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Joint Meeting of the Ilsi & Ilsi-Nf Board of Members.

Date: 20 Jan 1990
Length: 155 pages
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Developing Nutrition Education Communications Programs with Emphasis on Vitamin A, by Intl Vitamin A Consultative Group, 900000. Guidelines for the Development of A Simplified Dietary Assessment to Identify Groups at Risk for Inadequate Intake of Vitamin
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15 Jun 1999
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Comm, O.F. European Communities
Rutgers Univ
List, O.F. Anticipated Attendence
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Intl Life Sciences Institute
Malaspina, A.
Lowe, B.
Fondu, M.
Best Comm
Elton, G.
Kroes, R.
Eec
Sugita, Y.H.
Filer, L.J.
Food Nutrition & Safety Comm
Olson, R.
Usda
Morck, T.
Agency For Intl Development
White, J.
Dutton, R.J.
Hopper, P.
Henry, C.
Natl Institute For Environmental, H.E.
Epa
Mohr, U.
Duncan, C.
Coleman, S.
Withers, W.W.
Purvis, G.
Horton, E.
Weaver, A.V.
Fulgoni, V.L.
Kellogg
Middlekauff, R.D.
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Cummin, A.
Bretsch, G.
Natl Center For Toxicological Resea
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Brookings Institution
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Anderson, M.
Franz, T.
Randerath, K.
Barrett, C.
Natl Toxicology Program
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Lefkowith, J.
Boekelheide, K.
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Springer Verlag
Jones, T.C.
New England Regional Primate Resear
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Hunt, R.D.
Capen, C.C.
Oh, S.T. Univ
Dungworth, D.L.
Univ, O.F. Ca
Grice, H.C.
Cantox
Us Natl Institute, O.F. Allergy & Infe
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Andres, R.
Macdonald, I.
Harris, S.S.
Univ, O.F. Al
Vanderbilt Univ
Leaf, A.
Human Nutrition Institute
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Farmakalidis, E.
Mcpherson, M.
Australian Soft Drink Assn
Christian, J.
Intl Comm, O.N. Microbiological Specif
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Univ, O.F. New South Wales
Dwyer, T.
Univ, O.F. Tasmania
List, O.F. Novel Food Comm Members
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Vergallen, H.
Houghton, H.
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Jardine, N.
Obara, T.
Malaspina
Konishi, Y.
Nara Medical Univ
Zurcher, C.
Imber, M.J.
Harvard Medical Univ
Hurt, H.D.
Quaker Oats
Japan Ministry, O.F. Health & Welfare
Aibara, K.
Intl Life Sciences Institute Japan
Greenwood, C.E.
Univ, O.F. Toronto
Baly, D.L.
Klein, S.
Univ, O.F. Tx
German, J.B.
Johnson, M.A.
Univ, O.F. Ga
Song, W.O.
Mi, S.T. Univ
Hoffer, L.J.
Mcgill Univ
Levin, S.
Wa Univ School, O.F. Medicine
Mason, J.B.
Cousins, R.J.
Univ, O.F. Fl
American Institute, O.F. Nutrition
Marth, E.H.
Univ, O.F. Wi
Goldstein, J.
Boston Univ
Rosenberg, I.H.
American Dietetic Assn
Gordon, D.
Univ, O.F. Mo Columbia
Fda
Forbes, A.
American Heart
Harper, A.
Castelli, W.
Mattson, F.
Fitzgerald, G.
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Grice, H.
Taylor, K.
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Page, J.
Kaufman, S.
Natl Institute, O.F. Mental Health
Leviton, A.
Childrens Hospital Boston
Eastman
Hercules
Higley, N.
Schweppes, C.
Chappel, C.I.
Senzik, S.
List, O.F. Caffeine Comm Members
Barone, J.J.
Neims, A.
Merritt, L.C.
Univ, O.F. Ma
Skrypec, D.
Bruns, P.
List, O.F. Color Comm Members
List, O.F. Diet & Behavior Comm Member
Miller, G.
Anderson, G.H.
Nnoka, C.
