Jump to:

RJ Reynolds

R&D Library Cards.

Date: 1900
Length: pages
503352501-503355000
Jump To Images
snapshot_rjr 503352501-503355000

Fields

Date Loaded
07 Jan 1999
Request
Minnesota
1int5
Box
Rjr0975
Type
CATALOG CARDS
UCSF Legacy ID
wrm95d00

Document Images

Text Control

Highlight Text:

OCR Text Alignment:

Image Control

Image Rotation:

Image Size:

Page 1: wrm95d00
Molde, Paul, 1900- .. . Tobakken. Kobenhavn, A. Frigast Larsen, 1941 302 1 p. illus. (incl. ports., f'acsims.) cia r ,~ ^ 5z cm. 0
Page 2: wrm95d00
50335 2501 ~ TS ~ ~ 2240 C _..._ Y.. ~.. ,..rIK.. Co111n, K1e11 Tfl$A1C. (Tobacco.) 1963 137 p. P. A. Norstedt & Soner Stockholm ..~..,,,.,.~~ 0 5~ o~~2 4 7 9 0
Page 3: wrm95d00
T(1 BA CCA-- SMnK TNG--P SYCHnLOrY/ 78-'ZAd -7A S.P. "ellar, D. *(no affil.)* 50335 2504 RJR CLASS NO. PAPfPHLET 78 XI Adl s. p. TOBACCO EPIDEMIC ON THE WAY OUT. Tidsskr. Norske Laegeforening 97 (No. 1) 1-4 (1977) (in Norwegian - complete English translation available) 1~-_-- _ ; The smoking epidem ic seems to be in a definite retreat--at any rate 'in the industrialized world. The health-damaging effects of tobacco smoking have een clear to doctors for more than 25 years, and this ' e is now benefiting the population to an increasing degree. knowledg -_--_-- = -- - - _ - --- - "Health education by health personnel, teachers, public agencies, and ,volunteer organizations has led to change attitudes on tobacco and sm oking as a result of the transmission of the knowledge and arousing awareness, and the results are now in: smoking is now declining. 0 5 0 0 0 0 2 4 7 9 3
Page 4: wrm95d00
50335 2505 r, Q "l:'b 0 - ;~p~tOdopSTVoe . .. t- • _ r,...~ :. ..~- .~ a (D ..~s ss+.. 0 5 n o n v2 4 7 9 4 .~------ ~
Page 5: wrm95d00
50335 2502 i TS ,?z4o Is Svenska }obaks ?Jctiebolaget M TG3AK I SVLR'EGE - JUEU.EL'idSSY.E1rT 1g15-t965 'Tobw^co in Sweden - Auni-versary Publicati-Z,3 1915-1365) Stockholm 1965 366 p. - in Swedish ---~--,., 0 S 4. 0 0 0. 2 4 7 :_-9
Page 6: wrm95d00
Yaaumatsu, Katsuharu STUDIES ON TflE ETMiZY?fES PRODUCED BY TRl~i*fETES SANGUINEA (III) Solubilization of Yeas t and Soybean Meal by the Enzymes from Tra.°cetes Saxtj;uiauea, uy KaLsutaru iasuu:aCsu, i;ass::iro Ohno, Masayoshi Tobzri and H3rao Shi*.r.azono. Rakko KogRku Zasehi 44 (No. 11) R47-53 (1960) 11
Page 7: wrm95d00
{~?[Th1) aoua?l3za3ul ~~o~, r.a~t ~G '7.I •i~ ,0~1cl ~b3ua}3S r 18Z ab
Page 8: wrm95d00
jt au Mark, Hermann Franz, 1895- Physical chemistry of high polymeric systems. 2d com- pletely rev, and augm. ed. iby, H. Mark and A. V. Tobolsky. New York, Interscience Publishers, 1950. xi, 506 p. iilus. 24 cm. (High polymers, a series of monographs on the chemistry, physics, and technology of high polymeric sub- stances, v. 2) Bibliographical footnotes. 1. Polymers and polymerization. 2. Chemistry, Physical and theo- retical. i. Tobolaky, Arthur Victor, joint author. (Serie$) Qll281.PG:1137 1950 541.7 50-13210 Library of Conereas "`` I rkIY3j
Page 9: wrm95d00
QD '281 iTo + a 50335 2517 Proherties m.d structl:,e of polyine.s. 1ew York, Wi1zy i19601 i31 li. Elltis. 24 c:uu. (Wiley serier on the scieac,~ and techno`.ogy of mxterinls) lucludcs LiLliogruphy. 1. Polymem and Polcmerizsttion. i. Title.
Page 10: wrm95d00
M ti Ta ~ 1.[,1,9 Mikrosxopiscne untersuchung pflPnzlieher ft.ser T stoffe, von Friedrich und Gertivd Tobler Woiff. Leiyzig, S. Hirzel, 1951. vii., 171 p. 23 cm. o s0- . 0 ~ t~ .2 4 8.,~ z
Page 11: wrm95d00
F$.ItiCIPLES, INSTR(I:lit:3TATIt3Pi AP:D ASSAY f MTiOD OF FLUKrRwa:.Eidti:E Ari'ALYSIS Japaai Aasly8t 17 (No. 7) R78--8 ;8 (.7u3 y, 1"58)--Ia jap8i18$H ' 0 ~~ 0.0 n 0.2 47 1 7
Page 12: wrm95d00
50335 2512 I % Tog NIWT$bi8 Ai~.n? StMKII:G •• $U-U7ICIi'3lL AND DE'IRI29ET~^.L Ec,s r'CTS. ApPI. 1''3ze-vni?. j, 903 t1962? I o s~ 0 0 02 4 8 0 t.
Page 13: wrm95d00
75 X Sz ~-'fC;3~CLYi~=StRIr~FYIG==!~EI:T~'t~L? ;f~i~:~I~C~iiACCO--Si~KFi;G--PSYCIiOLOGY/ SMOKING HABITS--RELINQL'ISI3:iiG/ RJR CLASS NO. PAMP6iLET 75 X Si Sipich, J. F.; Russell, R. K.; ~ (itni.v. Ill., Psychol. Counsel. Cent., Urbana. Ill.; Michigan St. Univ., Counsel. Cent., East Lansing, Mich., U.. S.) - A CQMPARISGIiv OF COVERT SE:dSITIZATI(}N A:~t3) '•'NOI+ISPECIFIC" TREATr1E;1T ':.'.d Tli:: MODIFICATION OF Si•FOKIAlG BEHAVIOR. Jour. Sehav. Ther. Exp. Psychiat. 5, 201-203 (1974) (in English) 11975, No. 1, W 77* *d* acco medici;.e (analys;.s) : - - - ...- i.:... s.-....;.:.._._~_...~ _,~.,...~_~..,..,. ~,-...~..a...,> ,... _< _..,.s..:._._._..~ .
Page 14: wrm95d00
i Organic peroxides: their chemistry, decoinpositioii, aliC role in polymerization ~byy Arthur V. Tobolsky and Pwaer B. 1ltesrobian. New York, Interscience Publishers, 1954. 197 p. tltus. 24 cm. 1. Perosides. 2. Chemistry, Organic. 3. Polymers and polsmeriza-~ tion. L~Iesrobian, Itolxrt B., 1J24-- joint anthor. n. Title [. QD18LO1T6 ~-~ 546.21 54-i234 z Library of Conbress '•...>' 120j QS U.4n4.2 4 ~30 4
Page 15: wrm95d00
50335 2518 ~ s ~~ ~~r} 1L: L~..:: ; ~ ~ ~'`.~~ ~° r~~ To::!j w-!.d W::.ji= Sasoz•. -, Fttb. G`piniLi1 lis 1 U°1,4 A 5 A A n 0 2 48 0 7
Page 16: wrm95d00
LUNGS--FUNCTION & FUNCTION TESTS/RESPIRATORY ORGANS--DISEA! LUNGS•-DISEASES/ SMDKING-AND HEALTH/TOBACCO--SMOKING--HEALTH EFFECTS/ DISSERTATIONS--JOHNS HOPKINS UNIVERSITY/ ia~.tia+-+~e s'n+ai orM~ ru=iam ia Icursyass, PT. 1 & 2 TS 2240 To 1979 by fslti.ore. wr7laod 1979 • dissertatioe submitted to 7be Jobas Hopkins Oaiversity in eoaforrity vitA tbe requirerots for the degree of Doctor of Philosoylh O 500 0024808
Page 17: wrm95d00
. 50335 2511 1~ RJR CLASS N0. PAMPHLET 71 VII To 7,,.2 di Smith, L. W. (U. S. Army Natick Lab., Pioneering Res. Lab., Appl. Entomol. Group., Natick, Mass. , U. S. ) , NOTE ON TiiE i-lATI23G BEHAVIOR OF THE CIGAR~.'ZTE BEETLE (LASIODE.°,I''tA SERRICO=~ ; (F) : A?2flBIIDA~:) . s Entomol. News 82 (No. 1) 23-25 (1971) (in English) *1971,-Ho: 20, W 8475* *d* Tobacco agriculture: . ~ '
Page 18: wrm95d00
Reprint Rodgman, Alan and Lawrence C. Cook THE COMPOSITION OF CIGARETTE St4?KE. IV. a-TOCOPHEROL. Reprint froms Tobacco 1~_O (No. 2) 20 2.1 (Tobacco Science j4, 7-8) January 8, 1960 ~
Page 19: wrm95d00
. . ~ :~.. t , _ . . 1. . . . ~--_ 50335 2506 ~ Y s j '"~!Ellt.Ud--"Spwll~ Y7t5524E/ B.TB cLASS NO. PAMPHLET 74 x S j Sjolin, K. E. *(no affil.)* SNDKAdG - A SOURCE OF LQOAI. AIR POLLIJTIOL lTgeskr. Laeg. 133 (No. 44) 2187-88 (Na.. 5, 1971) (in Cersa:r with i Lasliah abitract) Geoerrl proMems involved in sm<rkinlt. and a;Tn.aches to its abatement are di>cusaed. Jomc lS.Ola) tons rf tWbaccu are smukrd yearly in Ihnmari:, of whtch abuat z3r's causes par- ticulate .ir pu;otiun. annvimting to an emis.ior. of 5300 tuns yearly. With unc-fifth a.f th: towt tuhau:u bcir•,g smoked in Cvpcnhaf-en, the smuking-geuctatcJ air pollutiun amawcts there to IO tnr.s/.y km%yr. Smoking in closed lacals represents health h:uards :,nd r nui.ance fur smokcrs and nonsmukers alike. The 1,J•hcnwupyrer:c cuncentratiun in the nuninhalyd cigarette ,mokr is about thrce timc> aY high as in the inha!cd smoke. Sonic 3tltt•1 cases of premature dcatt occur cea:ly ui Detnark due tu smol,:ing. A retatlUnsnlp pCtNttn 1LLny' e:1:ICCr incWencr and ,mnking was Csi:l6h%hPd. *1974, No. 9, W 3460* *d* Tobacco chemistry:
Page 20: wrm95d00
Deuel, Harry James, 1897-1956. The lipids, their chemistry and biochemistry. New York, Interscience Publishers, 1951- v. illus. 24 cm. Bibliographical footnotes. CoarreN•rs.-Y. 1. Chemistry.-o. 2. Biochemistry : digestion, ab- sorption, transport and storage. 1. Lipids. (; P751.D IJ ~-~+,, f~i4.19°3 51-5776 rov Lilrrary of Congress
Page 21: wrm95d00
50335 2521 ANNALS OF THEyGEw YORK ACADEMY OF SCIENCES Vor.tnn 203 Deamber 18,1971 \ . QP 772 Ne, 1972 RVTERNATIONAL CONFERENCE ONWTTAMiN E AND PTS ROLE IN CELLULAR METABOLISM' Conference Chairmen Hamrxr J. KAYDEN mro PenmANAsnm P. NAm Editors PwDmurtesHeN P. NAa Axn liEnsgaz 1. KAYDEN ' CONTENTS jnleodoetory Remarb. By FitaaOeT J. IGmm
Page 22: wrm95d00
~..~. ~. _- .... - IX Ms..772 EFFECTIVE PROCESSES FOR TF.H OXIDATION OF CO TO C02 S. T. Sutt, R. S. Joyce, M. F. Kranc, J. R. Lutchko, and •- tittsburgh Activated Carbon Division, Calgon Corporation P. 0. Box 1346, Pittsburgh, Pennsylvania 15230 Chicago, Illinois, September 13-18, 1970 Not For Publication . -w-_ - -'-'~' Preslated Before the Division of EJater, Air and Waste Chea-istry American Chemical Society & he catalytie oxidation of carbon monoxide has-been widely reported in the liter- ture.(l,Z) Platinum group a::tals or one or more transition mztal oxides are Snerally„use ls he - e ta st N =~_.. y,g he are supported on c thetmally
Page 23: wrm95d00
50335 2525 Colowick, Sidney P., ed. Methods in enzyrlo2o;y, edited by S{dnFy r. Coln-vick and Nathan 0. Kaplan. New ynrTrP Ararlomirt Pr.•ASt; 1gSS- 40jj r// c~c;v, il3.ue. 24 cra. t/ol, t--iQ p7 /~-#t1I,Q,e,19 d ~
Page 24: wrm95d00
I 50335 2528 tiP 501 Methods of bioclier;.icai analysis. v. 1- New York, Interscier-ce Publishers 11554- 1 v. illus., d3 agra. 24 cm. Editor : v. 1- D. Glick. 1. Chemistry, Analytic. 2. Biological chemistry. r. Glick, David, 1908-- ed. QD271.1lL46 Library of Congress 4 n 0 2 48 1 7 543.8 158k1I 54-723S
Page 25: wrm95d00
113 A AIIport, Noel Lionel. . Colorimetric analysis, by I\ oel L. Allport and J. W. Keyser. 2d ed. London, Chapman & Iiall, 1957- v. illus., diagrs. 22 cm. Includes bibliographies. CONTENTB.-v. 1. Aeterminations of clinical and biochemical sig- nificance. for Lihrary of Caugicas Arizona. Univ. T.ihr. ~ 1. Coloriinetry. i. Keyser, Jnmes William, joint author. [QD113.A A 5$-1977 0 5 t3 0[1 0 2 4 8 1 3
Page 26: wrm95d00
5033S 2529 Fortschritte der Chemic organischer Naturstoffe. Progress in the chemistry of organic natural products. Prohres dans la chimie des substances organiques naturelles. 1.- Bd. Wien, Springer-Verlag tetc.l 1938- v. 111us. 24 cm. Founded and for some years edited by L Zechmeister. L Chemistry, Organio---Period. i. Zechmeister, Ldszld, 1889- ed. QD2.11.FG A C 39-1015 rev* Minnesota. Univ. Lihr s ' for Library of Cont;ress \. jrG4p1it 0 S ~ 0 n 0 2 4 8 1 8
Page 27: wrm95d00
RLn~.~.-rt r, Lj`'.. IJ.jCV L?Z3 Am t:?9 rcot=3 CT£ Tc ^°:: va 4) 3~~"~ .. ,_ , . ~ 9 ~ ° P oT. ..
Page 28: wrm95d00
(BiQ myn;:"eas &"I civt"Pc~tion i i~{~~. 7, 43 ~58 {h';~~ ~ r FO ocr- Ia ioS~.ah ~,=iY~ c.?Lts Fn~~~ t:en~~a4ic.~d 0 5 0. © R 8- ~~ ~;?. 0
Page 29: wrm95d00
50335 2530 ~ QP ; 301 ~ G Goadwi.r., Trevi-n: W&l..;~srLhe and reba:-~-d Kew York, Acadc--ic ~ ~ser 3xs 3,'^.' pa alt:?3e. %°ts em. Izx 1t~c:~s bib~,3cs~~'ai~hi~ao
Page 30: wrm95d00
z4.~dr.~ooo~a 0 '°t~) T saoua ; os s*p a~Zuu~Zod ~T~ apr,v~,Z ~~ 'ZZj~~ V L'3 Z3Jr"v~ -! S~ P
Page 31: wrm95d00
50335 2527 . YITMIN E/CHROlAN/ - ~ j THE CHt1f1sTHY OF HZTtiOCYCWC COYtOUNDSJ Vot ~ ; r w wer8s oP KoNocfRwsys ARNOLD WCISiSERGZS a.> EDMAlD C. TAYLOR - -- , HR4MANS AND L 11I. L®ddaet . um uw= „rLwL a&s, iaNOavm omm o.ma.r ~ ' WrEMSCHROC- Pusz.xwnoN F~d by G.P.EBis zw^n7%am cr CH"arm dHvowYcw MAuS 11iITRllB OP KUP1M APID 7ECM1pLApy CARDQ•F. UWRFD CLVODOId N wH.Ew r s alum ~ ~ S , o -o ~ _ 2 sH[Awmim . sHISEANL . 'rORONIl'O
Page 32: wrm95d00
AJ~-~FaICAN C11E'titICAL SOCIETY/ 50335 2538 73 Callo, R. and Ii Am CANCER RESEARCH. II. VLRllSES. '0 PDDL American Chemical Society radio series, Tape No. 532, Side 2, "Men and Molecules"
Page 33: wrm95d00
TS 2240 (Yideocassette tape) To 1981 KOA 4 TV, Today Show, 7:45 AN, Segment: ANTI-SMOKIP, . K 0 500 0 0248 2 8
Page 34: wrm95d00
~ ~.~q~ l~ZIIY ROZRL~:I3 ~ToO~'" ~cotine.) (A'~crobR o1ogica? cie~etia PFioto3tc:t fSccm: Aeta Hicch3m. Polon. ~ (No. 4) 373-79 (1958) •- In Pol.'4.ah with , 11 ~
Page 35: wrm95d00
11 .. _.,..L.: Sp XI To TOBACCO--GREAT BRITAIN/SMOKING AND HEALTH/ tJR CLASS NO. PAMPHLET 80 XI To- ~; Widdecombe, A.; Hardy, P. (nd .affil.) ~~~PJILTHIEB FUTURE ~ Publications Ltd. 1980, London, 12pp. -0- i . Aaontg the other recommendations is one that:- Taxation on cigarettes in Great Britain should be each year by more than the rate of inflation. increased
Page 36: wrm95d00
STUDIES Q:d HEEIT STERIT,.YZATIQN. PART 7. TtiP.RMAL D?ATii TZHB AS ASSESSED FR.C.K TIiB LIFE-SPAK DZS- TRIBUTI4Pi Od' MICS4BBS Jour. F.rmeotation Ttchaol. " (No. 9) 743-752 (1968) ~ S t3 t3 ~ Q2 4 8 -2 S I'll, I _t.
Page 37: wrm95d00
L'analyse des ,~ M r dans les -huiles vegetates ` par 16 cherars-ea~~yi-aphie liquide haute performance. 81 111 ^r1 pev. Fr. .-rps 8r&s 27 (6) 279-12 (19M) . P. DB.OMYE. ti 4.MYM Y. 9i"l, a Wfeam S.rvioe da Qwria Jln**qw iw*w des iwdavi.s de ft aataEMioin ^ b+stitut AAwior CM+w - Cf.N,t.4llw.nua E GryroR 1- 107Q bMnadks - lrSWIr C. tisvai a 60 ais .n ow+e .E "i aous r oonduiw du pofm.nr Paui Dddieat doat nous Wett" /e d6cis sub'c 9:t 1fi2lt. Aaini. .t t.e.phs..t: k. v~aget.~i. .ila~ ..itlNn~ oe+U+r treat.e~ 4it)i .~w used .n the .tatiaa.rp plare:•• bi~ srt..n.a. It,t.it eb ....t .1Y. t?.iis.., ..itlh 4Mruee cae~t ~'R Vt oAe n` R. . Letai.~rr. G.• s.~.. Y~ w. .~1 ~tr~t. tnd, Pe*m.arst;ne, '~~ A ~ eec«~ ..a w.d. tl.irg tA» . a.e~, ~ tAa. ~= ~..~u. ~ t. ~.1 ~i,q,t , he ~ Fi. _ Ca. t .pli.^+l [~-!} +r.w detd in .nnM.er a, and : Pr ~ 14 . ch.aa~atas 27l-a= OiV t!'r1. Rapid qnd. ~!! a.d ioestrieaois srean de1A& in p.b= ad. TNe, Q~ ~/~ ~ aod Mootsiea0is ws obtaie.d b~r spi~.y .eMati.~e aad detected tooopl~eroi~ in tlre ppo his6-v~er(as..ce ~ !r-i-P%fwwd1"Mww
Page 38: wrm95d00
50335 2541 SMRING AND HEALTH RJR CLASS NO. PAMPHLET 76 X Al Althafer, C. ~.. ; ~ •. : - ~:. _ (National Clearinghouse Smoking Health) *Abstr. ins Sunday Journal 1975, p. B-5 (Dec. 14, 1975)*(in English) National Clearinghouse Smoking Health, News Release (1975) (in English) _ , ~, -_.• .~ t-Y. .. i ' ' ' . . . ~ : .: Y - ,. _ . .. _ .. . ~ ~ .
Page 39: wrm95d00
50335 2544 i Perspcctives in organic chemisi.,y. New I ork, Inter- science Publisheis,1956. x, 527 p. coL port. 24 cm. Publ,'shed on the occasion of the 70th birthday of Sir Robert Robin- son, September 13, 1956. Includes bibliographies. CowrEvrs.-The nature of the theory of resonance, by L. Pauling.- Reaction mechanisms, by P. D. Bartlett.-The development of the concept of aromaticity, by W. Baker.-Stereochemistrs, by D. H. R. Barton.-Bedeutung der vielgiredrigen, Riiigverbindungen fur die theoretische orgt,nische Chemie, by V. Prelog.-B:osynthetic theories In organic chemistry, by A. J. Birch.-Synthesis, by R. B. Wood- ~"` `~, (Continued on next card) ~ 56-10319 `~" I57a201 c~5oa a 0.2 48 3 3
Page 40: wrm95d00
50335 2546 ~ Ref. Q ~ 123 Wa THE WATER F.~iCYCIArEDIA, A Comgendi= of Useful Inforuation on 4ater iteaources 1970 559 ra;es Water Inforraation Center aew York ~
Page 41: wrm95d00
vi To, 1.' ;3` a coa~..°'oI ~.nn tobacao. „rla:~.: }~."•x"`Lh lq.550
Page 42: wrm95d00
._ . _.._, 75 VII To TOBACCO--DISEASES. AND PESTS--VI1tUSES/ TpBACCO-_iHpSZIC'VIRUS/ ~ X.1B CLASS NO. PAMPHELT 75 VII To (North Carolina Extension Dep., Raleigh, N. C., U. S.) ~ LA cv v, WASHING HANDS IN.AjK INHIBITS TOBACCO DISEASE. ~ N. C. Extension Dep., (Todd, F.) News Release, Raleigh, N. C. (1975) ° (in English) *Abstr. in: Dairy Record 1975, p. 13 (Feb. 1975)* `n *1975, No. 5, W 1544* *d* Tobacco agriculture:
Page 43: wrm95d00
7->:gEx:L*-snts on tobaceo blua P31eig'a, ik-,r'jy C,arrol `ra Sfiate 19.5$. PJorth Carolina State College Tobacco Reprint Series No. 6. Reprint of North Carolina Agricultural Experiment Station, Technical Bulletin 111. 0
Page 44: wrm95d00
RJR CLASS N0. TEXTBOOK TS 2240 To 1982 FLUE-CURED TOBACCO: 1983 CALENDAR - PRODUCING A HEALTH CROP. See also ISN=4525 Virginia, North ~ South Carolina edition Tobacco Consultants, Inc..Wendell, NC:82.(IN : ENG.) ISN = 6272
Page 45: wrm95d00
1907- ed. in organic chemistry. 1956. (Card 2) CoNTzxTs-Continned. Perspectives ward.-Neue F.ntwickiungen der metallorganischen Synthese, by K. Ziegler.--Carbohydrates, by E. I.. Hirst.-Nucleic acids, by Sir A. Todd-Beeleutung der theoretischen organischen Chemie fIIr die Chemie der Terpenverbindungen, by L Ruzlcka.-Steroids, by C. W. t3holmee.-Alkaloids, by F.. Schlittler.-Isotopes In organic chemis- try, by J. W. Cornforth.-Dticroorganisms in orgaulc cheuuistry, by K. Folkers.-Cheinotherapy, by J. 1Valker.-Organic chemistry and conifer taxonomy, by H. Erdtman.--Qrganische Chenile und Genetik, by A. Butenandt. 1. Chemistry, Orgunia-Collecled works. 2. Robinson, Sir Robert, 1£3t1(1- i. Title. (,1,n245.TG () 5-17.0`32 56-10819 Library of Con„ress ~ it'i7z?01 o s o o n 0 2 48 3 4
Page 46: wrm95d00
TION OF ITAMIN B/PASTBtW Louisf i NC NZ F ME U Y 1 s ~ ItIBERI AI+TD THE COE ANDS, DUCTLESS (DISEASE, OF) /SICKLE CE~I. ANF~tI~i/~tYE~A ll~d TRE STRUCTURE OFvAt@TIBODIE ESSAYS ON PATHS OF DISCOVERY IN THE , /B1OMEDICAL SCIENCES WfM ftb%cado^ mo. (IH$ s 2.4 ' , ; aa~a.v~anE JUDITH P. SWAZEY u pubic Hsakh Servion NoWnat Misatutes of Headh AND. . KAREN REEDS ' Prepwed Under Contract NO1-CO•55315 Q 5Q 0 0 0 2 483 2 for dw Nationol Canar Institute
Page 47: wrm95d00
50335 2542 i T 175 Chacko, Gzor€e K, Ch TODAY't S Lw rQi'nfA'IICN FOR T0MARRAW= S PRODDCTS a AN OPE1tATIfl;aS §~,ESEAR{2i APPROACH 1966 225 pRges Thompson Book Co-zVanp Washington, D. C. ~! ~ 0 00 0 ,2 4 8 3 1
Page 48: wrm95d00
I~o~i`o~ Ez L~ ,T ,~„ ;~ EL$CK SO~~K ..~~S ~ ~~~E FT., tT~'•CURr.i t-~ A 1 T7 T03t~CC0 ?:5 L~'r'L~~+Cz r; B'~ Tvi,; tn tCs. TO CERT~11'`ii k~R~wl'I`TC ;:r~::;!TCDES~ Ly E. P. ti. ~ra1sC ", ". k, T;~;d and E. E. ~goora, : ~ ; Iro. 30. C2aytJn• To'~acco R~,p1 ~ r=t ~ :r_as, ! 5 (tYo. 10) Fhyt^T,atilclo~f Reprint (October 54'1"5u \Jcta b3r 1~flL>i ~ #
Page 49: wrm95d00
50335 2537 ' Ftcc1 52 (2} ,°j-104 (1973) r• ` /CARB01d--THERAIODYNAMICS/ I To ~.a s tuc~~r Uy density ~n iaas~~~`~~i gcs in pore structures of coals chang ' with heat treatment: Part 2. Micropore structure 1Ystinrwl Researrh lnstitute for Pollutiun and Resources, Kawaguchi-Saitama, Japan (Recrived 7/ Vo ve: nber 19721 thanges in micropore structures of six Japanese coals during heat treatment up to 12Q0°C were fotlowed by measuring densities in n-hexane, in methanol and in helium. The mkr)pore volumes were deduced from the difference between the reciprocals of the densities in n-hexane and in methanol. The concept of the 'crystallite' was used in discussing the micropore structures of carbonized coals. Changes in the micropore structures viere explained in terms of evolution of gases, change in the orientation of graptsite-4ike layers, shrinkage of the structure, and so on. The different variations in miaropore structures with heat treatment, between lower-rank coals and higher-rank coals, could well be accounted for by classifying the lower-rank coals and the higher- rank coals as non-graphitizing carbon and graphitizing carbon respectively. It is suggested that for coals and their carbonized products the entrance diameters of the micropores located between the crystallites are smaller than the diameter of n-hexane molecules.
