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I n°UJ °n3 Subject: Estimation of Nicotine Deliveries with Filter Nicotine Data To: om Perfetti Date: April 15, 1982. From: D. E. Townsend M. F.. Stowe Lvnn Dube , Use of filter nicotine level to estimate delivery to the smoker requires that the percentage of nicotine removed from mainstream smoke by the filter (i.e. filter efficiency) be known. Since the filter efficiency is dependent on smoking patterns (puff volume, duration, frequency, puff profile, or butt length), the results of filter nicotine measure- ments may be used to estimate nicotine delivery only when measurements of smoking patterns are also obtained. The following data taken from a recent study of the effects of smoking parameters on delivery for NOW 85 cigarettes illustrate how the change in filter efficiency with changing smoking pattern will affect prediction of nicotine delivery from filter nicotine measurements. RSM models developed in the study show that a nicotine delivery of 0.15+0.01 mg/cig. may be obtained with various combinations of puff volume and frequency while the filter nicotine level ranges from 0.29-0.51 mg/filter. Also it can be shown that with various combinations of puff volume, frequency, and duration, a filter nicotine level of 0.5(}+0.01 mg/filter may be obtained while the nicotine delivery ranges from 0.15-0.40 mg/cig. These examples neglect other important smoking parameters such as butt length and non-uniform smoking frequency and therefore should be regarded as conservative estimates. In recent studies, Dr. John Reynolds has observed differences in smoking patterns by age and sex. Since nicotine filter efficiency is a function of these smoking patterns, it follows that the average nicotine filter efficiency differs among demographic groups. Thus, an ad ional source of error may be introduced in the estimation of nicotine'de ivery from filter nicotine values if the sample of smokers is not demographically balanced. Clearly, unless one also measures smoking patterns, nicotine delivery cannot be estimated with filter nicotine data. dd xc: Dr. W. H. Henley Dr. J. H. Reynolds RJRI FORM 2422- Rev. 7/70

NOW EXPERIMENTAL DATA 50906 6 TUBE 0.6 75 P - 70 E 0.5 R C E N 6 5 T I 4 J '~ ~ F E 0 . F m I '~.1' f F g 60 I / C c I 0 3 g . 1 ~ ~~ F N t -1 Jr ~~ _ ~ 5 5 C Y 0.2 50 55 60 65 70 75 80 3005 50 PERCENT DILUTION