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CURRICULUM VITAE JAMES CAMERON HOGG ~

- 2 - CURRICULUM VITAE NAME: HOGG, James Cameron DATE OF BIRTH: December 4, 1935 MARITAL STATUS: • Married to Denise M. Lamoureux, May 21, 1960 Two children - Robert, birth date - May 31, 1961 Karen, birth date - November 26, 1962 CITIZENSHIP: Canadian CERTIFICATES, 1962 - M.D., University of Manitoba DEGREES, 1963 - Diploma U.S. National Board of Medical DIPLOMAS, and Examiners LICENCES: 1963 - L.M.C.C. - Licentiate of the Medical Council of Canada 1967 - M.Sc., McGill University, Montreal 1969 - Ph.D., McGill University, Montreal 1972 - Quebec Licence, 72-666 1974 - F.R.C.P.(C) 1977 - College of Physicians and Surgeons of B.C. Licence #716 TRAINING: 1962-63 Rotating Internship, Winnipeg General Hospital, Winnipeg, Manitoba 1963-65 General Medical Officer, Royal Canadian Air Force, Greenwood, Nova Scotia 1965-66 Physiologist, Royal Canadian Air Force 1966-69 Post-doctoral Research Fellow, Me ical Research Council of Canada, Departm~nts of Pathology and Experimental Medicine, McGill University, Montreal 1969-70 Assistant Resident, Anatomical Pathology, Massachusetts General Hospital, Boston, Mass. 1970-71 Assistant Resident, Anatomical Pathology, Pathology Institute, McGill University Montreal 1987-88 Visiting Research Fellow, Merton College, Oxford (Molecular Biology)

3 PREVIOUS POSITIONS: 1971-72 Assistant Professor, Departments of 1972-75 Pathology and Experimental Medicine, McGill University, Montreal Assistant Pathologist, Royal Victoria 1972-75 Hospital, Montreal Associate Professor, Department of 1975-77 Pathology, McGill University, Montreal Miranda Fraser Professor of Pathology, PRESENT POSITIONS: 1977- McGill University, Montreal Professor, Department of Pathology, OSPITAL AND 973-76 University of British' Columbia, and Director of the Pulmonary Research Laboratory, St. Paul's Hospital, Vancouver Co-Chairman, Biology of Disease - a multi- ACADEMIC ADMINIS- disciplinary course of 350 hours sponsored TRATIVE POSITIONS: by the Departments of Pathology, Micro- 1980- biology, Epidemiology and Pharmacology, McGill University, Montreal Research Co-ordinator, and Chairman, 1985- Research Co-ordinating Committee, St. Paul's Hospital, Vancouver Member, Medical Advisory Committee, St. 1988- Paul's Hospital, Vancouver Member, Planning and Priorities Committee, St. Paul's Hospital, Vancouver / 1989- Member, Natural, Applied and Health Sciences 1989- Research Board, University of British Columbia: Executive Committee for Research Member, Task Force on Promotion of Health HONOURS. AWARDS and 1975-76 Care Research, Council of University Teaching Hospitals Member, Research Review Committee, American EXECUTIVE POSITIONS IN Thoracic Society SCIENTIFIC ASSOCIATIONS: 1975-76 Member, Scientific Review Committee, Canadian Thoracic Society

4 1975-76 Member, National Institutes of Health Review Committee, Specialized Centers for Research 1976-80 Member, Pathology Study Section A, National Institutes of Health, U.S. Public Health Service 1976-79 Councillor, American Lung Association 1977- Member, Scientific Review Committee, Canadian Heart Foundation 1977-84 Member, Board of Directors, Canadian Thoracic Society 1979-80 President, Section on Pulmonary Circulation, American Thoracic Society 1979-86 Member, Heart and Lung Committee, Medical Research Council of Canada 1979-83 Member, Scholarship Committee, 1981-83 Chairman, Scholarship Committee, 1980-83 Member, Scientific Advisory Committee B.C. Health Care Research Foundation 1979-82 Consultant, Laboratory Advisory Council Equipment Sub-Committee, Ministry of Health, Province of British Columbia 1980-82 Corresponding Member, Specialty Committee in Respiratory Medicine, Royal College of Physicians and Surgeons of Canada 1980-83 Council Member, Canadian Society fog Clinical Investigation Member, Membership Committee 1981-82 President Elect, Canadian Thoracic Society 1982-83 President, Canadian Thoracic Society 1981-89 Member-at-Large, National Cancer Institute of Canada 1986- Member, Heart/Lung Subcommittee of the Professional Advisory Committee, British Columbia Transplant Society 1987- Member, Council of Scientific Advisors, nJi Parker B. Francis Foundation w