Page 50: wrm95d00
VII To2 bjuo mo1 d and a n+Jzracno fm3 con~t~~ r~'~ ~r .~.a r; , ~.c~r`bkt Caro~.irta StF- te I 9 0 050.0 t10.24ii 44
Page 51: wrm95d00
.73 RJR CLASS NO. PA.`4PHLET XI N04-73 Collins, [d. K.; Hawks, S. N., Jr.; Kittrell, B. U.; Robertson, R. L. , IWO:; Watkins, R. ~ ~ (N. C. State Univ., Raleigh, N. C., U.S.) a , qq (~ S TOra.ACCO ImR:qATIO:i FOR 1974 ~ ~iorth Carolina Agr. Ext. Ser ., Pub'lication No. 108, 59 p. (Dec. 1973) ;c;glishA0 *1973, No. 23, W 10318* *d* ~ 5~ 0n 0 2 4 8 4 5
Page 52: wrm95d00
7& VU ~-80 Phytopathology 70 (7) 693 (1960) OdS[RfATIONS Of THE LXTENSIVE 1979 T01ACC0 81UE MqLD EFIDE.tF1C. Harvey M. Spurr, Jr., \ortA Carolina State Univ. and USDA-1W T acco esearc ., Oxford, %C :7565, andqm~ 5• C- State University, Iialeigh, tiC 2?650. The worst North American tobacco blue sold field epidemic occurred during 1979 resulting in a 252 >tillion dollar loss to growers. The epidemic spread generally from south to north favored by ample inoculum and unseasonably cool, wt weather. tn Wrth Caroltna, burley losses were 40% with say fields completely destroyed and flue-c'atibaceo losses were 4~. Systenic infections were abundan in burley which resulted io severe ctuntin=. Conidia produced by the fungal pathajen 1er~erora Labd•~i+ia were typical. Oospores were ab4pdant in 1taves and systemically infected stems of burley. They were less abundant in flue-cured tobacco especially rlnen 1oca1 leaf infections were arrested. 0 500 0024843
Page 53: wrm95d00
50335 2550 S 40 0 e1 C. TOBJ4CtOn-DISEASES AND PESTS--CONTWTOBACtI,I- AIRICULTURE/ TOBACCtkTHARYESTIN6/TOflACCO--CURI*/TGBACC© MOSAIC VI RUS/ TOBACCO BUQtORM/TOBACCO BLACK SNAtK( ' TOBACCO--MtElKETING/ 1 FLUE-CURED ~rs4 6 M BACCO - PRODUCING A HEALTHY CROP By FIot Edltloa: 1951 Tobacco Coesultants. Inc. Plrofessor Emeritus Route 3, mos 134 Wendell, N. C. 27591 North Carotina State University A 0 ifbktglO. lQo?tlf &t?ona
Page 54: wrm95d00
C~~-iICAL TI:CATM.SI'1'S FC% TBE CCtMICL CF WSi.X.i. AND DISEASES V TOBACCO FL?i:~T BEDS, by Furnay $. Todd and E, E. Clayton. North Cnr olina - St.at© Colleqa Tobacco Rsprint Seriea xdo. 19. Ma rch 1956 23 p, Reprint of North Carolina C::r3culturul Expara.zcont Stationt Tochnical Bulletin 119. 0
Page 55: wrm95d00
VII ~ I,Jo g wa--y--m ~ : Control Tobacco Black Shank. N. G, Acrico Fxpt. Sta.' Fxtension Service A43sar?3 noou~ "foI<?cr" : nd atl.cr p+ablicat3o„s on tobacco Ig58..dsLe. Inccmplete. d a 5 0 0 A 0 2 4 8 4 8
Page 56: wrm95d00
50335 2557 Tre4t~awt of to~.hwtcco pit~~ bed So ~ I S w~i1h Ae.thyl. 1~w~de j.. V.Y I R 4- Jiww r+/Ki Cr 6- 14443 ~p1~i,Cthj Vbw'~'11 Caro~rAq Slste.Cof/!!Ss pgric(tl~ikr+~! t1r'~~ M"* 5Uf;ew). 1434. North Carolina State College Tobacco Reprint series No. 22. 90 f.. r !7 900 n024 8 4 g
Page 57: wrm95d00
50335 2560 :V II ; Nog I .A Cropping Sys `.er.0 i or Nematode Control and Tobacco Productiol1. N. C. Ag;-ic6 E=t. St.a, arlzte."ion. Me-m-ice tSI~~~:,L;:'EC~r PLrLIC" ':'IGIvS o 1~,:.scollanaous "foldcr" urid other pub-Iyaationo on L„atxscco I95R-date. Inaotnp? ete. , Q S 0. 0 0 t~ .2 4 s 49 ~
Page 58: wrm95d00
335 2565 RJR CLASS N0. TEXTBOOK TS 2240 To 1981 EVALUATION OF TOLERANCE TO A BEHAVIORAL EFFECT OF NICOTINE. Doctoral dissertation. University of Kentucky. Lexington, KY. 1981 University Microfilns International.Ann Arbor, Michigan.81. ISN = 5473 0 S 0 0 0 0 2 4 8 5 4
Page 59: wrm95d00
50335 2563 Bennett, R. R, FLUE•CUREB TOBACCO VARIETIES IN NORTH CARCLT."lAy by R. R. &3nnettp S. N. HBvka# Astor Perrp, and Furney A. Todd. North Carolina State College Tobacco Repr3nt Series No. 28. December 191!5 23 p. Reprint of North Carolina Agricultural Extsnsion Sarvice Extenait-n Cir- cular 302. 0 500 no24852
Page 60: wrm95d00
Fa? 1. C;L7-tcu'al Prs.c tic2s for Ner,atode Control in Tobacco. -1'7c,t. Jte. ' Exte^sion ucrvi.ce . i.scell-:nooils "PoldGr" ~:^3 o*,fier publieat.i.ans .~.+Ua~be. I 'soC.~1E.'i.e• h~ VV ~.•~ ~' /~.•~~,iJ(^4r,,A '1 AII•-~~J r.L ~ yy` 0 o s a o n o2 4 8 5 0
Page 61: wrm95d00
ro To L972 Statistics of sm©~g in the United Kingdom Meod by O.-P.-Waft o.B.r-, 3a.A, - Dimhor, Tabaaa Rsnmwb Coxncil RESEARCH PAPER I, itI1 eetllm TOBACCO RESEARCH COUNCIL : LONDON I972 0 © F -F 0 5 0 0 00 2 4~ b~
Page 62: wrm95d00
X To R3'R Class No. PFlmph te,t r7 Cohort analysis of cigarette smoking and of mortality from four associated diseases TOBACtA RrSEARCH COUNCIL by Occubional Paper 3 Honorary Research Fellow, LONAOtt 1976 Department of 1Kedical Statistics and Epidemiology, London School of Hygiene and Tropical Medicine. P.N. Lee and M.J. Wilson Tobacco Research Council Tobacco Research Council "Cohort analysis" means an analysis In which the basic material is classitied by the year of birth of the subjects rather than by the year in which the event of interest (such as death) happened to them. This pa r esents analyses in cohort form both of death rates from the four ma3n c~axaovQsct!'iar2and rApfialry diseases, namely, heart umulative
Page 63: wrm95d00
VII To. SO 1 I OCA ~qa IMr1 Re.tasto& rantrel i rn '6sbQcco -Tqabl c~ ,~, ~. Ftrsasso.. 1~,ele igh~ lMOrtl~ Garo/,nq ~ fa}e Col 1fls of Aspicat-4ure. CJfSL1Z~t7Li~ ~~L„ 4N-d ISp •7- 4S3 0 0 ~ 0 2 4 ~ 5 3
Page 64: wrm95d00
~~ b~0 U 0 05 0 aS6t •zK=Ocl •d Uv JV-t;INM QO$84OV-,,3 (FeCTAW) •sAS~,,,• i2O;£G2"y.i.~ 80"`..Ll OQr+B';TQ'J 0^'YrY'J 'J 0 I'I `WDS "2 OH P= •mv.T, ey ia='y O""-" ..-"9Y 9140="Cl 'OQ Oa eg a`t 11=119 003'raoli
Page 65: wrm95d00
SPWW HA@ITS--CANADa/ XI Mel-8A S.P. xJA CLASS No. TAMPIB,ET XI Me1 80 s.p. (London School of Hygiene and Tropical Mediciae, Dept. of Medical Statistics and Epidemiology, Honorary Research Fellow, London, m.glsacd) AN ESTIMATE OF CZ6AR$TTg CO[iStJWTIOK BY SEX, i68 AND COHORT IN CANADA, 1921-75 London School of Hygiene and Tropical lsedic3se 1978, p. 36 (1978) (in English) . I bad tr.. Ctuf turN.~w tObs lsWtoA to .pp•ed ..# f!M t• Saptret..•r 1977 ls tIN Mpart..•wt ot Stattsttas of tA. CAtversfty of t+rrrloe t• Ont.rlo. Ca.ata. 1qtls• lb.ro, i assoabla4 .bat sc..ot to be ltto wt nralt.tte act oi aaswyltvas b6Tel~rodld'bo s+4t abottt tbe eorrso that efCaratte swo4/s= by seO ,.:11t1 s4rxti ot,lltfteprtt aCes ts Caaa& Aaf talea d.rlwR Me tast 50 Years. ?}1ry0 .ra~ypttnos. hare br.•a cwrertaA fa thls paprr tM" a pru.tst..oai -tlnate o! eiLaratl. .ame.u-.ptt.m by aea, a5. and c.•itort. 0 so' 0 0 0 x4 6 sa
Page 66: wrm95d00
76 V RoI N at u re, re i 1 ove r-w itti New Times, 1976, 45-52(6-11-76) low in- m Rs , =DRAww , . s By Ruth Rosenbaum FLAVORANTS--FOOD/ ili) two They call -hem creative fla.• r- flavor; imitation coconut flavor that 'Iatstes more like coconuts than ct.,.cr nuts•"; three sp,-..ies of artificial potatr, flavur-"Euroµ.-n f3intjr. green earthy Idaho .Intl popular King EJNard".... Though natuic still clutches a few last xxrits lthe flutuc and Au1or of Ere,h- bakeJ hrc:tJ and Irrsh-4nound coffee are the most clu~i~. 1 it cattnul he lone hrf ~rc the rcmainin> .-uuouch, I cdtLlrs are trwtsfurtuerl ht dhc aldhctttical [N~~krrs that be. flavon :% have et.•tt m:tn.tpri1 to nryunil tc.i.urc with their an L, ni rruted tumat . mr.d r.uu .,,maltt paur artful mix of chelnical5, mastei- flavor;sts are no . reproducing the taste of just about E-:very food. F. 1 most Amerlcans, a favorite meat or veclFaahle may soc ~r: exist only .-t: an essence 0 S © 0 o 0 ; ists In the entire world tn.:re are only 13 great crcative tlavorists and no rct:re than 150 uthers who have µhat it takes It, bm. considerctl part of thcir select so- ciety. Shielded tr-..m the puhlic cyc. these hteh priests ut he mult.million -dut- t.tr flavur induwt y invoke the cht n.i- cal elements and create from them the counterfeit flavorn,hat arc in three-quar- ters of the protlncts on our supermar-.ct ....... shelvcs. Advertisements in food industr- journals boast A their mastrrpicces: fake chocolate fhtvt., that tastr% and srnrlls just like "the dark cxpc:nstvc stuff r-.t.1c (rum imported ;uuth American cocoa lk:ans"; synthettc chicken fla~ur that "feclt more 1ik.• chickzn than any uthet ti~k f ~~t Out~ -ve vcr tasted"; {hlttft t15: b!t:lt" ih,it:-tiun strawt`erry
Page 67: wrm95d00
50335 2572 TS 2240 To SWrxun„~, G:. ..,~ ,~ ...-..s ? _.. ~ yr,.T .'v tisa~.'i!... •t±{~'TL-1~ l a ~ u .. _.._.~•.... ~..I...~ ~ + t.l.. i?a:IT:.{Editcrs: Ge F„ Tc: l and 3e T. Law St:::A?`•i^ ~.'OM', . . 0 5 0 0 n 0 2 4 8 6 1
Page 68: wrm95d00
0 . 50335 2570 . SMOKING HABITS--S(1CIAL CLASS/S`tOKING A.*ID NEALTH/TOBACCO--"SrtnKIN(',--HEALTH EFFECT/ STATISTICS--HFALTH/MORTALITY/TOBACGn--CONSUMPTION--GREAT BRITAIN/ TOBACCO--GREAT BRITAIN/ 7 7 X to RJR CLASS NO. PAMPHLET 77 X To (Lond Sch. Ityg. Trop Med., Dep. 'Med. Statistics Epideniol., London) SO CLASS VARIATICNS IN CICARETTE S:1nKING AND IN I10RTALI!ZY FROM 4SSOCIATED D ASES. obacco Res. Counc., London, Occasional paper No. 2, 31 p. (1976) (in English) buring the 10 years from 1951 to 1961, the social class gradient 1 of lung cancer in men increased substantially, and in 1959-63 the class V S.6t.R. (148) was almost three times that of class I(53). !'A smaller social class gradient (from 83 to 131) developed between 1951 and 1961 in the lung cancer S.M.R.'s of married women. On i,the other hand, until almost the end of this period, there continued !to be little change in either sex in the cigarette smoking levels of e different social classes. After 1960, a marked social class `g~adiLnt 9. cQcaAte'tons~mpYiott•'de3loped in both sexes, but even
Page 69: wrm95d00
125 2240 To R, 4 ' CGrr: 11'. t ^ F. . ~, ` ;1 td0 I ' ~CS G' `-' ~. ...;:,. ~ 71/'41Nj:-w CiLj e ~ l~"T I ..+"'`• ed. Ol p• 17JQ r 'i ^)7a cco vsenu:'octtlrzra' R tr3r.r {na Ce^.mit ~r: ~ Grtsat F~ritsitir London `7"' e&. 1 a3, ~iqL p• I~~a .3 c. osa.on0_2 48 .6 2
Page 70: wrm95d00
50335 2575 i.`t?bdc-co CoL'Ac{ Z (Great Britain) (t , F. 'Podd, ed. ) ~Q .. ABOUT ..,'^"-"^ ~;~.~TrI1"17 I i t GF STA1 Z.~:~`TS AFiOLi :3C,'PLLME#1`iA:C" REPORT. ayvfi 4 ; Y:. Tobacco Res. Council, Res. Paper No. 2A, Lcndon, Engla: 3 0 9 0. 0 0 0_ 2 4 t3 6 4
Page 71: wrm95d00
50335 2566 SMOKING HABITS--GREAT BRITAIN/TOEACCO--CONSIMPTION--GREAT 13RITAIN/ SMOKING HABI?S--MM/SMOKING HABITS---WMMM/CIGARLTTES--GREAT BRITAIN/ CIGARETTES--TAR & NICOTINE/ TS 2240 RJR CLASS NO. TEXTBOOK TS 2240 To 1975 'Pb . •. :~ . . _ , . - . . . _ _ . .. . 1975 (London Sch, Hyg. Trop. Med., Dep. Med. Stat. Epidemiol., London)' ' English) C)iANGES IN• SMOKING PATTERNS IN THE U. K. 'obacco Res. Council. London. Occasional Paver 1. 68 v. (1975) (in *Keywords:* nicotine,'smoke, constituent; . ' tar, smoke, constituent: . 4-5 0 fl..0 0 2 4 8•ss
Page 72: wrm95d00
MEDICAL STATISTICS/f,RF.AT BRITAIN--ST.'.TISTICS/SMOKTNG & HEAI,TH/ CIGARETTES--FILTF.R/FILTER-TIP CIGARETTF.S--FILTF.RING ACTI(1N--HF.ALTH ASPECTS/ STATISTICS--HF.ALTH/S?KOKING HABITS--GREAT BRITAIN/LITNGS--CANCER--MORTALITY--EFGLAND/ HEART--DISEASES--STATISTICAL ANALYSIS 0Ff6CCURRENCE/ALCOHnL CONSUMPTZ0~T/ Report on a second retrospectivel~ortalitq studq in North-East Eneland TS 2240 To 1977 PART I : Factors related to mortality from lung cancer, bronchitis, heart disease and stroke in Cleveland County, with particular emphasis on the relative risks associated with smoking filter and plain cigarettes G. Dean' A,J. Wicken. P.N: Lee 0~ 0 0 n 0 24 8 6 5 SEARCH PAPER 14 PART I BACCO RESEARCH COUNCIL: LONDON 197 ~-
Page 73: wrm95d00
50335 2579 CRE"KTSTRY, A*TALYTIC--MASS SPEf;TRt)METRY/ D111/Il Fl A6C/AgASS SPECP690ld4FFl:Y ic 451 Pr 1978 Volume 5 Edited by Q. PRICE Departinent of Chemistry and Applied Chemfstry, University of Salford cl L= 1HEN London • Philad.fph7a • Rheiet and
Page 74: wrm95d00
R.TR GLAS S 2t0 ."PAMF"ilLTsT $I Me, -79 a. p. (haradtfa Srh: Hyg. Tzop: Med., Dep. Med. Stati.at -Epidemiol. , London, -Gt: ',~-~ - . . . . ! ~ • A ~ ~ .Y ~ . . . .. . . . . • . . . . . - . . . . .-. . . ~. t.~ _7~ '~ ...n -CIGARBTTE CQNStMPTI013 PEt ADULT OP . RiC9.SP.X IN VARIOUS COUNTRIES. yJour.. Epidetetiol. Coaimua. . Health 32, 289-93 (1978) (in English) ~ suu.u"Y Estimates or cigarette consumption per adult maie and female available from surveys in cigM eountries are examined and the figures of national consumption per adult implied by the surveys are compared with national averages obtained from government data and other sources. ~ The errors i'ikeiy to be found in the surveys are considered and corrected figures are calculated. ~ Estimtes are also made of ciRarette consumption per woman of childbearing age. 5- 0 0.0 -0 .2 4 8 5 6
Page 75: wrm95d00
5133f 2i'lI TS 2240 T Tobacco ~'•esearch Council (Great Lrftain) (G. FD Todd,cd•) C'M'1.~?ET3'iE C!ARACTISTIGS IN ???E LNIT::D - : I C: hS~ SL':J:~i AFzZiCA, AIrZ~ Ai1STF'r1LIA. Tobaccb ReEeaAch Council, Reeer-rch Pnpars rto 0 5 1963 15 p , Tob. F.c:s, C:uuncil London, Fingland 7 1 ~ 0 5 0 0 n o2 4 86 3
Page 76: wrm95d00
50335 2583 TransLation Grebennikova, A. P. MEASUREMENT OF THE CONDENSATION AND COAGULATION GROWTH OF DROPS OF HYGROSCOPIC SUBSTANCES IN A STREAM OF AQUEOUS AEROSOL, by A. P. Grebennikova, 0. M. Todes, and V. A. Fedoseyev. Translaion from: Kolloidn Zh. 24, 408-18 (1962) 0 SA.Qn©.24872
Page 77: wrm95d00
Report on a seccnd retrospective mortalp study~ in North-East England PllBT, ZI. . Changes in l~iag cancer aad br'oachitis aorta],3ty aad ia- other relevant•tactors occurring in areas ot North-East England 1963-72 RE~BARCE P4PE8 14 PART II ~' "'"'jACCO RESEARCH COUNCIL: LONDON 1978 Cs, Desa, 31.D,.; F.R.C.P., F.1.C.P.I., F.F.C.M., The Nedico-Social Research , M.A:, O.B.E., London School of Hyg3ene and Tropical ]dedicine A.J.+ticken, X.A., Research Surveys of Great Britain Ltd ~ -- . --- -----~-~ W
Page 78: wrm95d00
Condensed patent piactice. 1st ed. New York, 1954. 12 1. 29crs. Includes bibliography. 1. Patent laws and legislation-U. S. i. Title. Library of Congress Q~' c~ Q t~ Q 2 4 8 1~ 9
Page 79: wrm95d00
T+,vdcC`J RC3881.iCti CClZLicll ((ire?t PTIt :ti2} . TGSJfiL:^C ke3e?iCr! ~,'Q:iI1Cil :'{ :_.^r'C:1 P&yft:ZS f:a. 6. 3 8 P. Tc•'v-~co Res:r rci7 Cot.-aci2 i.cmUon, -Er,R23nd +s..«s.~ K . . . .. . .. ~r , 0 5 p ~ q 02 48 6 7
Page 80: wrm95d00
RJR CLASS NO. PAMPHLET VIII ttal-?t, Company KG, Hamburg-Bergedorf, Cer. - with photos. Hauni-Werke Korber Co., Hamburg-Bergedorf, Ger., 5 p. (1974) (in
Page 81: wrm95d00
TOBACCO--BLENDINGS/ CIGARETTES--ORGANOLJZPTIC TESTING/ _..,, RJR CLASS NO. PA:`iPH1.ET 74 VIII Ge Georgiev, S.; ~; Yazadzhiyan, E.; Zhelyaskov, D.; Tsonev, I. *(uo affil.)* CO MBINED USE OF ORGr1:'30LEPTIC ~;iICAL DATA AI3D ELIML*:ATI0.1, LIMITATION, COMPOUNDING OF CIGARETTE BLENDS. `iD INTERAiA:7GI:.G OF SOME TOliaCCO COMPONENTS IN Nauchn. Tr., Vissh. Inst. Khranit. Vkusova Prom., Plovdiv, 18 (No. 3) ~ 97-305 (1971) (in Bulgarian - complete English translation available) _ *i:eyvords:* nicotine, cured, constituent; , proteins, cured, constituent; .sugars, soluble, cured, constituent. - I
Page 82: wrm95d00
S L9 d Z 0 U 0 0 5 p ...:.~:A: Sa9£1 0 "iT`TT (g #011) 7+9 91'TiINS '•~i3u 'lvAr.am H3 9852 SEEOS
Page 83: wrm95d00
PROl3UCTS / TrJBACCO--lLKALOIDS--BIOSYNT!iESIS/CHRO?IAT(GPAPRIC AY.'1LYSIS--LIQUID ChROMATOGRIIPHY TS PSYCHOLOGY, PI•IYSIOLOGICAI/SEABORG, GLE.N T. //iiERKER, MILTON/ Q_F~ MILLER, NEAL E./LEE'~E, EDT~TARD/ KIR.~CL~4ND, J. J./ 973 RJR CL.tSS ?J0. TEXTBOOK TS 2240 Fi 1973 1 liorris, Philip, Incorporated, Richmond, Va., U. S. PROCEED0GS THE FIRST PHILIP :4ORRIS SCIENCE SY:1POSIL'M, RICIZIOAtD VA., 1PRIL 26, 1973. Morris, Philip, Inc.,;lev York, N. Y., 1973, 134 p. (1973) (in English) ~ *1974, No. 5, W 1578* *d* Tobacco chemistry: A 0 500 no24"#370
Page 84: wrm95d00
~ TS' ~ 1109 C Cole. Ea 3. MLP AaA 3'AP>~t tt,'_LL It,riTftl7t~?'ATx~'~y +~r E& 3,, Colo und t4, T add. 195? ].3.7 p. Lccixood Tx-ada Sm-mal Co,v Iuc. I'•tew York ~~ o o t? 0 2 4 8 7 1
Page 85: wrm95d00
VII Re -7~ _7_S ~~ RJR CLASS NO. YAMPHLET VII Re6-77 s.p. `(Tob~acco Res. Bd. Rhodesia, Salisbury, F.hodesia) DETERMINATION OF METQBROHUR4N RESIDUES IN AIR-DRY TOBACCO BY GLC. Confidential Manuscript to be published in Beitrage, 6 p. (1977) (iA nglish) *Keywords:* metobromuron, tobacco, additive. 'Netobromuron is hydrolized in alkaline solution to p-bromine-aniline. This ~,fs extracted into i-octane in the Bleidner extractor. i The p-bromine-aniline is extracted with hydrochloric acid, diazotated and converted by addition of"iodine to the corresponding brocuine - iodine - ;benzene. -"
Page 86: wrm95d00
50335 2585 i3 VL).I:.,e (1971) (in TtlBSCCO--C;a::Mll;ti. CO~t?o5 iilr'„iI TCishCCG--BLEt:'F?IIvGS !TUBACCQ--T'.STE-',E!~,M'.'-`?{: /TASTE--TESTI,N'G--T+?.fi:1i:C:)Or I:JR CLASS ti:l. Pkx1°HLr t 73 V3II Ge Gaorgi cv, S. s~=~~r i nnv S_; Yazad j i.yan, F.. ; Tsonev *(no afffl.)* ! MTHEMATICAL MC): FL OF CIGARF.TrE BLENDS. Nauch. Tr. , Vissh. Inst. Ka:ranit. 'IkusovaI Prom., Plovdiv 18 (Pt. 1) 33-45 Bulgarian with Complete English Translation) i 1 ~ °", *1971, No. 14, W 5745* *lm* Tobacco man+ufaCturC; i I .. ~-..-T--.. ..._._.....~ . _. 0 S Qa n 0 2 4a 74
Page 87: wrm95d00
, 50335 2593 HJ) 49 r l4?7d , A D.4Pr'Abl UTy/ A$ vER1'igtM~~'~e+~t~r~N i eAVOr•.J, 1yl~N:~GFM~~T f TEGHn~c~af~~I L'ornpuTEASI , ditor) r Future Shockby ~.~ `. ~ ,~ ~ 0 5 0 tl o 2 48 8 2
Page 88: wrm95d00
COOKBt1ORS--ASIA/COOK%iX)RS-JAPA.'q/, SOYEEAV. 7~ thm 1975 VOLUME I - V1lILLIAM SHURTLEFF & AKIKO AOYAGI Illustrated by Akiko Aoyagi 0 0 0--0_2__4 8 8 5
Page 89: wrm95d00
Zast. 8i1ja 30 (147) 23-30 41979 VIT CoA2 - 81 s.p. a r. cULTS OF THE CONTROL OF STOQEE~t3 TOBACGO INSECT PESTS WITH PHOSPHINE (DETIA GAS EX-B) W r 4j. Vasi:ev, Ena. B. 7ovanoNd of tobacco, Prilep Summary In the course of 1976 and 1977, we have been investigatcd the efficiency of plxrsPhine /PH,) formulated as Detia Gas EX-B in c~are3 with the other fur- mulations as Phostoxin tabktts and Plate. In each rariants arc appoi~nt~ccl by two biootest, by the 15 larvae of Ephestia elutella (Hbn) and Losioder»ma ser- ricorne (F). In the course of_ our investigations we have taken various measarmentr of PH, concentration in trrated stum bv m~.-ans of AUER-f',AS Tcster and AUL•R- -TOXIMETER, thc results obtaincxl arc :lwwn on Grat+h 1. In all tested formulatims of Pli, irre found; high insectidity (10O9f).I son after onenaiag Cvsnpar=t~tvely; with the test of efficiency of Phosphine in the control of store lxsts on tobacco, cheraical tests were made to prow the effect of PH, to the ctianges of the biochemical composition of treated tobacco raw materials (final products). The use of Phosphine shows cottsiderable decrease of a dry condensate, tarr, positive pr9Pe;;jy in the upto date processing tcchnuivW of tobacco ~ ~ OD f1w t [~ lds.l/bb f ~P' i P ~~ j b il P 2 2 i i t a co t nxn var ous to r acco var es as: -1 - /1, et ep Yaka No. 7, D3a:bei No. I and Otl.ia 09-18/2, shown very good turlcranLe to P1wsphinc, ,.. ~.
Page 90: wrm95d00
72. Vt A'e-79 $.P. RJR CLASS NO. J .„ . . `. ~.~:~ . _ . . ...,'..... ~ ~ ~ . .(Tobacco Res. Bd . ,: Salisbury, R'hod: ) ` A. DJSTILLATTOP METWD FOR THE DETERMINATI4N Olt INORGANIC ROMIDE Ip -° CtTRED T0MCC0. *Reywords:* broinide. •inor¢anic:''cured_ constituent._ Beitr. Tabakforscb., confidentiai"mauuscript,•' 5 p." (1979) (in English) ~ The distil-fation met-h-oc] is very. suitable f ok the resence inor ic bromide in the o o i of a ti ito p g ng r u ne m n n r of chloride in cured tobacco. The advantages of.this method are that it is fast and reliable, and the icapital outlay is negligible compared with that for 4 neutron activation and X-ray fluorescence. Up to ;50 samples per day can be done in duplicate by one rator using a battery of si x Markham stills. I
Page 91: wrm95d00
4kwVMCVo1. 14 Guide to voxld scien,e. 19ir8- [Guaraseyj Francis Hodgson Itd. 2 4 8 -9 0
Page 92: wrm95d00
0 _,..._.o..lv a.im arm - 5033S 2597 ror_r ir oil, t*'~ , .V! E? UFN~rt1715)S-7 4i - .4.r...- 11rus1V11'1JAJ1N.-"VI'*liV1. 8 0 5 Q 0 0 02 4 8 8 b m~aryAkAoAmyaO 0 0
Page 93: wrm95d00
%o7= IIy-%I . S.P. 6697 M6374 P 307 Behavior Analysis an TODO JC NEUROSCI 6IOBEMAV R' Experimental Pharmacology s.309 11Y 199 Departamento de Psicologia, Universidade de Brasilia, Brasflia D.F. 70910, Brazil TODOROV, J. C. Behavior analysis and experimental pharmacology. NEUROSCI. BIOBEHAV. REV. 5(3) 307-311, main 1961.-Tbis paper provides an introduction to the field of behavioral pharmacology. A brief description of the characteristics of behavior analysis is foDowed by a review of the contributions of experimental pharmacology to behavior analysis and vice versa. Finally, a section on new procedures in behavioral pharmacolop+ outlines experimental situations t w hic: hppmp~kiq~ of j~ltav~ ca~jte sl~tsed~nC~tetnpord discrimination: (b) preference to be free and formcdrXc) ~ett~kho~i an~elf.l6ntm . and'{d} r concept formation.
Page 94: wrm95d00
50335 2604 . of nitrogen. 867 T; ec3ee.~kateais, 1955. B 0 5 0 0 n 02 4 8 93
Page 95: wrm95d00
50335 2608 TOBACCO --SMOKE--FILTRATION/TOBACCO"-S.MOKE--VAPOR PRASE/ CIGARETTES--PAPER--PERFORtATION/CIGARETTES--PAPER--AIR PERMEABILI'i'Y/ CIGARETTES--FILTERS--TAR REDUCTIONJ RJR TRANSLATION EFFECT OF TIiE DEGREE OF PERFORATION OF CIGARETTE PAPER AND TIPPING PAPER RJR CLASS NO. TRANSLATION Maeda, K.; Kondo, F.;Noguchi, K. *(xio•'affil,)* ON THE PERFORMANCE OF FILTER CIGARETTES. IV, REDUCTION OF THE MAIN VAPOR COMPONENTS IN CIGARETTE S?iISKE, :' ~~ ~ . ' . k/l~ippon Seinbai"K"o-sTria' 120, 51-60 (1978) (in Japanese - complete English ' available.) *Keywords:* acetaldehyde, smoke, constituent;- isoprene, smoke, constituent; acetone, smoke, constituent: ~y I 'A study was made of the reducing effect of porous cigarette paper and porous tips on the principal gas phase components acetaldehyde, iso- i prene and acetone , S
Page 96: wrm95d00
TS 2240 U ,ln `ra'rl'. C1;RQT._ .'.:e . i> iti 1 3-h :..• i_ v 1.~ : L;: t'..! iY J F' > L. 1 ~ ..~ ~.... •e a .. .. . r r .+. l vt~.{ ~?:_ J.r~_: :J~~; rr SVa: ~ 4: , . .. . .. z . _ ::. .. laKa-r3lcayp ~, ... .-.. .. /~+~W 1JfA'._..._...... V...w...... _ v1.~'..~'. L'~.. ~.... ~ v CA)i (p - ~~ tl 0 0 0 2 4 8 9 6
Page 97: wrm95d00
Iac Mc7-79 s.r. aU lounml of _ -- -- ------ _ - -. ~ _ __._ LONG-TERM TOXICITY OF "lriALTI", - A SWEET • MATERIAL CONSISTING OF XULTITOL WITH SPECIAL REFERENCE TO TUMORIGENIC ACTIVITY IN RATS. Reoei„ed Se,tera>kr a Im for one and a half years (78 weeks), in order to study long-term toxicity with rats were maintained on diets containing in concentrations of 3,05 and 10,°5 in a concentration of more than 75 per cent. Groups of male and female Wistar Summary....... R'falti" is a commercial sweet material which contains maltitol Koraro SHstPO,~- __~i, Yuko Yoxot, Sanae FumvaA, Haruloo KATa[aA, Kame Hnuw.- ard Tsune~vshi TANUSE*++ were obscrved among the test rats. Growth snd food consumption data revealed special reference to carcinogenicity. During the eiperiment, no unusual signs ()no @ffi@te gno*alfjes. "uiogenic acric.7 was also negative. K.y ao.ds : Maltitol, long-term toxicity, carcir_ogenicity. data slzo.eed no significant differences except for a lowering of serum cholesterol level in all Malti groups. Pathologic and paho-histologic examinations revealed no Alalti-related differences. Hematologic parfsneters and clinical blood chemistry I
Page 98: wrm95d00
Report of loaosphcre and Space Research in fapan, Voi. 30, Nos. 1/2, pp. 47-50 (1970 III Dua 78 S.P. / I AN OBSERVATIONAL EVIDENCE FOR THE SEASONAL VARIATION OF OZONE CONCENTRATION IN . THE UPPER STRATOSPHERE AND THE MESOSPHERE TAIUSffi WATANABB Deyrutmc»t of PhYsks, Tokyo Ualvenity of Education. Tokyo 112 Geophysics Researcy Laba.atory, Univessfty of Tokyo. Tokyo 113 0 ,i 4 500' 0 0 2 4 89 1
Page 99: wrm95d00
50335 2610 T7il(\l_i , L. Sf~L.'y^:i:_~i71 by 1. A. . aii.A vO*rtY. {I;:~ ~} ~ 0 5 p 4 n 0 2 4 8 9 9
Page 100: wrm95d00
50335 2592 a.+~..1384=99 - :JJj~ LyYi!!~ .`rm ~. y ~ (// f flabli hi Y~'~~ Influence ouorocron emusons onepatc s P metabolism in perfused rat liver MICHAEL X. GOODNWN, ROBERTO PARRiLLa, AND G t+- - ~ JNfin /?tsosaA Labo.atw2. lhparhneat of iirdiciat, Hmaard Medical School, Arta Batt~ri3Gcat Hotpita4 and tkt J.v1ra 1)in6dts F.rdotioa, Ia., Beston, Afasmr/mxttt 02215; and 11if Do77Dnarl of c3ftdiuAt, Mall.skr Lr,wrrsiey, Haau/e.a, Onfario, Comrde 1 GoooyAnc, MIetrwst. K, Ro.laro PwRaata, Axo C. J. Toe»s. hylswn of flwr.cmbae eaudti«a w kpotie mrta8orirn i+r }rr/axd me Jicrr. Atn. J. Physiot. 22i(ti): /38i-i388. [9i3.-Erythrocyte-Gte Krehs-RRiner-bicarbonate (6RB) butier, erythrvcvte-KRB bufter, and fluorocarbon (FC--t7)-1:RB buffer emulsion were compared with respcet to their ahilite to nnintain a viable perfused rat liver preparation. At 8ow rates of 30 nti Jmin, alanine glue,oneogeneas, Or eousumption, lzctate and letone body production, and hepatie ATP concentrations were the same N+ith all three buffer prepara- dons. 'Ilrc eyuasoGe and mitoehondrial redox states as indicated by the hepatie Ixtate:p}-ru.-ata and ,gh}droxybutyrate:aeeto- acsiate ratios, respceti.-ely, were also.ttu same with the thrcF difereut buffers. However, at flow rates of 20 ml/min or lan. the eonserved. 1"he advantage of an erythrocyte-suppletrnntcd mediutn is that much slower flow ratcs can be used (1 tnl: min per g liver) to achieve adequate o.n-genation, facili- tating the use of a nonrecirculating system for certain studies. However, a problem with the erythrocyte mcdiunt, especially if recently acquired red cells (rat, bovine, or human) are used, is that they consume ¢iucose and produce laetate, making additional corrcetion factors necessary. Ihis problem can bc part;ally avoided by using aged red blood cells (5). Theoretically, fluorocarbons should have the ad%anta~rs nf s.+.a Mtl-..-3...J .....J~...... ~..L~..-. - _'e_. ..
Page 101: wrm95d00
TOBACCA--STFROLS/ ~_,`j . ..,. w . 78 1i'I To RJR CLASS NO. PA*SPNLET 78 VI To " Davis,rD. L.; Legg, P. D. (PNP XXVII, Jember, Indonesia; Univ. Ky., Lexington, Ky., U. S. Dep. Agr., Agr. Res. Serv.) INHERITAJNCE OF PHYTOSTEROL CONTENT IN TOBACCO. Crop Sci. 17 (No. 5) 700-03 (1977) (in English) *Keywords:* phytosterols, green, constituent; cholesterol, green, constituent: campesterol, green, constituent; stigmasterol, green, constituent; sitosterol, green, constituent. pattern of ricro) cat,rrntration and r<eitnata ot ~ eoabitnnR ahi2itr cffrctt .+cre FtutSicd in rccrn eclccttd ~ tobacco wieati«na icrbar:,m 1,.j genotyl++y. 'Pata fi.r tn'ai ~ dcrob a»d iadirir.ual atcroIs in air-ciurtt Iaminac wcrc obtained fro:n the p.-ircntal Lcnotppcz and all 1~e>+•.~k I ! t•ra.acs ar.toau~ the gcnotyptx. ' i Total Rtcro enntrnts of tAe acaotyrs r:en,ed frc.m 1.46 _ ~ to i.St n.;lZ dry K'ctfiht. Stia.n:~rtcrol had t?.c hiaLc:+t ' conc.~ttiratioA of the fnur Ftcrais in fout of ictcn iine1, ; whik in the othcs thrrc Iines, sitos:crol Ma% Prcctn;aina++t4
Page 102: wrm95d00
50335 2603 Increase in the Intraccllular Proteinase'Activity during 71 II Re-72 S,P , •• the Stc.r3ge of Pressed Bakr's Yeast • d:L'[acay oshi Takakuwa U. Fcrmcnt. Tvd~..aj,, Yot. Sa, lW. G, • 39r.~ ;o s„ty~ a •_ 7°{ 9;2d_tE~ry. F?c il:y of AI;(cuitura, Ehimc L'nw6,t , ILIac , su~a,~y y «ihen pressed b.lker's yeast is "stored at 30°C, it usually liquefted ~ u=.thc 10th day and amino nitroat;cn-peptidcs and amino acids-e_rtracted ' from the cells with water inerc~ses rem•trlc.•tbly near liqiiefaction. There- ' - fore, the relation hetween the increase in arniao aitrogen and the intra- eeIlular pruteinzse zctivity was studied in this paper. Of three kinds of -. yeast intracellular proteinases, which have been desibnated as A, B, and C, only proteiraM C activity increased in parallel with the increase of the _ extracted amino nitrogen. This result suggests that protein;tse C is the _ one principally responsible for the increasc of ar.iino nitrogen near liqueflction. 1lie rrc vivo mechanism of the incsrase of Proteinase C = activitS ..mijh.t be more complicated than tlie in vitro activation, because the activation of proteinase C such as was observed in the preparation from fresh yeasts, we,zkencd~gr~dual,ly during the storage of yeasts and .Q• •_dW.ii~ic~l a~cr ffiic i~idA s~loc~f ~Se storage.
Page 103: wrm95d00
sOBAafCs'b FFUS{~N~OFFaG7~3S~ES Qj ~74l~'ACI'CED 50335 2589 .~ , _ _ 7Y .EDS OF FINE PARTICLES~ ~~ '" t ^ / MAsmtttt ASAEDA, Mottto NAKANO AN Deparlnrent of Chemical Engureering, Kyoto Unirersity, Kyoto t}iffisioa of Kaws through packed beds of particles under uniform total prcwture k studied a1Stieatly by esing the rigorous kinetic theory of gases with the two-sidrti! Maxwe/tian velocity strlbotaK+ Wnctions and iVtaxwcll's transport equation. Attention is paid to the solid parts of e packed bed_ds, although most investigators have concentrated on the space structures to obtain a we aodel. With some abbreviations the present recutts are quite similar to those of /•:ra+u eL, which were dcrived from the macroscopic mutticompnnent ditiu.~iim equation by considering ie prtietcs as giant moleeules, tiut in the Knndscn diQasi+m region their results arc about .4 Ii.cs lartcer than the nuthors' or the experinrental resnUs. The present treatment is con- derd to he more adequate and general than that of Evaas er al. and others. To abtain ex- eri.estal confirmation of the ana{ytcal results a simple method for measuremcnt of the effective idfssi.itics a.d flow pcrmtabi(ities of gases through porous media is proposed by ush+g the wett- rmw relatiew. -KA1NA=(MnI)WaP"'1 which is also derived from the present treatment. The oocs zperi.+entst tesults by this method are in relatively good agreement with the analytical ibtaiwel here- This is peritaps the first dircct exftrimental confirmation of the dependency of the ae.s effectie diffiai.ities of gpsts through porous media on composition. ~ 5 0 O 00 ,~ 4~,i., ~s .t:rr...:.,., ,..,+P t.n thr ~luctv eas model thw ~.w~..i.~. ~qw
Page 104: wrm95d00
.,s..r..~ X To7 50335 2615 `.owl' T ,. ~1 t~t, plA...},,. V 1 .it i\~1 ~.l:~ti ): J ;iwnldo ic. 7S~ 'YS3o .. a,,,.. o~o.ono.2 4 9
Page 105: wrm95d00
80 II Ho ~ ~41 =Rtlated Pehavior Zmnact of the ~zse Mil• Islaad uciear Inc:deat RWrt Subaitted to the T!II Advisorp Paas1 1 50335 2614 Oa ~lth Research Studies of ?!K P~attsylvania Departmsnt of Health ~ -~......---- ~j ;*Peter S. Houts, Ph.D., Principle :--vestigator PART I9 'ftbert u. :Siller, Ph.D. ~~ II Dr. P.fl., P`:-_ - +t*!Ws Shik 9as3, Ph. D . : .%,, cne *The Peaiuyivaaia State Uaive:sity, College of % and **The Peacsylvania Departmeat of Healta april 8, 1980 o~so'oo)a + )
Page 106: wrm95d00
Bimaedicine 19 (No.5; 202-4 (1973) ::~.p~3 73 A DOUBLE BLIND STUDY • F: • ON THE EFFECTS OF MONOSODIUM GLUTAMATE IN MAN ` by G. ZANDA, P. FRAI\'CIOSI,~~; '~i. RIZZO, S. yI. ST3UNDE.N, P..L. 1IORSELLI and S. GARATTLNt (Istitrsto di Ricerdw Farmacologic7u e Yiario Negri ., Mi1an) • . SUM3tARY 1Konosodium glu:amate was administered at lunch time to 73 healthy subjects using a double :..: .. blind design with each subject acting as his own ccmtrol. Care was taken to balance the sexes, and to taotu any psychological effect of grouping. Both subjective and objectire measurements were made, and at the dose eraployed (3 g/subject) no diff;rences in symptomatoiogy were found -betwrett the control axid.LiSG treated groups. " ~ R'gSUME ~ - . . - . . . . . -- - r - . . i .r. . . Du glulamate monosodique fut adsr:inistrl au dluunrr d 73 sujets bisn portants se!on un 4sroloenle eT+ dn»h!• n-r7t• c^aqtre _-' flc-:! ,,.,. Des prieautions furrnt prists )7otcr lquilibrer la rlpartition selon le sexe, et pour f0iier tout e.lfet psyclrologio,ue de graupz. Des ...i .~' •. rnesnses a la fois ju5jectircs et objectives furent appliq:czes, et, a la dose eruployEr. (3 g/su,+et), '-: auettu diffher.c ece ne /ut lrouvlc entre !ts groupes te'moin e: lraitl au glutamate monosodique. ; NTRODUGTIO ti !n our previous esPersnent. subject:; irere 9rouped in a single room for the whole obser~•arion n?^'~~d Diozcsoc)i~t:n n1,.t:,r. a«F 1'+ , µ _ SSC•:i ~a:~_hrAn. ho ~ ~ • . . ...------. . -. _ .> •.-___ .- -.---•. 0 5 0 0 0 0 z48 8 g
Page 107: wrm95d00
~ " 50335 2509 °- ? 2 III ; , ~ ~ / AIR--POLLtITIDN--AIiALYSISI s-=5-.-. . __._ MultiWCvelen91}t l~ePileloC1l@fer Measui~t.m ~'~m in Los Angeles Smog. Aerosol 111. Comparison to Light Extufction by NO2 R. J. CHARLSON ~.n D. S. COVERT ~ Water arul <tir Jteaources Division, Civil F'aginetiring Deyarlrttent, Uniseraity of {i'aaAingtos, 1 ~`~ Scattle, lt'r.ahi~agtoa 88106 i6a.• 13 (1)r i i47A, A\D -W•4f" _ . su F'I:TEIt K. \NELLElt i f ~ i Ass and Induetrial Aygicnc Laboralwy, Lal,uralary Serr•icra, State of Coliforr,ia, Depar;raent uf PuLlic llraltk, I>erlL•eley, California 94700 Received Mar,h "G, 1971; xeceptcd June 1, 1971 0 5'00n 0 ~4~49
Page 108: wrm95d00
~~mr, ~ RY__ ~~.~.: • ;SOI'ROI"YIr1T, -w ~',aaeeat :o. Atr atlons 3.n S'am-mqu:;w T~.Ad ia+ ~s Date3mia"i';ti!:31 of A.1!m1U: 'Iis tT Ya'c3a1.;: c.a t~'it3 R;.rd rochlar9,a A.c id Cea~3e.~ of G~~ar3e a ; ~ ~r~ I~~ cpropcr,t3,de. )~, ~ I. Simarqi and GQ War. FbCtCOtElt ftan! UtS NOe ukad. BCl• 1?=5• f ?~ Wo• 3} 305-1? (ASO) 0 5 0 0 n 0 . 2 48 1 5
Page 109: wrm95d00
50335 2611 ass-ta 76 Ima_8'ASSACHUSETTS INSTITUTE OF TECHNOLOGY r INDUSTRIAL LIAISON PROGRAM i c11Irsr71L ssRmCTVW Of TBL IIOaMasTERN olfrrED S'r1lM: CaerrRxsTs z1WWZ= ?u GRtNVZI,Li AND APPl12dICffi]IA PROVIlICLS SLsna t. Taylor, liieha.l P. Chaplin DsPartswnt of Zarth and Plaa.tary Sciences DISTRIBUTED FOR INTERNAL USE ® MEMBER COMPANIES ONLY. MAY NOT !E REPRODUCED. F s. Taylor, ll. Tokso:. M. Chaplin r }o {) o(s ae 0 d o~,V 0
Page 110: wrm95d00
50335 2616 X To8 • y% ~ S0 FIX`%AN LL',ia CG1'q~=R AP;D ~ ~ iV ~~ An. .rtttta • !'Ut~i iC ~-i112f1 ~ '2!++32 (~ S Q 0 ~ 0 2 4 9 0 5
Page 111: wrm95d00
CER OF THE LUNG: HOST AND ENVIRONMENTAL INTERACTION/ a RC .262 Ly 1976 11 'LUNGS-CANCER--CENETICS/ GENETICS--CALfCER/CANCER--CAITSATION BY GENETIC FA CTORS / CANCER GENETICS Edited by HENRY T. LYNCH, M.D. CHARLES C THOMAS • PUBLISHER Spring/ield • Illinois • U. S. A. ~5~0 0 a249 0 2'
Page 112: wrm95d00
i -- ~~ ~--4_- 'Ai . .. : L 5cand I Work fnviron fiea1th T(1983l 31-1? III !7e -8.1 AENZO(a)PYRENE/ '! ,~. ,. Changes In rat liver mkxosomal cytochrome P-450 and enzymatic a iUes ~fter the Inhalation of n+Kexar~e, ~ne,afnethyl ethyl ketone and methylphtOrotorm ~ for four weeks by~ ~• = Odd G N#lsen, P'ttQ.*• 3 Jan-Ake Gustafsson MD, PhC TorrcABD a, liII.SII+T oG, tiUSTArjSm i-A• Qsan;+es in rat liver micra.omai cyto dircase P-M and enLTmatic .etivttfes after the tnlsalatioa of n-hexane, xylene, methy eftl kakne and n~Sifyi~lweads~rm fot ftur vreeks Soatd j work enutroa health ?(1»l I1--37. Groups of Sprague-Da.riq rats were exposed, by Inhalation, to n-hexane ° (M Ppen; 3,riB' mihA. z7lene (M Wan, t,lMi mgJms}h met>r,yl eih11 ketone (S00 DPm _JO a9a/n1s) and IDe-1 1C-1f1h 0E'i (M PPMs f.M 7OOIDS) fOC SOllt WelkS. lIIQYafet • • liwr wetpta and liver to body wdght ratlor were observed for all the solvents except a-b~. An incteased In vitro faalatioo of Gettain me3abotTtes of all the Investigated substrates was lbund oaly in tLe raks exposed tio zylene. The !n vitro microsoma3 metaboll.m d 1, ipyrene. 4-andrusteme-a,l?-dioae and sa-.ndmstane- a O~,~17}di in nr~E~ iodium dadecyl saltate-polyacrylamide gel electro- ~!t e!a! ! .ras wf>~t e![eet c® rat lfvas microsoinal cytochrome P-4S0 and that methyl ethyl ketoae and mal$ylchioratozm depressed the formation of tevo r+ela?~^'=`~s of -^3rostenedi:- - d~*' ,~!