List, O.F. Food Microbiology Comm Memb
Henning, D.
Johnson, D.A.
Featherstone Jdb
Eastman Dental Center
List, O.F. Oral Health Comm Members
Greenberg, M.J.
List, O.F. Proposition, 6.5. Comm Members
List, O.F. Residue Comm Members
Trautman, T.
Emerson, J.L.
Coca Cola
Cumberland Packing
Pepsico
Royal Crown Cola
Schoenig, G.
Intl Food Biotechnology Council
Hall, R.
Smith, R.
Arnall, P.
Kraus, K.
Rogers, S.
Kirschman, J.
Fordham, J.
Glass, D.
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Intl Nutritional Anemia Consultativ
Us Agency For Intl Development
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Morck, T.A.
Lindsay, L.
Gerber Products
Pradilla, A.
Intl Vitamin, A. Consultative Group
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Middlekauff, R.
Bloch, K.E.
Bolis Cgl
Univ, O.F. Milan
Cummin, A.S.
Dews, P.B.
Duncan, C.L.
Edwards, R.A.
Ernster, L.
Feldberg, C.
Fulgoni, V.
Guardia, E.J.
Hayashi, Y.
Horisberger, M.
Hornig, D.
Lasagna, L.C.
Leighton, C.C.
Mendez, E.
Mossel Daa
Ohlson, R.J.
Plummer, D.M.
Sampson, H.A.
Stanley, J.W.
Sundwall, A.
Wishart, A.W. Jr
Wogan, G.N.
Mckinney, L.C.
Robert Wood Johnson Medical School
Moore, J.L.
Mead Johnson Worldwide Nutritional
Univ, O.F. Mexico
Borzelleca, J.F.
Clydesdale, F.M.
Fulgoni, V. III
Goldblith, S.A.
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HUMAN NUTRITION INSTITUTE ANNUAL REPORT BACKGROUND The Human Nutrition Institute (HNI) was established in January of 1989 as a component of the ILSI-Research Foundation. The initial focus of the program of the HNI is nutrition and aging. Although the elderly segment of the U.S. population is increasing at a faster rate than any other segment of our population, scientific understanding of the nutritional needs of older people is incomplete. Only recently have we had access to large enough groups of healthy elderly individuals to make detailed nutritional studies possible. The mission of the HNI is to support research on the role of nutrition in the aging process and other nutrition issues of emerging public concern. The HNI is using its unique resources to complement federal and other research programs in nutrition and aging. Such collaboration is fostered by the affiliations of various members of the HNI Board of Scientific Advisors. The U.S. Department of Agriculture's Human Nutrition Research Center on Aging at Tufts University in Boston is the premier research facility in this area of research. Dr. Irwin Rosenberg is the director of this center and is an active member of the HNI's Board of Scientific Advisors. The National Institutes of Health's National Institute on Aging (NIA) has ongoing intramural and extramural research programs in this area. Dr. Reubin Andres, who heads the Baltimore Longitudinal Study on Aging at the NIA's Gerontology Research Center in Baltimore, is another member of the Board. Under the guidance of its Board of Scientific Advisors, the HNI is developing a program that will complement these federally sponsored programs. The members of the Board were selected for their expertise in the areas of nutrition research and aging research. A list of the members is provided as Attachment I. Because the world's population is also aging, the HNI's program is also addressing issues outside of the U.S. ILSI, with its four international branches, is uniquely positioned to enhance research collaboration around the world in this important field. One member of the Board, Professor Ian Macdonald, brings special expertise in developing international nutrition programs. PERSONNEL The Director of the HNI is Dr. Suzanne S. Harris. In this capacity Dr. Harris manages the daily affairs of HNI's program, including maintaining close contact with the members of the Board and with other organizations involved in nutrition and aging research. Before coming to this position in January, 1989, Dr. Harris had served for nearly four years as the Deputy Assistant Secretary of Agriculture for Food and Consumer Services. In this position Dr. Harris assisted in the development of national nutrition and consumer policies for the U.S. Department of Agriculture. She also oversaw the nutrition related activities of the Food and Nutrition Service, the Human Nutrition Information Service, and the Office of Consumer Advisor. From May of 1985 until her appointment as Deputy Assistant Secretary, -12-