5 1987 Izaak Walton Killam Research Prize University of British Columbia 1989- Member, Scholarship Advisory Committee, Alberta Heritage Foundation 1989- Member, Research Advisory Committee, British Columbia Ministry of Health 1990- Secretary, Canadian Institute of Academic Medicine EDITORIAL BOARDS: 1978-83 Member, Editorial Board, Laboratory investigation 1980- Member, Editorial Board, Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology 1982-88 Member, Editorial Board, American Review of Respiratory Disease 1984- Member, Editorial Board, Respiration 1987- Member, Editorial Board, Pulmonary Pharmacology 1989-90 Member, Editorial Board, Pulmonary Perspectives ~

6 MEMBERSHIP IN SCIEN- TIFIC ASSOCIATIONS: 1972- American Association of Pathologists and 1972- Bacteriologists: Regular Member American Society of Experimental Pathology: Regular Member 1972- American Physiological Society: Regular Member 1972- Canadian Society for Clinical Investigation: Regular Member 1973- Canadian Association of Pathologists: Regular Member 1973- Canadian Thoracic Society: Regular Member 1973- American Thoracic Society: Regular Member 1974- Fleischner Society: Regular Member 1986-87 Chairman, Membership Committee 1989-91 Chairman, Scientific Program Committee 1974- American Society for Clinical 1974- Investigation: Regular Member Pluto Club: Regular Member 1979- Member, Western Association of Physicians 1986- Member, Association of American Physicians 1989- Member, Organizing Council, Canadian 1990- Institute of Academic Medicine ~ Secretary 1988- Member, Steering Committee, Asian Pacific Society of Respirology

BIBLIOGRAPHY - Publications in Reviewed Journals 1. Hogg, J.C.: A comparison of questionnaire to physical examination in assessing the health of 67 individuals at R.C.A.F. Greenwood. Med. Serv. J. Can. 21: 263-268, 1965. 2. Hogg, J.C.: Subclinical coronary artery disease at R.C.A.F. Greenwood. Med. Serv. J. Can. 22: 799-806, 1966. 3. Hogg, J.C., Macklem, P.T., and Thurlbeck, W.M.: Site and nature of airway obstruction in chronic obstructive lung disease. N.E.J.M. 278: 1355-1360, 1968. 4. Hogg, J.C., Macklem, P.T., and Thurlbeck, W.M.: The resistance of collateral channels in excised human lungs. J. Clin. Invest. 48: 421-431, 1969. 5. Hogg, J.C., Nepszy, S., Macklem, P.T., and Thurlbeck, W.M.: The elastic properties of the centrilobular emphysematous space. J. Clin. Invest. 48: 1306-1312, 1969. 6. Cooperman, E.M., Hogg, J.C., and Thurlbeck, W.M.: Mechanisms of death in shallow-water scuba diving. Can. Med. Assoc. J. 99: 1128-1131, 1968. 7. Hogg, J.C., and Nepszy, S.: Regional lung volume and the pleural pressure gradient in dogs. J. Appl. Physiol. 27: 198-203, 1969. 8. Macklem, P.T., Woolcock, A.J., Hogg, J.C., Nadel, J.A., and Wilson, N.J.: Partitioning of pulmonary resistance in the dog. J. Appl. Physiol. 26: 798-805, 1969. 9. Woolcock, A.J., Macklem, P.T., Hogg, J.C., Wilson, N.J., Nadel, J.A., Frank, N.R., and Brain, J.: Effect of vagal stimulation on the central and peripheral airways in dogs. J. Appl. Physiol. 26: 806-813, 1969. 10. Woolcock, A.J., Macklem, P.T., Hogg, J.C. and Wilson, N.J.: Influence of the autonomic nervous system on airway resistance and elastic recoil. J. Appl. Physiol. 26: 814-818, 1969. 11. Agarwal, J., Hogg, J.C., and Palmer, W.F.: The effect of hypertonic saline on pulmonary vascular resistance in dogs. Cardiovascular Res. 3: 459-466, 1969. 12. Macklem, P.T., Proctor, D.F., and Hogg, J.C.: The stability of peri- pheral airways. Resp. Physiol. 8: 191-203, 1970. 13. Katsura, T., Rozencwajg, R., Sutherland, P.W., Hogg, J.C., and Milic- Emili, J.: Effect of external support on regional alveolar expansion in excised dog lung. J. Appl. Physiol. 28: 133-137, 1970.