Page 113: wrm95d00
annet telemetry system fuF monitoring e;cigA cardiac Qutput, rate of respiration and basal transthoracic admittance / A. R. S. s"twwi K. rsmskosM .;. ToVOshirna T~k~d *SFAL CtT~Yq~y yo„101 . . ~ t. ~. ko O~tw.~~ a1 tMrab~l. Rt~ 1Jui~r~ilY lehad et M~diei~. Mfi~M.-M:. T.k1~a JrM1N i#amt yoAWW W%th b"GO . -owe n is JUss GAt+• .12 O~f. J~irl~lr~r tt.nonrtM Jw i~rprr of o0aet f61Dw~, it wti~A~ `~'~~, ~~~ a Of 2Vlf• l7~~lM ~~ ,~/l ~~IMW~1l~ F~Qftf~xMAMO! T/1f ~~ll /Md S ~ Y `~/~w~w/ w/IIMf~fJ~ IIH , .0~VA&MAMmwlmwomkv dt.Ayes P~s.Orxat+o+r aw+du4tiaw/nit baw wdiri i/Yr t~Iwsl~ent Th. m.~n~kn.~nir dth. #M aanaAor.ac nntitnnce and 1ar +ari.NOrU aoniqqpondYp ts Mir a.d'isc eyc/e and nspira[ory A~w.n ~Ey~er ir d~sd ~i~rrpt~A~r adw+ttano. pNrA~r~w.~r.pAq brs born.mp/oysd to obtsin CiRdw IfMRil4 Iltt ol flSPA/JliOA, f_C.O. and blN/ hw"NOMM 1dWANW10f of tAe wICOnIf!/iiEfJMd Abst/Wt-~1 d*M-dWtrW lnqwncr-modUdrtiOn MAws"y sINww IfOr ANe owninvosiw tntasuronrnl oI
Page 114: wrm95d00
I O. Furukawa, Yasuko ANTALYTICAL METHODS FOR CHF.MICAL COMPONENTS OF TOBACCO SMOKE. III. ABSORPTION SPECTRA AND SPECTROPHOTOMETRIC DETERMI'VATION OF TOBACCO SMOKE TAR, by Yasuko Furukawa and Chie Tokura. Trans1tion from: Sci. Papers, Central Res. Inst. Japan Monopoly Corp. 1969 (No. 107) 315-17 !196S1 , ~ -- - --~-~-~T {~ S tt A~ Q, 2 4 9_.0 6 I;
Page 115: wrm95d00
, 50335 2620 II _ ~ Xh2 ~ - • --, ~ Khaa, ~Op P~'~OLE AE*cTSfi~.4h CiLJLii+^°._'Y.1CH OP C__ ~ Yi:d ri• A T~/.Y3.1.~• By C"_'Cor_sL b, A* ?.27 4) 217-21 (1966) gotras. G.gs. ~
Page 116: wrm95d00
r,._ r... - r....-.~. .AC00-,ENzkqGS-/ ZnRJ~rn__NTTRATES/ 73 V1 Da2 RJR CLASS NO. PAAiPHLET 73 VI Da2 Dalling, M. J.;~___Pe,~m 4! ; Hageman, R. H. (Michigan State Univ., Dep. Biochem., East Lansing, aich.; Univ. I11., p. Agron., Urbana, Ill., U. S.) INTRACELLLR.aR LOCATION OF NITRATE REDUCTASE AND NITRITE REDUCTASE. Biochim. Biophys. Acta 283 (No. 3) 505-12 (1972) (in English) . *Keywords:* nitrate reductase, green, constituent; nitrite reductase,'green, constituent. *1973, No. 7, W 2807 * *l.as* Tobacco agriculture: 0 S Q 0 C1 42 4 9 1 1
Page 117: wrm95d00
(595T) 9TVif-fi07T ' £ Uc;47zspe,d T*x3ao:) VoT3nncsa za3tM •anor traxatL •2 •Q 1DU2 _USVM x3$a: nZ •r •di Aq 's3ssROa3 Str-~-n,~XvMT, ja,ttip MOXsMMOa xs saTSuuzas H-DiR Aa s0MIMo1 •r •g ~Xo,aspn°i 9961 ~»"Wmft&iitAitN09 dali
Page 118: wrm95d00
50335 2618 TRi,ivSLATION MCOmzq Am TAR IN CIGAAFM SHUKS. Ii. TRAPFI2"G WAC3ET!' OF CAMBRIW? FILTE3 FM VICOTZPiE AND TAR, by Tokura, Chie and 4ssuka Furakataa. Nippon Senbai Kvsh.a Csuo Kankyuaho senkyu 8akolw Iro4 00.105) 289-93 (1964) • Lrjgliah trauaLatirr~a from ttze Japuntse C: ~a"sp-e.r~ 1 ' 0 5 0 0 0 02 4 9 0 7
Page 119: wrm95d00
PITAMIN C/ 50335 2619 QP ~ ~(Project Director) 772 Supported by ,, S. Army Medical 8essarch & Development Command To AgC©$gIC ACID, BI©IAGICAL FUNCTIEIN AND CHEaSTRY, ANNUAL 1978 PROGRESS REPORT August 1978(for the period May 1, 1975 to June 3, 1976) Contract No. DA-49-193-MD--2611 I1DrA061Sf06 Department of Chesistryi iversftT of Colorado, Boulder, Colorado .r ' 8~'J' 000 0 2 4 9Q8
Page 120: wrm95d00
. 50335 2628 6th International Congress of Essential Oils, San Francisco, 1974 ' 1NVr..'STiGATION ON THE ES~LNTIAL OIL OF Ar?TEM15'LA ANNUA L. lliya V.Ognyar.uv, a:lenst r+t.••arova, ..ve;enii ti Georgiev Higher ins ti tute of kood l.ndus try, )lovdiv Depar tmeut of 'l'eclinology of the vege tative and essential oils Annual wormwood /Artemi5ia annua i../ is a. ti+ide-syre.,ct raw material for industrial lrrbduction of e5sei,tial oil. Due 11 4
Page 121: wrm95d00
50335 2627 ...~.... ~.. . . ~Y TOS.ERAWXbS-<.tfR ~ AftSMIC AW Frost, Douglim V. TOY.MNCES T4R ARSLiVIC A.ti'D SF.L'FNItT,d: A PSYCi6QUYNAMIC PRtZ,ILZci worlc! Review of Pest Control g (No. 1) 6-28 (1970) 4 SOo no.2 4 9-_,1 6
Page 122: wrm95d00
yZ 0 0.0 0 S r:to;xo ecaxd nam8zad *e8ld g9T L9£T (Atv4A ' I d9 vaas'tacVs1) Ase3l2Ioy • r uug 'uRN=g •Z Aq `SKOZ.LY3I,LI3 :I<3Smm0m8 • ,1 • umag
Page 123: wrm95d00
50335 262+1 II S I P. Du?-80 Etadc erPeriuuntatc ches Za Souris do L toleranee du poumon au,~e L} tit~ocarbures eblorofluores t*), ~'~ Mu+'t++aeeutf~rsi f~~e Noma t PCW b. 1M. W* 11, t'i'- 727.239 A. QUEYAZIVtLLER. M. C2i1iIGNEAU et 1!!'' M. SCHFMME.. Dana un mctttoire lwblig par deuc d'cntre tious arec Ia colluboration de Vo Neac IIun. [7j, la tolirance locale (peau, tnrrqucuses, plaies, brulures) chez t'animal, aux hydrocarbures chloro8uores (C. F. C.) a rt6 Etudi& Ccs produits { plus connus sam Ieurs noms cMYroses (t) sottt maintenutt tris utitises cotnma pul- seurs do produits meitasets, cosmEtiqucs ou piarmaceutiqucs dans des appaieils appelEGs do faCon doublement improprc a bombs acrosol s. Lcur pcu do reactivite , chimique et leur ininQammabilitr garantissent IenF sicurite d'rtnploi, mais lrur toMrancc par la rean, les muqueuses, Ics rlaie.s et lcs brtitures n'avait pas fait Fobjet d'une etude expe'ritnentale, x 1'exrept'wtt do quelquca-uns d'entre eux. Egnwv1s sur la pesu du jeune liat par 1'un do nous et ses collaboratriccs S. Gaa- ctr et J. CaxF:r-I'ornett (G), leK recljercltes nat ctE etfec'tu6rs sur lcs pulseurs suivants : 4 w . - ,.. O,5 010 .0 '0 2 4 9 1 1 3 . J I ,
Page 124: wrm95d00
- 50335 2612 I~..s.~.-.y~.~_._.-_....__~--...~.-----~-~-.__...__ i ~t• ~ °`'~'Tiit~~"0~.~...~.~. •~`ry~; Ma ~ r @~cs, Kaa3 i r 4JW 1"Oy-SyCZNOSC Krs ~7 1ITOIIO&JEGp ~ILTSZy(~ S~LADNIKO~T (Tsaic Propertie,~ of nicotiae ~y~oi~ ~ootrae, Other of tobecco ~ tcbacIId related coo~pouada CO +~oke) Polsk. Tygod. Le (1965) ~ ~'• 20 No. 21) 775-77 P-r,s~ •-:~-:~~~-, 0 5 0 0 tl Q 2 4 90 { M 7-
Page 125: wrm95d00
5033S 2632 0s0o0 TELEPHONE LISTINGS/ ~~~........- _..,._ ~ ... _` r.r ,M.-ml ...c ,-taSW66~' _ ~....~.--- ._...~..,.r•~,jm~, ' MMMr.W i..---A- . _ ., _ J OW EU TOLL-FREE telephone listings. ' L: ~ P~bUsh(ad annumFui-El yy YonQ®FrC:e DAgest C®.9 Onc. DIAL ~ OLL-FREE 7y,y.. A directory of over 14,700 ~ A I ~ m WARNER BOOKS 2 4 9 2 1-
Page 126: wrm95d00
RHF Q 141 To 1978 TELEPHONE LISTINGS/ 50335 2633 r DiAL ~ TQLl.-FAEE . A directory of over 14,700 . TOLL-FREE telephone I, ~st;tnqs. PubUshed annually by 0 Wu2NER BOOKS 249 2a- A Warner Communications Company
Page 127: wrm95d00
BIOCHEMISTRY, YOL.1, OTA14ICAL CHEMISTRY, V.1,2,3/PLANTS--CHEMISTRY,V.1,2,3 PLANT CELLS AND TISSUES v.Z/ PL.ANTS--f~TAB~ISM, v.2/PLAtITS=-RfSPIRATI(~i .,v.2/ TISSUES--CULTU~,.y.2/ ~J~tCN--CHEMISTRY, Y.3/STARCN--BIOS1/1+[MSIS,Y.3/ STARCH--DEGRADATIOtl,Y.3/CELLULOSE--BIOSYNTHESIS, v.31GLYC{?MEIIiS,Y.3; ' Po1.YSACCHARIDES--BIOSYNTHESIS,Y. 3/GLYCOLIPIIf5,Y.3/PL1NI'S--CEl.i. WAl.LS,Y:3/ , ASCORBIC AC%w Y:3/IND.SITOL,Y.3/StKRf>U, SlOSYMTHES'IS & METABOLISM, V.3/ QK ~THE BI~CHE1VfQSTRY R=~-~=~.~- * ~- ~ sf ~~ • „Ny,~"eY.`~4' . ~ . 1980, ~f ~.~,.,f~ ~ mom c.ML,r, I ~ A coMMEIMxMv8 -rxbA ,lbb voL . I,. THE P1J1MT CELL, by(ld. ) YOL. 2. METABOLISM AND RESPIRATION, by D. D. Davies (ed.) VOL. 3. CARBOHYDRATES: STRUCTURE AND FUNCTION, by J. Preiss ~ACAM(1C PRESS ~ . a+..~7...a......~.A+. l.r.... = 1f.. Tok t..d.. T.n.b ftiy Sr lr..d.r. w ~. w - -~s-qw, : rw~=..~e =ar ~. _ . . _ _. (ed.) . ,,
Page 128: wrm95d00
8 F i}5a~ .~.~.. i ,J tra~0 l~~9 :. f P~ ~~ y JJJ~ 05O0n O-2 4 92 S
Page 129: wrm95d00
TOBACCO--SMOKING--PSYCHOLOGY/SMOKING HABITS--GERMANY/GERMANY--CIGARETTES/ TS RJR CLASS NO. TEXTBOOK TS 2240 To 1974 2240 To p-' , 1974 *(rio aff;l.)* CIGARETTE SMOKING - A CO~,'TRI3UTI0:`I TO THE PSYCHOLOGY AND PSYCIIOP.'1T:lOLOCY OF THE S`iOKER. *(Zigarettenrauchen. Zur Psychologie und Psychopathologie des Rauchers. Springer-Verlag, New York, N. Y., 126 p. (1974) (in German) z,ummary: A German language monograph by a psychiatrist at the University of Munster in Germany. It is based on his study of the smoking habits of 800 subjects composed of blue-collar workers, government employees, and university students, plus an additional population of 200 alcoholics. Decidedly anti cigarette smokinq is the tone of the study. Many parameters are investiaated such as smokinq among children, juveniles, and senior citizens; attitudes towards smoking; physiological and psychological causes and effects of smoking; relationship of smoking to alcohol intake, drug consumption; smoking dishabitation and abstinence, etc. No control populations were used. 1~ V.~J 1 Vt JV.~ 11 ~V • JV. 111 , Three overlappi~,g reasons ~^r r"•nL1^g aNQ cl:;^~^a. °°.^~;^~ ~cr enjoyment, neurotic smokir,g, and addictive srr.okina. Includes a comparative evaluation of the literature. o~ o o a Q 2 4.9 23 ~
Page 130: wrm95d00
50335 2642 2 %tA FTM, L ~~~IOH t~Y" R1~tC~ Drugs of Tc"q 2(I3o. 1) 20-26 (1966) C ~J 5 0 0 0 0 2 4 9 3 1
Page 131: wrm95d00
50 335 2639 ., U. OfJ'ice of Education„ Earned degrees conferred by higher educational institu- tions. 194-7/-48- 1' = = /" ` 7 Washington, Federal Security Agency, Office of Education. I v. 27 cm. (Ita Circular no. 247.262 1. Dcgreea, Acadcmtc-U. S. 2. rIi3gher educatton, r. Title. ( 8erles ) T.111.A72 no. 21710" 378.2 E 49-19* U. S. t)lflee of Eduent fdIn. .1 LtLrary for ldbrary of Cuugress jf;Ui 11 t A 5 t1 0 n 0 2 4 9 2 7
Page 132: wrm95d00
50335 2639 Tasrsky, Leroy W. La TOXICOLOGY OF OXIDES Og NITILOGEN. I. TOXIC CONCENTRATIONS, by Leroy W. La Taarsky, E. L. HscQuiddy and J. Perry Ta1Lmaa .Tcur. Ind. Uyg. Toxicol. 23 (No. 4) 129-133 (April, 1941)
Page 133: wrm95d00
thing is happening out there, not to everyone, but to a demonstrable f ew. You may be surprised to learn ... 50335 2635 3 WHAT ONE LITTLE AD CAN DO Leo Bogart,~~ and Frank Orenstein What can a single ad or commercial accomplish with the multitudes who really couldn't care less about what the advertiser wants to tell them, and whose attention is diverted by the clamor of in- numerable distractions in daily iifel Advertisin$,men.generally assume that even those messages which leave virtually no discernible mem- ory trace at all may, through the force of repetition, Vm tt a~~~ du~ cif'~ . '~ Th~commod'thed'f~y h'.Ls it'fhat c'onsu9me~'carr~ by advertising, but to what extent are they influ- enced directly by messages which reach them when cofee is a salient subject for them? The job-hunter reads the classified ads with a purpose and with his attention strongly focused. Perhaps at not quite the same level of intensity, the woman who is in the market for a new fall suit will study ads to get ideas on the spe- cifics of style and pricing be- . . • :yTr',;7: Is1• . ~
Page 134: wrm95d00
50335 2640 i rf s..thnrl E. L. :0XZCO'.,QO'Y' OF OXIDES OF NIV-0GEN. ZI. .,.= .~a ~ ~ !T „~_prt~I ,,..,~.r . .S~ t i£.(A.vi+..it~~s...4 A.C.AaJ 2` sJ ~la~S 1`i.'=~ ll%ca+~~, Z. L. NaCQcaiddy, LeSOy W. La J. Perry '4o:lraern, And l.gisLar i. Ptnl.ayacen :::":. i.yg. ra%~.czs.. 23, ~.~~-zvc ;A. ; V Q 5 0 0 0 a 2 4 9 2 9
Page 135: wrm95d00
;v°3GGLCGY OF OXIDES 07 .42TROCEN. ZZI. GRaSS nNJ3 NI!-701.rAGTCAL PATH+s'f..', b? ,T. ?ev-ry Tt+17r,nns ~zr:,y 4; . La 'ieHB[ty, E. L. Ma.c~'.z,-Wdyr .•..nr! Stan2ay Schonberger jc•ur. Zsid. Hyg. Toxicol. 23, 14,1--14? (1941)
Page 136: wrm95d00
TOSACCO---TDRICISH--USES OTHER THAN SMOICING/Ft]NGICIDES/BACTSRIOCIDF.S/ VIZI Me -'79 • S.fi 7. - - ------ -~ :::--.-~.-•--- ~-.---•.. ..~.~.......-~--~---,..-~..--d--_ ~ L .• . . o T~ A[ L@e 11!\ S11fbi]? Ow HTT• v_ _,IQ .- w._ Georgiev`, W. V. (Higher Inst. Food Ind., Dep. Technol. Fatty. Essential 0ils, Plovdir, ON THE POSSIBILITIES FOR PRODUCTIOp OF AROMATIC PRODUCTS FROM TOBACCO I: AFTER THE HARVESTING. •• : ' . . °: Rivista Italiana. Essenae- Profumi.Piante Of ficinali 60 (No. 5) 314=1$ (1 I (in • English) . . • . . . .~.- The eoncrete obtained fronm separatparts aof oiientat tobacco (floscules, leaves and stems) left aftsr Irarvesti l es a' ' eav K-O,~flsi fm was studied. T7re pields or concrete wrreed from 0 17 'K to 0-16Sfi for Whott ptants O30 , 8,37•0,46fi for flosculei The basic p)tysico-chemical indices of the produets wers tstablished The uoma was` te~ am ' p cr~taneous s fCnest in concretes from jloscules - with flotiverly, honey, dense and adhesive character. The epr were negative. The bactericide and jungieide action of the eoncrete against dermal saprophyt and patkogen~Tc microorjanisnus was investr ated. A moderate retcntion of their tro~vth was estabtished. 0, 0 fl Q 2 4 9 1 8 W_
Page 137: wrm95d00
50335 2630 . (2G0~tISTRY, ANALYTIC--_TRACE ELEMENTS--DETERMINATION/ TB/1CE EI,EMErITS--ANALY S I S/-HERCURY / S ELENI UH/ IODINE / ~. xJt MWIRATI0l1 . WCOWOSI'ITOx OF BIO[ACIClIL IrIATERIALS FOR THE MER"RPATION OF E7CTREMELY LOW CCMTS aT TRACE ELEMENTS IJi LIMITED A."10iTNTS WITH NITRIC ACID UNDER PRESSURE IlI A Z8FM TZJBE. .. ' *-,t.",a . . .. ... .... ZeiLschr. lb,.il. Chem. 260 (No. 3) 207-209 (1972) By: Tots, L.; Kaiser, G.; Tschopel, P.; ~ SUY,Nl/1tT . - , ". , -.:. . For the determination of trace elemeats (< 1!"e e/.) is biological materials (e.g. tissue, food, sea age muds) in samples < 800 mg a pressure decocusoyi- tios.itL s%* acid or a mixture of nitric and hydrofluoric acid in a teflon tube is described The recoccries for ds aslat& demeats, e.g. Hg, Se aod I, in the ng-range were investigated by the tracer method and w'rre ~ bs.d to be > 98'/e t
Page 138: wrm95d00
0 . _ ,, . 50335 2625 n ~ r°` ~sur la tolerancc du poumon aa..c hydroe.~arlt~ flnuoaris (*) Ase~a.tis P&WMowuE'?"ss fr+`"~r`tes t; S' P""2 °i' Nonvcltes recherches, chmt ta Sruri,, >Sft~ ?!, a• 1. M =S`a h. QUEVAUYIE.IER. I. $ILLC}N. j. LONGUET 4, 1 Pf£SRE t"). QCA.irs tilygf?ae, Fscaltl d. PAarmecie,.4, areaae de t't>i.eseamiee, F: 7;-t*arir6•, d Seaice dss Rechsrckes des L.boraaires G~m~uct.l . . De nombreuses ree:herches out deja cte effectuiea s.r h toUr,tnce des chla- roAuoranes (CFC, Frivas`, Foraues*, Flugines', etej thu 1'aninial et cbes 1'Sornsae. L'un de nous (A. Q...) a rapPortE en 1965 se quo t'on savait I ce snyel, en particulier sur les chlorotluoranes 11, 12, 11 + tg„ Il +$3 et 114 dont il avait Andic les elfets sur !a peau. les muqueuaes, les ptaies, les brOlures et le parenchyme pulmonRire ea se plaCant dans des conditions asscz s"res d'h!cg'e~ne industrielle [8). 11 en a.ait conclu que bien lofrrFs par la peau intacte et les muqueuses, les cbioro!luoranes retardent In Anse de cicatris,tion des plaies et des brulures [3, 1]. Tous irritent le pareadkwme pulmonaire de la buris k )a dose de 10 900 ppm (I %) pendant .ing!-q.otre heures, 1e CFC 114 paraissant le plus agressif A cet Gprd [3j. Depuis, d'a.tees travaux ont kc eiLc+c- tuds, tant en France- qu'a 1'ktrangrr, en raison Je 1'myortance qu'ont pris les Auoranes comme pulbeurs des substances lcs plus diseues, en droguerie, lor- fumerie, alimontation et hharur.:cie. C'est ainsi qsu Ov P<<uzEr. S. DrsanousSEs N J. Son.sss (2) espoFant des souris et des rats 4xndaat trente jours, huil heures 3' et ppi~ s di mr,tange CFC 111 -F 12 ont observd des . .'[ ,
Page 139: wrm95d00
50335 2647 rZS 122 T I " , , Ionic interpretation of drug action in cheniotherapeutic research. New York, Chemical Pub. Co., 1955. 276 p. illus. 23 cm. Includes bibliography. 1. Pharmaceutical research. i. Tltle, n. Titbi: Chemothera- l,eutic research. G5-4015 j 1ts1-i3i;X6- 015.072 l.ihrary of Congr ~cs 115), T . .-...-......•.~ F .~r,.,,,,-.~, 0 5o 0 n o 2 49 3 6
Page 140: wrm95d00
ADVERTISING AND PROFITABILITY Roger Sherman an* Much current empirical n•ork in industrial or- ganization rests on a paradigm that has two main links: (i) determinants of market structure vari- ables, and (ii) effects of market structure variables on behavior. For example, technolo; cal determi- nants of concentration and entry barriers have been associated in turn with high profitability (2, 161. Advertising does not fit into this paradigm neatly, for it appears as both an aspect of industry behavior and a determinant of market structure as icell [2, 6, 30]. Indeed, exactly how advertising is connected to market structure measures has been a subject of controversy [6, 8, 17, 25, 27]. If advertising is accepted as an independent market structure vari- able it is a very important one, because it has been linked strongly to high profitability (6j. But u-e shall argue that advertising is not a genuine inde- pendent variable; it-depends on technological fac- tors and prices, which determine the variability of total cost with output in the short run. Ohe rt~ lit~f toal Ot N~h ~rt-~n tjat6 was ca~ured nicelv in Lerner-s "measure o~f nno- nopoly pos~ er" j 15 ], which equals price minus mar- given by technology, so it seems more apt to be the determinant of advertising than to be determined by it. But cost variability is not related to adver- tising alone, It also is related to profit when uncer- tainty is present, through an effect it has on the variance of profit. So cost variabilitr can explain both advertising and profit, and its omission from any study of a relation between them could lead to faulty conclusions. Since cost variability can be represented empirically, these implications need not ao untested for lack of data. Here, after we review reasons why cost variability will anect both adver- tising and profitability, we investipite the relation- ships empirically. We find that cost variability rather than advertising is a determinant of profit- rates in consumer goods industries; and in other industries as well. Cost Variability as Determinant of Advertising and Profitability
Page 141: wrm95d00
50335 2648 DETI:Itltf `'ATIO` OI' TIM COMPOSITION OF TIIIti.F.-C4MPOSG`'T ,&LI'1IEltIC S1'STG)(S BY PYftOLl'SIS GAS CIIIRU1fATOGItAPtIY Y. It. rilislaoer, I'. G. I3erezkin•, S. II. Lashova, G. A. Jitrxarittev, G. N. Yetros, E. N. i'ilctorova V- . /`t i~/ ~.~t7r~. d• ~Y. ~f 21 ~ 7 J~ S u m m a r y ~77? - 27pf /' W4 The possiLility of using pyrolysis gas chromatography for determination of the ~ S~ Sw.arrvtty} eomposition of three-cotnponVnt polymeric systems has been demonstrated, as erempli- ~ i ~ Iied Ly bloac coPolymers ana mechanical l,Iends of divinyl, styrene and 2-r•in}-lpyridiae homopolviners. A su;."estion is made t.o use the externai standard method in pt•rol}'sis ; gas chrorw,tograPhy and the advantages of t!,is method are considered. The tucthod can be used for identification oi pul}•mers and determinatiou of thr, composition of mufti- compor,eir, polymcric systems. T!re methods of presentation of experimental results aro r given, which lead to linear calibratin f plots. 4 0 5+D40 0 ~493
Page 142: wrm95d00
,-'OL. S`_l1 GEAPHYSICAL RCSEA[tCil LL•TfE,RS HIGH CORREI:ATIONS BETWEEN VARIATIONS I1i 130'11ILY AVERACES OF III Du2-79 SOLAR ACTIVITY AND TOTAL AT:•IOSPIIEKIC OZONE ~ .. r ~~ S.'P. W. T. Blackshear an NASA Langley Research Center, Hampton, Virginia 23665 Abstract. Estimates of:the ozone total columnar content, derived from t7ibus IV IRIS data, have been analyzed to esti=ate monthly averages of the total global atmospheric ozone. Over a 9-month interval, the variation in this monthly average is approximately an order of.magnitude greater than its associated uncertainty, and has characteristics in co:mwn with variations in the 10.7 cm solar.flux, the Zurich sunspot nucber,and the total solar Lyman a flux. The highest corre- lation, 0.94, exists between the variation in the total Lyman a flux agd the variation in the esti- mated total atmospheric.oxone. Introduction It has beenstheo~retfcallt'y~ d O ns4ated (C~all ~ and Kealy, 1978] that total ozone can be expected columnar content constituted the basic ozone data used in this investigation. These data span the period of April 10, 1970, through January 31, 1971. [Prabhakara, unpublished data 1971]. ~ Analysis Procedures The ozone columnar content data were parti- tioned into geographic cells (5' in latitude by 10' in longitude) and averaged over 1 month intervals, to obtain local averages. Assigned to each of these local averages was a standard deviation, calculated by assuming that the data in each cell are statintically independent and have a random noise of 6 percent of their value 3(estimated short term accuracy of the IRIS data). The resulting pointwise description of the global ozone distribution -as assumed to have r
Page 143: wrm95d00
50335 26~t3 vi Tos :.t...i.i...._. . iL TT~.•'..~ro. ~n4 "?5^!37y 2vIS .s: i• .., s~, r,$3i<- .nr..c;., ~'- •~A~~.f..wr..i~ .w• a i._ . •u.• _..1..'~i.4 a.~-~ VYw~• 'vwaJ 1104~`1i:c.~_t rt;:i`....r-__.~t ~it~ '~ =...~ {•~ ~ : Zrr_ -'1 / ( s..p Lf~w~~J /. :~i : ~ .~.4s.t4 0 0 S Q ~ 0 0.2 4 9 -3 2
Page 144: wrm95d00
50 335 2650 .. III Me 9-74 SdLVENTS--HEALT1i HAZARDS/SAFETY GIIIDES/II3U~7SIPRIAL TG~ICOLi}G'r/ S.F. TOXICITY--CHMICAL C0MPnUND. ' -.~~er-a for a recommended , . . . r~ri~ . . . OCCUPATtCNAL EXPCSL RE 11 TO , Gl. S. Public Health Service National Institute for Occupational Safety and Health 1973 „N• eQr%I'o/V 0 5 0 0 n 0 2 49 3 9 l F I
Page 145: wrm95d00
r °d ~ZZ Z~~s: sLqQ~~J 'P*a V1S ' IM;!FI:;''fN d~23AT3y Ro ~r~i v!',{YIS fn!7a~
Page 146: wrm95d00
73 IZ Re-74 Biophysics 17 (5) 779-83 (1972) S'p' (Bfofizika) ELECTRON MICROSCOPIC INVESTIGE1TION OF THE GELS OF SOME BIOPOLYNIERS# YF. M. BELAVTSEVA, I~LK ~ s` D. B. IzYuatov and M. M. GM*ra Institute of Elettutuoorganic Compounds, U.S.S.R. Academy of Sciences, Moscow (Receised 27 July 1970) For the electron-microscopic investigation of the structure of the gels of biopolymers the method of freeze etching has been applied. It is shown that characteristic of the structure athe gels of gclatine and calcium alginate and pectinate is the presence of fibrillar structural elements organized into spatial networks with different degrees of orderliness. The degree of organization of the fibrillar structural elements in the spatial networks of the gels depends on the concentration and falls on transition from the gels of calcium alginate to the zels of calcium pectinate. The gets of getatine studied have a disordered spatial structure. Ttm possibility of modelling the structural features and the complex of physicochemicat. properties characteristic of biological coznective tissues was demonstrated by Thiele et ot. For the modelling of biological tissues they used tbe gels of biopolymers 'with ordered structure-. The investigations of Thiele showed that such gels can be obtained by directed diffusion of inetal ions into aqueous solutions of polyelectrotytes jI]. The i
Page 147: wrm95d00
50335 2649 1~ E , . V . ~=~~ c,Co- ~.. s,~= ~ hl EXTRACTIO~I-CIiItOnIATOGItAPHIC DETERMINATION ; OF T~IIOPHENE, CHLOItOTHIOPIiENES, ~ ' AND BENZENE IN EFFLUENT / . ~ ~Z: 1. Chalaya, L.(S) . Dfikhailova, A. I. Mashkevich, 0. A. Egoreichenko, and~`'~b. M. Polishchuk UDC 547.254:547:233:543.8 r The chlorothiophenes are intermediates in organic synthesis. Thiophene, benzene, and toluene are the main impurities in the reaction mixture during production of the chiorothiophenes. Accordingly, the ,_ need often arises to determine them in industrial effluents. Gas-liquid chromatography is the most suitable method for analyzing aqueous solutions of the muilti- component mixtures indicate~.t.. However, direct chromatographic analysis of the effluents in question was complicated by the hi;h sodium hydroxide and chloride contents, and also by :he very low limiting permis- sible concentrations of the chlorothiophenes (0.03 mg/liter) and other components (lj. J U' . W
Page 148: wrm95d00
TOBACCO--CURING.'--RUSSIA/ETHYLENE/ 77 VII Ra RJR CLASS NO. PAMPHLET 77 VII Ra Rakitin, Y. V.; ftff';;NW--TW Mikhailova, T. P.; Nikol'skaya, A. 'I. (K:.A. Timiryazev Inst. Plant Physiol., Acad. Sci. USSR, Moscow; Alma-Ata Tobacco Sovkhoz, Alma-Ata, Kazakh SSR; All-Union Sci:1•Res. Inst. Tobacco Aztec Tobacco, Krasnodar) ACCELERATION OF THE PROCESS OF CURING OF TOBACCO LEAVES WITH THE AID OF Sov. Plant Physiol. 23 (No. 5) 905-9 (1976) (in English) *Keywords:* ethylene, tobacco, additive. It` Is demonstrated that ethylene powerfully activates vital processes in tobacco leaves and can E i therefore be used as a highly effective agent for stimulation of the curing process, which is an 1 { Important stage in the postharvest treatment of tobacco raw material }.
