region of the acinus. Submitted to Federation of American Societies for Experimental Biology, 1989. 123. Doerschuk, C.M., English, D., Harlan, J.M. and Hogg, J.C. The role of CD18 in neutropenia and neutrophil (PMN) sequestration induced by infusion of activated plasma. Submitted to Federation of American Societies for Experimental Biology, 1989. 124. Markos, J., English, D., Doerschuk, C. and Hogg, J.C. Leuko4te retention in the rabbit lung with positive end-expiratory pressure (PEEP). Submitted to Federation of American Societies for Experimental Biology, 1989. 125. Tsubouchi, T., Doerschuk, C.M., Ohgami, M., English, D. and Hogg, J.C. The effect of endotoxin pretreatment on changes in neutrophil (PMN) kinetics induced by activated plasma infusion. Submitted to Federation of American Societies for Experimental Biology, 1989. 126. Barbera, J., Hayashi, S. and Hogg, J.C. Identification of the Epstein-Barr virus by in situ hybridization in lymphocytic interstitial pneumonia. Submitted to Joint Meeting SEP/SEPCR, 1990.