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51088 3352 1- . r . ... : _ ~.. i_ 1 1_ -11 -j +l I', IJ 1. t_ lij 1`: tll i. ~ ~. .' . r i ~. . r . • r I :il 4. „ 1 J ~.r I'7 . . 1 I• .. : r 1; :.. . . . ' . :; -I_ _a. ~ . :
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The r'harmacolomicsl r-roperties arid clinical cffect_ c•f .._. 1?erizodlacer'1"ies are 3um,i,ar1~•e d,ar1~•ed and Ni::adeliriC's are offered for thL:,., rc3t.iorlal Us2 in cllriical R,edicir/e. After i• brief histori~ al' ~al reviLwi ProPertles are described for chlordSazer'-o:Cidef dlazePamf o:;azep<::m; fliJrazeloiSii arid tilora:•ePa+.e. Action is e::aRtine{; ;•ri ter ms of b2haVicii ,.;i PharAiacoloSl'y t;,i.;:vcle rela>;atlcirt9 arttlconvuisant effectsi circula;•Ion c•~;, respI ratlCZri. 20 references. 1017l2° 0186557 `iIJ1975-07693 Cannabis: review of behavioral effects in arflmals. Millerr Loreri L.9 Drew. William 6. Dept. of Fsvchlatry9 Ur12'versit3 of Kerlti.Scky i'i2{Jlcal C2riter'Y Le::iriAtun7 V, 405J~. Fsvcholosical Bulletin °1(7):401-417, 1974. Larisuales: Er;-::lish Research 'atvd:es coricerning the action of caririabls and lts deri'.'o±.i'ves :::;, rt=Jmerou5 aspects of arilma1 hehavior, irlc'ilidlrlg sroritarceoi.ls a::tlvltyi escct:_ and avoidance ;ehavlor i schedule i Orit•rolled beha'vlory state dc?parii'~'u„':, beitavlorf food and water :.r/take9 arid oi.yresslortf arc r evleiJed. DiSr'=ars:tc_ firfdlrigs are discUsaed and attr Ibuted Rialrii5 to differerices in donai2 ...n:~, e.Cper'1 Sierital Procedure. Tt is au:i ieSt•^d that in a niJRiber of instances tiie effects of cannabis are 52Rillar to those of arttlchollrterm:t drus.:;.. Guideliries for future research are sug3ested. 131 refertrice::. 'Aut,i_: abstrGct) ~ `. .:. 0J,oz--9~. V V l J HIS1975-04359 Classification of drugs accordlrig to their discrlAilrcatle effects iri rat:>. Barrvy Herhert. III. Dept. of F'harmacolonvr University of Fittshurgh School of Fharr,acs,: F'ittsburshy PA 15251 Federation Froceedirigs 33(7):1814-1824Y 1974, Languages: Enflish The classification of drugs by training the animal to make a differeritial response on the basis of drug coriditior:, u_ in, the drug as th(2 discriminative stimuluSf is examined. A discriminative response is established by differential reinforcement in- a oeries of training sessions under the dr'sm arid r;oridrun conditions or under two different dr ugs. conditions with stitiiJliJa characteristics resembllng one of the tralri:;.k::; coridlt:aoria i=ari be identified by consistent choice of one of the alt2r riata.'.;c responses rurin5 tests under novel doses or iir=.;m!'. T hese tests ,'r discriRiinati've ;tim;:lUs ProF'erties have identified the foilowir+g catamJri=._ Of drISS`s: a) central sedatl'v'es9 lriclildirlg barbiturates and the tranouilizers' (chlordia:epo>:ide and 7ieprobaR:ateJ f b) .^.eiitl<"vi c3rltlshol.Iner'mlca (arltlmUScarlrlica); c) nicot?.r+ey d) Tic3r:.ht•iaria or ii;_ coEr;ponent delta9-tetrahadrocanriabinolg c) hallucinoger+s ' (a.esca..iney L'=~.": ,!. Drugs with apF"areritl y weaker %jlscr'I7:IriaL le effects include 1 i chlorproma: lriei the *Cia,•;or trario:Jll:a:er"y and other fit'lenothl.:.:lriesi ...) amphetan,i,ie", and 3) r„orphirie. The discriminative stimu.'.us .-eaa,s to b, .., central driJg effecti' and the differential reGr-uris2 7 a difficult tG establish with Perlpheral drug effects. The review includes di:5ci.;ssiori U~ advantages of this behavioral Pharr„acology technIaue `drid needs for futurc research, 57 references. (Author abstract modified) 1 V /% ! 3 V 0110744 t-!I S1974-00130 The developmerct of behavior therapy with autistic C~ildreri: a revinc». Geller.• jeffres. 2021 Locust Street, Fhiladelphia, PA 19103 Joilrrial of Chronic Diseases 25(1):21-31>r 1972. Lar.svuwes : F.,n: i sh
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222,, 7; 1 rt ~E. S N ° •7 J-V~7v~ Jria revisiori sobre Fara:acologia del Coa.-rortamiernto, ; Behavioral .-harmacclc95: A review. Perez Goriis, Amraro) Garcia-Nerita, M. Luisa, Si:aori, i,'icP;ite u ir'a ieri` j aI rCipa j ri Revista de Historia de :a Fsicolo-lia, 1935 Vol 6(4) 339-366 :otirrial Aririccsricemer+t: 7502 ~3nAu332: Spanish ::ocunerit Twre: JOLtlSNAL ASTIC:.F : r2S2i1++.5 reS:Jits frt'Sm a ttudw of the l..a..2rat+:r 2 or1 b@ha'J2ar al pyara:acoloav included iri F'sjcholosical Abstracts from 1971 to 1930. The most productive authors in this area are analwzcd, a1onz with saecialized reviews or, the topic. (English abstract) (PswcINrO Databose Cop-.-Jright 198° Americari Fcwcholczical llssri, all rights reserved) 22 :"71.2 i '1 -.: 1 7 u ~. i-a.naviCr analvt:c Studi2s uf creativiv`j: A crit1cu: ri?vicint. Wliilstuii7 Andrew .7•; Baker, Joar{rie E. 4 CL2if: f Variad a :aravior Aralvst, 19°5 Fal Vol 8(2) 191-205 ICSiV: .i73,r.~57~9 Jctirrcal Arir:ourice.erit: 740° Lari3ual2: ENGLISH JocuFie;it Twpe: Jt?tJSNAL ARTICLE R2views studies .+.haa.t treat creativitv as or'cra.t'it h2hw'v2Cr. O° 20 studIesf most 7.E't ...inima: r2Zuir2:d2rtt3 for iA2th:,,.''ioao3ica. a~cd all FrCvi:fed c'.'. least sC:12 evidence for increased :.r2aa..iva rcL'rCndiri~9, Ma.tZ.r t,'~.if.°iC1.:,.i2S i:. v,::'.2d P..t2ritial confounds :eti,i2a~i~~:.t ru CtiCr; s a:nd a.::r: 1..ii3~., e-.C i2S 7 1 oC i=• of a'I ir.d2reri'i.ent r2corv of t.-Ii tr i:in.:.! lri~rr3~{.I:i:ii lack :.° s:cia1 validation data, a:iu limited Q:i.1.2rica fGr -D..~rc2r aiizat.icri• :»_;2's +jiscu sSeu iriclu .~.2 Prob12ms iii the b2ilavi3rai definition f1':F Ci'2ativi t-=;l O:S.1eCtiDr+s t:o the use of coritiriicnt r Cii:fcrcem2ria..! and the ric2d for ir:c.31 0nc;jsis of the creative Froces5, (`--jcINFO Database CcF'sri~`t 198i Raieric::ri Fs-=;c~'~clc-aiccl Ascn, :,II ri--31htc reserved)
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s-iriked to atriJcturea svbServlr:S serisl3r'itTi,:'tor iRtelratIVe furictiaicaY 1. , Qriaitl:lri, and threshold redactlt7ri of the ri?IriforceCierit sobatratt• i=301a .. .. the mechariia;i ba which narcotic arlaZlesic'a and CNS stimuiarlta eiiharice ,.k,.. .jC.C..S• rear:Jri=e ratea7 6) vNrJ stlmiJiaritai narcotic <onall2slcs1 i.,..i neiJrolertics pr_bvb1y do not have a a.- _e^ific effact on rewar .L di arid 7) t~~. effecta of ,=hol.rfersicsJ aritlchol.:rier S:ai:s and SLlrior trariZnl iir:ero oi e? difficult to e:.r.ain based i7ri ...^../=a='t ort rioradreriCr$1i= or daTvamirternlc aubstrate. 229 rpfererices. 10/7/25 li2513°8 TAI1977-19375 ."-rchediJle induced beho"vior: a review of its >rrieralltvl deter ^c:.rianva _.k_. !'ha rmacci oli V. C+1 dOtG. Wai 1acer Meredith; Sir!'3ter p Gearge. Itepartrierit of C'='.aholoasY La Trobe Uri:.versitvl Bi.lridooral V1ctor ia 3{'J0:':•> i'1 ust r G 1 i a Pharr.iacolosy Biocher„istrj and Behavior 5(4)I4S3-490;• 1976. t-Or1'uG:3es: Ensl ist...i Work orl schedule induced behavior 5f Iricli.idlri5` Och,3'vi.Jr s oci=Ur r1n=:: ii corijurictiGri with iiorii:orl: "iJliimatora schedule Parameters is revlewed. lk._ topics r arile Fr'Ci°; 4iiieel rUririirts in tiie rat to 3crne Piuvlrit arid 6:aze=G1vIl°i:., '..r1 hiJCiar:a. ~` ar( acolO~lcal variablesY Ir+ciudirig the effects of aerla':iaf:.,l ad(Rir3lstratlorl arid central adCilrllstratlori- of several coidr=c4lrida7 ar e ijisciJssed. it 1= aoricladeJi that there may be either C7uarit:at;>ti'v'2 oi" GtJalltat2've diffe r erice= in driJg effects wilere schcd:Jle iridaced drl'ir=.inJ .. _. corcieared with depriYatiori induced dririk.iris. AAerieral activation t,iew...t a:.hat a;]J4.ircctive i:•ehavior is the result of an iricroa5e in the e;:cltabil:cO., of motor rath6Ja'=5 wi-iicii lead throiJ3ll the lateral =lji=othalaRtils Tia'j acc ount fur the data ereserited in this and earlier reviews but- is too broad in concept to make specific Predictiorrs about the relatioriships betwe: r schedule iriducedy and schodule coritrollecir behavior. bf, refererices. {AiJthoi' abstract modified) 10/7/26 0240362 IFA1975-06535 Rate-deperident effects of drugs2 a review of the literature. Sariger: h. J. S Black.mari: h. E. Dei=o`rtfS;erit of F`=•ycholo3s7 Uril'v'ersit'3 of IilrTilri3.ia^iY F`. C. Bo:: 367f L•irmi.rl--ihamS B1J ._Trf ErlaLOr/CJ . • Pharriacolo?n7 Blc•cheRilstr 1' arld Behavior 4(i):73'-S3 Y 197L. LariSuases. Erloi:sil It has beeii claimed that the effects of aT,phetaTiiries Gr, _•c`iedu;, coritrolled behavior aepertd to a large extent ori the rate of re=?on+:''.i : 7.;, ll orl t r o 1 l.' V, i J i t 1 1J r{ 3. A r C' v1 ew o f t`/ e 1 1 t e r a t ur e sh ows t h a t t'i , e r e considerable support for this hyr^titflea2s if the bchavior is not 3ur=i=res=_L b3 aversive 'rroceduresf is not under tho control of PoLJerfui e::terfi.:': 5t1muli or is riot occiJrring very irifreoiJeritl'a. The e:Ct:•risluri of a•:.':._ dependericy hapothesi= to the effects of other drugs has less e71-ir:.cc-.,l sl.{pF'ortf i"lob:e'.'er. It is argiJed that mariy of the rr:,: edi.ir es used f,_r stiJd5lriS rate dependent drua effects do not firo'vide critica.'l tests of .,~,.. hypotilea'.s. :f it is to L?e shown iJrieC3iJ2'voc'ally that it is rate of oper:.in!,, res?oridiris which determines the behavioral effei'ts of drtJ»y it Ia fc:..i. tilat 'rrocedilr'es are needed lri which other variables such a:: reiriforcenE:O:., freaueric'J ar e more adeCiiJatela controlled. 123 ref;=rerice :. (Author a;atr aci:.' --, i-?:.`i r 0195059 {'! H I.,: 9?5-. 6~~,_• Drug therapy: benzodiazepines (first of two rr•rts). Greeriblatt, David J. i Ghader, Richard I. Clinical F'harriacoloy', Uriitr Massac`usettr. G::rieral Husrlitalr Bostarii 02114 New ErrwIarid Jourr,al of Mediciria ~91:19) II~11-ICjJ9 1?7 4.
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.r. f,"..,r ,q8s 0536624 STIMULUS PROPERTIES OF NICOTINE IN ANIMALS AND HUMAN VOLUNTEERS: A REVIE:: ** NEUROLOGY AND NEUROBIOLOGY VOL. 13 BEHAVIORAL rHARMACOLGGY: TIIC CURRENT STATUS HENNINGFIELD. J.E.O GOLDBERG, S.R. NIDAr ADDICTION RES. CENTER, BALTIMO.^.E. MD ALAN R. LISS. INC. NEW YORK. NY (US) 433 ti44. 1935 ISRN: 0-8451-2715-2 Languages: ENGLISH Document Tyoe: CHAPTER THIS PAPER BRIEFLY REVIEWS THE EFFORTS BY ftCDEARCHCRf, TO ELUCIDATE lUC MECHANISMS BY WHICH NICOTINE ACTS AS AN REINFORCER. A PUNISHER. AN UNCONDITIONED STIMULUS. AND AS A DISCRIMINATION STIMULUS. ENOUGH DATA HAS BEEN ACCUMULATED TO PROVIDE A BASIS FOR MAKINB SOME GENERALIZATIONS ABOUT THE ROLE OF NICOTINE IN CIGARETTE SMOKING BEHAVIOR. THE PAPER REVIEWS THF. STRATEGIES USED IN THESE STUDIES AND SOME OF THC FINDINGS WHICH HAVE ENSUED. (48 refs.) 10/7/2 0536593 BEHAt'IORAL PHARMACOLOGY OF CAFEINE IN EXEE.^.IMENTAL SUBJECTS ** NEUROLUGY AND NEUROBIOLOGY VOL. 13 BEHAVIORAL PHARMACOLOGY: TIIE CURRENT STAIUS CARNEY. J. M.i HOLLOWAY. F. A.i SEALE. T.i:.i WILLIAMS. H. !.. UNIV. OF OKLAHOMA HEALTH SCIENCES CENT.. OKLAHOMA CITY, 0:; ALAN R. LISS. INC. NEW YORK. NY (US) :81-2^3. 1985 ISE11: 0-8451-2715-2 Languages: ENGLISH Document Tyae: CHAPTER (IN RELATION TO ITS LEVEL OF USE IN THE HUMAN POPULATION, CAFFEINE IS PROBABLY THE LEAST STUDIED BEHAVIORAL STIMULANT. THE INCREAS:D INTEREST IN THE MOLECULAR ASPECTS OF BRAIN ADENOSINE MAY EXPLAIN IN PART THE RESURGENCE OF INTEREST IN THE EFFECTS OF METHYLXANTHINES ON BEHAVIRR. AS IS THE CASE FOR OTHER PSYCHOACTIVE COMPOUNDS, CAFFEINE HAI'. REEN REPORTCD TO PRODUCE (: NUMBER OF BEHAVIORAL EFFECTS. IT IS NOT THE PURP0,4E OF THIS CHAPTER TO EXHAUSTIVELY REVIEW ALL OF THE REPORTED CAFFEINE EFFECTS. HOWEVER. IT IS OUR INTENTION TO ORIENT THE READER TO THE PRESENT STATUS or rAFFEINE'S BEHAVIORAL PHARMACOLOGY AND THE DIRECTIONS FUTURE STUDIES ARE LIKELY T0 PURSUE.) (20 refs.) 10/ 7/3 0536313 ALTERATIONS IN SCHEDULE-CONTROLLED BEHAVIOR OF RODENTS CO RRELATED W1Ttt PROLONGED LEAD EXPOSURE fi NEUROLOGY AND NCUROBIOLOGY VOt. 13 BEHAVIORAL PHARMACOLOGY: THE CURRENT STATUS CORY-SLECHTAr D.A.i WEISSr B. UNIV. OF ROCHES TER SCHOOL OF MED. AND DENTISTRY. ROCHESTER. NY ALAN R. LIS S. INC., NEW YORK. NY (US) 407 501. 1785 ISPN: 0-8451-2715-2 Languages: ENGL ISH Document Tuse: A REVIEW OF CHAPTER INORGANIC LEAD-INDUCED CI:ANGES IN FI AND FR PERFORMANCE DEMONSTRATES THAT INFERENCES ABOUT THE DEVELOPMENTAL VULNERABILITY TO LEAD DEPEND ON THE NATURE OF THE BEHAVIORAL ASSAY. UNLIKE THE•T-MAZE SEN.^•ITIVITY OF SCHEDULE-CONTROLLED BEHAVIOR TO THE EFFECTS OF LEAD D()ES NOT END PRIO^ TO WEANING. IN ADDITION. THE STABILITY OF PCRFORMANCE OVER EXTENDED PERIODS. WHICH IS CHARACTERISTIC OF SCHEDULE-CONTROLLED B[HAVIOR, MAKES IT AN IDEAL BASELINE FOR DETECTING THE DCLAYrD EFFECTS OFTEN PRODUCED BY TOXICANT EXPOSURE.•FOR DETERMINING THEIR DURATION, AND FOR ASSESSING THEIR ULTIMATE REVERSIBILITY. (:'.4 refs.) 10/7/4 0536316 EFFECTS OF PESTICIDES ON SCHEDULE-CONTROLLED BEHAVIOR BL NEUROLOGY AND NEUROBIOLOGY VOL. 13 BEHAVIORAL PHARMACOLOGY: TI:C CURRENT STATUS MACPHAIL. P.C. U.S. ENVIRONMENTAL PROTECTION AGENCY, RESEARCH TRIANGLE PARK, NC ALAN R. LISS, INC. NEW YORKr NY (US) 519-535. 1935 ISBN: 0-8451-2715-2 Languages: ENGLISH Document Ts.e: CHAPTER PESTICIDES ALSO COMPRISE A VERY HFTEROGENEDUS CLASS or CHEMICALS. TIlE TERM PESTICIDE OFFERS LITTLE INSIGHT INTO EITHER THE PARTICULAR TYPE OF CHEMICAL OS THE PARTICULAR SPECIES FOR WHICH IT IS USED. PEZTICIDES CAN MORE DESCRIPTIVELY CLASSIFIED AS A('ARICIDES, AVICIDCS. FUNGICIDF^., HERBICIDES+ INSECTICIDES, MOLLUSCACIDES. NCMATOCIDES. RODENTICIDE3. ETC. ALTHOUGH EACH OF THESE CLASSES MAY BE COMPRISED or SEVERAL DIFFERENT TYPES OF CHEMICALS. THIS REVIEW WILL CONCENTRATE MAINLY ON SEVERAL OF THE MAJOF CLASSES OF INSECTICIDE AND ACARICID:. (38 refs.) 10/7/5 0536312 CFFICACY. DEPENDENCE POTENTIAL AND NCUROTOY.ICITY or ANORECTIC DRUGS tx NEUROLOGY AND NEUROBIOLOGY VOL. 13 BEHAVIORAL PHARMACOLOCY: THE CURRENT STATUS SCHUSTER, C.R.; JOHANSON. C.E. THE UNIV. OF CHICAGO PRITZKER SC:IOOL OF M.D.. CI:ICAGO. IL ALAN R. LISS, INC., NEW YORK. NY CUC) 2:.3 279. 1^8Z ISCN: 0-8451-2715-2 Languages: ENGLISH Etncw~Pnt. Tyr-r: CHAPTFR
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traCedY irlicatircn the experimental evidence used to d.?GiOristrate :3. _ •effectiveriess as a tiieraFetJtlc rroced;:re in reRiedying the disturbarif.:i:"L associate7 with earl'j irifaritlle aS1t1sT.. Criticisms which havQ de'velvrcd corice•rnirii use of this techriinue with such suh.:octs r.rs also incluced. The 'eriricir'Zes `afid Prccedures are rooted in eaiFir=c,a1 studies, inc?iJdi:iA ear1'_, workk with arii.ialsY such as that of SkiririerY leadiris to later research irita behavior theraFy with autistic arid normal children. Studies of riormF:: children indicate the iairortarice of the temporal relatior+shiF het«:eeri #•ho child's action arid its effect on the onvlrOriaient. When dealiri; autistic children, the lacL:k of 1ong chains of behavior in the raFertoir<< of the subject must first t:e taken into accouritr and the f-rocedures of oFeront• coridltlorilrit ticefi used to effectlvelS aid hlm in lEarriirrl specific =k11lL> Of ec;ual 1rt+F'ortarice is the developmerit of aarnrits as beiiaviOr thera=:aaV"J:• based on the hsFothesis that bv riariipulatir:3 thc schedules of reiriforcen:eritY the teacher arid Parerit can alter the child's behavior. T;1L riurtiber of successful results to date 31ve sufficierit evidcnce of 'i.;ie< usefulness of operant coriditioriirig arid other s:.i; h techriic+iJes in dEal :.r;_-; with the Froblem of the atvpical child, and it is contended that criticism-v of its use are based on the lack of uriderstaridirig of behavior therary and an urifaRiiliaritv with the results. 72 references. 10/7/31 0110502 HIS1973-14879 Mari.iuaria arid human behavior: a brief review. C1ark., Lincoln D. F'sschic:trs Derartrie.ntY College of Medicirce, Uriiversity of LltahY Salt LUC .., i t'_± Y Ci t a h Rocks Mountain Medical Journal 59(1):43-45Y 1972. . . _fl=ia=~, `or4.~-ruo'~t'~~ . -ruo'~t'~~. 'he current confusion arid debate over the ?ffects of Riar1`uafia <.,ri:: . i'i;.: discussed. Two issues are 1 JEfit1 led as c r UClaa to the COri rC'vei 5=• acute f.erital arir behavioral effects of the dr:Ji arid the cOrt3eCilleriCe oi' .z.ofio-terCi ;Jse. It is contended that much corifusiori cori t+e resolved ::'_; rec0gfiii.ifig the dOsale F-rOblemY sirice the F'{ZtericS of the drum 'warie:• -•_ areatly. T ie Gehav1ora1 t:r?t1c1tS of the driJm is determ?.red bS dGncote 'c:n:.'i the iio~ .iJrBa ~.iJrB C t~~ ~2 tasks L i . r aieri .: OF~(?ra IOriS Uri• 2r a~'•.Eri : J•Ji .i.n.': irltOi:icc•~.tiOfi. ns=e'aSS'.ierlt of the 1~•ir d-tpr:k effects t'lf c•iri:ic•LZ:s FreF'ar :tiu;-i is far c:ore difficulty and will rec+uire ^GriSlderab1.y more tlme _...•J1 researCh. A few observations of the effects observed in some 1 1'ris-tE; iii users are riotcdv 1riCiu•.:lrit the trend to social wlthdrawalY 4:ari..Jier 1;i:::i F'assi'vitsY and rreoccuF'atiori with inner e,:rerierice. ?ri order to fulY.; understand the e,:tef t of the PrCble7i arid come to a common tJridersta-id:.n_2. howe'-:erY it .__ riecessar_ to search for r-ure calture heavy marihiJaria u_..:r:.. arid 3aif+ their COOFeratiOri in studies irtvOltlirig serial asGesST+efit of meri::•c. 1. Statu=• afid Ir tt?11ECtiJai Zbii:.tic'C. 15 ref'reri•'"'ES. 10/"3: .. ~ :1J'95163 HIS1973-02503 Behc•'v'1oT'ai t0::1City. fur/ctlor,s• .T.E 1 Mast= 1 0? Pi?r t 1• •Jef.Lri:tlorl a iC1 E ar t r• A1berto; S1-iaterY Richard I. r, •= '3 c/ 1 1 G t ry PC pt. Y `•J f ts M ed1 c..J 1 al. L i/ Q V 1 Y I I Gsl. Tn: S71adert R.Y i'sscllf:troF:i= drug side effects i<ait:.T.ure4 :4iil..am... : Y•1 lF•.ir1sY J ?7V • 2?V f. ( l' • r:.'l- 13i! • Larii'Jsie= . Lr{g11 sh The nature i.+r bC r al tot:ICitS in 'ierta11S or eid0t1u .,~ ~Ia':i~7 ~ia11`] ~J1avuT'bL:.1 :'erSofis brJu=:rt Grn i.~y the ad6.1fi1strat1c7r1 of F'Sychf?trOF2C iJriJms is (jeF.nadi:3fld Sf=eCIf1= tff'e'C ts ofl 'r»chGmatvr functions are descr.ibed. ije`ia'v1t71 L 1 :.o::ic:t.y I1 a phrasc used to denote those Fil<::rRiacOlom2La1 aCtloris of a d;w_. tilaty wheri a•J,:I:ilSte.^e•."'; w:t:llfl the doSage rarise in whlCh lt has been fC..>h..' to PCSseSs clinical utiiltVY PrOd'Jce alterations in perCeptiJai c:.drFitive fu,icticirisY PsSc~i7ii,otOr r'er fClr{TiafcCeY Rii:t1'v'atlGfiY mC:odr 1ri~erF=erSOreol' ~ 21o~S~iiiSi~Si-SY Gr iritrai-5schic rroce5se5 J• 1-. - 1 1 11 .-, 1 1 4 - -& - ..F......., ..-0 4 7.. of ar1 1/ /rI l'•l A•Jual l•l:
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FROG: 28 AU - Weias D AD Environmental Health Sciences Canter. Universitv nf Rnchester School of Medicine and Dentistru, N.Y. TI - Environmental contaminants and behavior dir.orders. SI - TOXBIB/88/003960 SO - Dev Pharmacol Theri VOL 10. ISS 5. 190?, P3!6 5:~ (REF. 12) LA - En9 AD - The discipline of behavioral toxicolo9v is an acknowledgement that behavioral assessments should rlax a role in judging the safety of chemicals. Such a role is emphasized bv the to;aicolo3ical histora of many different classrs of substances. These include metals, insecticides, volatilr org.•nir solvent,, and even food additives. For all of these. inci.ient toxicitu often takes the form of subjective cosrlaints that ate later followed bd overt impairments. The fetus and srounM child seem to be at special risk for substances such as mnthwlmercurv c:nd santhetic food colors, a suscer•tibility not fullv recognizcd. MH - Animal ; Environmental Pollutants/fTOXICITY ; Human i Mantzl Disorders/*CHEMICALLY INDUCED i Review C Review. Tutorial : SuPPort. U.S. Gov't, Non-P.H.S. i Support, U.S. Gov't, P.H.S. 29 AU TI - Van Putten T D Marder SR Behavioral toxicita•of antirsvchotic drugs. SI - TOXBIB/8'/308060 SO - J Clin PsvchiatrYi VOL 48 Sussl. 1^8'. P13-9 (RFFi 54) LA - Ens AB Extracaramidal sym.toms cause much miserv, often go undiagnosed, and rar. interfere with treatment and rehabilitation. Akinesia is a behavioral state of diminished motoric and •stchic srontaneitl that is difficult to distinguish from the negative s~:mrtoms of schizorhrenia. The most useful clinical correlates of akinesia are a subjective sense of sedation and e>:cessive slecrins. Ak.inesia interferes with social adjustment and say manifest as •s•ostPsvchatic de.ression.: The subjective restlessness of akathisia is usuallv accompanied by telltale toot move.ents2 rock,ing from foot to foot while standing or walking on the spot. Akathisia is stronglr associated with derression and di+r•Fhoric responses to neurolertics and has even been linked to suicidal and homicidal behavior in extreme css:s. MH - Basal Ganglia Diseases/xCHEMICALLY INDUCCR/DIACNOSIS i Desressive Disorder/CHEMICALLY INDUCED/DIAGNO.^,IS i Hkrman i Psychomotor Disorders/CHEMICALLY INDUCED/DIAGNOLIS : Review I Tranouilizinj Asents, MaJor/SADVERSE EFrCCTS 30 AU - McKim JM ; BradburY SP G Niemi GJ TI - Fish acute tnxicity syndromes and their uso in thr OSAR acaroc.ch to hazard assessment. SI - TOXBIB/87/246479 SO - Environ Health PersPecti VOL 71. 1^07. P1'1-C(. (REF: 99) LA - En5 AB - Implementation of the Toxic Substances Control Act of 1977 creates the need to reliablw establish terting •riorities because laboratorv resources are limited and the numher of industrial chemicals reouiring evaluation is overwhelming. The use or ouantitative structure activity relationship (OSAR) models as rapid and rredic•tive screening tools to select more .otentialli; hazardous chemicals for in-derth laborator!e evaluation has been Prornsed. Further implementation and refinement of ouantitative structure-toxicitsr relationships in aouatic to>:icology and hazard asse sment reouires the develo~ment of a•sode af-action: database. 41th such a database, a aualitative structure artivit,i relationship can be formulated to assign the sroper mode of actionr arrd respective OSAR, to a liven chemical structure. In this revieu, the develnsment of fish acute to>:icitv syndromes (FATS), which are toxic-response sets based on various hehaviaral and Phtsiolosical-biochemical measurements, and their nroJected use in the mode-of-action database are outlined. l1sing h.havior:,l Parameters monitored in the fathead minnow during acute to:cicitu testingr FATS associated with acetylcholinestera`e (AChE) inhibitors and narcotics could be reliablw fredictrd. Houavvrr, comFounds classified as oxidative shosPhorslotion uncouslers or stimulants could not be resolved. Refinemnnt of this approach b•s using resriratory-cardiovascular resoonsee~ in the rainbow trout, enabled FATS associated with AChE inhibitors, cnnvulsants, narcotics, resriratorY blockers, resriratnry embrane irrita:,ts, and ur.couFlers to be correctlu sredir•ted. MH - Animal i Fishes/tPHYSIOLOGY ; Lethal Dose 50 : Rcvieu : Structure-Activity Relationship ; Water Pollutants/lTOXIfITY 7 Water Pollutants, Chemical:tTOXICITY
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l. `t ~.i~L'T 1: G`1. t_ . • `_i-/" ', t li.a ,Li iO1Y'1 L . l 7.7 • "ir iad:•/'s ,}]• c ~i a r '•_~i i • ! i!~J \ r+eat-i:o=-P=rr: Medical Health .r•,tr 9ChII"t.i'erc/'a Scr•viCesi• L+:caL., rr\'o"bury7 ^"rri2ricci: ..r:.i~Jeriai ~ or E'~ ~ -,n.f='ila+ vra, 1977 ..~v.. 134(7) v ./ l Vol 79°-v~`~'.:. 'r'r .~ .!our rca.1 ArrrroJ.•ceT,e;rt: 5906 `orisuage: ENGLISH Docu.r;er:t T,pe: JOURNAL ARTICLE Prese/ i t s a • e•v A•C'' '% of t i iC l 1 teratur'e J r/r 1 L at Z rig vr ia t a L t1IL•uth U r i t i lii a 1 a r I G i aa ar i ts L i i 1 V r V• Cui ri t, i/ytJ r o r avL iZ 1 o r rd Lr ui r{ E.'• 7 a i 1 rJ a3 r/r Vdi u au.. r ie . e I ._ 1h/ i•J e I 3 'J w ed to t reat a vG r j e t:7 1.~ f ral e iJ i L a 1 cor i rJ i t+or Vs1t i• /l a1 t toiilcJt= and lC'tilality are ri(Jt SG'rierally r.:coirll:edi A r..~•'V..aw is rr__-r;t...•,r of reported over di.3"oe':.• Therapeutic doses zOT:et..°r:es C..%JSi i's'__hv=,..-. de l I r I iJ m, P2 r = o rl a l I ty : i i a r ige, a ri d Since T:'t ~ de:-rea.aloii• vlrii::: o•J2"at2ly .r. .. o•ver:ose5 of a=i"SloroD'u'irie ccri result in ra: ld death, It is cori.aidar,:•'' t50. 3iJCir .^•eha'v':aor =1 2ff=ct5 C.iiJ.Ld lead overdosz5E and death. ,61 ref) t0 aa_r.1 Lri o ir suor.c'._: Cpei!:_,.. r:F-. "^In/~ ' ~.~%12 57-Q9°2,3 Behavioral Pharrsiacoloon and toxicoloss. Rigriarii s C. Inst Superiore di Sariita, Lab di Chiaiica Terar-eutica, 'F:ome, Itsl•_~ Annual Review of Frhara,acology 8 To::icololv, 1976 Vol 16 329-366 Journal Arir;o+Jricer:erit: 5705 Language: ENGLISH hocuaierit Type: JOURNAL ARTICLE Reviews the literature on the behavioral interaction of drums which h•s;'ve an aritipuriishrierit actiori• specifically barbiturates, berizodiazepir:es, .•`•;-ilydro:"ytr5rtamirie (5-HT) syate:a amentLr RCaeareh with oPer'arit JsiriSi ="C•S.it1've i'elrifoi'ccl712rit shows iRii=:.irtarft rJJiffererivcs botii wit:'l1+'r Lrra `,E' ., • wee~i Crv3 =:rOiJp:. i•a3rL11turate and borizVvia::eF''Ie'iC-' affects iJil L+2Kovi. •... mod:fied .1= i-uri1shRierit cannot be e::}rialrced ori the L•a:is:a of a tTtodel of drum action but Ciust take into account treatmertt faCtoT . Jrgarii5<<ic F=ct'v'r:r, and test factors. The same ..:> t: .1e of : 3hl..r ... ;mciiritairled :?y e'fegatl've reiriforceRierit. icha•v'lorrl data i"e=tir,ar•.''z,ir{g the `'-.•'i hypothesis of trarcCauil2.'_er effects also siJr =:,r t the rreiTi25e that ?IC.. .. iTi ode l a G f OTo1" a c:• i r1 r1 si1 o iJ l•.'~~ ri o w [`'.• e r e F• l ace 1 b5 'Si iJ l t: f a c:• o r.i sl W nrk.l r t._, h3pottieaea. The to:...coioilcal :.?:pl Icat:.oris of the stiai:Jl .J is ~r f'J.cn...? ~ n= -.- driJaa arlv i=ileTric.:lS or ediacu'3aCCf, and the aff(3Ct:, of t'r 2risva•l and eoi !_ F•o'=triatal tr'ea'tirrerit= w:til rrsycaotroFic uriJg:; and : F i'e".:•ti:: Iti?sv 1':. ...r c; t t~v i t i''e_•c "'1ei ~:iJrt~, cnr 4~J 1E'4;d ai'e e;:6•'..iiinc4::. l-i6.7i re'f, l 22i 7/i3 '1L• ~r~V - V aJ .a LStutter arig and the C+ei aviorai rriUdt'l. v a r 1 t: e r : 7 1'. a ymoi f r_i Fe U. /`-, kr :; f i Acta S•3R;bolic2:, :97!;y Fol, Vol. 1(C), 47-";,3 JoiJrrial ArirloiJnceG;B;it: 4602 Lar7~~Jo~' 'E'' • !~~i~• .. E?''riTcH ~~JCUr~erlt r • A` AFiTTrI~,+=y r ~ Tjr''2a' JQ;JFi~`~r_ r..v~, riEial~=;+: : tnutter Ir{g IS a speech disorder whose orlg.:rn rE"faalrln iar^.:•Ll L .t,!•..rI '~ ~Jr•VM' . • De'fSriItILL'e =_tatel,tertt3 c'oricerriircg the use of behavloral tc'chrilsiJe=• are rFot :darr'arited .:•'j the review of llterati.ar,e r• a-=eriwet r. .,.. orerarit behavior modificat.iori techriioues ar'pear to ae Riore ,-rcr.iisir;, t.,,._.•n deseilsiti : at;.ori and other Pr;'}cedure5 whose focal concern I" with ari::Ict_ a! feai'. There is evidence that the 'vrar ZoiJa syZ4ptorts :~ .~1$r- .l..o~.~ ,_; ~• 1-;r ':~:.v St=Jtterer ore furii=tloriallJ irideF'eriderct. It is sug3eated that =•`:Rri-toT1a i:i::;1 be ellyd:.ilated :'nirouSh direct application of i::ariiiri5 F'i'iril=7: i::5. :39 ='i - 2.ry;/ 7• .I^r '45- Y' ..T! 1 1 V E::r erlCierital cffect5 Gf aRiiriietarTiirle: SiJr=PleiTrarltary r'2=Crr',;. r.:~~e, rr cr-.e.'..:C~~~ _•J ~ r_,_• 0. E1Jtsers State U• . wa°rideri7 N.J. i•erc2r tiJOi aY MV t{J r .Jki 1 a"_•, j 97J, jo•J r r i O 1 !'I r r a r e.t uri t_ ci.i G i'i l• • 450Z :.. ar iauc•Ac• : .r• NL:_ i,="H Lccua.erit .-. _ : 1 -_ ks-. -. a'n . . .:. i` M. . . T.jf C • ~ '~'i9Z-rVn ~•J-to Y1~• 51-.1i 31(l), r2 ~~ aJ n /r J V Lrl\/[Y•IL r1r't T T V`L lr.n V Dl. yi • FMDW: rr
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-.r.'•e%srtmcii} of P;sc_ili\3tr -:Y Jan D:amv V2t1?i siils AmTririlstrot.l,..,, i' 1 C V A L G 1 CE: r r ter Y L G: jL1 J a G.r' V G t Jfll rr/ l G. T i -•l t Cur;i 1 e i' v i.- = ari d •'-< lt C• r r i O l• i'v e trL o tme r/ ai. s. r i a r 1 aZC i.. C' nt a f bCl i a ti i 1 ra.. '--itp:.oGt= and Fsyci1;75i= in Alc.hei?icr 's disease and rCi,3t.:d c:.l,^I t.".v. 51 - "DXBIB/2°. : 4,4L1 ~.~ D - rsvch:s+ ,.r Cl•ri , ,z,; „~ i~nL 1 .f ~; ..: iy 19° ~3, F;~ y"c-... ~,'~,..;;iti,~: ~ ,!crt;~ ;i r" .D .. ,.-. LA - Er.~ rr~B - F<c^ha'v'i•'•~r vi i=,zb1eiT1s1 and even i=s'j.:iiotic Swm7 toRlai a3r? Ur.i'ver s.:..,._...r :_'•cE•.no.J:ev3ea vs a7il::ilg the Cioat dlatressSrig corfs2aui?ric2s Cil ac•meritlc. A mc...:or .ity of Patierits e::i=zr ieriC'ie e3.tiler or both ...:: s.-rme t.j,i,e dur 1 ! {g the L o{.1 r se 1-•f l.jeil.er (t 1 J . W'+-i..!'1•1~~5V/+ 1 '~: -i so L~~_ '!~ 1 - .~I i..lJ ~. t• \. f i that accurate i-r'ev31er:ct, ratea ar e diff:L'Uit• to a-c.:'rtairii t,,... c• -~,. ~ n vaila~•1G ~.JOt_ 1:~53est oppro:,ir.latel a irlatela : to .•('! rer ;ert i.:r .'atlerits 1Tiar!Zfast this behavior .1ri soT,e for SI1. F'a'aci\:itac a;mFA;,Un- ,ri soTle forr,i occur less freauerltlvi but Per,iar's affect 'Ji' + VJ i /v.;' of r3CTieilted f=.: alerits at sC'+iie tlme. Neuroloi'tic medilL'..-tiC:rls i.:i'i:: fTlorig she P=•yt='iioai=tiVe drug'1 most freat.3eritle Prescr ibed for :',h._ deRiercted Ei•:3erl'.v9 met they C'3rry the rlsk of corislrjer ab..i:.` mGrbid: ty f r::f,T, -id+e effel_ tsP both o\=ute ((?i:trairjr ai:liGu% s:rlrrories;' carQioVa=ciJlor toAClcltav arttlc7ollriergIc effec_ts) chroriiC .tardi'.'e desklrleslal a Then are most w1:eZd us:?'•.i fCiibeha'vioral and i=sychotlc s'd7+pti3lTcaY h'JweVer y thelr effic._.'-, ra,- ri'Iese Pr'abiem3 ..s far froRi tlrceCiu..Vocai1v establls:iea. Th;:o multir'le medical ,=rvbIems of the elderly add to the cor,lr',L:...ty of ;iaS:ios:n3 and „ailagirig these syiRPtoRis. Systematic dl?llne.itSoii or the etlulCS•_r cviJrsey arid rrogrio3ls of behaV2ora1l and .anchGt.....c sya,r-tor:s rl:3n clarify the indications for such treatmerit. F'., rtWreSearci-J on effective adJUricta and aiterri3t.1'ves to ri\''uroler'':.:.,.. 'it r'eatiS)erlt .tri the :7i icarit''•d el deriy may f3.:3, litate rr.:tic:r{i; {Iiarlalemerlt7 ma::2^il.: irig effii=ar_3 and red+:i=1r1.: i'oterltli•1 at•ver._!.- cor•StC.oer1cEs. MH '- Ag'^d i t11z:lelmei''s Dlaaasei•wvDMF•LICAT.Ti\JiES 9 Human YM:d,Jie ri1L . F'=_•ychorio,or A_:itatiori/*DRDG THERAPY/ETIOLOGY S F's•jc`o',:•i,_ ;i~1 r'~-:';~:rtF:Llk T! ~'ERAF'Y!ETTO' OGY 9 F:e'~ iew i 40 . ~i~ ir .~t~ L y ~ vi e« 3 Ati a;Cii. i i: . .aiJpr i1 r tr V. 1. O_'V 't i 1'<orl -P. N. S. > T ro:ll.~1./ !! J z1 r{, A:]C. i ts/ 1 iUv or. ADVERSE EFFEC.TS,'*THERAPEDT.T.C USE -, ; rl V - ..C! i. i/ a2 l- !' 1 i..! AD -.ribcr'-Je+.a'- Ltd. p Base: y Jw2t.'_er laild. TI - hE'F..e=t:.ris fiJiict:orial rle+jr oto;:Ic.it, :.rr the course :.F a:.fct'..; e4'U1 iJQt:oris wi :•h l::boratory ari:Ric>i s. Di - TDkBIE:: 1CJV/2365.-> SO - Toxicology: VOL 49Y ISS 2-3. 1988y F'409-1:, (fiEF2 37) LA - Er;E; AR - Iri the course of routinely eerfora:elj subchrGr+ic t(7::ic:ty studi`_: 1 / H ade•?.2a fRGdr2ri:'.i_o ; Startle Rieectt_ar1K:rl`U.G Ecri-.EuTS i Jvi-:'o *TGa'iCiTl ; i.rc'r•:'t7u5 .SySf.em/*itFi`U\.3 EFFECTS . R;rVleW % R.:.ri+.br: 1+it h laboratory roder{tai functional rieurotG:CS.::.twi I.2. i?eha4'aoral charlaes are Usualiv r/ote~''~ first !'jUrlrit tiic di.1iy come side observations of all oriirtlols. Observation ar/:_'d s;:Li:JeaUe/{t rleiJr olo3ic examination of a few key arilTial":. e'-'roVldi-' o f'r :ric;i -; tentative diagrlosis. Additional automated tc: stirl! zi%.!3it inclui.': motor activitv, startle reseorise9 hurdle sttrpino and r/aze Jc'ilaVior. Automated teatlr{g i=ro'v'I+=ies f'.rthCr refirieT.a!rit of ~,~r... i2anrios.i= and aer Ves to determine tire ri\.'\i iJL•:-41'YU1~• ~.~\- ~ affect _.a 1C''r1_.._; ~. inaer condlt..oiis \=f blind i,2stlrim. BLi,3vl;1rs1 [=iiari:aes should 5\.. 3=essed as earls as Pa3a1b12 ofter Irc.tn at:aori i!f testlrln i.\_. ,1rz,is ac:te tests for r!l,rtality and the f.:.llowirig sabc`rrc:iiic r_r.=:e"fi,id:.rf3 =1•;1dit's. .~7Ubsei.Z1Jerf± aui.~•chrl7riic orgari to::ici&- s~,~.ur2es aie theii carried out Oy foZl.:iwlri:3 a volad i2::Fi2r i:rc::,t...... :'ust.:rCvl fai' ir,ii=l2meritatiori of autamiat\?d ti?st:.r/s i=r o\:G:jur Cs c•n-i v P- pr tJ r r i C? ,J e rl C•J { l. ra t rl U 1 ov1 L. e V 6 1 i.i C+ t L o r{ . AbrI tJ r mG i 1 t1 Lr•' s) L' r iJ A-j rl J L! L e/J /E T 1 O L 1J (3 Y / A. 1.l /11 a.l / B1I 1 13 'V a v, y i'l ,, 1 i, .._ l. DPFUU EFi ECT.."i 7 CoriU:.tlorilrig lr•syc:fll.}L\.Jg::Ji,rDi;..iC E.-r'rvTS 7 DpU_:_:.•
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52 ttlril 37 ,=Qrist,it+ltC a "7azarr to illa r=h'»ic=ai we i.la 'h2:.rii. hir/tiAsych:Jt:.,... *3 rl t ide r rc=saii t? a r i d sr; t i a r; D4 i e ty d r ugs c c3 r/ a i? c i. ii Zbi t b2 i! a'v' C ri a i t v:: i c it'..i . A brief review Cf the i iterature is Pr'GL'ided to -•iloW the F==chsm3a•C ; 8sre.^ts in which these 7rU» iRterfer"e with m1.Jscu:ar acta.V:.ts es F:=• 0 >'E's'rOriSe t= r?ri . rCri7;2rltal ati7ivl i. T lC'a2 1r:Ci Sde r2oOtior/ tIR.2 Y dv,:tcri :-... s''eed of 6ctiVltsi and steadiness. CGrisidC'rabie material e:::.sts 3h"w:Lk_i dru3 induced decremtrFta in ZabOratOry tr=''ats of these oi•.ilZ:ot i=arta..aiwi-._._ ir/ the areas of aLJt1J/TiVbiIa and 1rldSiJtrla: Jl.rlder;ts• 34 references. 10/7/33 ~ / V / W TIS1971-C6064 EACperimer;tal effects of ad.frSetaA,irie: sUppl2iLerttary repCrt. Go:.Fs Sr<erwoGd G. Rt.:tg2rs Urii'v'c'r :ity1 South jersey GaT,i=usi Ca7.d.."~.rti N?b: .iZrs2y 03102 F'er'ce'rtual and mt 1IA ~,1 2'~,Z _t•lz` 1970, D vr Q lr-.~ Z J1 1';1)'• .~ J , iortguc-gES. nzi 1 Oi ii= a =uppZe7:?iit tv a i=re'viOUs re`+:ew/ gerieral.I:atit7ris r eiated t:7 t~._ t::'=erime';tal effects of a7;i-hetaTilr;e Cri food Z,otlVate+j Gr'-2rarit L•2 ha'v,.i: r. b::."t..liy tr-;cti'vit'C Gr/SJ avoidance 1_Cr{ditiCrilr,g in rats ari.., A.lce are e`:aiual,:..~ i.; t2rG•s of recent c'widence• Acceptance of gerterai2zatior;s reiatc'•.'~d to thc' drt'm`s action Gr; such behaviors re7illres that one also accept r;U';rro:.... Cil3aZificatiOr:s or liCtitatlorts in terms of drug dose fact-ors, S variablLvr and task characateristics. However, the desirability of auch, geriera2iZatlCris is stressed. 64 referenc.n..s. (Author -:>b>troct)rc 10/7/34 0051457 JIT1970-02282 Behavioral Pharniacoioov and toxicoloov. Weiss. Berrtard; Laties, Victor 0. Dept. of Radiatiori 5iology and Bior-hvsics;' Univ. of Rochester School t" Mc''dicirett or.d icr;ti_tr::f F.vc{{ester, N• Y• Iri: Elliott, i-i. , kriritlal review of eharm<-,colony Palo A.to, Cal.f. fiririiJai F:eVie4lai 1969. 591 r'=. irtOZ • 9. (P. 297-326). Lar1iuc•5Ez: Er;siiSVl Ti'ie ruG;iric:iit t:teC;es in this review grOw out Of the cUr rc'rtt saari=h °c: LC'irreiat:.uri1 betweeri ciier,i3tr'3 arid l~.•eiSa'viCr. .~.~ir;e 1n tih role of adrcr;e r~i... caechar;isrs in behavicr. The other is the erthanceTient c'f learr;i,;g by a ::•rlgirtali'1 ciai med to affect riborii.lclEic arid (RNA) in the br air,. Bot, :tJr'vesa Urider=zCre the rieed to Urider star;d the i:•ef1aV:.Ora: tieCiiariis7,5 of dru::; i3ctiCirl. ET•pharis i=• r=iaced on neuroci-ie6iicai correlotes of .:•cha'vii::'. Codrer;er51C r'_-Ster,;:-) 1der'-.l.etiCri Studiear dri;g 1rit2ractlaris, the saar c i ra'(' rieurCi ie^l:.:a.l. cCrreiates, oehavlGral e+rfecta of r-eiiioilrce wlth m:Ar;e=• iu;-,; hydr0>:IdC, studies of ieilRiari b2i aviCr ar:d i•ri2iffa.ll bet'iaVior, beiia'vi.:ii ::.: FaramEtE'r = Gf drUn a::tiL•r;, sirid lEiia'vioraZ tCi:lnClCn'3• 137 r tfer@rtcess 1v% 7/.ZiJ r-~.r.-'5.lv`.';= JIT19l0-01..Li93 Effects of triJl°_- Gri avoidance and eai:.apC lie fa'viC1r . r~._.-•. .-~.iI~, ~. 1Cvrivr•..^~) ~. CG~+Gr i1 'c? i-i n• ~- (` ;~lar . l• ~%c[_':; ~~r•. r .r.! e = t , Cf NEiJ"o~ lG-~'._ - c:-i+':..; ' Gard:O,i '- i1.e irielirie <-ri:.. = Fr -ci'7 LaC•oru+ t.S'~, Srtitic ~~iici'7~vrii..... F'P;iladair;-.ia, Pa. Feder'Gtiori F•roceedirin= ^3(i).°1l;-835, 1954. L-Gr.guG'C.Cs: .-"zA1 ° _~_,-, • . I/vV 1'JC / IcC -^f •J esL Q/' C r C?r V rt ses 83 e„Qlitf 1 es of Vt pr{., 11 t (.•e11,r v J V r •,.. ,,.. fi3tJred r ior•I.e;CGt!'-. in st'Jdi2s of r' •Ai'10rilarrlaLUlCaico.. overlts• ~~J.{e.... s::iUirrlcl r;cr;E;e:''n and rats, a few ofthe :=OT,mGr;lid stu&.i_~`i ,e l~ 1_.eer{ ae1 G 1 .-~1-+ 1'e•,J J / -r rC:•fv.. 'eV~ tV 1 a. a. ../ ~ V ;1l. -+ i a1 1- / 1 V r i i a r rl ; v L 17 l L~ > 1 ~ C1 C~ ~L• ~I 1+ V~ f 4- 1a' V .FJ / G G.. ~ various ov=ecva C ir1t2ra0 ZOris GQ weeri ,'u._-"a ari•..i ::•i:hoVii.r• TiiC':a .i.opc.t- iric:ude t`;e apecificity Cf tile sur=r=re»iOri Cf a'vi,idanca raia4'ivr by dr .,n. relative to the 1u='rresalori of escape or other ccZ^.::urri:rit betiavi'vr: '! the role of ~•aSc:in2_ of _ d2+ ~crif.iria,t '"t dr~.3m effects. ~~° i'~~cic a'viCrti ca'viCr ':. :~ o suPPre55o'nt OrreCt'.S ;7F ch.IJTpT'OR:o"m1ne ^vTt avoiJVnce b::i:aV?.Cr, f:•r e;:aMFI.i::: F.-...e .-.r.-._... - 1. + _- -.-. .-+ _ -. -Ia ..--M- -.f ~...r_~.~. -e..+ -l r,..- ri. l . - - !-i--. ..