Page 149: wrm95d00
COxRDSION AND ANTI-CORSOSIVES/ TA ev fWj~ 1 d A11 an 1966 . •„ oys ion o,~,,e a a (1Caaonya meullov i splavom)
Page 150: wrm95d00
! VII 50335 2656 ~ r1i Iuda'.-~, Zy~=~ Y11LUl,_' ~ x:~L+s•:• ~•+jLls:.a ~ Y 1 VwaS/VV L•u JL Zy1L~7 T~G7 ~.'s,i Y^ T= n:.~tca~ .--. 1
Page 151: wrm95d00
N 50335 2626 r,; r A M:: 1; i2t.1 n-14 J J.~«e Jl- .1.0-. !.~ YllJ-i4 (19 y - i --~7 73 X Rc, -81 ~.:.:~...~~,. ® V. A- b1 tht OOnne 6ldtlaWks1epa ~Od fa$e preadhgpoQecs spest ~~ ambet d mWonce1 wMe Ia*ed Ift the consess of rabbits and the tq,111F j~e~ioas oboer.,ad, qya rsqwbmmts were pariacmed, in ~' put, r c1 at so t hr zwide mkq cf qwKW staffia, is p.rt as s pu. """"w =MIY 4f &e iftw tulCaw d dk! CWiDd t1MItG. M! - nolts fR !ompt'lEdja dlw table below. Uairsa ot6e,rnrbe Miftd, 8.I mL af the sohttim ct test sabstaace wn uajccted i~traoa~a sing a i/t?5-27 gwMe ncedti and tuberculin WriW Ocxa~io~a~r ale aate:IOr chamber w.s entermd scadentiq, in Moe a~s r~ i2a pierfatent ederastoos bnlftaE the comes A~.rhicti aaaZd tie idarti6ed dmc@By =d the tabe po.ifive coeneal ..~: oa ~aeded: T~e e~aeE qa~y i*ected .~ ~imits of ~ oa~' OiIS a.-0.2 = w.s of 1es importance tium tbe concentratian of the " injerted msteri.l. Seooa&sy Wectiao .ras timcammes. A=idmtal ~ fn' eE air bft tLr cornes did sot iwase tbe smi" ~af the 3* "I --h
Page 152: wrm95d00
50335 2654 - TOBACCO--St4ORE--PMCX;IC.AL TESTINr./TOFACCf)--S?MORE--NITRO(;F•N COMPOLt*IflS/ 77 X Mi TOBACCO--S.:O=--TAR/ RIR CLASS "-0. PA"f'HL`iT 77 a;fi t,p,) tltzusaki, S.; T:I:~sF'ina, T.; ~~ (Japan Tobacco Salt Pub. Corp., Cent. Inst., Yoi:ohana, FAC"TflPS AFFrCTI?tC .v`~^1iTAGl:NIC ACFIVIIY OF CiGA:FTTE S'.:JF:E IN S"L:'OtiELLA TYPFlIttIiRlUci TA 1538. ?'utation R,-!s. 48, 29-36 (1977) (in English) _- 3`Re.,vords:* smoke condensate, str.oke, constituent. Smoke condensates from Burley tobacco, brignt-type tobacco and various brands -of commercial cigarettes were tested for mutagenicity by using a micro- somal test system with Salmonella typhimurium TA 1538. Smoke condensate from Burley tobacco had much higher mutagenic activity than that from bright-type tobacco. Increased mutagenic activity was observed with smoke condensates from Burley tobacco grotivn with increasing amounts of nitrogen fertilizer, and from commercial cigarettes blended with Burley tobacco. There was a significant correlation betcveen nitrate content of cigarette and muiagenic activity of the resulting smoke condensate. The results suggest that nitrate in cigarettes may influence the foru~,:tion of potential mutagens during the burn. uag of a cigarette. £1 Sn r~ 0 0 0 2 r4 9 4'3
Page 153: wrm95d00
50335 2660 . . I TASTE--TESTIrTr,--*%TR()flc)LtX:y/ Ann. Tcchnol. Agric., Ig77, 26 (4), 373-4i8. (r99 ~ Z, `; Prdsentation synth6tique de diverses m6thodes d'an~ :~ alyse d d e onnes fournies j d de d par unuryegustateurs Eet C_ FI,AINZI'• Surrey ol the nucthods o/ analysis o/ taste f,aurl data In this papcr a.<urney of the nlethods of analysis of taste panel data is given. With only one variable !?rictillnan's two-way variance analysi, is colnplcteti ..•ith abnle specific tests: multiple conspariaons, prefixed or+icr; the links brts.een the varions statistics are shown. \Cith several variablc.4, a lot o[ classical nlethr„ls of multidimensional znalysix are pruposed to take into account the entire information; beside principal culupunents analysis, corrc,lxwrlence :ulal%. six, Canol:ICaI variate analysis sonu lnetluxl.r such as procustean anal,•;i+, principal ccwnlinate analysis are I1.+Cril,~tl to c'mt1171Ctt• the whole set of statistical tools. The iUlrOrttlnCe is given to siluilarity and dis;i:u%larity between methods to give to the user the jxls:u6ility to cllouw• the best method well fitted to hi.k own problem. 0 5 0 0 n 0 2 4 9 4 9
Page 154: wrm95d00
1 0 6 dZ 0 u 0 0 S ~p , •0 •11 'metw8-uoasuTrj t*T=aa~K 30 WTa2oTM) Y 696T :a*w 'M Wr7tTM Paw aoTwfagQ VoT3a=olux DZinTaS I :tuQWdoZotDa 2aapoid pzm qax9sao-d '[uedaao:) o*ovqoZ SpTou6sn •t' •8 AQ 'Q3M5 attZT92.T.1'f V `SZLMIZoSI 8N8I4Z4S d0 LLIaIxQ.L ttoTsu+?Q naTZtuao3n; vauspS 's3acsvaxedea :gassrdotsnaQ 2oepoaa pmi tp"atos "Lusdaoo o*og qos splou4n • r•,a • d• S (6961) zzz~
Page 155: wrm95d00
AIR--POLLtJTION--CARCINOGENS/AUTOMOBILE EXHAUST GAS/CANCER-GEOGRAPHICAL/ LUIdGS--CANCER--EPIDEMIOLOGY/ASBESTOS/CANCER EPIDEMIOLOGY/ RC 267 In 1977 roceedings of the Second H anover AN D CAN C E R International Carcinogenesrs Meeting IN MAN held in Hanover, 22-24 October, 1975 EDITORS U. MOHR D. SCHMAHL TECHNICAL EDITOR FOR IARC 1 W. DAVIS I 0~ 0 '&T9RN`AT1 N A8E4Y tOR RESEARCH ON CANCER WORLD HEALTH ORGANIZATION INTERNATIONAL AGENCY FOR RESEARCH ON CANCER AIR POLLUTION . I
Page 156: wrm95d00
50335 2659 • - CHEMIA ANALITYCZDIA - ~ ~~ ~ 73_(19T8) 03 • . STUDIES ON THE QUANTITATIVE, DETMI31LIh1ATION OF'PYRIDINE IN,' COAL TAI?S. I. T,I;~: ALZaALIIJE HYD ROLYSIS ' OF THE PP4DUCTS OF TI3 : IIEACTIONS OF SOME CIiLO tiONITROCOMPOUNDS WITH PYRIDINE Romuald ZALEWSKI'), Ewa ZAKRZEWSKA'h and ••) ') Institute of Product Determination, Academy of Economics, Poznaii ") Department of Organic Chemistry, Pedagogical School, Czgstochowa Thus far any method is lacking of fast determining pyridine bases in some fractions of coal tars as well as in the coke oven gas. Some colori- metric methods based on the extractive separation of pyridine bases from above products and the reaction of extracts with BrCN (the Koenig reac-. tion) followed by addition of either benzidine 1) or p-phenylenediamine 2) are limited mainly to pyridine itself and, moreover, they are time con-- suming. Some more refined methods are based on the gas-liquid chromato- graphy technique''8), also combined with the sorption on ion exchangers T>. Ve hSVe~or~de~d~h ezea io of ,4 initrochlorobenzene with pyri- dine (the Zincke reactiSn) 11~~s luit~l~for quantitative determination nf. th.e, mi,xti
Page 157: wrm95d00
RJR CLASS NO. TRANSLATION Kohno, M.; Matsuo, T.; Yamaguchi, Y.; Saito, R.; Sato, K. *(no affil.)* STl}3i ES ON AL U PiiO ' HIDE AGAINST STORED TOBACCO I CTS. (III) APPi,~ICrA2:,WST OF NUM PHOSPHIDE. Nippon SembalmToms%a Chuo Kenkya Hokoku 1974 (No. 116) 35-42 (1974) Japanese - complete English translation available) *Keywords:* aluminum phosphide, tobacco, Additive. i ; Some chauxteriain of a nein typo u{ atumininm phoqhide drug, vis, the dccomixMition rate, tbc `` paucrn of ttiaavua si+srading frmn opcued warehonx and the amount rd pLnsphine or alumininm ` phrr:irhu'.e in fomiratal tohnai» kares or drut residot..~a, were mcr:jined iq the xt:eal fnmir;ation {` pr.xtices of tol.~a» warclwc>ses. The fumigation .raa carri.•d out under both of the re'ati.Ac cool, ; dry arul vrarm, humE-1 efim-Itie cwtdition ~ _
Page 158: wrm95d00
S S 6 dZ 0 U 0 U ~ t? {M+GY~ 1ti•7rt `7 7tA~+ I+l2m,'1ttf+} ~' •y- L.^i c:°.-.T.. aSI SM.W: 3' R,'lWa9 "vHM • H • 9 • pag_m 999= SEEDS
Page 159: wrm95d00
Op- f~liC P/,~`1?N9 f S N%II ew~37- -. t . .. _ lorR*ir Technology Fruit Juice Techn0io~Y T~'37 o ~, ° I 9)Q 1970 ac PDC W- x ° 0 S 0 0 n 0 Z 4 9 5 7 Milton Gutterson
Page 160: wrm95d00
5033S 2672 TP 370 Go Gooae, Peter G. TOMATO PASTS, P= E, JUICE AND POWDER, bp Peter G. Goose and 12sqmond Binsted. 1964 151 p. Food Trede Press, Ltd. London 05 0 0 0 02 49 6 1
Page 161: wrm95d00
~ TP 370 3 isV 50335 2669 GooseT Peter G. TONATO PA~ 8, MPIM, 313TCE AN3 3Oi3D-tR, bp Peter G. GOoSe and P.aymoud Einsted. 1964 151 p. Foud Trade Prasa, Ltd. London ~~ t} ~ o 0, 2 4 9 S 8
Page 162: wrm95d00
XX MeF ; (1970) E S.P. 50335 2665 8. J. Bapao2ds Tobacco Co., Ruoarch and Product ravelopzi.at Dopartmauts, Scicarac Zaicrr--tioa Divit3on ItrDITti.*.'DAL MLa". C 223,. VEi,ET.18LE8, bp B. :!. Co3ao3.ds Tobacco Co.,Reacarch and PrO-d "t Gas*].cl;z=t Doparts. Ze, Sci-c-acQ Zafa:mgtian D3via :oa, and LBMoy Ifeo't. 1970 A collecticn of cute:is1 Wiustoa-Stlm, N. C. ! 0 S 0 0 0 02 4 9 9 4
Page 163: wrm95d00
0335 2661 I Received November 7, 1977 SlMlfARY I i wicrosomil_system analogous to those used in various carcinogen detection .oSEIO©02 4 9 9 o CANCBR--CAUSl1TIQlt B!! CNEMICALSt HYDROCARI3ONS--METABQLISN/ ' ° 78 II Ei ~ DIFFEREIICES 6g71~EitPRODt1CTS OF 8IFR1ItK OF 7,12 IIETH.YLBENZ[ajANTFiRACENE f0 DNA IN t+qUSE SKIN AI~ IN A / RAT LIVER MICRtISE1MAt. s1fSTEM C.A.N. 8igger, ~, and A. Dipple Che~ical Carcinogenesis Progra.~, I~I Frederick Cancer Research Center, Frederick, Maryland 21701 _.._..~ ~13 147 Pates 224-235 MoR iQ, Flo. 1, 1978 dFOG#AAtCA1, AND eiQPFtYStCA[ RESURCH COAAMUNKATtf?NS ` _.- Hydrocarbon-deoxyribonucleoside products from the DNA of mouse skin exposed in vivo to 7,12-dimethylbenz[a]anthracene are chromatographically the save as the products formed in mouse embryo cell cultures. These products, which are known to arise through the generation of a diol-epoxide in the 1,2,3, 4-ring of the hydrocarbon, are chromatographically separable from products that result from reaction of the K-region oxide of this hydrocarbon with DNA. How- ever, when 7,12-dimethylbenz[a]anthracene is bound to DNW in the presence of a.
Page 164: wrm95d00
RC 267 In 1979 f.N6rINOSEtIS(1 ist)/ClNiCfR--CIkUSJtTItN BY CHEMICAL.S/ V1IYORLD HEALTH ORt'IANtZA'IIQN ' ATIONAL AGENCY FOR RESF ARCH ON CANCER CHEMICALS AND INDUSTRIAL PROCESSES ASSOCIATED WITH CANCER IN HUMANS v'IARC MONOGRAM Vol~ 1 to 20 Report of sn IA1tC ad hoc Working Group .rhich mct in Lpoa, 15-17 Jasnaqr 1979 to advite the Directar, IARC, on cbemicah cwckoSenic for 6umaas Prepared by : RALPH ALTHOUSE JAMES HUFF JULIAN WILBOURN ptcmber 1979 INTERNATIQNAL AGENCY FOR RESEARCH ON CANCER LYON , 0 5 4 O 0024952
Page 165: wrm95d00
50335 2671 ~ TP ~ 497 'IT Treasler, bonald Kitieley, 1E44- FkUIT A.14.1) VE -GETABLE 1t1IC. PRvCESST3d: TECH:wYAGY, by Doraid K. TrApsler ar.d tdaynard A. .toslyno 1961 1028 p. Avi Pub. Co. Fdemtport, Conn. Includes bibl io ;xaphy.
Page 166: wrm95d00
80 III Yo .~~ . . . ...~ ~ ~~~'~" Cljlu uplilx~rioprr (iff ift;1'(Xfo silillplex u!Ei Opllft7l.:tll'ilm <<r aejmrctriours minulol;rtic+cnt Nawt"r tr ". s.eatc ~ op1o. I. oufi.ierM.tttlasti M.etlra Oa#atioo d.. Ar6l.Baealoa.-V V/ Ar..r of Ye S&Apias wemd iAi..rtwis.H.n ./'dr.rw.ewr.y*ic arym.eiw~.. iyrX. T..rir.1. tA'..fwin ..d L.C. Sabatt UaW q"Wid dd =Ud. Siwplei s t' a~e~ts.cif le.e~i.as ~ #~+d~ rer X. t9.wi., 1.~ I* ~~ ow w.k r to iwr. ReeAriA.: tl-Y-1l7!! &I '~ tr MrrtNN map1nc adr.4 ~. 6wt ...diei..e .1 pwai/wswe !w vaAor *r..i- w N wtaM iiawkx MeMR M Nr.N.otiwie.di.M tierAMw aar MYut, a ..~t.ai..r is pqraas aa fO11TlI/W IY..V d ib do .rw ..w..r#r qrie.w.4r W*dft r s rMks Mw!a N~•~ a•wrt - ri. !1 pw wm.MSptt. M pu. i r ..--+" b. ~.pr.efra. p..io do www tNMi. & p.. t'... +M..eMe d.- wt.awh.* M Mr.ib do L tn.Mt i t. b}wN8 ewin. il..M~./T% i1g.aM.mwaq!}.Gwaa..mr yiMaaa dl"wa w1.i e'Ms .lMik pt 1. ywifiiI i s f tf. M i a M ~~~d D ~ ~ motboub .rIRmM, 0 0 0 0 2 4 9 4 6 wlr.re r.pmftw fr) a.i or ~ pwrrr !t t. +.wM•• ww4p ! .Ltw. N *beo/on.,Masia by ~ a. i~ b.w. w~s~ .u.M ~.r., R.iaa R. i', 0 i. tA. ./ E+ + .wo6orrAoa .t 1r. Mw nqn. M•" tl.a 7.itlf anW M Aarf fo./ a a~rtiTr ~ •~qa M 1M .aNei~ A~ .rRt~/ da. hr WeWd~t w@*Ad. a.~refn tslh .MIAoft rr. th. ~ i.o.Mli, M~ fy ht t4~. Mi waAad Mu/~ iint rM.~M ~' a~nat ~ r.i atwlqtew tWw ~ M p.oliaht wn.
Page 167: wrm95d00
Goose, Peter G. TDVATa Pj,~Zi`S, PURBB, TIITCE A:~7D pi~:UER, by Peter G. Goose eud }ta7mond Binsted. 1964 151 p. FoQd Trsde lp-ms, Ltd. Loudoa
Page 168: wrm95d00
50335 267• ~ TP 370 ~ Go Gooae, Peter G. TOMATO PAu T2, PMS, JUICE AND P0k'DgR, by Peter G. Goose snd Ragwnd Binated. 1964 151 p. Food Trade I=ress, Ltd. London ..-.~.-._.,. o 5 o o n 0 2 49 6 3
Page 169: wrm95d00
, . 3k . • 7t`~tr..,t1, ~ ~io>a3/.~ !? ~9?,~'~ C~~~` ~t~Q..~ 1 77 III Yu REACTIONS OFl'fIYDROPERO!C{bES. XX. ROLE OF S[JBSTITUTENTS DURING EPOXIDATION OF CYCLICfOLEFINS BY TERT-AMYL RYDROPEROXIDE CATALYZED BY bWLYBDEHUM COMPOUNDS. B. fl. f!)paes, ff. A. 'Paurc.wxac, .7. B. Cnupusux,. f. A. ToArmuxae V, P Yur ev; SPr'riXAin =tlO3tM Re.ettoas .i bydropcreicides. X7C. R.le ot _ ftilirNtttests during epo:idatioe of cvclic olcf'los by tert-sroyl +~+Ne»zide eatatyaed by molybdenum compounds. Yur'ev. 1 T p~ Culiunas~• I., y~~tikhin, L V.; Tofstikov, G. A. (lnst. ~bla. 1)fa, USSK). Zh. UbahcA. Khiet. 1975. 45(1Q). "-312-17 obw . F0sitLadp-maNh.-1.6dune by EtCt00H)UkrMdC01. . ¢ 't s w ~~~ ~1~{feC:CHa) and 70'l It (R - AleC:CHr) whieb s~ 1a~01 - AkrCt il P'~aestlt-i-eeg•ve 0 ~ +rbie! 05 0 0002 4 934 . eeas tedttad toItvs aanatie p-menthane-l.9-diols F.poaidn .f III tR s CHAAc) by PhCt}AH gave 80^.. I(R - CHAM .nd taa(P menth-l-en-9 rl)eiuntitr~s l096 It IR & CH O:~cl. 0aialnL of (oiio+ced by.cetyLttiutt gave I11 (K a AcIX:Ha;H11e1 which wos ;=by j tCWOH)Aleralo(CO)e to =iys 1WT. 11 /R ~
Page 170: wrm95d00
50335 2679 Joslyn, Maynard Alexander,I9t?4- Food processing operations: their management, machines, materials, and methods, by Maynard A. Joslyn and J. L. HeLd, in collaboration with selected authorities on the management, machines, materia2s, and methods of the food industry. Westport, Conn., Avi Pub. Co., 1963- v. illns. 24 cm. Includes bibliography. 0 0 Q 0 0 2 49 6 8
Page 171: wrm95d00
50335 2675 -.Sffiw~ TP 370 Go m~ n r~~crs__Man~ farr„rin~ egui.pm Goose, Peter G. Tt3MTU PA fIZ, s"35M, .FtTxcE AND POOZP., by Peter G. Goosa mtd Asywad Sinsted. 1964 151 p. Food Trsde Ptsse, Ltd. London
Page 172: wrm95d00
COTTON/KEIdAF/OKRE!/?'IITMEG/Ci.OVES/Pitnento/GHAVArPLAVICARPA:PASSIt?N Fk(JI'Tj --__ PASSION FRUIT/PErPER/SESAME /LIPX /COFFEE/LIIKO,t/GRAPEFRLIIT/ORANGEjMMM1ft EGG-YLAPIT/P()TtiTO/COLA,; NITIDA:KOLA/C0COA/'I'y'A/JUTE/RAMIE/CALABASH/PO*iEGRAAiATE/ TOBACCO-BOTANY/COCA/ QK 495 Pu 1968 UTROPICAL CROPS Dicotyledons 2 . ~~ J. W. PZJRSEGLOVE ptofessoc of Botany and Plant Pathology Univetsity of the West Indies Woidad JOHN WILEY AND SONS, INC. NEW YORX A If. lE'r/, I J. L`, {CY os , J ~---~-~-~:---~--~-~-~~~---~-~ 11*rl"r F A ) - t`! t ~ k) t --~..'` TrI-T r I a 5 Q 0 ~ E1 2"d ~i 5 3
Page 173: wrm95d00
50335 2670 A xx MeF (1970) S'.P. 8. J. Bmyaolds Tcbasco Co., BacearcL and Product IIevalopmnt Depastm&ats, Sciesca Iato=stfoa DSviwioa IZIDLPIDtSAL MDS. C 223. QECLit1BLES, by 8. J„ Baymolds Tobacco Co., Sezsearch t~,nd prodss:t Da,va13pa=C DepartW:ato, Sclunca Intonmar3.vn Divisic+n, and lGaRoy H$ok. 1970 A collection of aratarlU Wi=ton-Sa1aa, N. C. 0 5 t~ 0 ti 0 2 4 9 5 9
Page 174: wrm95d00
CoAsa } Peter C. 3GMa"T4 Pi'ya?'r, PDTADmt' *i)r Paur G. Gons-a and Upmorrd }3lrtstnd. 1964 151 P. Food Trede Press, Ltd. t..ondon o500 00.249`67
Page 175: wrm95d00
50335 2676 ' TP 370 MOM Go :, AND PQU Gooae, Peter C. TG~'M PA5TE, PURF.E, .TUIGE Ah'D POWDER, by Peter G. Goose and Raqmond 5lnated. 1964 151 p. Food Trade Press, Ltd. t.andon 1 s U~t10~02 4965
Page 176: wrm95d00
Carncross, John W. 1964 AMERICAN TOMATO YEARBOOK7 a=vao.Pjgol. 21 9 Ref TP 370 Ca 19644,41 44 pp. C. Stedman Macfarland, Jr. Westfield, New Jerseil .4 t3~C10 t~02497t1
Page 177: wrm95d00
50335 2684 ~ TP ~ 370 j Go Goase, Peter G. :~OMATQ PASTE, PBREE, JUICE AND POWDER, by Peter G. Goose aad Raymond Binated. 1964 151 p. Food Trade Presa, Ltd. London 0 0 s 0 0 n 0 - 2 4 9 -7 3
Page 178: wrm95d00
Schade, Huns PATENTS AT A GLANCE, A SUIVIEY OF SUBSTRA.:'TIFE LAW A29D FORMALITIES IN 45 CflUid T RILS . 1964 42 pp. Carl tiep~~s Verlag KG Germany 05QOCt4.~4~1 i
Page 179: wrm95d00
50335 2680 "a •~Ri...Y~~l~ i'S~'SS.VL -' 1 ~~sl I ~. TEC4i.~ifl%OGi.`°•7: kA.`:Dt3t7OK j.7ti7 °variouaiy praSed Ohio State t3nivcrsity Cohr4bus, Ohio and Ohio Agxicultural Resegrch and T3evolopateut Center 0 5 d_0 tl 0_2 4 96 9
Page 180: wrm95d00
STREPTOMYCES ANTIBIOTICS/ BOTW -'VHySIOLOGY =_AANT._ .CEI:tS" AND"tTISSiTErS-=GROW'i'H%AIJTIBI(JTICS / 73 II To Boe. Jtag. Tokyo 85: tt9-..10a,(197'1 (59f ~~ Electron Microscope Studies on the D•iQrphoacnesis of Plastids ; - ~ 1 VII. Effects of Streptomycin on the Development of Plastids in . ~ $L'SIIMtT Tu] ALiA ~. DtporiAatl of BalnNY, Fueally o/SeieKU. Totyo KyoiL-et Uxic,ersity, OIarLn, Tokyo 112 Strcptomycin sulphnte !2 ttg/ml) did not affect the formation of proplaatids or the elaboration of prolurnclktr bndir•.. Thc plastidn of the streptotnycin (S.II)-treatcd cot.•- Iedons crnntained both crystalline prolamcllar bodies and ribowmes, and were undis- tingui4hehlc from the pla~ctidw of the w•atcr-rrowtt cotyledon. flo.r•e.er, plastidx from dark-grown S3t-ttratcd cot}•lexloos were no longer able to ditYctrnti>rtc to more advanced stages of devcloptncnt. even after esj". nte to light. The plastids of light and dark- grown Sli-truzted. cot.-ledoers often cuntaitad prolnmellatr bodica and abnormal giant grana. Var•icoatiurt dcvclohrl iu the cotyledons germinated in lloaclnnd's solution plti4 M The plmtkLs in lwlc enxn tismtc rnntairKd atromg-lnntellse and one or two giant gn.na, .ncerr.u in tJruse of lraic yellow titiiuc, rnanv attniophilic Rlobules, large vacuulcs aird cryxtai balica were ob>enrd. It i.~ -uAy,e-sted that the formation of pt•olamcliar bodies nu.y dcpcud on c tfjplasmic protein synthesis .t•hcrens functional strouua- and _.graua-larnrlLto ma} rir1r•ncl om rotein s~7tth!nis within the rlastick. The inhibitors 0~9 0 t,~nct ot}i p~ pn/~cin %-ntlis ~re a.~ed as a tool to test this h}•pothesis.
Page 181: wrm95d00
50335 2685 4 ! xx B1 1 (1969) B3.&nchflald, J. R. TC}MATO PURU, CADIHBD (Jcn. 1969) V^rxf PIFo, InorP~f~,i_.a~r, ~.a~r,~ C~tt'+~~; ~ ? 7~-?4 y
Page 182: wrm95d00
G LC 9 Y/~ ~/! '/G C r? 1~.7 ~ 1ai¢ S.S I n N FR(,( /~ j V335 2686 SB 369 Fi 1974 CITRUS FRL'ITS/AGRICULTtIRAL SCIENCE/UERBICIDES/INSECTICIDES/FRUITS/ VEGETABLES/FUNGICIDES/ORnNGE ~.7UICE EFR'IT/MANGOS/ PAPAYA/PLANT SCIENCES/ FLOWERS/ 'FEAC/fESI 'j'XOpicR~ ~:4t[tf'/ ,j,,L4RIDA STATE HORTICULTURAL SOCIETY, 197~1 'EiGHTY-SEVENTH ANNUAL MEETING ~ OCEEDINGS of the ~ FLORIDA STATE ~ f ~4RTICULTURAL SOCIETY held at Miami Beach, Florida November 5-7, 1974 o5oooo24--975 ,r.
Page 183: wrm95d00
50335 2683 G;a:ld, ttii?bu. A. .n.. T7 nA~n ~ TT "r.,z u._ n • c~..~ nw.s .~.. . TECi:NULLGIST I•Lyi1DH;}i:K ...n . 7V7 ~ variousiy p~~ei Ohio State Un<versity Co2i::i~bus, Ohio and Ohia Agricuiturak RC«osrch anc! Dovelopaent Center 0 5 0 0 n 0 2 49 7 2
Page 184: wrm95d00
iiaiatis, C1naslsaa BA-Lxler, 192it- tligr.`s4odas; tha paradox3c:a1 plaao Chsrles B. Heiser, Jit. San Frroncisro, .t'rp-eman [1769j 200 p. ildu:. 23 cm. ~;A S,jxies of L•ooL3 In t,+Qjogq3
Page 185: wrm95d00
WWOMICS/ACTA NORTIClLTURAE No. 98, Mar. 198Q}` SOILLESS CULTURE/PLANTS--SOILLESS CULTURE
Page 186: wrm95d00
TP 370 Ca ~c _ 1, 1 ; Un, Carncross, John W. 1964 AMERICAN TOMATO YP.AP.BOtiR1GdV, 1964, 44 pp. C. Stedman Macferland, Jr. Westfield, Piew Jersey Ref TP 370 Ca f ~2 -C i t3 5 0 0 El 02 4 9A 4
Page 187: wrm95d00
50335 2696 ~ ~L~?C 3 h W a racrcas, o n . 1964 APMC.AN TtY;sATO YEARBOOK (~9-L•.41 t5c} 1964jr ~',LrI 44 pp. C. Stedman Macfarland, Jr. Westfield, New Jersey Ref lC-0 _. r ... ,----- -r ~- - v 5 0 o Q~I.~ 4 9 8 5
Page 188: wrm95d00
ASPARAGUS/BEANS/CABBAGEX -"./CARROTS/CELERY/CORN/CUCUMSERS/LETTUCE/ CANTALOUPES/ONIONS/PEASJPE1rPERS/POTATOES/SPINAC&/SWEET POTATOES/ ERMELON/ 5V George W. Ware U.S. Department of Apriculture, Retiredj Formerly, in Charge, Fruit and Truck 8ronch Experiment Stution, University of Arkansas (a Professor of Ptant Physiology, Emeritus, College of Agriculture, University of 111inois
Page 189: wrm95d00
CBrncross, John W. , - . 1964 AAMERICAN TOMATO 19641 44 pp. C. Stedman Macfarland, Jr. Westfield, NeW Jersey .~-..K,F,...._ . ._ - =~- 0 5 0 0 t1 Q 2 4 9 8 6
Page 190: wrm95d00
MI C 50335 2677 "-- ----:-- , . a F-D-~75 AWIMM 3 lrW tl lt UINQ~.'l;li1P %'.~S'6;,_9M ,,,-aCoop. Ext. Programs Univ. Sdisc. I974(2604)2pp. (Apr. 1974) w..mma.re 3Yf!'rOMS AND EFFECTS a tlww.a% Umaa .ws'+o+kad araas rinr app.r .. Ma la..... 7haa e..prar svob laqr turn baaek .d prarwa,Mik* sti sy hd yr..vy on d,e up~,w :dWs T1* +voa nwM ftmnw w9.. bue "wnl Ss an a.LyN baft .sr caaa ie m twn y.I1orw ad drow On ya.~ aaww Wa eacte.sunn may >1.w/y G+rm sam. " vrtiabs. Stun eanksn and s>yA 1..t las ww aaaM on olo.r pbrm. or ew hut. ww eya ra~.a +ooea nsc +avew. lnwradd Dp a narrow wer-.oaked Zone. T/as aW a ri+ft acx.as is a..wec;rtKs Wl.a seab. Th. sas M+a7p tirKA sh.y a.O abouc ona-eownh wwa, . r.m fn 4'i&wqx aW ov+.crua slijhay into eM !M N!N truie. The ea+.d vot acdcs as the inw are ra"yratm carrg tAf lUnQUfdiflg 3kifl to npIsL W/I.A to:Nfi Q!f ~WI HMlthaf. a irW bIoedNlu ans is tw a~.d. Hipa truits arr • eat ~1iewl. E, LMrada .W TMr_ MMM a we sty..f aaeftH.r oa Th. meM aee eNnf. Yw 7M pnpra a. Mhh" 1rMM .wd /N.~ a ..u~, .ca.wr .....•.ws.. sr1.w a.w+Mr .# WDw. 0
Page 191: wrm95d00
Gcu3.d, k3lbur A. TC~ -A!.''0 F'RCC::SSCr QIle';,ITY CL3'.."'_'P,OL TEGHNOIAGIST tiA23DBC0K 33~y Variously paged Ohio State University Coltubus, Ohio aad Ohio Agricultural Reaearch End Devalogment Center ~ - :~7 ~ - --- ~soooo.2 4 9a7
Page 192: wrm95d00
RICE/SORGSUM/MILLET/MAIZE/BEAhS/VEGETABLES/CASSAVA/SWEET POTATO/YAMS/TARO/ ~~EPPERS/BANANAS/MANGOS/QRANGE CITRUS FRUITS/COCONUT/COFFEE/CACAO/ TEA/COTT01+~/JUTE/KENAF/.SPICES/SUC.,"'.:~NF~tUBBER/VANILLA/CARDAMOM/PEPPERS/ UNITED NATIONS F- AND AGRICULTURE ORGANIZATION, Rome, FAO Agricultural Studics No. 93 HANDBOOK OF PLANT INTRODUCTION IN TROPICAL CROPS 1~ Edited by J. LE(SN Plant Production and Protection Division FOOD AND AGRICULTURE ORGANIZATION OF THE UNITED NATIONS ROME 1974 / . 1974
Page 193: wrm95d00
50335 2700 TP 370 Ca -~/a -o r ~ L;,N y 1 " Caracrass. John W. 1964 AMERICAN TOMATO Y".ARBOdK 7 0• v.'aa1(01- 0'. 1964,"•?':? 44 pg, C. Stmmdman Macfarland, Jr. Westfield, New Jersey Ref TP 370 Ca ~~- (cQ ,.~.~-..p.. (J t 0~~ p a 0 .2 49 ~ 9
Page 194: wrm95d00
50335 2691 .~._..,,-....~.~ .~~,.,s.~,.r.- ..~.~..aa kEEDS---CON'TROLl PEPPERSAmW1MWIs6GPLAN'FSt.---.-_..•. =_._. ---- :_ Agr. Exp. Stat3'ons-itawaii-Special Report (73)1-20(April 1974) 74 II Ta ' HEItIiICIDE EVALUATION STUDIES d _=-r WITH SOLANACEOUS CROPS I` I-IAWAII i J.S. Tanaka, R. R. Romanowski, Jr.. and J. A. Crozier. Jr. ` It`TRODUCTION The shortage and rising cost of labor have made chemical ing an important cultural tool in Hawaii farming. The solanaceous crops comprise one of the most important seaments of the vege- table industry in Hawaii. Due to their long harvest periods. these crops require many hours of hand cultivation to remove weeds. The herbicide trials reported herein were conducted to deterrnine the feasibility of using chemicals to supplement or replace present methods of Nveed control. This publication is a sequel to Hawaii Agricultural Experiment Station Technical Progress Report No. 135 (see Related Litera- ture), _ ture), that describes earlier herbicide studies with tomatoes in ~ Hawaii. These same herbicides were also tested on peppers and 0 5 fl0AQ~49,8 0 ` ,:
Page 195: wrm95d00
50335 2699 ~"TP !"370 Ca i'Oc-t_Caracroes, John W. ~ C-! r~ 1964 AMERZCAH T0MAT0 SEAR,.1?OK; 196~(Ft„`144 pp. Ref C. Stedman MacfarZatzd, Jr. Westfield, t:ew Jersey TP ' 370 .Ca ~ tl 5 0 0 0 02 4 9 8 $
Page 196: wrm95d00
50335 2680 ' ~. -~:: . .. .. .~ . . FOOD SCIENCE AND TECHNOLOGY „ ~~U s anu taeirrrouucts Th e iocnemi5t y ,ot v• . ~« ' ~rces~ ~, ~ j/~~~d` ~ • ' • ` tr! L X ,MAZ ; it ~ .. .OM iYWW Eaited by A. C. HULME - A.R.C Food Research Institute, Norwich, gRg#aed . VOLUME 2 ACADEMIC PRESS London and Ncw York 0 S d 0 0 0 2 4 9 7
Page 197: wrm95d00
50335 270• ! Tr4xislation ~ ~ ! ON THL' F;'FL'CT Q? 'MS00S .~. ~?A.TUP.ES rM .. T9Z ',-f3" STAGE G:' CUMM 7MG~''LA B3I~::Z~` i T03ACC0p fi7 SUlvf o Donadcr.y aud Luciano TomhQSl English traus2ation froans II Tabacco 18, (No. 6501% 211-19 (19-34) oso.ana~4 g93 ~
Page 198: wrm95d00
I "Reprint Giovannozzi, M. RICHERCHE DI FI-SIOLCGIA E DI BICCHIMICA SU NICOTIANA TABACUM VAR. VIRGINIA BRIGNT, by M. Giovannozzi; L. Tombesi; T. CerviFni and R. Verdura. Reprint from: I1 Tabacco jU,1 (No. 627, 630 632, 632) 5-55 (1952). 0 © S o 0 0 02 49 92
Page 199: wrm95d00
i 50335 2702 1 I > 1 ';1112 Shapero, Albert AN EXPLORA':O.tY STUDY OF ^f:u? S:F(iCTFJAL iL:ZD DYNIiMfCS OF M, R & D ZPIJ~JSI'P.Y, by Al.;.art Shapero, Richard P. Rrwe13, ar,d Jasaes R. Tombaugh. Zune 1964 1~4- g. Stanford ReseaY::Fi Institute Menlo Park, Calif. 0 ©so.ooa.2 49 ~1
Page 200: wrm95d00
VEGETABLES--I3I5`EA,SES Aam FEsTS--EorTIbQlL1 -- aLAN1"B--DiSEASPS ~itD ~5151 _ "` _ Aptcnitnre SaeWIooic Yw 23 Ix MeY-C-223-T3 t . .1 Market' Diseases of ZY3C ~`'eppers, ~. ~ and Eggplants .~~ s,r IACT r. KcoscoCe. .ani.• ,&MM gAEOLD T. COOK. lines..+ .,.i* Vh1jAD[ A. 'WRtGii't'. a1 w OwAoiog"4 : :Mask" Q°`tity Ruea.*A Di.i.io. : Agrieltltttrii BeseSrali Ser7~ic0 tJNTi'EI? STATES DEFUiT1MNT OF AGFhCiILTL'RE .v.dd.,Ra., D.C. 1,9" lR aLM 1/ ~Supd0o4mey all~t Od DM=mLY4 II•IL CoewuW" P1'iSL'it OffM ~a... YA01 N fiA" i
Page 201: wrm95d00
50335 2701 United S#.gtea _ --- .._' Foreign hgrioti: tural Servirs3. WORLD Z10pSCCO ANALYSIS. CGNSTTrr.R MkRKETZNue United S~tes L3psr~~~nt o~ ~~;-icul'•:urg= Foreign A5 iau.l.t.ire Report '!,;. lu'1v 1958 23 p, S,ipr+rintEZ:den$ ot Lbc^zmentas U. S,, C,ovL:-n- neut rrint3nS 0ffioe6
Page 202: wrm95d00
50335 2706 ) ~' III Du2-74 : 100 S.P. F~r wr~on. Pln•sicrL INochPnr. (1973). 3, 1-12 „l~4s~-- - . /1'ubJished by Munksgaard. Copcnhagen, Denmark No part may be reproduced by any process without Nritten permission from the author A Method for Determinina the Retention of Inhaled Particles in a Bronchus Department of Emironmer.tal Hygiene, Karotinska lnstitute, Stockholm,Ssticden Received 29 Augnst, ucceptrd jor publication 22 Septenrbcr 1972 A quantitative method to determine the retention of inhaled partiacs in a bronchus Sn experimental animals h:!s bcen dc%elopcd. The method is baicd on free disscction of bruncni:jt sections from formaidehyde-exposed and dricil lungs. The rcgionat retention is cstinrrtcd as the panicte eontcnt a(ter fre-o-disscction compared to the t+: rtic!e content in the w hnlr iune, -l he msrhod has been tested on lungs uf rabbits exposed to 7 prn'"Sc tagged polystyrrne r+urtick,. l hc rLtiuliN show interindividu:tl dii?'crenccs in the rrgronaf drp+.ssition (initial regional rrtentioni and recional retention I hour'afte: e\;-osurc. Tht rcoiunal dct++,iri,)n w2s on cr6'crus'e t",. in rii~ - o-) 0 5 0 00 a z 49 9 5 , .