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RESEARCH AWARDS The goal of the Research Awards Program is to encourage young investigators in life sciences to use innovative approaches to expand the scientific database for dealing with nutrition, health and safety problems. Through this program, the ILSI Research Foundation provides research awards of up to $100,000 over a three-year period to promising young scientists at leading research institutions around the world. The purpose of these awards is to support these investigators in applying innovative techniques from rapidly developing sciences (e.g., molecular biology, genetic engineering, immunology and neurobiology) to gain basic knowledge in nutrition and toxicology as well as to encourage career commitments to these areas of research. The priorities currently established by the Board of Scientific Directors for these awards emphasize comparative toxicology and nutritional effects on development. These are described in greater detail below: Comparative Toxicology: Investigations on the basic mechanisms (systemic, cellular and molecular) that explain the variations in toxic responses to specific agents in different animal species. These studies will contribute to increased confidence in applying the results of animal studies to humans. Research on differential toxicological effects is of particular interest. Nutritional Effects: Investigations on mechanisms (systemic, cellular, molecular, immunological and genetic) by which specific diets and dietary components influence growth and development. Examples include, but are not limited to, research related to hypersensitivity, cell signalling and the role of lipids (such as polyunsaturated fatty acids) and calcium. The application deadline for funding to begin in 1990 was September 1, 1989, and 28 applications were received. The preliminary review process has been completed and 10 semi-finalists have been selected. The final selection will be made in early 1990 and two awards will be announced in February 1990. Investigators who have received or are currently receiving support from the ILSI Research Foundation are shown on the following page.
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Patholoav MonograDhs The Monoaraohs on the Pathology of Laboratory Animals are designed to facilitate communication among scientists from academia, industries and governments involved in the safety testing of foods, drugs and chemicals. The complete set will cover all organ systems and is intended for use by pathologists, toxicologists and other concerned with evaluating toxicity and carcinogenicity studies. The objectives of the Monogranhs on Pathology of Laboratory Animals are to improve diagnostic criteria, to develop internationally accepted terminology and to determine the relevance of data derived from animal studies for predicting effects in humans. To achieve these goals, each volume of the set incorporates the following features: * An authoritative, international perspective on the pathology of laboratory animals is provided by the authors and the members of the editorial board. These individuals, who critically evaluate the accuracy of the scientific content of each book, are selected from the leading experts in pathology throughout the world. * A concise, standard format is followed and a uniform nomenclature, which contributes to standardized reporting and evaluation of pathologic data, is presented. * The text reflects current knowledge of the biologic significance of each lesion in different species. • Pathologic features are carefully identified and correlated with biologic and toxicologic data. * Detailed microscopic and ultrastructural descriptions are given for spontaneous and experimentally induced neoplastic and non-neoplastic lesions as well as the histopathologic manifestations of infractions in several species of laboratory animals. Gross and microscopic features and ultrastructure are fully illustrated. * Information is provided on etiology, pathogenesis and incidence in specific strains; on differences influenced by sex and environment; and on the application of pathologic data to the evaluation of toxic effects. * The effects of genetic and environmental background are evaluated whenever possible, and differences between species and strains of laboratory animals are described. * The frequency and significance of specific lesions