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dJ _ - .+= ae=cr a:•c•J. PanCVric wcrc trai~fcd to f=ec~k a resi'Gilsi= +.J.iav.'.+ =aa =on=iatin; _f :idi 13ii ~ lL ~ la~~• Various r1~.Lat1{.f1 fs1+1('s • •. ~.ai ia'C•: i .~.'~iti~. +Ji_~/'•. 1~/ ev wC C' / i t e i a.? 1.- sr z"_... or/•.~; the }cca5lDn= oii :Ji11cr-1 it led to the deiiv'er, of fuod werc c.+.-aored 7., ~ l.lr'IJ2 r vJ, daC2 r F.ai ii iw+f 1 ch bciVa': iirrSi VarI aL jea wv r e m1Jat a.?4faiti va, t.: _.. .•+.•... `';~"r'Ua1~rCS. 'iii a•.J1d1.~.1.:~i 7..1.:~i7 a l.~cr/trai r•er'v'4~i1 ~''4~i1~ 5'~a~'..1m iLa..1?iL dr:~.~s w-~C.52 _.e i/i i} dc C+ f a ct I oi f 1 a i• E i: cve d t o Pa r a a 1 Zl t 1 i a i. of i: a rbv r/ d:a sU ifi d2 i w a_ te_.._ .. irt t/C =•a::fe i'rei-al"a:•ioiv. urCfercilct5. W+i..flor a::tract =vlfii=d' 1017117 0340852 EE~'~ 19?9-3251 ^ F•1achiJFi"iarl°,c:caioziCai acre2ilin.a criteria d2velGPidci"it • ro+.1et_t. r!ur- ~2_~Y ,. ~~i ~'~- -ai•- ~1 n ,a1J Ji 1 r_roiir•. 1. .~1•f .~ ir.i r ...~r ,i..2s . + - =,ai?1C~«. 1la,`fG...:-, + i~~~I_ loi~,.L /3iir •~++ `fG.,..:-, , .f J. i.• %" 1Wr CC V 1:5 t t T VF1.. } ..i l! C; Dl l i 0 5 c t i.i 1i /'1 1 be r t V • rlrfie'icari r'.ryCil:a~ ri~~ri~ is3GClatili{-i 9-i9 1700 intf+ e,^ .t. ~ 1 J.s o;lia•i f~ -_•_ ;_.~1. ....1rac1~ ~i 11 t... ?,. `/,J r C ~l V..iour i faa ;J f ;s,i iC' irSmei' i cai. 1 iC' dZ i_ o i fri>>oc1 ati 1Jii 2Y i(i v) : i0t 1-i'+.3.. > 1970, ~.~t~~ 1 -oe/~auc~ - -« ' Er,glis;-1 The de've ioi-•iiaiit of a ui{1F.:ir{Ti set of aciCii tlrll:a.i 13 a4curat+:.. i'=t i'ri;fe»ioilaa ai'= accer'-tabi2 ^1od21 screer{ir/s criteria 1.1'•1.'fuil vn anatian.:.,.&_ s~G_~~ - i_ fur Py -a- ~•~ c•trcl; ic r:edicaticrls is daacribcd. A taa;:. °a;rce corf,;=r;si,,_.' e::pei'u da'val.irt•.~j criteria that 11avc been ai i-i o'vC_. ~; tfie F'eer FStlv..2:v Cva.ifiittiCE vr t••1e Amerl::aif i-':ychlatrlc A»Oc1aLi.il:in ._.., iuF''F'ilca:ie to hCrierai ,---.aychlatria Y'ractlce. CoA1/flei4tS aii thLiaa criteria .•.a,L also SuUzf'it frt:;R, tiir cc other i-r{:,feosiunal Gi'gc:.fiS: i.t30na. Criteria raauIT'.,.k...~ madi atlOil r 2'v:.ew are Y'ras2nted for areas such as ar{t.:an:::.et' R•i='dicatiu'ii=. . a`itif==•'dc::'lOtlc 7.edica:lGrisY F1.;ed ratio cuRibli{atlGrf u'i+dli:atlOif>>' iithi=_,,,. F'aaahGS°.Irduiar,t mc'dlcat:::.i{af and tri: yi:llc ailt:. deP r ess<siit:5. 21 r•:rcr-mca._. 1017118 0332097 klEC;1979-1544;':• Ar{ia{al-huriarc correlates of narcotic der'enderice: a brief review. Stiaimely Barra; SZick, Star{ley It. Mount Sirial School of Medicine of the Clt3 Ui{iveralty of Now+:ork, :;"i"1c Gilstave L. Levy F'lact9 Ar{rier{.erg `•12: Ne;» York, NY 10029 Art;ericarl Jaurrlal of F'sychiatry 135t?3:831-3?5y 19?3. Eariguages: Er{s1 i sh A5="ei:tS :_ff aiii/•Ia2 .+=ha'rlor that are afifICl=tae ../'j iiarl:v+..1.c dC/=Cifv+_ii_2 br'iefi'3 r e'v'lewer: and c=or r21ated with the aJvariti:l+2s and uJ saa'.'ailta=.a= i:.'CJrrent f:i:7dai.tic5 of tf`'iera'ra lri huTian suL.1ect3. :}.. 1- aKLf:,tii .+.. i'hVS:.GiciA1='al aitcrat iDnS c}:Ferlnier{tally i-r0d"Ced b':i „a r f:utlaa ia've bLc_ COrif:r/°caf.Ji an i/uCia i a+JijectS9 art.rd ciasaicui laitoicii'•ora erra=ta _1 cCZr{ditiorilri=: an+JJ Oi'er aria.. beiiavlor i•1s0 have cilitical cS3Uritt. r:'arts. E.7ii-iia:• i. . is r1aCe•'_{ Uri the necesS:.ty of IrfdividUalis e•vai{Jatlrii each pers01"i to as'±1;_... tile 'rc'r'ala+i.enLa of `-i-rarR•ai=GiOiica1 f i=hySIC.Z0l1ca1 9 "iiv L{eifaVlJra1 Shanlaa. WIfeii th2S is rJcl-iep t•ile chances for ;oz_esvfl_;'l r ei•labilA tatiG-i ar c}- Ma;:iTilzed. .Tit is concluded that realization or aillmaililU7cai{ corrfCiate'3 Cf narcotic d2pzri/Jt:ri.=%C allows a beti:cr uIILJ Je_r{ _ _ _ r_• V al iJ ii id of the st rt"gt/ is Qr1J wC0l~./ fC»CQ Qf ei.1:7t l. io ;ii /C /_•-e•J .- .. +_. /li 1J'.A a 1 1 t i ts. 28 r C. fC r t:'' / 1 L t: v. 1G/7/19 0301454 ?A119?8-'1283,w~ vC-.fi7d1tZL•rlf2d r2ii.for=c•meiit based Ui1 r alnfur ciil! e3c:}i.r:.cal .atimuia±.ioi/ +: i` S- :1/ ' .- •J.. .- •_/! . ~J t 1S- 1 C l•r GJ L. •'- fG/ 1 ~L CJ •J•J t S• DerF.1 rigC' rf :'d i i iia rd j. a M;1 i r ic' r! r'ate r {V . Ml_-1J 11 1.t 11-1 i1ve}~i -:at'3Y ?.{ !L•1~ -~1/J.rCa1 aI l r~;•J.-G•-L'G~i_ i~ ~7~l"f iL!aY i.' (+ l l,iJai f G! 1(u ~. - ~ -Lt-Vi_lJ3y ' J I • I~.J c;T~•LPtc'- i V T 1 a p11':35ll. -1iQ~i=.61 r* i ~~ I+ a 977. L..1O1 i ~nrO - lC''~. -• Ef,zl1 •_ -- ~1, A brief ._ r1 t1:=ai ic'v 1+C:+ of 2::re r1/7fer{ts oii L.J/1fJ1 tiUi{e•.'{i re2:ifvrc•=i.iani, t ani:.:a {J r{ e1ect r a L a 1 _ t a Iri uI O V 1 1.J 1 1 V f t L/ G• bt' a 1 1/ a L J L' l r C vea_. a L J SL /! J 4 t 1! 1_ / r i' L} rLi.. .r Fai1ur e'= to show the 2ffet=t were a result of Rti'tlivdologlcal as==s t.a of ::i,, . F'tsea(•r=/if +=QIid2tiJ1ic•i i'cSifforcBme'C'it based on EJD has L•ei=ee daII/Grfatra:•2d 1-•'...
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.'oi'•r• r Qf;ii sc 2iiErl':i n=t..:tC+11'nm• Lea•.J~ Rra.d aff1=•_t br.31ii f'..•r.= t-.Gi. .. ... ~ ..e ri {• t;' f 1= rei icC+•+ 1 t1: i 1 r' urotr.-r r.1•i.~. tr.r_ -.._:~.s C•M Tr.- tCri is .~ if4V ~ ~ \' .J~•-1 ' • d+ Y _ .•_.•i 1t11 r.~ CI1•~1_i i1-C~' t~{vv i ~ ... _ - V? iC n w ii'sh me'm•r r oi 1C tronsi=1.fr;. :i i~•.Ji bii idirig of ._O1c.i •.ltil i ui i._ s ini.erp Math.1i7:Cr wa!".i PTvdutiCs focal •.J~aAiaa2 t:.i :S=•=_ifIC ar2cis ,-n tkl:: a.J-ea . •_. ' 1e i "' _~~ t. i~ -Cs1 'J -tJ:~4: _:1 + Ur/ •-d+, 4L,1 -• 1l'.J G.l• L'1~ Gjr/ . !' r i e~ t~ r}- 1J%~,++ U a i1 I 1~ ~.~: 1;... iLlie C~ecJrke ti-i2y ca~iit:1:'t rci'ai r t~ia i:litlal UaA2 tJ a.:rl.. _ usce=t J,iTr .'{'Vt21ii s-otii"_~"~1 :"~1: mcici'ililt•r 3. TL IiC ,Ji vC111^iirJ i1Civ1J,Js 3.]3UCiri L::y e:' si= el= i a i i'_ sus c:' Y` }. .t bie +io o +J a ai ag.: `.••y /i/ C t 1i'3 i iu c'-, r L ur'd . i t has b_.- . e Ci1=_'iivei'ad that mlci'ot{Jbuic:a are :•:~.i=tY'uoCd :+o this forG: of eY:crc:.iry o this effect .ra'~ c'v:i-li::l.r1 ti c inhibition of ci::. ~r~JJ .l di v l s ioi/ .,d il d cei i m15r a t 1:.! il Y r' iocL a s.: s it ii .; t oi'- t. ti r l,, r1 1:3 in Lkc..' de'iC'l .\Lii'mGi. . tC ~ U 1 .+G~=i ..Cs• T/1•.. IeJe .Jr{iJ J V4 `11Cr / r. :~!.. ~ iJ+ Ur I ,CsCs N.\ • ll.\ :7.al •Tr'J1._ _..i.. ... ..::i:slderobiE' e%:Ft2r:ail:eiitol Ci/aii2iig.?s in the f13:'.vTe. MH Ar{:..ial ~ Cal::iu.r,'F'HYSIQLCMY ; C=ritr.yl Nervous Sastem.'*D.:t'•C EFFECTS ~ 1-'u•Yiar{ ;*Lead F'.:isor{i;lg : Math`:;lrt{arcury Ca;rr-aur.c:_>; ~~AR1h't / i-('~ ~1',~TNrTjr V!' ..l JrT~/ LJ 1 .\ / 1 .f.~T~~ ~/1~/Tf^VTT`J Y F1L~I1LW 1 1~ 1.. • r''-.'V'1~L,li! 1 ~'~.rl.~/'f•(~'' .~ ) • V•Jf~i--V •- !• { ~r1r.! i r t L. r TJ. 1 _. P{-{ J.S. Gav'tY F'.H.S. CONTINUE F'E;It<TIt.G? '`,E•S;N1} ~ .•~~ ~. AU - mi rs6:-y tiI" rl . t.. t.. ... A Ii -- L• a L• or a tory U f F' _:, .- i• oi 1J gy anJ Ni, t.2 .. i r a: 1 ." -,F i:C'!/l• -+C1 l ~ I{-C.G r 1 1t'-f I•e• ,F:'~~~ -J-.GY 7~ n~. ,. 4 r n nnnnr~ -/ +~1 1• L• TI - Behavioral and iLi:rki?•r 1 nf o t• t E i i t 1 Oit. 91 -- TOXi IB/S8/v8..•,_'•,.i8 SO ~ - Fri'r1r{arl ~tif ' F'Ci~si=c~'i:tY v rrCL 74, ..: ~n~vi~Y i r.,..! ! in~1.-n tr,,,r• cn•. ' ~, i'~'c'ol r-rr•• ~s. LA - Erls AB - Behavioral .3ri•^'J i=syCi10r`"-'ii»lOluvl.:ai .:isaays r'-rOi/idie the mo=.t 3E'f1s1t1'vC Ind1cOt10ri Iif L•{i/eji.l.er iJ f' ! esiJliLJ i1L=•JrDta.11// t10-+ l_ deleterious rcff2Ct oic the fieT`v`O{Ja .rn":iti?/7i. The effeCts of lead i:iit the nervous 3yste(Tr are strOitgi'd swjAeativC tiiat tri1s a.-il2rit csti :'roduCe Glst•Jr'C•ar1LCs in o}i.t.eittlOfiY R.ufeOvCri there are Ci:\nIcc•! reports of such affects. The action of iEi.d is also manifest ..o ~.~ehaviur= described as 't'i'di=eraCtl'v'er: or r:•£ieCt1ol 'Tlirilma.'l brairt UaGraae.: The core ayR{ptGrt{ in both -.";.:. :OrdeTs is Prw5ab?'= ir+pairc:2;it in atteritiar{. The recer{t Diagr/ustic ar{d Stati3ti.cr:: i`;c=i1••:ai '.DSM-'lII. 3f the ATr=r icai7 F's:=.:hlatrli: A.>>uc:.atlon w:'•a5 :.Kz: t.erai Atta,;+.iari I:ef icit Disorder to r2rlacr such torr,is s.:L h`=T=c+':act1'v'1~' vy L _ri~~.. - rd1 • -1i1iic :• ,i'a1i1 . J •1aa r Ja,'RIoie• 1 ~'iiUr 5+ v{~i.~ i, /f ~F ~•ii, br2iea'vlOral to:(ii: i ty of laa 3 a{a'd eia've U'ea lna•.J~eZi..iatc i<iL {]mp1"I' te CC ssGy_ 1Jf O tterf t 1 Vri Y th1 s Lo{J1 •J 111 part C1-l. VLlrlt rLl i the var i.:rLtllit`: a i outc;,3(YIea• Recent research (-jii atterltli.)n su3gc,=t=• tiiat• It is acJmT=1e:: bCiisV:.vr cuiisistlfkg or c' il'•:.:rti•ai .=1cRieiit= or i=ol:•FlariBntai ea.=1i of 4:i-ilcil T/a'd t: in i-ar-t 'vae=2i:ii'c~r.. upon adiffc-,rei{t rE1alVri of tiia : Gr/tral nervous >`.»tc:1. I{.=±-IaVi-•ii...l a-_Sa'd5 =iiG4J1d e;:amllit2 the CVIi1p:Jr/ar{ta of attentive L•Ci:a'vliJi i.Jinli'r_r J 1/ ! 1C/_ i1 U:]• T .\+ U tests which are seil:ii':.ive to - the {';.~°r^CY'~2r1„ ~L1 tC ~~ 2CV;AITeridc•7 +,.haA P3'.dc':itiipii»1vTc3:.L.al a:iaa3a ,usIiig ,=.:i.ar1.I.1.:...,.. (c.'v?r{t'.rc'1GtCd i'V:.erlt:ol>>Y G..t'tlo'J:, .~ . more J ..!11 1 :'rr1V:J1U l+ /r1/•JJ 1_ _-LI.? ~ tJl~. W., : ai{fpi2ri:c^i{{:.Y be used .» ;rlell. These assa'as i7ra:i Fri!'v1•'..'r a li•i.:Y'L ':1_r{azii.- vie:: of altered irFforci.at.. - ~~ 1 ori i~'r oi+?as1~'ii3 in + ~.-ic: rin .' rr c; ni121: to :•o:_a11:•:c c::ld characterize the ::•c'iiavlor ai .. mr +3i r m2ni.. MH - 'ri r: 1 m•S i i tt~?i1+ ~1:1ii r i~2/ r'in2ru~_ +1.'v': :~.' C~ .~.u. _ '. r~ °I~it .r r~la0i:~cr wl+ ~/`' ~~hr~._r. It~r.;'~*~.~•I, "GI" .r1,"~J.~r~J^rnL/J1J/ ~!^v ; PIUU ~.1+C/r itlVr/i•ln•1 rt rrrr'!1.+TlV + t L•.C'll •- a,rl~1 ~l"v..al~a'.^VcJ1Ji V/~Vrr\l., L-r 1 r-/ / Gril•e: ~,1J'r ccFI.. ~ .'v1~•ir{ ~ ll..•.l+ari . r,l.l~t:.-r/~nrvrrr.cr `rr•rLrTC -'r t: ,,_. ~-uT.i ! c L.li/eCrl+ ..al a F'Ol~.„~~ 1 ~~ 1.~ i i=~•r~...r h J ~. >-`:~.IJiC^i• -~.i_. ri ~~~•ttC ' ~.-Cr`~• I"T~v 7 • tJtiRlai~- l Y • J -_vii1 ,`.i~•1 . ' t -•~•,~a I i~. nC'vi''~ .. • _• + ~ic. 1_~v . . :~'.i~".rt~1~.=•i . F. ev.. c 4+ f A:. o•J cmi;_ .J
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i-I~-c~~tmi.. f ~•~ ~' ~~.' _.it.a:. a• r /•1~vr4 ~'~r~ili~+ +,S + ~{a.!.i ~ 1 i !` v AU - tti G lsh T v . t mC r i_ i-+ OF. AD -Depar+i.'iarlt Gf F':'n'Choi03nY F.:Jtgers vi+lvei'a?t'..:r Bas+=ii a:amp:Jl! N:..w Bruri-:.:1 'C ~+~I n~•~.~•~7 ~~.s . ,.... TI - The hli--'ti::.aiu='us as a CCRiG:Ora i,arACat of n.:ur'c}..O;:i.:c alcriL;_. cr _ •r(~V/\v=•TE•• %oo/`zt'1~ c% J-~ JJ 1 L`l/ •V,~ •~• J ~'' ..1'.~'jl .Jv V • 1 °0 - TV~.i.iL • :'r"+L 49 s I~.'-~ 1 Y 1988, F''iz/~ -4^ CREF' 00' LA - ErtL- -iar ~:~=~ . - .~ 1-~F'.r..~.• ic in a a ~ tFa+ +.eSiC i-.7~3a+ ~.i+:iii to +-.~ fat' ..• + T`ic~ iliF°i+:i-~c- ir vccs~-. l. .':=' ~---J- •l --.3 ., ~-ifor(flatli~ri d2,^1' :='~~ frc~d the i-cZyi7+.:da1_ a:»~c~ticri ~;rLc 0r , a _,`_.i... C~iC:~COi tE:~: 3r++~ to redistribute it to c0~'tiCai ared .r.,uhi Cirtla: ox 2glVrls involved iii the iiodiJlatlort of ccmi 1e:. 5ciii:'v..uT+:l r=i'-iJ_':s'pCz• Several CcrF'v2rglr+g 11riCs of evidence lndi.=<+t= that th:_' HF'C arld It= C:eGllrier:31C input are an 2mpor'tar1:' rie..'•r :•blolc:3lcu.. .:a`uC+s+.r3+,c for aearrlirfg ariL'd i'.i raem'.'ii"y i-rifcessc's. I'..~stri1C+..l~+ ~~..i' of thi.: HF''.., Pr;7per7 lts affer erit i=ri:.JeCtlorisr arid lts chuliriPi'_..i(_ .',.r3rier 'ratlC+r{i 'rr C:duc2s a i=er5'.sterit Inir-alr merit in cc:ri1tL`.:= f t~ ri :' tiC+ r i. .~ I r i c e a.i t c' r a t 1+:j r i s in l e a r ri l ri a a ri d rt t- a, o i' `:~ o r i: ~~ i: u ii i! Qi~i C;_3riE•eauerice of tO::lCarit e::r-osure it is =oss1b3:o that the E~~'C .... an it.ii=Qr t +o-'rn~-t•t a. • ta fiJr rie-iiru~ -+O.. ,.'1C1 ' •~s. T i+i ~ f ._ .. :3r; v<~~~.. _-+ ~.. tL2 ~ i H•r,~(^ t~ i..:_ bcef shown to be Pr rfereritially si.JsCer-tib.'• t. to a wl+•3a varic'ty ..: ~ l•c,r;l1- insults a:riL d.seose stott's. For r;.<.i.IrlpY the Hr'r is •JrifiG•::.re•..i L.+y a I IuIli41e r 1} 1 er/ v 1 r V 1+/•ielita 1 t1Jia 1c<ir/t s ` hi7av y Ni pt6.1 7 ar/+J t{ {E. 1 a u.l11f=._3 .:;--'ri'vata•veb - 17 iilZ''+ i.aL `vi iii_ ' .('rturbatiiJi+nY rir_.•..i ~,r:.iuCt1 •'ve riruc -L- . ._ . (=:f_rebro'vaisCL:ia`•r irisuFfIC1erIC`.iY ari•."~~ r1.:.urCdi:7aer{Crati'vc d:.nea:vCla• ~. ,+ie s„scrpti'c•il:ts of this structure to a::•rcar sr-ectr:.:a o,' insults ari+..i .t'= irt'vci'v'emerit irn rllgi+e+ 1ZrvCtr cvgrlltAve F=roCec_.w_, i.tokea it an .:mpl:irtarit focal '-C+1rIt for studies of b2ha'vl.:ii a.a c::.C, ;ietlroZo :ica; tc;:i+_ity. Neurcbiological cilaraCteristiCs of the HPC that f7i1=ht maZ:.c this str i-j`tur e l.irili7l•jeiy 3iJsCei'tiblle to tv::i,: i rl stJ l++ C• r tJ.L sL •_1 s: • C J. ' - a~• Mr'Gir{ 1 r''; -CCiC•~~~' •11 V ../ 1- • C/ '~L.~'~TrAL~ 'L•f T*,~I~JGr-I' 1 a 'J1rfr~V4.OSa~''./ ~ i~.J'~cItRU,r` EFFECTf.. r'R'5YSIO:.OVY ! Humari 1 Review 7 rte'vlew/ Tutorial y::i1i=F-'orti :•.'.:,. Go'v'tf F.!-:.S. i 11 AU - Richelle M TI - CTt•te iritefratior; of behavior as a variable in r•svchopharrtiacolo5ical researc:h, SI - TQXBIPl8°/199933 SO - J F'husiol !F'aris?; VOL 60 Sur-p1 1Y 19U3+ P149-203 ;i,rc2 161) LA - Fre AB - The PZace of ariiz;aZ behavioral research iri ;'.N.S• .•,icraiacolo._:_< i_ discussed. The advarita3es of the aost refiried techr;ii_-~:.fe:, r-'reseritiy avallabief rtatiieiy operant coridltlor:iriS`i arc dsScr'1bc~r arid illustrated with e>:peririents coricernir+a iritra irit-t:.viduc;l:: iiiGer iri•=11v1+Jua: ar d interspecific hcmoSerielty of JI iJA aCt:.i:+k. :J~•Jrav;.'ori :.+ - r 2+ . t:•ori rela. 7~ :•.S-Y tct _+r+r- ~C'ti ~vse-sC +iOri~~+..er<3;.c;_ :, nt a5+:F r i i =mI syr f e rg:. sm a r1 +J i- c l. e i i t 1 a t 1 1.i r/ • The i- iJ [> > 1 b1 G. cor+ t r i bui.• .i. i: ;-f of an e::i-ei'inferital arialaals of drug atit3:+ri an %•ehav.'ur is naL Kthe XradiCti3ri of therapeutic r=ror=ert:.e' .'+:rii=ra.il.`3 fe.iLiridc•d 0• ~ ~ i''~rB= c~r+oiOSlCoi arf•~ arlt i+~.:,pOC;iori=i11.= r:.: sJniri! .+t.1t :-hc w.i ri dr r s t a r i+J 1 r4 ."~3 h f furl C t i r.i r i al l/i e 1_ ha rt 1 a 7i s. As a ri C: .: aiT+ i- 1!7 C f j:.1 ci l ,.. iiiEL E iai 1 i snl i as _ i"r° r liac r la•.""~i by bc2i+a'v 1 V i-al ti'siir iinuesY the ti' am.. , ai i3r- ..+ s-..:ra':i+Jr'a1 effects frOR• ,~ to rlori i7r:~:~.~ 2•~~.~ .,.2•~ ~ a~ ~at :~~~1j1 ~2•.3 =:. i:L ~ i1sC~J:~Sc•+ •:+iiicri sufflclerivly reflried tf•ctaods are usCdi it O2cowi::.., clear tliat the mCd1f:i=atioris of b2'iii3vlur C.:.'2r'ved under di'__.,..t car{riot bc e::plair;eu L,y resortins to abstract -sychc:osia.os. .?it+•iv1e8y sul=i as ari::lety7 o»T'2~o1`Jcri2:'.o: is: ±lvity, ct.=... =[:irr eCt dc•=r_ riptl:.:r{ aT•r=i:as1:.2a the dlffcrs_•ritial effects of d+ _.n_ C•ii 'r'a r1 ous :.+2ha''. .. or'sf which a F r1.Jr i i=atwv r1iatli:ri would tend K.. .- or{ s i J er _... _ 1./ {.J L v a.. G• r/ t Y arl +_{ i.J se 'aJ J O s1 If• p1 C 1 rl J C• r• V f aVm2 ..i eF: 1 1 e`J PiL ar/•1 O c iJ i a. a.. cO.. Pr{d rG• r f. .i ez• Be/ 1 O.' ,i V r j.J 1 1 J_ r t i 1 e c... ri V T J 1 MnUa r t . W;_• c f- . m: c '. . .: r r. Ui -: •:. y M. • n e_ = c: _ 2 n _e n i . . . 4"_,
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::1 11 iit- ~`:+-_ :;c•= :/i~• - t'--c - :~'-s2r':8tIG11 ~ Iif 1 t:=vi -''d o•' i,_ ~ic-l t _:..~, c1ve rotn G/o Au~i : ~1 r Esi'i~'i:i i ii S t., -1/= Jr, ts i c f 1, C 2 d i ii t C r v a i 071) of a i= ha." . 1 Fi i lu .n /.:, n./_. .1/ ~1 ~ii• ~.er'va1 ~ ! ~ 1fz• ~.T + i'. ~..i 1' ~ (', sec sCI la•.+ ~ ti1.r.C i:l4 l~. -r~C te /l: i1 I CUii/=Ui IC ~i ft . ~ti," •._ , in 1 =1 • _.Di`G'~_t v Fv-. .~ ~irf. . ' ~ --v _ t t o C•rJrn elrj ~lrCB'.c11 ~t . ..il~l5t ..2•~ of ~i~lio~ ~e+.~ T'alrf~ :/ ~.~ . T a/t a 1_ti1e1t/.Li i. FruCaidr =Y 'thr c•c rcct=Y trair/2d ari a tar.d2iS, FI 1 Ri:.ri RI 20 s•2.= S.=/icdoi._.. sh 1.J wCd ei1 o1.. 1 1 / i 1t/ 1 C 1 i- I r C' sr+J ri se r a t C' n /O 1/ V l i'+ sO pl i • j t J. v C l.7 C-~ C 1 C /.? 1•~~_/ r G s r a.I 1 1•J 1 1 fl. 1 1, N Os corl L i Sl •J e J 1, / 1 O t cV 1 1•..f J. t i V 1 1 G' J re1 I 1 f t} r L CmG/ 1 1i W t'> > V L• s,.'.' / Y C•.J l. 1 r the Chaiii oii~J :i J t~_ Jitlurlol 1.1 ' +'ievrie3 Gf t`e be~ia'viOral crfc'cts I:,f .~+ u tro•J ._....... ~ _ _ w could not c~C~=~s~.i:lt i~iJr tiicsB and eur lirr •.j~ota. 22 r2ficrLli.:.'3. .nvUo, abstrGct' .!L 0i! il /2V 02T9161 TA11978-15787 F'sychzPilar'macol4:iw: abSGcii217iiCal and bei.aVlGral aF-F r Gace:. . v eiderl 9 i_ C G: i:• W D'_. k=+ t r a! L i ri da F1 . rcG addrc•s s Ne4: f7rr~.iY . it-ori / >Gstrailu IS.! nCir{II~.Gi i Y 1977. 1 '';.c i ~". ~..9.0`- ~ L_ C-riauC•w' 3 : Erl Ii isri A cJ.lpre'12';sive review of the e.:1=er'irl2ntal literature ./. neurGpharnlaCGiCizoP Geha'w:.Gr al Pilar7iaCo1GgnY aild clinical is F'ri2sc'rltedr +nteridcd °Gr uSe Gf stf..lderits aiid r-rC•fe:sslGrfa3S lii Phar1^IacGiGga, F=s'-;C(liatraY and the g2ri12ral bioiOglCol an•.'~ m.=•.J.I:=al sc1anCc:=. The studies are derived frorri basic biochzmicalY 4ehavi:;ra1, Gnl:i rieilrGpt"iar{TfacGloSic data obtained frOBt animal studies of F'svchGmvto,' stim:llarfts, arftidepressarfts, arftiarfscietv r.3erit:-Y aritipsvchGtic:':_ : a3rfalleslcs, and ha1lUcSrfoS`erfs. The fir'stt sCCt•lorf covers behavior RfetifGd_: for assessirfg drug actiorf, and Pharmacolovic and bi o,: haafical methGds jr~ PsldchopharR.acGlGn'a. The second section is CiCvoted to the PharRfaci.l:•XIc biochemical basis of P'SSCho+-hart:facoloAv. The third SC::t:.orf covers drfJ ; behavior irfteractiori. Tf1e section on F''harRfaci3Zollc and biochemical basis of rsScho'rharmacG1Gvs' includes a review of the autoriOT/ic nervous s3stc'n: ~ J =.2rGt,Grii~f ~/I+J s2hc•'.'1Gr', 1ni.eraCtlGiis bat.«iC2ff F's'dChGuCii.1'vc 'ru_ _.. ::oteCeiGizmi ic'=/ o;i•:1 oBt'G:.Clrl:.ii, and t ie rilarR,oC17lO31C zmd ~.:Gti:icr.il:..:: 1 ospeC•E•s of IEcr i.Ir/a ai/J ZccSfGr'c;. 1 V!'7i 2i 027^9°i c . TAI1978-03334 Tiie fat2 f7f y2ila'v'SGr'.iSm: Skiilrfer>>OCial ieiia'viVr 1.{/. +_•fJ•J' lw b1 ki1e'r 1or 1 zI/i1? • sotsIa1 'r1ov bI h./1e v ior 1zIf. ..c.ri-.jrirfC 1 u. - C`.l L 1i. 1 / l:'\hGk. NIi i=2d,c:lGgicheSkikii riaiJk) e'3ario17 SGCIalist r:cF'iJblaC Gf Vlc'tncsiri tt~.~r~.'v3'~ 1 C•^. ~lr•.ii~~ 1.•-_•.:-~~-_.:'1i ~. J13u 111:~ '•tr~.-`r'ai s • 11G. ~: ~..i~ _p^fi 1977. v ~.~' ~~Lar,swaze_:: F::a= .ia;-, A stroiials critical review is giverf of B. F. Skinner's t`12ory of o.=eraWr behavlirr and its 3vClai 1mi=licatiCrfls. JkIriiiar'- CC}ric2pt of thzi/ c• F'iiysli::a.i sy=tE'm r c•aci.lrls to :ri-erant stimuli ur//'jCr ti/C rp1nforClng +nfiu'='"(_:._ of culture fails to take into account such complox human 'v'oZVCs as fra2G.... `+.~Igrtit'j1 c2t=. ! c•r:d 'r re1eiita aPa»IvC .TieClic3r/1: iil i?ei-iaVloraatlUll of mail. r't.-'fi? S'c-rV[c= . CiCar-ii('nZ i:llc.traC{ :»C•dIf IE di i L~ i ii~ii. ^ 027789.', Ta11978-0827, The bi=/ia'v1Gral to:;l.:itj i i' /i.Giloal^flrtic Gi:idaae-lrihlbitlrig ont1•.~~Ci=i2 nsai/W.• i/uTf i 1,S 1•C.111 i v L_ . ScCtlGrc on Cl1' n'1Cc. 1 ?.<ei~rGi={lor rra _G1U3~, :_~,~iJ ,,iJ, HTxMi'i, P(~tie':. Y MD ..i ;`w ':i: 1,,c:i '/ variCe=• lr4 i '_•S•.ar^iaCG,. ~Ggy arklj t~ t^heaGt1112raFy 1. A•71 !V,•/+Cf 1977. La,inua::es2 EmZ i t`I A review of the llteratijr e e'er taZrlirlg to the behavioral to::i,:i t'_ B1Giti:la/°Ilrie Gi:l dasc ;Mn0i .niilbl tirtg arif'i.idepressai'fts in f-reseritc d. speCif1L L•Cha''.'l:jral ciiarig2s associated with irrvri:.a:ldi i=i"Yeriel.: 1nGf railvZC'1=rGfilric crc ~• ~.. 'nCfi=s2+..-t, C)Ivl '+til i;ffor„iat•C?rf beirig r rU'vi da d Gn: .i•) tSFe aifv iiicZdcnc2 vr be/io"vioi"aZ Cliu('/.58s a:.soClatB%j with caciL drfJlY 21 ~ ,.. i / .. i~. " "- ~il... `:e;-:as."i- -.1 "1Q[~-z_ - Q f_,,=fzt_inr: a.° dosa5a ana ri::r.:ti