8 14. Hogg, J.C., Williams, J., Richardson, J.B., Macklem, P.T., and Thurlbeck, W.M.: Age as a factor in the distribution of lower airway conductance and in the pathologic anatomy of obstructive lung disease. N.E.J.M. 282: 1283-1287, 1970. 15. Pushpakom, R., Hogg, J.C., Woolcock, A.J., Angus, C.E., Macklem, P.T., and Thurlbeck, W.Ms: Experimentally induced papain emphysema in dogs. Am. Rev. Respir. Dis. 102: 778-789, 1970. 16. Hogg, J.C., Holst, P., Corry, P., Ruff, F., Houseley, E., and Morris, E.: The effect of regional lung expansion and body position on pulmonary per- fusion in dogs. J. Appl. Physiol. 31: 97-101, 1971. 17. Schleusener, A., Hogg, J.C., and Thurlbeck, W.M.: Untersuchungen der kleinen Luftwege beim Emphysem (Measurements of small airways in emphysema). Pneumonologie 144: 33-38, 1971. 18. Hogg, J.C., Agarwal, J.B., Gardiner, A.J.S., Palmer, W.H. and Macklem, P.T.: Distribution of airways resistance with developing pulmonary edema in dogs. J. Appl. Physiol. 32: 20-24, 1972. 19. Muir, A.L., Hall, D.L., Despas, P., and Hogg, J.C.: The distribution of blood flow in acute pulmonary edema in dogs. J. Appl. Physiol. 33: 763-769, 1972. 20. Robertson, C.H., Hall, D.L., and Hogg, J.C.: A description of lung distortion due to localized pleural stress. J. Appl. Physiol. 34: 344-350, 1973. 21. Richardson, J.B., Hogg, J.C., Bouchard, T., and Hall, D.L.: Local- ization of antigen in experimental bronchoconstriction in guinea pigs. J. Allergy Clin. Immunol. 52: 172-181, 1973. 22. Simani, A.S., Inoue, S., and Hogg, J.C.: Penetration of respiratory epithelium of guinea pigs following exposure to cigarette smoke.' Lab. Invest. 31: 75-81, 1974. 23. Inoue, S., and Hogg, J.C.: Intercellular junctions of the tracheal epithelium in guinea pigs. Lab. Invest. 31: 68-74, 1974. 24. Moroz, L.A., Joubert, J.J., and Hogg, J.C.: A potent non-peroxidase glycoprotein immunogen in commercial horseradish peroxidase. J. Immunol. 112: 1094-1099, 1974. 25. Coates, A.L., Hogg, J.C., and Thurlbeck, W.M.: Protection against barbi- turate anesthesia death in rabbits. Br. J. Exp. Path. 55: 228-232, 1974. 26. Sureete, G.D., Muir, A.L., Hogg, J.C., and Fraser, R.G.: Roentgeno- graphic study of blood flow redistribution in acute pulmonary edema. Invest. Radiol. 10: 109-114, 1975.

9 27. Joubert; J., Hogg, J.C., and Moroz, L.A.: Rabbit homocytotropic antibody response to horseradish peroxidase: The role of contaminating antigens. Immunochemistry 12: 973-974, 1975. 28. Muir, A.L., Hogg, J.C., Naimark, A., Hall, D.L., and Chernecki, W.: The effect of alveolar liquid on the distribution of blood flow in dog lungs. J. Appl. Physiol. 39: 885-890, 1975. 29. Zamel, N., Hogg, J.C., and Gelb, A.: Mechanisms of maximum expiratory flow limitation in clinically unsuspected emphysema and small airways obstruction. Am. Rev. Respir. Dis. 113: 337-345, 1976. 30. Joubert, J.R., Ascah, K., Moroz, L.A., and Hogg, J.C.: Acute hyper- sensitivity pneumonitis in the rabbit. I. An animal model with horse- radish peroxidase as antigen. Am. Rev. Respir. Dis. 113: 503-513, 1976. 31. Michoud, M.-C., Fraser, R.S., Pare, P.D., and Hogg, J.C.: Effect of indomethacin and atropine in experimental asthma in conscious guinea pigs. J. Appl. Physiol. 40: 889-894, 1976. 32. Hogg, J.C., Stein, L., Martin, R., and Macklem, P.T.: The interaction of the lung and chest wall in dogs. Respiration Physiology, 27: 207-221, 1976. 33. Inoue, S., Michel, R.P., and Hogg, J.C.: Zonulae occludentes in alveolar epithelium and capillary endothelium of dog lung studied with the freeze-fracture technique. J. Ultrastructure Res. 56: 215-225, 1976. 34. Pare, P.D., Michoud, M.-C., and Hogg, J.C.: Lung mechanics following antigen challenge of Ascaris suum-sensitive monkeys. J. Appl. Physiol. 41: 668-676, 1976. 35. Stein, L.A., Vidal, J.J., Hogg, J.C., and Fraser, R.G.: Acute lobar collapse in canine lungs. Invest. Radiol. 11: 518-527, 1976. 36. Michel, R.P., Inoue, S., and Hogg, J.C.: Pulmonary capillary perl&e- ability in HRP in dogs: A physiologic and morphologic study. J. Appl. Physiol. 42: 13-27, 1977. 37. Pare, P.D., Boucher, R.C., Michoud, M.-C., and Hogg, J.C.: Static lung mechanics of intact and excised rhesus monkey lungs and lobes. J. Appl. Physiol. 44: 547-552, 1978. 38. Boucher, R.C., Pare, P.D., Gilmore, N., Moroz, L.A., and Hogg, J.C.: Airway mucosal permeability in the Ascaris suum-sensitive rhesus monkey. J. Allergy Clin. Immunol. 60: 134-140, 1977. 39. Bilimoria, M.H., Johnson, J., Hogg, J.C., and Witschi, H.P.: Activation of 2-aminoanthracene to mutagenic intermediates by guinea pig and rat microsomal enzymes following tobacco smoke inhalation. Toxicol. Appl. Pharmacol. 41: 119-122, 1977.