in various species and strains from different geographic regions and laboratory environments are depicted graphically. The first seven volumes of the set have been published and are available from Springer-Verlag. The last three volumes are in preparation. The titles of the books are as follows: Volume 1 Endocrine System Volume 7 Intertument and Mammary Glands Volume 2 Resoiratorv System Volume 8Hemoooietic System Volume 3 Diaestive System Volume 9 Cardiovascular System and Volume 4 Urinary System Musculoskeletal System Volume 5 Genital System Volume 10 Eve and Ear Volume 6 Nervous System Volumes 8 and 9 are to be published in 1990; Volume 10 is to be published in 1991. Two additional volumes on primates have been approved by the Board of Trustees. r -7-
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ILSI AUSTRALIA ILSI Australia currently has 13 members, down one from last year. At the Annual General Meeting, held on April 16, 1989, Professor Ronald Edwards was reelected president and Mr. Brian Lowe was reelected chairman. New officers elected were Dr. Efi Farmakalidis, Kellogg (Australia) Pty Ltd, as deputy chairman and Ms. Melanie McPherson, Australian Soft Drink Association Ltd, as treasurer. At the conclusion of the meeting, Dr. John Christian, CSIRO Division of Food Processing and Chairman, International Commission on Microbiological Specifications for Foods, gave a presentation on "Current ILSI Research in Microbiology and its Significance to Australian Industry." Plans to follow up the ILSI International Conference on Nutrition and Fitness in Olympia, Greece, with a parallel ILSI Australia event came to fruition in a seminar on Nutrition and Fitness held on April 17, 1989, at Manly, a suburb of Syndey. This seminar attracted an audience of around 100 health professionals and food scientists. Ms. Wendy McCarthy, Chairman of the Management Committee of the Australian National Better Health Program and Deputy Chairman of the Australian Broadcasting Corporation, opened the seminar. Professor Ron Edwards, University of New South Wales, and Professor Terry Dwyer, University of Tasmania, both of whom had attended the 1988 Olympia conference, opened the technical program and they were followed by an impressive panel of speakers. The National Physical Activity Policy drafted at Olympia provided the basis for a vigorous discussion at the conclusion of the seminar. Seven papers presented at the seminar and the discussion will be published in Food Australia 42(1), January 1990. Copies of the proceedings are available from the ILSI Australia office. A recent event in Australia has focused attention on monosodium glutamate (MSG) as a possible cause of adverse reactions. It is particularly appropriate, therefore, to conduct a seminar on this subject area as had already been foreshadowed for 1990. Several companies have expressed interest and an organizing committee has been formed. It is hoped that this may become a joint activity of ILSI Australia and ILSI Japan. Two issues of the ILSI Australia Newsletter were published in 1989; No. 10 in March and No. 11 in September, which included a summary of the Nutrition and Fitness Meeting. A survey during the year of the current mailing list of about 500 indicated an almost universal wish to continue to receive the Newsletter. Brian Lowe Chairman 0509D ui m ~ W m w N J J
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5 TECHNICAL COMMITTEE ON NOVEL FOODS The Novel Foods Committee was founded to prepare a protocol for the toxicological and nutritional evaluation of these products. The committee organized a number of meetings and prepared a document that will be sent to EC and national agencies. A workshop will be held to present and discuss the document. Novel Food Committee Members Chairman: Ms. Prof. M. Hicks Beghin-Say Eridania Group B.S.N. Hoffmann-La Roche Gist-Brocades N.V. Monsanto Nestec Groupe Pernod-Ricard Roquette Freres Sanofi S.A. Sudzucker A.G. R.H.M. Tate & Lyle Tiense Suikerrafinaderij United Biscuits Scientific Advisors N.V. Prof. Dr. J.J. Hermus Prof. Dr. V.S. Feron Prof. Dr. R. Kroes Prof. M. Roberfroid Prof. G. Goma Prof. Ir. P. Dysseler TNO-Civo TNO-Civo RIVM University of Louvain University of Toulouse CERIA (NL) (NL) (NL) (B) (F) (B) ILSI Eurone Staff Prof. M. Fondu