Page 203: wrm95d00
50335 2711
Page 204: wrm95d00
,,~ ~ ._ .. . r:. rt n o ~R 72`:.^.;9atuiE+ y rt *.~ ;17, "° 1 ii. . .. F:. . ir.i :v, .. r . (~:z ....F:..ir.i:v A.. ;r.r<.'' ,,-` ... R.C:. ,~~ti. _ .... , AA:. JI,~JS~ Y ~j', .'~ z,
Page 205: wrm95d00
d~1Cl~jr. ~U!4iudi+Qiz.Y~IC Q3.r} ~~ OF TOBACp (:~e Rec. '~T". Rec~,o ~ron., E~Z~,tadt~ 9 327? 1-15 (1961) Sdith 3.IR Prepared diCc$t•
Page 206: wrm95d00
~~.. ~ 50335 2709 l RJR CL `SS NO. P XNLpi:LET 72 XII Del ,'t. _ ., .ti. _,...:.. . (L'.nI.versitat Zagreb, I:%~~:itut ?har.--!:olo-ie To::ikolo-l-'e Medizinischen kultat, I:;...~...,. (•.~(3o:.^1' :i:.. i...:~' .~.~...^1 tat, Z . ^:E7, Yu~oslaVia) .::D " ~".TIC ACIDS. t(Spcie_•:i ni'.-_o:inz s aro-.._,~^ t'testn. 17, 39-57 (:.0"'3) (ii: Scr'uo-C-zo::ti..;, with Ger~:.: : su:-rr,3ry) *.;ote date.* ~~J filt .~/tQ ~ l a t+07~ Sr . ilQi?~GV v t? S 0 ~0 n'o 2 4 9 9 8
Page 207: wrm95d00
. .. p . 4 - , -_ - E.1R CLASS 1WO. MICRQFILM No. 199 (Yugoslavian Inst. Tobacco, Yugoslavia) INVESTIGATION OF THE EFFECT OF FERMENTATION PROCESS ON THE QUALITY, TASTE [1ND AgOKA OF ORIENTAL TOBACCO TO OBTAIN INFORMATION FOR USE IN IMPROVING THE QUALITY DF AlEYICAN CIGARETTES. •Yugoslavian Inst. Tobacco, Final Rept., Beograd, Yugoslavia, 83 p.'(1972) (in Euslfsh) *1974, No. 18, St 7635* *d* '~ e Tobacco chemis try:
Page 208: wrm95d00
CIGARETTES--PAPER-SMOKE COMPOSITION/TOBACCO--SMdKEN-COMPOSITION/ 77 I1C Mu TOBACCO-SMOKE-GAS PHASE/ RJR CLASS NO. PAMPHLET 77 IX Mu f, Muramatsu, H.; Mikami, T.; Naito, N.; ~~ (Japan Tobacco Salt Pub. Corp., Cent. Res. Inst., Jap.) A MODEL STUDY ON TIiE DIFFUSION AND THE DILUTION OF LOW MOLECULAR WEIGHT GASEOUS COMPONENTS THROUGH CIGARETTE PAPER DURING S1iOKING. Beitr. Tabakforsch., confidential manuscript, 22 p. (1977) (in English) *Keywordst* carbon monoxide, smoke, constituent; . carbon dioxide, smoke, constituent; hydrogen, smoke, constituent; methane, smoke,_ constituent. 4 e effects of diffusion and dilution on the poncentration of gaseous components have been studied by a model consisted of unlit cigarettes differing in paper porosity and length, 05__00,0 0 2 5002
Page 209: wrm95d00
50335 2?1t t . Sar.a, T;Ztcmu ~ f~., F[~~~ TH." i,.i"~,, a\~!. ~i..V\l:.~U.iw~.7 .~i1 ' .. CL1 Ti..E n.ui..lYn.: i.aioT.i.:+tal~ b',:,.'.__...':'2 i.~!1J.aa.1i. {`wv~1 .+. w.a ~=a~~A~ X~~a~rrt .~~tf~Sa ~uu Kt4=,c'rai ~%u~ts~ ~~~~ ~. p + ,~,~.#. c TL ~~ C } J~.u~.. L ~C}J~.u~..L~~~..u~..L~~~ ~w~+L+:ai i J(7::.~ ~.s ~ :-'~_AC~. ~3Qr• 0 oSQ o n025003
Page 210: wrm95d00
, ~`itrations in roN- ;:quaaus soI*? iw-jons. (Card 2) F~'±t 3 G~?f3at e T.i.".'t'.ys AN 283 i5, ~fS^-;zj (:icr52); 5I6-520 (1953); 521-55 ("I~'t>3)i i 526-530 (Y453)• oso.o0 0_2 5 OpI
Page 211: wrm95d00
Onis_hi. Tr. ;s; 1JVl.o(3TILi, Jr ju"Ii? ji:DIEW FRUSI iiHE '.~:,S.`i= OIL ~~~' ~'., ... - `~~~O .~T_::..~i; ;:. - ~ ,_ .. Y p f~J~ .~::,~~ ~... ~ t.79a5awf! f R'.{i:3"J ~'f'"?4 f,g a~i "'"+-Y~2~~ f,~?„_,_ . •~ ~ - .. .. . . , . Ls Sp!•iT2t frC1!7S r1?`_.LI.s "'ri1Cv C,`:i*I-. . 't^, q:r Z-1 ( j,ro. 1) 57-? 3 t? 9`3 5~
Page 212: wrm95d00
Journai of Neuroscietrce Research 3:327-333 (1478) Q)1-74Etectrophysialoaical, Behaviorat, and .r. Stereospecific Site for Nicotine in Rat Chemical Evidence for a Noncholinergic, C?) L G. Abood, K. Lowy, and H. Booth Center for Brain Research and DePartment of Biochemistry, University of Rochester Medical Center, Rochester, New York ~,(,Z,~- • o ~'-~~~ Pharniacological, cicctrophysiotogical, and bi •Eh.hrmical studi e been con- ducted with rats in an attempt to demonstrate that some of the behavioral effects of nicotine may involve non•.•holinrrgir brain sites. The brtw.ioral rl slwnsr consisrrd of a I+rostration-immobilization syndrome following the injection of 1- 10 pg of nicotine into the region of the latrrat or third trans- mittrrs and their ant•rgonists, and a number of other psychotropic drugs were ineffective in either rnlsnuing or antagonizing the action of nicotine. Associated with the behavioral rrsponsc were distinct circtrophysiotogical Q Q-` ~()Pal2kns4#co*d tmaectrodes implanted in the dorsal hinnucaninus in I
Page 213: wrm95d00
(0 c Off]IIStaI' lEtiEnS, pp. IAS-aAA, 1093. 7sr-z To CAS CHROMATOGRAPHIC BEHAYIOR. OF PERRALOALKANES , 1WAlA, Iad lldshiairo HAR1N Department of Chemistry, Faculty of Science, The University of Tokyo, Hongo, Tokyo The Institute of Physical and Chemical Research, Nako-shi, Saitama boiling point, the estimated volume of molecule and the molar The gaschromatographic behavior of,perhaloalkanes containing one or two carbon atoms and different kinds of halogen atoms in a molecule was investigated. The logarithm of the specific reten- tion volume was correlated well with the halogen composition, the v5oo0o2soob
Page 214: wrm95d00
1}IlI Re -76 RJR CLASS NO. PAMPHLET 73 III Re2-76 s.p ;S:P, 2 Yoshida, D.; ~r ;, (Central Rcs. Inst., Jap. Tobacco Salt Pub. Corp., Kanagawa, Jap.) , - PYROLYTIC FORMATION OF BENZO(a)PYRENE FROM VARIOUS COMPOUNDS. Central Res. Inst., Jap. Tobacco Salt Pub. Corp., report, 26 p. (1976) in English) *Keywords:* benzo(a)pyrene, smoke, constituent; 4 " ' f i d i tuent; ' para ns cure const ,, • f . ~ - 4. . ..~. ' solanesol, cured, constituent;_ - chlorogenic acid, cured, constituent; calcium pectinate cured constituent; , , cured constituent. ^~neophytadiene ;: . : ;-, , , ~ ; .
Page 215: wrm95d00
~ a f~ STUDIES ON TIIE CURING OF TOBACCO LEAVES. Bull. Morioi:a Tobacco Exp. Sta., Jan. 3, 175-198 (1968) English su mmary) *i;eywords : * a-amylase, cured, constituent; 0-amylase, cured, constituent; aspartic, curcd, constituent; catalase, cured, constituent; D-fructose, j-deoxy-y-L-alanino-, cured, constituent; D-fructose, 1-deoxy-1-(y-aninobutyric acid)-, cured, D=fructosc, 1-deo:cy-l-L-prolino-, cured, constituent; invertase, cured, constituent; peroxidase, cured, constituent; 1-Pipecolic acid, cured, constituent; G1y*iefplc0idjsej cured, constituent; • . , . r 50335 2722 RJR CLASS NO. PA.`fPHLET 71 VII To Z
Page 216: wrm95d00
50335 2723 VI On7 L~nfehi, Inso STUUI^S G"v' THE ESSSNTIAL C`ILS 4F TGShCCO ?.^4;r-7cO r. p;.~ R'" "4• { •.Si i~LJ ~`T~"L i(. ~.1 by ~V1 j Y~i \~r : .b ~ Iaao Onighi, Hideo Tomita ets3 Te-L3uo Puktzauni. Reprint Yroma Buli,, , &7. 0 6I-67 (~To, 2119~6. ~ 5 o p c? 0 2 5 0 1, 2
Page 217: wrm95d00
50335 2724 1 `JZ Cn 1 4 On{8htj, T380 S'1"UD37-S C?7 i~~.~r. :'$Sr ;PI'IaL OILS OF TC?AL!:0 n PY.`~. T.T ~^. u~ i~`~ lv~2LyL 1';1b2li;~b~2t LEAVES1I b,= L^:Ci Cia.Slhip A"UFTE.G iiU:1:it~- iBt3%1+? ., r uku•a.c"a. Repri»t -7roms £ull, A„ric. C<tbm. Sace Jepan "'i (ivo, 4) 2:39=242 (1.957) C'? ....,..:~., 0 5 0 0 a 0 2 5 0 1 .; .
Page 218: wrm95d00
50335 2716 November, 19731 wn.t.r:Tm ar 1rn. catspfcAr. scxatcnt or JAPAN, vru., 46, 3''r4fl-3552 (1973) 78 IIi Ku . Oxidation olOCarbon Monoxid over Transition Metal - Ion-Zeotite talysts Toshihiko Kvso, ~-~and Taiseki Kuxuos IJIr/bartqaMN .f S,tafJatic Chrmfstry, NaFxl(y ef FngixarinR, 71, ,Usiurrsity of Ta4yo, /latgo, Baulyo-kx, T.kyo 113 (Rcccivcd January 22, 1973) Acfxnrption nf cr.cyGon arKd oxidatirtn of carbon monoxide was invcstiRaln[ on several X and Y type •r.cotitr., thrir Na' tH•int; tr1t4•icPtl tly traRSfhlrit n7rta} Iqns. Oxygen atL'tftri)tlon K'as ol/scrvCd ofl (.r(I I), (:u(l), and Fc(II) .th, giving an oxygen atrnn to mcta) ion ratio of O.•13-- 0.62 or nearly f).5. iunx whrx,r nxKtxtirtrt 1N3/Mlllalx are hit A xmalt anuxmt ofoxygr•n was aciutrlx.tl un'{'I(1), C.o(tl), and kin(II), a.r cxpcctcd fi•cim their standard oxidation tKttrntiatx. No oxygen was adsortird on Cu(I1) and Ni(II), their valcncca bcing di(licult to incrcarr. 'J7tc activities of thctc tr.ausiticiti mctat ions for oxidation of carbon monoxidc incrcascd cx}wncntially with the increaxc of Ihrir standard oxidatic>at potential. Kinetic studics on CO oxidation over Fc(11)-X and -Y s.cotitcs have been ntade, and a Rideal mechanism is suggested where CO molecules in the gas phase attack the oxygcn atoms dis- sociativcly adsorbed in thc bridged form of rc°}-O=--Fc°}. Thc di(fcrcncc in the activitin of Fc(II)-X and -1' catalysts is 7isctuscd. Sincc xontc transition mctal ion% ~arc casily reduced by hyclrogc•n and hyc}rncarttcinq and rc-oxidizc•cl by oxy;t;cn, ~nsi~}nn~nrt~ ic~ zRlitay sttLtr it~-rc.~{Iy~. active fnr ic d.~ulaNon h~lt(rcx~ GdRt '3om~Ipa~!(trs havc rcccntlyI,ccn pubtisltcct on catalysis by thc transi- Txperimental Calrtlyst Prt/aralrort. The zcolitcs uscd in lhis study were 13X and 13Y type Linde 14iolccular Sieves. Catalysts were pr- parcd by the exchange of sodium ions of the zcoiitt Cr(IlI), Ain(11), Fc(11), -_----------~- . . 0
Page 219: wrm95d00
.:a.p i T1r::•,t7r,~~ V.2 C. ~l...n. V ~..Q .. [~. . ._.__ . C_ ... sCq ~~;00 0 flS0.00 0.2 5 0_14
Page 220: wrm95d00
50335 2692 ai Me T_ C.;l 3- 73 AHI;;E/,+,^ :'? /,1SP,1Ri~C.L'S/BEtkP+S, S."1_-%-D/PI.AC!t.PFR?.?FS/RT.UERERRIF.S J';R('iCCOLI/ BRUSSELS SP.^.UUTS/C.1:VT-,kT,OUPES/CARROTS/CArJLIFLCi'.iER/f:EI,: t'TAC/CET F:RF/ (:Hl?RRIrS/ CALLARDSi C`~=~1, S':'F:ET/CF~~tBERRIES/D~lI~DELIO~S/)AT~.S/EG(;Pt~'.*.'T/s:`tDIVE--rSCAR!)LE/ FIGS/FRUIT AND VEGETA?iLF,-FIL'4 DIaECTORY/r,a+.:'.LIC/rA!3SERF.RRI::S/CR:Vt'E'FTtUTT/KOHv?.ARI/ LE40,NS/ I.ETTLTCT:/LI'!ES/LYCI}EES/'tUSHF.00?tS/'•;UST,1rD GRFENS/OrRA/T'ARSLE`.'/DARS~?I?S/ PEACHES/??:~.•aL2SlpERSL•1:1 MELO\tS/PItTFAPPLES/PLUtilS-a?tUNP.S/PQ`lEGP'~A.'ATES/P.AT1I S.vpS/ RASPBF.RRIrS/SHALLOTS/SPI:3ACH/STRRIIJ8E°.RIES/TAt1GF.LOS/t~?ATER C?Y-SS/'•.'ATER'..ELO~:S/ ` I ~. ,.,, Io •.,,r~ / '•~ 1Ct1LB: CEj/C~^,Ca."7LiS/C'~'CliRf.'.'t:.~iGF.A.~:.S/ ~.QiLE~I ~•'•^T.-CIZ~~,tti'YL ti,:.:i.+.~: .a1..,t~:.at 5 ~'..T..~ _ _ e ~• • i i, ^• ..r v r..,.. . C.I ZivEG ~v?ct+'v.- i 3 ~ .•` ' ~}:5t -• •'^ /:;EC::~rix*:ES/Q"'IC:;: fOR~.::i~a; r,Sj : ~ GP _Irrt"Tui' p"tD ':?'GE:ARLE Fe?CTS AND POI:tiTTE"~/ By UNITED F•.~...SU f:UI'f A, J VLGETASLr ~SSnCIATIi.+:t, f~ ~ c~ 0 n 0 2 4 9 8 1.
Page 221: wrm95d00
Enoki, Yerunnosi QU'3~ITi.TWT ~VE C?UOUL'e ERT?.ATICIT OF SUB- CiQM:~NT; 11; LUT UVI::. -CLOBIN, by Ya811T1a3ri Eo.okf, S:auumzi iomittR --azd Motoyul:i_ Sato. Jetp. Jour. Phyeio1. 16, 71a-Yt3 (b`.~66)
Page 222: wrm95d00
, , Ofi C~.SEO'~IS FEF1';ENTATION Z:i by Yukio Tomf yaeu und Bahti Zaa4tra3 Bull. Jap. Soc. Sci. Pisherita 19 535-8 (1953) ~ 0 5 0 0 n 0 .2 5 0
Page 223: wrm95d00
! QUINOLINES/ Apik 0" awaL. 4 (4), 8b1 N 864,1978 77 II Re-79 Structural Requiri~ments for Mutagenic Activities of S.P. N Hcterocydica.Bases in the Salmonella Test System Takashi MATsvxoro, Daisuke YosKroA, Shigeaobu MczusAta, ~rF and Koichi Kaatnutzu' Gwdd Renarck lwsrfme. Tbe Japerr Teiaaun drd Soft Prbdie CarparrNae, 6-2, Uawxaaka,lNfdorikn, YokaWw. JCmmjawrr 227, JoPaie 'Departmau ojFood Science and TecJiaolrv. Farrdiy ojApkadtare, 1Crnto U,Qfverstty,lCyoto 606. Jopaa . lteceivcd Novamber 28,1977 The mutagptic activities of quinoline, isoqunnofint, pbataeuhriditte, benxo(f)quinoline, beoso(h)quinoliee and their te-amino derivatives Mrt compmaced in relation to the cffoct of peuctursl dffftes using the SaiiuotKOa trpdtimttriurtt test spsoem. AN muta=teie compounds tested require the liver ntiarosomal fraction for ffidr tnuttgeaic activit?. PEknanthridine, two beoxoquinoiines and quinoline were mutagenic. Q-Amiaatiou of two beoaoquinolines and quinotioe resulted to increase their mutagenic activity inoemively. Addition of a benzene rlngto tberbatPene moiety of 2-atnittoqulnoiine, so that two carbon atoms are shared, affected distinctly ffie increase in the mutagtnic activity. The oo-atisleooe of benzoquinoline series with 2-.minobanro(f)quinofine showed the ctear sYnerpstic action. 05o~po0 2 5 0 1 o ..,
Page 224: wrm95d00
STUDZES ON THE PRWiTCTY0t3 OP YEt+ST FR(3M SEAWEEDS. Part 1, 3, by Yukio Tvwxy"u aua nuiYei 4=tLani Jour. Agrtc. Chem. Soc. Japan 25 406-10 (1951-52); 26 6-10 (1952) 0 N V .J 0 • O l/ V Y~ M 0 IPMWW"-",*-.,'
Page 225: wrm95d00
50335 2715 Y=aF,aki s Maeaa RijATl.,f)3ivHjP AoCReMST..a...i ~ CIGARMEalQ TOTAL PIi_TICIILfa1: :r•'MER (}? W= AItD PRISYCAI, PRCPMmES OF CIG.cuTTESo by 4a=aaki, Masao, Seiko Tcsa3mur8 an3 Keiko Mf.Rauhashi. Nippon Senbai Kos&a Chuo Rencpusho Kenkyu 8oko3cu ~~6w (No.106) 277-9 (1964) • English Lrassle.tast ircm Lh q!~3apaneae. m ~J 4 0 S 0- 0 a 0-. 2 S 0
Page 226: wrm95d00
50335 2733 QD ~6~ A rrc~r p~xiad± - ~.al1e of tha es rner.ts ba.edGrt= T the structnro c,f tho eton. Lanrlr.n,, Chapmen & H-a 21, 1954. ~ 32 pa 26 a 30 L'm• . .~ ~.-..-,,....~....~e- ,_ 0 5~ 4 0 0 _2 S 0 2. ~!
Page 227: wrm95d00
50335 2726 AVk. Afol. C/kent, 43 (3), 675- 677, 1979 . INDOLES/ 673 Sbott Conmunication 77 II Re-79 S.P. Synthesis of 2-Amino-9H-pyrido[2, 3-b]indole Isolate l'as a Mutagenic Principle fromr,PyTolytic Products of~rotein Takashi M~ArsutNOTo, Daisuke YOSHIDA, nd Hajime MATSUSHITA Ceatra! Researck Institute. ?Xe Japan Tobacco aad Salt Pub(fc Corporation. 6-2 ilnwsaoka, AJidvrf,lry, Yokolm.na, xawww»a m Reoeivcd December 25, 1978 We previously demonstrated that the pyroly- zate of amino acids and proteins exhibited high mutagenic activity,`•" and recently we methylpyridine according to the method of Takahashi et a1.; ' 4.20 g of anhydrous potas- sium carbonate, 0. 15 g of copper powder and 3.30 g of o-phenylenediamine was heated at 170°C for 45 min. The reaction mixture was cooled and extracted with water and ether. A small amount of decomposition product was filtered, and without isolation the compound 11 in the aqueous solution was converted by the treatment of nitrous acid into the correspond- ing benzotriazolylpicolinic acid (I11) which was recrystallized from ethanol to give 1.421 g of crystals in '9% yield; mp 262`C, 10 S m/e: 240 (M*), PMR azYn°'°': 7.50-7.83 (2H, m), 8.11 -8.50 (4H, m) and 8.78 (111, d, J= 8.3 Hz), and CMR o=yso'a': 115.1 (d), 117.0 (d), 120.0 (d), 123.7 (d), 125.6 (d), 129.5 (d), 131.0 (s), 141.2 (d), 146.2 (s), 147.4 (s), 150.6 (s) and 165.6 (s). In the CM R spectrum of 111, singlets 0 ~'J 0.0 00 2 5 0 1 5
Page 228: wrm95d00
50335 2731 Horiu•.hi, T4d&a 07 BACTERZi~ I.y i] ~+-h CA: cw:•'= . - ", Pe~Or~RTIES 3 ^L t t~}~ ~%'..~~kCT7~ I- , L [s ~..ri't rJ ~ «r OF ~ ., ~d Aa~ on ;.t*~r=~c:hi, .~zon-ichi ~cF~~zawa ~> :- Tw Jil z Bicchii. r~arhY3. Acta 55, 3~52-53 (1962) 5 ~ ~ n 0 2 50? Q 0
Page 229: wrm95d00
I Wi-80 S.P. N(1RTH CA.'tnL1!qkL--'1YSSE'tTATIf1NS/ ~ A DISSEEtTAT'tQN Ci!]JIJOGRA~s~'-HY (UP11VZrSltv ~~- MtCre.-IlIYtS tnternation.-Il 0 s 0- 0 0 - 0 A 5 02__s-_ ..
Page 230: wrm95d00
73"X $# TOBACCO--SM4KING--PSYCH4LOGY/SMOKING HABITS--RELINQUISHING/ RJR CLASS NO. PA.`THLET 73 XI* Ikard, F. F.' (Aaerican Health Found., N. Y., N. Y., U.S.; Rutgers Univ., New Bruns•rick, N. J., U.S.) TUE E.YPERIEaCE OF AFFECT AS A D£TEMINANT OF SwOiCI' NG BEHAVIOR. A SERIES OF VALIDITY STUDIES. ' Jour. Abnormal Psychol. 81 (No. 2) 172-81 (1973) - ia English .*1973, No. 11'. W 4848* * j t* Tobacco analysis (medicine):
Page 231: wrm95d00
.,. y~ s...... . ~ c taG7 CTL^?TrS ON 71111.1 i^:3?'UC'.i'TGN 017 rf?L~D Vtwl :,Z;wuZD. `r'arc. i. e;sti,0da or ~reagratiou of Yrsaat fircvn Sez-~r:id, by Yu kio To.dyauu s:zd tfcthei ::: kl L?ni ;;'aar. "^ric. Chm. Soc. 3ap. 25 479-83 (195Z-- © s o 0 0 02 s v 1 8 ~
Page 232: wrm95d00
E z QSZOVavsa •3 •ff 'uoI2u;RRVM salaMW0 ja •3daa ^, ',r-, Ra2v; 6CT [.• -. .,~., .. .a tY i.l~...v... •~ '`2 •~ 31R?. ZII?.7QT •~ •~ ~tt~ trst~rstp.rro-.rcw • - . . -. • . 'Y.LYQ A.l.1SSl Ja CJ1t1 Q31t'V tAI1S:Il:Q 'IY3I?1M2'I3 't Mv11ZOd *SS'YVS tMZ'IJiK •r •f) 4LL3t~L' k .~..~,,.-...,..r.-- ._-7-_. . OE LZ SE£ 0S
Page 233: wrm95d00
.W (1970) Cvi PEit (YI) ~'ri0:7IA C(l.i'LERES, by B. J. k--::r°::cy stnc A. A. G. Tc:aliAsnn. Cuoruii:&ciun MiGmiri:ry neviewta j ~i o. ij 1-43 (Apr. 1970) T
Page 234: wrm95d00
~..._.. W .. . f ~ R1R CLASS '9tf. P~~'HLET 72 VI To .. 7" i~1c•'2, S. - ~ • # (Connecticut AQr. FYp. Sta., New Haven, Conn., tl. S.) i THE Cr1PACITY OF Li'nF F.?ZTRACTS OF TOi3ACfX1 TO REACT WITH OZONE. ; Pnyt6n::thology 6.1. (No. 8) 914 (1971) (in English) 4 4 ~ t ~ *1972, No. 18, t,' ; 95g* *lrr,* >-.---~-- ~c' !: ~r t_~1 *^{~tl' , 0S 0 0- 0 02 5 0 2 6
Page 235: wrm95d00
50335 2742 Gundry, P. H. KINETICS OF SORPTION ©F lI'JItOGM MU CM0N 440Ni0XIDE BY IRON AND NICKEL FIL4S, by P. a. Guttdry and F. C. Tompkins Cb.eaisorptian, Proc. Syzap. Kee.le 1956, L52-b1 (1956) --e
Page 236: wrm95d00
50335 2732 ~~. ' BiocxtaUrr- ET siorx=u,A ^Crs 5 ~ /~r~_ aG3 ~~9G~-.~ • . ~ , - 7Z ~~ RG, - ~a~'s, f~~t,~ G - • . ~ . >~ ~ " ~•'~: . RATES; OF B-A-LACTOSID.ASE S~~N~'HESIS . . •~: . _ • . .. . • • , • TADAO HORIUCHI', AND AARON NOVICE ass• :' . . :. . - .-. . . - : IV ISOLATION AND PROPERTIES OF BACTERIA CAPABLE OF HIGH , 1"i1xts of Mckrirlar Biology. 17sivcnity of Oratm Extsw, Oreg. (U.S.d.)" (Neceived May 24th, sg6t) .: SUMMARY " • . . .' A procedure is described for the isolation of bacteria able to make unusually large quantities of fligaIactosidare. A number of such hyper strains, as they are called, have been isolated and some have been found to make protein containing as much as 2.5% flga}actosidase. This enzyme in these strains "appears to be identical with that in normal strains with respect to Michielis constant, heat sensitivity, sedimentation - ' " • •. w~i. ••• . .- __.- _ _ A ~__ _a_ o s 0 0 0 02 5 0 2 1
Page 237: wrm95d00
50335 Z7+11 ~...,...~._~~... Ja~..ra.~.:.rl:....eJi..~..~...w.......a x Sa 6 Rashev, t+i. CLINICAZ. INVESTIGATIONS WITH T'r'i NICOT1RE-FREE CIGtu"1L•'TTES ATRaT3.BAC by Y. Rashev. B. Zcgrafski, and I. Tomov (uigher Medical Inst:.tiute, Sofia, Bulgaria) Nauc?:. Trudy Vissh. Med. SofxR 43 1-10 (1964) - in English
Page 238: wrm95d00
XI COI -80 RJR CLASS -no. P1i1HNII.ET Xi Coj-80 s. V. S. P. Peterson, James R. v(R. J. Reynolds Industries Inc. Winston-Sa1e., N. C.) ` USA Today'l980 p. 29-30 (March, 1980) (in English) *Hote author and affiliation* "in the face of today's challenges, which seem Impossible to surmount and to comprehend, many people within our society are turning to what is good for fhemselves."'
Page 239: wrm95d00
• Proceedings of the Sixth InterntionaI ~Congress on atatysis '~ 40LUltE 1 & 2 ~ lmRerial College, London, 12-16 July, 1976 Edited by G. C. Bond Professor of Industrial Chemistry, Brunel University P. B. Wells Reader in Physical Chemistry, University of Hull Professor of Physical Chemisty, Imperial ColleQe 2 S 0 114hemicat Society Burlington House, London, W1 V OBN
Page 240: wrm95d00
50335 2745 ~ POLAFi0G1~HIC CI-i~ACPE.LATIOI~ OF ~tICGTIi,IC ACID luM `~ ~tt~~ATID C01`'~CU'+~ • II V., by Paul C. Tompkins and Carl IIcb~atity of California Berkeley, Calif., P'ress, 34 p. 23 rm• (Univerlity of California Pub7.ica ~ions in Physiology. ) 0 .~..R.•..,.-..-..._..T.,. : -~.«,...-y-~ •---- O5 Oa~O~S0 3 4
Page 241: wrm95d00
50 335 2748 NITI':OGEN MiPOIINLSS , IivORGATiIC/NTTRD1GE1~ `i;Olfi,~IS(P.IDS, DRGANIC/ Ah1MUNIA/ NITROGEN COMPOUNDS--SYNTHES~; S j A,'~fINES /APtIDES / I~(IDES / IMINES /NITRI LES / NITROGEN OXIDES/NITRIC ACID/LACTA~MS/NITROSO COMPOtJNDS/ QD 181 Ma 1973 13% A S I C NITRKU ~5~iN C 0 M P 0 u 1~D S Chemistry, Technology and Applications by CLAUDIUS MATASA ....,..:-.~,- and Traaslaied from Romanian by SERGIU MARCUS i I o s o Q o 0 2 9 03 7
Page 242: wrm95d00
50335 2111 , I III Du2-7b : S.P, - I 4 I ,, 0 1 i I .a)ko' NO k,'1Ovjx-L -)fQA 6`1-C S~ ( 9' 8 1 I Iv n. .. . . n,tidC. *~-arl 44J5,110 t.a/l 6v.LI. ~. ft 10S721n Radiation and photochemratry ot c4loroflnora T oearboas. Tnn ina~a, Ta : cn~ (Univ. Tokyq Tok~VO, Japan). i Ke1loJeu Na .ct _ fs}, G&1-8 (Japanl. 1'he order of i tn rupture orcRoroduor"'ocarbons was.leiven as C-Cl > > C-F bp analysis of radiolysis products. Similar rnulu w.n oEtdd from the distribution ot producu in hot-atom i s.setiorn betvrecn CF:f1•CFrCI and u9r iormed by the reaction 1 o[ "Sr(a, yW~Rr(f.T.)rj8r. These resuiu were compared with tM photochem. daum and the photolysis of ch[orutIunrocsrhons, (I L t011ow.d b~ ytite~ reactions with ozone tuiytinated in the strataapher.. wrs tarid~red oa the b.sis of the ci+emL of surroundings. ~ . ~ ( r per:hloroAuqroalkanes) {t {tT~'.j{;. C-C, C-F, C-Cl ta EAQ(7)MN* 0 5 0 0 0 02 5 0 0 I :& is TIT t3t L~a)F3• Kaaan~"tan C~rnr. ~~P~ttS}~ 1,1,2-F 1 ~ ts a F~ 7•~Y~' ss s$ Y(CFCI.•CF2C1) ~tyi$~ Ca T Llhf'c#`?k ;V A ! R 4 F'l'1,9 7-Cf}t T i,T-,2! ! 0 7
Page 243: wrm95d00
TOBACCO INSTITUTE, INC. /TOBACCC--St4aKING--PASSIVE/TOBACCO--SP{0?ZING--PSYCHOLOGti'/ SNYDER, TOM/BANZHAF, JOHN/KLOEPFER, WILLIAM./- DR.AVIADO/TAMERIN, JOHN/ 74 X Na RJR CLASS NO. PAMPHLET 74h'tia Nationa2 Broadcasting Company and Tom Snyder National Broadcasting Co., -Tape, July 2, 1974 (in English) smoke with John Banzhaf III of ASH, William Kloepfer of the Tobacco Institute, Dr. Aviado, University of Pennyslvania, and John Tamerin of the Silver Hill Foundation. Includes discussion dealing mostly with passive smoking and why people *1974, No. 13, W 4497* *d* Tobacco medicinc: _..,_,,...,,_.. r 0 500 00'2_5 039
Page 244: wrm95d00
lluiry :oc3.,.)Ly Znterrxatioral `I`GiL~3 ilL.: ~FI:: ::i.ia' r::W IiG;7 CU IT (Dairy 6acielf;y In:.c:rzuit.:IorNll Publ.3.t;ntion i:v. :~2 ) 1- 'G7 21 pp. Ik iry SoCie4;~ Intc,rII. Wat3iyir~,torr= 's). C. o s o.o t~ o:~ S 0 3 8
Page 245: wrm95d00
i fi G• Clare, G. ~Le g s •s R. J•; Can.) on t O L , ., ~a y Gue1 h 50335 2752 Guelph, Dep. Psychol. , P + E COMPONENTS OF CHOICE i- (~ . ~CO ON TN NCE OF COSOL ANDTOB THE INFLUE i~ 4- REACTION TIME. in English) Jour. Studies Alcohol 36 (No. 5) 587-96 (1975) ( I i os0 ©n 0 2 5 0 4 1
Page 246: wrm95d00
II To (1965) A BIO-ASSAY FOR THE CQtICOMITA.~?T ASSESSHENT OF TtiE ANTIPttLOGISTIC AND THYriOLYTZC ACTIVITIES OF TOPICALLY APPLIED CORTICOIDS, by George Tonelli; L. Thibault and I. Ringler Endocrinology 77 (No. 4) 625-34 (1965) a 5 0 0 n 02 5 0 3 9
Page 247: wrm95d00
50335 2753 -nn 155 To '?'IM IZ,H A?1 Ci,::~i~'"~*'~"'0, t'F HT:Ii PP M'IZZ v^=, -4:~'t:+ r-Wi1°. ci4- edo 1959 :Ixs,:aa sr.d I-TaU ,. ~~.,...,~:.~..~.~,...a.w.-, o~aac~o~5o4 2
Page 248: wrm95d00
50335 2751 . TOBACCO--ALCOHOL--RELATIONSHIP/TOBACCO--SMOKING---PHYSIOLOGICAL 77 x Perceptual Motor Skills, 43, 899-903 (1976) (in English) Leigh, G.; *"~ - (Univ. Guelph, Guelph, Ont., Can.) EFFECTS OF ETHANOL AND TOBACCO ON THE JUDGMENT. Le5 RJR CLASS NO. PAMPHLET 77 X Le5 --To determine the t:ffccts of the joint aJministration of tobacco lut~1 cthattol~on shorc-intcrval time productittn and to scarch for diffcrcncrs be- twcen the awerttling, the i,rak and the dcsccnding limb of the blood alcohol • I cune, two gmuin of 6 matc subjccts.vcrc tested on intctvats of 1.3, 4.0 and 9.0 ,sec. Ethanol at O.OG -q atul 0.08$'u bl.nxl alcoh+>A significantly lcn$tlxnctd tlte ~scotcs arxd one cigarcttc prusiuct.~J lovcr scores. Thc rclatiunship bctwccn kvcl iof blood alcohol and time scores rcvcrscJ in thc latter part of tle tcst session. ;Thc results arc d;scussctit in terms of effects of drugs on artntsal systctns. .., ~ ----------T--- I- o s 0 0 a o 2-5 o`4 o I I
Page 249: wrm95d00
t gig-L{OGRAPHlC DATA SHE ET T.-r-ak and Satft K /e 9~Personal Nfj2 Sampler System Demonstration 7. Aabm(s) . and Gerald M. Freedland i. Performiag Ouganizatioa Name and Address Walden Division of Abcor, Inc. 850 Main Street Wilmington, MA 01887 1L Spoasoriaj Agency Name and Addtess Of f ice of Assistant Director-Mining Bureau of Mines - U.S. Department of the Interior Washington, DC 20241 S. Repon: Date -February 1976 6. Perfocmias Organizati t. Performina Orsaaizati No. 10. Pcojecc/Task/Wor(c 11. CosKractftq¢ No. J0155190 13. Type of Reporc & Per Covered Contrac research, FY 19 14. Spoasoriaa Agency Cc 15. SupPleweacarr Notes Approved for release by Director, Bureau of Mines, April 6, 1977. 16. Abstrsccs A complete service system was established for monitorin g personal expos ~ ~p t e qas~ve~do3Lmetry. This system is structured such t a~idimMd e~o~ i~r~u~ed of the user. Manufacturing, analysis, reporting, a recordkeeping functions are provided by the service organization. A field eval," _ ~
Page 250: wrm95d00
50335 2759 , Europ. Phvsiorath, Resp. 13(1)137-44(1977) EFFETS DU BIOXYDE D'AZOTE SUR LES MACROPHAGES ALVP-OLAIRES EN SURVIE EN PHASE GAZEUSE. Un nouveau modele experimental pour f'etude in vitro de ta cytotoxicite des gaz nocifs EFFECTS OF NITROGEN DIOXIDE ON ALVEOLAR MACROPHAGES SURVIVING IN THE GAS PHASE. A new experimental model for the study of in vitro cytotoxicity of toxic gases (0.1. 1 and 2 ppm) for 30 minutes. Thc exposed cells showed morphological chargcs, a decrcasc in bactcricidai activity and a reduction of the nTt' content. The severity 'oI thesc changes is related to NQ: concentration. This new cxpcrimcntai model offers nc.v Tossibi- litics for studies on lhc cytotoxicityof gases. + C. Voisin', C. Aerts', E. Jakubczak ", J.L. Houdret avec 1a collaboration technique de C. Merdy, P. Marquillies et P. Secretin ABSTRACT Alveolar macrophages surviving in the gas phase were exposed to concentrations cf NO: Adenosine triphosphate; alveolar niacrophages; atntospheric ' polltttarrts; bactericiclal activity ; cell cttlttire in the gas phase ; c),toto.ricity of gases ; nitrogen dio.ride. 05 o o n 0 2 s 0 4 8 Bull. i VI Re9 77 , S.P. 4
Page 251: wrm95d00
`" ~T 44 1 #, D.48-r50, 197Q) -7.2.07.j.": i~, !~' V T 3-Atkyl-2-cyclopenten-2-ot-l-one a3utA Rtdt:IZI~. 91"*TLY3, ±irlty'k. REZ& (~c&~t~Tt~f t~fF3t~~;ir i ~#} ifR P 44sF 8q 13 R it 32 I Syntheses of Cyclotene and Its Related Compounds Syntheses of 3-Alkyl-2-cyclopenten-2-ol-3-one B31„4 -- M Itsuo ICItIbfOTO, Hiroo UEDA and Ckuji TAY'SUMt Dsparlscsul~of AgricuUural Chemistry. College of Agriculture. !1. ~ ~ „~ n n J qUniversity of Osaka Prefccturt, Sakai ~ ~ (J tJ ~ 6 V V An exeeiknt synthetic method of cyclotene homologue hae been established. Reaction and ethyl acry!.:te in the p^escnce of sodium hydride gave
Page 252: wrm95d00
50335 2757 INFORMATION STORAGE AND RETRIEVAL SYSTENS---CONGRESSES/ ... PROCEEDINGS OP THE z INFORMATION RETRIEVAL . Fourth Annual N~ational~olloquium 699 967?~ THE USER'S VIEWPOINT On Information Retrieval 1 AN AID TO DESIGN ~...~«..~ . 1i~. Rat~ w t.c t e`~`•e. a fl~.a..~ ~ A.uk..vDo~ ew.eaa f..io. T1u M.ue SeAod et Elstric.l g%;,u,;.X ti.i'a"r M Mu.yl.aai. Wild leas Mry. Fr..YloA Aen.A GwNt* Mrhirry Aw%joei.. far May 3-4. 1967 Plalsdelphia. Pennsylvania E&W . CTIt ~renr+arr ~~to...riw t.a.0.ea.i ~ ftawopbs. I
Page 253: wrm95d00
50335 2754 OLFACTION/ 0E84 !4.#dSa P 1730 - MV J• ~ .0 ' .......M a . . .t OENT RES i0 ~10~ ~ IQ~I1 .~: - ~. 82 V Hy ..~~.~ ._.~: { A.I. HYDE, Rt. FELLER, and Llt. SHARON I A Dmlil Sawoe YstaaRr Adiwlafurrttoa HoWW , Lasa Lkmdr, CaVani. 91337 and Sdrooi ojDentir- aY . Loatr Llni OMdrwalty, Low Lbats. Callfadr 92350 •bwPr kwoMw wtp[ qv wOWj dwNfteS As yowis .duit wd old arbraKS 4*tMd tate dlrtme- Alo* drea*dw °brt iect aats i.mstry seaft ta ayeno.rc, 1VsQ dvic .ei4 wd e0Peivr. Qaie .dd AWl ~md a~ Adurl m f x4mAgondy lar i.mar bn tIK dder arb}seat fX$.eaary deara afae iMaMaide Jor D7rame hwpmmd wody 0~' 0 08 _ I DmK Rss QapO):173b1734, Oetoba 1981 _~ql _, swa eomplettd by each subject. Subjects wmmce instructed not to amoke or ingest any- thing besides water for one h befor testing. Tate perceptiors - For each subject, fivc aadomt mere hdd at a standard time of day in the following order: orientation, two control trials, tongue brushing alone, and tongue 6rtshiai with a commercial denti- frioe.s This sequence ensured that subjects
Page 254: wrm95d00
50335 2767 REF Q 123 Si 1972 Eric N. Simons I DICTIONARY MACHINING ENGINEERINC/MECHANICAL E!dGINEERING--low , r PHILOSOPHICAL LIBRARY I1EW YORIi 0 5 0 0 t] 0 ;Z 5 0 5 6
Page 255: wrm95d00
74 11 As SEEDS /GEPMNATItl'~i/ 50335 2763 PHYSIOLOGICAL PROBLEMS INVOLVED by - .+ftr.w.'4t --' ray sfotogest, Dirisioa of Fruit and Vegetable Crops m.:d Diseases, 1941 . Bureau of Piont lndustry, IN SEED DORMANCY UWed States Department of Agriculture, Bel!svitle, A4d. _ Cootnlation~to the Handbook on Seed Testing, prepared by ~ 116 Association of Official Seed Analysts. .2 ~ &7.rt./ r 4
Page 256: wrm95d00
r A.eJLaef 8b1;' vo1.0, pp.17-33, 1964. p.nnmoa Press Ltd. Printed In C3t. BrR.(a. v - 7 ' Research and Developmeni Department, Colgate-Palmolive Company, New Brunswick, New Jersey, U.S.A. Summary-instrumcntal assays of odoriferous volatilcs from saliva and breath were made' to confirm the prescnce of sulphu~qv~ou,n which wene found to be the offending substances in earlier chemical tusts; and-io establish whether these same compounds were associated with mouth odour. By using the mass spectrometer, such odorifcrous romponcnts as hydrogen sulphide, methyl mcrcaptan and methyl disulphidc were found in the volatiles from putrid saliva but no volatile amines were detectcd in these samples. It was found that quantitative determinations of odour eould be made by utilizing a spccific instrument dcsigned to measure oxidizable sulphur components. According to these mcasurements, the majority of the odouri- ferot~ volatilcs from putrcfcd saliva were mercaptans with lesser amounts of hydrogen sulphide also being present. Experimental cvidencc indicated that anaerobic conditions enhattce the rate of formation of odoriferous volatila:s in putrcfying saliva. '~'he application of these instrumental techniq•us to the identification of com- pounds from the mouth was difficult. Only the mass spectrometer permitted a qualitative identification of the sulphur components emanating from the mouth. . ! ' HE ~APPLICATION OF INSTRUMENTAL TECHNIQUE ~OR THE EVALUATION OF ODORIFEROUS a VOLATILES FROM SALIVA AND BREATH ~ . . ~ V. J. Rtctrtt:lt and •
Page 257: wrm95d00
! a=roRr No. EPA-450/3-74 Q49 AUTOMOB LE EXHAUSE ~GAS/ TITLS.~nOSU6T1 tE arbon Monoxide MeasurFwents in the Vicinity of FC Sports.Stadiums P. r-UT»OAIi! Bach, W.D., B.H. Criss.ran, C E. Decker,, J.W. Minear, P.P. Rasberry and . TSP.fORMING OR^•AN-ZAY'ION NAtJE ANO AO,RESS Research Triangle Institute Research Triangle Pdrk N.C. 27711 ~, REC't'ENTS ACCE3S7oP~M0. r REPORT QATE July 1973 S. -El1fORfA1NG ORGANIZATION COOE ~L PERfORMtNG ORGANiZAT10N REPORT N( , IQ PRC.('.iIAM EIEMENT NO. 2AC 129 t . N a ~r AMii Mfli 13. SPON50RING AGENCY NAME AND ApORESS 1~. TYPE Of REPORT AND PERIOD COVEREi U.S. Environmental Protection Agency final June-July 1973 Office of Air Quality Planning and Standards 14.s-oNSORING AGeNCr coa4 Monitoring and Data Analysis Division Research Triangle Park, N.C. 27711 .Monitoring studies of ambient CO concentrations in the vicinity of major league baseball stadiums in Pittsburgh and Atlanta were conducted for approximately I week in each location. Wind speed and direction were also recorded on the site. Traffic was monitored for 1-hour.periods before and after games.. Grab samples of CO were also obtained during the one hour periods before and after games. No violations of the 1-hour National Ambient Air Quality Standard for CO were observed. Highest concentration occurred i=ediately after.tha games. Traffic was observed to clear out within about 30 minutes after a game. Some of the data suggest that a less effo:ie~'t ~st t f" c+~ t ps~a y esult in violations of the 1-hour National Ambi ent- Ai r Qu~i to ~ St nd~ tf~ c~i~taRrn ~cati ons.
