Tobacco Documents Online

PLAN OBJECTIVES MILESTONES 1) Assist product development by providing improved knowledge of the sensory nerves and organs which mediate smell, taste, "feel", and draw. Strategy - Relate physicochemical properties of main- and sidestream smoke to sensory and behavioral reactions of smokers and non-smokers. * Review sensory irritation with respect to 3/31/91 ETS. [DLCK, SBS] * Review ETS chemistry with respect to 3/31/91 government standards. [SBS, DLCK] * Complete evaluation and report on odorant- 6/30/91 evoked brain potentials. [JCW, WSP] * Complete study of psychophysical and 12/31/91 respiratory responses of trigeminectomics to selected odorants. [JCW, RAJ] * Complete description of interactive roles of 6/30/92 olfactory and trigeminal nerves in perceptiort` of odor and irritation and in mediation of respiratory responses to odorants and irritants. [JCW, RAJ] Strategy - Develop models that describe the sensory impacts of changes in products that affect mainstream, sidestream, or environmental tobacco smoke. * Complete study and report on perception of draw. [JCW, RAJ] * Complete study of responses of normal and anosmic pigeon model to selected odorants. [RAJ, JCW] 6/30/91 12/31/91 * Combine intra- and extramurally generated 12/31/93 data from humans and animals in predictive model of smokers' and non-smokers' responses to cigarette smoke. [JCW, RAJ] * Complete model of respiratory responses to 12/31/94 cigarette smoke. [JCW, RAJ] a:\plan9l\obj090l.00l ver. 10/31/90 ~ ~. m ~ _.

PLAN OBJECTIVES MILESTONES 2) Improve methods of product evaluation and marketing new products through systematic exploration of factors involved in smoking satisfaction. Strategy - Apply existing or emerging technologies, and develop and implement new technologies for the measurement and analysis of human smoking behavior, the measurement of smoking satisfaction, and the determination of the relationship of smoker demographics, lifestyle, and psychological makeup to product acceptance. * Ensure timely completion of 1990-91 Nicotine 4/01/91 RSM HSB Study. [JHR, RAD, WSP, DWG, DWE, MFS] * Compete analysis, interpretation and 4/01/91 reporting of psychographic, physiological, behavioral and satisfaction data from the 1990-91 Nicotine RSM Study. [JHR, RAD, WSP, DWG, DWE, MFS] * Complete analysis and report of 1990-1991 7/01/91 WINSTON vs. Marlboro puff-by-puff EEG study._, [JHR, WSP, RAD, MFS] * Design, execute and report 1991 Nicotine RSM 7/01/91 Plasma Nicotine Study. [JHR, RAD, DWG, MFS] Strategy - Relate physicochemical properties of main- and sidestream smoke to sensory and behavioral reactions of smokers and non-smokers. * Design, execute, and report an acute-smoking 10/01/91 study of LTN cigarettes. Cigarettes to include nicotine salts; studies to include puffing, breathing, plasma nicotine, and neurohumoral measurements. [JBR, JCW, RAD, MFS] * Design, execute, and report a nicotine and 6/30/92 "tar" dose-response study. Cigarettes to include REST-based, and/or LTN, products, if available; studies to include puffing, breathing, plasma nicotine, and neurohumoral measurements. [JHI2, WSP, RAD, MFS] * Design, execute, and report a long-term study 12/31/92 of puffing behavior, plasma nicotine, and neurohumoral agents. Cigarettes to include LTN products, if available. [JHR, WSP, JCW, RAD, MFS]

Strategy - Develop models that describe how physiological and psychological responses to smoke affect consumer "satisfaction" and choice of regular brand. * Design, execute, and report a study of the 12/31/91 effects of smoking on rapid information processing in human smokers, to include stress and no-stress conditions. [WSP,JHR] * Design, execute, and report a quantified 6/01/93 smoke delivery system (QSDS)-based, dose- response study of the effects of nicotine on EEG, heart-rate, blood pressure, and neurohumors. [JHR, WSP, DWG, RAD] * Develop a model including puffing and 12/31/94 breathing behavior, plasma nicotine, and, if applicable, neurohumoral measurements that is predictive of smoking "satisfaction". [JHR, WSP, JCW, DWG, RAD] a:\plan9l\obj090l.002 ver. 10/31/90