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EDWARD J. MASORO, Ph.D. is chairman of the Department of Physiology at the University of Texas Health Science Center in San Antonio, Texas. He received his Ph.D. in physiology from the University of California. He is the chairman of the National Institute on Aging's Board of Scientific Counselors and an Associate Editor of the Journal of Gerontology. Dr. Masoro is a fellow of the Gerontological Society of America. IRWIN H. ROSENBERG, M.D. is the director of the U.S. Department of Agriculture's Human Nutrition Research Center on Aging at Tufts University. Dr. Rosenberg is also a professor of Nutrition, Physiology, and Medicine at Tufts University. He received his medical degree cum laude from Harvard Medical School. He is currently serving as the editor of ILSI-NF's Nutrition Reviews. 8U71S -2-
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-6- Ms. Coleman also reported on the ILSI survey which was conducted among the members during 1988, pointing out that the results confirmed the importance the members place on ILSI's current activities and their strong affirmation of ILSI's involvement in risk assessment and risk communication activities. X. ElectlQn gf Trustees A. LLH The nominating committee consisting of Mr. Roger Middlekauff, Chairman, Professor Ulrich Mohr and Mr. W. Wayne Withers submitted its report. The following individuals were nominated for 3-year terms to expire in January 1992: Dr. G. Harvey Anderson Dr. Alfred S. Cummin Prof. Ronald A. Edwards Mr. Charles Feldberg Dr. Victor L. Fulgoni III Dr. Enrique J. Guardia Dr. Alexander Leaf Mr. Reginald J. Ohlson Dr. James W. Stanley Dr. Gerald N. Wogan University of Toronto Borden, Inc. University of New South Wales CPC International, Inc. Kellogg Company General Foods USA Harvard Medical School Mars Incorporated PepsiCo, Inc. Massachusetts Institute of Technology Upon motion duly made, seconded, and carried, the above named individuals were elected Trustees of ILSI for a 3-year term and until their successors are elected and qualified. A complete list of Trustees is attached to these minutes. B. ILSI- N The nominating committee consisting of Dr. George Purvis, Chairman, Dr. Edward Horton and Mr. A. Vernon Weaver submitted its report. The following individual was nominated for a 1-year term to expire in January 1990 to fill a vacancy: Tlr Victnr 1. Fulonni TTT Knllnoo [`nrnnanv .-.. . .~.... .... - ».o...~ ~- -----~oo ~,.,...+,»..~ The following individuals were nominated for 3-year terms to expire in January 1992: Dr. Peter B. Dews Dr. Charles L. Duncan Dr. Helen A. Guthrie Dr. Alfred E. Harper Dr. Louis C. Lasagna Dr. T. A. MacMurray Dr. Alex Malaspina Robert D. Middlekauff, Esq. Dr. Robert J. Moolenaar Dr. James W. Stanley Harvard Medical School Hershey Foods Corporation Pennsylvania State University University of Wisconsin Sackler School of Graduate Biomedical Sciences, Tufts Medical School H.J. Heinz Company The Coca-Cola Company McKenna, Conner & Cuneo The Dow Chemical Company PepsiCo, Inc. Upon motion duly made, seconded, and, carried the above named individuals were elected trustees of ILSI-NF for the terms indicated and until their successors are elected and qualified. A complete list of Trustees is attached to these minutes. Y
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10 Dissemination of Information and Preparation of Monographs The purpose of this working group is: a) To provide information and documentation to scientists in Europe regarding the activities of ILSI and its branches. b) To coordinate the production of monographs conceived by the working groups and the technical committees. Chairman: Dr. N. Jardine ILSI Europe Staff: Prof. M. Fondu Committees Under Consideration 1. Pesticide Residues An invitation will be sent to member companies regarding the formation of a committee on this topic. 2. Alcohol Following the interest expressed by a number of companies and federations, a meeting will be organized in early 1990. The ILSI Europe Working Group on Toxicology will advise the Committee and follow its activities. 3. Oral Health Problems A first meeting was held in 1989, and a letter was sent to interested member companies. The next meeting at which priorities will be discussed is being planned early in 1990. 0513D 12/29/89