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. tG•'ViCr.s rCcCiit r-es'C'a1'...i1 ._n rilJitil-it •?c11e'.iu1e ai{teral.ti.l.iJ'J ..nL1tidi.i3 ww+.. .'•.d R. i. •Jcr,n=tei-i, ii. v. Cat5;iia? J. Gibborii +3n,.. E. Fariti.:',;1. Corltr'o. c t- i (~(ai'Ij,lJiat~.lJrl~ it l :..'7+ t~ LU/{ -3i~J'Cr ~~SZri+ V/Os+ 4 ~ Ie t - ` Te y v ~"f~L r•Gd{. 1 t o f e i ii=i w'2d .__ ,i~3`r'.,.i: •: Coiitr o::ed b'a ;'.t'le =t.imuiUs-rt-"irif C.} r i:e r cijritirlgericy : e. ci ., a'<i~•JJ1t1-'.:.~.' J . ... theors1f the ^iajur cor{trv:liriS variable +1 the Ceiatir._ ''.:it'=' ._. r eirlf i.1 r L t iieri t, :•Lfi2'.h rl cannot L e r1' " d{.1ceJ to lQria ={:/i4b1 riat:.:}i. A: StiRi{JiU :-reirlfor c2r and reSr=orl3e-reirifCrcer effectS. Ti:.= best dasi: r..pi:•; li:{ of available day.,a cor)t:.rtlle5 to' Ljie in tcrms of the 12ciJrit2,:t Wreircforce^.er{t.' r An a:terrsatiVe r=oricePtiori is rrovidcd b`n the cor,ci:':='t :;' •' ir{`ii.iit.or{ b5 reir{forcemerit, " t`'.•V w'~~ ich the rate t= o ~ F ,-s:or{- - ,;ir{'~ ._ iriver=ely related to the aVerage rate of reirifGrceiict?rt:'t in the Situa•tion:• Such a coriCer'rtiiJrl .s related to the acalar "2:ii='c•.:tanc'3 uccoUrit ._. :3Ut:75ifaplrig and to the delaw-redlJctiori model of coriditlorced reir{ror ti:eAie`it, SUgg2:vtir{g that a cO'iRI{:;r1 set of i=rlrlcii'les determines s2'vera: '.1.'cl ..... i.'.orid:Li.ior)ir{5 i'c'rtomeria. Ho::e'ver, the elY7i=i r icai stat1J5 of such a dc5i r'ii=;:,.: _.,; reiT;airFS uricertairi, because recerit evidence shows that schedule ii{tera=t].Oii_ ar'e teriporall'_ a=yaiFietr.c, deperdirig r-rir.{arily :,r{ the co; ,ita :ri1 reirifc•i'cE"ferit that follow a schedule ::or>iporierit. 1119 r ef l 22;'7'9 / 68-09986 Ne{Jro:eptic5 and ,'7perartt behavior: The ar{hedoriia hvrootilesis. Gli=e, Row A. Cor{cordia U, Ctr for Research ori Itrvm Deeer:der{ce, Mor{treal r Cari;:1z> Behavioral 8 Brain Scierces, 1982 Mar Vol 5(1) 39-87 ISSN: 0140525X Journal Ar{nouncesierit: 6805 Lar{g{.cage: ENGLISH Document Type: JOURNAL ARTICLE', REVIEW Neuroleptic drumJ disrupt the learr{irig and Performar{ce of orera;,t ha_ j!:._. Siiotiv5ted .•'= a variety oF i-oair.i'.+e reirlforcers9 even at d+:.we:= tha:: ;.a.=;c':._: spare the ab7.:ity of the animal to initiate roSr i:3ridinf. NauT''r_r:yr-tiac 8i.:. can irt=c:ir respor{diflg that is rlorTialia sustained by eriYirori7.'~-~rity.. :ti......!_. and aa=o:.c•ted e::F='ectarlcies in tile abserice of the Pr3Ri.:ry r2irifirrcerY the'J blunt t.;e aup^,oric effect of acrcrhetar.iir{e in h{,maris. These „osa, __. •-5t,re.,~+ t`.-c~+ ~i2Urv -.,le~=L ~,. i.-; - s2ieCt1`iei ,':i 3y ~. teriija+ ~.: the (Ti ti:~rfo ~,,. _ ~!_.~ v ,~ i"y .,iVo .c. ~,_. ... ~'' .. , ^e1r{c,- _ ......a; that is _, .tical for :oal`directed Lef'4a•vi..7r, ric7r?ioilj induced .: iu i i d e ri vi r c• ri i, e i{ t a i st amiJ i i a ri d r i orma 1 iy a i: comr" a rl 1 C d L1:w the e:; r= +_' r.. :•? r. : e ... . T ieasure. Because these drugS are used to tr euot SL'hizo:'-hr2ri3 and C<II ' ~ { _ .. ,_ ... F'arE:.irtSor)ic:n:ik2 side effe+_ts, this action ii:.t iTiiriicir±ii:iri= fGr h.,. ..•r :•at(lo1C•gy and for motivational r-roci?5':re5. 26 i=e2r co?.merita!`i:=s a'id kh, ~ r al~.,~i~i, .~ ra'":.>i-:!iiSE erG' arperidE'd• (5 'r- ref ) ...y /7/1`• •. 67-00482 The temporal reaulvtiori,of behavior: 1. FI acneduIe: Control v -'}'~•S:i-iJ,+._ - _t.. ,~c~~` cri~~ ~ relative ~ ., ~~ +,irit.. L G.'.J'C'{Jr/•C•, i 1e,, -.1 U Lies'2, Lab =fti PaycholC3=i3.+c E:.per2,iieritaiel I'3i1miL.I:i7 e::erci;E_,. A'~/ {r{ee .s'3Li i•~ . 1980 •- -Vt1`L -~ A1'?1~-C~~ ' V1 -4/.1 CJ4'v ~r~./.~) c V15V ~/L•f /•1 . /t^/\ ~..l1 •, -•J~ '1'~'~ f 4rr~C~'+ n .yt.'l ~' •~^~fy 1~J~r•.~ ~e n 00035033 Journal Ar,rioUricer.ierit: 6701 `arl5~.~ . _.-vr.re• ~ • cr2rici7 .L•v ~.cu(i.C'rlt , .r-2• v,.,~c • .r!n{v!,.t,,A.. , ~ iyR~'r~i-r7 . ~:Ev!!~.E4.' TdTi~.~. c•ci.^t I r 2`...e:ia characteristics of rI schedule control in ariimal=7 pesa'Jri1w patterning .scolil:,p vs Lreair:.-ar{d-runi, 3.ritarraaro„si= Se:ec'.,ion, ari& number llf responses :i Cr ir{terVa:l and r-or si.ssivr.J+ iri : 1 data about Fi and relative time are cori5:.:jered. G'J3tr:lr{f~r~._7,2i.w • -C.-..f iifid .,reakpoint, OF'2rarlt and Sar{erai actiV:typ and Perfor,i{artce indices ..; d'1s~ L'~'~3L ~ • iri i'Gi't .:, sC''vG'r a i 5~ { f 3i'otiiC' sL 3 G re O^IO iy.iL''.f • {.: ia.r ir 1 J. ns1 yi. PiT.!' Qi._ ,,. herie ra liz'_ t i LJi! of ti ie i'esi= L•ri're , 'J%e 1 a''j' to re i ri forca merit . 5. t!i? ."aii4Fvri=iri, eVeriv7 ari•J irlhab'.tlCiri-Via[:~arl:. • Tt is 1.7, gJL ~•~ t/~. /t.~t 1_•L ~.--is. .. 1 ~ .. .. . iri the Fi _= iedUie .S T,oriitor ' e~~ by t,1Q ri:ir{forc.Ifig 2ve"{t azt1na v.., _- s'_nChrorFlzc`'i' a/,d 2r1duc:rrln a balance between .Irclliyit.^..•rs .Tll:{_ilaef:LSi;is ._, ___... cit the be:.r{ri...riS (:•f the interval and 'Jt'=eraRt ra:r•orFs2 C'.:SJt:ut. lQ .,M 221-+ .1 i v Try`i r:'7F2
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l'c'var tCVS•rit of I" iir_:i{uaLy ;=•i?r'r'.i....esr 5.uiaLi F!'s+.n•.'{iatiorl ifiilsi itc•... ~ Fc OC. G d Ci ; yv CH. f ' 11 T I ~ ._ AiJ,, er..~~• e.cF ~~ - t 1 o+~ ui/at•v.,..'.L j t C iiai d7 ir i U1 t.f i et[' Lr 81 - TD`:.E:IB,'8O.~C,5'71~ " • ±lri ~ r_•ii •-arr•• ~ ~• • i .in~r_. c. T~r 9, iT. inn,~-?, ~ n;,„!n5 ~ _q^+ (R~.r,r. . ~- ~•„r.: ~. - 1~la! LA - EriE~ 11D - Ti ie ef f el.. ts V f O1/aba.111 c ste rlJ 1 J use oi/ a tl / i C ti c i Crf V r fllOnt_ e th%e ad'ver :': effects assvClatel with the usC of JiIU..•aliai_ stero.~,.d_L are r C v 1 e i. ed. At 1 a bU j i c .J t er iJ 1•J J 1 i cr e Ose Prote1 1 i 7 u1/ t`'.. 1!asi 3 +~• skele tai mu'aCiea and r eVe• rae catabolic er oi.CsSa=a. I:.=.: rIJae s~ ::hc'se :'rop:_•r tiem9 sor•le athletes use anabolic sti.'Tvids in u{'i u~'i.•a':.~emr=t to ..mi ro've tliei r athletic 'rerfGrRianCe. Ha.w2L'l:ry s:'.'.iuie::~_ ir{~.Ili:at2 t•~i~?•t 1~~Lreosea Iri {~.i„~j4li~ f{~jj.j and atr.?rt :l•ii fJi.ir 1;.• cir3ab1}I1C aterol+:.i ad6.irilatrat:.on are obaer'1cv oriZw ..a• athi:'t.:.-s ..h:J J C• 2 r e o' ~~ y ..1 re w C i:D i7 t" t r alri C ti O i id whfJ C lJ rl t 1 r/ fJ ... 1e ri terf a i'r' e t ra i r i iA.::. VI h1 1 e ~~i a 1 ri t Cf 1 rl 1/ in / 1 il1 i-pr V t C 1 r/ Y 1 1 1si/-- L O jor 1'e J 1 e ts. Adw e r::. ._ 1_ ff e L ts G t t r ibfJ t e V t aJ ..'7 1 1 a bo j 1 c 5 t e r o.I d use r•'J L L•J r f 1' afJ C r 1 t i':. . ...~ eriofJa ad'ver aC effects include her-aa...:.c arid eT•dzi:rinc_ C{uSfurlCtiortf cardiovascular artd behavioral :=ha:.ges also c>rC' rE'rar..e0. r..e0. . -.~u•e G~ ~. ~.•eT'~~e 2ffe=+ ~.5 osaiiciaa VC1•J ., Wla. ..~~ ~+•_i~ +~.._c cruo + ..•i2 a•JV use WtiieSe o'aerits are irre'verSibZe) Fcrt1CiJlar i3 in woiT:2ri. The fJ.'.e of csrlaCli3liC a.i'.ero1d5 to ii.=ro've athletic PerforAiance iia$ bC•[Um4_ PreV'alerit. HoweVeri tiip rePor t+e+JJ benefit:i are t.:iT.i'ere•.Ji ,_._ r4umErous ad'r't'r=•e r:'zCtians• MH - Pt :fre15joT./IiRUJ EFFECTS ; r,,i A_abol~ ~ 1':. - Ct2rci~.~.~I•~ ~~ 'MItlTll^~ ~.., ~ Tr•AT.Tni: .a DCSF,CE/*ADVE;:SE EFFECTS/PHARMACOLOGY ; Cordiova:sc:Jlar Di=ea_•cs.' CHEMICALLY INDUCED / Endocrine i isea e: s/('•'{ 1,C ~• ~ / 1 ~1 1• a.. MI(^AI`y Ti'T~t'V!+ ~ (r E A.• re male i HlJR.ari i Li':e r D.i se0'se5/ CHEM.'. C.A.LIY TNI%vCrD ; Mai:-` fffJac ie=/C HY..CiIOLVVY % R2'v iei•i ; Rewlew, i Tt_iti'Z r 1<:•./ ; Ci -."i=r(T.oa• ~v~~i ---c,-c_. ~_.. r .r~l. DRUG EFFECTS Y*S;-ort s ; ueigrit Liftir,A -, ,, AU - Lerirrier B y LahrecofJe C AD ' Zeritr tJQi der Pharr.Fakoii7niey J.W. r.7Gt:.tlle Llni'ver Sit:ati i' r arii:.furt ,ii Mains F.F:.C. TI - Chroriophar„iacclo» and otiroriotheropEut.i[s: definitiorfs ord [oTi:er t=_•. SI - TQXSIR /83/J53CiIC 60 - C''iroriobio; Irity VOL 4y IaS 3i• 1987r P3.9 _Ia7 =c; LZ, LA - Eri:E-~ AB - Most knoc:ledAe of medications has beeri deriveu froa• siri3.Le - 4r1•~ tYH RiultiFle-dose iri'veStigatiorc5 iri which Pha3`,ToCor'.irisytic al/lJ i=heriomeiia have b"t"'c'ri e'vaiwatav fCii.T.Gw1ni l:i00r :JafJailyT daytl'ie •"+JrUg aJC1IrilatratiGri. Ci'iTG'1c: hi•r7io.:.oZ.a::1C atUv3.....; i ri•vL• i iv i i ig ti fe e'v a i.Jati or1 of such f Fi•{C'{itiiil:r[ii of ter e i•r h of a'c'wc i sl.. different c11ck-hofsr treO+ V11C ^1/+ Vs ~J ~ur1r 1:r V/ t Y +=t'• do, a//•.J ' 1/1s1 fV '+'t:i~ 1:: ~il-~ r-'G'wer."i ..i~ ~ • .a.L a. v -i 7 _v:~i_al ~ r~~l'~t~t. iufi1: r~r1la:Cs:: _%J._~~ ~+t _ .~l ~_ •C~i ..h t~:.• t•iVse Vf 21 hr- Y C.•- r i Pr ii f o f_i rl diy a f f e[t the {<. 1 ne t 3 1: a a i i d e f f i cts nf :' a r i Du_ SR'c'di(: at i 1r is. Cever ai new C vri[ eT-t : have a r1 seri ba3e•.Ji ar i f i i r di.•....._ rro1:i _hrl:iriUpiia''ii.al.G2 ugaC irfveatlgi.7tiorisl . :.:•if as Citrorie=thc's'1 ;.nd Chrorfergy. These i•re :.jef3ried arid d:sa:fJ:a'_t:: L.C.'ia(.~ ~ i/ :rf ~J . - iri; i ia~..!st rO t 1•ve e.i/7~.r .l [s. t1 {ilvjl• r g1JO.i. ~.1f a_ f{ r[•11aJr hv.'7 i•'mGci_• 1 V a 1L re 7eO rL `I j, to L/. V l.. a. ` rOn,J tshaI ae•Jt1 L i(ltc'r'v'er(ti+:+ria. Cilr'ori4GtherapefJt1[n 1S tiiEoi=t1miz3tlirri of dTa..' effe_ts ae'id/or 7..LiiiR.izat.2on of to::iC-.to Gy tiT.1r1g r•fzdj1:a}..i`. ... with re :ar'd tto blQioa:.+=a1 rilythms. Cifr:rri.itheri,r-eutlCi.a takes '.i)t:_ J aL i[f ~J Tf t ~~ r e fJ i C t a i_+ lC a~.i i f i r1 i 7 t r a t.a V ri t.a Z/ i ' dopIC rf J C i f t var 1 a V i on .. ,. L•ile i-hc:r ma[oklriCtl.=_ i:f drUSs aa weii [•a the stisi ei-t.lbillt'_ •.' tar3;-t i.i==u=s due to t2Rir=i:,r.ui orwnlzuti(3ri uf r'-h'»:.s[:ie'iizv.i r riJ Le 3 7eA aI 1d f ui 1ct J or1 s 1J f t t Ie L• o•Jy C• 3 \ 1 r 1_ p i i O i i O ri •J L• V ~t. ; r i Iythmj. Ti ic' ur i=au._: y iy J 1 w 1 V ed ari d an.s a's• di•:y iy theiJi' ii:i i lina.: tTestment =a_.iE'dfJic•1 for the =iii:i[ai fR•i'"n•:i.a.?iT•a=rit of n.=+[tu7:.W'. ._ ._ t imar u ha[h .3 r=• IJ A?:us3'L" fJ i r) t/ fii_ ut_ Y re/' r- f2 0ent 3 t t= i - 1s.r : _1..: ~ 4 Arf3.Tic.. i ci v=8ji$0 r1h=t:~iL . Di IJ! AdA•.iiil5ti 3t1aJrf SChe~..'~i-ic . .r.~•r.., qTR.:T T !'2?; 9 P•^ SACF'/jF'HAr;MAf'.^•KTNF'TT:"S ; Human *Re_r_!_.'.diC.. .,_~
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~~ n_ • ` .~.1 . F'i iGT~`!ai=:iilia~~ , ~.C'v'i C`•i / 1'.e~ii e4i/ H~ u•.~je.iTri~ r = i v it r N.. c i r " iJt .._ . v o '. . rn> T•Tl a~~~C r'~'.'~i~~T'"'i~v~ .~'rr...r~1.~~ ~.iJ th a .. _,~ 1f ~~ AU - Nishi '\ f K1ndfi T ! Nnrobawas.i3. r/ Ah - hepO rt iCl i l• iJf 4tC'.J r.}.l Jgn/ Jtsfl tCfflJO V11.i'4 er , t':J JLi iV J l Uf Madi c.'a n.'..' : TC1h. 1: av, .ioFcfl. c~if.. TI - CA mouse model of N-mevht.3l-4 f'ife ioi ii0Qr.J ~'te..ai'•'a•J -iU:~.~~'1•.~.1.~'. .:' • effect Cf fii_iii2i-1.'iei-hrlfic' j..ai rii1,...,.. - :iflduccd .--aii-.1fiSOfiinTi• dC' st r ucv i V t 1 J ^.n.7 ..~ri - TD1lBIB/n-~f'v^.c .J:1c.~ ~ ~ SO - ?'do To 5hifi4:.e.:, :'0L 39. 130 i ; 1937, ^C"r•._. ?i {REr': !I.'L Fi ' v p ir /~~r r /14r ~,T6r I. '_t9:~ r• _ _.L..ti~~ i"1 \ 1 1 1 r r i-ePora..•ed to ca:1°-•c• ci-irofiic F'.:.rkIfi.i.JiilsAi in h;.imaii=i , ISAIti:',tsr c.i)i 1 ' la_v-~':.fi.~ r' • _ ttr iatal . .~ ~wir . Tci s+i'fl in mice. e n.-•./., ~.ic ai i - i.ru_..:l ,Cif fa ;~idif{e eF.. '. T{vdei_ thUS Pr'i:.disced cioseiy re52/i•ble F`arr.if.soi/rs •.'J~i:"•ni3-•e. TiicTr::' :ii e5 ho4:e'Jer ! t4:.:r 17ia.1Gr difflc'r ei{cea. Tilc• one i a:i•1= .of :.cw_: ..C.3S=+ieS aiiv te,e Gi..:rei" 1s tiiat i.Gre/=1frc: hrifi.= a"3F•eT, '.s ra.:ati.Ll... :1eii PreSe('`.''c-•d in tffe C/ode2+ So the acute •:iilA/al i7,u%fci is .:•ci i.., coiivl'•_iere•.J~ a fll-jrroatrlatai dorali.lfie d::fJL3C'fiCSi 71odci. We hc.`di_ f' 1 Ld•J L Cd a fi V 1.+ hC r r/r V Jei L• y O t, di fi :g \ {-,elfll~ ,Jl T;. A}_a: \:ivrL`c~•t/i'31-1~'etil'.:~1i~'2'L•1'uZr~i/t..?l.~f{z~:.J..a o /ur'rr•`'~ • i to M~.Tr+ / ..,._. W.1 OtC r1 O.1 is knL.• +.. 1 1 t V r 1' o•.J V L e sG• l e L t i V L dC• st riJ t. 1i 1 V/ f \.l 1 iiorer'-i'1a: itrinE termiiiai in the i:efitr.': f,er'.'o{.JS su'i.i=Si as well 6_ :.fi the i-a?r 1+=}"`iCr'a+ u.3th filjfeplii2irhrii/2 a`.istcTr aif"•_i •."rsiJe'-aRraiee '3yst::~-ir ui'e Se•vereiy dee-i e»r•.'~i in this if1odc 3r and tiia:: fufictioiiai role vi' fioreriirephrifie SySte6i was If{veStl3ateu b3 coRlfrarlfig two models. °G male E57 blackk mice weighif{g 20 -2` fraa.s were used. MF'TC' :Alt;rich) was dissolved in sterile dJStiZlPd water with 5% ethafiol solution. E:rperia{ental aricrr.ls wcre divided into t`+oce 3roU'r'a. 1) control croUp; in this gr oiJr'= aillTiaZS recelSied vehlcZ::::i alone. ii) MPTP crotsp; in this froup, mice received d4•iIj i.r. doses of MF•TF' 30 r•alE;I for consecutive 10 davs, thus total dooc_ of FfF'TF' was 300 ^i5:f.n. iii) MF'TF' S DSP4 3roupy in this mrou, animals received d<.li`.i i•F'. do5e5 of MF'TF' 30 {TiAi%.5 for coi{G. ci.it2vE•' iv Oa!.-.s aiiJ at the last +.'~.al:> of i.F'Tr' ifiv=ctlvie tie_._ 1''cc2iv'ed i•.J `'`=F'i 50 ,r "'~l,''b: .':-: = i.i-.. 7 t.:r .J I a ra:d'3 u1 t,ar t~1= : -' ° ..._ _ i fi je ct 1 oi i of Mr' T F' bat i{ t r 'G'' .,- t e`.'JJ a f!•.~J c.+ fr trv i lie i 1. e rec C 1'i e v a., n ..iitraper:.t[:,fieGl injection of .. _DOr'A 1200 Ai ;rrk! a ar u'fat1= L-om,.v... ~ i`1i`4='i_ :~ ~. .:i C: 1 r •:J e c a r b.! ?:ai c+ s2 ^ 13 , 1t~.gr ai~lti ~. ~ i~"/ ie Q1 f ii"/ i1a • 'J .~, . `J"`.'~ Ui i - t~.•r_... Ai'"titsp= were 1i1:"c'at:.aate•".Jd by 4:Sif.' bL'-iia'v'1:'arols Clioci/efiiial h.~ ~ ` , i_•t V r i v Vi'e_•LC•fiL'C~ :iet: fo~J• {, ~ 1st~if i~.~orIC~:3L ^iiL e st~ju ies /~i._ Lr'ii~f ~"i r_. {iiBthoL re4•c•u:'c'd se'ver'c' reiY)Uct:.ofl of fil.Jr'ontr .iatal du=-<3R1:.fie ie: NF'iF ;r'L--'aai.ed micC''• M'C'-:i..riimbiic aftd tiiCDai.oitI.:ar , dJ _^rai•l/^ie a`.Sav.L..L. _. 2eAieC i'ciavi':ely ri'irsrr'ved+ Ti'.er e wz5 f.o ai-Far2fl:r .:.huf. :e1 li'i locus coe riJ.eu: ii.J •''er' i f}e='ii r l fiie aaata/3i • .T. i4 .ir'TF• d hCr' I +• r=aAi,... _, C4iLe marked r'?du.=a.iofi of fivreplfiei-fir:.fie tcrilflflai fiu.:+r e:>a=eiicc u_. LJ C i i as fi 1gi-:J 1 t T 1 si.r ai •:J or- a ir I 1 i i e SyS t e/i/ L/ as o,_` se r'•d ed. i' fY e_' Tr 1 i:: a= .i. +_ .•` i c' Z'j sl c :i f ie or c• :' i f i r:- r'- il r i ii c' a fi d diZ p" a u. i fi e ::• !d HP',... C ._ zf{ f i r Cal a:: d i 1 i siV of i'_! lJ r 2::r 1_ G nCe sV ti LJ 1 es• i• e/ 1 O v 1or p+ st{J •J 1 C J N% C i- e l7 f/ O A. '3 ._ 1.~•. 'J L• _. ACltouie;: locomotor al=i..lvlty Tieter• Marked lifci'ea:3e of iaf.i.i°,z:,._. CiLt1'':1S was t}l• `~-~~•C,~1'l~\•IJ t in / vra/ r TF' t^eat^•'C•~.{ ,.j mice GI _nnr•~., i.., ~ MO~~ c• 1 aa 1i-/ ~ (..1• V/ 1' 1 vl.lai.if{1strC1•1•J.i.'.A1•.JTrf'.i15..T T,tVI'tCaTED AT 400 WV~',D:-:' ' N Animal , a U •Cfi:~~il-c nI• v Mrln!^CI ~OC •J~f 7 • ./=v7rifiar~rMi- rTi•f~T.:r,._1LIri'i .. __ hlllfie~r!/[ ri'~H Ir.:.J r r.../{a.~~.l-v -i Hv '..'-t~-~~ar`~ca ~ i t ~ ~'a/.~•'`1AC:^tO`'v 7 r_:~c.~fi• -- rrlc"'r- ~t'~vvloi=or'1"~/ ,.?~ ...1 ~Ja ~.i"vl„ ~•r,._ ~• ...F1 ErTV ? i iG 1 e ! M1+: e Y M1l: G 1 i i{br:_ _i Cc7I•, s ,~ Tri:TjRL.aT.r/ n1.~rr*``H/ nt`' .J/ !^.v G•ae'r•..!~ 'lfiaofi r/ ..•1:~."o."e, J ^`.STii- .ti! r i~•yr_ ..,TiL• T 1.a}vi- ~. r, ~ ~ 1 t...V 7?er.L,~ iE1M[CTnHT.{•T/'K!r,IVr_Tn.~r.rnTt..~~...l.~r•J ., ~~.i•:.. . *~r/.T..f.•Ylti. ~:i• r ~ 1 a ... i CL.i vl /r ,~ 1... al . /. u. , i- r.. i-1 i ic'.:. . Ot''V i t' .Y . i 4 C r.• t:_I 1 C. } F G vi C W
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~ :~iiiril'ei.uli.nC =~ Fvvd-n/C•tIVotev UrYer aiit C•Lho'v1nrY tJ':.liy c.:tl'vits) 4t'17.1-s:n::e cv(lGitiJrilria in term: of rei="~'rit eViv.?ricie. A.=ceptc,r.cc• g[-'iierc•ilzatiOris related to the dr iJg's action sirf such i.:+ehci'vl•= i= r cn.:1/ that one aiso aci'c'i-t ,)UT,erOt.Js L+jJollflcotivri: Gr i'S'i1ta+.ioria lri term_ dr uA-dOSe fc•cl..ZT'sY s Vario'b1cS / and tr,.sk chcir :i-'..eri s'•t'..: ="s. HowL'v'C r s de5y i'ab: lst'_ - F = ut: h Zerie rai iztttl4.Ir. _ :. S =•'t.• r e s_cd. (64 ref.) '•1'.:~/-r ,ric ~i ! ~ ,•~ a 43'Q^T~~•' ..r ... F:ehav,cral F-horr,actlloo_ ari : to;..colo:E3. weiSS9 Be r r{ar7? Lotle5f Victor V r :1. fl'Gc1le=ter ! School of Medicine Z D.?ritZStr~j ."irtrt:JaZ Review of r'ilc-'•r'macOl,•~3a/ 1i69q 9Y 297-326. ..,t ~ , -~' l.tii~ric•. /-Iriri_ ~~~.~~it:t'';'~iLit; .• ._.,. LarigUc•ge: ENGLISH The btJZk vf recent wt7rk Cri the rieUrGche7i:acciZ cDrr elates of b2:'ia'v..or ,.._ been d1 reCte d toward the adrerie r3iC SUbStrate : of behavior. This st_,_+ ['C'v:e..tis the C'cl'Zav:Or'01 correlates of catc'ci1C1<:aT.lr{e c',jL,p1ptltit d1e to _, dS'"u35 as re=_•erp:riet tetra:er{azlriev r-thIOrOaAiirhetaiSilricY 5•`'.'dri7:;ytr"y='i'ap:,..+Y 9 a:='(la''.etiiyl'"metc'vyrJslrte/• ar1Yj ,:.iF'ha-Riett'1?::-r's['a-tyri•S:.rte in '.'cr...-._,..s icibv^rat_Ir'_ ariliTiois. Also discussed are the results of mafi3 s{,.u:,~io5 •.'~;2<_;..,n, with the IriteractlOriS of (1) reSer}F'irie with a'ir-1i2t3^•in= d1^'ddro;:s=hensic5lanlneY tetra:Zeria:irieY 1ui:arraa+irie, har,aolIrle? ...''..' u'Hii=ileta„irfe Ciltil air'=ha-^;eth'_1-para-tarOS:rILy chZarrroa:;'•7irie7 dIiiwar:=.:wphL1,.. .7.alariliteF desf':et.ao12i'+:.iraRclriei and (3) ali=iia'Riethvi-irara-t'.:rO51r{c with ,,.] lYiOriOaCii l'e C::lY7ase 1niilDitOr 5• Ar: e::terfSlVe r C~.VIe'r1 of i=ei„G::1r{e 1.:_ t~, 6:c.gne=1u1+, ,^,ad:'D.':l de? once atti'2Lltite+J1 to have RNA i'Gl„iie:'ase ana me;.t -3timulatz ..s 1=ror-'ertizsp disclosed that it has rio berief~cial effect a„ _iY_,;:,,,_•, IE'orr,irin7 Lut mav I/;ipr0've Perfcrriartce Ori tasks reat.Jirir4a 31crt::c•:.., Flria:l'3ytile r ecog'Yatiori of an ev01'vlr7g new d:scSi'IirieY be/iaV141 s., tG;:IcQZc.':v? is noted a.•'id t`le tGDC2c2ts of such a3erit5 a3 trlei+:o•',:•ea:•ila:a:r... tatraeth'» 1eads h'sdrozirief =henifirazirc?q c:•rbcr/ cit:;ri.:,::ide9 ar.d .: cirlt:.crii:ii:.rie.c,terase i'ev:..c1deS is r3.ScuSsev. 22/7/16 41-1233:' ESTABLISHING FUNCTIONAL SPEECH IN ECHOLALIC CHILDREN. RISLEYY TODD; GOLFY MONTROSE U. KANSAS BEHAVIOUR RESEARCH + THEE:AF'Y>• 1967 r 5(2) y 73-88. .i0i.:rrla. Arir:CUriceiRerit: 4100 Lariguage: ENGLISH SUMMARIZES RESEARCH IN THE DEVELOPMENT OF SPEECH IN ECHOLALIC C1-lILDPFi!- THC c'E:~',r~EL,iVI~1.'Cr ~" ^"En ON OF'E1. ~'fH*,!T Etri-I.atVtTC~t-MJL~IFI' ~ATIn'~ V '~ATIn, '~ Tcrl-t'~•'Tn,~•J~L.•~. ,_.,. / L J L v t~ .F•L L L'•IyJ L• 1 L. . 1 .L f V 1 ~. 1_• r I 1+ L l~ ._• • r r C;S: (1) SHAPING AND IMITATION TRAINING FOR THE DEVELOL'MENT OF SF'EF- .CRt Yr i ,. FAL+Ic1 IN ~;~ ~•` T).t OF , A<.1C_;!+ ~ ~ fILT ~ A/I L FALTI 'II>I <G O,., ItT n Itc.^•TL-~AI Q5r' ~"E,D/ TO - TF:i,,_' ,, r n>,YeIr_•r ~-`•n -•t~, ~-r• 1T~T,YdY~' ,~1C yL.1.~ / Tt` ~ SPEECH FROM IMTTATTIIE r-}'~Tr~ntL. TO CO'+lTRvL BY A-•~•5Jr'FiTATE STI,'~f:.~~~'` a a ~ uL // V , , 1 1 .r _ .. ~ ~,i:.' TTi.i IE-OJ,T F:t1 ~~S RL.r < r~~}I~fLEITI~n'/}~.^ ,:, AND (~ 1~ ~) E.t`T.:~ .?<If'TIOPd AND , :, IAt/~CF.•r'~~/IL.1< .~ ~~"~Ca!T cn~,. ' .~:;i~- REUCCTTO'I OF I~I:~F'F'E;C1F'F.II~TE BEHAVIOR T~`! ' V"O?1J"A'CTTO'r WITH THE L~.FF-..~iE'1i.+,•... J Y.. J / 1 V< / 1 + r'\CL.T 1/'•Ci.i='t.'T OF AC'F'~~nC+RIAT` RcCC+nNCCC 1 1~.1yTry /~~•.C Tra~+nMC~tf'~TTL•1c L WITT' Y.'~.CnV IC~'1._•6.11L. ~< V/ / V f / L~l1 V V t V .~ V \ V 1< V J L•~ 1- 1 Y+••~ +/"{ L. INr'•iF'F'Ft'.^.F'RIATE BEHr;VIOR. `•77!% -+/~ i-• ._ L I 1 1 4J"- 084 7 :: CCcEfTC V f i c L T L. 1 1 1... 1 ~ 1• 1 .:ETY P SEYMUUF NATIONAL .T.'d :T NctVtcincrTC/ ~•~rcc L / V,d '_. 1/._ V 1_ J 1 ' ~~ 1~r. , Vt1T1 LGa %l V•J L- a ri j tJ G=. C` • ENG REPORTS -~ n>~ v CGE.':I.'. aM.T..'iE3 ON CF'ERANT E'~•u"C'{tV'In''•• L. Y/ ,.~ i t. S. 7 Sr"f MS.., i".< f F Ft CL1E E,iL. L. ^`Y~\ ' c•y ..:F, . 1_ . OF MENTAL HEALTH y BETHESDA 9M:t . RESEARCH PROGRAM SULLETINc 1967 r/ L{= IT/ t! 1 t • 4A V v' ^ L.1,J1T1,J!y DEW' S cTu,nIE^. i T-IE E:FEG ,.. .• TS r. OPERANT BEi/e^I'a.Jt . COMPLEX BEHAVIOR AND I'<TEF:ACTI^-•,'i= r F'EE;<' REhCHE£'. ~ ARE DESL:F: I F ELi v AND I T 13 SHOWN TO BE EFFECTIVE IN ~=,,Tnf't>trT>r AN y ~ U1>1 <DEil.~ Y llLi 1L.~ ,l F' . L+ E WS. r 5(1)f .'S-4t0.. OF v Itr1RIOtutS BIrli3~'•,iYT . ._. •..~ C H' M..,'%~C':.. _ >./ TS ~ rn;~tCt ttrcn T.-l~ ,T r_• ~ L.r~ r~• ._.,yt-.. Tun' ,r ~~VL~~..• ;~,: T~E {tr/V OF U11 1J 1~,~•a {~~Lc e~ ;~1YT.~•~V^>'T'~,-:: ~ +.^ 1Ti..IL• / Vr ,'::: r.''~.nuI'^nT. In, '.~ OF BEHAVIOR t,,n"c t.,i.t. vl L. OF THE Q'Su/< < "~r t~i. HAS ..