PLAN OBJECTIVES MILESTONES 3) Assist in improving products and knowledge of the market place as a whole by providing improved techniques and methods for the study of smokers and smoking behavior. Strategy - Apply existing or emerging technologies, and develop and implement new technologies for the measurement and analysis of human smoking behavior, the measurement of smoking satisfaction, and the determination of the relationship of smoker demographics, lifestyle, and psychological makeup to product acceptance. * Establish radioimmunoassay (RIA) technique 12/01/90 for analysis of nicotine and cotinine in biological fluids. [RAD, MFS] * Select neurohumoral agents that are 2/28/91 candidates for linkage to smoking satisfaction and establish RIA analyses. [RAD] * Evaluate sources of variability in levels of 4/30/91 neurohumoral agents in humans. [RAD] ~- * Design, build, and test an improved 5/31/91 psychophysiological testing laboratory for the study of human performance as it relates to smoking. [JHR, WSP] * Ensure implementation of new HMSM technology 6/30/91 within Biobehavioral Division. [DWG, DWE] * Design, build and test a quantified smoke 12/31/91 delivery system (QSDS) to administer known quantities of smoke to human subjects. [JHR, BJI, DWG, DWE] * Research and test existing technologies for 12/31/91 measurement of "wasted smoke". [JHR, DWG, RAD, DWE] * Ensure application of new HMSM technology to 12/31/91 development of QSDS. [DWG, DWE] * Complete system for measurement of "wasted 12/31/92 smoke" and apply to ongoing, in-house studies of smoking behavior. [JHR, BJI, DWG, DWE] ~ Maintain--and improve analytical methods for Ongoing analysis of nicotine and cotinine in biological fluids. Provide such analyses as needed. [RAD, MFS]

Strategy - Transfer developed technologies or models to Brand R&D and/or other interested groups within R&D. * Ensure implementation of new human-mimic 11/01/90 smoking machine (HMSM) in Analytical Services laboratories. [DWG, DWE] * Complete technical documentation for new 3/31/91 HMSM. [DWG, DWE] * Complete technical documentation for Puff 6/30/91 Profiler and Calibrator. [DWG, DWE] * Replace obsolescent HSB field computer 6/30/92 systems with PC-based systems and/or develop and implement plan for "portable" HSB field systems. [DWG, DWE] * Upgrade portable Puff Profilers. [DWG, DWE] 12/31/93 * Upgrade flow probe technology. [DWG, DWE] 12/31/94 * Provide support to HSB field measurements as Ongoing needed. [DWG, DWE] * Provide ongoing support for development and Ongoing installation of new HMSM technology. [DWG, DWE] . . a:\plan9l\obj0901.003 ver. 10/31/90

PLAN OBJECTIVES MILESTONES 4) Help in making informed decis-ions on how products should be designed to achieve product development goals by developing understanding of the chemical and physical phenomena which affect the release, transfer, and absorption of smoke constituents, as well as the sensory "values" of constituents. Strategy - Relate physicochemical properties of main- and sidestream smoke to sensory and behavioral reactions of smokers and non-smokers. * Measure and compare chemistry of ETS from commercial, reference, and new technology cigarettes (Multi-cigarette I). [DLCK] 3/31/91 * Complete study of evaporative deposition of 5/30/91 nicotine, identifying differences among cigarettes and the relationships of these to sensory perception and behavioral reactions. [BiI] * Design, execute, and report a dose-response 5/30/91 study of the effects of levulinic acid on human olfactory response. [JCW, JHR] '' * Identify other smoke components thought to be 7/31/91 related to perceived "strength" and that undergo evaporative deposition. [BJI] * Compare human responses to ETS from HORIZON 9/30/91 with and without EVG. [DLCK] * Measure human sensory and physiological 12/31/91 responses to ETS from commercial, reference, and new technology cigarettes (Multi- cigarette IV). [DLCK] * Design, execute, and report a study of the effects of levulinic acid pre-exposure on human olfactory responses to nicotine. [JCW, JHR] * D°sign and conduct experllllent.. ~' ~lent..~ to determ].ne relative contributions of particle deposition and evaporative transfer to perception of "strength"-related sensory attributes. [BJI] * Design, execute, and report a study of the effects of levulinic acid-nicotine mixtures on human olfactory responses. [JCW, JHR] * Determine effects of dilution, reactions, etc., taking place as smoke evolves from point source, on chemistry and sensory perception of ETS. [DLCK]

* Investigate smoke formation mechanisms that 6/30/92 affect smoke deposition or transfer properties found important to sensory perception. [BJI] * Measure and compare sidestream smoke from 12/31/92 commercial, reference, and new technology cigarettes (Multi-cigarette III). [DLCK] Strategy - Develop models that describe the sensory impacts of changes in products that affect mainstream, sidestream, or environmental tobacco smoke. * Develop semi-quantitative, predictive model 8/31/91 of evaporative deposition, based on properties of TPM and aerosol dynamics in the respiratory tract. [BJI] * If warranted, extend aerosol dynamics 10/31/91 predictive model to include lower respiratory tract deposition mechanisms. [BJI] * Complete compilation of sensory responses of 6/30/92 animals and humans to tobacco smoke constituents. Apply to prediction of: a) relative importance of ETS constituents to non-smoker complaints, and b) effects on smokers' puffing and breathing behaviors. `' [ JCW . JlIl2. RAJ ] Strategy - Transfer developed technologies or models to Brand R&D and/or other interested groups within R&D. * Propose and test alterations of cigarette construction to achieve desired sensory properties of smoke. [BJI] 12/31/92 a:\plan9l\obj0901.004 ver. 10/31/90