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6 TECHNICAL COMMITTEE ON FIBERS The objectives of this technical committee are: a) To produce and publish a guideline for producers and users of edible fibers. b) To coordinate and financially support research, if needed. Task Forces in three areas were established: a) Evaluation of the caloric value of fibers. b) Elaboration of protocols for the evaluation of dietary fiber sources. c) Evaluation of protocols for the clinical testing of fibers. 1989 Accomplishments: a) An inventory of the research units working in the field of fiber fermentability (in vitro) and on in vivo (rat) studies was undertaken. A proposal for common methods of testing will be suggested for evaluation by those different research units. b) A list of tests to be done on fibers was elaborated, including physicochemical characteristics and physiological criteria. Agreed techniques need to be proposed. Fibers Committee Members Chairman: Dr. J.M. Antoine Amylum Beghin-Say Eridania British Sugar Plc. Group B.S.N. De Danske Sukkerfabrikker/Danisco A.S. Ferrero GmbH Fibrex Hoffmann-La Roche Iranex Colloides Naturels Mars Confectionery Nestec Protein Technologies International Sanofi Bio-Industry Sofania Sudzucker A.G. Sucre Recherches et Developpement United Biscuits D.D. Williamson 6
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Research Awards Program (cont.) Journal Articles Resulting from Research Sponsored by the ILSI Research Foundation Balaban C, O'Callaghan J, Billingsley M. Trimethyltin-induced neuronal damage in the rat brain: Comparative studies using silver degeneration stains, immunocytochemistry and immunoassay for neuronotypic and gliotypic proteins. Neuroscience 26(1):337-361, 1988. Balaban C, Billingsley M, Kincaid R. Evidence for trans-synaptic regulation of calmodulin-dependent cyclic nucleotide phosphodiesterase in cerebellar purkin je cells. Cellular Neuroscience Benton H, Jackson T, Hanley M. Identification of a novel inflammatory stimulant of chondrocytes. Early events in cell activation by bradykinin receptors on pig articular chondrocytes. Biochem. Journal 258:861-867, 1989. Boekelheide K, Anthony D, Giangaspero F, Gottfried M, Graham D. Aliphatic diketones: Influence of dicarbonyl spacing on amine reactivity and toxicity. Chemical Research in Toxicology 4(l):200-203, 1988. Boekeiheide K, Eveleth J. The rate of 2,5-hexacanedione intoxication, not total dose, determines the extent of testicular injury and altered microtubule assembly in the rat. Toxicology and Annlied Pharmacology 94:76-83, 1988. Fine J, Gasiewicz T, Silverstone A. Lymphocyte stem cell alterations following perinatal exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin. Molecular Pharmacology 35:18-25, 1989. Hanley M, Jackson T, Vallejo M, Patterson S, Thastrup 0, Lightman S, Rogers J, Henderson G, Pini A. Neural function: Metabolism and actions of inositol metabolites in mammalian brain. Philosophical Transactions of the Royal Society of London Series B 320:381-398, 1988. Hanley M, Jackson T, Cheung W, Dreher M, Gatti A, Hawkins P, Patterson S, Vallejo M, Dawson A, Thastrup O. Molecular mechanisms of phospholipid signaling pathways in mammalian nerve cells. Cold Snrina Harbor Svmnosia on Ouantitative Biolorrv LIII:435-445, 1988. Hardwick J, Russell J, Kimura S, Gonzalez F, Reddy J, Peraino C, Huberman E. Localization and expression of the eicosanoid metabolizing P4501 VA gene family in rat tissues and hepatic tumors. (In Press). Eicosanoids and Bioactive Lipids in Cancer and Radiation Injury. Jackson T, Patterson S, Thastrup 0, Hanley M. A novel tumour promoter, thapsigargin, transiently increases cytoplasmic free Ca2+ without generation of inositol phosphates in NG 115-401 L neuronal cells. Biochem. Journal 253:81-86, 1988. Ln m Kincaid R, Balaban C, Billingsley M. Differential localization of calmodulin-dependent k° enzymes in rat brain: Evidence for selective expression of cyclic nucleotide m phosphodiesterase in specific neurons. National Academy of Sciences 84:1-5, 1987. N Kincaid R, Takayama H, Billingsley M, Sitkovsky M. Differential expression of calmodulin- ~ binding proteins in B, T lymphocytes and thymocytes. Nature 330:176-178, 1987. McCaffney P, Rosner M, Kikkawa U, Sekiguchi K, Ogita K, Ase K, Nishizuka Y. Characterization of protein kinases C from normal and transformed cultured murine fibroblasts. Biochemistrv and Biophysical Research Communications 146(1):140-146, July 15, 1987.

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