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1 ~.~•Tftkrr. r~~ ~.~~1^. ~.rT t'llr../\•tl i'~C n•~ •~~lnlltt'r.r• r_:f 1 T~:~Vf-_• ~•~ ~:~~•u AN FiF•F'SE.IAGH;r WE 1 CT..LJ / JrEY SC f~ F/i~In~ {~l[v~,L~a•.~E r r....,t'..r, -,..f~Ti f~ y E`TC Tr< , ~ ~T~vv. tf~lz'nC,HAi:,l~~•v.Mn(,.^.r!I`nG ~ e Y Txt GEf t AND B~'HI.VJ.• ~ItTn~f.:•~i/L f.Itl.nn~fl'~i~nlL.~•~~.:,i , u>, ~EFeAL. ~~tl• i~irV:.~ ..., 'A `TICUL t^ C1V1F;,, tlEY L~/ 1IT1 ~ A / ~•fsTEr, tl OF l /_r CYG~Crl-,~~Mrir</,• t P~.,: ;~F:. WE FOLLOW I THT.J .,„r•_J THE L.,~/ ~~l l_{~~L L~Tc-: WITHIN TBIG AREA AS THEY RELATE TO THE ~, etr'ItE•nEf•el• ,IT/Vr~l.rf1 ~ f.. OF n,...: r.I,~t ~!r L•~nr,]•TJ ~ „r _ _•.~.-,,,;;.L ~. f f_ t.. v . - r n~r!{~T 1t''% '~•-~ F:cHr;ru,F. ' u,F.' , r f t .. ILy17r 11 0528304 ALCOHOL SELF-ADMINISTRATION BY EXPERIMENTAL ANIMALS FiCf'.>r'/n-iRCA AI:Vf,NCEc: ALCOHOL AND DRUG F'F;Gf,LEMS> VOL. 8 MCTt^JP~1'i-fP IZ ~~ n L 1 L~• Y'f • 11T1v1• OF l 1.( 1I~ ANr ~r•ti" 1nOr-L 1TJr, MN ItR I~}'it\1C`C vOTA, ?< fTariil Uv I. ~ F• f [~CG`C T.1Cl.v. t YV(~r,`#\~ • (I1 \ iJ4 r~ Tr•',Jpp~~• 0 V .. ,J~nt{J ~ 0 LCLfA~JM , C•RL,_•,J 1[` 1 /. , I Aftf .J ~ ^ ~T ,.J 45, ~ 7f]q1J'1 al'1't . 'V -".~Y. ac V ~c•1 - LC:c-{Z•JOlGs• Er\GLTaS!-i • £! o1 L`J i..e`i L Tar e• lZ. • V rJ K nU~;ING THE ~ LAST ^~'IvIF'F:'nrf,L. YEARS A ?~Ji~r~ a• f 1 J L. 1 / E ..ni F C Etv IEw:r.! Di- ri f'NIMAL. J f L•y 1 CT~1T.T`S ._ . - :,h!`f~.`OHOL T ..Iifi, ~.T~r,k'E l LJ:r,~L. BEEN L•n11C DCL"1' F' LLLT,~1 C•1-iEr l~ (^~..TCC~fn.n VY 19791 1980; MEISGHY 1977, ;72:•• . MELLO, 1976; MYERSi 19?3; FOH04cL.CK/ 1981) Ar~I: ~1 ttr_n~.° ~ ,.inntir_ .~ ON . i 'L. v, 193i~: cr".•L.f~„~ ~~ THE '= J_L•WEB, :~ OF. JV /!f'l•H _TV t4TrTC,Jr••Y i.~rvJ UFHL. L_ ~ a1 V.. l a 1. L L. J ' LY 1 ~'F~0L. `'rrr£~I~C'•' 01 ~ S^TL.~'~iTTF'Tr~v MrrTI1 t~`V•.ni 1 t.,~/~'t.r. r ri`L_/~•.. L• 1 L. .+/V6_ ,.. •1F•C•C~rir•CL~ (EIC,. .I4;;~J:. ~ f `^n>f r'T AL. ' ., i ~980r i~tCf^~! ~CL.a/, L. r'1.f. 1 ['T n •. 7 ~ 1 Tf-!y~ ti..~L i TC r,C1,.1TC~; ~-/; ~f,L. ~1 ~.~ ~.nn Vi~:~ ~ir.1Tu.~tL r~TtfVra'.TCv ~ nc ~. r1fL^nl1/lnlL. T>/TAIw-\C L. ARE ntZ.nC AI>I <AL1 I~L' f 1\ V1/ 1Y`r~l rc•n~( A J/~ l l y l,. \ {~ v: y :... r+r.EV f^Tr'T/V ^ r_•r•c•rJ.•:Er.•T1v1, Il/<11/1"I V/ J V V l {r VV 1/Y f . ALCOHOL INTAKE IS VIEWED AS OPERANT $EHA'JIOiY THAT I^: r u.n 1 ~"S ..= ~IrtIOr. \ .~ f`,.~i NT C. C=.: . L•TS ~.<JL.~«•Ar,.~~ BY T ~ f jfiat+CCnllE/tt"•C^. CC~~SEC~UE~ICES THAT RESULT ULT IN INCREASES IN IA T'~Irf•.f•!.,;rr•"C Tt £i, .Vf, ,.:.: Ef~nriertTn; ~ ..r,r.. Tc~f.''•slL-n i'~~4 E"jj~V f F^~tiGE4J~• V f l L/l L• F^~i EXA.''0•F'LEr FOOD-DEPRIVED :'EI: r.ATS CAN :r TRAINED T,'~ ~' ~:~:' ,. LL~!v;eFi Tf ~ sc'~rfcn1'l c'ri,'-cecc Re<,3'1u'1L.T TA! hetTIVtCrfZ.Y nr A F'i•''0~~ PEl_t 'L.ET. L! *tiDLi. f ~-~`..,.._:.,:_~. A Fi L. 1 r_. L. L. L. V J L J L. 1 L~ ~ a L- 1 1J f ~/ L T•: f:... . O;T ^ HC rn•.1I~ 6C'IL.I4CT F'iVl~'~~lr'TInitS AS ~' A F•rtrTi Ir ttr ~inT'~i/~^~,\"1..••'r'~•\' ~ J Q{ talJf' f T L. f V L. L. ! 1 1 V V V i 1~ l L. !- Y i •-/ !'1 t.,,T' • . T il'._, BEHAVIOR OF PRESSING THE LEVER IS AN INSTANCE OF CF•E:ANT BEHAVIOR. ia ;C i'2F5. ) i ...J /:4 050251`-, - PSYCHIATRIC F'RESENTATiO; S OF '~E£~IGr, 1 nlL. TLLNLc,.zJ• V nr. rO>~OTnVIc'.1 r<,!G;, lt.r L•AJ'Jr'£•~t ~ •. t ~• . , ~• . £•~t, ~ •. ~t, . EDITED BY R.C.::. HF1LL. '`E1rV ,J !f •~r,~/;K!I SIc• / >" lElr~Iv 1 1.I J~ ,.L ..1. lr 1.1J1\.! '-n1'•{'L. Aa1~L• , '- ,.~..,..TL.~~'f[ITr'rT`' ~~~ ,L,'nna~n1 1920. ,{ SGHUF•EF,°T t i . CLEVELAND METROPOLITAN GENERAL HOSF•ITA[t CLE'.CLANI:, OHIO ~~.<L. ~`n~'ictJT ~ArTRY . (•tt•C_.! ` ..~ Is'"p: f^r>fCf';,~ ~ n~l i'~c•1^•rITri~ ~t t Yn VRh:i '1+• i5•T ~1 JUL :^S- 016G- 8 S ti 3 . E~''1':vIL.Tr1J 'J Lcns:.icl2sI~i.. icc{Jmeili• Top: `. BOOK RE;1IEv: T '~V ~50/t.~ ., a rr•T .lriT•r L~ f_.}~TV T)r'C~' CCrTTt.iftrSY fT .~,~°,~ 1 J ~~'T .. `'V'~lSTL ~~L.~r/ l•cJ ' sr Lv l .. iiEA1 F'~J•lr1~l-:,~T '~ . rL~rl ~ Tr : f f..- L. .r 1_ ,.. a {~ ;Tt''.'\.. .:. SYNDROMES AND THEIR MEDICAL CAUSES; NEXT, PSYCHIATRIC f:YMf'Tt11'.~^~ AS F'RESENTE D BY VARIOUS MEDICAL DISEASE SYSTEMS SUCH AS ENDOCRINE D'SEASE ;:'.r' HEMATOLOGICAL DISORDERS; AND FINALLY, THE BEHAYIOF:AL TOXICITY OF VASIUi_!'', P1EDICATIONS, PSYCHIATRIC AND NOttF',^~,YCH:ATFiIC. bIELL DOCUMENTED CHAF'TEF;::; DISCUSS THE BROAD VARIETY OF PSYCHIATRIC SYMPTOMS AS CAUSATIVE FACTORS !''! PHYSICAL DISO4L'E4;, OF WHICH HEALTH WORKERS SHOULD BE AWARE. (0 ref_:.` 10:?: 13 0500870 F Y,.H~ f fATRTG / C•F:EQ VE l~TTrt>i OF ILLNESS: • S/1t'SA1 ~"Yf,.LJI.. f^ r1TCfT1•r['r,r^ ~t~~ /Tr,/,,,lt C' 3~~1•y,.1.LC~T11•yT,. .f~L..~VTn.,fC•of, ~• ~..J,~41...„_ EDITED BY I;.C.W• Hi;LL. N.Y•, S P MEDICAL AND SGIrNTIFI;', 1`'SQ. TCF'Et'Ef M. WRIGHT STATE UNIVERSITY SCHOOL OF MEDICINE +-`?1 .r_•n~`'TCML`~rf' ~~rn~/`,j i-~S'iGiiITY/ 1 ~ ,J 1~ 1 I ,T~.Y (~'1C1W 1 Ynt-tit 1••i ,jJ-3'Y ; ~1'. i •.J ~ t i L. f l f V '/ .~ M/rf/ ?3:: :Cv:-r.e 02,. -S'•41. f._ GnlfJ 0 3 C 7 • EN.J I- y J H L• ~~L~-iilE._. t f n ` T,if'L':• /\ a • ~.'`~'~•`' F:EV ItTE•M f.r ~Tr• A'•~r r~T~,•4•c nc THE .cIT1 t~r_r,,i~nc~:~' r•CYCHrcne I~nr1TTC. OR .cna.cnTOr_~C•aruTr., L c{cL!a,~f,r-/T .~ ,J 1 y \ V OF , L_ t- l,..l, ~ e• ,J 1 L JL• 1 a ~..31•. Jv1/ V f 4,_ . V 1 f 1 V MODEL. AS r'SY;=l-! I r+TF:.: STS AND WHAT M0^rL t L• L. SHALL E:ASEIi ii EFt ARE INCF:EASIr.5LY CALLING FOR A fi`"TtVlr.,.l TO u~L.~r,'r~z1':_.- rl / 1 i 4/'1 V . L s V., l.... cnrZ r.~C~•nn.fTTTn>•1 nr_• ~,~JYr; 1~T~T1SnY n r/r_ A Mf- 1 Slrn~r_~nvTiH . .+,LTv, f ~ 1tVfc-JnT'-..n~,t ~ f.~ . 1 vl 1`.J,3/ty 1.av,t ~. 1 ~ yr~ / 1 .~ cr,L•T iGfI..IL Tf ,~C ~~,~ .,. . ..~ I/L•~rtL~tL OF I~TSr~f1`,J~< <'r"lrlfr...1L, LC riTi•'n1'TrI~7 Y. f1T4LtL. IT BE THE t T{~rnr/r., L'~...,''''1..rr:T~-l.;~~. L• 1 L_ ~. J, L• L U /,_ y l- . 1 L. .-, i /. .1 L• _• 1 L' 2 :_. ;..eVT'~. i T ,J /f 1 1 ry WE E3F'CUSE Rr••r,1v1CTTnrfTCTTrv ^ Mn~i!cL /~~.~., F•nnMnTC^J ~ IT) .~n-Cr~r-. V L :t•vl.+NtLIc~ J/M 1/ _ ~ .• THE L~L,JI 4 a• J,: [ 1 J J // V L- / L• ~ V/. V / L J L• n• 1Y £• . LTf•iGS/ 1 MOL• Trr•f A rlr• F.rjf11'.f1UCCr, 6Y Et Y I Crtr, AND nT1..~C.r,,n /iY^ 1.:/~1J i0,.r" 701!` ~T .1~i-1, IL 1_~ .) / trl_.JL.L• L• Ll• 111f L.,,•_~r MAUNLY ON THE IS i•F.`G°?1^(1-IT _fP a . rcl >~r_-r;•nr/fL. r 3•YJrTtc'_r'.f..I l ,.. fltll• V V/<r. "' Ar'/ ~'SOr•H? / `~/ '~ Ev IIE~ ~'`^nE ~L.~IrIOL.I"TI"'1.,~,„ VI_ L... f : +.1Ei NL r' 1 Y:NV SvC53G J TS THAT: OLiISEASE CAN Br V.iZriLi ,,... P.-b1_it ItPC '1C ONT'rT= 01T "AY .C":.ll II+! ONE 0.: MANY AYCTEMS. 7T 1~~ - ~_
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,'; _ ..nicu.. .. mr .... _ _ ".i.,.._.,_ ..oister) „ob2T"t L. wcha'raoral rharRra.=s?a.Jo'_i .2__._r- '.'irsir..a C;_,.,•,zr,::2alth 'J. Medical C c.,". of '1irl:a.'.- ;tiatioi;=i I(;s}..ituto :.n Dr..:m Abuse: Rescarch MG(ii:iar.u}=ii Serie=! 17.16 No ..1'i~n`•.~ .•e 1 i.~••i L_-,vt.~~-~.'• MT.C•f-r.•. '.f.~....ur.., 'nf.'-~ ~ I v^~.wt• f17i.1f",..r~nr ~• ..iofJr (ic•i 7406 L-• -s-:~~.~ -,r?e. ~.,.~ ~ • • `.~'rr:!LIr~i i itoc}~are,ii „ ~ T'~pe. . . Ju Ps iU!F:/~ RL> ~RL ~ ~. TT!.`t_f' ~,; ~;, .,., :_ D.sousse= the '~r ~I~.' f ~i?a! ~ ~+ b2-io'Ji:rr3 ir3i sti.{+JIL3 with .-'i~2riC'~C.I+ .n* ., cp. o +}-ie .o= - j v_cL _O•c. r.nr,.. nr a> >1 .T;i i ur1 iur tv aT+T'ietc/.2(7as 1 i i:7 ster eotyped b2iia-..oT' ai,d to i.Zar•.`".•itC:i'c'3ti? ; in i't : (rrodui=t:isif oF •ata:..n c. ... v(itl"o(i:;leta c'ff2Cts. Ho:veV2ri =`..r.F' also 3pi-e3rs t::o have a U(il:+u2 =?c•=n v 1 s!Ji.+_iete t. r'e ef` C;_ t s. Re sea rcli w i tii {Tiv'iika'.r s si-,ows ti'fc.+ t .1 ~ Seif-adfi..i(i:ater +.JiL`I:•en of r'vP :3iSFfii:lerit2y illah a:r to C+:u_.= 7,.?rr.-..~ f.~'.•ei /a'J i oro.: eff et: t a• `•vP has a l a{.i L+ci=( i found to Pr'.-1 ditii: e m.:: de a t toler,_ r..- _ dcvelor=(:c(it7 a(;iJJ a •.~i2r'•'2ii7eii:=e e=CierloRierior{ ca(1 al2 T-rv:i•1Ci=•-~i in Tri7(;k2.d= L..,iK; relative 2asC. (PswcINF[i Database .r,or''yri5ht 1987 Aiiie(:caii F's' ~ '~cri1J:i-•oa_..... i~i/ =,=.(if i c. T-.t..,= r Es=r':e•.'~~) 221 , . 4 7^- l~07tL•Ci L v V v • t t }E'fJr.6iLy. •E`iL 1Ov1i- ~ t'C~i~I i. r ~ '-^. '~7i~c'^~j to JsSC'ss ~' V// 'e L / ~fiG~.LV n+-_ _ i.J1 ~ L/ 1 `-CJiiii=c -.'i_ - •..+i•GJ i.ii i . i •. .... iee. .iJ'1_ ___tem. Ti i-_•or il :i'1sif rl. j lwi~..,r-1L-~. l i.i' r ~•1 1/ 1 icou . , r ~ r r L. National Inst of E;iviro;ir.ie(,ta1 Health Scier.cesi Lob of Behavioral ;. Neilrologicai To;:ico:o ;'S: Research TriarigZfi' F'2,rkf NC Annual Review of F'harmaColoau 8 To;:icologwv 1984 Vol 21 425-453 CODE.{`ir `/ T1TI•T 1 T ~.C JCJ/.A/• • 03M642 Jourrial Aririouriceliierit. 7204 Lari3uase: ENGLISH Docuzie(it Ty-re: JOURNAL ARTICLE; REVIEW Revicws the literature to develop a rationale for thC iJ1e arid seleCt:1:J;; of behavioral tests to assess a3erits for F'oterctial rieurotcXlcitv. E>ca.;p:C'::. of the si3ris and =jmptor,is.reporteci in humaris exroscd to rieuroto;:i(i's such ..._y soiverttsy leadr and methylR;er=!Jrn ._.re Treserited and ci_•/;irare•-`. to tFio_.. rei=orLe•=1 in arli,7.a.s 'c•'::i=os2•=7 chrorl:.caily to the soT;c ril:ilri;Jto:..='d(;ts. r~.- C.}.ass:ficatlu(I of behavioral test ~ „ sv Crl t2'.3 for ,~^i2CtiOr;;r and _t3+cn,s f..~r /IeiJrL!_ •LCil _OViViOl t'-'sti(ig are o'Jti1/ ieJ• Met_~~:r to Li r_C '.1vtJ ~ . /~V ~ .i, ; V 1- ~ V '~~_ ~Vi r i 3 a .... L.:amiried in t'c•, ,i,a of tests of {iiotor c3ri•."` si:ri:a":•j f!Jrictao(iY reast: +.. to or .~,.... a,'';=fu=a: 1 .!c•a("riir;s and Gia(,iol"m9 a(id (iatilrallj oi_"cl1ri'Irfi i..l.:ila•r'.:irr =. G', v;=+.,.. ,n... lnherert ., behavioral test'sl such un ador'totio(i to the effect_ ot' :~ti:+ato(Il:fc ~•(i+1 1~lii.~ti:J(1 1: 1 ,~ f t`iC f:31_tors contri~+~i~tirig tc a "e;.s':.Ura,~l u^ . _.;.: - •f oi~t rii~L~ ~`t.,i ICff•'E'i_ ~ 1e+~ =S and "t i't'~_ _tc; ~'`e'- rfGt'l, ~ s ore da'sCi1sa.:^•~. (127 r /a1^' -t~ ~ /l',_~i/1~/C ~ . ~i ':_i98'T+0 C:( i~i,rG.r~ :(i~i,rG . i,rG: . .+~' C:2~-;0'.'1~ ~`-;0''1~~` .:'~ i(itra~.e(ios5 (I:cot..(fie iii.JGL~• 4j .V(1J 1, 1 .[y,L.. , _-;',. , .. vi{i /:fai _ e :.;i)Idt•er^lr .jte:en Fi. , Sreol,.ia(ir F:oger D. i Risrterv t"1.:.r_'U= E.; ,,`I'i(f.:i5'' , _! , .J' ' aLf~. E. . .t.+i/oi ~ r~ i `rr• ''i.t.-~ ~ ~•1 i ti'1 of l:~LUi~~i7 i`~~.~ +~ ~.'a• ~. Iri~ -L of ' •.'1f1s2 nt? ~ _+~iC+.1Ivr; RF.~c'ar crr i . . iC+.I v r ;,, Eci:timl.irrC S MD L'ii:ici{'c'T;l aLi. ry d Befea'Jlo r 7 1983 Dcc Vol 19(6) i v'. i-i .J.. •. f.~.r~C ~.,n~l',=~UFlv .._..•1.. ._.., If T~-~`}'+• .n~Ca1•~r~C. ~is . 1 C~:• ~ ....»r (iai Ai;i;vw(rc_r.;ciit. i'il).Ci . t-s(is._.rAe. EN: r_.I:~=H i.c_:oum2rit Far-e: JOURNAL ARTIC:t-E= in t;r .s (3: c( 9 .- r e3e(i+ _°d at a a`.dR.i oa iv{i. on riicot:.i.e zs a (': .nf 4 r.=c t ,.; ii u,d c• (, _. (r d _ n.i ma l ,1 _ 3 t t he 7 0t t•1 A: , ; r i.: cs . Ml= e t . , , m J ± t, ._ A;L ar . o._ , F` =r = cf 3 o. o=, i_ a1 As"_ ol : at iorl he i•-~'r in i W u 13 hi e iit o(f i Dv a r. i1 !... .. u=t i 7Sti, i3!1+..h=r = review studies that dc'tiYo(iatruted that b4=ilavior can be co(i tro...;?", .... rii._ a ti (ie ) e!` ` s(ijc'._ t.a_l.ins ..(i di Ff c' r ei; t wa;A s LC'J C r r r'C'. si (i'.. •....,• Lan_._ _ ~. . sau.r r=a i.._.:i.G'3s a.,& .=ol2es we1'e ^caiiita..(ie•."~i wel: .?.:ov:= :3ai2(is"?u•1stitJt..._,, lC'JCl_ b= ls r_ _ _ cu1LJ _i ,__ lJ/ 1 % • _4 A1 •1:1/~ '~/J ~, nVj. -t/I •Y•.j) i..i, { ~- -•J! er {-''a '~ ~jJi- ~'J I,i +~i-i'C'-'~J _ J • i_ L .' C` . , i t_ ._ _ .. , r . T'es+°ti:.ir ISC B Ci(f+jer F. 3 mf,/k ike'3 3 _r,.: =rwle-. :der t 17iui(Ita1rfc2u :•d injections 1f .-.0-30v Rialli: 2; rhe ,iZlf`i25: roti5 of r8:roiidir,v ws= r2 7ruinta:iied r_ _ er+_o, _ ' - :i ''' u;lder 2r.d-ordar sn:ses' 5-
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+ - - - , of +•r,_ rr~.:rl a - -a r ' },,irr! ~ - _ -e3:~.: :~.-;:....:e.a•~ rr,~- .z". r!J'"f'~. •C'_11 rl _f'G•G -r •, L••.j ! _C1~ _Gi r ,i ~J _r •fs1~ _ _V~.C/ - -iG =.?. T'h, 1.1 C::t.•iri': _ ^.i_C_ 11 ± '~ tr/s_ - ~C'.J iJsF _ t,.. .. ,.. l•1I•? _ i'Cn~-• . ! I~ t!-- - O-//iJ Y•I .'C•t7I'sI127-Cs of -•~ 3•J ~ti_r/ Tr _ 1 ]+L •If•J-:~ ? •sL - v ~ . ~r f1C•J i/ r.:.i nc'I.IrDvo::icit'r.. St.udie5 of the i-arkirlsorlia 1lik+2 to;:ic.i t_ Caw:_:•:: G i?'> w,r~~~~ l-:1 -+2f'.ratla•.~.rrOF-':drl•.f3. ~ • -^.2 -=f-r'-'i`i2i1'~ .'~.Y'z VY.~ vi/e llulP1'r1o.•, r ,u b':r-rrvdl1C'f: of _yntiie=is of illicit i:ii-.:a:.a3) e::eTri"lif'~ t ic be._.:: ,3pplic,~t:;:rri of cur rert a,ethad_ i,i r{curctz;,:.r;.Iogs. It has c•oa., ~ ... -~i J w-i , ~ O s. t hC IC .i i- ie asi v ri t.i f Mr' TP t o.. i t: Y±:. r iC i[ v i r C:] .t.• 6tri lS1Ei't c+'bQi ism of MPTP to the Pr'U?:ima1 tviliccin~t ..-met'-.,~,,A.-4-f'1 It• _i 1s.l , _i iiJ11 lS.iJ1~{ / i'a 1hr(-r T rryI •~1•.~ ,~ OLi r.C• 1r^ 1+ 41J . / r _ - _L'_V1-` L 1 1 ~ .-r'1 ; .1've Li+ 1.r.jP•.. C.i'.Jr'=aliil rie ii eurvils• T i-se di s:_ o'v ery of 6L.•i ii'•.J.iifn S:s te s of Mr'r' 7" :n i, i.f 1C_•::UeilS has clarified hOw dOi-aRline t:{eiJrGi{a are dcsai.rG'3ed:+ tLtrC'b'..: i=ctJ_•:ri.:=i nels roa i3= :LOi = igr,= . Thi= i i.[au3t r at2s two It.e-':; :=vn.:ept_„ f3y r at I tr it• bi C!cQi /'v ers1:ar i of crJm:roui i•:y a t,.7 FrGi:1 ii3 Z tiJ:::.;: ai f t s .,. ... :=iftc'ii i1(1QrE'•"_J.y aii•.'~~ SeCGiidi these events are unlir:.le.l.y to bc: de t e c t a b.i a i_iy .n i i ''r' i t r o .a t udz e a t'i i a t f ocus :d i i a few Lio.l he/ir i... a.ry. C'ndpC•ifits. Aitofi"ic•r l.Jservl e'•;aTi'rZe bJaS t lot of eistirr0:3.'•.n .FD=.~ R2i1 NLl. 3)y Iii wili l=i-i :i:Jmer:ri.JS Zif v'Itrr,:r a vudiea :ai.7lJC-•tav th&: }1iiS l '•nU.•t Ci7i Gr1 iGr CJas a ~'Ctci{tia1 ~ rlei.~ro~ .v' r;ii=ari...+ ~.v _.'r;ii=ari...,-+. / /~Gi.. .2'veiY 1 ~.•- r.. : -_ ;,~c: :: ._. _. ~ FiJ•~ ::. : 1 1 U wn t U be a i{ a r t:. fa ct ir f t i i C a til Z i 1 ty Q f ;- i-{ is L ii 1 v r to r isrux:. C•iORieRibrciries at iligh :aii vitro CQriLentr"at:l..anss aii•.'~+ this idea ...__' sUppCrted b'= negat:.'v'e data frGri .:ri:rth .r'.•ChaVlorfil aiir c.l.l'i:ai:i•:l =• tlJ+.3i el. Ti{Ua i the Pje+i.hora Cif i-0s5:.::•IP iiinltcul.ur ..3'td C/i.7ch2iri i_•::' 1. targets in the central nervous 535te1a { r acEFtGr39 S"t`•'carls.:i RleaSerigczr eVeiitSf tr aefSTiitter -IZiOduZatOr a::C•i+i./ic=5i:>> -tur age __• _ reieaaeY m2iibraile 4T/ai.ntc'riaiiCc•I etc.) iYr1eC"'il.lJe t~"-C 1 .Ir. I.cali '~sLirL•~_i /I '•_"'levei+J ing a Si-1g.l.e test or a.i".•attery of leUr G.:i"•eRriCai or . .p `ii_C" t~-ili: .-i_.~-1.. tcSts l t4at :ilal 1. 7- L•.2 a~i L 1i2 t_ ~ usi rc ai"i f(:ir r'c-IridClRf:_ or efF1C:.eilt1y. Use :r in vi -+!.,r 1. 1 f trG Tici•11.~~5 is . ~ir•.2+'_; " d"Ctei+.t both false Fositi'ves and nLSiuti've5• While the a'vail.itii.r.F-; of tilei7r ej.iCai L r r iieiivmeflJZOgicai dava Prl:i`:i deS tilc Gr:>+it a+,."i•1_ ti:r tile o`i-r'iii=ation of aVoiiaC•ie b117Ciic•c:+.lca1 a i+f mUiC;=uii,T :•eCflriimUe=? Predict:0iis of iiellrvti:i::iCits best can .=Cr7•e fr:::,-i/ theoretical cOR!/=...rili:/ii of the structure of Suapc•C+:.• Cz',p.Juird- i-i'-:i=Ci•l/i2 =•l~e•:iCi•l/i2 =•l~e•:i+•l/i '2=•l~e•:i :.c ~- [ ;.+ea) wi /1 t1.. 1 /4.ilia . . ~, ... taL~i~i s.'/il t ~.:~1rl. ~2+ s. SZ~.cs li/ ,. .l/i: rx'c.Cfi.T.~~C T TC..•~r,fL.T~•.•tL.1}lvrCrT"i AT 400 ~ 1 r.Tlt.1„ ,,_•~ .n~ti.•; Mf-{ - r, ~rii-iel r . -„a.'io!.' r EFFECTS " Cerltra.. 1 td,-•rvc~~ ~-•rvc~~~ ~: . ~, _4. r•=:~I•RL~v 3 em I i scaB„ ... *sr..•.)E1~".iC.rn1L`Y iNDUCEDi PS,iCi'FOLUVY Y Hj.lmaii Y i_:•wiew Y Ra'v].c.ws . T~•J.+.-l.• -l / v ~.aC•+ 17 AU TI SI °~ ~ LA AB M ll Se t tC WF COA:i=lei:it'_ of rielJrOtD:::.co1Gvicai aa5255/T:ento TJXBIB/88,•'1:27?;:, '? euroto:;ico1 Terato:r VOL 9r ISS 5:• 193?, P411-6 :zEC: 53) E c-i g One of the central obJectlOt•i5 to rGl.it.ifiE' behavioral a•as+..:.ri:~; concerns tEie difficulty iri iic;..erF'retiicS` beha'v'.:.ral effpt t5. Thi::; r-'eper discusses t,-{e ass•essc;er{t of rieurotc;.+ c h•3-ari u-•i:ro dit,., fro/r/ L• V th c1J //v"L'• r+ 1. io// O 1 t V.=i ici t'3 'J t•J J i C.9 •J i/•J L• [..•• 1 1 Uvi i.i rLs i _ tw'J iti_. r .Lt• •J ~jC'scr 1be s vi/e brt•O•Jth O1 1•J J 1_ V/// p1!C x er, pr 4: ~'.• :7 1 o1/ l I f ri C•J i L! +i.r L• r._r. 1.. aff2Ct= f the inference of nc•ur'Gtu::icity f r(+R/ bei,avii]r al and v'.:hcr uataP aiid the .::iidats an•:: iilteri-r'ietat..oii of G2ha'vi.lrai Cff'c•_+.... T i l'c.•' basic oue= •+.. i s= ii a a_ k'C• !J C• a r egi.l a at ory Pa ti t i i./ l-i r e v i c• w c: r.- .._iC 1.1d2• • .A. Ca.r or{ effect be idciltlfia•7Y .2) Coil v/lrC effc',=t 5,.. considered to b._ a fui{ctiot"i :.}f c'-`;:puaurel l.a) cail the affect "_ . .. .vii~ •E~i'c. tCi d~c C: ~~1 r.. - .. _ • ;_Ui'i~ 1'?Ct effc'Ct ari thc ri!"i V+juS saa+i,em9 oiid ~. _ - r + L~ r..G~ C~~:i^i u to u ~C ai i a•JV u,v.1i o.cCLl •..v'i~i . _ c~''L :~ :.~C~r~Q:.j :~C ~ ~, , .-a Ai' e' i' u.•:_ hc.:. J ui~l•~ ;ji- v.. vri'_ f'_+ r ami= rvv1na the .y n;.C rr- r Cta..i i i i ty of C•..i i rei-i t a, s;v.,. r r_.: stra+l.CN1Cs are y2scr-ibed. These it'iCat.ide ia:: r:iVaT•r'nts i_sli,_: O Cf di V:. oi is +.. C! "c' i, isv .i rl g 3 vudi CsY e:: r I:. C I t V C 3 ti i isJ an•. of geiier"ic tes:iiis rec<uirerd2r/+i.s for si=ea:if.iC Cri.=zliCe:l -..o.?s_._> Pf ri i I:ia7 Hll-ii ' (^ 3'av ~Ci~i I~i3Caaca.:W •1•. s/Gr1tT P+n/1Y I>,tPriut f-•,..C..i~. ~sra ?/ ~'' tCivili-j~= JI•` •errl.r...r~•~/.. r•f._•r_. Pi'iYJ i DPhiTHi Lvu`i Y Re-•.' i C w 1 i'.e'v i C•:.ti r Tutor Z.' l J it i ak ra.. aF..nr.. . Ui(ZtCd •tivzv=_ _ ir'iroenreist:sal C'rvt+ic'•Ctivii Ar7rriCy .UrriteG c.-,tc-i:n_. r'"--' --..4 n,• J., ,. ,~ ct r-+ . r.n . 1!r, + r_• a
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or i d L e i 1 Ca '.' .1. _, ,_ n1? ays1_ ur{ V C• 1 t 1 1 rlC'` O t'C • 1 Z r/ g r C ri .J l t'3 C..~3 i I/J .a t i V 1 1s in a '~ ~asc .' t mErital rqtarda;tiCri .•:ith a h:=t.:rr y of rei-eated f1r2aCf.t..ris. T`ee tr-icc:tr.::_..•,. J, siaais ,3r e •a2r..:c~J frl'jm the funCtlGriol C?ha'v':.u:"oi ar/d COg.iltl'v'e siiioiy=.i= ,_,+ tiie i-riCic° :it{.iotioi{y ti{e veveiCi=7eritai ariaZ`.::]Ia IriC:i..idire:a utt:.t•.1•.Jics ,•.., attriautiori_y the /;iuti.•ational crid s;•lf-coritr;:l aralysis a,i, the of social Curtditlur{a. rire-::ettarl3 is defined aa /ir/ i7:-.''ra'it behavior ;Ji•::s_ ; ClsCrl^ilrlatlve sti.T.ui::_ C:C:ritrGl. An lridl•vl dual tr eatiAer.t F r:rlr'aT• i?' 2 v<:;":: to the different tiier'a: eut2C tCiset5 is eataill:she`.S• The i-rOCecdlri.=.s ,..,.. i jBaCribEd ~• •_ 'ti/v -r_ ~ '~ t~_ lt ati . qr~7r.~~.'.rt : . 04006078 80117073 Behavioral t:C:;.icit'3 of r'-syLiiatro=ic dr:.iz:1. V. A t t t r 1 L V i' rl V 1 t Nerv i{'T•p i i?ii ~ 1 ~~~ ~ ~ 'c`rlF .. 1 •iS Mar i~~! i~g (3) F~ir 's~! T i~- .r~•' .rle r' .."~.•;• •.._J.~~.~• .J V i.{ rriai Vo•Jt • J/'l1C• Lar isuales : ENSL I S.' Tfie F-reserift r"t.%lew OF F'sS't='hi1RIt7tG'r reaFt7r+se t+•~ i-aych.:.t:'Gi-:..: a'vhstor;C+:: .... restricted to riOr i'ial subjects crld 7e3Cr^:.bes r.::SFOriaes to the ..ri:.:•i..l i _taridc•r"d dosB Gf : syCilOtrOF.ic siJb5tarlCes in c.:i/:il'.lur/ u:31 . on...... F' 1 a C e o o- C o ri t r u i l c' i7 stu•.1~ i 2s w i i 1.: h F t' rm.'. tt c• d a t a t 1 ata Csi :3 r i o iysa. s 0. treatrierit sroup differeric2s were considered for the s..r/aiar s. lt w~:: revealed that Vi rtiJolly all F53Cht7tr0p:ac 7oC•+aturiCZs hu'vc de,.ractirig effects. The nature of the effects vrrled aCmc'{.•iiiot aCCvr ^J..:._. G..; +~i 1e Li laC~ - - of -iJ»^Cst2•.t ti IOt t/ 1J•s /•d i . •1iii.J ,~ r~.Irif/1 •U -.+'1/J/ 1 ._ • i i.~:> >Oe ~ .1~ . l• ~P 7rV-: ~. T i+ 1. .1C C 4.J i1 ic 1•' 1 fil.•.._ iaiFlicatiari5 which could 1rifZLi.^.tlce the choice of RieCii,caai:,ri. 9/7/25 03574588 78208588 Arci7ial-huRiari correlates of narcotic deperiderice: a brief review. S t 1 1!I i/t t" l B; V l 1 L k .Cd L` Am „ F'sychiatry jul 1978, 135 (7) P321-5, I3SN 0002-953X Journal Ccde: 3VG Lariluame1: ENGLISH Kil . Cwled=.`C i~f Gplot,E' aCtluri in iobCru~•Gry oril7i<31s Cori L2 Of grcot v.~.aac dc'.'elCr''irl : a rational C l1rilCal aF'F'rOach t i7 the tr:ea tTierit of rio r,=4 ,....~. aep$rider1i_e• 1 L'`yii.}i{J l•~sic•7A l OiU ltC1at11LJrts e~ , rrV -•J••J1~ _C•J ~• ~ L.• i~~~Ii~•21 11 U17.fl 1:' y rl i• /,. 1J t.i. ... .~ have beeri Cfarif i rmeti :.rl aul;iarl suGjeCt'ny and classical l3Gor atOrS effects , :: O ri ~'~J 1 t I=' r i i r i : ar1 d or'= E' r o r7 t .:• C i i a v i G r a 1so i i.: v e C.la :. ri 1 C a l C3ori t.= r= ar:: l ~:eai:.CotiC{ i C•f arlil°,•-i-i7tili.orf CCrrElotB3 of r/dr CUt1C j:-r'2rid?riCc` oi i3w. Cetter uri0er=taridlrig of the atrerigti/a :`•rid weaknesses of c:::. :t_i• ther aF=evtic CiodalitiEo. 9/7/2S 03177255 7 70,725S SchrC d{Jle iri dUced b"c•iia'v ior : a review of i ts A..~i1erui its? di?t2 r(L:ar„arits ,.. ~... i"hG rii/sL l!l ls..-., i L. a l •_Ot0. W c i 1 a C 1•c , 1 Y J:. rl nE` r u ~ r^ ~IY 1 (•~nf]1-V-.r~1-•^ P. 1•..7r/11 . 1l r_•1 _. ~1,-Crr . ri'C•/ i•G~V ,_ ~.t 19%-/ [17! .J c (1 1r ~ r'I~• ~n~,~ 9~i /~J .1 T,..J .r y F a~ v v. a~ ~_..C1 L• ''L 1 ri •1_ JL•!~iJ • 1_IG i v VJt'.• C• v l' L1 `~(^ ~' ~/ C! 1~.~ JC~j 2.31 1_~ 1_. 1..~ H e•.~J•Ji~ri•~ i':"t` or 1 _CF`i •e~.J •~.il-C' iri~.~ •UCea • !~ r_•e'/>- to _C "t.u _ .r/Cv J o.~ a . 4i~-''ii.:ir C:3^/ ..I~~/C:.~e liiCr=,»e ..;-1 the f r eouer7L= of .Tjs=cur rerii='e of ail urlre2r{furCe'•_i C•ei{uv.1or in tiie r reseni=c`' s' s`OrilJ:tiOris r'ei-+u1 rIrlA or{ iritErA/ltterit r Eirlfvr.=ed r exrt3rl-i'r Co1i:i'3re d with U'i :: freaiJEriCj vf a'.hct tc•LO'1l:rr wiieri r1:. Ieiter"tTi:.tterit resi-tJriar7 l:i r Gau:.ri_:•..,.• Alth0ugt"1 reC:igriiti.:lri has :leerl :i'ven to the Cl::.=urrenC2 of other .v.:-.C_-•_Fo.',.... 21 i1~ J LLeJ L• - _ _ _LiiJG r~!{ t•.~ _J _ O_3 _1-_ Ci 1C+l1~.'r= i v has /.1..{~ U f1~IC t 1:~ 1.~.• 2 I1{ _ ~ U•J 1C•J ~ i/e•J ui i: 1 MV•J L i. .,i'::iladir'==2a in a rat Orf a fcu=,reli'vc•r-"> >.: hedul2• in tii2 Pr"enerit Fo;- c., recent work orl _tiicr schediJle induced b2 :GvSors i7 reviewed Ir{c=.l.ud:i.i',:.. Dei•1a'+'ior'= o='Cl..i'rirlS in .::C•rljiJ•'•ICtli:irn wlti/ riUrkCCS:iauRtotur v sCh[?di.:lE rarc/.icte. .... These /'aiige fr'Clm .rilCel ruiri1n3 in ti/E rat to Some Ploy1r1g and niu,'•1_ -vi'....i,..' i./ S'2vmar!=. Thi: 'r'-vpei' is also COriCerrcejd with the r.='v:.Ew of :ar.'.ablt's iriCluOlri ; t ie effe=t s.7f Fi2r'iFiii`r al and central av7iire15trc t:L.". 't i_ =3/,_.. -r ad th•:t th'c•'r e r.iay be C":ther auorititufl',ii? C/ 1xu,JJ.. V=t.• ._. di flr2re.cca i.n dl a_. eff:=C.}.s thcil s.=.i2•3•l..tlE ..i/ :1..CeJdTirlirv.ir,Z is cG/:•i-ar e:: r..< ..:. a. . -_--- - _ 1. 1": - .-,t 3 e r• r raZ o C a+. y o+.. Z n: +hE v r j Cv1..1 t .._ ..
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THE INTENT r~r' THIS '.E. tlyrf.lw TS Tn I'ca'`n,~n•7•iSr..,.TC TIInHT THE L Cr-/ ,.a v1< ui ~ ~ .~ 'tr~!Ltu1n.+.TTn~I ;,r na.+-., - L 1 f u •L.,u J i n ,_ . f 1 . ccvrV~!jL•-~Tt•r~r:*rV • I.r-•,;V+-'V rS J i•. '~n ~I •JJr_ ,c A'V A~.FnnCrTTr•• ArL.rHT c-rlnlVtrL*L• : I;.~:.,r_„nr Mr•..:-.~vr-r'.•-_., J ;,... J f r ', s J/ ; ~. L HJ f t V 1's L V 1 1 V V 1 V r/ V /'~ l.! ~! V •.- i l.. • .;. . Dii'EiYDE*li:E Pi.iTENTIALl T~rS'E,•.nF•CITT ~ .!C E Lnr•1 tii:_'._ _ ^'~••F .>.~ ir,nL{~1n ~ EfrI-rIrii~.,i ~~~T, :rV.nVnIL•r~ L V V .: 1 f , 1S V J T ... .... R[,.r-1Y[Cf;'CT~•y:L^ l.1f_, 1V7Z•(~1.Jr~_~,-fCuTt^v~l•'/L C,•l V I i~~~';tnCr•V• BY 1~.{r-,!~rtr/S•IIY ~,rV _ AL 1!L C1r 7 Tr,._../r .• ~ • 1 . L l. r. J 1 .~ S i_ 1. Vr.-11 J i,ttCJC...}'~ 1iJL t V L J 1 ('~ aL1/, . rA_-•1 Dk: -A a D• It~~ L:-; ; 1~ OF .~;L~>•.,rrj;'Ct•.t--nfL1Uf-.TTn~rt r nr_ A DF,U,, J r.c F;T.51\-, a•Lf .. ,._C~EA,iCCTT RATIO C BE OaT]• {lirs~t ,/~c~ I•L TAI~tEI~. ,_ C'~:,r.: EVALUATIONS PROVIDE A BACKGROUND FOR •~.IVta,T•, Cnr. CU r.ur {"1.1V~J ..:V1L /-1 1•i nRINV NEW F`VYCH^^4Ti!Jr DRUCS ..'i... THE C,_FrFL nr r.T.~'t'r,T>jr:V ` V•nrEf '=t ~FICArT1n'Vt<' nr•Vt`'r { wN"1 /1 ar.T: I~ ti.`T1~T>`1 L ~I L• + a• 1 f. e L VVJ a•1\VsJ POTENTIAL. ,:': -rr.fi__. . 1VI !'/V Cv3:.3i ~3 1r•'~.T'`M• '' uOf1Tr'Ihr,TIra~ur,TIura~ n'- a~r''jnlf~•FvlTnVrn..11L F,l'"nr~a`•ri~.,'~v'~nr'uY -^F~1Ti~AL MODELS r_r F-iLV Va 1• 1. Y f• Vf f.l a.-, ir., ~v 1r0F'~ ,' 1 a•~J r.1, .~ r 'rIEJF:O ~, , ,<a• .tL~„J~.~ JLJr:V R HarTt :!C•Ir•ilr~T`11Lnf., _••t i „fCL. 1 a•Lf.,-+~ i~J Dr+.}n1ID}r.AnL f [./-l1Af} r•Mr,~~J . : ,~~ ~f.,•.+.. nn..rlnt:J^V• THE r.l,_•lr.r~t- ': . STATUS MELLCr ':.!':. ALCOHOL ~ P4L1G „I.C3E RES. CENT. MCLEAN ;;CCF•. - HARVARD ME::. .;C'HCi:;;._. : ELMOr,T f MA A L A N F;. 1.~..t LT"''i .t I"r,v.r NEW Yn f.,lr, .t:r N.J ~ ~•, NY Ci r".J "•'.~ ~ °ni1i 1935 I=..•. rl_..C,;r,1 _i~.% -+t1c_.'? V V V a L6ngtiGsL~•~ :~•~: ENGLiv.-! I`oLFJriiEilN T:rF't't CHhF'TGi. n r,f ~~..• nr- - . :L_: THC nEFiELInr•KE.~T r,c r.,_ru-.HfY,TV/''~{'F'~AL ! L 1. J f u.• f u f ~~ t a• L U 1.. F ~ /r•~ICrc-r Lc ALIrnt-.~nrL I~Lrr.c~•„nr~+`!~rr• 13 u ,_ s_ + . CI,~~~fi LISL~- ~.• v L• 1 f t / u r a• L, f .. I ~r~~,, , ~. hrl.-II /a ~ CF ElvlEa.ir•>,/tITC ^•C COtdTGL/M,iC•n ~f;r'•Y DClif- 1TC„ rraL ,1.,{ t GItAr~r.M,4r*+ILnG•J. T 1, ~.I^.,_T i~:. . Jf~r} a•L/• F4..,.J~T < ,~~;, ~'E~•-Ca~Tn A , y{ {nr.J/\ , a• J~ ^,J'nr_. a'fv^T~-{C7~.0L,nrIC:, a• ~~.tL ArltYtl:~iCrr I~,..r T'tT AL~ '{'O A ~,L •. ,rCEcJJ rAFi ~r<~. ,..Y C;'al:-•.•c'r.:Tl,~,.r. . f.rLF'F: L,t J .. {nlTr-•'t F. .. `-.1_.. r.n~rM / L C/t1TSCLrAltrut f-~CLaTr • afTrTT 1TLLE/" ~ THAT CJI..lLL• LEDARTJfr-. .E , •r-r.~r GUIDED f.LJLnf,{. f~rLJL{.f~ ON nP: { ., H,LCf}Jil~~~. _ . MR,a'Y 1 Ey.i•Y'ti1T1 '~I~ER n. ~ THIS EJ"rJ'r1v WILL t Tr•ACE anMc OF T/ l.~r nnMT~1t/-.:.ir v Y:c -R5c J• T~~{ ic L Rf, {.i ,.sJ 1 f f\ JV +_ V. , L a••.11/1i:f-. ~; IL 1 A..7. i n Tisrl J'T u AYL , , V/ IIC ~ %•FCr.C..~'TEr{ THE L I~Fnc`MEa~JT OF ^' /"1r~TMAL MOnclL.<sJ ' Or' AL'rJ''{;,LI"a1 ~,a.'7 , a• EY"LCLV r f / 1, f a~L + 1r / J ,JI i',:t . T•~TCC1 ~C VS 1 r, 61.!~TCa/ i'TTn/•/IL • r~C•6FLTrnf'FTI{'~ V{'' V 1 r/''F V Ir• L ..71 ('~T,Vtra'rY r+ V,r 1 CnPrQr'i~^ 1 tV>"'A!r•1-r' 1 1 J THC LT a1'~ 1 1 L Y 1 Y 1 1 V / T•~, FlL~ MEL•Ir V~, t L. V f t V,.. L f t!.: r... ,.F OF CHRONIC ~. (1,Lrnl,~ntL r u`cc•E?~T'C'+1rE• JI ! V~. V 1 L- , r 1 f + ~'r_•ACL ~ In'r'= NOT F•r~~MTT A C`.7?,air,r••,L~ + J,-~ Vi_• V Lr 1•L.f u rJ:~~etite_. CRTTTrrIL nC1v1T`f~ i, t" JrC • riILI TErHfstT 1}''F {.< ~~ UE.,.1 JL-a~ ~•` i../,nr,•r TO (~ i4,/ 'fI~ull('~E r~1_C{•.,H1 1 Ir•r•ra_•.~a•,Ta,V•,-,ri_. - 1 1 V P"~ .': L 1 f f_ , 1.. V V... ~._~ L,~ f_,t .a +. ANIM/'-'nLSr BUT A NCMr• ('~ Ei OF F.rLVa.,e L "'C>;T Fi r•c,V/If_ttnr1IL. {AL-•LF. . Y,r' rCf-. WINGER L i .r:... ,ITa.Il3rCn CT '.r Ct .~C J Afr• tE n nY. 1983; ALTSHULES r 1981; MELLO r 1981 r 1979 9 1;'75>' 1973; CI Cr'F:C r 19;'•; " GntiLa~•., / trcTE1Tt~ I. .. , ~ 1t??o: METIcJVH r : 1 •I9.•-~s r rAL Ft~ A/f ~~~ , .~ ~ •~,*tar{ • TAt+lCr 19s,.. C•.. .~0 r~.iro. -{ 1Q•7:% I / 0536300 MODELS OF TOLERANCE: DO THEY PREDICT SENSITIZATI(1N TO THE EFFECTS OF F'SYCHOMOTO<< STIMULANTS ** NEUROLOGY AND NEUROBIOLCCY VOL. 13 BEHAVIORAL FHAfiMACOLOGY I THE CURRENT STATUS KILPEY, M. M. ; SANNE4L'I,. C•A. WAYNE ST. :-lNI!.'.: BETF:OITr ;^;T ra'r i~i.. • .r i~tL Y nC NEW F YOf;hvr Y`t/ ~~ t~~~~•i r.%. .ir 321y 1 c• .r LT1JJr 1,t~.f r,..i .i9tjs.c i.i ..Ji•~i. •~i. 8L1y -r.' 1v-ti LorFlual2s: ENGLISH DocuirFtilt TypC. CH/iC'TE i'. A • r0~.' tC JE1.t L V L , LI ('~ 4VIC}.ifrC ' !11t_• h~CGEI'~f La• a• •TCT~ T;rR, IVI('±lj /! TSIrMIF1' <IsC` ~TF~ ~'~Af NtLr-rI}:,STTr~a1 1rTT1n V/'a.! { I;1^ • h ,Ia, f rF~.r-/ , 1,J.t ,. i. RCC60''1STtY_ra,~r-cc TO THr nr1FV/C,..~ ~^ Ar V 1 1 ., f V s V 1 1 1 1 VTTO''~ `- W'TTf '~ A `~ r`-I1+1'V"nI"1TTA"+T T~,,~rr.}.E1~`{~JL V f\ 1• L L•Y: v!.~•C nn nrr•re's•~.~r..r., 1 JI 1 1 LI L JJ I L a•/ , TN THE DOSE ~'•E~~UI4~'ru , TO ~•cr•rr}.Qar~ u.. L . f a 1.. . Orc Tr ,~r Ta,,~TTT~nfL rE•r V.r Hus_• , L~ ~r;+Tr•. Efr1-T. T, ~ f 1 fL a•uJL. .. ~... u L~. r•."..rr ,~:.t:. THE FiCt6.i'iTT ''.~~~~;-iTr: I:rTli:•~I'C~ft 1 A UNIT r~nliJ'G I•nfJc .r'IrL• , f,nrc~•,C'.~c'.. L1F-n•i~1i il 1_ f L.+_ 1, a,.JLr_ AY'`~n ..• A SI'ErV.~F- L.=J+ :t..~ 1,-- ALI TERETt ', Yv'IT/. ~ MrV,lL.TI~'•tLC A I'F'I•MT~'tI`=T.} r."nTIOi+lt= ~;t~~"ULTI*~r IN A T/TIf~T'1I~.'~rr cCrr_,-t.. ~. r 1, L ,, 1, J sJ f sJ / V 1, a• .,. .. f v•+ L. a• L. , •,_ , <TOLE4A'dC`•'% OR I~•!`V'F'r"r1'~-r'~a• r>,1r -~/~l'•1 F-+ ~r. ~ 1}1 I~HT t}r_ T('~ T f L. sL..JL ErcFC LC 1T . rc.JL..'tJ I TT 1a. In ViY. EL 1 IVL i L1 r Hc L T 1 f<..,1T?'.L A;-- r,rti:1C r'~Lc~1~•na.~:J~C rcCF; RC'vITE~i. LL I SCr_r GrFal~4L ~,LT,rtLILf ,-. c, . J••/ ..J u.tL. . i L 1 T Y•iL • r i JvO AND DEMi'iELVEJK ['.7CVa• 1 L IITrTCr 1963). i CCErTC nC rIJr/~Of t.~r,MT~/s1~TVr•Tr.ATT 1n V{•f af CrF L~ r~ ,l t , (~L I~ e^r-L•^r.JC}'.l~ lTIT-; T{-'7F LC E V f J V i v AtIr V %•,a• 1 1 1 1 1 I~ nFn Jsl ~' L. f( l:!.~ ^OANTTCTC-r,a• a ~~•f ~,Ea'c,:,TIa~'•J' ^ nr~cc_F~/~cnc•/~a'cr rr_IL/~r1TT 1n V1'ts•.~1711 .r ~~r•tJTr•r• V 1.-L. V L. 1 L~L/' Tntcr.i\:.~ar11't'rr• T~.J nr_:-1r.", 1/ 1 L SL+,~'1 i•L JL ,_.~•. V,Y VL k~L..'r_f-...41 R r'T TO THE ~ .• Inl~I,~1T IN I r I-•.\I•1TC>~~ I! ~ ' S A C J I~7 l Ii1 1.! ;L t3 1 1,< T 1'~, iC L I~n V JI_(^ CRLCC ..+fr.~i,' Yf) J,..r• !}f}{. 1 L f•tT / : ^ •1.JGr_ V EC J 1T~'t1_• , THly': ,. ~7Il} rH+-.r_- IS t''[.r{l.~LTi•Crt Tn c i~F~r•rr1~•TtVtrIS.c THE IiYTTT~niV CrF-CCT• C JCLr~~,tsr1T1 eT'+~.TTn1 ~~ T,`a ~.r_1~i I' •n V ~:"'•L 1... l t.L a I V V I L. I/L 1 f 1 i^/ L /T ..i1 f 1 J ... DEMONSTRATED a• ~:Y A ~ .E,r_Ttf•nr~wf•rtinr~ S+iTCT IN it THE ~ r/ a•OJf. i~L.~f ftJ~. u/\a 1L t c'r c••r_nr_.O.Irr_ nr•wnf~TCNr~' ,-, 1 fSa ~ , T• T .L.v t / Tr,,.,.•I-... CF'HJL THE L ria•. r u._rdn•Ir• ~. nCi F •'~i^~LTT-y ~~n A ri I Lrl.wtf_`~Fl ~ it.1L TO f,L1 ..- THE f.,l,_ t•~ r'v•r• Tn qCT~F~[1JrTr1 .~ TC T~r• ~ Hr11uTr_ il._v. ~t~.~r .~ .i.1..., 4B^rC~v~Er' .V..• ^r.trF.L.+ 1T83). :,~trL.•. 1 L ~ V ... 1-. V J J r f. DRUG , . •^wF'1l~vnr TP-'r~^JC ~i-f~r^TS:. Hr ~ /,il• s/.-TTC~...L u^FVIC T~.LhtiTii..~'.iiT'.i ~. a. . 1• Tt-~,• i~i,} rF~RL V i J.L a' r 1 + Y V ~~+ rr''~~rV~^TTL. r r•TJ'.'L~VTT~V'}'~~r C Jr~r TT?..~1TU i Y J L- L L/\ 1 1 1_ I(~~I`. [ t.7.~r T air-Cl..< i Trny.{rTa• . T1 vi Y4-. VT 1 1 L/~'L COM1! L LMi. Nr 0 iOLr'.•.-!~t~r'r'+ 'l.t•n.i iJ Tr'i .... ':J ~r .~^:^L a_•,-.L -1 TrlCI}nn?,f1rv._rLr T ~~d,rr:r,f a ..i'1 f THE ^ TIrwT Tr,C . r'n _ ~.~.[r' p~__'.1.;-i. ,_f.-.<.. :. T.+~• ~ i 1~: ,_. F•EPRrr•^~T .~,~r'.J1r ~TT~L. iw:J J OF A f', rnMM•.Jf'~N 1 v MEv ~-1/~H~fst,Tru OR Mrntil~' ~Y'~alIr~(n •r~,;"Lr~' LJL,~ i . ~..... , 1-•1.J, r~ , L vit J/.a3 ,_,~T~f~i, • 19Ri;. .'L r-C;L., ~ ~ 0 m H•• OD w L43 B 1017113 „nc7L7r,~;
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HIstoRlirie reduces o'vol••'~.arice i'2sr=ar:dir,gt an 'c'ffL_.,. 3aedlate J via Hi--r2cii-tors. v/'•1ai/ge5 • ii dr-Iifklrig aii•:i ailTessI'Ji:• /_ :-/'l+a'v i... a. have Cl so bC•Lri .JbJC r'v e•J f:Jj Jowir{g i{1 stOR:I1• e O J/Zilr/1 -t ra t1.J}i 6nd r 1.11 G 7 f 1J r I"'' 1 C11•J F e2- rC\. ei t1J rs, I/CO've L•Cer/ •JL l 1 r1e1Ote•.J • SCi O/ O t C HL- _r r.~ Fia'- r'C1• Ler tor me ci I O ri 1stir s 1ia'v e a l"J •rJ L eer'i s`J.3.3Yd stnV tV SLa_ l.. s.7iJ/ rt f a.} r criOr/ZGs Clct i v I t'1 l C'•V e l• .Ji 1 j l L• C•11e H2 ar1 ti>jV111 :,it :• do r/V t O l way:] / IJvC st r 1.1r •.,.r behavioural effects w`t°rl adR/2rilstered T-2r .ph2rallys there I.. 2'v1VC1:c2 th„_t cI Rlet 1d1 rie /ia s a dCr re= sGiit Cf f ect an st-.l uJ a f`Jr:ct i W rl • These and {_i i'.r r... . flridlrfgv r'L=''vCal an ,lleii'ur'taiit rvZe f.:ir iilstoT.l:f2r's1:- :3~ShL?iL3 lii o widC rc•hA~: Li L'CIL iG Y IGu1" • 1170 F.t.' f s• s• 9/7/5 06591500 88235500 RadIatlOii: bc'Lia'v iG r al IRipZ icatlOiiS lii Sr'-ac2. E{G1O Yi Armed Forces F:adIVDIOlo3n Research Ir/stitute, Hethesdc, MD 20u14--5IfiZ. To;:icolc» (IRELAND) Mas f988, 49 (i 3) r-2.^t; 30?, I.^.S". .ry/30J-"1°3`, ja1lrrial Cade : 4'UF: LanS`uales: ENGLIjH :i.'.{•'i(:" 2 i ~ ~ ~ ~ 2 future _'~c.t=2 Riis=iCirfs are Ilr'•.2• 1'3 o a •G 4c Ic~':ii~i••.~ r ~•o../+ 4/ir s PrGtc•cs 4.i. ~FRic~vr"rf-,/t -.r.e, ~. -. :~~.te,l ~~~:~l,l.> >i~ ~ • 1 .c-,• T:i•_c / ~_,~ ~4~•t iif:carit / L /a~~o•_YJ :~ ra•JJ: .aL4.. E`a'•. •11.~::: ~•lelia'I 11J r0j s1 tS.iO ti Llr10 •- re O J•Jre 7se d in thl O pOnIC r• (1) sY'OI.C ra•,J Z at1 V//J /fi i•J r e e f fect1'".' e d t J 1 sru% v 1 r io L+ c 1 1(j '1 1 Q r" y (2) tas.•• ,.j l R, V r/ +•J n L^ rI OyoTC'v G I+ C j' fJ +~ 1 O lr I L+ rr - IJ 1~ T`J r t 1~ r: ~ \.J i e f f C: r ts t V RI J t I:r O t i V 1sr iJ i 4 1 V 1/ Wit r r iJ r J:> > `_]h1 e ldl i•{g OrG i:•.!t sOt1 ^3f aV t1d ry Grld thC druma 1- O/, L• C b1.. 1/ lr 'r i or' O l l 3 tzr:. 1 i- , (4) Sr=ac2- ariJ r adlatlOr{-1r4f.'tiuc ed e7r2sI:- .:uRIL•iria••J. Rfan b:- 3'drierll5tii. Th:i:,;: future =pac"e travel will be a deRiaridiri3, e.:citir:s t::aia for te`/avici 01 t(-•li:1coIo3 ists/ t3r{f.•j wll l 1 C• j.l ie 1,s ir l. i•1R1 stG9Y IL es R1a)o 3eC:T1 111'3ur//r V t1`/tvr-+ l G ..i i flr _',t, .=^2atl'v'c 3i-i-licai.lis:'"/ of ;c12ii;:.lfSi= +2:.P2rti3t= shGul•:". 1ll1,••l„ SOlUtlt3ifsP _lil:ilor to Ge'R.ai1dln> >Ituc:t•'.Ur/s .=Uiifrilifte••~~ i=+Lf•'.re. (44 Rv=f:..i c e!.~; .., ... 06554933 93177933 [The ± e I ii tC.'3 T..-- t i 0 rl iJ f bei i o'v i V r" 85 a 'J O r 1 a hlC I Ti re :ecor"Cii3 L~lrltegrotii•'i - ~o :_u 1 ~ri=:~r4 eRlcil4 4 cOReRfE' 'v'ur~l .al:+ 1 ..2 G . .~• 1a=:r ~1ri=:~r4e Rlcil47- 4eRlcil4 ~;i1-• i iiei _.KL: ~i •t F'oac:i:~i i o ra.c::41osi i.1ut r `l2ci/e1 l2 ii WS DS-. '-i.%y /C - . , ~,•1~'~r^) 1i9qV^ 1 t 1 i~•1/~_^r•v' ''*~ a1'~.a1ni f r 1~ 11 . ~,.3 r i_ <~r~ art1- L r• 3 60 ~ n r,+ti1~!~1 /i i v I 1 .rR ti.. --vir...n. .., V•.J r/: G j C1J •J L• v r P ~ -1{~ ''•-iC3 'E'• C'•'C>'f`1 ^ •~J ~rRiRiO 1 t ' -r' -O "~• • /'a ~. 1 Y L~ '~ ` .ar1~.~. tiOl~••-• ~• ~i•tGL I M T i'i 2 P1 a cG' of aii I ma: bc''• il u': I u r a l r Cs2 a r"., i-f a il C. ii a r. discussed. The ad'vantage5 of the R.Ost refined tcchrlit'eUes Ci •V a i l t•i i.+ J e, rl C lir C• i'3 ,J pC• rO/ 1 t 4• i.! : i\J 1 t a aJ 1/ 1 r is, O r e J C.3 L I' i L C lJ O 1 1•,•1 1d l'J :3 t rli 4 C'J .V .i L i~ eiir~] CTIR/Ci i~' 4`• " _ 1-_:JI ILG/'i,11/g l1,tr0 'r.J+J:l~.Z•J ..t ~ t•JO1 1r l •l/t!'r./:S.{I .V1•.J .J• .•.JO.l t~ 1: ~ , _iJ : • 1i 1C 4~~]r3vCl. - ..a.;"..•. '~jr/a a., I SQRilJ3erie i t"7 of J r +Jg O\; t 1 Vrl ; J•.J r® V 1 Vr'i V E C f f Ct- t 1 YJU sC-/3L +• i:+i i rel. Gt 1 L•i 1sr 1.•. r , toy e rvr Ic e 7 C•r { t 63c+r I 1 sI.r 1 $oIlerv1s./m al l•J i tJ te/:t! at 1 V r/ • Tr IC •- v 3S1_ ,. a.. c orlt 1 1bi.Jt l,.~i i of an i 2::i' e ia l RiC'i ita. ar.o l» 1:J vf dri•ig act 1 vi 1 :i i /''•..• i:o'v L or 1s r r.-. „ t0 tii8 r-r'edIct:ion i:if t•hcrapc%Jt:c +'-ropt=rtl2a Z~•'T•t_r.iliy f.rv i•JCJ lii p_,r,:.D.. Vna 1oga cG1 O ri •J J 1 I t 1{ r 4J !• omtJ r i r t 1 1- r C 4sV 1/ 1 1/g A.1 ut t/ 1 e ,•//.1 ar.'] v a] i 1•J r. r in wfui4ctional ulc.:h3rii3'.=s As an e.:alifil2 of .iicii a Rii.c::on., m• as ui-orv,a.=h_t .___ bE'iia"vlor-Gl Yc_rrniauic5, thc tr an5°2 r of sei/a'v:.ai o.'. ef °2cts fru7m drui:3cs a....