Page 258: wrm95d00
50335 2761 .fnL .rW eRol. voW. M39-43, 19K MWinow Ress Ltd. trleftd I. Gf_ 8.:.,a., 7o/-;q7Re' ,/6EVALUATION •OF VOLATILE ODORIFEROUS . SP. COMPONENTS OF SALIVA 0 Research and Development Department, Colgate-Palmolive Company, New Brunswick, New Jersey, U.S.A. 0 5 0 0 0 0 2 S 0 5 0 Smumsry The objectives of this investigation are to elucidate chemical reactions involved in odour production, to characterize the odour components, and to establish suitable chemical methods for the determination of odour intensity of saliva. It is felt that the knowledge gained from this study will contribute to a better understanding of the fundamental problems of mouth odour. A relationship has been found between the odour intensity and the volatile '. reducing substances (VRS) content of putrefied saliva. Fractionation of the VRS indicates that the odour components are primarily of acidic nature. Substrate and enzyme inhibition studies identified the malodourous ccmposition as being volatile sulphur-containing compounds such as H_S and mercaptans: Substrates (cysteine, reduced glutathione, peptones) which possess free sulphhydryl groups were found to be the most immediate sources of odour. Other sulphur-containing substrates as methionine, cystine. and OXld17ed C+111tAt16inn^ 71en
Page 259: wrm95d00
Finley, T. N. FI7L:•i.7iiATf SU~ FACE TENSION IN F.XPEZi:iENTAL 1:T: i1:CT1:°.'.S, by T. N. Finley, W. 11. Tooley, E. ff. Swe:;Aon, R. E. Gardner, and J. A. Clements. Ars. Rev. RQspirst. Diseases S9,, 372-37a (1S(A) ~
Page 260: wrm95d00
5fl33S 2'i60 SMORING HABITS---RELINQUISSIllS/ TOBACto--SMaI1w-~-lsycHOLOGY/ , . .;. Pratt, S. 1.00,17 5 AN EXPERIMENTAL PROCEDURE FOR THE EXTINCTION OF.SMOKING BEHAVIOR. RJR CLASS N0. PAMPHLET 79 X Ba l (Wichita St. Univ., Kans., Jacksonville St. Hosp.,. Jacksonville, I11.;U.S. Psychol. Record 17, 209-218 (1967) (in English) : • - --- - -- Past aiul present nirthuds of smolung abatement :ue cavalicrly review•rd and found to bc lacking. Three new strategies of be- havior modiBcation-cvntr:,et management, convert sensitization, and contingency management-are described in their successful ~ application to a statistic~lly unimpressi.e sample (N = 2). t Suggcstions are offered for systematic research on the problem ~ of smoking control and the broader implications of these strategies ~ for the field of behavior modi6cation are discussed,
Page 261: wrm95d00
, . - . . • 50335 2762 sIIITte-74 (S.p. 9 Jour. Amer. Vet. *ted. Assoc. 160 1522-6 (1972) ~ r i. Material and Methods 1969-1970 Study..-The Br was synthe sized as previously described' Seven Here. ford steers weighing 96 to 171 kg. v:erF housed at night in an unheated barn ai Madison, Wis. During the day, they were turned outdoors. Hair was clipped from the tail switch to make observation easier. Starting 8 days before and continuin; throughout the study, the steers were i,-~d a ration cons;sting solely of nontoxic, free tall fescue hay, Ky„1 variety.• `£'r2at- . n ~.,,,. mertt of 6 ol th.e sfpe.rs cUns!sted o; Toxic Effects of a- Butenoiide 111ycotoxin and of Fusai•ium tricinctum Cultures in Cattle h.D.; S. G. Yates, M.S.; J. J. Ellis, Ph.D.; M. D. Grove, Ph.D.; R. E. Nichols, D.V.16i., Ph.D. loss of weight, lameness in hindlirnbs, and gangrene of feet and tail.1- Based on our observations, necrosis of the tail may be more prqvalent (but less serious) than THE UBIQUITY OF toxigenic Fusarium molds in tall fescue (Festuca arundin- acea Schreb.) pasture and the seasonal appearance of "fescue foot" in cattle graz- ing tall fescue led to the hypothesis that the two w ere causally connected.3•5•6 The fescue foot syndrome is characterized by Of 57 cattle on a ecrosis of the hoofs
Page 262: wrm95d00
5Q33S 2768 ... . ._ :. . , , ~ k _ ~er searchin~ trae c!:snical Micro- Levin, P. film Tools and methods for searching the chemic3l ~ No.' literature: A selected bibliographJ. 33 Master thesis - Drexel Institute of Technolog7. 1955 . 41 pages. -- -~n-~--~--~- ----- . -~ , 0 500 n o25 0-57
Page 263: wrm95d00
50335 2766 ~ ~.~ i..jL._.. ., . ~ /~'~, l ' • 4 -+~ ,l .'s "//", ~ , ~ MAcHIN RY's . fANDBOOK ; r 1.23 09~- /y7/ I A Reference Book for the 11 fechanical Engineer, D3raftsntan?and Macliinist By ERIK OBERG and FRATvKLiN D. JO:vES HOLBROOK L. HoRTO:v, Editor PAUL B. SCHUBERT, Associate Editor GRAHAM GARRATT, Associate Eili*tor NINETEENTH EDITION, Second Printing, 1971 INDUSTRIAL PRESS, INC. 200 Madison Ave., New York, N.Y. 10016 MACHINERY PUBLIS'iING CO. Brighton, Englar.d
Page 264: wrm95d00
llscbr. Chs. Tech. Lsb. 26(6)357-62t19782 (,traas2stad by 6.g. ) III De2-78 CZWSY'a! OP TSE AZ~ CCSEhIE I11 D.Bt /l2NDSPffAXEI S.T. D! HEIEBAID Zffi.IxtA. Abstrscts of papers presented at the 77th AasErsl YbetisE of the Gersaa 3umsm Society o! PU1sie=l. Chdistrf in Eonstsnr, MaT 4-6, 1978 ~~ The following authors cootribnted; C.E.JOi1GE D.H. T': 3KF- ®IM II.IPl~. /'InC~tTGA?~ SLffiflt/ S 1 ELAI ~{ 0 irc . . 8 T SCSI~T CE~ ,/ EDRTE~ - i. . ' S. A. ~ = ~ ' A~ . ~ IEMIQ1,/ ZETLSCS , ~/ TEOE ZELLNBxI $~ttorisnn ~I'LEl ~~ ~~~. SIEVEET~j ~ N GEOIOGII/PEICBL/ E fdEISE/B DE /LEZQAER / STAIIl~ . . . l BOE L . J~_ --- - ~rE~rs~C/roE~rzi./
Page 265: wrm95d00
50335 2775 RJR CLASS NO. TEXTBOOK TS 1449 Ba 1976 Backer,S.;Tesoro,G. C. LY.;Moussa,N. A.; TEXTILE FABRIC FLAMMABILITY. Since our company is a nenber of the Industrial Liaison ProqraM, we are entitled to a 40X discount. MIT Press.Canbridqe, MA..7b. ISN = 5096 0 S 0 0 0 0 2 5 0 6 4
Page 266: wrm95d00
"OUT CAID" The following document(s) have been removed from the D iior]cing Copy E~Archive.Copy ~ Original ~ otLer ao: Ao. (If Applicable) Do~ynt pa e ltange _ 0 `~' C~o~ Date-~re# Remoqing Party Dept. _ _ !:- Reason (tiOTE: Reproduce on GREEN paper)
Page 267: wrm95d00
50335 2776 OroPnic solvent S, v.7. QD Weissberger, Arnold, 1898- ed. 453 Technique of organic chemistry. tNew York, Interscience W Publishers,1945- - - ?I v. in `i illus. 24 cm. Half title. Includes bibliographies. CONTENTS.-w. 11 Physical methods of organic chemistry. 2 v.- v. 2. CIItalytic, photOcheIIlical and elCctrolytic reactions. 1. Chemistry, Organic. QD4S3.W3u ~~ 541.3 45--8533 Library of Congress E6ur4907, 5 fl 5 0 0 0 02 5 06
Page 268: wrm95d00
. ' NASA `T'rchnic~arl Papcr 1363 ii meh-w The NASA-Ames Research Center S.P. _ . Stratospherip Aerosol Modd HAQMM P-00=40 11. ScnSitlY ity Studics and "i° Spaft "ft"'sU'kM' sc.meft «raToawer _ Comparison With Observations Wn an ON= N ~~ . Aares Rcmtn6 Ceuhr, .Uo~'ctt Fiedd. Grlifonvir ~ rOiCo R. p. t! & D Ass.dktem. Ai.tri" del Re7. Grli fwwiw .0 . io ~ p-~ ~ P. Hsiaiit Ames PeRwricb GS.Kiang. . . y~, 1VtJs+va1 Ceatsr Jor atwsspbrric Keswrrk B.,rlde.r, Co&-L44 ~ ¢* ~~~~~u~, F~~ AfAiw v
Page 269: wrm95d00
$t V C12 50335 2755 MlQ•ari. yot.;12. 0o.3 00.299-300. 1991 Pria sa[ in. David L. C13tit Departmont of Bdolacv Cerftral MdAwn Uiivaraity It. Pleasarst, lBaMw 0159 MS role of the enslee tong= In ct~emoswAsstim bss lag been established and its Uportance In Pxvftta9. xvwz~!-wtive and aggressive behaviars has been well docuoented. Howevrr, tbe esact aechrdam of Lransfer of anaimr:sentai ch®i.cal irifonoetion to Jaoolm's (vasImnasal) orWm has not been aAstantiited. Rhe literature speculates t!At the taqW itself selaes the tmnsfer tlroagh the inaertion of the tcroue tips into the 3nterna3 ljven of the voinaronassl orgoa. Aeirad anterior pcnaesses in the floor of the rat arzlx's (Elaphe) mouth hnw recently bsen 1dent3tYee1 ((~1112r~~an- and Glark, 1981, Can. J. ?ool. )7hese elevate following each tcr~ue r<tt~iot~oa- (FSg. 1). 9cffinir3g electron microscopic exawinaticn reveals the process' siu is siiOMi- aa11 then the duct to the vomex'ausal osgpn and the bi2lircate tongue nsiaes vertrel contact with these processes on retraction. Each process is thzoiwn into UMWvwee lolds and at hdger moUifications sagittal and peraasgittal pores are found on them rsdon. Dossibl.Y as openi$s to nucns glands beneath. This rnreserns strong evidence that Lbe anteriaQ' paocesses pick up ehesieal infbamatian il^cm the torgw and mediabe-Lhe ftral trats4fer'to Jacotieori's (wmawm=l) aagan. -.,.~..-m..~. p~0 0 0 2 5o44 .- ,..,f
Page 270: wrm95d00
5433S 2772 T An. Geophy. 58(6)465(1977) I2I. Du2 77 STUDIES OF STItATOSPIEitIC AEROSOL CBABACTERISTICS 6TITGt S.P. A ONZ-DIHI:NS20NAL MODEL, R. ?. Turco (1 a D Associatbr Mariwa /fTllDl[S C/ lT/U1x4rpLlllC J1[DOSOL -or CXIIRRCTL111STIC! MITr A OML-DIMENSIONi1t. / /q0[L/ 1 99211) "IRlMs (all at: N16s A.es sN- search Canter, Notfott Tield, CA. l10~3) Us .tillsa a one-diaenaional .odel of th. stratospheric aerosol layer to co.- pare asresol theory with observational dsta. Our sodel eoebines the details -et yss-pbas. aultor photoaha.istry vith tr PhYsiaal aerosol a.chanisws of •uel.ation. coagulatioa, s.due.ntation aM diffusion. lfodal predictions of aeresol sire distriDutions and t.le Iwriybt and intwity of the aerosol IspK at* corparsd to aeaaureaents. !Us .tf.ats on the layer of pollutants, includiny aluainus o:ide dust eyected by .pacd dwttle boosters and sulfur dioxide smittsd by aircraft engines and volcanic activity, are discuss.d. The aenwection of observed aerosol varia- ` eilitr with chaeyas in air t.rperatores,~ wowidity and transport rat.s Wlor ) ,0 kilawot.rs are also inwstiqated. 0 5 0 0 0 0 2 5 0 V I t
Page 271: wrm95d00
50335 2784 ; CdMPi?TFR SCIFNCE SERTES/ C(1MPTITRRS--PP.nc;RAMMM/ nA 76 Mc 1975 Clement LMcGowan John R. Kelly IROWN UNIVERSITY FIItST EDITION PEfROCEW/CHARTER ~IS0 >~ 6 025 0 1 3
Page 272: wrm95d00
VIII }lpm-ne, v, F. Ho Ur fmp dtr so:; ;trunS Ur+ot arareati*:.tm"s von f.awkm ~
Page 273: wrm95d00
50335 2783 HS 801 Do 1975 _ 1 i 76-28i262 ~ pOWI, Joe -Austin, Jr JW EMP IP .ICW. ., 1946- ~ IPICW. EXAf+Q~tisTIOt~ OF SUYER l~EtWYIOR: INDIYIDiJAt ANtD P,CND i - ~ .~..~--.r . Purdue University, Ph.D., 1975 Business ldministration ~ . I t . . ; Xerox Un=verslty Microfilms, An+Areo..micmw.elaa .._,-, ,.. .. . w ~. _ .._- , '-~- ~5.0 00 0 2 5a72 t CONSUMER BEHAVI OR/MARKF:TING RE SEARCFI /COFFEE / DISSERTATION--PURDUE UNIVERSITY/ MARGARINE/FLOUR/ DETERGENT/JLTICE/ShAW00/CEREAL/ HEADACHE REMEDY/ ' . l l
Page 274: wrm95d00
"ep, W,, F. 7.aa* 4`r"e A" ibv 4•6T1iss una arat+~~i S3 erbn~ von tAbOm 4'rm-s k ~ c u ~ 36i~ 3~ ~ ~5~,'
Page 275: wrm95d00
50335 2779 ,g ; Sc::-.ct_t'z, u:ltv tn .Ts iL:A?tT by riL+aVs ....' / 43.wV Jr', a J .. 'v 0 .•• • . . -. LGo1'q ~::.. .. bp .~ -. nsao 3o Card!ol,. i I2 (A'o, 2) 15i-6$ '~rAigs ~':u3) 0 ~ . _._.--.~-. . ~5Q000XSO4$
Page 276: wrm95d00
Homann, W. F. Zur fr&7e der SoRierung und aromatisierung von tabaken Photostat from: DuFtsche Cenussmi Hel Zeitschril't 5, 308, 329 (1953)•
Page 277: wrm95d00
50335 2780 $trit. 7. Anacsth. (1967), 34, 405-/Z CHEMIST{tY OF THE IN VIVO REACTION BETWEEN HAEMOGLOBIN AND VARIOUS OXIDES OF NITROGEN , sY Dapartment of Chemical Pathology, Um>•ers:ty of Leeds, England BUUIKARY Massive conversion of oxyhacmoglobin to methaemoglobin has been found in a series of anaesthetizcd dogs exposed to nitric oxide or nitrogen dioxide in concentrations of 2 per cent, 100 rer eent conversion occurring in one case. Less marked changes occurred with inspired concentrations in the range 0.1-03 per cent. Reduction in oxygen capacity contributed to the death of some dogs in the series. Almost complete reconversion to oxyhacmoglobin was accomplished with methylene blue. There was no evidence for the formation of other compounds such as nitric oxide-haemoglobin, nitric oxidc-mcthacmoglobin and nitrite-mcthacmoglobin. t Certain oxides of nitrogen may react with scopic data presented, and in the latter two hacmnglobin to prevent it acting as an oxygen reports the compound was detected by the eQrierSTlac &rn~m e at~ b~evc® ta6be 9yualitative test described in Harrison (1957). torme~.' Firstly nitric oxie fotms nitric oxide- Nitric oxide reacts with hacmoglobin in the hactnoglobin, a compound anaieLous_to oxy- or samc u•aY 11 ~?~o!:~~aet~?nd,~~n tnn„ r,aclr. g
Page 278: wrm95d00
_ 50335 2782 t XX MeF-B-4106-7 3 Observations on the tlsc uf 2,4-tiii.itroph I~}'lII}~c~raiirre Zrid of 2;G-cIicl3lurcrPlz~:~~~linclc.~?,Cifc?! r{z~~•r • for the tlctertnirtation off vitarnin C in and in licat-1r rt~ Jour. Dairy Reseerctz 3/ '1 S. Y.`'lTOiPSOti nxD .1.~?: .r ~ ~'ali07rlr .~71Sltl~llc fUr •j'iCSc~k/•Gi in TJairyi~.v, wIIINl•lraT:~'. A StLKIy }las been 2na(Ic of inethucls (7)\P3:) or 2,G-dicliiuruplicnolindupL'cnul (I)CP} .`ur ti,c• ci,~:u.rn::,~a;~~,z C(asc:orbic ari:I-{-dc•l:ydroascorLic Zcid) in rav.•, UJIT steriiizc•d milk. ~Interfc•rino,uLstanees were not deteeted in r•iillc that1~: u r(c,_i'. E.• ; ~. , ^*, tuo Inoec scvcre than ]•]5 `C for 1 s(UJIT proccss), so used. 1~'it)E mcrro dr.atic l~eat; td'P~~trnellt, is~terfcril~o suLstan, < < . . ,, f, , „ ;' , ;. ~ 7)~TPII I~ic:nr~,i ~~.•itir colu~nu a~IC2 thin la~'. r cl,ro~r~~tu~r.~ .ras : hcc:ifac fur• vitmi~in C. With in-butt.ic sterilizccl ntil;: tircrc (i;~ »:~/IC!1 iI,l) 7•}G (17CP Incthu•? ti•;sfl! lI. S r c,•1uc. 0 5 0 00 -0 2 5 0 7 1
Page 279: wrm95d00
. . .: ~.. ~ 50335 2773 S. P. ~~ 80 I I Ey410 Hsbltnstion of PhystolagKsl Responses in Anxiety ~ : Cbsttopsa?!ay.' Ladsr~ ROcwMed 1rdy 2. 1979,• rf en[d Fi+bnnry 4. ilMJ ~W t* fl~rst study. 20 nraLe and IV fentak volurrtetm were studied under tftrhat-of shock and no-threat conditiotss with respect to anxiety kvels, skin roaductqnc+r. E'EG auditooy ewoW resporrse. and alpha-blocking variables. TTnt t1lrNqt-of-sb•ork wcsewr4 arxiety levrLr, skin conductance level, and Awt+mftoRS. The P,„ conqPoRew of Ar AER was presattr in anxious hrd€vi~re~s and habituation of the alpha-bloc*i+rEt+irspo+e~e w~os retarded. 1n ll~ sftwtd sttadfy. 12 anxeods patients were compared with 12 normal strbjiwtc under thrrat-of-skock and 12 mrmal subjects under no-threar. A'rrxiffy wss associated with increased skin condbctance JXt+ctuatiorrs, larger P6r AER comporrmts, and impaired habituation of the atplta response.
Page 280: wrm95d00
- The determination of vitamin Cin e~•aporated and fortified sterilized milks 37 F~%i_;y7 ~ t - ~•- -- -- , . I I 1-.-N r ~: BY S.1. THOJII'SOX A\D W. B. HILL i Nationai Institute for Research in Ikirying, Shinfield, Reading (Reuired 27 May 1970) ( .- -, . . ~ The DCP nicthol r+ive erroneousl)• high values for the AA and DNA content, arid ~ the lower values olttained by tlye DN.PH mct•l.iod with bromatofirfcphy of t hc 1)\ ]'I1 ~ ~ !~ rJ ~ 0 QdA+itoesZ'Ixsl (ial 7'lins fi,raa evaporatcc) milk, tlie ve luecfor v i::.m it3 O r- i .Mntrnt (:1:1 +]1}{ A) wcre, in mg; 100 izil rcrcm,-ti!uteCl n111I:, tt ~~ (3)t'1' nit-iL•t.J 50335 2791 ; XX MeF-B-imp SD3fM1lRY. A study has been made of the use of Z,G-dichloroFhenolindoPhenol (DCP) a,nd also of 2,4-dinitropheny 1h}•drazine (DNPH) with and without chromatogaphy oL'the DNPH derivatives, for the determination of ascorbic acid (AA) and dehydro- ascorbie acid (DITA) in evaporated milks, and of AA in AA-fortified sterilized milks. In tlie))~P}1 1ntt!; tl,m-heninterfering compotuidswerereinov cclby tlicchro:r,zto- graphic separation of the D\PIi derivatives, absorption curves typical of the pure t DHA dcrfvative were obtained : • a
Page 281: wrm95d00
M nMIS rAUKSe (Tap-:.•anl$ing of Tobaccao) SeliCFipiGd6r iZ9it'mr (usT a (IZQa b' ) I51-U2 (1947)
Page 282: wrm95d00
Welt 50335 2791 . _-:s RJR CLASS NO. PAMPHLET 73 XI Fol-.75 s.p ~ ~ *(Top-Hanager Manfred Emcke verlaBt Ende des Jahres den Hamburger Tabakriesen.)* Welt,(July 30, 1975) (in German - complete English translation available.) 0' 5 0 0 0 0 250 80
Page 283: wrm95d00
50335 2792 RJR CLASS NO. PAMPHLET 73 XI Fol-75 welt TOP M11XAGER MANFRED ' TO LEAVE GCO GIANT +A,T TKE END OF THE YEAR. IT 'S"SMRKING" AT T#M ANY. Velt,(July 30, 1975) (in German - couplete English translation available.) t o s o a ~©2 s o8
Page 284: wrm95d00
76 7CI,Be-79 5Q335 2789 S.P. - RJR CLASS 1,0. PN-'PHLFT 76 XI Re-79 s.p. ~ i , Toronto, Canada L'~!~ 0RE Ci11~if~ "LLENGING TORe:ITO'S ANTI-S'~0KiNG SYLA'-4. Sop Drug Mart Ltd., news release, Toronto, Can. (Oct. 1973) - in Engl ish *Abstr. in: London Free Press M3, n.p. (Oct. 9, 1978); and St. irathe`rines Standard 157~, n.p. (Oct. 7, 1973 * Ir _ o s© 0 0 0 2 9 0 7 8
Page 285: wrm95d00
50335 2790 HD 69 _St 1969 I ARCHER - ~ ~/".~.. . BY GEORGE A. STEINER r3... ~ . C ~,: . ~ . . ft THE ASACAIILLAN COMPANY AN ARKYILLE PRESS BOOK '1'SE MAC!1[ILI.APi COMPANY OOLLIER-MAtadII.3.AN IdMITED, LONDON . 3), Qv',15otj 05~0n 0~~s 0' 79 N
Page 286: wrm95d00
~ HD ~ 69 Bu 50335 2793 '3s*Iers John A. ,Su .r zN a ..r~.~iv-eta [itt~}c'Su ~s .~:. -... ~ sctiva~s, by .'isFli7 A. but:~ef and EaiLh 1. Wrden &I- .14G5 57 flAt03 Stzsxio:d kastxrch TnstS.tuL•s Mezio Calfi'. 0 5 0 0 0 0 2 5 0 9 2
Page 287: wrm95d00
50335 2799 RC 263 Pi .1974 THOMAS Y. CROWELL COMPANY a8resr.tsxEn i834. NEW Yosx NFAPLASMS / LMUAt7r or coxGSac c.rAwcnvc nV PVSLtc.rloar n.rA pggdm . ka. The topic of cancer. Indudes bibHograPhical refereaoes s. Cancer. L Title. (DNLM: i. Neoplasms-PopuLs works. QZzoz P638t 1974) XC2W56 1974 8s6964 74-'15M nm 0-seo-0051e-4 / IRA FILGRIM
Page 288: wrm95d00
s # NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY/ • Edited by GEORGE C. LEVY Department of Chemistry Florida State University Tallahassee, Eiorida Yoiume t ; . J A wiler-Interscience Publication JOHN WILEY & SONS, New York • London • Sydney - Toronto 0 50 335 2801
Page 289: wrm95d00
t litNAt: tlitNAt oF GBWM~ RESIvIRACii 50335 2777 TM t'>, M c!2 ',r,•d2e7~; l19 Jo Nitrogen-Sul#'ur Compounds in Stratosphcric Aerosols Naa. H. FAsu.aw Anio KemNrm G. Srtrrsm>s .LraAexrt+ei G.rer, J1uuSA. Modar ffegt c.Wa..i. sMR1C! _ T.ro fortns of eitrosyt sulfuric acid (NOHSOM and ?fOtt5,0,) have boes teaaativey idenYtficd 'w tllestospheric aerosob. The first of these can be formed either directly from Eas reactions of NO, with SO. M by ps-panick wteractions between NO. and H,SO« The setond product taay fornt when SO, is Ir+eiveQ. Estimates based on these reactions suggest that the maximwn quantity of NO that mnht be N.erled 'w suatospAeric aerosols could vary from one-third to twice the amount of NO in the surraund. bg air. If these reactions occur in the stratosphere. then a mccbanism uists for rcmvrin# nitroEce oxides fiMS that rejion by aerosol particle fanout. This process may typify aswher natural auans that helps tkwe tYe lower stratospbera of esaeuwe pollutants. ~ Itnrttooucnort Utraee oitrogeo oxides could read and wmbine.ritA sulfur compounds in stratospheriaae:osois,t mechanism would e:ist br remorini nitrogen oxides from the stratosphere by particle filfout. Such a proeess mieht renresent another natural means wLpeby the lower stratosphere is cleansed of some portions of oofWtit:g materials.' lts confirmation depends on finding nitro- lliiF ~tic~ a~ni en(,~sidY in~ltem s'~ato~ierw rolp (NH,),SO, has been found in stratospherrc auosols (Friend. .,.... . . $fOy, + NO iY N,O,' s The extent of this reaction controls the subsequm Wrtnstios of oiRrosyl pyrosulfatc 3NsO, + zS0„ _ (NO)„S,O, +.NO . - - P) Another reaction that kads to the forrnation of aitraoyl sulfate is described by aoraaaoo er al. (1966k 2NOs + H,SO, - NOHSO, + HNOr If an ae.em.nl f.xwted Mr. I
Page 290: wrm95d00
50335 2?94 Xi. ci . _ ..il ~OR E. C:r.rk & F.csoc., In^., S;atgforc, Cay _ '!'OF TE'<'-. BRt,::DS tiMOSS THE hATION. CC:S ?:'2'J GC",". "`.EM Z'"jr ;j'~~vRY F3 R 1360 EAS;:.D ON `013" p,Ui>i.s Fs.~.i n:a3. PE^.r.,v"OaAL IKrERVIErI S:::aEY OF '-VEN Mh..3vR !-.UME. MRK.,.x'TS. Dar. Eo Ciar% a tiqeQc.,, 64 pp., I9c~U t 050.0 0 tl.350$3
Page 291: wrm95d00
50335 2796 BRAND LOYALTY/TOSACCO--ECONOMICS/TOBACCO--MARKETING/ 81 XI To RJR CLASS ND. PAltPHLET 81 XI To , Skokie, Ill., U. S. GENERIC CIGARETTES SELLII~ WELL IN SO~t$ STOEES, '8CT' I~iD11ST'R YRY BELIEVES MARKET FOR TliEMI IS. _SNALL. ,, J Topco Assoc., Inc., " Release, Siud<ia, I1I. ,,~1l80) (in $nglish) *Abstr. in: Supernarket Dns. 1980, p. 26 (Dec.1900)* Initial reports from retailers indicate the plain wrap cigarettes are selling well. So.e grocers, in fact, claia the a~rics srs arong their top selling cigarettes. But other retailers say this is doe to bisfi trial use, and that the real verdict eou't be ia for at least t few .mths.... 0 SO0 0 0 2 5 0 85
Page 292: wrm95d00
50335 2002 QD ` 549 in i 1970 1971 INTERNATIONAL REVIEWS IN AEROSOL PHYSICS AND CHEMISTRY • YoLUME 1 _ 19 70 THE j?YNAMICS OF AEROCOLLOIDAL SYSTEMS _ .G.- . _ YoLUrss 2 - 19 71 EflrrrD sY PERGAMON PRESS G. M. HIDY or • x k • Tor nt o 0 r Stkace Centtr, North American Rockwell Corporation, 7boxtatrd Oaks, Cal,jforrtia 91J60 AND J. R. BROCK (Jr&+ersity of Texar, Atcrtin, Texar_ or xjor W t Sydney • BraunschKer'g 0 S 0 0 0 0 25 09 1
Page 293: wrm95d00
/COMPUTERS--LITERATURE/ MASS SPECTROSCOPY/ SYi3TIiESIS, ORGANIC/ /CgROMATOGRAPHIC ANALYSIS/ SPECTROCHEMICAL A[dALYSIS/ QD Computers in Chemistry 39 To 1973 ortschritte der chemischen Forschung Now S ger-Verlag Berlin Heidelberg NewYork 1973 vs©oeozso93
Page 294: wrm95d00
.44 . 50335 2800 r , CHMSTItY, ANALYTIC--AUTOMATIC/CHEMISTRY--COMPUTERS/ TECHNICON AUTOXNALYZER II/ TOBACCO--S`tOI:E--ANALYSIS/S*iOKING MACHI QD 75 Po 1979 2 C. ELLIS HORWOOD LLMITED Publishers Chichester Hwls6ed Press: a division of JOHN WILEY & SONS Naw Ycst -Ckichater - Bsbbase - Tqionto 0/t/ . .c .4- 0 5 0 0 0 0 2 5 0 8 9 ~ Editors: J. K. FOREMAN Deputy Director, National Physical Laboratory, Teddington and P. B. STOCKWELL Superintendent, Research and Special Services, Laboratory of the Government Chemist, London ,
Page 295: wrm95d00
50335 2797 `-~761IRe-'l6 s J S.P. O_T~ by Roy C. Darlington A ntimicrobial products which are designed [or : topical application to the mucous membranes of the oral cavity or mouth and the oral portion of the pharynx, include mouthwashes, throat sprays, gargles and troches or lozenges. For the most part, such preparations cont~in as active prin- ciples the so-called general antibac- terial agents. ~ Such preparations are not .videly prescribed by medical practitioners. A reliable survey shows that they coin- prised less than 0.4 percent of the ap- proximately 450 m'illion new prescrip- ssoc. NS8(9 484-496 (19 3M oral health. The council has classi- fied medicated mouthwashes which are marketed for unsupervised use by the public in Class D, meaning that such products are unacceptable to the council because the advertised thera- peutic claims have not been demon- strated.s The public usually regards mouth- washes as medicated liquids which are designed for cleansing and de- odorizing the mouth or for trcating diseased conditions of the oral and throat mucous membrane. When necessary, pharmacists should make it on the normal bacterial flora of the mouth (4) The pathology of the oral cavity and throat (5) The diseases of the mouth and throat and their therapy (6) The bacterial spectra of antibac- (7) terial agents The potential toxicities of anti- bacterial drugs Excepting the knowledge for diao nosis, pharmacists should have the knowledge to evaluate the uscfulness and the lfmitations of topical ojal anti- septics in terms of the aforesaid flwd-
Page 296: wrm95d00
50335 2771 IdtiRNAL OF APP tED MHTEOROL"t1GY S.l. 2 R. P. Tunoo RA D Assacl.res. Afwiwa lel Rey. CA 91/291 SdWospheric Aerosol Modification by Supersonic Transport and' ~.~ iZI D. -8o Space Shuttle Operatiaas--Cibaate Imptications um 010 ) ` - ~ t, ~-e- . .lt • . B. POLLAC[„ R. C. WHITTHN AND I. G. POPPOFF A+st: Rtse.ndt Cewer. NASA.1tq$'ett Fiei4 CA 9/i0W I P. HAwiLL ,SYsfsses esd Apprrd Sctsnees Co.ptrn.tioe. Haxprow. VA 23I6d6 (Idaometipt received 10 Apri! 1979, in Rtnl torm 28 Septesaber WM ABSTRACT I 5 We have estintated the potential etiects on stratospheric aerosols of sope*sonic tsansPort eatiss;oas a[ staritr dioxide gas and submicron soot granules. and space shuttle rocket emissions of alnamann oxide p.aticulatas. Recently. exhaust particles from Ftw airctaR and rocket enynes have been c4araaaued experimentally. and we have adopted new da.a.vhere appropriate. We use an interactive partide•ps model et the suap4upbaic aerosol layer to calculate changes due to exhaust emumoa& We also emPby an accurate wdiation transport model to compute the eRbct of aerosol changes on the earth's averatae aqrfact:.teatpenttm. Our ma,jor conclusions are as follows. The release of 6oYe numbers of snall par- tidas (soot or aluminum oxide) into the stratosphere should wor kad to a cofsespoaditg silnificant is- cteae ie the concentration of Large, optically active aerosols. On the contrary, the increase ie huW ppRieles-is severely limit byt~ oi sul{a~e available to make large particles Hr s+u+, and by Q~~SS /~ snse~ parQks~a~utation. We find that a fteet af several hundred advanced atnKR untt dat~y at 20 km. or the launch of one space shuttle rocket per .veek could produce ronshly a 20% increase in the 'arse-particle concentration of the stratosphere. We find, in addition. s I
Page 297: wrm95d00
50335 2803 :...•. J. •R-BRQCK .... .: : F . . uai.r,r., of. re=a,. A.,nA. r.xw ~iTER1QATI0NAL REVIEk'S IN ROSOL,PHYSICS AND CFiE.`iISTRY, ~ , T ~ ~.: . ,.;~_ ~._..........~ _ (PART 2) i/ol• .3 t . .. ~ . . G. M. HIDY ' .fde~ar Gnto. lYRa1 Aw.eriean RockwIf Carloretipr. SfassrdOrE,. CaGJweia9rd60 ' AND PERGA11fON PRESS 1Vrw T4.k' • `Taroii[o . . :•.; . r . . ,. _ syd-7 • e.aunschwcla Li flrrlr~I QD ~ 9 In 72 , i i -a__ 0 .".4-. 41)
Page 298: wrm95d00
4 26Z To 1975 SYNTHESIS, ORGANIC/ 50335 2805 Fortschritte der chemischen Forschung Library of Conbress Cataloging in Publication Data. Main entry under title: Organic syntheses. (Topics in _ qttrent cbanistry; v. 59). Bibliograpby: p. Sncludes index. 1YQtemistry, OrQaaie = SyntbeAddresses, etsays,ieeturec. L Series. 41-' Organic Syntheses Springer-Verlag 6ertin Heidelberg New York 1975 0 5 0 0 0 0 2 5 0 9 4
Page 299: wrm95d00
r: . BEHAVIORAL SCIENCE/PSYCHOLOCY, PHYSTnLI)(:ICAL/STRESS/.MEDICI,NF., PSYCHOSOMATIC/ DISEASES--CAUSATION & THF.(1R1F,S nF CAUSATION/LmGS--CANCRR--CAUSATION/ RYPP.RTENSION/ CANCER--CAUSATInN/HEART--nTSFASF.S=-STRF.SS/ ~ edited by Rarl E. Schaefer/ RC 49 { He ~ 1977 e Stress, Health, and the Social Environment A Sociobiologic Approach to Medicine J. P. Hezry and P. M. Stephens - Springer-Verlag New York Heidelberg Berlin ~0 00 25096 ~
Page 300: wrm95d00
9 6 0 SZ 0 U 0 0 S 0 I ~ . .. .I ..i ?. r.~f :. 'J74 ? es. _ . ..~ . .. i,_ .. _ _ _ J
Page 301: wrm95d00
e_1 ' .,.. .2~~tg-~?3~ ~ w A Oae-Dimensional Model Describing AerOsol Formatiot and Evolution in the ' i i i Dg -i 4 Stratosphere : I. Physical Processes and Mathemstu~l Analogs S.P. 2 P. Huau.,~axb R C. Warrrax , A+ws Ra..nck C.aaa, A'd8d, Yef.W F;dd, CoNf.sfs POW C. S. SIMcP 1Pebe.al Cswkr f.r Qearos1lfrafc XamrJI' Banlder, Coferai. d03D3 Qlaomaipt received 13 May 1476, in 5aal fonn 8 Deoember 147i) A8S!'RAE:T We Imre developed a time-depcudent one-dimcasioaaf model of the stratospheric sulfate aeeoaof layer. In oonstructinE the awdel, we have incorporated a wide range of basic physical and chemical processes in order to avoid predetermimng or biasing the model predictions. The simulation, which eztcnds from the jurface to an altitude of 58 kat, indudss the troposprbere as a source of gasa and condensation audei aad as a siak for aetvsor &piets; however, troposp6etic aetosoi physics aod chemistry are not fully analyzed in the present modeL The size distribution of aerosol particks is resolved into 25 discrete siu eat+eprisan carcring a raitge of partick radu from 0.0i-2.36 pm with particle volume doubling between tsfto:ies. In the model, sulfur gases reaching the stratosphere an oacidisei-by a series of photochemical -re.etioea iato sulfuric acid vapor. At certain heights this results in a supersaturated HISt3,-IhO gas coa~guety~dep~itio~.ef a~eous sulfacie acid aohetion oa the surfacas of a~~d«s+atinn. ._._. fficture t © ~ ~ d 2 5 e,j ~ 7
Page 302: wrm95d00
50335 2816 !<. ., T p y, ''~~ni'~'hiteman Carlton, 1886- Topley and Wilson's Principles of bacteriolog7 and immu- nity. 3d ed. Rev. by G. S. Wilson and A. A. Miles. Bal- ti i more, Willir.ms and 'Wilkins, 1946. 2 v. (2054 p.) illus., ports., diagrs. 24 cm. Includes bibliographies. 1. Bacteriology. 2. Immunity. i. Wilson, Graham Selby, 189b- joint author. n. Miles, Arnold Ashley, 1904- [Q,R4G.T ] 616.01 A 48-fi365' North Carolina. Univ. Library for Library of Congress 1510ij
Page 303: wrm95d00
50335 2811 i Fieser, Louis Frederick, 1899- Topics in organic chemistry tby, Louis F. Fieser Diary Fieser. New York, Reinhold Pub. Corp. ~1963, (3(f8 p. 24 em. Includes blbliograghy. 1and, , ; 1. Chemistry, Orgnnic. i. I'feser, Ilfars A. (L'e(ers) 1fl03- 4 joint author. lr, Title. . I 1 QD251.FG3 ~-, 547 63-13444 ~ ! 3 Library of CAD/;rBP(9 `~ =r f7-11 0 5 Q Q t1 tI 2 5 1 0 t?
