Tobacco Documents Online

92P ?1.92W Page 1 1. Coordinate Psychophysiology/Physical Chemistry Team for Project XB. Completed "7-cigarette" studies of NOW, VANTAGE ULT, 2-mg XB, Merit Ultima. Smoking behavior, heart-rate, blood pressure, breathing, serum nicotine measures obtained. Mean peak serum nicotine for VANTAGE > NOW > Merit Ultima. XB between NOW and VANTAGE, not significantly different. With Pharmacology Division, completed urinary nicotine / metabolite study of 3-6-mg ULT brands, 2-mg XB, NOW, Merit Ultima in 3-6 mg ULT smokers. Results confirmed "7-cigarette" study. Initiated urinary nicotine / metabolite study of 2-mg XB and NOW in 1-2 mg ULT smokers. Analyses underway. Completed FFLT "nicotine response" study of nicotine yield on serum nicotine, STPI, anxiety, muscle tension, mental alertness, EEG, heart-rate, blood pressure, breathing, smoking behavior. 32 subjects smoked products yielding 10 mg 'tar' and ca. 0, 0.2, 0.4, 0.6, 0.8 mg nicotine. Half of 960 serum samples analyzed, remainder due late November. Other data under analysis. Completed electrophysiological study of nicotine, levulinic acid in pigeon olfactory system. Stimuli showed additivity in mixtures, suppression of nicotine's effects by pre-treatment with levulinic acid. Completed human olfactory study of nicotine, levulinic acid at UNC-Chapel Hill. In general. results parallel pigeon electrophysiology results. Acid-coated filter technology reduced to practice. Volatile nicotine, smoke pH measures, sensory tests showed effective smoothing via vapor stripping and acid transfer. Formal sensory testing scheduled. Showed practical impaction filter can be made with porous paper as orifice plate. Improved, laser-perforated papers being manufactured. Tracheo-bronchial deposition research focussed on developing model system. Results indicate "cloud deposition" depends on smoke concentration, may account for deposition patterns in humans, possibly manipulable by cigarette design. 2. Conduct Research on Product Understanding and Consumer Satisfaction. ChemSense database including physical, chemical, toxicological and sensory data on 1,673 compounds on line. Classes for R&D personnel on database ongoing. Reports on Four-Cities Study smoker personality/motivation, documentation, background, protocol, demographic/lifestyle questionnaires submitted. Report on Nicotine RSM Study switching behavior completed. Report on analysis, documentation of DFC study submitted. Publication on EPQ, SMQ data from Nicotine RSM Study submitted to Personality and Individual Differences. Nicotine RSM data on smoke chemistry, perception of draw analyzed. FTC nicotine, formaldehyde most strongly related to "draw", followed by FTC tar, square of assembled draft. Prepared puff-profile data on 800 smokings from Blood Nicotine portion of Nicotine RSM Study, assisted Analytical Research in completing all replications via HMSM. With Flavor and Sensory Evaluation Divisions, completed study of role of olfaction in cigarette taste. Minimizing retronasal stimulation during puffing caused significant reduction in several "taste" attributes.

92PR1.92W Page 2 3. Support to ETS. Provided design, planning, consultation on five ETS-sponsored studies. Provided > 1,400 cotinine analyses of saliva samples from US multi-city and Japanese non-smoker studies. 4. External Issues. Papers in September '92 Psychopharmacology: "The role of nicotine in tobacco use" (Robinson & Pritchard) debunks claim that nicotine is "addictive" in sense of hard drugs; "The meaning of addiction: Reply to West" (Robinson & Pritchard) responds to criticism of above article: "Enhancement of continuous performance task reaction time by smoking in non-deprived smokers" (Pritchard, Robinson & Guy) shows NIDA "deficit medication" hypothesis is erroneous; "Psychopharmacological effects of smoking a cigarette with typical tar and carbon monoxide yields but minimal nicotine" (Robinson, Pritchard & Davis) shows very low nicotine products had no effects on EEG. "Role of nicotine..." manuscript released (RJRTI) to support opposition to CECCM pack labeling. 5. Other. Chaired HRRC since 1985. 242 proposals reviewed since '85. 36 reviewed 1992 to date.