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Ln•Kt!{ ':_iiVG t _r }"1 re G_a-•J JCmaV..!Or r• Tr IC' irZ/c.ZpOl , O`.JYOI/t11i[ of 1 rA,. 2•J 1 O k.,. al_ .c .. rr. r- .a i•_ a, ty iJ f {J S e 1 :ot e i r t i iu t I u r 1 V f l• lood .::ff iCac'_ , and •'.r t2ntlol ._vu1"iterbaiarla=STIg of Cer-tairl Siw._ e°fe; .i,S. fi" dLJ 1 t 1 or r.r i •: .J .•- ! i V Jlti r a 1A1/ Sa r-• e ir1/ p/' V v C' iT/ C' I 1 t 1// L' r U O•.J -bOse•J -, 'irY f f e:_ ±;i .,r' 8 i i c=- 7 7_ K•= t i S i :a F' C• t c• r i t i a i r t' •.~~ L.i C t:a orI i r I t• i e ri :• e~.J: for f r c?:... ... W. 2 ci::ICirct_Ir= _ar':i:'il:,r-ti=e arir•~~ Iil the freC+{3r'iiC''.i (if 3ff:.Ce vi::'.ts+ Th:._ T'rIr{Cipai disa17•vc itage i5 the relative I.'If:e:.ib:.::.tS of do.Sam2 adiuSti:ien:.> '-3~F{ _+•r ~ _ ,.~ L~ C_V , ti ~i~rC~-rtCS.l. .C' tf 1e rG1C'~ 3liVV 1/.J C .f.l il t.~[~tY..•' w 1 a i 1 O s. rivi C V..r _r f' !~. t r C i~ 13 r a V 1Vri , H 1 VLI s'JL`_•'Cl••JC•f/V '3~.~L'sVJ•ti.JViV f I V f a C l.j //r bJ i 1 6 Vi11 r/ r 1 1 Ju1.. Ji /'I r r_ 1 i aF'P.''C•i'r1otC. iaVc-=. 4 aTid ..5 i SiJi'+.hrarizeY reSpeCtl'dieiS:/ ;oR{e of the iiu=.:irt_.r/~ f Octors t 1.i Lorl si IJ C' r O TI d t hC' Vhe V r C t J L O 1 T G• a1J I r e mC r1 t:7 W 1 1 G/+ 6z nr 1 taiT. : l:7 Yi/ rz t_ r a.. use fJ.,.:eG_J~- :Se uli ~ta~l•~Ferter{.1 L2ria. .iOriS.a ..iOriS. . n •:. 'i.~Tea ~.li=lbea ~or_ i of '`e CGGiLf 2ria..iOr i S._C'C:.... r con)viTlatjoi1= vr e L:iperleTice wit',i T-C•r 4i(=ular:5 ottroLti'vp CaCh Cume=cirierit, ti e:. r bera%.Jse of the eiiJr TItJu:, loTIs't,:.. r., '~r'r O'Jer{ ieff;u r aCu anv ovGStiorr_..,. ~r :~81'~toT'y effe:=t1y tii'eir SrQT/Crala, oi.0eptabie aT{G '.Sui.i2tiR/eo effects, a l'J t'+elr otc2iitial for or{:=e"'a 'Uan v E i,' •J jur e t 1 c C. r J r G r/ i v- i S I i a'v t Cx r e a t lii C ia i t. (80 oFfs;;tti:.l {Jvsir13. Zt 32cTi5 : ikeiy CaiCll.fiu-t=hercrl?3 CIiClC.:•.er/•-'~lioTeti.. C.u17ibarlutio:1_ Fa e f '_, • . J j C' . /~ / . ,3 06369470 88014470 Behavioral i-h.;rT.;a.=t'.Og'S ,1 a T : e '_ Xr of Cer:tra: Tier v0u5 De='ar w'ce'it of T''-=gchC1iGv37 ;tewra>=', re ri,iaco: any J U{_I r r{ O./. Fv 1.f de• N.L L• ju1 l.! 1 / j 198?, sy'-term sti7l..,ari..L. '.'•erSZa.S G . r •.::wa9 J. •L'.~ 52242. TC•~•)a ~..i1, r ^?V (7B) nn1~-9^ .J1r Ia. ~"v1'! /~ 4ftf~•U f ~1 ~~~-J •'~'~,a_ T{~V ~ CC Ti t r a C t.' Gr.= ri t NCf.: MH.i. 6:•4i L_arizuc•SE'= . ENCL: _ i! . eTit r!_• j eIG'r'vi}U:i j'j jtCL. st1 i3,+..ij aiits i: foir bc t1Jd stlr/lui 7/1e•J ZJn the .•a:a.i their differentiai effects in various behavioral t,:sts. There C r 4 sufficient dlffereT{cea tletweerl these drlig5 ti3 Su>;eSt that Orle Cvu:~~ develop CNS St1m{..J:ar{t_• with more selective behavioral aCt?OriS. i:9 Rcf•_. 9/7/16 05359950 38003960 ET,vircr{aler{tai cOr{ta711riar{t:S ar{d behavior dIsOr.'LPceT"5. We i ss P Erivirc:nrs{ental Hee•lth Sciences Ceriter, ()riiversit`a of Rochester School ,_, Mediiirie a:id De'itist.r_y v.Y. Dev C`haT^i- i.~n7, ..,. 10 lr1 r346~-c•~.J, ' I... +~~+>,1! 0T„f c ~- ~oT . Tr~e^ .. Uf '79-n~•~"r,^.., j_Vr•J.r//O ' -,1 V:.J•JC• ' EAF •L 1r{,. ~ra".f ~ ~+:rrGr.• i~' ,. . ~`C.' . .~.J ES-.4~1"r7i ES-01`~~. ~~'; c ,si E" ~-Q3:: `ar1l,•-iC:ies1_1S L.• .1. v ~ r>,lrfL.r.^11!i iG^' disci i= i i i ie C•f bi'•i ia': :. oTa j tl:fi:.Z Cl] i v.ay is aT i <]i ki iOvila•..ilei.ICi iji, {.: r~+. be'iia'v:,orai S?=e==meritn aL1Cu:v T=ia'.d •i r ile ..// ,•1,':•JJ=1ris the S:•fet'1 ._ ._ ileriii i G i s• Su._ h G rV i C .1 L Cmr iia si zC J L•.3 tI/e tv,.ii IJ j 1J_] aca. i i1 A. st{J ry of n... --. d:e.ffer2iit 0i-S=c:: of Su:=ta:ICe.S. Tr-1a:Se IrfCiu•'.'tie TrctalSi •v'oiatiit"- =i oo iiC: =oi'veTitSl aTi•.~~ ?_JeTi flr0d ad•.'Ji:t:.'v2s• rC.r aei of thC:.:..t i1,-.rieTlt to:..city o`aten t•=:-.e5 the fJrAi of S{..1b.J-e;=ti\•''r'_' Comr~Jaii/ ~ _ t= t,~~at ...r a. ~ later followed r"= o.~ ' child - to s CT't i7rT~G 1 rTi t/ 1ts• T t/C' 1 re t~.Js v~ 1' r+.J yV~~//.'3 ~LC// t1• r_ a.. a t :] reL. i al r 1: k f V r 3uL.131 V1?~i 1LeJ s•J ' l..1 I ~ t73 'IiC; 1,/ : ~.l ~ , . OrlJ, »rl1 a, rLIC1 v.i •L _ ~.`-... ~...l:' r fr1:r~~JTJ L •..t cLiiv iS 9 c• .J J:C.Cptibi i..;.'_ Tiu: fi_{liy r tLUSTIia t.'de (%2 F. 'f S• • i 9.•• 7/j -. 05530343 351463,0 Fire-=ettirit, be:"/a: i.ir iri the s 1IStu-TaeS of a state ~ _.IV_Jiia_o... i•iJ=~~.~lo4 ~ l~ s.: _.. . GeiltT jL: Bertsc; .:. A3Fi i P;.=Ci3.actr''a npr i9v5l 1`fl2 Cft) :4N4-8, I.'JN r':~..~2-9caa-; v 1 f .i0urrlal CG 1e : 3Yv Lo"Tl - 1 ~ ~ Si~o;eS; E?~~l-i •i'i C 2'. i2.. of the r ect.;rd= Of 191 rfUriAt'rlatriC state hv r:a tai in/=a tiak~: =• ~ ~t F1G4•1e Cl \.!L tC a" _ :.^V•. ! lJ f the T-t7 t 1 t•/It ? I(7• e1 r>6gC•J ! 1 i JSJlliE fU rm fire-settirfS :•'c`IfC•'r'1oi'J half of ;'-/ 1a3 g1~U'Jf~ had ' E1 1:34.J . ^l."^L ~ • .~'•~ a ~:Ji//'1C i _rj_ _._t-'_ t. ~-:.r1 & As ci =.r OUi-, ?erSvri=• who r"la J eieaa3e•.'~~ 1r1 f~.r 2~-Sett..ri.~ ~•eriava 11 ..f.'r Si - ~1~ ,J i~~UrG' !. '• :i.CJ~ •r. tV 1 r >_.O•YC a t ~• iJ •s4 t -VT~•~ • of _ ..~_CaV.116.a • :7Cl1 ~r '_.'i{Af1LO.i . r /IVf / 1 i 1aJa. 11. .. h0 :1` ho- -ig:l t, +lramjar r:u6,:12r :.° a;;a.i-.v.•In-, tn 4_=,.. _-`-
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BT^_i.jJ.i r_. r.T~_•rt, `~'J '~ 1l. ...l~l± r'1:--'''`r_~r~J'~:'+a• ... THE T.~{'c !H ~r..i~Q14 ~ i-f .d.r V i~ .~ V r~f a i r 1~ W~r~.~/~~~<'~~'=n nr Crr_yr,j'"r1Tl~TL. ~ ~;~r,r.J._ „'.T.._~~ .a V ~..H . OF MG"r~:'v. •i^IiL TLL'.'r=r•J~J 13 r • J~ ~• Ti!'.HT IT HARDLY MENTIONS T!-'" IC- '~•l~E ('~r TIv~f-rf a. .a~ .~ •~! a. ~ r+:=f• K'.~.i~•~..~ ~_ ..,.• V. a~ L._ - /•~..1`+~i1 r. .~,r_.i~•;•r/L. • r.e•,nr_.T!_ A r S'.^i ~-TQI C'T ~trirL•ClL f~F . ~ rJ_r• ..3~ ... .. ~L,r .. _ . f•TIvIC•.r! i T;'{rJ a ,a ^ nrrTf^Tr.._. . 4< •L,~ •~ ff na•`1r i v r_,,,r_ a.a,r••V~ ~i.= tT ~J .Ii._ U T'.T,r'Cri • ,L.L I T TC r'T~+ti7a, A r-t ! 1 ~•CCCLI+a. T`VT• IT . A V ..• J'\ / /_ ._ r i- ~.i .. 1 .~ . .~ r< ±T TCJ .t ~C1ILIL!•Hb~Yr',~.PfTiT iv1r CrCnt;•T f~r 4"~11Y i-i . l.~ •. ~++VTl1'•tr~:=• ^ .• r~r~ .t ... r ~ v a. . :• . : i i; .YtC L~.~ L .' FOUR ~•L.a,T I!_` J • i! I~.T.~'~•CTL~•I.t ~~T^ rl.~.~alr' rrf>~~Y}!~• n H7~1 Ov I!E\ rlvlIi= .~• •'1w1r • ~[~T.T1(v',~rlL i ~T ~ r r....4._ x .a r Ii!-~ .i.Cr_C•nr_ylT.r•:-it+_ T y+rr.~?.!'-V4~.v~'-~~7..: ..+ ~ OF i'Sfi~.•fOi•~r ... ~ v MAJOR r'^J•!r~J.T r~!'1Tr'Tir C`tWir'T VI l~~'r ..,.~'' i .~ L• /L A a.•.i.~V.ti• v ~ EL.t.~Tr FL~T~T!~..^ n/YIL r,Trnc•T~Gr• rIS~!'.i `. •/.+~.-. , . / rq~~~~~. `~..1•.•i t ITU'h iL••` TrF~Ti .i TT '` . ''. , refs.. 1Crr?;'1;, 0376376 LICF.1[~Gi1_. "S..Jii~Jc;.1 Vt { 1 L L• Advances :rr behavioral i=tiarir.acol0g3. v. l • `• Thorr=_or;r Travis; i:ewsr Peter 8. :ed.:.: De'rt. of =•slclliotry9 UrciVerSlty Ne:: v cikS fi cG• •_1. e i.e a.. F' i- essf 1979. LOriguage .3 • Ei i l 1ij LI Ma ti 1J r resG a r L i i area J coveredr and a of Mirir.^csotai 263 r • a•'•"rT n w..•~.V/~'J `~•'. iririea.o:.; ~ sr MN 5.c ,-n. , - in behavioral Pharr,iacolon:: s_rittietic irrvol:irig the erfe; t= c::+-2rlGie:ltal :3S=oritarievu= C.:rerier,cc effects of effects un iiie..- 4i_i i'e /iier. t f«ri c t 1 V 1 1s o ri c,•i1iL,v1 = of tr-syci,cpharmaca1ol=, ,.:c,- arid arialytlcal review of sIlrilfli=arit fo:=toT... dru3s an the behavior nf both iiUr+,an! ,~ r., is PrQvll."'ie+:. Areas c.:cVer ed IriclL:de: ar u3 eff+;i=t3 .., 1ii iJ t o/' .3 •L t 1'v 1 1+y 1 r/ ar.L cur rerlt ctirldltloris drugs; the effects the R.oUsei iritE'rr0::tl.:ir;5 omGrlz i-T'.i.;: i' i-n t•ile C1:ater?•iriatiu'rf of .~'.••3:iaV1or and of tirugs or; rr.ale -•exual fu,rctic•r; ~.~i,..; alcsnlstic :•2iiaVlorl F'sjchoTiOtor st:.Aiulartts ari..~i hai:u,=irii:igeN':::• of various a_^rectb of Self-adriircistratiori 3;id reinfGrcin_., of di:.J:jsi p2`Jcedures for rie•.'J~tic1ri! drU:`• ii;tok.?r r e i- e c3 t r V a i oui. si t: i.i rf . ci fd dr i.] .j C+ + cL 10/71f 1 v 0368858 HER 1482-3348 0 On the arlaiys15 of studies of cholC:e• MUlllrsr Easr,onn; A5urtwai+.yaf C?`tiristiari C.: hor;ohoer F9ritiioriy jr Dept. of Statisticsr Trir;ity Golleley Dublin 2y Ireland ~. ^?-r Journal of the E;;perir..erita l.erital ar;al'~sis of Behavior 7 ~,'7,f~^1.4• .3'-r ~.._T~"9 i9i....C t n. . Lori:~t.logt_"..a• Erf3: isi1 Models for data ar .:sirl3 out of e::peri7.ertt3 with c.:;n.=urrr=kt. Var :aCle' irit2r''._1 =CiiediJieS are 2:Caii.lrie.Ji• .T.rl a r 2V1eW of i.v'..Ti 1c_ ts u° V< _._ from 23 different =t"+."~iles of ...h,71LeY :r.~avRi :197?? 1=Vr1.:luJed +..iia t :iiierc1... «nUeruic.tCiilris was mDst co7rT•oi/2y observed for r esi'ortse:ar the t'.T.e meo=...r ._ _ier ie rc 1 iy clJi 4f or-/ire•. to ti iG' matci i i rlg re l at 1 U'rr a A r'C2C'i:aiT.l r{a 1, i V r t of •!~,.. L'Vi~~ J .~ L'~~ _ .~ ' C ri L C f•'/~C~•Ci.v'~•''•J 1'~ O U.. I,i 1~ Vri1~i'.1•~.• J es t t 1 O t ~Ji/~Gr11iVt L 1 f i ri 3 1s F i+_ MV.:. ,. coRif!iorrin OL+seT"'ved flridlrf f^r ;ot7i A.easurBs. Usie of t'ile cJefflclr it +7c+ ..2r^il tI '-o • ~s:i+ vil i • T.~aUn aJ 1 1 ilT1::r:y ~ i ~ ~ 9i~'} ~ ~ ~ra ~+~I L~~l•J ~"'J2 v ~ ur usy4 ss:Aa wii:_ {T.atchlrig o;=cur'= 1= 1=ri41.=1:.er an 5tatlstlial gr'ourias. hHii :.,.lt2r'iiot:.'ve t.o i.~.,.. 1 Gs5 i+•i r- r=d1.= t oblll t'_; ,_n r i t C i' l o r1 i1 s2..' t. Ba:.i Gr 1s Pr "' . T h.. ~ri'U~eU j _.?`a+ ..: ^ t..: -.. •- iio-_ o = _.r.~.. ~ x ~~.= ~ ic oi-c•i otll:.rioi 7/i?arliri3 aii d Is reiute•.J: to th„ u3L..... i._• r at i:i te _•t . i t F„he ref Clre L arf b:= usc /,} la:j a for{1•a l test tJ f the iiyl-,_ithc':::.. ... that raat,_':ilr/=: occurs. Zjauif• also su»esta that slvie Vi.l;:r- of betWe'c'•n ..W c?•ild 1.11 can `= iun3lUer e•.Ji go13d a+=pr r=+i:l7iatl::.ris to liiatcilirlj. i t is ,=:r __.._ ..• that e_tcbl.siiment of fl:;e•.i'ariter°val as a criterion for icteimlrilm=s wir..:i, ir{G/tL1{ .rl=•-L..rl=• .J A L L1_i~r = ..s jilaP~i-ro:~rloote. Y•s CViif1•.~Cr;` e~Cr;`e 1i.t2r'va.i L+ase+~ o~r l.•!-ie Ci=,,.._ fr-oiSr arfy l2'ven G):p-rl.rieiit is su»este:. 33 a iA:}r t `J~.• ~erul i .rC•JL , r,a~.J r . c,s=•essi'rer.:. G refCrCrict=.. :r~iutilor esLstrci•'.t ibaJifiedl ~-s.~1.. .aav~i ~ ~ 0..Zi6`9 i!i •.• i- i ER1 T 8C- 1 1 i i v c :: tudles lri the be iaV:.Grai tiJ::icoloAid of erl'vl r orir.lerltoi Wei'==.! Berirc•rd5 LEvi:rtf Tiric: L• L l r t • V f ', Od1 Q t i1! i 1 r.t U A Sa >> O f. J L• iV r//ys1 L sy V r/ 1 vers1 t J of rr'. lf _/ 1 a_,._ Z'icdiCz, _.- ~te,': Ro~- - 6a^ ~ L "t/it~t_t~'rf NY ie ~.. Eriv i rorirrier ital Hea l th Pe r rpec t i v e s 1,.~i:31'..3.cJr A iP•ief rE''vSE''w oF b2La•v'iJral tu:C1c.720l:7 of en•virvrfR.2r.tz! C.::rltamiriaiitB :/m }t:.K: a>: nrl t.?•ta =ff=rtc .^.f -•=rt-.nr. r?i _li'! f: .q
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;iffereriCcs in t_F2s f resi=+7iise can ci•tartce tt'li> >erfsItiVJta to Svr'=rressa.i-.i4 UfI -`- e '~+`;.~ -rC - -G-': rC_}Gl~1 ~ ~'Vt.A.l .."•e { 111 1 '.~~- • `JL:J ~ - _t'_ _ Vf I1•T !1~.FrJ 1•i ~. '1r!e ~'•J .F^rt'~~vC.-d '{t"L1.. _: ' •J i] 'V V 1 J Cs ri C C' 4' C' hG'. J 1_ . .i 1m1 1 Q r.l y tiJ L i/ l G rpro//. azi r{ e> I/I V J l f A V O t 2 1J rl =• ..-i f .. r e r. c':F'er lric'ntcl F3r:::meter"s and t=GritinAeiicie:i allow tha Tleasurei..erit ;::i ~c:ualitv?i':c _ :lffere-ices between the ^• drks.3s. A1thGc13h the r••ear,2r:; cf t-•.'.L Cor re:atlDn i7f the fot2i+i_a V Sui=r=ressarit effect a Gf certaJ.ri i={-ierivtf-i1a: ilikiC: J: ~ on •.~~si=i'Btc +=vriGitU:7cd a''G1Oari.: e:e re:3iruri5e5 Irn rats Witil the FvteiiCs ._. ` tileSe C+:'I:.''Gurid= ir{ the clirflC 15 st1Z1 r1Gt oi=fiareritY the re.iui t, a. na.. 1Rirre_siVC. Muny ag2rit3 which have 1RlpGrtarit clinical effects d; ./1=. .. ~ i,~i-ire3=• avoidance ..~ >_el'^lo~.Y•lOr7 1ri!''J, Catlrig t`.'a.'+ +`,1s i/e lt` _ ir. _ : o2l .:~Ca ..i'v21 ~'~ ~ ~J~ /l, !.•/t~•..i ~.:_. a universal test for trariC.u1j.i:er's. 64 references. 1 VI 1 r:' / a.l V 0010567 T, IS197" -^241J -' A J _ ~~ru':5 irk F'S_•C'iiG1Gi'o± a COA~l~cerctars Grl Travis T-ii:l7.i-surl and ii S~lo°.e= 5- S:t i1st•er's bciiaVIGr,! PiiariLacoIOgy. heltis, . . B. !_aborator-; of Psyc;.GbiolGasf Departrlierit of F''sychiatrof Harvard MediL...l vL'iiG i~lf•-~11G.,.+ ..~ ~~Cr'•. ,~~•1~ C1.4 F~:»a .Gri!1 a.Gri! ! kG l0 -.5s• /\... '7 1.i.C i~lf . ~~ :.c 1 J. .;G;:rrtal of the E:.Fer'1l7ieritai ArialySIs of Behavior 13(3) :395-4pE•1 19.`'0. Lari5:1SIEs: Er;llis;-; This is a d1scJ==lGri of the reiatl'veiy new field of beha'.iG'1..:.'. ;;-cara•acolGly. The f1, at te,:tboGE:• in this field. Behavioral F'`iarmacGlam_ Travir Tili:,r.ipsGri arfd Charles rti. ~'Jc"hiJStE'rf i: r'valiJate•.~~ and tcrr,e•_~ reflection of the relative lricriaturlty of the field. S.+ppGrt :.- ;1'.cr; t..., Ti:GR.pC•ori and SGItklster 's 17ec1s1Gri to exclude 4 areas of drIJm effei ts fi'C,;., ~'~. i~ri7 ari'J a: ri1"...,. the a1GG: u.GtGr caFa.:~ilit1esf serisGr s f1 Fi:C+ ..iG~i_i ui.G .t;'vut:.' and 1.? Ti`'iE' C:rtceF_` G•1 ~. ~ 1 ,, f! •-.:.~ -~F'Ft•y....1-_' rreseri{@~1 in tia" le ~ ~i~'iG~~. i 5 i-i1^•Lk.~~sse•J a s w e l a o.:. ! . 3. 1 i t e r r r e tat 1 \J ri of sG' 1 G' ct 1'`I 1 t 7 a ri iJ skJ j L e f" tiL• 1 J Z ts i•• r 1 t P r A a lJ r, t// G _. ns / 1 E: c 1 i a ri 1sm 1..Z f V r SJ m G 1L t a 1J rl is r e Y 1 e w e Sf . 15 r e fer enc L' `.:.7 • ~ -~ /.7 1 , /„ , 'JQ4571 2 FRA1971-08b41 ~ Reiriforceaierit of alcot-koliscr: schedule control of >o2itarv driri'.:•icis. tieehri! .!. D. York Uriiversity arid Addiction Research Fouriuatiori. Toronto, Car{6Uz Cuarterly Journal of Studies on Alcohol 31(1):28-39, 1970. Larisilages: Eridlish A riel: rsoC ioio=i1Ca: aFi=rGacii to the PrGb3eGI of sOlltars drli/k'.n?. ..i o1cGh:=lii=f~ ~ lii=f~~ d erCrrcd to o= the Stlit/tJik15 -r'2si'or/~ e r/~e - i?1:1 Or CB(f.ent (SR.. :'aradl ;m 1s concerned with Zriteri=ersGrlal rather than irit.^ar'suc`i:c aria.'.sa:i::>< A::CorClng to the S'..•~} F'ar ad1aTf, the behavior of CLririr:.irim is aGi.~Ul r e{: ..:'i/... T,airitairied through the sFecific transactions ari individual h<:s with h.,.... en'. i r 1.rrlrrlFr{tsi I' affJ.Lk-I1 t i es erILLlVrlte r'e•J L•S'J the S(a) •rpr VaL11 lr/c lu••~ie the i cc/. of an arparerit 1Gc:a1 reirtfGrcerf/erit Gf the st1R{i•.j14Js to drink alorie/ and thc, fact that eVer} i=url2silmerit 17saj be antiiAilll3s if the dr1r1kIrio Dt='ila:.Vli:,r ...; reinforced when y t is F"urilsiied and riGt ra:.rlf.,"}r :=rd Wileri •b b is not PUr1:a"nhLd> ~. Positive social r'c'li/forceAierit Tlar PreG:.i=ltate Ci1..II ~ 'II•.1r1g bCl/ ~lO'Y'ior 0/1 ~. z. I ie~a ~at1''rC . `i/ i~ _r/t S, f .1t:1l '1ef G w11i 1 1 'L}~.•JtrOw13l J !J -?I7i 4reS:~ Ileti 'in a.. 'r! 1•..,.. ' -,.. iV~r'~..C~,C ~' f/i4: . ;a ~ -.c~~~,:..G~l si=eclflG "deFerider;ce" .."Srf alcohol i-ias been c~.sa:i`ir`~ ~e~lovlOr. r ~..l,"~ `- reilor{=+.r ated in huRians and rats7 this review addi•ice:i e::r-e'riifientisl i-heniJm:.li-. SUi=pGrtl ~.nS~1`..! ±- ~ draws iR.r-ilGatlCri'~ for the RiarcageT.ei.t ~.n the ! .~i'a~I~R.f ari•'J ~ <...!_, tr (-cat.iierit of a1G:ui+o11c';. 1 9 referenCes. ?