Page 304: wrm95d00
50335 2612 QD 75 ~ Ad ~ 58 R.d.pr.nces in er_aZpticai che^nistry and inatrumsntation. v. 1-7 New YorK, Interscience Publichers, 1960 Cf v. il.lus.,diagrs. 24 cm. ~
Page 305: wrm95d00
50335 2e10 . _. n; 403 Aa v'O ,. ~~,.. Raainowitz., Joc+tph L Topics in medicinal chemistry, edited by Joseph L. itabinon itz aiid Ra)ph M. Myerson. New 1 ork, Inter- srience Publishers t1967-)19 I.". - V -"N. - a C. ilius. 24 cm. (An Interacience series) Includes bibltograpbiea. 1. Chemistry, Medical and pharmaceuticaL z, Myerson, Ralph 1l1., joint author. n. Tltle. RS421.R3 _,s 615'.19'008 66-28541
Page 306: wrm95d00
50335 2813 QD ~ 412 s. T IK, 7~ 'faZIS4= ~ J, „2.. Topics in phosphorus chemistry. v. 1- 14 New York, Interscience Publishers t19G4- qv. illus. 24 cm. F:ditors : v. 1- M. (lrayson and E. J. (lriffith. 1. Phuspli,rus compounds-Addresses, essays, lectures. i. Gray- son, 1linrtin, ed. ii. GrifBth, Edward J., ed. C,Zll181.P1'1'65 54G.712 6-1 17051 l.ibrnrY uC CuviKrrAS - ]7-11 ~ 5 Q 0 n A 2 5 1 tl 2
Page 307: wrm95d00
50335 2815 QR T6 ,- r f • ! Topley and Wilson's Principles of bacteriology and immu- nity. 3d ed. Rev. by G. S.1Vilson and A. A. Miles. Bal- timore, Williams and Wilkins, 1946. 2 v. (2054 p. ) illus., ports., diagrs. 24 cm. Indudes bibliographies. 1. Bactertologp. 2. Immunity. z. Wilson, Graham Selby, 1896-- joint author. ii. Aitles, Aruold Ashley, 1W4- [(,1,R46.T ] 616.01 A 48--7365' North Carolinn. Untv. (. ,>> Librnry for Library oi Congrt:sis 151c'71 o s o o t~ 0 2 5 1 0 4
Page 308: wrm95d00
FOOa--PAESERVATION--LM' TEt3PEP.ATURE/ _ Buil. Inst. Int. Froid 52(2)265-84(1972) ~ ETUDES D'acTUALITE AIR HUMIDITY AND ITS MEASUREMENT AT lOIVIER TE?dAERATllRES (1) G Th. S.rar~as ~ - • beiR Ce1..t%itY ef Technul«w'v ' Laliot.torY of ttrfrigrratiun a.d 4`.w1 TKMn..{oty t'HUM1DtTE DE L'A[R ET SA MESURE AUX BASSES TEMPERATURES ' Lt tndriarat'ton technology the realisation of optimal conditions for the preservation of products t.=. optimal humidity in the storage air, is an economic necessity sonce dctetiontion ir product puatity, as a function of time, due to spoilage and desiccation remains at a minimum. Air humidity must be known in order to be able to calculate the perforsnance of air coolers with condensation because a considerable part of the cooling apzcity is necessary to carry away t6e latent heat of condensation. Other examples will also show that, in addition to air tem- ptratwx. ti.c•A.a'nidity is just as impoctant a factor and in twny cases must be known and Ifien calculated or measured. ' Measurement of hamidity in refj'igeration technology is d"uffw.-utt to pcrform. A single quo- tatioa from the t.LR: rtcommenlations for the processing and handling of frozen fos.+ds t 1964. p. 161 jSj can illustrate the present unsatisfactory situation :. In order to reduce the desieta- fioo of frozen foods. relative humidities in cold storesk~houl.Lbe~biyb as possible .: a footnote says a It is~t pisiblOo s-ify~ee`~Ip {~ Cred ~/,m iqayld swres. because instruments for measuring humidities at eselow• temperatures arc not commercially avsi- iaable_.. .
Page 309: wrm95d00
78 III Re -81 ANNOTATED OUTPUT FOR S.P. 2 BMDQ 4V (URWAS) 50335 2819 , Technical Report No. 56 Supported by National Institutes of Health, Division of Research Research Resources Contract No. N01-RR-8-t107 8[W Statistical Software Department of Biomathematics Uni vers i ty of Ca l i forn i a, Los lingel es 1979 0 *fl~00 2 5 ~ ©a
Page 310: wrm95d00
Phys. B. 32(12)564-71 (1976) 73 II $e-77 t s'~T by ~g grazing ir.t~dence mirror S.P. X-Ray LILho- ~ optics [3] have not been successful up to sow. The aberratiuns oi grazing inci- ' graphy and X-Ray dcnce "stn"menu and the difficuitics in producing the design^d surfaces have li- ' sutod the performance. Normal inci- croscopy dence reflectors using mul.:layer coatin;s promise proFress in the future, but arc D7 E Spiller, R. Feder, ~ wot ready oo be used at the present Yorkwan Heights, N.Y.*) time [6, 7]. Optical lithography is widely used Tbe potential of x-rays to produce today for tlhe fabrication o: microcircuits. aapes of higher resolution than possible In the sixties it became rlear, that fur- with an optical microscope was imme- ther sainiaiuriutioci would soon be limi- dtaWy recognized after their discovery. ted by the waveleagth of visible light. Howe.er, Rarntgen already realized that -Sc.umieg electroo.beatn s,rstans which de available differences in the refrac- have drastically improd ed resolution tis iwdex of materials are too small Eo capabilities have therefore been devel- . a11ow imaging of x-rays with knscsL oped [>i]. These scanning elecucn Probably the first application of X-rays microseope srsccros have several disad- to msamcopy was the microradiogrsphr vantages for the . production of micro- ",~-' ~,,.
Page 311: wrm95d00
~~-1 SZ"ov0nSt~ 0 Xwx MH (fmTTH) wzusj*Q2a3ul ' BI'oA C 6°1 1996T ' L96T TaTTH '1 'H Pue sv33TTTY "I 'N Aq h`f-T •ZOe aazsIHMO~:~s.~i~= aaut ~ ~ ; ~ thl" ~aad ~ ~ ~ ~rr ! .r.,-~-----~~- -- ~ ~- f -- ~- .. 11 bLaZ SEEO9
Page 312: wrm95d00
.1 50335 2820 . • w . ~ Un 1979 PWL . 'l i M1P4 rith G.as2 C.11 Hof<bts Mtebasl L. Dsriis.a sed ~~mm tpswzsscT ef AWb.stor p : =setw{ w.1 Swart No. ~ / 1i1t aiatit.tieal 7iof Jluara s.p.rerot .f ssostbssties WhAversiqr of CaLtforata, Los Iunsel.s .
Page 313: wrm95d00
50335 2817 71 II 01 ,. -- _~.._ --- - T~(?GRA~H~CwBAG~~.~i93~flF HYPtYTHAi.l1KIC SELF-4sTIMtiLPcTIM nVCTiONS. Olds, 3. TOP3";t1aSlIC 4RGA„dI'L~TIO.d CF FzwrO^Fr,s.RfE-C M-r_<;TDT3T ATT'?N Pif:?CiIU.S, by J. (ads, P.. P. Trrsvis rmd R. C. Schking Jouz. Comp. Phyc.iol. Psychol. 53 23-32 (1960) 4 o s o 0 0 0 2 5 1 0 6
Page 314: wrm95d00
I 50335 2008 ,. ";~- - -- -r ._. ~..~.- ., . ,,: ... ENZYMES--INDUS'1'RIAL APPLICATIONS/ENZYMES--IMMOBILIZED/PAPAYA/ ALCWL DEHYDROGENASES/COENZYtES/ ____ - ~- M :. Q' 601 .10 1981 9 .0 Editor: ALAN WISEMAN, Ph.D., F.PLLC., M.I.Biol 8iocJtembtry Divisan, Department of Biochemistry t7niversity of Surrey, Guildford F.t1]S HORIMOOD LVATTED Palbfh6ets - chddrout: Halsud Pres: a dtrfsion of JOHN Wn.8Y d< SONS jt... Yak • L2idnan • araban. • Tosa.co 9 7
Page 315: wrm95d00
,....~.---_ Jottt: A. Buw.}:rc, Indt!strial I:coriorrmist a SI)C?Ctal i"G'SG-'Q'?'Ch SruC1.1t [I j1 Ent•ru I:. N1')•:>t:x, IZcscarch :lnatyst carrit J istitutc ;t:ut(crcd Rcs Ct,trtrit,ution; Ur t[,i> retwrt %~-ere nradc 1,}• Uorc;.As :1. Ht'r•:n. 1r:du>trial I:corrntnia Stantord kc=each Ir.:titrrtt 50335 2822 o s o o n 0 2 5 1. 1 I
Page 316: wrm95d00
50335 2816 • r!_HM'N/a INI:nANY fI, '02-W7 (Iy1t11) 80 II Ey-80 k-),{ - S.P. .l _ SHERRY W. PITCHER STEWART MEIKLE UnirersitY of Cefgary assertion Variations in assertive response topography and in the type and frequency of n*orted self-statements we, studied in positive and negative assertion situa- tions, with male and femaie. high and low assertive norrnal adults. Significant dilfe:eaocs in behavior were found between iri=h and low assertive XrOaps, oen and rrowen, and positive and neptive skuatials. Sdf-stateraents and assertive behavior were sign' icandly correlated in positive situations, but not in nerative ~ 2 07 5 ~
Page 317: wrm95d00
~ 50335 2826 73 VII Re-73 TDBACCO.-ALKI`sLOLDS--V-uARIABI41-TY /•TOBACC@---T{3PPING/ TOBACCO--AGRICULTU1tEf RJR CLASS N0. PANTiIL3,T 73-VII Re _ 7``j WaLlace, A. ; Smiley, J. li. ; Atkinson, W. 0. ~ *(no affi1.)* CFFi;CTS OF TT:fF, OF TOPPING AND TI?fE OF HARVEST AFTER- Tohacco Workers Conf F; 25th, paper, Namiltcn, Qret. , Can. (1973) (in EnP: 1ish) *1973, No. 18, W 7089* *d* Tobacco agriculture: vs`non ~~st t~
Page 318: wrm95d00
.a Ik Re2-77 50335 2824 Aflterosclerosis, 24 (] 976) 527-53G ®Elsevicr Scientific Puhli}hing Cumpany, Amsterdam -I'rinted in T1ie Netherlands MIE EFFECT OF I\`TERMI'I'TEVT CAR1'>0\' \IO\'OY•Mr EXTOS.URE ON EXPERIML\'I'AL A'fIII:ROSCLEROSIS IN THE RAI3131T* R.F. DAVIES and D.M. TURNER *** ,a'obacco Research Council l.aboralories, llorrogale, Yorhshire (Grea(13riteirt) (Received 22nd December, 1975) (Reviicd, received 29th, February, 1976) ((Accepted 29th February,1976) Summary (1) Twenty•four female New Zealand White rabbits were fed commercial • .T*1 Iss./y". WnTtf+0) if IvPVI.'It1i1Tt8l5 wera2 C\DOSed
Page 319: wrm95d00
5©335 2828 1' ;.iAN1G£AS£N7" rrutions .trtalysis nd Prtdiction of Discrete I Economic Behavior ision: PFilosophical Issues tories, and Work Force pcrations kesearch sAstria( bla.-wgemtnt :on nns: Rules for Action and Industrial Applications of Operations Resear:.h W. J. Fabrycky Virginia Polytechnic Institute Oklahoma Statc Unis•ersity Prentice-Hall, Inc., Englewood Clijt's, NJ. i 4 ~ -ft- --8 ~- --E~ 2 5 .
Page 320: wrm95d00
50335 2825 i 4*~Ppfna and sucker -contrel .~~ :~3~?e-cure ;~ strwtt+, A, A; Tofpih~r~no/ s1'+cktJ` Cet1r*,Y~t ii't F~ttie-Ci~~ toDmMCicn, x: 1(.; semett, N. *VAR ond AS+or hrr,3. Ral.ti gfi, I%r#'f+ 0havAls 49SC4J tlara ( Wftnstoa QV:tc4,, jD1'tr A54. ~ sa_0 n 0.zs
Page 321: wrm95d00
I 4 Q 210 V Sa335 2827 Velazquez de la Cadena, Mariano, 1 4-; 3-1860, comp. A new pronottncing dictionari - of the Spanish and I;n('lish hilmiareG, compiled by ltaricuno Vellizquez de ]a Cadenn ... and Edward Gray ... landl Juan L. Iribas ... with supplc-mellt of new words by Carlos Toral ... Chicago, New York, Wilcox & Follett colnpany,19-1-1. 2 v. in 1. map. 25 cm. At head of title: Velazquez. On spine: Vehiaquez Spanish dictionary. Rev. & enl. Spanish- Englibh ; 2rn~li ch-~paui5l:. Part 2has t.-p. 1u Spanish. 1. Spanlsh lungua„e-Lictionaries-English. 2. Enr;liVh lanfiaag-c- I)ietinnarie;-fip:uiivht r. C.ra}'. Eda•nrd, 18a:)-19°A, joint cown. Ii. Iribms, Juan L., Joint comp. r[r. Toral, ('arius. PGIG4nX:, ]a-l t ) 463.2 4-1-~51-178 Lihr:u•.v uf Cuu,n•.;s ` 1:a3111, 0 5 0 0 0 0?. 5 1 1 6 ,
Page 322: wrm95d00
~.:w . . - ~..~ ,...._..~..~.. ~ ~~..:_ _ ,.._._.. ~,, . I 50335 2836 TMS PAF~9 S i,. LECT 1 lJ' i V 945 E4ST 47mRST EEC H£YV, ORK, N.Y~.~ OOrT ON THE APPLICATION OF RADlO- TRACER S 1 N THE ALUld i NUM ! NDUSTRY KAI GRJOTHEIM CONRAD KROaN ROGER NAEU,•iANN PAPER NO. . A71-16 •
Page 323: wrm95d00
r~ 50335 2821 BMDP Statistical Software I . . Un'iversity „ Of "a #~f"I'&, - Dept, , o# 8iowthemntics IV.J.SAW,~~. UNIVERSITY OF CAUFORfi11A PRESS _ . - ~.~ . . ~ k 4e R BERKELEY - LOS ANGELES • LflNDON - 1981 syy ; yE~:; tF ~^! !it ..~swi "S,.-1 ti t ?,'-~ . . . .. . ~t .. . 14
Page 324: wrm95d00
6 S z- 0 o U, 0 5 0 ~ sa~~~ GI£ ~~~? 41 S:ES_:'.;.:-,•".r7 'IV ..~.::.t, Y i a.e + Cl .'uT d'1 tl f n. CS • ~~V'S .Z . i) _ -.`.! ~.i - n1:~w=..d~:':~ -Ic-., ,.... ZS :4yd. _. J w~ca :e:a3~I:.t "I".al •SY.W40r:.rvy !Sl)t114Ya) t1 - ~."~ SS 'S7ST 6t'r tt~~~ y...V 1 :2LL i.r.1i~V+ad ~.J .. ... ; ~t ~..3 .31LY I~Cl J.YSi$' x I ~
Page 325: wrm95d00
X Me10 74 S.P. Jour. Nucl. Med. 15(6)504 (1974) AEROSOL DEPOSITION IIZ THE RESPIRATORY TRACT. KROSOL.DEPOSiT10N IN THE RESPIRATORY TRRCTfiiaru- W Itoh.%Yasushi Ishii,''.Toru Mori.:Ken ita"s,oto. ru Fuzita, Chizuico Furcr..atsu, yato U-niversity Schooi of rsec.ut e. yoto, Japan. Eaa i Takahashi. Atomic Energy Institu[e, Iyoto. n. The distribution of inhaled particles and s in the respiratory tracts has been very in- rtant problca in medicine. For example, air pcsllution or aerosol therapy, should be studied Womder the synthetic concepts of gas and particle. So aerosol scanning shculd be reviewed in wider ~ aspects of aerosol science to answer various e:linieal requirements. First, tota kand regicnal dk,position rates in human airways were caiculated computationaly. Next, depositions of 99artechne- tlua eolloid in bronchial models and the human. airways were studied by scintillation ca.era and Wbole body counter precisely. These theoretical 4 and ezperimental atudics were useful in under- standing normal distributions of ac•rosol and qas in the scintigraerrs. In healthy subjects, 133- , xenon gas mainely distributed to.:•crip!~erai sites 8ut in aerosol scanning hilar dc_usitions wcre not ignored. This hilar deposit:c.ns were duc to iaspaction to several bronchial bifurcaCior.s. : peripheral airways marked deposition occurrcd ,~.y sedimentation. Thcse differences in flepos_tiocn aechanisms were thought quite important in con- sidering pathogenesis of lung cancer and ch:or.ic obstructive lung disease. In aerosol scanr.ir.c, generally performod, this phenomenon was usC1i:} seen, because our ultra-sonic nebulizer proru:ea the aerosols of about 2 micrns. Once airway de- formity occurs.excessive regional spots and Lzst- al decrease were seen. These data showed to be eareful about aerosol therapy,to diseased luna. I
Page 326: wrm95d00
.... - -_ - - ~.. -- ._.., ;~ --~.,.:...._.~.....y. . _ X7CI MeA5-72 • S .P . ~.r.- 50335 2823 '33 Nutr. MetaboL 13: 331-338 (1971) ~- ~ ~~. ,.....,..~~. _ ~rt The Concentrations of Fructose, Glucose and Lactate in the Splanchnic Blood Vessels of Rats Absorbing Fructose 11!i0 and P. A. MAYm Dirision of Biocficmistry, Department of Physiobgy, Royal Yeteritrry College, I lniversitv of London. London A6mact. The concetstn.tions of fructose, glucose and Key Wordr "" bctatc were measured in the hepatic portal vein, hepaEic Fructose absorption t vsin and syatemic aorta of fed and fast3ng rats given a Portal vdn [reetose W6e meal of fructose by gastric intubation. The rnaximum Portal vein lactate Cotreairation of fructose found in portal vein blood was Portal vein gluaose within the range 20-•10 mgJ100 ml. The corresponding Hegatic vein fr;tctoae range in the syst=ic cirptlation was 2-6 mg(100 ml. A Fiepatie vein lactate frnolional titpatt fructose uptaloe of 54.9% and 71.5% Hepatic vein glucose was found in fed antf fastir.r~r~ts~,_t-spx~iv~l~, j,~ttlC frtier~,~,jnte~~al~laeuu. a~ls~aano,,,e,,,,,R 4 5 1 i2 0 5tI0 tt02
Page 327: wrm95d00
L s+sthod for coaputlaQ the residence tt.e of the oelt In the screw channel aad the ..yattwde of the deformation of motion to which the various vol. elements of,ts+e eYte.dable waterial are sebJected was developed stertiap troe a polytropie sstr.sioa aodel. Tt.e resuits obtained are useful for anal. of the saqnitude ot the tizing action ewe..wtered by the polymer passing through the eztrader. - The sdvewtaqes of csaical screw extruders are stressed. 7 rT''o, , ltiXING ACTIaM DURING taYMER [LTRUSION AND WM4DS FOR ITS ANALYTICAL DETERMINATION. V. (USSR). Pl.st. Massv 1969(8), 31- "s'"s'~. ~ The spiral motion ef a selt tn a screw e:truder was {nvestipat.d. 
Page 328: wrm95d00
50335 2844 %I-ReA10 77 INTERNATIONAL CONGRESS ON TOXICOLOGY, S.P. Mar 30-Apr. 2, 1977 - Program and abstracts of papers. osooooxs1 3 3 k
Page 329: wrm95d00
. Ind. Hyg: J. 1961, 354-361 (1961) 6 XXII HeB 7 S.P. .;- : i.. ; DLS., F. OYEN, and V. K. IIOWE, ALS. Biochemical Research Laboratory, Tht Dow Chemical Contjwny, Midland, Michigan Groups of laboratory animals were exposed repeatedly for up to six months to either b0(!, ?00, 100 or 30 ppm vinyl chloride in air. Detectable changes occurred at all but the lowc-st concentration. The results are di.-cus.=ed and handling precautions ;u~ested. kdroduction V INYL chloiide (M=CHC1) is a dutnical of great industrial importance. It is used in the preparation of pol)-vin3-1 chloride ressin, as a eopolymer in saran and other plastics, as a c emi i ter~i:~ *d a oh• t. Re- ~ The following report summarizes the re~,:f of repeated expo~tres of laboratory animal- either 500, 200, 100 or 50 ppm of vinyl chlo-- The siottificance of the rcwlts is diccu~~l . . recommendations for a threshold limit value made. . AAUCR thFltin a't% ~•itll-! cGon . it has ~__-----•-~ e----~----- 1 ...,,~. .....:...... , ......,.~. ~. h b h crn generall} assumctil t iat t e grcatest azar __ The Toxicity of Vinyl -Chld•ide as ]Qetej'Jllii2cc ' by Rclzeated Exposure of Laboratory Animals . fl;-z'
Page 330: wrm95d00
50335 2840 Xcnnedy, Joseph P. POL4'ASSB CMZS'iRY OF SY2U'hETZC ELASTf}f =SRS , Pt. I (S#.Sh Polymer$, A Series of Munographta aa the Ghemistry, Physica and Technfllagy of high Polymeric Substences Vol. 23, Pt. 1), by Joaeph P. Kennecty and Eri.k G. M. Toriaqvist r a 490 Pages Intermcienca Publishers New York 1968 ..,~, _..... ~SO-000.25 -2 9
Page 331: wrm95d00
50335 2839 - - r t *(no affir-.)* PSYCuoLGt;ZC.UL C0:3SIllI' :ATIONS. RJR CLASS NO. PAMPHLET 71 X To %.- x(1t. Conuideraciones psicologicas.)* Nat. Congr. Pneumol. Thoracic Surg., 13th, Symposium Med. Problems Qrigina'ttad by Tobacco, paper, Mexico City (Apr. 1969) (in Spanish with Englisth summary) *Reprint in: Neum.ologic Cirugia Torax 32 (No. 1) 31-4 (Jan.-Feb. 1971)- Pcop/t 5..,.d'e,- / a tY.~de re.i.i~Y *1971 , Np. 21, t; 9212: *d* To'c(: -,edicine~: _, +e+z ._ _..:..6- 5'0 ~ 0 ' 6-0
Page 332: wrm95d00
m Q 210 Ib 1970 ..a,z.....~.:. s. , i_A Ji' 50335 2842 DIC?IONARIES--POLYGLO?--TEClOVLOGY/LANGITAGES--DICTIONASI88/ ---'~ TECHNICAL DIGTIO'irARY TECHNIY-WQRTER BtJCH ~ 4SECTBOSCOPY_ S"P~AL ANALYSIS -- ~ ` Spekfroskopie • Spektralanalyse ZftIi" E"fth EPaW Spanish - . 6ezmn. teusdi Cesky Czech. r 'French Fraogais Palsid Polish kussian_p~oa~t Umgyar Hungarian t-~ - • Irerao9eteben s+oa DipL.ng. Dr. Heiadch Modtz ' _ snd PtoL ~ IA YEB VERH~IB BERLIN MMMMEWIM&CM 0
Page 333: wrm95d00
50335 2831 ~.a-..::. III ~~~ar) Nal Natkaagawa , T. (1968) PRM a MAdM'i'IC RESONANCE SPRGTM3;'i OF PE2#=' NQLECM.Fs.`S SYCHATMII+G BETVr..PI$ SiTRFACTIUaT MIGELLEEZ A1M WATER PFtASE, by T. Nakagawa and K. Tori. Nolloid ?.eitscbr. L.94, 143-147 (1564) 05000025 1 ?,0
Page 334: wrm95d00
S0335 2843 a Cs ~ • (1968) CsuLos, Z. I=P.LPARATIOn AND IhFYESTIGATI4N OF LEWIS-ACID CCcIPLEX,I:S. IV. PP.F.PAP.4TIJM AND I,:: ESTIG.yTIC=x OF THE 'rliANiJif T: TnACF1WFiDE AND TIN TT'TkACHI,Q ;I.P.?i C,'rfPL1,X,ES !'i' TtaE ESTi..:.'ta G.: CYC:.;;a:iX.~'rE I?Ifi:.S :;1D :E'i;~C:.S,~''tFF.Tti.E3$ CP MONO- A.t.D OLIGOSACCI3ASIDES,by Z. Csurors, Gy. Deak, 1. Gyurkovics, S. Holly, M. Elaresa:thy-PaPp, A. Tarok- Ra lraar, and 8. 'Lara-Kaczlan Pcriodica Polytechnica Chem. 1•atS. 12 (?to. 2) 147-159 (1.968)
Page 335: wrm95d00
50335 2646 R,7R CLASS 110. PAISPlILET XI ToB2-77 s.n. , ,,,'1,ithout a word of debate, t Winston-Salem, Totirnal Winston-Salem. Jour. 1977, p. 6 (June 22,1977) (in English) City Council Monday passed a sweeping bytaw which defines the puff - on ci;arette, cigar or pipe- as a prohibited aJc' tivity m-most public places. 1' ~tFM.. ..~,.._awv. w.a :..:s:.. `~ .:.. ~...:.:..e ..r._._._ _~ ...: . .....wr.: . . / 0 5~0.0 0~ 25 1 -3S*
Page 336: wrm95d00
t YTIC/EMISSICfN SPRCTROSC4PY/ Em1SS14n Spectrochemical Analysis ~ D.Sc. a.r..dI .r....... c+..rv . fL ro.ft w..Ml.1.+..... R....4 wr....m w car.rr. - sft+rM vrN.* ar ".Wr.. tr..ue -• . arr.a"aww .r o. r..rr. M.... w ar.... Arsd MU D.Sc. a.r....ra..rw *..".r *r*..,r..+ c+..~rr. U+.rO aa..w x.r..k *.o. ErnA:'Gegai M. sur....e+.t - . Adam Hker, 8cistd Craw Russak, New York
Page 337: wrm95d00
English) - 50335 2d+t5 XL: TQ3S7-78 `r, S. P. ; RJR CLASS NO. PAMPHLET.`I Toronto, Can. . ~ BY-LAW: BANNING OF SMORING IN PUBLIC PLACES. Toronto, Counc. City, By-law No. 398-77, 11 p. (June 20, 1977) (in _ . ~. ' 'hcrraa, it is dcairab{c for thc hcalthh wfcty and K•clfarc of thc inhabitants of ~ , ._ 4 tAc. City of Toronto. to Druhibit or rrF y ulate sm ~n , or 6oth, in Ihc Cit of ; Tor:~nto as in this by-law more i+articularly sct out.~~ -
Page 338: wrm95d00
I 1965 162 gEges Chemica1 Institute of Crxnade, Torcuta SAction
Page 339: wrm95d00
50335 2848 -~` PJR CLASS NO. PPIPNLET 76 XI Re-78 s.p. TTE Ha`.ER Cfi':ADIAtI ATHLETES TURN DDtlN ADVERTISING FUNDS FROM CR'~ADIAr! CIGAP.ETTE . Toronto Star 1978, n.p. (Aug. 5, 1975) - in English . -1e1 Win. . +... . ... il
Page 340: wrm95d00
50335 2837 ~. kj,,~ ' .~ t~,~ ~_ ~.~ (~s~-~ -40mrvM .~~~~ ~ WA&R ONCMA ~+qs. COPOCAL :*"WCru= FJt'ca*A"014 VW 1W MIftA1RT LOWAM FM "WwD1'EM£\T ftlNT=4W rOdUSt1AlFA ~ *a=t1h "ho"•)W s+J-stem Is deseribcd •ats swd relMtins ai~sJaaeey at spectral tiftWOON" 41 tfwse iralnte-. Tcii ti-ish 47 "unkrow•nt•• ~'M- *tMi-e+i " Wle 40 sdditiei"i 14weNtA ~catares bad ap: I. JG1% with aVcrnc
Page 341: wrm95d00
To, 50335 2847 NE1rS f7SU't'M 0i8 Ift ftmT OF op?It*& cAPM 7NSTIWN OF filtLAbA uoac cURE'!"t'E s"Oll" wv us* CAMCUP ~.•'•i 1~' s r ~ ;Q'~ 4c M.. .Ji:-'•:.3: R
Page 342: wrm95d00
50335 2853 0 --r-...,.-..-..,-.,_., x.~....._.: r..."..~--.-.....-,.-.-• . 76 !CI Adl-8~ RJR CLELSS NO. PArIPHLFT 78 XI Adl a9 ; S,p, Toronto, Canada. TOBACCO AI)VERTISI'SC BANNED I*: Tt1?`,p"TTO SIB?JAY, BL`SES. ` Toronto Transit Cot~a., News Release, Toronto, Can., (1979) - in Enolish. ~ *Abstr. in: Progress Against Cancer National Newsletter, 32 (3) (Auttnart, 1979)+~ - c ....L- .-.:.'-4- ,yofn the past few nKmths. wc'vc bcen dciugcd~ with storics about dangcrous tonsumcr prcducts. f•.api+nivc pup bot- tles, bactcria-ladcn Ix,ultry, asbc-uos i Tncd hairdrycrs--tht Gt•rny of haurds a+es on and on. ~ But thcre s a much more scritius hcalth = problcm, one which cuts fivc to cight years from the lire cxpectancicx or 30 per , ctat of ths children in school today. And wc bcar vcry tittk ahrwt it.,. .__.. - . x_....- -- - ----~-~..-..- .:....::.-.,a'.:-i.A~.r ..ic.f..a.::a.......D _...r ;._.'~=... ~ ._. ..... .. . ~aa 0 5~a0 0'2 5 1 4 2
Page 343: wrm95d00
. 50335 2852 Adi-8fl-- S: R.- . . M CLASS 90 - PASRU.ET 76 XI Ad1-80 s.p. Toronto, O+nt., Can. TOaAiCCO AD DAN CCSTLY. English) Toronto Transit Ca..., iievs 3elesse, Toronto, Oat., Can. (1980)(in *Abstr. in: Oshaw Tiaes, p. not given (Aug. 26, 1990)* Toronto Transit'Co.aissioners ha.e taken the fiaal step. They have been taltiag about a ban on saokiqf advertising on TTC property but now that talk has keame a realitT... D 0 9 0 0 0 0 2 ,5 1 4 1
Page 344: wrm95d00
50335 28 51 -_.---- ___-.-.-.----.I --- r.~7vV•n...~°-.ar,-,...,-..~y..,,..f..................~.....r*..s•A-.-.+.. ~ •....~„e.,,,~_ . 1lJR QA.SS NO. PAMPHLET 78 XI Ad-79 S.P. ANGRY AMtEN PROTEST TTC CIGARE~ AD BAN: FEAR OF "DOaIX0" EFFECT. Toronto Transit Cozm.., News Release, Canada (July 20, 1979) - in Engli *Abstr, in: Unidentified Canadian paper, 1979, p. not given, (July 20, 1979)* ,/(pvERTtSERS w•cn "n~i c to look silly" during the rcccu~Ta toato Trancit Comm`ic~Ft' 11 a$ on agarc C because the Snal decision ofthc TTC was ~in all 1ikelihood. pre-'d pued before the p scnsatioa: werc even made." I-- ---- • ';~'f , 4zi/ . I .Y. t~ S 0 0 0 0 2 5 i 40
Page 345: wrm95d00
.p. ,; g.3R CLASS ND. PAMPHLET 11 X Ca-78 s Y ~ ~01TAWA WON'T BAN SMDKING --OFFICIAL •.. Toronto Star, 1978, ~. not fiven jJan. 12, 197$)~fin En~lish) Federal•Realth d€~ar ment o ficiais say Canada.wi 1 con inue to discourage smoking by the voluntary approach rather than through legislation:. / i 50335 2849 I ( i i r i r
Page 346: wrm95d00
. Vd A. oe, ~ 7"yf s7-R R,1&r" PO~2 h Tds RFE , tygtt,VAR ~A Qt~}Ti0 /pRESSaRh/sfkMiviTy~~a + Ot•Va ~',C Fc r~ oy~ c co~~~ o t~,~t.c~r ~ R s~ ~.r r- • 1rE'c / .. f 4z,ECTRa/rrR/4.NJOMe ER /GLOtsISS - r;t +W1tS *ri.wf~i3pt~~E~rs..t~a,rF~rr,,~j~t pwt E EAvow N r,'< 7Y7oHo i94q 0 ~ . RM rxf 4 a s.. / 10 5 0 0 0 0 2 5 1 4 5 HARRY N. NORTON Jet Propulsion l...6o.atory
Page 347: wrm95d00
50335 2857 L'OW13TERS/ QA ~ICP*OP'R,OC'I:BSSORlS 76 New 13irectic»a for .Desfgners 30 .1975 seleow from ,BLECTIIONIC DBSIGN 11.neiNr F.~o.r. i7.efr.~ir~pM~p~~r ~ 1iAll.DEN BOOK CAMPiANY. lI+IG. woct~N. PWV. Nbw .t.rs.y
Page 348: wrm95d00
i 50335 2058 ~ i. ~.... Z`i ~.'a r .W o ETv F~ i(~ .1 .~14drrTa.a.n .~ ~~7Q G.x tlir~jfyT t11 .3~:.LC1:~~C J . Photostat froms Spaia„ Nine Ce Arro Sv;u_ do p_io1'. Pi ~.~ c~ rropa;4 Was Li,~u1;s-,ima:: ~ (to, 18} 1-2, .J1Ma6 (May 1045) ~350t~t1a_25 1:A 7
Page 349: wrm95d00
RJR CLASS N0. PP1?PHLET XX Re3-78 s.p. Beverage kbrid 1973, 22 (June 1978) - in English Mentions Nawaiian Punch.