40. Bilimoria, M.N., Johnson, J., Hogg, J.C., and Witschi, H.P.: Pulmonary aryl hydrocarbon hydroxylase: Tobacco smoke-exposed guinea pigs. Toxicol. Appl. Pharmacol. 41: 433-440, 1977. 41. Barrios, R., Inoue, S., and Hogg, J.C.: Intercellular junctions in "shock lung": A freeze-fracture study. Lab. Invest. 36: 628-635, 1977. 42: Inoue, S., and Hogg, J.C.: Freeze-etch study of the tracheal epithelium of normal guinea pigs with particular reference to intercellular junctions. J. Ultrastructure Research, 61: 89-99, 1977. 43. Cosio, M., Ghezzo, H., Hogg, J.C., Corbin, R., Loveland, M., Dosman, J., and Macklem, P.T.: The relationship between structural changes in small airways and pulmonary function tests. N.E.J.M. 298: 1277-1281, 1978. 44. Todd, R.J., Baile, E.M., and Hogg, J.C.: Pulmonary_ arterial wedge pressure in hemorrhagic shock. Am. Rev. Respir. Dis. 118: 613-616, 1978. 45. Todd, R.J., Baile, E.M., and Hogg, J.C.: Pulmonary capillary perme- ability during hemorrhagic shock. J. Appl. Physiol. 45: 298-306, 1978. 46. Michoud, M.-C., Pare, P.D., Boucher, R.C., and Hogg, J.C.: Airway responses to histamine and methacholine in Ascaris suum-allergic rhesus monkeys. J. Appl. Physiol. 45: 846-851, 1978. 47. Boucher, R.C., Ranga, V., Pare, P.D., Inoue, S., Moroz, L.A., and Hogg, J.C.: Effect of histamine and methacholine on guinea pig tracheal permeability to HRP. J. Appl. Physiol. 45: 939-948, 1979. 48. Pare, P.D., Michoud, M.-C., Boucher, R.C., and Hogg, J.C.: Pulmonary effects of acute and chronic antigen exposure of immunized guinea pigs. J. Appl. Physiol. 46: 346-353, 1979. 49. Baile, E.M., Pare, P.D., Dahlby, R.W., and Hogg, J.C.: Regional distri- bution of extravascular water and hematocrit in the lung. J. ;ppl. Physiol. 46: 937-942, 1979. 50. Michoud, M.-C., Pare, P.D., Orange, R.P., and Hogg, J.C.: Airway sensi- tivity to slow-reacting substance of anaphylaxis, histamine and antigen in Ascaris sensitivity monkeys. Am. Rev. Respir. Dis. 119: 419-424, 1979. 51. Guerzon, G.M., Pare, P.D., Michoud, M.-C., and Hogg, J.C.: The number and distribution of mast cells in monkey lungs. Am. Rev. Respir. Dis. 119: 59-66, 1979. 52. Pare, J.A.P., Fraser, R.G., Hogg, J.C., Howlett, J.G., and Murphy, S.B.: Pulmonary 'mainline' granulomatosis: Talcosis of intravenous methadone abuse. Medicine 58: 229-239, 1979. 53. Boucher, R.C., Pare, P.D., and Hogg, J.C.: The relationship between air- way hyperreactivity and hyperpermeability in the Ascaris suum-sensitive rhesus monkey. J. Allergy and Clin. Immunol. 64: 197-201, 1979.