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ritrF~.._. .~....~,-•a.}s~>rT•.n... r !r'+•rr.aaTl~~~iT~err Ti'{L r L ,.rt ..,~ :~. .. t^v^.a.IT.,~r.f r;r T:..~..n~l nr.fTn-r\ i.~r•~. .. r•.r.. ~•_ .'rn~rC..._r_ .•Lr~.., . ~ v ,.r,_13 ° . .atClstsf~t._Jf`•; ...rr: ~.rrflVf.'.`v•r:~ri•TL.•rilLflr"'.,JV I rIi'V..r..f ~. ~.^± .i ~.'L.. a V r\ ..,.v V,JV .+ r. ._ _! t•-,r~.a~.nl.r/Tnr.><np._ ,r_,s.~•~ir.:.a.lnarnt._nr.rt 'r:jr v"`r;ri~..~..~. ..L~ .. • ~ 1!... +1:. ,-• 1 V f i C`TnTF4tQ. v /'i f v c•Lr+r,1Lr~,•.NaI;tt, r, ~ n ~; Yf. L•. . ;_'FiF..rf~F.I~ fr J ~I•+ ~ r_rv •..~. ^~ ~'~ :~i~^'fLi '.r1~ ?1E E;e~ILirvFL_ril< ~1I~ ~tE~} .'r~ a.~*. i' '-ilI~'i _L.. .. ._=~~t t.r : :~it 1~eo.t r~i~ f. . , ^vvT i'ic•.r_•!F.vUGi-. S }ilf. r,,lLl~I'1~'Y !"S.• !-.aTr~Jr• J7 r ~'/,, / llt r 30, f ~..-,_-_v J._ - ~ .` a r}I't^ V•y . llI[• LI ~ .D{Z{'a 4 ~fa1 f•('•J .' +-' _ ~• r. e 0: •'fC'a -~~iJ ,_:-'......- 2 - :tr~.lfLIt~1J "; ii~~~._„c ;. ~.r't _;f . ,_ cviS.ti.:. .i or- t' . CHAPT..~'..s_.' DRUGS tr T}ff .Ir~•.'r\r~i• T . ~•tJ`r~JnT+'vr,P'1tL Cc~f••'r_`r"rr1TIr_C t .4l1 fTrr" • .-ir'T ^r •r,,r f f~Fi''.~. L r~.. L.. 1 •4,4. r_ . .-. J r. a ~I. ..~. v. „1 .,ti i T. ~ '.,ti...,.. iJ..T • ...T IMf6L•~FiTAfsJtCr L T _ f L 'rr... ..~ ~t Tr^` MT~<'TNr F~ET~.. , ri-3nr,r;Ml-+r~^~! ~4"1,..T^nr,lL ~ ,,r•TTr.aSvr•. r,r_ r ,~ a, !r l~ f TtJYf,. r_~~.~°n~..,,L•_. ..r. . MT~Ta~•,LC TO ;/ ~ ,~o~,.J.~~rL'r. _ f ~.T T.-l FEJL ~ t'-~C• F,retnF•E.,r•TT.L^~r. ~ ARE ....~~ nr.r cn'Lrs'f .! ~':fr'T:T`f~.r FOR .. !.- CCCCi'TC OF .~'r'. V J ON L./~ 1 V r'ntL!ICC (•tlt t•~ L•Cf'~rltV1Tn{IZ• JVJ I!CT AS L.~ .L V r^ r V,TlF~/C•rr T L';Tn'L.Qaf^ 'Ir• vn.-. . •..-.Yt f . i r r. nl7vy r.r!!_`• ft~.na.rT r• .JTTa.:;rf r / I L•~ f J ... CAN " r~c~f~:.•r^VT LCIJ^rl"."a A Lr. L..< / I r.~ 1 L. Lf\a- . V 1 V f 1.L./ r BEHAVIOR r. L'TC1rr-qcatTlLv I \.i"/~I~rF r~'.lrFr•rrc~`"YT E'+"Iri^'~i'"r~:T^nrL avvr<L• 1 ~~'L. . t~l~ r / L•L / f.L ,... r ..- rr• MORSE ~rfF.•cc tii~ L•, ~Lr: • , L ~:'EL1 FL"ir. ~-~c~f.Y '.9r ~?i1 'Lc. L L•l._,~ IN Cci~lT Jf^ trfTCr I'ti1 L.'-_.'f.L.,. ' ";~cvFTrJ"r•qL -~~I.rif\.IL,• r•IC,n^CL. , .._ r 1-~trL L• vL !-L• 1! 4I. / L CF . r~•~I L . I 4•4.:. IN L•L_.f4rrr+~ IIC TfQr'L.•fr.~C'~rt~TC''~ THE T.f~r'nr•~r~?tCr l.rC L.r~`<tvtir'nt'eMrf "~TA+ r-,•^~rTnrP1rn T*t t~r_~"Grr,,~:*iar.x.kt'-:J . .rrL_ C,'TG•DL D L T.• •ENF'~ 1 L• 1 L• /. BEHAVIOR • t'`f Trr'//L•Gr.J• VL~ `• 1 I V IFr1T(~IVfTTnlVlf,7 ~ iyr~{ {n V.a~t YC: V J~ .r!G.fF r 1 r'A.•(`•T'n.J /n\r v T 1r• v . ^ _.r~I,~r•r~FFr~ f< T/f~J lL. .- L L• ~' .~ nr r.CT~1ttc~Vr.'•'r_r'^,..~''fT F'cF,..ATT''1r-V ' BEHAVIOR AND Cr'~'~r_r/7114rt ',~T nf'tr.lVl13 r T. '~J~..~,•,TTr''I~•. T ~. r,,M1Ln°...--.c V 1 ~,L..11 V L-r 1!t 1 . L .L / / r 1 V. aJ/ V/.a..L 1 L• JS.i a,•.tt• s. . ..~. THERE HAS DiV`L=PED A LARGE BODY OF LITEkATUF'E tL~•C• FULLY 1 ,J ~1,•L1vY TWO TJ~..!'Jrr^ y : L L 4 1 \ + I ._.U'~L.. ~ 27 n v. f.Yr ~ 'Hri-c•"`-i„~~4~`'n,Ln`J"it_ F:Ev I'IEI+:Si ' ~ J''Iffn'w.IT/~c T,In.T TF'c r w`nY IN ~ 1 .4".rlrT~4•f ,~ A Fi ..,:,,°,J;., •r•r.~' ~ 4l 4 Yff. f ../L_ fl l L•r:: uE` 1~•~L~• CAN ;+rrr•` rr•.rl*: BE r ^UD<L' rnAM fENTAL T l I r'•~.cTIT~r<Fr;3 HOW 1 ;. F.1 T ^:4si~rTf, r'OLC J L L.•rLffJ f~iy' stI.•• `~li, Ic ,.. •^ L_r~ . ~'f•rL /TLCf,.fl~ti. THE CONTROLLINO PO:rar'..", Oi- THE SCHEDULE QI_ REINFORCEMENT BECOifiES Lr"'..nr:El.:n'L.i_. EVTTr..~~.'T IN CTT`tnTTr+~Yt'rv V+f t~E['C• r•ir/i•I4t'- /.L eLL• L •• J .. 1L/.• Lt.-i~i nfL• ,_4CLr1~Trre LCr~Av 11Ii.ir' Ir n HlLTrr'r""I nts•l!~! TT!,'ri+~trlC"1L..' iL!. < Ji •A'r ia_J f.._ L•,'C A >;•7-CV AS r~r -rt. "~4iv I!Lr L f 1drf1.~li' bVttLh ~ I. ~1 t• T 1'~1 SUCH 1 1 I.l J,~ ^F4trt' •^ JTTV~r/TTn!~'.•tr•.'7, ! r"r1•C'- 13 • - !.1';~ i J .•1 1.L.v V 1 ~ t.l T!~.1f~.._ ... S:..tB:: i iiy'i rIYiL EViDEki^E THAT A SINGLE i i\i.iG CAN COi.liT lOL BEHAVIOR IN tiiFrEr.4N~. rtl ~t n 4f^r_'C~'tT'•r~lr^ ~ ON ~f THE 1r Cn~TlTTTrt~l:~ n Qf T ,T.~ J n CV^HrLL'~~.<nl_tfT~.ff T ~,<~'i... `~ t•.C:•~~~C JITLC. . WAYS J L r~'~.. L.I.L•~V.1Lt f.4:.1 , .~ rr.. C. . tf 'n REVIEW /e WILL I~EVELQF' THIS THEME U r .•~il .. , L4~r vfCL/ar Y . THE f p':_3CL;t.~1T /:~.~..,IAlG . ~ti 1-'~~s;;°:'. EXAMPLES RECENT STUDIES ON THE CONTROL OF BEHAVIOR BY NICOTINE ArJI' CDCaI..E: (24 refs. ) 10/?J9 0536293 SIMILARITIES IN REINFORCING AND DISCRIMINATIVE STIMULUS EFFECTS DIAZEF'AMq TRIAc'.QLAMi AND FENTQBAFiE;ITAL IN A'iI''f^cLS AND HUMANS ** '-;EjF:~`J:..3L',' AND NEUROBIOLOCY VOL. 13 BEHAVIORAL PHARMACOLOGY: THE CUCF:E";T .C:•TATV~..• GF:IFFITHS. Fi.k. i ATQFir Al.A. i LAh1B. R.J. i LUKACr S.E.: Fi,^,ACHFi .:.D. ~ T . r° I Vt?~TIY~. ~ ~f^~.-14tnQL OF M:. rI•r.. BAF ~TIMC'•LL,nLLr, / ..~, .!-~ ~2n4l3~ ~ ~'nV.}='.;•T.riJ .~~ r ALAN LT 1C J ~ I>~r• { ,tYL'~t Yn~F:'tr9 Il ~1Y tV,./ ! rt.r_, ~ 'Ti19 4JL ~'~% i 1'~r'1(] 7c. v T a 1 `t:•vf• C •1' /'C VrW V il r _64cy1_ `71c_~~; v V Lan3wo3es: ENGL I SF! Ilc;cu:.it .t Twr-c: LNAF'TE;: t f ! IRIr'n4`= JL r1 Lr.r f ~ I;~ ^ C'r'Eo r`Ef7, ~/ '~.~t`•Efi 'r ~J , f` TD REJ/IF~I F . SOME F.L~L 'Cf`C.:\.1T C'T~r} ~L1•~ 'T i'r:^~~ ;.C+ •-.~ i C'V Tfi ; f:T F. ira~n. STUDIES IN ANIMALS AND !-1UMAt+l,~'-~ ON THE REINFORCING AND D'3G4:IMINATI'-'':: STIMULUS f fIC C•F:OF'CLrf•, f THE L I r~l+lXT iDLYTT .GrIJL !^CI~af A7r'C•'\i1M, . ~r4A7d, i't.IT1 TT~CLC ~~ n 4rG TI~11•r.C .~r Tr L•T~nLL f Tr.T ~A7~Pi4L "t ,,..• ?'T •rA ~•`__.•T~;~~,L. T L~AT~, ~~ ON ~r THE RCL1 I ~'Thlf'1u DDnF'Er•• .• f' Qfr' G~tt.LIGtf, A7T?IC• L'.1'.1 _-' v r T3~1C'CSL...•t f.VTICLJ r•.r•t'.-r ~M,~.LYtL !f.. F~•.Ln BEEN ~n INCLUDED ±Frncrr Fr`I , 11+= c•/4t5/r•QoL_V ncc. ALI fTHRi.4r~ Irr. CL+•f~ nMr•1L_ETE L r t/- , ON ~ r n.f ._ I OF T4HE DRUGS f,L NOT ~. r, r` ~n 4MF'Af,nA,TI,.L . n .T:, _-- ^ 1fC P r~C'C 'nT fi1>,1~~r,T1L.ABLL1C'>• THE AVAILABLE C If'TCTC?I!~~•~,.'r.::. L P L~AfTA C J/U fQ! ~/ f` ~1 /_CLr+`• ,4 r ~n 4i`<~l~• Lf~4. ri~r4 THE r•/l -,~If•TMn nft ; flL. ^">•!L• !~114MH .,i~~ E~• '~ nr1•PAu`~r~'.•TIf4~1G i cTM r. iv.,r.!I:n"fl n cF'...°~,t:~.^TTn'.1:•,~ L,•.~in..'~'~ ..' r~fEr.•T iMrL+Y~„TJ ,ruL / _. BEHAVIORAL PHARMACOLOGICAL FtELATICN;,HIF'S. 1 ('•.C0 rz° :. ) ..0/,.r: G C534^''^. .,; "_L~ 't'n4.i~7 fri~` 'r>f'irIL•~• V~•f ^rnLnr•r9 f >.,<cLLr.~II 'Ir.'.,nTri''.n~'1t~JMTl fL.TTr4f'JY AND .~l~ i I+rlfl ~~~~ '•' J~~XUAL ' BEHAVIOR • Tf >,~ '.~nrir.iu'.i•~i,i`., f.. HANDBOOK OF BEHAVIORAL I NEUROBIOLOGY VOL. 7 F:EF'RDI,UGTIr:N MEYEF;Sv":s B.s.:' E'.'Er:ITTa f:.J. s M^LMrt.'-.Ss !;.C. c Lc•r.cr•r+t~ c E Ij •~1~ 'f cfe ~'T OF MEDICAL / ~'Hn nRy,l ;A,. nCLQG'f; UNTl,.L_..l f, tlC•r•fJ•TTV D r Jr_~ .. TM I . LL•i~L 'LEr V f I'ESS '%Ew fn nt•=y f. ~.1•f ~Il ,4rJ1 4r .98. ^ _3^,• •-.+r- tc'. ,.rVf~;:nc V . c~y ,~5, ..c ~ I~c'•Lr1 '~i.• ,:'~ •_• ; L.O/1.7tJGoL s• LIV VL Y S/-/ ri ~ v.''4riF.Tr•[ L• L~L1~riiEi i{L ~ - T.•~I•L'. • ~ I L 1~4 T'+f THT.. ~` CHn'.i ~'Tcr.•~•T WE L~ + THE .i 1 I I .L f 1 L- 'Ic rTr.:~'r~.':~SJ THr• F'',3`'J^TYL' E RLr•'a_ATIJ'r'SHI'' f:rTUE='?~ CEF:T;'iT.`i r IC141.' f, TP•APr~n_ VMT iT~. Tr_[`rJ/ t_• ~r ~X_. Lj fFnHtL TEHn tTC.r• ., A~, ~F L~ T ..f I •nltLTAc HnV•r,•,.td.n4.at."~!-(^. f ! r ~tL~J,TQ .. Cn 4i~ITF,4~lf~4 T'f..... KNOWLEDGE IN THIS FIELD HAS ACCUMULATED THROUGH EXF'ER?MENTS THAT H:^.I".';= ~^ Tu/1 r•T T~,~FL,ttr.~rv•E Tr,nff.~ry~Ir•JrTUnae r_•r.~n^r_r_rCr• Z:TIL.'TL~>=n r•r~cMj-r'~f'jL L•.J ; `L••ILCT~11~,~,rrLJ f 1 1 V.~. / \ V/ r ,~!. < / 1 4,~L~J V.-.J J L.L• V l rL • . r r r.. Clltrrllf•fL i[L.R:fVl.rfv i i.JTElI. TO LrNL'L'I\,.-.ITrll`Ilt HOW LII\LG,~'.~ CAN 1'E USED TO .Ii\VLVTjI!r'.~e... •cPcNT C•i C:fC'?jTq n,F c[•YilAt RrlanUTnP. 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V iies• c, L`~J-.v4 %aF r\L! r' ~ -~! 1 [' f H• S. CGNTINKE PR;NTI,tG7 .YES,'Nc,. 1J AL) - BC'L1 V - A- »rme'J J ['-Vr1_ -2i ~'~ .0~./ ~1ai,''-.i~.Ja -,V•-i' 1h r~Cs21~11..i1 'r Lri ~:]} l~21 •C... J ~y•.~ttt i ^y"- ~y L•1i ~•J.3, },;/•f l.• 20514-C14C. TI - RodIatlvr:: b2i7avlCrral Ir,P 11Cot:LoR3 in :3i'aCv-'. ~.~~r:!C?C)!'."~!~'``^ Sl - TV,~` •1 V.'Url''J .-,C - To.:ic~ ~o a _ i- .i ~ I 49, ~ T•q~o ~.: n n-'Si 193onr P299 rt::r•~r•. • 11) ~1 ~oa_ IICti. . ~7 .,~:' L.A - Eri; Ai - Since f•J+s.iJ r e s+"aC'? 7i1>jloria are likely to b:: b.:: s.7rid E.:irtii' _ F'rC3t2CtI'v'e stmo3e=i-ILt-'r e, a roteritlaliy a1gri1flLarit iis: i.r v..... Y adIatiCri. Tiie follo:.11ri5 behaviorai s1t!J3tloria ar C c dr i 2ssc~ .,! this Pap2r: 4) space radiations are mor2 effc,:tzva <-:t G2ir~c:"'v1orF ; 21 ' -! -•-'(Zioritr -~; L.: -ri o.- '•b -T•oL'..r-4, •~i`•-y'~k sr E' + vlL. rt' r•odivtiori-disr':Jptior;; (3) efforta to !r.itlv<•t2 disrupt.o-r dr11gs or 5{l:c21d1r1=: are rlot 53tlsfaCtOr''.j 3iid th2 dr iJ.» i=arn ti_ btha`''11 ra.: 1': ti7::I C Y and (4) si-aL@' and ralJlat:a ori'i rI'J'JGCr :, 2rir2=,.,...' coribirled rTia'_ L`2 sarfergiat.i::. TrZuS, future apa._C ti'avt-'l will ti: ... Ct2mariolrf3, c•,'..'.'Itlrl, i..:riie for b2ira'v'1Cra: tC3>I:aCaii:i:.il3tar ari7 W,i.•.~... t ie clr'c:,i7istorices C'io3 52eR: 1rtaCiririojJiitavie at f1r5tF 1=rEatl'vL ur'=r-1~,1Cc 1C•r4 of a4+2r1tlr i~J J 1Li ~ li=; ',,•..',: oiC 2::F'2rt152 SiL iu~J.~J~..ra ~ ~•C.L~ C.ii_ : s1rii11ar to d2maridIrfg situations Corif i'onte•.J WfoT'e• n~ n t,i ~ r+ 16lol , i~2ii8'v iGr',':~.'ri~Pi • riT < Eri`CT~+ .~ ; ~..ori,• ~itiDriir.Z WS!:ChC:1Csy.. _•:.nTATu ~r In>r! ~ccEr ,.Tv ; ,. Ea~llofos!!F'HA~i'Sr,r• ~CLCc~ r • tvr_a,.s.. .~~•~v ~ H:.?n+ari i •~~,_ ~:' ETIOLOGY ; F's5chomotor F'erforaiance/kAI!IATICN EEFECTS i C;adiatiori DosaSe i Radiation Protection f Review i EiC'v1eW, Ar ador,ilc s *Space Flight 6 Support, U.S. Gov't, Tton-F'.H.S. e ! AU - Aririau Z ; C:Jorr,c• :' AD - hepartaierit of Eri'viror;r,erital Health SCiences, Johns HLIpkiri=• J;iiversit5, School of Hygiene and Public Health, Baltimore; ;",n. TI - Mechariisr•is of riaiJroto:;icitj ar+d their relationshir' to br_`avicrci c hcc ri le'=• . ' ~ n SI - TIIXf•II~:°S; !~~6~r7u SO - To::icolo':yi VC+L. 49, IS: ?-3, 1°OSi F21?-25 !RFr: 71) LA - Eriz AP _ in trils rE'`:i2:.: _Cme i:f tile e'vlderii;.2 r2+atlri3 L•aiia'vluicil MH viter 3tioria induced b" 2 r12Uri:ito',:IC Cii2fi.icalsi lc:ad aC::tati c..r..! methyl merc:Jr_ is =r2sercted with ar: ItVelilrt t: ra.'•atc t,ie'_s;:_ cilari3es to the '•Ji{Oer lylrig r/eurol:Lt:iiun:Col Ri2Chun2:=rTr::a. in the Cc._.= of neonatal lead r-1.ilsiJrilri.a, t 12 r Cstilts of ti1e ear .<Ly Wi-ra'r1C•i...... _:.:JC125 «:2r 2 confounded Dy 2:;C2s31v2 lead .:CirrLi?rIf r uti~i~r_. r"c' s:J 1 t 1 rl =• i ri J ri a e rrI :J t r,L t i ori o f t r i c• P:J i- s. Sib3 i a.<'•} '2 ri t 3 t tidi C s .. ,, botii r sid2rft= arid morikeys ho've shCiWr1 tiiut bioaJd'iG'ni, cC.lr{C'2ritr'atiCrii s curT/p-:raiC+i'2 to those seen in chll•.~~r 2rr C..-•, 1rIG..,c•_ 5t i 1G'v i i:, r.- . C-1 te r ot I far{3 that :+ia n be rei atG"~,Ji to r I i i =~ vi. ai:ii' al r +.iG:c.._ v ::c thc c==•2 of ir.2t(i,l r+i2rCUr'3 Whlcii 1s a+=3terlw i^.!ai :ta'.:iC o:=.c:iLi r eriutal 2::i==s:r'2 r23uit5 in w.: d2ar r2a•.'{i Cortl ='al i oii•.'.r .:ar l=bcll... , .3lteratiois ihcr a4tCr i: 2d .:•y rcdiJC2`.: rr,y21.'.rfstIVrii d`''io _s~.., iSiiar•vFs.ii=iri arid l:Ja= of r{2Uroria. These fi,Cri-ii:Jias1C'al : lt2:"a.tii=il"i'.:: crc ocCClC.=ariied by Fer7iarierit alt2ratlCriS in lc•3rriirio 3r1d R,2ms:r'... a_ well as alt2rcd r=iror TiacGl.a3ii.:al scrralt:V it'.d 0, ca+.,ei=rio.laiiiiric'r=,s.l= :7'»t2R,a. RccCiTrm2ridatl.riila are maCc for b-ttar .ci:irmulCu=d w+'c'haviUraa and lr2ur ob:LologI::al aasa'j= .'ii riior'otc::iCC:lu=,1 in Cr d2r to lead to a bC"tt2r iJifd2rstCsnd:rr.3 : r W~ ,I;i+ .•1 ~ ~ir ' 'r -`t^ ~_.z:-.~- t=: « - »rl ima l F Beha'v .. 3pF i-ir11 iSial l*DF.uG EFFECTS 7 F2tu3;'iRUC E:"rECTS , LCG'v Pili_zniira/*i': YSICPATE"j0L0r.r3Y r iiet.i•iaIBif'r c:Jrn CoTie'Otir1'~r=•!' TnYTrTTV 1 a.=rw_..,= Q'-=fcr..!*rt:•!In, FCCCf^T^ 2 O-+. .. 0-. _ . ..
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.O, ~,'?"TT`.r. , in• ". iT•r~,'it~"._ ~, . }, ~ • .`•~r..c. . ~r«.. u• L ~r/ , ~`' ~ , . P F' ROE : SS 17 l[:" :1SEF:= F•c'T r'i COx'r.•R <... :,Tr .. F'F;^C; io ~ ~ ~ .~.• s .i I .... •~ . i,:. AU - r'r= -C~ ~~ i ! + Li i•.= r s tin.'.c~~ .r-.=r T's ; . i' i.7,.. r r•rr r\ ~: ~Zi.• ~ ~ ' r ~•iv.JTi.,. . r . . •_ r P - r='~.C=FL ic:~_ ,";~ri- ~ - i-- 1- ..• v, -:•?i" i' ~`' . Y <_ ~.,i. •iE ,.;.^ ! r v ru•_t it't:, . , t.r . iZD "- .r..c:ice r The• ra=y E'Jalua t,iOi i r`i'JArsi mP Nati onal .r••ant: a r Inaj i tot... . BC'i.ire¢::a1 ME 20692. TI - Hr'3L11'.v=vl-w-c..'.c.L'3ti.ialiie: a iiJ`:ei iiuCi20a::2 [?nL..cr..r.i{ ,' l...r.=i_l t 'lc:: : .CiI ' Tvrl.^. aE/38. i3^~`v6~• ~2 cQ - 1-i i'':Csv : t .f:'w • ~ y .1iJ~ -; YL• finf,_ _ vP I,n)J r 4! 1707, 'i . J .~ •_ e • ,~ ~.vir.-•~.~v '..~\r•,f•r. --'r s.•. ~i L:; - Er.a; F~.,6 ._ t• "r+'.c:iiiV -a'~ ~ : i -~•- -s.- -o-.:'=~1o:~~ a ~i2W ,_ ..:.i~Tri=v+.1..: w~_ il _ - `_r_-:=_,_ ..- . :~~~ic2 is ..ii , _ r,.... .'. :_ e i c•(= ve d Gy the Div:n si oe i of :.ai ii._ e r- i r-ea l.Iiiei/ v Y r'fot:..+i.al C..i i+_ w1 .: nsl• 1+i. ti Ve for :_ i i i i.1. t_a.{. deve l lJ r u'i C i i v as a i 1 anv i i 1 C s.! pi.n .-• tA' 1_, a r C i f 1i bca?d an 1 vs iiish decree Of ait.iL'it.'d o:lolii:it a ..'o<3d ,:.nsc ii . i.•u?iGr ,.'3pes aii rrt-~cI:itl,=ai Stud1eS. Theraietit.:..: act.'r1t_ has tz,.. o:)sei"Ved ,:.-7alifav iiiui lir2 aifG irUman i2i.:k2m1: >> ti unLrli•nt.o:_ s.~ i1/'_i i J. ii C^•' sV.,i 1d i• 'J .i: orsP Q i/ d f 1 i.J //• ,? // ;i. SJ mIJ l' "C i1 V:1 e J i tB6 i:rablnvayi"-,r-..;.....cw,.i.15:.1'ie exhibited a d'r Vci•..ier s!•Ccf.r JT• V+~ ,>>o1~i= t ~i~~Cic-~i solid f.~.ii.i~7Ta ~"s„tan cyto31n2 urahInu:ildci:. ..."3bIiiaSy.-5-c1:cC_tJs:ii'c' 25 Fhvai'il:Ji-SIa+i,wd to the nU::.c:.:vl0: iL''.21 •-_ :~ -E•~c -)::_:._ ~ .{~..•J ~ine i:.:.;ia~l3..;ia~l3. vr . _er _u..~ •_ _..1~ai.~ f 7 ._ : i?~_,~~i f;~i~i, ,~,iu. .~.. 1ai.~ f7 . f. ,..~ !. ,,.. tI l i- h::) a i= i/ a;i. e la`.' 2: 7 1 t caii be i ni= D r r-ar a v c•.J .. ii +i. ,:i DNn. Ti", i:: mC.'L.l:aili_.., Vf ..'JviJVl./i,aL..Vy 17 V,74JSVs/IV li1J L•r relOVC'J VV ..il,.ar•AIF.•..v.. of DNR »ii;:.ilea:a. Lei1%.eTi1C' afcd solid tiJ7.iZr C2T2 i:.:re3 t.ilat ai':.: i e51stafit to i:avCalrie arailii..7slde due to deletion of dfCC::vC'wf.ldlrir= k:.iiase activity are .:.r'Gta:: ri:nlavirrit't i-C ar aC1:.'iv5»-..A-a:aCwt."5lrie. u Unlike cw+i.0s1i1c i•I'ahin0sldi::, arabinOSSZ-5-a: aCatOSlife dDeS not read113 urfdt'riG di?ali,IriatiUii« Schedule depeif•.~~'c•i1CC has beei'i deTiOnSt.rai.eJ in iA1Ci• Lourlng L12.ii:.%` leisl.eRiiao with a41p2rior actiVit.S seen with R.L11ti:"le do=;["_:~ admlniStered Orc each treatment day C07.pared t•O admiiin sa•ratlon t„ lar Aer biJtt less f r eaiJeiitin ad7iii{ISt.ered dC3n.:'5• FrC3Bi i'r2ilAilifc i":_ dc.,a in r ati i 1d tumv r i i4.1 C' as7 hviie'v a r 7 ai i v i t:.:iTr::r i .:rt1 w ato d+d d ..... _ a:"-'p2ar to D2 superior W1~'•..if cOii'tliiuGus ::ilflla%oC•i camrorc•..i to ..hL.. :.i aCrVc'•] '1 . . SL:~5., ~C` : -~.~! . .•~Ta'C~• F•r~C._ 1;-i fi~i'~o1 :. + :. .. . ~~J.:a'~ 3~. -.G~ ,v~•~3. ~~ir a •~a.. •.. -... , :..1..~_ ~•i i: _. ..d i 1di t_ L: L'G •J v 1 i O V L• / t e G- V`i e /il O r 1' ow and l(;) sSL 1o1n;• L:• \+ 1 1 113 ,. v rzV v ~•. L.... :-t•lE Tic`•si: +,z• .=ci. or zaic5. r1 =1i:= it' :.:.wc dLr= . of ar'abrilJa':i-5-as'.acldv/rslna f=i:1uld 1:•o t,U:a e'atiC.•.'~j b_ .L.•G:•..h uri.:.a ,..., ~ 1 s[.i"::. W~iei c~~~iil'ii=•,2^e;~ os G+=0ntlii:..iOui; 1nf:.Sa:.C.nP f.hc a-a rei 'a v t~~d +0 L•ov~i 4v' ~i .i ~=r ~ ~-s2 ar{ - d .., jJ.•.• ....: rut1,:.t•i Cf eai-oa+:i c, su:.lcaL_.,,.... L;at tO::lsi vy resul ted f i'[j{if a G i'1f.1Lal vi7.e above a t.hT`i_ siisi .! ,+;1-V _ _ _ _Q iJ .61. ~I C L ~i111_Cf 1v1 --'s - 1.J-r~~'-f~-L~3C'• -~J to the l y itJv01 .:ir~L'•~ i J1~ T L•.;~ ci.ri iV:.:"ii l. r ati i.iii- ti°{C' cur'•i ?. F•'.ia.ae T 4: i i:i11::. e v rl:i.i a have s_. _.,i iiil v..ated to CleterT:at'ic tiie ir,+o:;iR.Liiim t•:1ic: rut.i?d dose a-f aluw &_. _,. .:Oi{f.11 {fJ1_~ -•J'= - n nfuaioii schedule for 72 iiv;.ir -:a and a.:a.z an a L,:=.at di__.... short iiifu=•iGn dai lo t:mES f°.'ve = Ch•:•:il.? c'. r*Tiirrli.r.r JTTC 1~~~,... Hn:i'vi rai Fi:.e(`if.;/*THritA~•E~ TiC i ,~J~ nr' P i- n ~<6'.V1'1 ..il-iCi . ~. !~ . i H'l man S F, evi ew P F. e v i t' w S T ui. oT i a i 15) :iU - 'vCe{oce=: i V D - r ' ' . •:.; l:~c.-.~7~•?yA= r•i..~ Pr.. ..~P `•e=Sei9 4 •w zc'ii::,i-4+=;s TI - C'_,••r..ent._ o:i the a=_•es=_.,ie,,t af ..,.urzt,.,.icit... ..•n routir.e to,... ;,.
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T,,1 . -. 7 , ~vvi ic~~. I•`Wr't~ 1~~ TI~ I~,!r ;tIf ~ TI~' :• ^S,~~I~, ...r.~• .^ ~ ~ ~• , G- ~ ~• irl li - T i i= o r; W, Ai - La bor a t i.! ry =+ f Baii a V i l.1 r:3 i a ir i.f N'C' ur iV I ul:. i_ .a : T:.o :: i c o lol':.: 7 N:3 ; i zha.'.. I r{ stj i-`JtG 1.J f E.ri vZ riJrtr.ler {taI IltO i t/ / ..JI.. i ei•{l. C a l 71G JC.~O r 1_ 1/ T r i0+1i...._ Pork! Nv • TI - Behavioral indices of rieurOta:':icity: :•:hat Ca;/ "o , A"Y~~??n CT - T!9V'••iBr!p~.•+? ~i!y:.. V 4• a a ~ / un 30 - NC` {J r atr V:. 1 L oI / e r O}1. V 1 ; !V! 1•J L• 7 q I J S {J t 1907, r• ;2jt . 7 7 (R1'r r•' : i. i• L. LA - Er;2~ rYB ' The ,3L+l.:i}i.y to i+Jeritafy arid ciiarac{•er:.ti.: the P::it.?ritiul n:=urvai,t.ii;lclt'j of ciieCii.:.als is an .ir/;r-i:rrtai/t aiid rie4a5sary fu. _t:i.o;-. i.3f V a'' i oU s re=,;Jlato ry a=,er11_ i ess PCiiav i o rai a:r se 77mer;t i l:if :.•V:.ii:it_ i..,.._ be i//ii-ortant because of :'.h::7r r/?lativE` sc•e'i=•ii.i .~-t... to =o/i,e 1=i ieG`i i Cai sq ji.he i r 5er{era i iy riorii ri'v'i n:a v:7 c/ia r act2r i S ti 1...-. . 0;,d v, ie j. 0;.. .. i i ty to ineO~+{.j re toi: i L a t'3 j ri lJ rgar1 s:>j tF-"m s. i-+ t: ie r t,,... :, -uhe nervous s'Cs{eni• :eha'v:.oral testa i.ari 1e i..ia:»ifi.t:d i+'.> >+iver._i hri t G' r i O i i 1 1•. iu'J i r; j t ra•J i t 1 1J r{ O I e i. pe r imC• r{ t O I Ue( i i 1! t i 1J rl s, t L; k.' .r. r dr==ire•:i '-Ai=erImarftal usaleq the rieurobelio°r'i.:ir<:cl functions ±hc._ .=re desilr;ed to a:r525s, arid the Str aiesy L io5i?r+ for the?. 1 w_a .. 4i'ie evaluation of che7;:.cais. E:Sa'ipies of r/2{Jrob2 /+3'vior0'l ;t'-:1..:.. UBed to evaluate the effects of cc{eT.icals for t.:i;:is..t_ irl.:l..._.._ t;-l. :e that evaluate Riotor (SForitar;eiavn T,o+•:•r uct:\'v.'• t:iq :/4:,oti coordination, :.:2akitc'ssq abr;orr,al mi,'veT,erit or r-ust{.tr eq trali.irrY Gir,-~.--"Oiri= Fei-f:+riLaiice)q aer/5or s n acrc•erlir/iv refit•.. ,iiodiFi4•= tiGn. i=ri•.'{~ .Iristr:J°ictrite•i Cori•."tiltiCiriiria)q loarnirlgi TIeAi: r'd i-?•fld uSSoclatl'veJq IreStrur,ierital PerforA;.'.r{cE (schedules v"F reiriforcer/;ertt) q artd r;atiJrall`.i occUrr:.rc:3 rCfTroriSes LcarlS:Jr,ItS;ato1._ .=ehaviors?. Behavioral Proce+jvrea have a'sn beeri utilized i;{ Sialect LlaSS in to::icological research tc detect latent damalao tC, =>t{Jdy mecrlariiS/ii5 of actiorl7 arld to Screeri for fUr/ctioiicil CjyS'ciJrict.or{ followirig exposure durirtS` da: VC?I.:•p{i;erit. Mari':i :.ori5lder atioriSq such as the behavioral ff,ec-ilc:.rt?,SiT/ of cit:t:a+:ii•ir defiriitiori of an adverse effect, ProbIea: of furict?ur/aI reaerve i ariJ SeVer al StatiStical CiUestloriSq should br ti,•i'.eri ;.rtt.,~ ai:i=s..,At iri the lU 7'c' c+-{d :n rite rpr'c2tat i orl of +Ja ta oi1+-i., i r/2 .Jl fr Ci17i t+eha'v i J+•si. tesZ..=•.-. D•J •r.Iri3 ,/ ' ~L._ - , .aosl Jeca+..l J2/ Ie tLerB 6 la`vi- G 'i?c_ 1 . l1/{ riuT.crt:iuf; iccGCiR/er1~~o~ :~ t ris~oJ• ~: r,•!I•' the ...~ 1!~-.I/iie ~ _.I. ~tris 1 p~iR; ai~'tir-~ Wl~ilirl ~ r• ,~1. ,:3~•e:_ - u/_ /i,J •q ^,G:,,: r c' c e ri i• l'7 q t 1 1e woi' I v ;'! e a.,i t i-i V rsa ri 2 za t i o r i; S{.J Aj(? ;- t i r i a t i i i> t- O 5 teR4at i L oLi 5e r'v'a v i...ria l a JSe ssmerit 6 u•an L•e .a!-r i' V i- ra aa•e ::ii..i r f arricd oUt .:ith:.', ai e'ea•,'q~S ertistlrig ta::i: ol:>j:rcal i-r1:•a-ri".:ii =. f{ r! - i•1 rt ima l I Bi' ha v i o r i? i i•~ J V Er C E 4. T S 7 IN uiJ a r/ 7 7`! ? i' •v' ou`.7 J'..: st eiT; Di-v c asL._ . *CHEMICALLY INhJCEB; F'SYCNCLQGY q' Review +Reviewr Tutori,_./ ,a . ,_I ALJ - Mailr,{ar1 F;S AD _ ~'-c'F'dr+ 4iic/_!+~v / , - :~° cs_ .4ya-+r'd ari1J /! ~ _.`arlua.- , "_i'vc•._:J:. . ,e~•~. ~ v/ ~ '_ t a.•_,i= .._:a..i~~:ir i~/lr,.11 C.ir:7liria ."-ii=L;.=•ol of Mad1,'Iriei G/iarrel Hlil. TI - Mechanisms of CNS irivurn iri behavioral •.JioV•f;.r{f:tionr SI ~ TL`:BI Bi,VS/J427v•• C - N6ur ::~1 . o i ;:.CO ~'CO1 ~ 1 - •~o~. 1! .~ • !!1i!.- !7r Ia <+:7 r 5, 1 .. G 4.\i,'^_ r ;/1.r,r•r. • r_~~n'•, :~+ 1.oi;:. CO~T2i-onn~,.'^; `:. ~,• _.. . LA - Er,=., S+.i FiG - ttvai;Ce= irf t;;c ria+.lriV__ierfces Ilavp Ld•.~d to Ogr votci ,f the Cr.aI7 L+io~:1/ _•_c ,i a/ i _•J J ,Ci_ti.a , ,li._i i_ ~ L •J/~~i_~+' ~. .~ai //+:!.i..~i .: / w i i 1'v cd .. ;i ~ ~~11 . ../ i'` 'i'tr{~J1J1= vtJi .i,,IJ aJ!1/-V O V 1~J1/ Vfy t1(C 1-C-/;+ 1' trO 1 rfC 1 w V1J'~ ..:~ ~ Vl. • n 1'. 1~ ~_C:~csc3rch has Ferriittci +J i+ the elucidation G'i• f-ha idr=Chariisifl-• fUi__...._ /1_ uratl-lwi L urft= :vi /ose uL t i Vri= iia'v e i_iC'Gr/ j F.uJi. i. J f or +.•ia-cpdt: sq as .e. i, the t':.au;i-1e of the P'=rCt//rozd i1{jectla.iJes• Ii{ cVII..rOstl l•,/,1 sCI L/ i C! f 1z,r tJ f sha nC'J r.- V IJ n1 l_ i vy tJ f t1/ C o rzl`r 1 o r1_/ V O i 1, t1 W. ._. . . & . , n . ,= c _ = a = '-t = c , , - !.r -r, , • r. 4 .-. ,• ... -. -. , , i . , .
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,,~: ,. .: ~ r~ r: .f^ 06434234 ~ J1.e i ? 2J`/ L• t1 mmC^/ := L r t r. e 3ssCssmC f/ t G f I/ eur V t Vxl l 1 Vs in ro•J v1 -:~..a:1t> > -`.•= ~.~. -' ~/2 ~•~ V L I l a t. r r' 1 U L . v.:.~0-~~2ig~o r-iG't BG=,=. 1 .:w1tzerla/1U• ...•~ .-r•. .Mw~r>,r .Y~ v.r_n . ~ Zer{ raT 7~~ ._,.. _ -.Lt_,io.. 1 hik.rc~lia.~.ia. ~ Fi•3s . C4'1 ~ Cn~r_r , Ir^UT! n ~ ~ ,,t ~ ~. 0? . (1-2) _ti _ .: . ~ J_.L• I L. ~^ .-t ~ VcL ~.[ ~c,.. L•i,rrio c•~e. 1~J Larsvag2= : E NGLI3,-I NetJrOto::ic:t`= G4cur_ 7::ririg admli.istratlon of higii doae5 of C:..i'I:Jur.d=i testins for acute to::icity !Lh50} or ar{ ;;cca:- i o,-, of subchrcniL trestr, ti.MfOr 3=•5es=r,.ant .: f uraam tG;:Iclty. Naurvt+:J::icit':3 :.'iduce.i b2ha•r'1G1 ._ ;. Q 1 r•3 tur L• a r{ c Csi {.1 s'J a.i. ly f 1 rst ri {../ yiL 2 J l• 'a t/_i e ai/iI,i a? 1= ls ra V O n. c r s. :I r r iV ... t a.. V L ser'V 1 rl j •.l G 1 l'J t rl e G^{ 1 Irf O 1'J t"L• st e J !a ` L•J r J 1/ Ig t o O•..d th4./ r A. .L e•.J .3 a1•J C.a .. r r_. ._. . DUrirlg the f:J1lC:...n=. I"ievrllUllC'al e'.;aifii'iatllJrf .a few of ti1:. 2::.rssL: an:irc•l.... ..,.hibitlris disti^ct Weha'viorai diattJrb..'ncesr are cOm=r]rFd with ,=orrtrc,..... The rfeUrCZl,:i Iccl e;:cm:.:{ativrt Scrrves to charactcr . e the observed C'ilair5c.- whlle the =fb=2i'Vatioii of the whole gr GiJi- of ai1lT.als .:r the ti.vTl.e caac> >iV._.v 1 r{ di C. a t 1 w r r= .7 bt_• 'J t t l{ t i{ 1lI i est nV i I--t J i. 1 c •.J iJ s'•L~ ls'J p,• r{J r t r i e r t ti sts f... . 3r3u1•tlOric`cl clarlflt=atlOri vf iitturatOr:lc:.ty w7uld Ge evaluation of spontaneous actlvat•3 in the r=i/Ot•.^rcell"raler hehavl.ir in tiie 7{a.:ic or oser...0, behc•Vioe^9 tT•eas•Jremerct of the 6rai:ifP+uR• nerve cOnd{Jctl:ln •veloclt`_ or oths; esreci*ali= de've'1 cr;-ed tests. (6 F;efs. } o:,,;= , v„480329 88125329 ieila'vlur c;l i= icrrrai=OlQ d of Rrlifl3r tranC+i.lill:•e1 s. 1. le JE: F'G l1c:. S hF:C P1eurupharr:iacOll`!ov Research .r1rOUp, School of F'harracsY tlrliverslt3 Loridan, U.K. F'haraiacol Ther (ENGLAND) 1987, 35 (3) P2L5'9JY I::::N 0.'•.63-7250 Journal Godc : F'4 ^ .. G rr~iJa3es.. Grr~iJa3es. "IGLIBF! (237 Refs.) r.' 9l7'1Ci 06470234 88115.3; Behavioral F'harTracOl+7 :j' of cocaii'ie. e-iSchmarF W- ~ ..~%3i•'orti:e it vf ~'s'i:y i.atr= orl•.t Behavioral 3Ciciii Gs. jo;-in3 Ho.'-r•.:...... ;Ji f;'vi_rsi t f t~' q(_-L,i_•iJ. ~ o u?•~ ,1ci pO1tili/CitCr MD 2120S. ~~ ~/ 1 r~ iC9 p i Ci;a ~ G- . 1r•~ •~~ /I taTT. vT^TJ ~C} ~ r~~..• 2, l?n, 4! ~rpi ~ F?-_~~,;, ._~.. ~'c' ~iic. C..'1 • ~nJ.,n r J•.~ i'-~ r• >: . ~.iTr Q1L!tn_6V1c~~ J1 -.~a r•_L••J~t.'Y a L• 'v V! \~•Jr1/C• V Lartg'.Jages: ENGLISH LabDrat 1r y da{•.,a =ugg2st t71ot on1ST.al> >alf'a•.~~:Sil:{l::at2r cGcaln2 in ^attc;•..:r siCfi•lar t0 tlic•se 5cc`'ri in huR.or/s. vvilditlG+is Of o'va1Z.3ti:l1t'c aii'1. SpCi_ic-n Orelatively unirr„ortar:t raterr.+irranta uf L; cair{e FiJr'ti"iertTiQrel studies have shown that ai.l7lala will c::vrlt.liive t.:. self-admiri:.ster ti-4e dvU=7 eVeii in ti'ie fac+: of a2'v2r'2 t.}::Ic 3.i da eff Ci=a_'. - T/ l e S J a t•3 1nJ Jca te t ha t co1e a 1 r{ e 1 3 a f i J te1{ t r eii{ f V r cC r wit h s. !r/ 1 f 1c..: r i!. c3biJse lla'C11llt'_. The a'iimal aelf_adi.rlniatrc.t:.~ii T/I:.dr=l ai{d labUrauory 1.'{.... coricerri.r{> ;e.f--ac,•.iriistratiori in hvrr,aris show crUss-Sr-eci.r- ."'•erlyrr=.l..tv F'rovl7e Jsefu.. 1rifGrmotlCn abvilt COtali{e`s L'•oi"iovi.Gr<3l 'YCci''n1.aR75 uf .3ci..1..n. (19 F:efs.? 9/7/11 06465151 33111151 i ii1 r= l i c _ t iG(•i = l7 f t i`i'? cllfilcai nrier{s EJ Tnst i t{J t C Netrierlands. of rieS.et=t of st?r21. 'i IT.lstr'd in F'harmacOlOg':7 .3rid T1J):lsGIC'.•AwY Uiii'ver'ilt: of Nlvmc'x=rr7 a'r'{1l Irit2ll Clirr Phar;r. iS.C.rI' e._~ ,, v'vi._'-uc~L r,i'-uc~L ..ilryurre[' 'it i • • • re['i LO•i iguGgC s• ENL/._ i tiI-{ {"'/1 i l' `J l• ..i ir/ e i r s1•v e// 'i"rIrrrl STATES) ^t . t yr'°-'f 21 ..~ . r' _ ~'y., ^r':- (ve / ~ u L. i. Codt.' : EPv 11 I ailri=il.=aviVrls If
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/;c'L='c' =at•_ to r?iot2 dr•Jg effects to e::'i-r'riii/eiita:.'.'J i.'Firi,__r . a.>r a,.`.ieS Pa-jii?~r ti1~,~1/ tv Z/.•OJJ ~"•..OvC'•J J LV//.~l .l.Vs rC.J 'a-,-Va-~•J .-• ., r ~ L ~+~J_ l• . C' e'_• 'r-' r;± O a';. S,= i e r/ t i f ic i- 'S '1 l=' il Glt:i g'.3 . T; i e v.J r• i,3 bi i:. ts u f dr _. .... crfrCGt•S rSn1=Grdi:l : to the hiii J of Llel/a'vliJ r r.=eii1g i.Ji/S i•G: r'ad. ~i.._.., led tithc' .:o:,zc•F't of ..r IJ.a-.r'•/eiiav..Dr' interaG:'.aGi;. Behav.avr be tr'eat_d i:/ P_•3chor`;arr+acolo:3ica1 research nUt• i;;;sn a:. 3 :12:i=er7dG'iit b'Gr .ic:bleY L1uLY Cveiittiaii':ii aD an iiide/=eil'•.}eirt ''rar .:<_•bi.vl. Tr c••-ii ,;ilst-;al arr' roacheS to behaviGral Phar macGil:rl:3 v:.ew[i.:'. •.IeiSaViGra: ti%ar;l'?s a: coriSeV.tuer/GeS of jJP-/Jr ri':iiriS r-iiy-in1V:31c13i t.,- T - ...OGia':-1:=cl c~l.;iio.eS. in 5;7R;2 CoS2S7 it 52e/Tr:3 ti/a'it r.'.•rt v,` ?,:...s t:ffe_tS observed at behavioral ie'v'tlS arC to ie c':,r'la:.:7a•.'~ bb trl,.. int2rferer;ce Gf ;i=eCif:.Ga11_ bCrha'v':.i1ra1 Va:•r.La3Lle:3i :r, in vWi:.: terIT=•S iw the ='ec%Jliar reiatiGi;= b,-}:•ie?r; the :+rgaili:am aird ...::_, F?'i'i'v'lroi/RiL-~rit. -~rit. SGme tyF'Ii:al 'rT'iJL1eR7`3 roiScJ r'lii a. ;:•$iici'iiUi:iii ui-i3ZsS1=Y in the fl2id Gf tGlc'ru:ire uif•.'{~ Gf G::i-eriAleiit.c:l.i ..i,dU:...../ G Jdj C 4 L'b! i 1 } C• / t J i s\. •J => sC IJ . Mii - r1 r{ :a ma i ; i e il a'v 1 G rp A ~-.,/.•sf~.JC CTS`/C•iYo~ r/iT;a.,/.k,.,~ E,ri-r•C 1~, r ~ I0L0Gai ; Dru... Ii;te raC't j 1.Jif S 9 Dr'Jg Toie rOr1ce y EI1g11 s/{ Hi•.st r6ct / H•JIT,Gi; . PsuchGtr'apic Or%Jgs.'*FHAItiMACCLOGY i Review ; Rrview, Acadea,ii Substance Depe,i der;ce.'F`NYSIOPATHO:.OGY r,/TT!( C F'F:,,;I. r, .:•: T,;I ~+ !;": ( V`S;ir.ir~} ,,~. ~ TT .r,.:•: ~.. USER • . PF:OG e 9 ^ a ~ i^1 U - G'-: e{_I i C• r t TW ; He."i 1 1,...v - F,C % J;.:i': i /'\ HL` - F. ;-{ VffI;i?r {r i'1.-Q Roche Q C6) . V.td.y Bl• se1 1 v W i Vzpr 141Ij. TI - Overview on the rt-carr,lacGi;ir%etiCS of teriO::i::a3Ri. SI - TOXF:IPlBSI:9b10fi SO - Eur ,1 Rrie%JC,atGl Ir;flaRirt;, VOL 9s ISS 2, 19°?: f15 .^_5 (Ft,'"F: it) LA - Eris AB - TeriG:CiCa6if a new rlGrt-SterCidal anti infla3m{Yiat-ary 4;rtJ; !N.-~AID; with an G`.acatii Str+Jct%Jref is r2ritirel'.d iDri]SeCt .:•t rNo i3a5 rfifiii/ta2 lii=GrriZiliC PrGi-ertieSS il] nii rlasma PrGtEi':i :1iridiiizf does not aCC%JIiiUlate in fa:tty tiS:rLiC and skin an•.'~~ th%Ji:, has a SRIa1i vGluide of di5tribUtiGii. TerIG:i7:.aiA in rapidiy cGCii=letely ati/=Gr L7ed aFter t7r al a di,i:.iil5trat:..:.ri. I+„ 1S ent: r i1:.. aiE3tobGiiS2a .ia o::1Gatioi"i a:i•J Ca7i/,1WALt:{+':, ratr"fi•iu» befGrc a.:iiCi:.aatio:i. The e::traCtiuri ratio in the 1AV2r i> >Arali raSuit•.i.n_., in a:Jito 2:iml:i•3tili(7 half-l:.fc wit•h o iSi,?a:i ::.r 72 hV.•ir.S. si:ic,= .,_ .J/iChallgeC{i drlJC: ix found in the bile tiiv 17w rialf_1if? L.jii,_/v -i ._ ,.. k2::i iaiiled D3 cater'l`IilaF-at..C reG1rC%Ji,.:ia.lcJii of r-arC-'rit G>^•tLrQ1Jr.d. ,,.a.. low eiitLii'iatioii r at•e of teriG::iGi.ili al1.ib1S FJr a ijnLe-Wi1S d::•Sc:::it: 020 //r _: ) re: i me:i . Fr7 1l"..1 w i r+g (i. U itZ i= : C WS i rr : dli r 1 r.! the f i r_ t ,. •s .., :a%eek'n vf t•cier,=r•3 taiiG:;iGaT, reaches >taad'3 Sta3te ii1'vs.in wi:'.ii::./ ..r"2... CIf r rc^'d.1 t= te d •v'oiueS. S2Ve r ai rha rm a.::.i;3•iittl.= ra:i:tvrS ilL..l.D mok_' ae! 1 1_ ...L i4 a= rTr t i-I GJ r,_ r- ;, S a~j fe a i i L st r 8 jlI/ t f L/ r- V{ tJ r•J • 1 t is L V iTe r- y,- y a.. ... ._ a:Ct_•Gryed when tc+ke:; ur'aiiS even wita ?real:a or aritaCidSI K1. Ptn'c'tr3tt-'S eC• _• i i'= ..o i Li.i S`,j(-ioV' i a i f iua•.j J aifi) :. . Gi:i_ r'Ct+=d i.:i.. i f/ a 1- t1•i Y // i et C• L• \J l L t es. C iJ r t L e r 11/ V r e/ J rJ%g J! ~~ s^r J.1iti-,.!1 t .~ • s i%ifil.;e{-iGa& :.+y a:t=Y S2i•. or r i-{e%Jr:iat:.G disease ar;•.'~i %Jr{c:.=21 i.•ed _- iiG oCcu'iu:ativri i t observed. '•• • - A'-+%J j t ; A3er ; ^sC d/ 80 Gi {IJ o'v C r 3 Ar7t A-.TI. nf l alTrmdt l/ r.3 f'/lC i 1{. _/ n%.-..IJ~./ r.-•J~a.e/lJ1 1• / 1~ 11JJ .G1!•~C•1.}~R{~ P(^1v(11~'T~r(II~TTf'Fa I'r%J •:1 -t7// .J1_ -~IC _ r Ny( li"•~ V/\ i ..,. 1 1 1v J y .'J ~J!Iijr;1 ~,r<~t.LdIJ 1 a.. . ,.ir+JS ;riteractioriv ', H•:'mc•ii i ti .i•J''ii2w r•,aSCa:-•iJ -:yi1 ij~~ / "'SCTAr"'IJ"x., i1 . Pi rG•• ''ic':m;'*i-iN:iLOG`~ S nrRI• L/ATT1r1EC/F'/ 1~,'n~'"`A.. '-•^"T'+IrT'C:. c' ~ a.• ,_ a a.' ~ 1", 1 r ,.. 1 \ .a / ~ r . P RiC 'v` i c :: . i. , _ e'vitw S 7 /•~t -~.:rZc:l. 12 AU - St•ei.rer - ; 1_rs..^:3 . . 'r. . ; Mti rr, _. /1 ~lt.1's•~~~ ~Iar- . ' ~ R I~ -_~ r.i i'v '' r= i t:7 t :v'... a ii 1 F-. f::.jr r'I rl ,3 e.3 t il a'S i v i ali C Y ti ir i'v C r SW, ; L i;.. . TI - C._riFt: •jS u;.d 1: _ri effects Of yzl:ic vu:.tatar42 ST - TG':kE•ZB,'SS,'S 43•?. .. _ SL rn/ '_ 9 TrS 12. t 4`a7+ r'A_9 -/ wr. n.
