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. d ~ I90'a ~,U Mq~ f e ~ o Rockefeer rh o University ~ JOSHUA LEDERBERG PRESIDENT THE ROCKEFELLER UNIVERSITY 9230 YORK AVENUE NEW YORK, NY 10021 Mrs. Eleshia C. Marceau Technical Coordinator Research and Development RJR Nabisco, Inc. 1100 Reynolds Boulevard Winston-Salem, NC 27102 Dear Mrs. Marceau: May 22, 1987 On behalf of The Rockefeller University, and with special gratitude to RJR Nabisco for its ongoing assistance, I am pleased to submit the enclosed report on research ini- tiatives and advanced education that have benefitted from the the support of the Fund for Biomedical Research created by R. J. Reynolds, Inc. in continuing accordance with the terms of the pledge made by the Fund in 1984, we take pleasure in reporting on the use of this Fund to advance four broad areas of initia- tive including: * Basic Biomedical Research, with an emphasis on investigations related to cancer * Cl inical Research * The Laboratory Animal Research Center * Graduate Fellowship Funding from RJR Nabisco this past year has supported basic biomedical and cancer-related investigations that include the examination of the way in which genetic activity is regulated and aberrant processes in canceri the role of interferon in controlling cell growth; and the development of certain hormonally-related cancers. In addition, RJR Nabisco Clinical Fellow Dr. Richard Galbraith is pursuing the poten- tial therapeutic value of cobalt-heme for cases of prostatic cancer which seem to be related to high levels of the male hormone testosterone. Support for the Laboratory Animal Research Center has enabled this group to continue providing essential services to University scientists, while studying methods of toxico- logical testing that may diminish reliance on using live animals to test potentially toxic substances.

May 22, 1987 Page 2 The progress of the four RJR Nabisco Graduate Fellows continues to exemplify high standards of discipline and dedication. Your company's support has allowed talented young scientists to continue to benefit from a unique educa- tional program in which each student helps devise his own curriculum, comprised of independent study, tutorials, and laboratory experience, as well as lectures. Rockefeller is a community of scholars in which the students are simply the younger scholars. RJR Nabisco's support has been invaluable to these and other investigations described in the enclosed report. We look forward to continuing our partnership, which will help ensure the ongoing success of these endeavors. Sincerely, JL:dc Enclosure cc: Dr. Frederick Seitz