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t T' e a t L+1 e ii t 7 ._ nd 3) t r i C •.Ji i f f C rC ii sea i n adver a e be ha'r 1 or a i L ii a i/ gea r a i- 3rtC•.~~i a~ , J ff _"`r f'O • _`1C11+ 4: ..•JL.' '__•73Li'3 _. V~, 41t / ~ JS:7LiJ»+~ _,j•J S1/~_.L 'iJ•Jt~ . - -4 1) ^'r ttJrS1~~ ~~1 . a'J •= /~\.:: bZ: hG V S i.! r G 1 n+{ C• ! 1 j es assoL i G t C' +.j w1 t/ 1 r/7 row1 1 r 1ey `iialamlJCR ari•.~J i=iieAii-ra':.1rle9 2) a cG?1i=ariairic of the a•.ivarse tt=ha'vi3i,.:l • E='ffecta asa::l+=aotCd .:1 t•i MAv treat°i2iit oTi•J3 tficsi ot.'.=urT2C'ig dtJTii/o t'-2ot•C....hi: wl+ `.i ~ • iJti i 'ei' 1i ii_ a -.liJ~J J3.Ti,•t tr'Sc'~ .L - ~.re•a`.ii:•it.~i 1a~Y_••J V i~ . -..~- -c~ri ~ i~1a~ ui/tZ+JC'r 0: L-tr3ptvPhar)a J2::tr'e~7i: il'2toiilfie9 arid lithium curbQr/atc3 3) Wa`-lavioY'i:i.i ic'ffecta of MriC inhibitors in ani(iials which mow have rr lcVaril:a tiJ thi'1i behavorial tv.tlcity in ii4lF.ai4sY and 4) .:•ll:'chetal:"3l effects of MAO in animals and mari which R•a'; have relevance to their boiiavlOrcl '2ffrr.ct5. S 5 al =c r ti1 i{t'C7i_i oti t that ti Z t+{draiJal of iit"1V 1nhZ /+S tor t retatme/{t m0y C lsV 1!a.: as:.iJCiated :+ith :•eiiaviCro: c/,c'•rizes. 140 r'eferencea. 10/7/23 ..2;'.,1C TAI1977'-19140 The veritr'criedIai h3plJthalaCi)Ic syrf"iir GTiei sotiets9 afi+.Ji a cepifai:.= • hc: h5'r.:Jt•i4esis. F'owle5r Terry L. Departmerit of F'sycholoas, Yale tlriversitvr New Hcverii CT C5520 F'sycholclical Review °4(1):89-125t 1977. . Larinuales. . nslish A critical review of the literature on the veritrGr,iedial :1.iMH) ayn«rcmr siJggests several ProbleRt3 with the available e.:p.ianatiCll::.. Zi') ?artiCi.llar% e::rlarlatlorts of firiickiriess ai"td h':.i-err=ha3ia fail to oCC:ou:":'!: for essertial metabOliC changes arcd GGes2tS• that occur ovCr w`cCn f_:,::•::+ intake is i=Ciiitr ::rlled. Aiter riatlvelvi hyF'otheses that offer an acCCUrit G'E' essential r•et•abelic ci•anges arl=, ohesity are unable to e;:r-la;ii f?ri:.•=kir,,. .. _. satlsfactorily. .`'-cmc"• mecharilSH+ that directly cCui=les sensors events U! metabolic resporises Ss Grpareritly responsible for elements of the s':.;ri dr oaie. L-:osed cri the review9 a hypothesis that can account for the firiickir,e:::.=. Wperr'-':1a:32a7 and ::,beslt`_.' seen in the VMH s:'3ri•.";,rome is f:;,rRtUlata&. T~n.s hypothesis suggests that VMH lesions Produce their majcr offacts on feedin:: behavior by d1 reCtl'3 he2ghteriin3 the Piiasic aUtorcoRiic and en•.J.QC'r :n~ responses trllSere•.~~ by orcr-har5,-ifeal contact with food stimuli -- a.:hi:: CeiriialSc refle)(2s of dlgestlori. This PropGaai cc•ii a•i:.cD4lrit for flrilck:.ric=.... e.cplair: the Parado;:es associated with the operant behavior of the lesic.i;: a ariirialr arid elucidate the reasons food restricted VMH animals still fattt:r;. e:, As a wcrkir•is` hypothesisy it is rarsimortioi35, esr:'i rir_allj testable, anj B consistent with Ph'ja:clOgiCal observations on the VMH s3!'idrc i•e. 25.' 00 references. (Author abstract) 10/7/24 0261163 TAI1977-22418 The influence of r-sychoactive drisms ori brain self-stimulation in rats: r'evie::. Wauc<uier, A. De:=ar'tme it Cf Phc:rmaCaleo`d7 .ra'is5en PharB,aCe4StiCay rtie5earch LabCr=tC r.•.t.. B-234v t F:eer,a, Pcllian• lri: kauouier% A. y Brain-stimulation r2ward F'11::•lis^in,• 1975. 6:'2'P. ..-. 124-170; . Lariguase=•: Erisl i :i New "cr k, ':crth-' ;oliu„_• In a Paper Prt-•=ented at the First Iritrriiat217nal Conference on :-r'. ct1R:i~..~a+~,i"~ii •`e ~.'ar~ ~99.~°J) research on i ~i + ~.~~.~i_ i~i~ ~ ~li,ld -ii~= - ..~ ~.'ar~~9 i :, •e2r~~6% •2 ~ ~Si.:Gi% ' ~° c' Psvchoactlve dr't.;m=. Cn intracranial self-stimulation !ICBS) in rats revlewedf iiiclUdi.+g tiie effect:5 of i..NS atlmi.Jlaiit::ai• ciOl:.r•crnics .; ai'itSci{oliiieil.c=•i iiaiiuLi('icgeiis9 aiitiC'cTi'v'i.ilsaritz: minor trariou:lizE'T. n'c3r cGtlc aiialleslcsY aritldef=reaaaritsi h'j: notlcs ai;•.'~~ a.=dat.vesi n: rleiJrOieF'tiCs. Tht'' d= ta iiidiCate that: 1) F's':iChCo`ctivF° vrugs inter fere ..i Q~ !f` r'J +{-iri7.~~i-''-iL ccticri or 'a'v^'~ISvry functions o~i~:~: ~cr i=r i ~:.J~~i :•__ •~^,_c. ~:~• ~ v ~•r ~T•~tor ui~:.J~~i:•_ ~• ~ .. effects throu5oi acticri ori the reir}fcrcirig r-rcrpss) ^: t•he effects J= :ic.;':t gerierall'1 differ fro„ those o'f other fcrR,:a of oF-erarct bei•iavSor'p .•1.1ethui=•Osltivel'= or rieaat2vei, +iiiitl'v'attn'•.'l 3) some effects Cc.3in b+.~e viewad in teT'iii'.. uf'' J F'ua .L I 1.}. er fe. C f( ce l {7• .Z L h FerfOrma ice abiiit.'jr 4) the 7nr-aiii.'•-ierw...• SaSt1s. -_..1 {_. the rr V tv r ci1 trV t Gi id .1. . 00
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ijlv i.k'G'_. _ _ : j~.~J •...zC:d b. a= f - lagi it r rC~~~'C' r{ t L t1:f ns t 1_. C.r t Vf e.e V i{ l:3 wL•- z ?.~i .- ./ 4 .. .. ... 'r:: i rel w 1 t:. N :jccl..itri. Under other .:.irldit.:iaris7 iri:=c+i-s is l..i: -.c` ti i 'e n - -.:. ' d-sis n -F~:.-r2a:C~ - -d fiiv_v.~-i:iti:. 1b t ~ :~c { ~t ~ u i i. Ld -R :' Cs=,.. . e•.a h. .c, : {iiorik2ya .s ri i i a 4h'c-' Puni_ hiZiCi It compl,Jr ierl t 4r f te ie it.=.f i t 1:' i'+? s:_:1:_ d. i c. Ure ]c' { sc:iedUi2 of }i .-OstrC:;n2.ii2rit7 irl.Jectlv.n dos.es uf N (.iV -,.~i..ti mUa/ :''.a) :..a..::1.:..- i' e spi_ rl d1 r i=. ti t.j 1.• r r2v2 r{ t ed? r a t il er t i i a ri Pr o duO e 1 7 N ], r{ .l C:_ F. 1 i_: i._. ..1 6 r._ :. ~~ ...2. ! 1`v 7i-1 /29.: rl~ iiuri a arl ~~L-'/io'J11:~''a i-'/io'J11:~''ai P!]arr.as:oioS'j. PiJiirisP Alari? Plcker 9 i`i:..i,ciieli9 Hali'JorFrisoRs+ Ec:rl :+:tstt'r .. :'ii2:... :c)r. Up K.iiGreia: E%+v C•.~ . l .-~•.J~:.c-. 1983 Fal ~l I tol ~ l Z3./4) 47"-r .9 ,.~..•~~ ~ rrnr-{ { »c~i/_•l~l . C,~ .ecorar ~~~ ~: PYRCAI 0'..3V2" 33 Iol.~rr;o - 1l + H~//IIV•Jli ~ ~••ce,ierit.* ; "~ il0'7 ~ . ~ i 1 ~~~:.-t ~2.• t~~l. I -a.-...-<:~- Y.+^tTG~~i ~ Ti .oc:~r,er:+ , Tsr-e. • . JDLl~iN,.~ .'. .~. 1 ARTICLE) 4`'~ II._ Cw Re'vIL''w'= ti c i:t2ratur2 Jrl t.he be{lav10r al aCtl:.i:is of : ori{i,ributiori'n ±..:i _irider sta'r:dir1g dr'Ua effects in hi.liTia3ris. TFin research ::aos Chaiit2d in 1950 therapy for aci.l«{r=hreril.=s. E'RiFhaslies the .7.easure4Tlerit Of defined ta_ks f 1ri{J ~ ~{ a'ti 1 dua 1 S s. of tr-eatme.Ftr ar;d results are of hFlriari MarG:. .'es2ar cr. involves iablir at.ir'a aril7.als) bUt il(i?.arl e::°r'iairl2d in merital Istlc t2r m:i. Mw..... with introduction of ch1JrprUi'iaziric i Research fAets'io{:.ologj t iat ...._ Wer: a...: aUarttltatl':e C•OhaVior in Or-er'2F loria K.. Ss are ei:posed to raraT:OtY?r'1 (•.~~rum dLsw_' riot are b+?cir".1r1s ,..o. ,_ a2 r V i u1!J t 1 o. i 7 t. . l0_. i'or/rriorr. C'ar aiici dr'u5 effects would be expected in these when be11a'v 1. v r was cor it ro1 1 ed b5 s Zm11 a r e v'eiits rates. e rii= tape ari{:i +Jvse of a dr4Jra' 7 assessrienty the riuriber of times arid tAaSritvir/2d at Ss ISSN: t.J T {J s'a ] r . d •._ _...-. ' ti: -,i_ O . . ~_ . :. the timc hctwerri cdrir;istratio,: adrt+iriistereds rate of absorptiorip etc. >, Previoils or concurrent exposure to another drum are behavioral actions of a dri1g. Tolerarice9 side effects, influence 4ehaviOr. Q 1/ 2 P ref ) 22/7/7 71-16929 Instructiorial control Barorir Alari; Galizioy U U1scsris:rFS :i1:G:oiJkei:: G'`:iy:=hologlcoi Recor d7 00332933 operarit .;ourrial Ar+r/o:JrFce merit: 7107 Larinuale: ENGLISH .:ocuC.erit Tape: JOURNAL 1983 Fal Vol 33:4) 495-520 Reviews ari17 irct2r:-ret= e::F'eri?ierlts and {ii2dIa t:srlal accounts ,,n tzr.,,s of irFteractlF3ris b_ l.._ t. uctiurr? f the behavior. ARTICLE7 which IJ"`..:... •1. 7..:i d1 f I e a i"i ali/ ;:. .: resporidir;g to schedules of reiriforceRier;t. Findin:3s that iristructior,s 2.;or'•. strortg control o•ler operarlt behavaorY even to the e::t+Prit of O'verridi,.._; control ..y the actual schedulef are lriti3rrYr:t2d riC3t a1 a il+:l!'..:ti(:iri _'' reiriforcer{Ferit control of hu;r:ari cehaviory but as iristar,c2s of re.r/forcei-i;..,.. h:. s t o r i e s i i 7 f iue ri 2 1 rl 3 {= ur r e ri t dl scriRiiriat: V'c' 3 tiG1u:1 is behaYiors. The considered arid li"istructi: rc_'fol1JL.Iris to merieralized cogriitl've r-ropoa2d en3erirered vciioerifE'id 1 ri factors in t.;e Ln <r rS •J d C' i riw a t lun 0OD OD C8I!EN: PYRCAI ilEVII Ew lri_;triJctlo:'{S status Of iristrFJct....•'?r.= some .r..lii i J O ri t.. C_ ir,itation noted. A3 of i rist ructiortal between 2 r2sporise an alt2, ..a+..l've .. cortroly a .iew .. classes: rawr or;_..... '•lrlstrUctlOrc i'c:-.'ori':.2 of W. .i, and W. W. Cur.riiri3 (1963)p SCiia dU1E• iaritlrln?r{c12s. Befiav:or a1 arld r2sr''orises evoked by .}.i-i{e a_t'........ outcomes depend oil th.- e::terit to wi.......: f.J110::iriy of ..rf=+...'l.is=•t.ion= Tia::lrr.i.:es sO i i e dui e s. (48 8 r t f,' r'2 1 ri f o r l.' e ui C? r/ t u v a i i a ti? V`F r U CJ n! 1 th. ^.'?/i" /7 « . ~ u % 0- 0'7 5L• •_'• r{ rI o t.{ c r .'.} [. k a t i: i.{ ri t rast :n r i r+f ui t i rr i e s che d 1.{ 1 eri . { r. .,. l1 3. Su. : s BE n A. U i'.•ai I fOrriic:-Bar. Di2fiJ 7 La JG1 &> jF-+u....=l of the ":i"c•r 1{aL•rital Ariai'_i_T=a of Bc4lc"`.is3r9 1983 Mar Voi ?9 ..,... T,'~c- •~= ~.! V 1.J 5 Cw DEE 1 : 1 L_ A Phi U IES:i : V l% t_{ r 1 1 C 1 700f 00225002 1: a a: E Nf?i T:y-•a2 .!r!!!R,>:'.:! AqTTr! cv P_r{iTr1.1
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rei io t.. G r r A h1 i , .ii ai. . i<U i/ i m:i _ F ,__ . t i, ._i l 4 i . ru_~ . . - e c _..=t_.rCa! an~ ' ~ Z.2e• - u '- t ar-rr ed. . ..rrl ai_ .~ ~13'- J-s-d . ~~cri li i iY_ .-." .-. _-t. ti ._ r the de't e. i,}priiCi: t iJ r iv'v 2+ +.t i'L atT.e i-it sV r : L• •: li.. ... . ii:`{ - .,ei i Sv 1 . ... . .= i /liR!1t_i CFFCrT3 I a. '~nrvri:~2 ..2iat1: "'ilirs . ...u T' ••Jst'~.'rr't:.'.i'•y~ •iiJ_. . :.i".i:.u. 1L-.=i:•./riDMiNi~'TG,~-~iTyn~'t 1 .k ~~u^.-Irr.~sJ''nrltrErSr:}^~ ~ Err:~".r..T~'J~'~'..rfryMn''vLv,.,. ... . u ,~ ~• ~~ . .~ . (, i i v . 4 ~. .~•.JJ .. rN1 r/Hvt_i~~.i~~G T I...:r". ; ~~r'ti a Y"1 ir• 1 ri i a v r a y.. i G I r Sci i cd'_• : a . Dr:a .., iIvEra•=4iJ;i 9 ir;1g R2siat3riCe 9 ircC r, i o•-.iCaia rH'•.:To r i'i2C•F`ZaSAiaJti:il`U0 T;1"irir"'•r 'Y rl•2'r,,ew i RC'v..e:,.r ?•utGr...c:.l,. .,.•utlT i Nti4 C R T NT i i':G+` /YESi i'tiv . AU - rui~fto' ji 1 7 • ra~iy:r/: i u /_..G~ i: L1 -' LF c' i= art.3 IT, ; r i t:. de r' : i s: G D i o1 G a i a l Es:. oi.:i P4 iJ l. 1st a d: MC•r i c.. nc i Pc- : iv- ~ f Ems.y. T i ' F 3•'Grrr -O1.. y._~ -~..L•l- ' - -.Oly and . .. •1 .l.'~1l.O.~ ~ !'•rV - i i 1"' i~C L+ler 1L:~..aJ.~i.i iv i 3 ~r.a~ ,1J+. 1~V ~ l !'/5.~ /" 1 i J s Ti~IJi~Ci•VC ..i C' r s V G t I'Ye r ~.f ':, J e ssiri.~ Oe it 1 ~. 1.F/ 1'Y1.~1sv i 1 t 1rzI' L, /t .{'.: ... s Ji ' TL{XBii•i t•C::J.:.v2S7i: . "•,, `-'C1 - :' i "__`/J w•1~-.l s F,~Csi 'IV :'n'r.. :~~7 ;.1"'~:7 ` JY 1907Y r175 510 Cnrr• , °i:.• i ~ .~~~ . J ~ r• LF1 - E'. _. hlB - 1. :eriz=iE•uaenvi :BEi I aP;1Br/y1F-roi-eri2 dar:a'+c.t:.'v'er• i-r:jtl=.=t.i r:-- ._fid ^iiC%c aSo.Iriat ria;;iRic1 eieCtroShG::k a2i: ur ea and iia_ Ltc'~C+tri've irl•G2: i G2:i t of ~ar`via ~. u.. l. 1/ T`.-:= i'i2- - ~'S'iJ .'-U~eiii7r to / 'ia r i=ir~liG.•arvi~. u...~"ci;_ 'r'c3pi:`r LieaCri:•c'a 2::i-ei iTierita Carr:.e•.'~y UUt to .F•Jrti2i Char aC t•er .r.._... tiie Pilarmo.-o.1.Gl:.cai and ti:JxiLCGiGgica: r-r.3fii$ or thia ._GTipi:Jw"..r. `. . L•EY c - t a G 'Cia2 ra:i< •- of f av 111J~`''i n~Jv n. (TI.~., .JJr-.},:? .1e~ • -'r inactive iv/"l e :i r• ~C was iiiol..1.1'v1= e:ir ti?=tCd for ti12 f1i.iJ:r.In3 eff"CCtss aiioigI?i:.aY aa riec•aaiJre•.~y i:y thi:: hGt Piat•e and ai_ctiC al:i d Wr'atiiirrg R.e•_•ilo•.'~y:sY r1CiJ(`GiC=f iC "i ik,.. hi2 fi fc`C~=T, fifc`C~=T ..hcri y.BSte~ J ~ .~'.1'~ the i:atoi2i~aj and i-,_le=cbiul r-tJais: .='o'id.'.tiGil2d a'v'.:iidancG r 2si=i3ri.n2 arid ai-zr:ior riZiiic' :~r~avCc'~::r :,i:•ereGt'_rie'= IT.2tirGdsI and arixlGi'.itit= +efrl?1.tsr /iic'<3aUi-e•."'y l'y tiii: _+-IvC:{."-ei:.=it•2d aggr e_aiVeric'a.n of (Aii=C. Til C.lriti asts tG:?r a:i:=c ; I~ 'i~c ~ c+~r'~ i~' viCGii'v:J {1. 1 = ari 2f1 t -i` r'{CY a3• ~J ~ 'V~ye :irra ''c'~ Gf ~ '.~. _f"~Jn ..rr,. . -±i ~,F2C ~1 ..~ r^.~ ~'~ u,: __ l7raiiyf developed iri :Ti1Ce ari..^td rc:ta .:fter Z.'0 to 40 days S i" coritlriiJed treatTrerit. 3. BEf at dose rarige of 104 800 r13::;:, :Jr'all'aY i=rGi%21.~ to i:•2 remarkabl"-J' safe when Ci-Ir:•riiCal.l.'.v a'•_iR{iitlatered to iabGray..vr'sr' arliriial?. i•i'i1J'al .TJ to V R•i:+iit-i'i 1;1^iifiistr'atiGri of iarge BE dGseS tG rats and RiiCe did r1Ut affE'C{.: bodIr wei'•~~htf b2`iaViora: theaSlJre53 serum and b1GG•."~~ tcsts, CiY t-ier{atOlOS icai Parameters. AriatORiOr=athG1..r231Ca1 eY.i.lTiirla:tiGrls of viscera of BE-treated ariirtials did rrGt r eveal .;1tProtiGri:-• which could 'c•e attributed to drug treatrrlerit. 4. Dzily t•;ei-taferlt {Jp to mGrltiia Cf /^iale rats and ri2Ce 'r:.:ti•i PEi c'st a d:•sc: rana2 :7f 3.''i -i:vC iTi ;r+ka Gr _11y+ did i4Jt affe4_t tr'le rer=ri=idiJcj•i'vCc i:: i a:.:.ty :if ti'i..: <J i r a R i a l .7 . C' i'es1 i a i/ t rr emC y es t r C a te•J wi t// Br U i J r i r Ig • J.! f f er E! r t, f'!_ r a V`J s of sC y t O t i 1.1 ri sa•.I' rG• L' i 1' t 1/ t V 1 Z t te r..• s.4 mf. l. i 1 1, o 1- i 1 V .i C 1J t l.':Jrit r G 1 f ema i t' sI w:hei 7 a•.fiJ 1 t Y D.r".E ar {.d i: Gr tt rG% 1:a t t-i? r' _ pC r f ld imu d ii'i.1Uai iv w21 i in a T a»1 Ve avGi JariCe task. S. Tiia:3ci-Catil t= :•1zi:.. .:l.Jra=' =j orc 41i .r viiV _ e of known 8nti -2pi.laci' t i i dr......• r such 1:_, .'iierlstC•iriY rh21'1Guar..+ital and valr=rGiC aC.i'•_"'Ii and it is . aP_-aEf.'B= - F,.~'i.'}~'fie'' r2a2aI'Cr1-h l o:~ a -i•i:il..-ilu.. ~l -ur- r+.j 1:y•J~.Jt ~'io.F. .L. •C ~. '.•:. 2.ae t/t /e ;• IeG l• meir i of zf1 1 Cr_ w• MH - ii_.Giiivtic Beho':.1Gr i•Di'.UJ EFFECTS Y AriiAiai Y•n.:rly..iC.iravuiaarit°_r . 1r~-C•tG_ i1'C"p3 `~,.~rj'~~!'{'L1L•," Tj~PUrcr' f V ^1JTrr'~>ri3 s J t''v.~, ~•tjJ~"1 .~ '~frr1r.:.j 1 s VL•t• '3 Y L r' •Cpr C• .] ?illi i: .r.•he(iric:3i ? l: Gvc• -r'leai-C•if se rlea a~'i.ZGrialiT pf DTi..im i i rua Taie i'L iicF.: . •T'•4.lectro:viiGCk 7 EuNerlGliJ*ANALuG.:'-' a Di-r\iv1rlTIiwlr..WPilF}r.MACve_OCY., TOXICITY r`ewia.l.e 1 Male 7:'i.ICc2 7 MICeJ in.:•i''e-..'~i S; r airia :-',:,J.ii 'easJrer;e.; t%,•resria.iCy ;Ra; s i Rats, ?rlbred Strairr... Rc`prC•:JvCtiori/DRvi,7 EFFECTS Y f'' ~~y,i .Cw'i2w ~1:: % ''1Cw, T_ '~ rla: . . tereotyped Y%e`avi*. r;'DF:,.lG EFFECTS J.'^3iJi i-l.irtl Wri'U. S. ,Jo.'a. 7 G Q!1
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v tl t ii 2 oC:tiri3 t 1 rl / a =' r it i'.J e i{ or ii• ori C' ti i th .j w i.•.'~~G' r.i rr .j c or a_ t.. ,J . r_ ! ,. ..- _. Cr':.LEE`iJ lii 1973. i t .s fiJi.lrfd 1ii li?t.ir oifj vf thC .:C'eiti i:.fi r i e r ei f 1 C' r v Ju3 s'3 st C' if: j an- D cas i:7 of -.•J} V c~. . F } V/'- IC _ S1J mG t 1L' "v (, O t.L r 1 a r ts as a r/ C• ur f,y t r d rl smj t t C r Y a i 1.J l. 'U A l, .l s_. ..i i.: r i•.";~ a i i l:} r^i or i e. T i i t 1 r f t r 1 ri s1 C T, .= t ab..: a 1 C E f f c C ts A'' 1 ~ _ _ .~f.J 1 r/ 1/ O v C L~•C• 'L••1 f {ve1 1 i r i"v e'~t.~.~5.•tG L V{~.Lri t t1 14 pC•st .}. .) .,r fib:.t3 ti,e r"2:2asc uf G:jtr :31ritcotlifa.: Ccrc tauri= _.. _r e aL' 'sJrr} V: -r 1 C'I . . -1~1J'JC 6r/L = 01/il '+ iV e~~ Ol.1's• r_ JU - .~1Jb` ~ rl 1V~J 1ri 0 t V st 0 ti1 i the effects of the releane of savera.i of the ;,ur,irviic':_ in 4:citc'r-ci2ctrCflat2 h017ic?:•ato•.~1s. it exerts an ..nfl':ci"iar:: guicltiC+ri of several endocrine ari•."~d c.:GCrirlc ftiri.=t1C•ri::.D a fshC•i=k ab=•i=rrber:. iri til2 rii?rV.ji.3a System 'iorfiutv.i.,ct.,..r r2 as furicticris 03 1 :,eurotr•ori5a;ittcr; irttratheCal a:-e=liCryticrf characteristic chOri:;es in the rirstur aberratisr,s. Furt ;err,iarey r'Uterit ai7ci l=e 7i c• .- O 0 Lt_ .1 :> >st E!/. O r i L L• C 1/ S3 vi 1.1 r G:• 1 lt has Cieerl si1Zzested ti"tat lt 7ian M ... ::i.lde-effecta s2eri +Jurlrig arillTial c::r=2r?.iTiF?rits i:i::c iicii'1' . . rior'ktcQ iriC"rea52s in blood AlU2i:i=2f various baif.u'v1Cf u.: c hori_-ies1 r2=,-iratory failureY arid d2ath. Tif.S.a arti.='.,- Cz6r: a;t._ ti i e e f F ect'n arid Poterftlaa slae'effeLts vf a::ififat.:istat,lrf wi'W Partlcular r'EgarC: to tiE reCerit 2bs2rVatlCirf ti"iot thl n suh3toi"if=:= mOn bt a roV C rl l- a r/ a 1gt s1 L • MH - Erf31ish Abstract ; Human ; Review ; F:2view: Tutorial ; Su;iatas:•atirilADVERSE EEFECT51*PHA=:MA;O:.L;CY 1 A, AU - Bioriaf;.i 0 /iD -.Ciel:t:Cir{ Vf ist:.tatl7 Suf2rlur'e d."• Saiiit:,::ii !• , -i/ ay 7 1} 4 Gy~, • TI - M2+..+f1Gd01L+h1-'ai PrCi:al2m3 Zii tire ariai'.a51s Of .~.'•eiio'r'1Jr-a.: tiil.=rnir_i.' in t•ti:.ai V i'..ly• OT - T`3~"L~,~TL!n~}!iJ~~lw~.~'`i ~.~ ~ v ~ f i ~' : J ~.T : .- 30 - Af_df.~r•Cfie~ ~- _v T~•..,,.~:~iC~:~1 ..7 . . • 1 v1f11fr 1 ^ .7u;"r"? ~ y. 1979t ~ nJ i,~9-3;'• tir'.er•-r- : L.~ . ,ti-ic^ . ~ LA - Eri., i1L - The arialy,i: of selected data cri differential he;fav; ort•1 ,e a. ~ c era,ice to +Jr ti>j and other chemicals leads to i; :i.:'ric; 0. tE.eritatlYe fT,=thGdOloS`ical PrGF•OSals 4litif rr7teritlal iriteri?at f::::' the PiJrpQses of tDSilCGl."3gys These data show a wide rarfi2 of different relctlcris cc•etWeerf tolerance induced Ci'_i curftirff.J2d exposure to treatment Per se arid tdl2r aric.;. d222ridcr•t u^rm apcCif:..,_ trt''•at7ierit-behavii7r lrit2ro'ctlOrcSy such as .~"'.•e :a'v1Gr.il ta:tlri5 in the tr eatl:,erit sto'tr and iJrifavVraLZl2 cGryseaUerIC2:" on rBlrifi7r c2mvn,: dE•rislty Os' response CifFsrfgBS induced by treatmerit. CC•rfaetRiJerit•i.''_,. when tJieraric2 +=herfomerfa GCCur r lrig with a r'artlciJlar tjr-c' W treatmerit deserve an in-depth analvsisY a E'>eiiUeritlal str'ati'c0:: ' , sr ioiJ1 ,d assess K) CTitiCal fcC ~tC/rs in s1l ~~ r} ~. - f•2 riT1 C1.)~iir er isa t iC~f i '{ ~~.. r.?E'Yic:L..lar =i deficits ?aC'JtC b2fla'v:.israilSi i.um6ierit•ad tV:eraricc.., .:.1 . relations between 32risl tl:at:.i7rf and tti:.rr aril_.? = crfCAi'c ,r .i c;i't1CiJlc•rl'd irt tifc Case Of ag1~_..y...ri.~ ~ ur i•~ _:ii 1'rits w1,,;- i . ?'~r,_rt .. < 4. oi (=f.J1i.iJir. tl','e r=iiys1v1C•v1Ca1-blUCiledrl.:al 2ff2C±' ). 41:h ti1 axci=::.._ :. i c)`•~`r.rd to tolerance d'r_''veZQr''T.2rit in t+12 ab-2riC2 of Rfe: a.ii.lr2i iC: :.;F3r:c•3:s in the lower t:Qs.•~5c r'ar,ge"a7 and .... .i. i fa.=ti:r3 r 21p;n=..a... l... F`tr .7eila'v aOr ali_ vuamCrit2d ti.iZer arIC2 in e.i2•.~~Iuni'ar,d P_'::i=er,.i;;Cnts. The iatt2r arlai'.d:r:s R•r_in r2i.t••llr:^ tiic IriVcst:.lot..•.Jn G', different r2lat..O'ra between time of tri'atmi?rit• a,', : t 1•. ~. c• of 1,estiii:iY arid diff2r2iit tr c•atl+i2ift"-:.ri:uC2d Chcorlgs s in rc•lrif i'r"CCr-'i_mi, i72rt'31ty. SpeC:.flc arid rrilri-'3-221f1C transfer of C.:1r-:arfs r esi-:r i=:_:.: t: . ' _Li_/ i= _ must _} also L L •C . - -U1/ ~s1iJ ~{CrC•iJ J! Gs MC1 t ~.a C•.] L ` Lr ~.~~J.~} _: ~.j V~Jt?} 41O 1 r.j 1.,' .v .L r r Pesr-'O^isc• tv-"i1sr6: hics? ..ntc;''ir+dl'vldual differences in rate ::ir ~ ;.•Vierai'ri=c de've.vp°.2'•)t as a filrlctlUri Gf size and d."• f CCa•..aa:f of :...,:. _ r.:glria.i ti-cotiTicr{t ciioriae5l aifd .aiC'vCral cth2r CWS w,yilCrf i_oi1 .raCllitat2 the urir2r=tiSndlria of the Gheri0{T.2rio TRV>.It`~,r.TE:~ /. I"1T .~~CC re^F.T~.J~i f l I'1 / L ~ V ~.' I1J C H - r'~riiCiol l 9 i~eiia'~:'iG~'7 Hiilr,iai:!~{i~i~~. •Jiai:!~{i~i~~.• J{i~i~~.• Jrr'f'r`..,riT.r 1CoT•r=or'atl'v2 L V u•J '... Pi o: ,.-~iCi c2iiiic=. i Br ut io:2roifCC ! Eif•vSrvr•Rri=iltai r'aiiutaiii;=„ nX TC T T Y 2 ?.1mr-c C _.=i » /4TiGllf' groC'r^Tf` .
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r'iic'rmacolol'_ and r-harR:ai=:7therai-eut1Cs. PItfa.l.ls of the ric•.31ec+ Lte r eoC/leiMSstr'::9 _ uc/i .vs geiierat:.ori of airiseIeas Phar 7i.aCw..lri21i,S•= &5taI tt`iit`i,ii'l•'.fie•.Ji cirlfi tiTiPi/c:=SZt••.i. (2Ci F'.efS.) i` . % i %1 O5437558 38082558 Behavioral arlt i=syciioi iiysii72ulSLai mar ker .o of dSs.1r"-..iar Cr:.i tittarlt.eo". Mi rsl:': hr Labor'atl7ry uf P5'aciio.l:ogy and PayCi'ii=:l=atiivZi:i.;`.3Y Nmti:ino! !Aat:a tate :r' f/'c' 1 1 V a I 1-f sC• I t( i P C• C t i t t.' `= fJ C) 9 ! i D 203924 Environ Heait i Fer'si=ei t(UNZTED ST ATvS: IIct 1°3i Y ?'': p1^'-?, T[•,.-. C,.P1S ~ ~~ 1-L•L.~L.. ~ i^..•~•rria., l Je! r.. .., . ~'c•:~e . . EIO • ? Larigi~a•ges. E;'iGL-~c-{ • ~.eil . , , /= , ~•aYlC+ral ari+.7 5 :c~iv/=il»SJ.ioSSCal aaaaya fJro'vS•''.~e the Z.C=1 sCn=..t.,..,.. :Lrtf•jica+•lf=n of whether a i re s{JTied rie{Jri7t:.r:(iri has adei'c•terloi.{s effect on tk._ rie rwous _y=terr. The ef fects of lead Cirl .e t`~ r, ' ricr'v'O'•.JS sS~ste7r are =t"~' ~r_. .... S'JmestSve tiic t this s_J2rit .:ail r-roduCe dSSturb3rii=2s Sri attcntioiii AiC1r23'vzr' there are clinical rePortS of such effe°::t:a. The art:.or1 of lead is cl':` EiiortSfest in behaviors described as ":Ijrreract:.Vey' or reflectirc5 'Bi:.riiG.o:. GraSrl Cama=:'c'. ' T.le cCr e sy(:ii=tvi,r in biJtii di3orCJer s ls Pr.iba/=•iy Smi aIrme:it ...;, O t t e r I t j 1 ri . T i i e i'eCeri t DS agi( Lf st S V a r i`J .J .F, a t S:? t A L ai Ma rl ua.1 . If ,`.i / 1- i.T. i) of lr i... "~..``ri.o+ .- 1 - •c~a tS'uri i~S~'s + 1.r-. /e • t+"~•i i+ a,S •Cri a. n •EfSC.St Ili- i~e:ierSCo~ f F'or ^7.L: 1-S ~ L~,Io + .erRl F`iu x• Ci r w t: T .-l:f replaLk= ni.JCn +i,ermS as ii'dperactl'v'Stj ailf.i iL3.riSma 1 broir: ranralc. ?T.ii:. : tudS=a of tTe bei-.a'v Sora.li t:i::lc=Sty of lead i7.an h~ J ~ u'v'c'-' ~~s~ •- ~• iii3•Je.<i.1utC' r . .. ..nct7r^,rrrlete aSac'•y_ of atteritSClriP this could 7r1 :'art account for '~:i-.... `v'arSabSii:r`_ lri outt=o^,ea. Recent research ori attaritSoii :3•Ji..iesta that it ..._ ._ cl')TiF'iE':x behavior ._or11.1tSri.a of a ri{Jricfer of e:eS.eiita or i=v7iF•OriC?r/tay each .:1' ZM 'fferer i~i S C'i 1 (i.c:'n ::•+~ ' ' i r r i' '• i~ t +.~~'r~'i {v-•'i'it ~.~i'' V ri a ~iS rt riCtS Ur{ of the C'arrt ;...; .. nervous acnter:. Behavillrai assa» should e'.•:aTiirfe th(". C'o7.='.'7namt=• ::;' attentive DEKa'.'iVr Wiin.a tests which are nerfaStit - -r 'v e V trilC f.y1•ff'C'r..k.. eZe1T.erit=. i+•. is reCiii/.Rierided that +YsychC'r'rhy5ioiol3.i_o1 aSsays c:7 or i i+r i V e c• V e i i t- re i a t?• i PLi t e ri t S a 1 a) 9 a 1 ti-i o i.J Ah (fi i.i re J.'t f f I cui t a r I•.'~~ a:.i a+i. ib .. i.. imi'iemer/t/ be used as weii. These aasayS was FroVldte a&ore dvriixl.SC .._." s~' altered iriforz{ation Processirig in the brain arid help to localize L;-i::: charact•erize the hehaviora: irirairmerit. .50 8efs. ) 91?/13 06395558 88041558 The radial arri r„aze as a tool in behavioral eharaiacolons. 02 tor; I,S Departm2rit of F'svcnolofsr Johns Hopk•iris Ltriiversitvr Ba:timorei MD 2121`. I'hysiol Behav (UNITED STATES) 1987Y 10 (6) P793-?, IS3N 0031-9351 .J t++.3 r r/ G a V.J f1 c• P72 Coritr=ct%'i rant No. : ?4H24Z13 i_.arc gua_c= : ENCL. SI; 7S1Sa i-a'r'c•r- will r e'v..ew C+r i2fz: t(le i:se Gf +i.he raJS,ai arm lii.i:_a on a to-. to e~';a7..irie the ri"c'ui'ai »>teins tiiat are Srl'voiVaf."•d in 1"({e/7/Cir yi uA: l,ir..: irif 1uei1c e of =iia r i+:aL :J.l.'L:gI C a? clJiS.r-iitJrld:7 Gr ( /i7c'/if'V` rS. Vf i-ar t.'acni:• r 3 i1t 3 es: ,. _ the '.UeatltJr{ of task vai:.d2f..a/ which is anL.: a:e•.. ~w reference to °o". diffe. S -1 J r C/ 1L i~r 1 tC r s O: 4~i~ei'O t i r~riO1Y r~33C•i1V j VAj 1~.3.~Y C t/~ V 1 V:. • L:=l Y J-'J r 1 r1 C iJ 1,_ ... ?see "~ Zsf.i Mr _ i=il 7 •..i { 1= .. =sue9 C451 aJJ 1 1^ Y 7a.I.J ). Va•L 1-1 of t' iC 3C t 3r _: ,.. .al:•J~it= ~ :. • :_ rc..e::cd be.. ,ow. C79 F:er s.. i ~ :lrI / r 1 `I 06390105 880351W FJ.:.L d-'di f-.e z._..iLf.l i 1at itJ/i ilre•.i 1cat S iJrks f IJ r the t r eatiireilt >_ F r iy^ C r j.C ns.L vr. v C . St.aca: .'e'r'it:r.•. n-t rY - ~•~ %~r _ rr =tC iii M VI . zi:'i'hr_+iG='s ScCt:•Gri? Vri Med.:cal Centeri M:aRiiY FL 3v12Z. ._ ` l..n H_ •i'Cr _a . v / i• ., r / t_ I~i1iT`*t r`T4riTCJ) S~~i 1907Y T - r` -Cr r v . .. . . ,_ 7v ' ' ._ . G1 48- ;,;CX .:L,ivr'r,v:. Cvdt • J„L Lor1Suc;ae?: ENC`.Ta:3H, As..e de f r olir t^i e r•G• l.r r il spe ct.1 'Y e .7 r 1 O j'.-i' sa 3 V f CL v r ir. G r/ e T 1zoI' 11.1 '~ l 1 C+ i~ j i:: -1 L Li 1 C -ot i 4rzi a C f..) stuJy i 3 7 i.• C iC 1 1 dCsig1/ C•..i spo` 1 f 1 1,. J a J.]] to :3 :7 s._ - 1 v''JvG'n.OxL's -.ed .....aadrarrtalas V'IC firaerJ-'.JVaC arltjtf.3Y'eri'..'rl::}: vC LV11/..•1tIG iV'r.._e v __ A __ F L . ~ + l - 4 - l _ - A f - 1 yGif.~_C_1 ..tr,.. - l
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~ ~ r _.r1iJ, 2i A ; • ._: ir Jri ..` AU ,., 7 K1 C 2 r. iic on L i'F , r_ rn , ., ~.:Grie'.- a.• P:o6:man - 'C•si~~'='i.~C'r~~'='i.~C'rLC'r L•i~ r~• ? Mt:j3i'C'Is L i Les:.urii..J iGrIC- T• WJ. i• , ir1 t - ,.,c~iiGe i TiiC roi=b E`r a i1.1u tiGii ~'T Ooi oiu Y i~ta+•i oii.•1 .•~'ii•rfC C i- .: i. ;t i i,.o,. c. . Btti-iesdaF MD. TI - MerCiarGri?: cn t aiititu{;,Vr aac'rft erit:•r irfi Cllril.:ul t: ioiL. ~ ~oC%nnt;~^~-. SI - i T~r2.~. .F:IF:,~•~~, .,.,~ ~ `r.: t,~, a• rr ~ ~'i~,'-~.'~ ::) Q - I{-c ve s+ ,. ?c•«t .~ r,• ~- U 3~ni wOr~. ,.i i I:`' .. 27 la::~'Y lR:. LA ~ - Ci isr : MerCiG r1JnC I n VC• ter NY.1 i11 rig aS- _ite ti....!.cI t_ t and Li"G lau.:.z„ii.» s;ii.a t' r2C1iri2Coi tor::CQ1Gg'3 studies Gi ci '.3 i• e a =- 1gf'i i f:. C a e'1 t f a: t G r to c i iriical t rial stat•'s vn +,.hc basi =• ~.-~,., ag,~irlst ~,.•o ,.i ~ ).S i.~cvs^.' v ~i rt.~ ..i tacir15+ ,. .L r~ • a,~ i L u:2~. 1ar iCiRia oii•. ~ ~ sorC- n1=• .i. .,- .:3i_ t1'v'i t'7 ai-rcc7 r, to bt"' f lu'vGi'.a i.a a i Vi'... a. :.ilJrotil".•i .".•i. Of aj i ..11ri1stC'ut:avn. Thc iTiaCrianislil i•f oCti+=n ,:.f T.c'.:ozo.i... .i s i 1 iJ t 3 e t est a i.i i.i si-i c•.J} bt.j t i4t dCI es i r idi r cC sI r! gi C st r a i{d C+ 1' ea i:. _ .. .. DNA ,• oi=pti"entl_ wI tilGUt bliid:aiig to DNA. The r'-ilar if.a.:Gi.Sn•=t:.i d._;...• :iin the dG=: .aiid.1,=c.ite that cZearai:Ce r.e'Cliar/:.sT.s Ria':i .:~•e sr.+tura.:iW. ~. ./G/b~ ~ Ji~V1 iC is { f':~•~(`(Ji':a..Ot"i.i O~t the "~" '1, i`GsitS.Jri in l . ~t.~ -•1 „ ~ ~~c r<t ~_i:: u'if.J C.iiigY aiid siuCvr oiiZ•.~~OtC''fJ in tffC dJg• F'Or erft di 1.ji iiri•.J~ th,1 hur]ra.._ mt-~'ta.:o.:.tC are e'.:creted in the 11rSiie. If sat:..lrai :c . also ~. +5.i.....il~ L 1 LGC /~ C i/ L~C' /. C• 1~ 1 1 O i I j"J/1/ 7 O.~~V f~ C r t O a r% t G iSi O/ i Y t/ f1 s W a 1.l Itil O r/ 1./ ~~ .:iifuSiJii 'ate :s3'i7 thCrefore steaU, stote CoriCeiiti at:.:ii._ r.?a._hr:..: ifo[Jerater' ?„=t1'v:.t:d :+.=s devc.:v=e J .:ts 'curative' activity J i C MH 2! r^ J AD rSs:nS iuril: a 5-doy CoiltlrluGiJs i:ii7 t'ie r= reC 1 1 r I i l: a 1 •.jata. The .•ii2?c vritis W:11 Lr crucial in the 1 yiT.i' iiisl •J re'v'ieal2d that ma..jur tara,=t ti:=•UL:_ V rgUris77 tGlie ii'•ti'rGw t r:i.7trnlrit2:'"•tlriol tr:.:a, u n•J iL 1 U rI •C y. C Gme i C ii a'v i i.i r a 2 slgr is ::J r _ iSteiTi tG::1City ::er E observed. Phase the cCCiT= 1UridY .. nc111d1 rim ~ • • !5-Gst' 1 T T J/ 1TT 1I L~''. OaIJG++,.j Vii • rcZ',iers:iiiC l.i•r1tri l iiCr .,.."... .Ta t r.ails 4i S" ,_ ~ ... _ .. _ .. 6Vlc •ul2rli., irltra':eriGiJa 1 nfu3iGn 5:'he•..ulc C:...._ _: Fharcr.aco'r•.ir,eti.c iriFor,:stiuri f, c... FJrfur thEr clinical "•_~'ic'v e1Gpm=;.;: ... , sele,=t:.o^I of the C'J; t.iR.ui SLha•.J~ulc(=) -poi' - Ariima1 : r'irl+' irieorlastic A.Seratsi'F'HAF:ttACC`:I4.-.TICS.'T,^v~TY.' ~~.TurRH~ ~ a.• •i -`~.~r+JTI,.: `' r; ~.•=C. ~ ? • rrl.in ~ cl .a.•~ i, f ~. a+ ~.IGr1 i u;~ii~ti i ~tii i Flt~'v "•4S"T•-',; 'icW t r.,.:iv:.. "' iTC!)!IrTT•.~i TrstC rial y Thi,.itfarbituratesi:.,~i~. i a 'i ~'-Ir'~ft^M"rSr,..'^4•I~~~T"v..'~ v~ i~ •F THE R r F• EUT IC U•:> L - Reiter L:: ' NetJrotG:::.cC:1Gss lE1':151i:rriY United Statea Frib'lroriT.ier,tai Pr.;itt=•t_tiui, fiimericyY F:e,Er_rch Triar,3;e Part.r N.C. TI -Neuroto.:icolo5s; in r2gulatiori arid riskk a»essrier+',:. SI - TC'•XEIE:iCSIQG?9b1 . ,.~ i• cC1 - n2'v F'i~.. ior,~irCJ' .a TilerY v rrOL f.~~Y a "::1:, ,~"' `i 19.,~: ~i i r'z,,~`~,,, .• . i. 4-6" ~~~~'rr. 17) LA - ErlL AB - It is well recognized that a wide variety of cilemical5 2::E r'1;. toxic effects on the structure and function of the riar'.;.:u:, s'»tei7i. ':esui=tGr_ ci2riCies7 C.iormav ::.:ti-i ti"i.= r'=ri+tcctLoif of hu~o;i hc`:o:th fr3Jm ti:;"i.=orlt E::i-JsurL-~.SY sioUl J til,.e iafGre C.::nsiG:'1. G'v V i•J G t I V ri 7 .a / I t`I C r J:7 k ,:.-• -a:] :7 !,. ,: 1 1 t . r,J cG.:. 1. o':e/ the 1 ~ _ _ cst •:~c'1=o~J2 Y .~c'v'2 r o i c f~-e i t ° a. i cl_ _ ~ 1a. •v.. te3 t i nj 3 L / 1 C me1 f..r r C V(? 1 V C t i r/ g r/ G•J r l.i b/C ./av i\..I I tl 1 l. L• i. A L 1 ty. i i 1 jei'iCic;Y i',llc__ i-:=i'i'-_-'is have re•_LrT.Ri2ridCJ behavioral Zi.?.pjiJTct.:; I' E r£,_f r 1.•CV j i. t<Ji idC iir ,tii,Fii 1 rieu1 1J.~'•' Ct11G a VA.\ L J 1 e'v a1 SJq ti!Ji. •. i i. i;8i:"rlni with `i.,`i i,t iB=C' t'ci: o?iiTi2n~.j,atlOr/sr the Cn'v:.rGriTis_nt: 1. r'. GtcCt:.L.. iilei1i:Y iia; dc•'v'K'vrCrJ je'vrCrf iiei.Jrato:i:.s_its test laidY:ls r11.s f..r w._L iri e'v o iua t inn r i 2%.: an•.'~d c4i s t ing c h c' ,u i C a is. r:. { r the r r 2 r l r l zmc i 1 t c_;'.t2ila:on ,Jf these tc ;t 31.11d21ir{es will flow fi:cTi a bi:ti.•z'ig un'•_JSe r:: tarid.. ri_=i :Jf the ._ c.a.1ui a r/ci[:11eC Ui a i' 2V2i7t3 Whi:=h .ii• dc r.~a ... :ieisrc+C::iLar,t- i.i•.~,i1cc^J f:.;riCtiCir:c,i o? t'r•-tL•7ris. r}~~~..r~, i~i'tTLi~~.~`~ Ti'i'n,rt..,...;', t`iH - A:.ama.a y i'IiJmcn %Nc'r :GU= S3ste{:. .T.'.a:ie.aa.= .sip• .~ .~. .~~ _ _.. rl.l t-fCii v ,~ Ti '~•1~~nr'•f frS''c'~..a ~+Gi..,ii . i'.' .'.isn. . '. r--:,--.t. f k ~~' ~T it'i ' Y ~'ti ? ' r~C~11ewY . _.„ .. ~~ : _. i.liaTT{,~IIa..t.' ~.F.T><.a/TTr!^^ /Yr~'.`/x/f1`. 1 ~ ~ i tL . ~... it~•. WE.r[`:
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of f{J+•.,'.r .._ L/ci la . a..7 ra i tJ;;i CGl/.igy r2 si: a rC` ori r C;C'(rY7.Z11: ri•:.i2i': a tcr/+la r•.J.o! i::,t.: nEui o+i.i=,.it_-o_;e;._f . = i utilize Cer talri S±.rateg.ies: (a) Focus Grn est:iSl.._,,__-,uii::tur'es in i i2 c..:•:i:'Jrili.erit. of lr:ter'esit or sele.=:'t e;.r-os+Jres of ,'-'oi tic.... ... Ci3eiiical cla:_es7 cor1s.d2ririg r'=G=iliatlorl size and 52•ver..ty of effc:=ti ,r. t1 .•/~2 3+ Vv , . .d•J "'~ G1'' .~/C• t r --4..1C• • ~•~ 4I i~C f'•.~f~trti~••.+ 4C•JJ rlJ'. - .t` Ensure iV, 1C~1.~ a ±: iC ~C~IJJv_ of ^• rC.~.OC !. + •V ~1 vC _ U.:i-OSurC in trr'- _ cri':'irJr!mC/-~t t f 1ii -L2T'r'St! s - •ri•~ -t t-. ,t r•C1 12s_v .. -+ +-d ~j i~ ~:~+ ~.:~ %i1+ u,~- . _Lj volldita for r:or7-ps`dChL7i.:rgIStsY uair1g reference Sub:tari.:cs. i..nall`= 7 ,..r_. rlei_irotJ::lc:ol>-!si=v is urge•.'~ to consider effeCts related to su°r•t.3 .3s weil c._. health in vfclvEl.:1i'irit his/her rt=earCltl. O !7/ti 1 04605775 8214277S • iilcurGb2rea'riilrol ef fd =ts of tGll.lerie. . a rC'w'iE`wa Beriizrius Vr, • u_rG',~JrC•L•s_.c-.!rFa'v 1 -.:;.:~i_ia.a ~ Tc2.r'oS • l:1~.:n+ ,.ar 19f+~.. i>< ~ ~ I4: p-~,;. ~P-r-1ic UY i•~~.~ ..,..,. ~.. r.+„ ..,n.-~e--.i-;.`-.,".. ". T•J~L .J.i Jo'J1riG I L`dC: i ; t k• h , t- Gr{3uOgG sf Eit l." Li..~'F,-1 TC•luerie ar-peor"_ to 'rr"t.duce reversible effect5 11r-vr1 li'ver, remsl i'1er'v'Gl.is sy=temS. it1 usual route of intake is 'vla Te3i-1 r at2i=+r/ • The i'cervai_.... - _~ar'-B3r_t +/s_. 12 Rrt~n~, i~ t+- eE E /r ± •Vt1•Jr t2im vr= r '- B 3r_t - to - C~~C , ~+ sensitive 'v2 t oo2~:v ~+ v~ of .Cri2• i~ii ~~i_.~ _„ri~~i_. ~_„r- .~_„r there are few studies of tc::lIJer.e's r{e1JT'nt::r:;lcit•y: coR•C- tenuous r'esults ,.,_ i.~e cited. Hll"i level tol{Jerle e.:i-o5{Jres e=rGdiJ.=c''d ir11=J::,r'dIria:'.lor{i al-a:::i..... 1-if:cor/=cauu5rle=_ and ev'eritl_3allwi death. Lower 1i:'v'?I acute e.:Fo_ur'cs in .r.._.r F•r'odllce d1z..irie"os7 exhilaration and confusion. Ai=t:avitEi );''vel i-ia= bc_._:i4 jria•J'L'1'Z71J6tel'> >V{ldjed• Sl_ ie•Jule cVritrollC•J be/-ia'viors Ilo'v(o bceri rE='i!i"tCJ ..a.. F°ror+lCe lri'v'c r ter U-s;taped s=or{ceritratiori-effect curves ori res:-onSc' r..z t._ SiieasiJres+ F-1lteratiGrl'1 at le'v'els as low as 150 T'r=m iia'v'e iaecn rc•i-Gr ted :.h_..i aF'='etlti:e co:^.tirl:cricieS are used. E.lert few stud1e.3 of the nervous SO=.,s_n, have beeri P8"fi:,r^,ed at ie'v'els below 1000 i=rm arid Fio3t of the reSult:r .._,,. 2rFCGriClu11'vC-' •-'• Te`. /2 ~ .~/i T°Ls ;+siesilCillJ J z i1di1+ ., t.'u.. •.:e:i,•.:e: of •ti"c~ri2 !"/c•S u '-t_-er: set r tGi,. ,.... ;.~`i'.i ="r=i{I for a hrs. No E;;='GSure5 on Poaaible gr".713i-3 at s: i:Cial r?.^_::.> such 6... r'cr.ircatali aged or „mi=cl r ed s1.1L''IJe.=tS have been made. Few sj•i.di:: s t.. , r eVer'sib:.lit'3 of LOfectir in the r{er vol..ia syst:: iT. t"ia'v'P Llperi ri?i'ur'+,.cd. M'..._rr more workk is needed before strong coriclusior,s can be drawn. (60 Refs. ) 9/.~ /22 , , 04515695 82058695 Behavior ar{a25sis arid e.:perirt+ental Pharmacology. Todorov JC Neurosci Biobenav Rev Fall 1981, 5.(3) r-30?-14. t;'8N 01 ^9-; .v 1 Jourrial Code: CA? Lar,luaaes: ENGLISH This i=aFer r=rG'vides an i'/trG"•.'.IJctiorl to ~./`It~ field ~f '. , -_' l. of ~ ' ~Ci-ia.`:.iii.. PharRiaColGg':. Fi brief desLr IF'tlori of tilo C.airi ciara+=tar.2 t:Cs of bei/av1.ui onaly`':lc is fi.lllvw2d by a review of the cJrltrlbu+i.:Gf{3 of 2:.perii7.e:•/L._,. FilaT'iFc:CGIGg: to 1=1ehc:viGT' arial=sis ar{d vice ver sa• Firlaily, asri :.:.ur'i on iiC'.i•- F rocedurrCs in beila'. .Clr"al A'ilarmaColGS°d :i:itl:.rtes e:ir'erl•i:erltal si tJat1Gn= r, ,,.d•J J ~ ~.~.~_!2. ;-.~•i + w~i1C~i Gl:ie i2;: i.irl•~1 Gf .Le iaviGr Cai{ + ~..a n+u1BU• T e/eSe ir1i=1 .•J. .•c1.=z. .:...~ IJlsC'r..iiiirlG•tZiL•ri? .b. Preference to bC free ari•.~, irifurz.eJY (c) 1_Vr,,,,iteicr.... L" { 1 o i L' ^C' O rl d se l f -4 or/ t ri.! 1 1 G r/ SJ \ SJ % i 1 1.7h-1J rdC• r 1.t lJ r i{- c r {+ {of' H/ O t 1 V ri • C63 C. Cf... 9//~/'~T I • r.._ 0435135/ 81179357 MG s_r''f 1 L 1 1; v 1eC IJ f cGw1 1 1 t 1 v C• a rl J { url ct A 1J r{ O 1 L' C 1 i G V i V i• a~/ a? 1ys.:] :] : 1d a. ,/ r@siJltirk3 ti'7er ap2utlc lriter veritiori5 in a T.eri{i.al3y /=+i,a: dc•d r='ii'07,ariii;>c I MoS1lCiil.elteri kC1=,n..t1'ver %.lrid Fi3r:KtlGnalrr /vr•r2'laltc'ri5arial'»c l1nd :...~: dara1J5 c•biCi terrder Thcr or=icari"aav:.t' fur Z2ist:.z i•?illri ier"ter; BraridstiftL 1'- ~ ~<[" i= L ! Cc~iE'Pr ~.• Z Kiilr r`saCriC•l C'syi:i-iot::cr :9vtii 23 (Tr ~ i~22v~"-42.r i =.! N 03's 0- u .i 9r{ .:otirrFal Code : `.::1,' • E~'/rt~.T{"I.i i_ariS`uc•-'ABS. ~11 ~ V ^i~'t~~i~•r5? L. ~•u°riiary ~. 1ariguageS. ENGLISH Ar•'or.t F"vr„ Scnci ai 2"•_'~i1.1Ca:.:.iJilai arl•J t•ri:'2tii/erlt. Pr<:::=vit=,cs tKei-n ,. Fr act2i:zllS no the 7,C-'ei+i.•ally L 1.l ~ I l.Z li 1 V.~. - r• C~ 1! O. . Zttar„r- t r-e (iG r'•.~JCd in r=r o'v'id1r/a Spi_x.IfiL r2ilati11+..a+i.lvil r=ri=•:.~r ari,? f:.. J ,•.J! /~ _ :7•.J 1 t fi r esC U t~" • /•'1f V e 1s L:'.1G•f 1' C'. i C.•r l: : P'j . r I.i.!~~J1 cO~1V r/ 2+..i:L]d WS':1 rh Ol' r r'lJ!3ti 1C 5 :n il 5 e l f- Cv i•:. r G i t. r i•ir i i ii 3 i _ r, , , 3-.o 2 .° O
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4Li 'V«C I 1 ~t•1 1 • 1/ ke drj Ii O suaa2st that fire settiria b`..: t.rfy S•i-tS+cn,. CurrnOt 1:1 1_ c'J rst C 1l pre7J i 1« 1i C J ,? 1,•J d2st\ uctIVE t iat Flr2`s.9tt2i i 31i7s'J:Dr ma'.i be oo ci:oTrs.= L1 ` L~L r C~.f O r' 1 ei`iGv1 V/! ! % 7: 1 iJ 05445091 35062091 1-` e e i avi or.,7 l t L7 ni S- 1 ty Vf L rj a.. 1••. a1 ai. a r i 1.. V iir r U•J i 1•J 3• O r 2 v 1 C` 'V.7 r Re:. t 2 r' L:+r S ROPPtrt PH i /'Y eIJ i" i7 to:: 1coi os'.: ,C., i: i i ri i 2r 1984Y 5 (2) 2 i7?' v\7 ) 1t.i Si\i v.ii L! \.~i 13X j- _ • G~~rrioy r L•u~~e~ ~•i-ir LO i isuG_'e G• s• L. NGL• :._l H Ti'ii.. ~ t~ial ~,i\~ , ~. 'Cr~1 ,: «ii•:} • ti'i„i2trlaltlri ,T _ .J= 7 i'~T: ,~r'+e iici~I`vtic r.~:7^ ,- .. ~• „ .~ \!- :O{:irourids which rrGJtr't:c2 different Patt2rrrs of tvi:li:.:;..y in adw+'t a:rlr„s'..... E.:i=usiJriC to TET rrod:.it:2s behavioral tu:;icit3 (1Jtcr"'!f1sed R•\ il -~v..1•, . ._. . ~ j sl-ir •~,. . . gr'1p atrer•Igt,iY vi=era'it respGrtSe rate aii•.'', startle r23pGnS.- asr,=lltud-c) wh.,.,., reflects icraired ncUro6;otlar f;liicti0ii. These 7..ic'fic.:..s are consistent wi,..i the i'epOrt2d rr•_:El:.r, •vacUCiatlaii arid cerebral 2u:71a i'ri_Jt.:1=ed b`_. TET! wit i its dir',:ct CfF2Ct1 iJri FcusCl'c. ":i-(33ur2 to TMT r T•aduc•=s .".•: i.;'r iit,'per3C:•1'vit's ai{,'~J lar'=a:.r2d l2arr,:{"1g ari4 i-erfardlairCC• Ti1C:i2 lTri-ai:nf2nts ,.. consistent with repar:cd ric't.1i'O:ioi cell dcath .:'a,JUceJ bs TMTJ :=ar tll:.i_Il"c, 1. 1 i l 2mbi c :y_• t C' m :J t ruL t tJ r C 7. Yr 1'-{ 1 1 e t 1-/ 2 V e1 S'V 1Ci CS 1 J\. f.1 l• i ts i r U•J •J cC' 1 r epeatEG ti;'rGstJr t to T.r..T are r EVErs::2 e when vC5$.r1= is t@ r l'riilat!'vY L E/ 1 a'V a J r a 1 am/' :J .l r//• CC 1 7 ts r I' 4} \J uccd Ly O n1 i 1a.i 2 C i. paS ui' 2 t V TMT ,7 I- r C O r3 t o .ir re'r'@.'=iblt• .3Q Refs• 1 9/7f i 9 05439751 85055751 Behavior arid nUtrltlc:rri: a 3ciri2 r2'v'it:'W• Rapoport JL; h;rt.;esi M,.'• i'iSBC .. I'ent Child Nov'-Dec 1984Y 51 !5J r-4°1 4Y 133N 0C23-0u13 Journal Cod;:: HXZ LariAvexes: ENGLISH The fiii7.}i^I;: that tMere is an effect ue=ori iii2..>i3reRi2ntS relevant to =•t_h•_.•;.,;. i••'--'rrvi'ma^.:Cy dC'rc`'if7Jii3 oii whether Ur not tri.e child 11i• J tri akfcst :•r,... .. • , iivriiirtsY iio_ =c-~',;i ti'1'rloa oriv like LURiISion sense to oiiy i-ar2n+i, who Kan r,,. ... to rec:irid their child not to leave for school without br2s+kfa! t. \re1,.7 it ... ~ an 2::a7,r 12 of a iiyi=u tii+Cal s f Irial i, b2:.rf! test:?+'S. C.: ff c:.n2 .n n ciRl l•:. r en c.m_r a Li JJ l+i. s t c i•i \. : t. 'L 1 i I i r 2 asC^' V• 1g1 l a i i C e • Dr f fere r i ct' s .n r i caff2:a i i c' Cfr C c+,.. s2eri amG;•i g v2ffr:•r2iij„ i=2r'si}ifaZlt= tapCS aii~.J: aRlCic..ra thnse who >clr'-sc.'.ct=} O r low a,i! G t.1 ii ts •J f t i-ie s t lm:1 l ant 1 ii t ii 2.i r v.1 2 t 5. r ri 2 r c 1 s Pl •_ -.. ,._. . i-i c ii a'v .2 O r- a: t:i :1 icI Vy f:' \a ii L affc.l r{ c' in i1 C7 r Rr a l [= f"l : ldr - - e;~. T`,~~~2 sel2Ct2ng f12^-.i1 caffeine diets g2rierali, do ri0t Bra7i to gc:• ricnat3.':ti. . s i..rr~ii `7r~.'c~+--cr T,G_~ -1 other C• •2312fs o~i ~:~~1t ~• ..+t~tlu`ii:~ia~ eff2:1..a.i. effects of foods ...r~_~ (iutri2nts =rc facts or m'3tifS still needs to b2 detcr7iiiri2•.J~. Until cdca:Jc:-K.. '.nC1en:•1f:c 2'...•..2r:c2 is +=01i2ct2dY Indi'v1 dual bi: i:.:.rs a: ;U: h':?2r c:Ctl'vIt'd =1c•:} i=rl7re ',uSt reT.alr, only L2l.:ICfsY i"7?.aai'dlc» of K_.- 5trOrlgl- ,-uL•llc Pol li_y Gia•r or ma:n riOt endorse thCTi. n± t:i] s tiiGci t:c'r.= ,... ~ f~iC3 r'r'D'r~.e ccu1s.. ^c'ioi'.ionSil1F. i'iare att.1d?ic5 wltfl o+."~ic7wct= dCS:.fii -ctcil.., i=r 2 ik+C2 d2d to a5 scss behavioral tO::.Ziit`.3 as tie.i l an the b?if2fit/r::srvk r,_ ....,.. of ariy 1':et8r s rirc•riii-ulc•t•IGii. 9i` • /2.1 05371542 84295842 NrUrobehs, ior•al ';,astl:ia ;rigE. r 7.:;', Qf Ch2rrcical3: NrG't-ir0b?F1a'V T•.} N.. c_ i TC-' r ata1 V 27v~-1i '•JL•~ ~V ' Vt''1~•"• J1^ IC1 • J -7 ~ U~U-t' • I t X). 3 ~.t '_(4r iitJ «: Gs'L~~3 LN:14 i.-..' 1r 0..:i=t'1r.1='0l Z _+? ±t._i nR,2rl~ • _u_ ~~ i-~ii LL '_) lier F i -+,+ c . i^I C,•; i i l r 46s .? "c' r'v G•~Ji ~ N m OD OD w w %0 L" I f• ' O c}le ori r 2 L tJ /11m'C' 1 1'.~Je•..i st 3 t/ r.} •3 '•..) ir *'ia r'-i9+= r .i.934 Y '~J Q) r'fA/~.-cJ~ - 1 7 _ - .. ~ ~. ~ i.iJi 1f t-` r~Ci ici: u~ tJ~:'~~ 2 i i i\• /a ~i{i.o~ 1i r dv c i. i.r- a.. a:a a TiajGr •soUr\=r of 1nr::ri.i,3tlori ,.., . rE'cO,:;i.ic'i~= ;c•;iic'i~=;c •;c• s.vrc2 \.:-:i-O=•Ur2 ZimIt'=• t Thrr se-iU l J CilCm.lcal= «•'=:1t f''E'aUeiitla eiit=otJrit2r$d t'v';;ii0iC3:c = 1o(i2 r.Ii=aiiL.'2. A revl2'.•.' af ~ d2•T,•~a:la ~+ e ,`•c:vi= Qr their Ciie :1i.:3.25 ro; iii.=r, t`t2y S_ i i i u + Li7iit Values li i• TLw7 '_ . f.., ~ _ J. .ir,it.~s v, ~~.a oir.~ i=•r 1=.:•iL..•.;. the 'Y•,iCCTH at.t,icu;,\2rrtatic:n .•uGk, \,rh...._,. J:3dg2jfi72iit' Y has indicated thot :.Lt-r th,= _ ...., . cssianzd rcCOm?•BndCd 't$iidard5 ira':^ci rus Q',c a`z; c°°2: t- In -LdeT to iroc re-ai-se the ir:,F u\_':
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. ='F~';' or ~~`;r °"a.~cJ ~ r. .r,,.t„a '.~d S"I= 30393, + ff ° e V uf i V ~J•. 1\ + Vi 12 C l, t+ i+ :~ V w,. •.-- - +. r ._ .- a V s.. .. a ~, a • ~ ... r 1 . . . •- .. by Vf ~ie L•t a, it}'iV1 11 sV v.-i 1 23390 bV t 1 eot by r iO+.Jf L r 1•..iV 1• r 1!..~tsy, 10p.,a.- r. ~ _ G r ._~ 1, e i G•JlriJr2;=:ei-+i,Gre sliJ:•i1St5 EoFVi,ivrFiiiil2r .-) ,1 PC'r'IY as wcll 03 duroT::ilci =.i... 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A i•_: t a v r i flor1:{ o}i. 3 uSefu1 1 i i f. i 1 ,1 iui ut.'i i:o av 1'? +.. 1 oi i S a i,d d2:i a; r r. n...; #'l1ti b rc rE= -t'arCii - . 1 T _J:A .'d•J4:On8ii'_ 3eiiT:i:l r''S`3CCio^h.::51c5 has f:.i=U":S.?d Gir ta_...... ;=ri.:i?StAcri= of uculty and SLi1-Ativli.'S :threShC+iii. r:i=!iiJrid the.a r obvious .c, ...... in the Sti.1dy of cu/i.Fai'oti'v'C Sc'ri'oGry fiSiictiur{ and eL'{7i1.1ti.:i1or`.d d1:'i•C"ivr mcn... _ _ ~ L• V4_ 1 e S i: 'C r. r C2 r 1 l. iC( ets r ra. C !~ r,J t~' 1•J e•J r O-' r t 1 c iJ j O i' .~ '~ 1 Il r i 1.! r}Vant r1 eLi I i 1s1ge 1 t_ A. rf. ... tiie iJ"i~1=i';.,.~:idi~'i= of erai=^erai .a~?riSo'ld t' rciTio•_i~'~.+i-, and J PrCi::C'S1..ii5 ~' ~:~' ', ... ~.., ~ ti e i i' i2 i,3 t1 v T-1 to i- c,'" C e= t 1 Q ii . Our Ie :; r e r .. 7t e ii t 5 f, rS vi? G i' er l car r i. :: d out ..,. ~ r c3i'iiTTiaiS whose hearing has beei'i iAipaired t`'.•w drugs and crSOle:SiGr-i5Y oTr•-' relations have been Sou3ht between the Suu52Cti1eClt hec,ring 1::.-•s an•'.-~i hilc h15tDF'atht7lO'3' ICol. cila.'iSteS oCciJrring in the a%_T•.'~~itOrj recei-tDr cells of a;.h.: lnrier ear. But thre5`iOZd SeriSif.iVlt'.3 25 only one of tTiuriS Percr'rtuz; CIQieTi51o1"i5 and tells us iiOtil2T•fSt of the dl!"crifi3riati.oi"i5 that are 1^,+ade c.,at,.- St1RtUil which are Ciearly above mlrilHlUAi detectable IeV2l:n. ror e.:aRcFic.: CfiScr lriir3atlLlii= occur alCiig StlmUliJ:a dimensions such as 41a'JeZeiigth of 3.IShtf sound i-r255uref acoustic freti=Jeric'.j, and so on. 3eCiSOrS S`..:Stc17iS alLr.. Per,^1:it the accurate location of the sourcc of StiiUi.li.:.t;On at adiStaC+C.-Cr the SelectlOn of certain freoUeiiC'Ie5 Or rv:vVeieriotil5 and the rC.iection or o~•1~• •-. ..L-Vi-V'~ .s.-- ~'' ti 1t'r:~.1 C~ i3J f i i 1 f3 A 1'~ V, 1e 1.%1:7L r 1~~ 1'iO VLVI 1 O 1r V~ ig 'V'L71:~ ltITI/"l-C~'i. 4. y.,• V+ V 1,.• ~^1.. ... useful SiSrfc:i5 such as .5-cc'Ch• ProtOt':ii1c3.L e::i'er'1T.ent5 are •=iC...cribi•d9 :..r... i i2 3 it i Fi. 5 l ua.: c c 4 = Igil ifl cc ii t a ri d u r•.-', 2 r i•j r 2:. a t i D iF .' 41 Itii rE'+ r 1. i= i, c2 ' o i sc i, _• ,:. T. ~ . . Fi'C=cc:7=.=1ng mecicfli2m_. ii1= i-C1`•12r of vi'rrarit C+Chov1Gr to C:::aiu:ane rarCcnti...;, f r1JITi a `'r O rA tty of rC ^LY l4C a A v v. _ is +.il sL.u37C J. (18 FiCf s. , 9/7/4 . 06618214 nVnn .ll~.-• a...~r`l V ~ ~` - •2~'c+a - ~..r aa crsc_i,'S of iilltom2r12 on•.~~ its oii+i,t3l:,rilntSi a r:vl'c'r.s whi t e >.1 I}~`1 5 Rai11 L• u 1 v OR D2pa i'til+_ ii t _ f P>>ti li'1]ii_ S'_ P Moifa.Sh tr'r-il'v i= rS•1 tyY Ciantv 1r 7 V1't_-+_r ~... . V ; . huv V. G a A C• . r' -_ - -. 1- 1 ~ ~ ~~ f v F r,•_ 1 r,. __ v A;_ _r 1 (i• ''2ra1i i) L. 1 . VCC1\?rt~.i~•1a1 tlYY w_. i erSf) 1988Y 95 (.M.) r-.~ y i iI. _ 1. ~`.`IIS ' f1V 1`V 1^T C'.•~+..•• -'-:.156 V• V ~ .rI. _G~A r».V'J_t' l\A i -. _• { 1_.J^t1uO'3C~1 C}1rL.1JH - t7._i_i.r _ iC - F_ ._ __..r~_C _.r . A C' ev -. P i - 00 t. i a- IL.• \:, t 4 6''. a V iJ t O i ef f le C t S of i 1 i:+i. <U m1 i e o i r d ~ i ._ .... _. 2 -r e I.
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i1+. I•2c+,:imca Clt'ar th•3t the iAo•.~airic3tions `• F 1_Jedil•J'_ _j yh= CJ:.i _ jOjilC`.J l''3 1Cs1.J1tj/l> to _ _ OL'3 _V1 -~, ~•t•! .• `~c.•_ . _L _ • a~ r i t. i V •s_ .~ r v cJ ..l r, _!.. , _ ~.. ;L . ..'.Ji.,r11. .V.3.al.t? C_ !.j1Vi "... . P/ A L_ _V 4 +JJ _v.._!.,_ _ t i C.._ -V ~ /, r'• -1..,. ._ - - a= oii;~;iC1 ~'di a=,gr~cs62VEri2a>> oct:'v'lt'~r ~ .~t ..... • 'L'' i{if`I/asZ zC 1 the di ffC ren1r1 aJ Cf f ect= of S•i r iJg7 l„1/ i v8 r j•,Jus L l.iia'v i rJ !s, w• 1 i cr/ ... F' r2 4^J r 1 L O t C` foiii. C• V i l.• !/ u fJ i_l l•J t C 1 f J 1a tJ 1_ V 1 Is.. dL r a.., Ca'J 1 v O 1 a/ r V• O/ 1•../ •J .J C G~ ... J ail°ir=Ze iri+.~e:x of aoe;iE' 2 Qi;aelj d/cfir.ed i-iiar.Tracululi.:al i'rar crt:2:i. iaha::iL; fJ•rfde r" t•ii2 coirt• rvl uf =vera1 •v'e at iu.:.il 1 r r!y w' idca an 2;•uTr: Z c wL I.:ii :aliustrc..._ _. the neie_sity to relate +.AriJ3 effcata to 2:.i-eriT.2rital3:o d:'firi,?d •vs'aa:,t-_r ra.ther t;iari to ir+validat•ed CGr,st•ruc:t5 rC..1.3t:t.?d by /=ra3cr/t day -ci,_^t. P.,.... f'aycifOla'gy• Tiic variabillt'j of dr'i.;g 2ff2.=t3 o.=avrd•.r/s tii thc ki.l& ..., ."•i:i1a'vior b2ing cC:•+r:sid2rCdi ir{teractiCl:•i• .'~c'!"Sa.ior •a`ioul•.'~i not U111 3 as O dCr C•1/'J2• it v a r i C. L• j c' • T r a di t i t.• ri a l `' e/ 1 O'v 1 V rG'6 l c11 O 1 C• Cs as 1iCIC•iier:iicc:i ciian=.cs. in V L+se r'r ei.! G t L• C' i i O V' 1 ti rO l h0s l Cr'J to S/he ;_ar.1..+Cr-{ 1Jf be tr eat2d in • 'r O r i stle! L• `-j t r C Y C r i t uO L j'V / a 6 r. ir idLr pC i r J E., t. 3prrQac2s to ~,~ cir rr S Eti •J C'_• r i.. E o Soiire zas25Y i 2'v el5 a r e to :i-eciflcail`:, bc•ha•. ioral `r'ariabiesf rE l a t L 1 J 1 1-'r bC' t w C C r i t/1 C l.m rga r i 1 s1// 1? / 1•.. ) ra1 sed L+'1 O bChO'V' i IJ rCl O{ICGj y7i sY t ; V•ci7o'v.oT'al '.ics.... LJ 1 .:r.V1 1 _ f +J• .•J Jl'~r1 °~ !/ {> s.~{-~jVo1 cO 1 61, :t t• '.a IC c' :L a t ri a t r= c.i r+i. of t ii e c• r f c i_ !. ... 4r..' 'C'::r-a ~ -v':+iilL•.. tL-ld ' :._tC_ii` L•J d:'3 1411 CZ i Eii[ C •.. , Jr Y irf other 4i?r/asi D~ tii.' 'rt_!_iJl.i ... , its Eri'v'ZrlriiTlc-°r{t• goZ.ic' ty=iccii i=ro:+i,..n._ ari tiiC f iC• l'•~, vf tal.7 r urlcC •J'Ji',- ~• exrer1 '/iierl1 VG1 t T1v' 1 'rl: •L-~C'U C• •~ '. l• ~ . ~'J+J1:-1'1or 1f O1e ,-t LJ-i :,-l.~.is3e'J ~• . /'~ ~y•L!•11 ne1 ~ _ r r •J i ~ ~'/ .!I!1% 06499535 38144535 Recent studies in the behavioral t0>aicOlo3y of ELF electric arc+. fields. Lcvely RH NeUrOSciericc5 ;3rGuF-t I'iattelle;, Pacific Northwest Lai70re>t.]r ie5, Ri:=:i?.a WA 99352. I F•rot Cliri Biol Res (UNITED STATES) .9C8r 257 P32?'-4?, ICSN 0361-7i 32 .;aurrial Code: F'Z5 Lariluales: ENGLISH Beiicvit7ral r c'ar'=CrriS2= to ELF electric and TragiietiC ficld:s ar 2 T=r~C1 •'r_ _. .:.i,•vr'tlri_, with the =.'imile sCr1sUI"s awareness or detection by arn a:aii.ai ...~r.' rlliJ V 1 rlg or} thrLIugh /!ror'F' -L Ll/ilpl I c8 tC•+J L+Cha !•I1 or'a l r C'.7r Vr 1se:} s•JL i/ ..~ 1 \•'C3h=v1._ ,that• averts 2i.PG1C;r_. The Z.tcratfJrE Selectcd in th: : r2.'i2w i_ ta....=., 'i=i' -- - ./7ior'111 fr=+l~i the area of behavioral to::Iav'iv.~~.'iv.~~. ~. is -f.fchY it . ~'ic: ~• .r_' .. re'vie6: work Gri :oi c+_iallzed respOri52 SySte'IS to FLi' f.I=IG':a. Ti'ie i.rat nztai:•D:. of these _m;tt2d $i-ecialized r2aaGr/$2 S'.dater•fs are El.?._trGr:?CEi-ti. r.i ;_._,.. :\alCli..lri 7 t i.ia v i:riu.i1c, Y which occurs ..ri o :iuilf''L~2 r of f isif ai-c.=i%csr ~... _. hOrilrls/iio...gatllln _•id t_Vmr•:f1r41catlari Of the location of food tiiut 0.;::urs .<.,. s@ -.l.~ ~~!- - l-':.r+.~ J_r• ar{:J J ir i 1 1-. 1!•J1 i -•-e'~L+f-Cesi. i -i2t:t.:''vh1 a:3 • • 1 ~ - „ iL--v~il-- '' =r-•_ ^•LiG~_ ~~'F L: t':, T/1_ + V•1,. . :: .. ... CCie:itati.=•ii i:,f 'io?t r csCariii2= that 2'v'aluut2 tihc: cffect5 ur° e;;r=v3i.r=' t11 r...,....- 2let=tr'ic ar:•_i magnetic fields has .:+2ei{ iiiflu::rit_Cd r riSicrils ..o l"... r *(ifi55iOri_ ' C~ F ~ F s',~Oi.E and the r-C,rwer iii•~iJStr''~ i=r%~„"'ryr: 1ra to dctCr.ririr t~iie iice-ri-..rr effects r;f PV::er freaf.;~iitis ..r•iv- arid v0'Hzi +2ilatrlc .:ri•'-. T.agiietic f:el_,_.- L'tLOi Jse i Jf tI 1'C= -e lCr rO-..c fi i•aa Vj -:. _ eff4r' 'V: Ja V of s~-L .~~• %-rl. J,..~ a~I i l/r a VI/ r C l- 'C' r t t • a:7 eC• ;•. r/ h as .: rl f a L' t bCerl •:{ Qmt a t 50 I,! r V li i-I :, • in t hi: cU ri t e:: t of t il e a.. .. .,.• 3liititotluri=Y r2mar'kabiy few robust behavioral effects have bi=Er: r:_ =or tv _r. ThC:SL' t/ cat i ia'v C [•eci i r tr v rt•c d a r C?'L"S•y: l_i rclatC to an c•r/i'/a l'= FE r::. EF t•i oi i i_ F. the =l2ct•r.c fi2l+.Y sltifacJgh there ar 2 :i?lir? 3::cl?r'tiGriS ts=• lc'r42rali:-:.F.l~iri• The or=i=orcrit Ia=!•. 2,1.2terI.,iJ`.i "'ffi:ct' in .ar i:~'.al_ , lack i7/ '~ •.~ ~ 1 ' .. ._ CC)risaSterit with r 2ce:it studS21 on ' /~"7tJTla.is tL /ot have bt'+c':'1 conducted ,aii :.h:.. ta I I4:'• _ .~.. 1.~1 •. f~J •! 1 ~t is teiief-t1 •//g to _t e+.ro:3•Jrl: to +3r~. _ -. r.~1t._ e t~ii= conclude tl{., (U .~ ~-_• ; i e l d .1'_ a , ati ic r .s ni Ivci1,Ju= E'vl.~t rft ari•-'Ji Y oti/e r ti iar{ r'os; Z L• l c• mi r11 -sr laaka? ... ... without i iaza r•.~ • i'ioti e'v er. r 1 f Lh:s j 1s ti iL t_ astY then wi i.ut "~JL i rsi? a rr' :JC S... Glok2 of r-c=L'rt= of alter e•-J/ ifef.Jr al function (other than i:•.=ha`...ur, . th._.~. result °r:7n, =.:FQ-?urc• to ELF fields (ev!. 7 Sar'r=r2552J T.2iat:rriln a`rd ENM c:ct.'v.ty :cn t.e r'av irieal; efflfs:. Df calc:uiA i:jils frGm brair{ 1::zi tic...... h Z st l.! l lJ u i L a l l_ i I a i inC i r! t hC ce r'C•' bC l •,i fd 1jf a r4 •.J. h i!' ) oi_ a mpfJ 'D f iJ j l v w j i 1g P t? ra ri at,.i. E`;:P! :4Jrc! ctc.). rirC th2.'--rt 'i+?:1ra.l efF•?Lts ris {T.t:Jrie ti•c,il 'rio.i52' t,: ...,... b'c:ia'v'in=: or'wani=m? Poasibl2 reaatJrt3 form tfia +'{..sr'-'arltV GCt..:22ri co~l.r. biOlD:dy7 m_uroc/r_;ii3tr_r a,id '.``..eilavior- ha'vc .:•2ert Pr:?serit2d in ti')i.3 .:.h•5; t__• . c;il:. ' , ~:a_c•~ _~i 1I,c - ~1•c,-~•Vhesizcd reasi:iiin f..:i the C';.:.st:.r13 d1spar'..ty7 :3 ',U;;..._., vf c::Pt r.. rr"c'n:•_ ..c i c- =Jz•rastt'd. (13 r'Ef6. )
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