Page 350: wrm95d00
- - 50335 2864 TA 459 Oh 1974 Archer Rensselacr Pblytechnic Institute, Ph.D., 1974 Engineering, metallurgy University Microfilms. A 7(FiZQ?( Company. Ann Arbor. Michigan ~50000 25 1 5~
Page 351: wrm95d00
zs I s~' -ov0' 0sa pumT:3aag'qSinquTp2 evT330 daP,+aoy3~:.S s,L~as~ isA 602vd OL L96T Ss::.uoud SSId QR+7 HSU 10 NOISYAgSS'3gd amv Jl+ilm'"i~'ri SA.L id0 9961 Z80dS8 'IYON2i°V fiOWSS mir-aS?'d min ca=3:3g qoa*esn Ss.xfly FiSTZ _' MM : 2SU °-14@`-°4Q`IMWRM4 t,W- - MNOWWO" E9fiZ SEEOS
Page 352: wrm95d00
50335 2862 TE)Rm fiwvURtH STATi(X4 AWMAI. R3sP0RT 1966 CH THE HAAIDLIz<G A:`'iD PBESLP.VAxION 0B FSSEI AND F'YSH FR.GD~T~."1'S 1967 70 Pa,g®a Hat Majeaty'a Statiou,:,rq Ottiae Bdinburgh,BcotZead 0- 05© 0 t~ 02 S 1 5 1
Page 353: wrm95d00
50335 2865 DTSSERTATIONS--RUTGERS, THE STATE iTNIVERSITY/CORN--PROCESSIidG/-" MEXICAN FOOD/ ~ ~ 77-25,000 Tp ~ FVIRTJPIEZ, Naria Luisa, 1940- 1 jACTORS AFFECTING TEY.TllRAL BEHAVIOR AND 374 ) VQILCIUM COtITE/!T OF CORt! OURIt1G THE Ma ~ LIME TREATNlEt1T PROCESS. 1977 J Rutgers University The State University of PDDL ~ Ncw+ Jerscy (tlew Brunswick), Ph.D., 1977 ~ Food Technology i ! Xerox University MFcrofilms, Ann Arbor.MKh+o•n 43108
Page 354: wrm95d00
'wuoeW pnaw Pug twq! 91 A Fl*WW4Pq`aaW Asg""q Meq MP jo moqqamoJdos Ap.arlrs ft.pitxrcap epou!lqdxa aq piuo* Wor# tnnMMoftna arp "Une. "aaessa~IqnO PW *Vr taO", .. •vgsuos,rad auq3 alp ue uao spsq t3=.awMs a3 PMM IMP4 :o i3s; upstu IrtuacuuwuAus arzg; pm Aamponq aaAp pm `potAps*-aWrg Ilass.das aaaa., _noif o&t ap yo sw.M aU 'siiad 0*3 asM p tpsa ag paot* ssa pWIMooEMAaa,o Ats# ?=t Amunxw imta sr paArsp st=a pos `Am•wdar P=Ata+i us =m lpta `asop=EL 'Ajwpp" Ap4* .q aa pGOMS srpos ARMalmd ON ' "Sotsos AWBcOM aiTSSedar `t MP jo Avt aeq; amar io; aeW oqs stia ma sU 'ysavodaraa LrMpanq ON ARM"m Mq ,i;luao 1pus,cs s pnt topi3 AWnwand aquos40 m43 puv uqamu pmoo gii to[3 84aoqs snasas aq,y 'ssspioup autWpioq ao *pojms je; palsa4 unq pwq jpd Weo ul aqeil asp jo ano JssaJ IY 'sasA4 paxas-ooass qnyw gm puw aimJ 09Z 3a' "Im*i *aa p."o =aq nq sini#.fW[mariad iwua*AR a.ginduq pscs `a.pm4O'aqamaN tumaaop arss<sPO". aU OM !a Alnusi"?WI 'Agoloya"fiW pmwq u!r qammF/ Jos .4vurJ : xsru, wcwiK ao pw saOwnaS A* owwo 4amou tRAWum sUe-ll ItIlIeuasiad EsOPa;sAN enisindwt Pult `"ssssqt3 `OlIQMN IWOUGO ;o uoIIeRuaJa114Q tejuawu.OJjAU9-ksjSWaH 18-g p~ ~ • oWqWmctv«%Wmv / 'aw 's•n a uqv1umnwt r•vd.w "'^~) v8z tqlw" iWtAE M++J ~Y
Page 355: wrm95d00
1 50335 2859 MEAT FLAVORINGS/FRUIT AND4E6ETASLE FLAVORS/ CHEMICAL TECHNOLOGY REVIEW NO. 155PERFUNES--PATENrS/ PERFUMEs, sxxTHETtC/FLAVORANTS/ MAGRANC.ES r P 983 AND FLAVORS To Ra=tit Deveta*ments f C. . fXft-0 DATA C7OIqORAT1ON . Ir.tlMybM~w'.'wYt~4 ~ ~.,.,..~ti....., ~ .~ ..~_- 4 i
Page 356: wrm95d00
50335 2861 #I!'WT~~tICSlMATHEMATIf&; STATIMQJ STATISTICAL #NALYSIS, QA PRMCIPL,ES AND 276 St PROCEDURES .1980 Robart G. D. sted A Bnome~trical Approach `'Socond Edition
Page 357: wrm95d00
• 50335 2834 OCCUPATIONAL HEALTH/ TOBACCO--SMMI:JG--HEALTEI EFFECT/SMOKI9G AND •HEALTH/ .79 X-Fo cf.AsS trn_ PAmPIfi.ET 79 7C Fo , . . . . , • . . --- ----- - eatral County Hosp:, Falconbridge Nikkelverk A/S:Kristansand, S. Norway, BUZNOSCOPICAL FINDINGS IN NICKEL'WORKERS, WITH SPECIAL EMPHASIS ON THE INFLUENCE OFVVICKEL EXYOSIIRE AND SMOKING HABITS.. Acta Otolaryngol. 88, 279-88 (1979) (in English) ~ - aAeywords: * nickeh_~ured, constitueexaminnt: • . - ~uron. N~tsunci as`socta~ioo'was estabu ' Akstner. Rhnwscopy and X-ray examination were per- • sr'" formed on 318 nickel workers and S7 controls. to study between rhinoscopical Undinss and epithefi:d dyspirsia cancerous 'fixmd by histological examination. Tk exp!•anatory values the siy~ificance of these methods in detectin i t . . and precancerous mucosal changes. The cliniul and for the rhinoscopical find;n~s c(diQernn factors. such as athok~- workinScatea°y• ap• duntion of nickel exposure (• radioiosial fndinss were com ured with histo p p ical data aad mucosal nickel concentrations determintd gramstobaccosmoWpe7wKk• and nickel cwnent ot _:..a_ ..s __._ .. ~ nasal mucosa. were evaluated by apoh•ing a stepwise - N~i~. Nv~/a~ Na.aca~a uVNa aqG a1aNYSt \YaV/aNK• ~ duration of nickel ex;wsure. and with tobacco sawkiK multiple rel;ressiOA nnalysis. Number of years from first S.bits. 77he aidcel-exposed whjects had statisticaNy empbywo at the nickel refarcty awd tobocco consump- es (i3 ez) than t6e ~ tum ve the only exptaaalory uetas that show ed a ~ sijnifaeanaly more athalo ical chaa p e ~ al h e I eoatrols (26%). t0.01 tt<0.~21. mainly due to differences statistics~y si~ndica~ cornehiioe ~ the rhinoccop 1 L~e fn~~ at t........t.c.:r .i.:.;~:. *rt.:.,....a w:.s.1 1 fudints. The radiobBical euatiaatioo revealed few -.-----~ -- --ir_r----._ . ~ charactenstic findu$s. ClteaacaW aualysn of ciQarettes Workers h%) fisd ttssal PdlPs• Twe.af. these..cases. d roltedi drolted by nickel workers showed high nickel concea- _ br+ Dodt employed u the rndcet rdinery Ior 26 yesrs, ap. i • d h i • reues. ~. nate c it noa-contaat ..... _ , peaned to have nasal carcrnoam• aceordier to istoloAieat aatioas c°m w 0 5•0 0 002 5 i2 3
Page 358: wrm95d00
~ xx ~ MeF .a ~1~570) 3 S.P. r R. J. RapaolCa Tobacco Co., Resea,.ch end a rcduct Davalopnent Deps.rweato, Scieace Infot-mat.ioa Div: si.m ID?DaSTYD~t.f. g'i.{''..~3. C 229. STi.P.T.P.S SITCII J4„4 k' c`ZTATCfF4' . PAfi?'A,4;, F'PC o; by fL ~.T o 1R a~ r~ ^i.t.R Tobacco Ca.! Research and PzQduct DeveLo_ment DRpastin.eate, Sciance Infar--at3oa Divizism ~7~u~toa-Sal.aa, Y. 1.].r3cti:,n of a.a.:.-orW c 0 5 0 0 ~ d2 5 1 9 6
Page 359: wrm95d00
50335 2858 2~I T . ) ~ 2 ~ (1968) ~ ~ ~ uWif!rIeT , R. 11. G. S0aCxr_'iET1IGAF. STERZLZZATIaN, by 8. M. C. Bcvcher, H. A. Fisan4, G. Tortora ana E. Uw%.ck3 LF1trasozxics 5, 168-172 (,iuly, 1967)
Page 360: wrm95d00
t Jour. ileurochemls try 36 (2) #47 -A53 ( Feb . 1981) 50355 Zass a_Bungarotoxin, Binding in 4iouse Fly Heads ar, Stephen W. hones, *Puppaia Sudershan, and tRichard D. O'Brien Srrtie,n qj' Nr»r,#he„krxr pnd Krfirtri.+v. Curuetl Unirrrsil,r. 1t4ur-a, R'r a• ),,rR • t:..S.A. 7 . rhrrK r»i. T,.~- - ~ V •/ 36 4d7-4lt2 ( t4tt11 Abstnct: House fly heads contain a*ite that binds a-iwnaarotoxin w•ith high atienity. It is present at about 23 pmohg of heads and binds a-hungarotoain (taheted with I'HJpyridoxamine phosphate) reversibly with a K,, of a n.t. The effects of 18 drugs have heen compared on the a-ttungavotoxin binding .rlr> rf house fly and 7ory.rdu. The pharmacuk%,~ of the house ft} site is similar to that previcwsty repaned for t+euronal a-huni;arutoxin t+inding sites in both vrrte- tmates and invertebrates and is distinguishable from that of the chas%ic nicotinic neuromuscular acetytctxoline receptor. a. e.eml+iified b) that of 7i>r; •, •hr ekc- tnqvlax. Differences between the house !1} site and 74rrpi•.1+j include higher a1'ftnitiea of the 7urlu-du receptor for decamethonium. hexamelhoniutn, carhx- m$lcholi:ne. and acetyi-{i-methylchoiine. but lower affinitiie% firr n;cutine. at- .FC.pine. and "ydro-/3-er!•throidine. Key V1`ords: a-Bungrrutoxir. binding- House fly head n-hung:untoxin hinding-Acetykholine receptor.---tiicotinic receptors-7urpedo electn+plax-7:.ryH•do acetykiu.line reLq%o*. J+mes S. v1. et wi. u-$ungaruti+xir binding in house /t> head% and 7wik•d., electrol+lasx. J.
Page 361: wrm95d00
50335 2672 . 74-__97 ~~ ~ ~CV-IN @or~ a In by Howard R. Maskowitz ref' 1  ed tool for eirl aluaii 11 on o 40 sASTE--zESTIxc! Candy and Snack Industry acceptability, preference 'in product testing ~ 5 0:0 0 0 2 5 ~ 1976, 28-33(1976)
Page 362: wrm95d00
50335 2866 _:. Note on Aflatoxin Decomposition in the Process of Making~~ ' ~ • rr.~ f ~ rom m • - _. : . . . .. v„w tJttivetsity, College Station, Texas 77843 , . , N1. ULLQA-S Sr.A arxi H. W. SCHROEDERi, Gepertrr~ent of Plant Sciencm Texas A&M Zhe aflatoxins, metabolic products of the mold, Aspergirtus flrrncs Link; are highily toxic to a number of animals and might be toxic to man. Decomposition and temoval of aflatoxins from agricultural products has been attemptedz (1,2). Fischbach and Campbell (1) reported that temperatures of 300°C. or above were iequired to decompose aflatoxins. They also reported that aflatoxin extracts treated for a few seconds with 5% sodium hypochloride lost their fluoiescence, and that the reaction products were nontoxic in chick embryo bioassay. Doliear and Gardner2 cooked 700 g. of contaminated meal (30% moisture) in 296 sndium 'hvdrevric#e fnr 9 hT, at iEltl°t' A.flainv:n rnnrentr,t:nn e.roe w:a.....A i~ ~
Page 363: wrm95d00
5*1:s: ;t? 81II1Si NhXER--DESIGN/ 0 ~C~~ ~ ~- ~ ~ ~ ~' ~-• C;h . aractcr~stux of Motet-Effea of t~~cr ~ ~~s ~ad ~ Rcynolds Nttmbem M~~rfit~'"H ead ~~is.,~t.ll~o w1ae~, ~~yl~, ~~yh-.d. If a passivw traaa',iS added to se'l~tyef the ~ele int s,~t sh-~3bs ~~e of d! ia tLe zpa~ftfr rreschmA mixe:, the saot ~e~-s~ pui~o~o~ltrstim Se~u~#io~ui .lqE ecet~t1- I0-a axd' in all aaes the lower bouad is the tracas can be used to domwomm the twifWA-MIN I to Iow than 3 p" &amftm This distsnce it . ` 11Vhiie rt~ the bd+ftos of aMtbaient imuft ca t~ that re4Wred W ertablish fully ct davelopad *micai ~Ompt, e~eta h~Mr b~ewn a~ti~d aa in :~irl- that wer the regioa oI' int~~ELa~ mi~dr-g d+r-icaa;l7evbe ~ a I~qsW I,D t~teil~~ed o~p• F~ w~o ®o~ol. Iieoca, in com. ~ ceatrica4 in a&T$mmse I,.g1. Device MU tolNie, #vSm rr" are notge caDy simiTar, qtw w~ sw .: 0.394-nym LD., cba~ ~~.I~ LD. ~ ~et the app" c76ara ic length to be," d#mak» Device III, ~ to Devi.oe IL 1A 0.81-mm LD., eloaa i~t a e.?4m LD. }~e- w~ce~p+~ g I)evice II (or III w~- # it strnilar to II) with Device IV, the ab~ vice IV, I86 " ii"' cm LD. ~; a artmamb Mronld ad that both devices would br~- 8.1 i Scm LD. p~ ~,V'infittos ~d 'F~, 2.9~i; ~dc, ~1 wl~est s~ia teizes of jet: diameter dam on
Page 364: wrm95d00
50335 2a54 w.._ __ ...._~.._..__. XX Me. - :?-7I1-73 /f:HA.NIGrS IN STIZENO TH & D~~ ~ TILIT~' OF r~L'r ~~IINU":f . , . SHEET AND FOIL AS A. FLz~TC."1 IOhI OF COhIPOSIT'ION* Light Met. Age 31 (1-2)10-12 (1973) . 31. t:. 1)rit:. 1:. S. l:adar, L. S. Tf:is is the dirst of a sAries uf sp cinlly selected frans- Tor. 1. .15. t:op'cr lotions Light Metal Age will publish of Russian orfirles re- T t .o:, 01 alu- lafing fn the light metals ir,dusfry. These frans:efion; on; ore not F.E cspan~kd arplicu: o:,nunum and al+mmr.um iIloys tn a avoilobfe from conver•.tionci trortslation source:,. The subject scricc of nnc- tcc-hnotn-,scal arca- and matter vrill be aimed ot the interests of the readership of Licht the g:eat inrrres: ,-cr•crateJ in thr:c at- MPto( Age. The first orticle of this series is especie!!y relevant A:+,-s for thc crczrinn ni crun;;xr,itc ma- to the aluminum shect and foil rolling industry. The principal tx•r,al5 nccc-ita;c: rr<carih ..ori: nn the author, M. E. Drits, is an expert in the Soviet Union on the trropcrtics of alutninum clercts ur thin stctions and foil in partiailar. subject of aluminum foil and i:s properties. For example, there are iadieations in the lit-rature thi: the n:ecl:anica1 prop• ntm (0•0039z to 0•(irSR in) the gage crtics of foil differ ci;niiicwntlv Ironr lengths u•erc deterntined from the fo1- tlr- properties of maucrials oi the same lowing forn-ula cemp~ition in thiclcr scctionst,-s>. Nott-cvcr, a s}st~zrri; c;uc!Y of this c2- kct has nor Lccn bc•ccoiorr conductcd.-, -Ilte nur rx-c of thc r.-c>rnr trnrk was t!o drtrrmine 3itc crtiic3; t?ricCnesc Gf 1 tnatrri:.1 at which ~.;:.;inct ch:n r cK- lo=I1.3(A )-3. (2) Fnr a spc:imen width of b= 6 mm (0.236 in) the gage length is la = ll..i(Cx)~. For pnr;xi~cs cf coatParn.rg the crst ~ ~ - .~u!tc c;tn~ fLn~:~,ta: ? ..•,t -) ,:1 thc 0 5© 0 0 0 2 51 4 3
Page 365: wrm95d00
50335 2879 Chapter 1. ° I Spaehe, Ceorge D. SP3 The art of efficient readin~. Chapter '. The Total act of reading, by George D. Spache and Paul Conrad Bera. 0 4 5 n.0 n 0,2 5 1 6 8
Page 366: wrm95d00
50335 2874 x.~.~.~ RD HANAGEMENT--Pi.ANNING/' P 69 Ca INDUSTRTAI. MANAGEME.~IT/ 1973 . 2 C. i RSODINEL--MANAGEMF.NT/ _EXECUTIVES/ MANAl.dEl..e.ENTBY OBJECTIVES APPLICATIONS .iND RESEARCH STEPHEN J. CARROLL, JR. Dcpartment of Business Administration University of Maryland Department of Management Michigan State University THE MACMILLAN COMPANY. NEW YORK COLLIER-MACMILLAN LIMITED, LONDON TI I
Page 367: wrm95d00
STIDIES ON CONTINt'OL'S ENZYME REACTIOT'S L SCREEIN2NG OF CARRIERS FOR PREPARATION OF IVATER-IRSOLLBLE A'~iINOACYLASE* TAKAO MORI, NORIko FCSE AND ICI•IIRO CHIBATA (Dept. of AQpI. Bioclun:., Chisn. Res. Lab.. Tanabe Seiyaku Co. Ltd., Kasliima- cko, Hi;ashiwido€aica-krr, Osaka. Japan) (.a-itL 2 5gs.) (16--V-2966) • Introd'nctiaa GeneraIlr, er~-me reactions have been ca.n ied out in batch process b;~ inct:bating a solu:ion containing substrates and soluble enz;znes; and "these procedures caused many disadvantages in application of enzyme reactions for industria2 purposes. If stable a-ater- iaso;u3le enn:*ie preparations possessing speci.5c catah-tic activity can be ea~sircj.ared.rmast of the disadvzrntages inherent in the
Page 368: wrm95d00
50335 2882 ;X ~ MeA Dontenc.-i.11 P W. EXPEF,Lti%1 c,'~ 5Tj.'llIES ON W•f0RIC::C;IC '.CTIV?TY 0F CAr-":.:.•:TTE SDi(3KE CJN?WtdSATE C?.; THE S::Itt 0.~ -"iifi MCrTUSP. LRt: 2nc:; 3rd Reports 1970 3 Reports o~ o o c~ 0 2 5 1 71
Page 369: wrm95d00
50335 2673 € 72 VI Re-76 ~ RJ,B CLASS NO. PAMPHLET 72 VI Re-76 s.p. ~. S.g. ldicevska, X.; Jordanuvska, V.: *(no af f il) a PRESENCE OF SEVERAL TRACE ELEMENTS IN TOBACCO OF THE.VARIETY VIRCINIJA. . God. Zb. Prir. Mat. Fak. IIniv. Skopje, Hat., Fiz. Hem. 24, 89-91 (1974) . ~ : a Yugoslavia with English abstract) - .'aKeyvordaiR capper, cured, constituent; ` o constituent: cured cobalt ;: ;: ; ~ , 1 , .;, ,; ~ : ..; ; ; ; . - cured constituent manaanesea,. , 55986q Presence of several trace clcments in tobacco of variety Vircinija. Micevska. M.; Jordanovska, V.; Tosev , ? D. (Yugoslavia). God. Zb., Prir.-Mat. Fak. Univ., Skopje, Mat• , % Ss. Hem. 1974, 24, 89-91 (Macedonian). The Cu, Co, and ;:~ :' Mn eoacnss in Vir ginia tobacco rown on d vi l il i th 4 g e u an so s n e • Prilo6 reEion of Yueoslavia were 2(F-50. 0-2S-O-E2 and 9.5-140 I 6. reap. T. Ordentlich os0 ©0 0 2 S
Page 370: wrm95d00
I S0335 2es1 i v1 M6lRiT21F ~ - -ele*f"TTE Morrcll, FrEnrciF A. IpApfvR-W" A TOTAL CC~MUSTION PRODUCT CZG:`' _7'T":`:• S''-'0RJi:^ MAChINE - A;r`ALTSIS OF RAIlIGACTIVZ CIGiz..:~s^~I'E : PAPER by Francf$ A. Morrell Pnd Charles Varsul (to Philip Morris Incorporated) To be published in: Tobacco Science 0 5 0 -0 tl 0 ,.2 5 1-7 0
Page 371: wrm95d00
Rkg~i +®9""Eeett @tt9Y0 C. PA\TALEOi•1I (o) e L. ZOCCOLILLO (b) / Summary (Toxicity of the alipliatic aloaeRated hydrocarbons contui- ning fluorine). - The 4uorinatel hropellers have a certain cardiotoxicity. They cause disturbances to the intraventricu2ar conduction, to the inotro- pisme and to the arterial pressure. Such disturbances show up in the laborato- ry rat due to a concentration in the air that once .vas thouaht innocuous for this specie. We have analysed doses of 15 % - 30 % - 60 % of CC1:F.. in the air on the tracheotomysed and curarisec'. animals. The vaootomy protects in part from the occurence of marked alterations ECG, but not from the alterations III Du2-78 S.P. - r o t ~e/~a r~n~~1=1c. 2 5 ~ b 5 ~~' .. . \/i •7ro .-..... ............ w•i141n1 nCr averC __--- 11 f 1 a of the cardiac mechania ain and of the arterial pressure. The arterial pressure is the eardiucirculatory parameter which remains inhibited lonacr when the animal is again breathing air ~~ithnut Freon. After• breathina air without Freon for ten minutes, rats suIjmittcd to,a'succrssive dose of gas are rapidly intoxicated. Low doses of CCI_'I': in the air (5° o) maoe rabbits iperscnsitivc to the a arythmies-producina» efl'ects
Page 372: wrm95d00
50335 2a83 yS08 ACGJ. S~~a~gnt g:. L~ T{Yrf,L HF'.~Air'E AND M€3?V'DL fJ:ri.XCi'ZVhS OP 20BACCrJp by ro Lo StCc'sman, F!; P« B:l.inrfl:y+r and A, pa 5-:4sfno (Uo S. Do?LQ Aar~, A&r. ftcs, Servoy ARS 73-34) Dec. 1962 12 po WasE3iit ;tQn Q 5~.~f 0 0-. 2 5 1 =7 2
Page 373: wrm95d00
I I5. ~ 73 1 Caraiol. Prat. 22(6)G55-S7 (1971) CARDIAC E.ND SYSTEMIC TOXIC ACTION OF AEROSOL PROPELLANT AGENTS. ~ M M& ~t~~'#~t ~.~~~.a~ 1 gas fluoroalcani (cio6 i derivati fluorurati iegli idrocarburi a forte capacita compres- siwa, tipo metano, butano, ecc.) in uso come pxopelienti per gli aerosol, sono risultati sperimentalmente assai tossici per il cuore 0134 topi da iaboratorio (J.A.M.A., 214, 81, t970) sensibiiizzandoii a qualunque condi- zfone di ipossia. Gli cffetti cardiologici ri- ` " scorrtrati furono di marcata brac(icardia sinu- ssle, oppure al contrario di tachiaritmia, oppure di blocco A-V semrlice, talvolta di dissociazione A-V, infine si notarono anche plLu a~ ra~ ni d~ei rec uperi. La sensibilizzazione sul mipcardio fu rapida, talora rapidissima, duratura e letale. Cio accadde anche ai ratti e ai cani. Si pensa che questi propellenti possiedano una capacita cardiotossica capace di nuo- cere a piiu specie animali e anche ali'uomo, provocando bradi-aritmie, tachi-aritmie, ma soprattutto una grave depressione del mio- caraio di lavoro, che si estrinsecherebbe elct- tricamente attraverso una sofferenza specifl- ca del miocardio di conduzione. Sull'uomo la tossicita cardiotropa di questi propellenti aerosolici si rivela in particotare nelle con- dizioni concomitanti d'ipossia lieve o mar- .
Page 374: wrm95d00
50335 2080 VTTT I b~1$~ -~~"~~~~2~ . Prk". , ~ear--Leading ~rands pCoi ~ + } 2 bn 4 ' q~ p.., ~3 ~ A ...4 ~. `.`-,.p ~.! P CZ~S~(C~•. .h 4~ C/Z.i~i :~` :~` ~C. i~.iGL:.:~ r~.. X~-53Z6.. 57, 5s.'•. ' rs. ~.~. ...•~ _~.. 0 S 0 0 n 0 2 5 1 6 9
Page 375: wrm95d00
50335 2889 ~ QA ~ 276 ~ Fe Feigenbaum, Armand Vallin. Total quality control: engineering and management; the technical and managerial field for improving product qual- ity, including its reliability, and for reducing operating costs and losses. New York, McGraw-Hill, 1961. 627 p. illus. 24 cm. First published In 1951 nnder title: Quality control. 1. Quality control, i. Title. TSI5a.(,1,3F4 1961 _ 658.b62 01-11051 Ilbrnry of Congress ..__ ..... _._. __, . . _ _ ._,,..~.,,..... „ ., ...,_..,..,. ,_ ,,.. ~.. _'a°,~.A3-- , .. _ .. .. . . . , . . 0 5 ~ C1 ._J 0 2 .7 1 78
Page 376: wrm95d00
50335 2877 ~ ~'4 ritiV.S.~~~ .~l S -~r:;:.~ ~?j'~^~ ~•,{,a Hy4~ ~ a .. T'~.IetJA i ~,..; A.~~ °4 ' •14v~ ^s-~ y, ~ ~~A~ L,~~ ;~ YR" +:Ll •is~ t~Ztp ; • ` ^ ~ ~,.ss,=; _,~; ~ . ., . „ b.l -:)Y," +J CIL33„l i~J vTC,s`,l sc"lenti=~ S ca Q;~Fa 'S, ~A'~~+/~•s r~ ~ ~~~T TT•-.._ _ ~:_~. ...;(~.~ ~ Yr~ 1 r • • , SJ Tt-M• ~: Y- •`~~" ^~ n~' ~ Z:.f ~•~"J+l.^Lt'~.r. ~'~S'.9r .--_.,..,.-, ~ 5 Q 0 0 0,2 5 1 -6 6
Page 377: wrm95d00
50335 2887 nr.T T OTAT~ Rilil~. r'1'.i ;3~J TOTAL aT'.,i,OLS IId it..~. :m_ IC '- . TL+ ~°?Li.LZY T08ACuv GRisTSS. Stedman, R. L. COT•uCSITIO?3 STUDIES 0?d TOBACCO. X. TOTkL PAi~E1FFIi::= AND TOTAL STEROLS IN RELATION TO BM LEY TOBACCO GRh!:ES, by R. L. Stedman and W. RusaniwsY.yj i Reprinted from: Toba cco (U. S. ) 1 0(No. 5) 52-53 in: (Tobacco Science 4, 17-18) (January 29, 1960) 4 5 a Q t1 0 2 5 ~7 6
Page 378: wrm95d00
50335 2879 i Xl - -- _ -- --~_ ._ ~ i os: ~. ~r J.~. G~ rj I!! I ` - (A •t~,+.-^rR"~'•TMF-n r iz th6 ( '~ te.?w'~,~,h•yE,yO f'!4'.^tLJ,~,!tin~ r g~ ~.. 'i t.:~Q W1 tt: ~N -, `:3.l t C'f VF) a .c;co in ~: . ~ :., , - - : • , ..i.. C j3 T,'~^3 11 4i i~. .°~t( ~'+' ~ l r, f~h ~ r. rnr K~ .T ~ Gis r;
Page 379: wrm95d00
STG`DIES O'_C CO\TItU-O1'S E1ZSNfE REACTTONS VIZ. ACTIIATIO1 OF W3T£i2-I\`OLL`LiE XMI1OACS'3,ASE BY PRaTEI1 DE-NATCRING AGENTS vrsl~twAF-Tmw, T+Kko'_~ioRi s---n IcsLRo CsMArs --T (Drpt. of _9pplird Bsoclum., CFrm. Rss. •LaL.. Taaobc Se%rsk. Co.. Ild,. Washima-caa, Hr;asiri}-odogaavo-ksr, Osoka, jap.u) (vrith 6 5gs.) ~r--xV-ls7oj Intmaucti«n h act-Iase was acUi. ated tn- urea. In this pre.centation, the activation In previous paper%- of this series, the authois reported that the continuous optical re.solution of acyl-nz-amino acids became possible by using a column packed .riih K-ater-insoluble aminoacrlase (E.C. 3.3.1.3-f)1-4, as well results of an investigation on the enztimnat- ic properties of water-insoluble aminoact-lase$• 6. In the course of these experiments, it was found that t;Iie x-ater-2nsoluble amino- «'ater i:vcolubIe arn:nca-rIasA br protein denaturhag agents such - .,•--------_ ~~0 0 '00 2 5 ~ 60 _Sp
Page 380: wrm95d00
50335 2888 TS 2240 U m~'i' CF rIANT: :Sy 1i;. ~A4-~~;~. .STW ,Z;lT - . a.bot"s jNSIXIC,/1a6 ?.r. .. . . ~. _ » .... : i-~. . ~~ .. a ..~ . .... tJ Y.: l:. ~.. .. . w. w. ,d Takarslcccsa.. n ar J(uz; . .~,..,• 0 5 o Q ll 0 2 5 1 /3
Page 381: wrm95d00
79 III To. 50335 2632 + NoTE S, I , tau.aiar or tM caiMrcw:L os ,~wriix, .+ot.. 32 j tt33-- ~~~J91 f. Ue Cron-Aldol Reaction of 3-Alkoxy-?.-eyelohexen-I with a,P-Enals. A Synthesis of 4-(#rans-~Buten~ylidene) 3,a,-tri.meEhyl-;clohexen-l~-ones ~ Tsuwm IxoxucKu, and Hidenori Oo,.wk Dr~rib~t ~ Jwr~4L*Y. StAsl ef Qk9um tliaar~, Tswiirs., Q+Eqrs+Na 700 » (Rooeived netaber_,S, 1978) itaop.i.. T6e eso.aaw resetioa af 3dlooreY4- The treatment ofaldm/tr,vir. mixturc of 2a(R1=h3e, CYelohacto-1-onas witk a,/t-srials aS'orded the aor"SporXW6 Rs=Ei, &xm-HC6CMMe) with saethancsulfonyl NaAaoMr.6-{l-hYdr0Xf"?-a*eRWW. ar7*ti-cydohCxc*-l-MW dtiojide in pyr;udine at 0`!E for I h, and subscquen! i 7b--96 % Yielc3s. The CoQ&MMdea of a linede eMhoe beWmg at 45-W''C flae 2 h, afforded the dehydrated aetioa of 3-aboxy~ 1-oue with aamr- pvaduct 3 in an SM yW. The reaction of the enottr R bwwal, aAd snba-4-aque,nt dshvdmt'm mg et>tar wuh msetlpjrL- lioa, sRaesied 4.(amrt~Z•b~aaylideae}-li,S,S~aaetihl~-afda 3+ wtihoui iqoolatiitg tii~t ~`icat isomtr at the C~ ptrbay, r~th adekhyitith~an at 0'G in ether, follavvn lraoes-I-aoes, oae of the mo~,c ~ of ~°~ stirring at q a aan tenpavAur+e foc l h, gave a mixtttt tob.ooo 5evetw. is< a T4% yieid. ; "aad 4bin an.UThe gsnssabundancz + iupd 04 ~wn intimattd fcom the heigb vaylogo~s a~s ~awre ~tly b +t ~wa~e~y ~+ sMM of the awa.&W cdanian of sad. *F%e sMC 1"i'MI skOr&U sR the C-lt1 methyl grau aDnuos4M with a~ EV348 the ratio et 7 to #, end ethar. U.'t~iat parer, wt W-A their reactions . `'a hs~c found tiwut-Ahe x~ctioa of the kinetic et~oL ithi ~ l d h i ' w ctr a s : +comp 1 W%W -,~,rzia wlth SItc ~+ctx ,~+ct ~ ~x t*rsrs sW sj4eA as =um oI widl af ttfe ~io4+~if4=~a1-2-6~roea~~idra~~) i,5r;- ,=b=W at -?$ "+G wthag the me of a chelati ZAN ,A ~t~ucte~titcic ~ _ . Wis r~aw1 ble tr wwue that the decan ' ,oars , ~ c ° ~ ' L ~ , , '~ 'ios'M ~~ .«.,... ~~ ~ ~ ~S~P~ aod T
Page 382: wrm95d00
t 50335 2886 LANRENCE LIVERMORE LABORATORY arreraityaf cairorrYa. - tmemxre, CatiJomia : 94550 Distribution Category UC-11 II KeAl-79 S.P. UCRL-52473 J. E. Lovllt, T. J. Sullivan, R. L. Weichel, J. S. Ellis, J. G. Huebel, J. A. Korver, P. P. Weidhaas, and F. A. Phelps May 25, 1978 IF 9
Page 383: wrm95d00
50335 3885 " K"A CR-135376 4. rdk aW subc+al III Du -71 S.P. 2 . lluthoris) 'Frederidk A. Haaser and Bach Sellers a .r.td.miq orvni.aMe n wme and Addnm Pa=metrics, Tac. 221 Crescent Street WaNltam, l~dassachusttts 02154 12. Spoeoorwi AVMV Mrar and Addnr Natfocal Aeronautics and Space Admiasstratioa Wssbing#oa, S.C. 20646 s. Report Date October 1977 Ierfo.min9 F)ry.nis,tion Code •. Performinq Organintion Report No_ PANA-UVS-9 10. Work Unit No. tt. conuect o. Grant No. MA83-20472 13. Type of Report and Period Care.aQ Contractor Report 14. Spontorinp Agency Code 16. fuOpMwmentary Mob+ Flaai report. _.Proje+c:# Manager, Daniel C. Briehl. Alrbreathing JWgiaes Division, NASA Lewis RMIattedi Cents:', °Clerelawd, 0" 44135 spectrophotometer {'W* fabricated for aircraft use on the DO FAP inijwMadls ' un a mltotodiode and was flown on the NASA Latitude Survey fiidtts in the -UU ot t~6.~.:~9netlse eallbrathm of the UVS results In an estimated *3 percent absolute accurar
Page 384: wrm95d00
50335 2892 _ OXYGEN COMPOUNDS, RING--NATL'RALLY OCCURRING/CHEMISTRY, ORGANIC--SYNTHESIS/ SYNTHESIS, ORGANIC/CARBOHYDRATESs-SYNTHESIS/PROS-TAGI,ANDINS/._ANTIBIOTICSI- f--";'pIGMENTS--SYNTHESIS/PYRROLES'ANu TIERIVATIVES/NUCLEIC ACIDS--SYNTHESIS/ QD I VOLUME 1 ~ ~ 261 ~ 1973 PDDL Dsgurtmewt of Clutaistry Carlttoa L'Airersity, OttaNa «TLEY-II\TERSCIENCE, a Division of John Wiley & Sons, Inc. New York • London - Sydney • Toronto , r C
Page 385: wrm95d00
' Translation ! ~..~~+.. TE2TAI. 13F. sQi~i Dietrich, P. TGTAL S`'NM'ESIS OF P.BREINOLIDE RACEN.IC AND OF SOME OF ITSS DERIVATIVES, by P. Dietrich and E. Lederer. Tr~anslation from: Helvetica Chemica Acta 15 1148 (1952). r U 5 fl.fl n 0 2 5 i8tl
Page 386: wrm95d00
=4 50335 2895 1456 u ..eF-**A-73 o- Amer. Dairy Res. 34(11)22,48-51 (1972) ,. - . ey D. K. EANDLER Life begins at 40--bacterial 1ife, that is, begins at 40'F. And the only sure way to keep milk fresh is to achieve ,"HOW LONG SHOULD MILK T:EEP?" THIS IS A FRE- quent question from both processors and consumers. Without a complete analysis of the situation, there is only one honest way to answer that question - "it_ depends." It depends on thc initial quality; it depends on the care in processing; and, above all, it depends on the temperatures of storage. If you want to predict the shelf life of your milk and milk products you have to be "temperature wise." Now, there is a convenient way to check on this part of your operation. 0 0 0 2 5 I sufficient growth tor ttavorAmpQirment takes p1af,E in only 24 hours. As a general rule, every 5'F. rise in temperature above 40'F. will reduce shelf life by 50 per cent. If you normally get a 14-day shelf life at 40'F., storage tem- peratures of 45'F. will reduce. this to only seven days. Following this rule further, you should expect about 3-1/3 days at 50'F: and no more than a day at 60'F. It is obvious that these elevated temperatures must be avoided if we are to keep our customers happy. 8 4
Page 387: wrm95d00
~ 71 VII Re -74 RJR CLASS NO. PrL~HLET 71 yPIT Rel-74 S.P. P"owell Manufacturing Company, Incorporated, Bennettsville, S. C., U. S. - -~ ;.. Powell Manuf. Co., Inc., Bennettsville, S. C., 19 p. (1974) (in Baglish) -r
Page 388: wrm95d00
50335 2870 ., ;~i.ztVe--TA s`. . $FUDXF-S ON CflI1"I'I1"tiOt?S ENZ1?.SE REACTIOtiS 11. pREPARATION OF DE ~, E-CELLL'LOSE-AMLN04C1'L4SE ; GOLL~ AND CO\IZ\ L' Oli S OP"I'I C.AI. RESOLL"TIO2: OF r ACETYL-DZr1dETHION-I2%'E' Br F~'zy/no%q. TAswo ~io~u, ICopuo F/usE ~cn/Ics~o C~are (DqW. of AM. BioxF.e+.m-. CAnn. Ras. Lab., TaeaLc SeiyalEr Co. IJd, Saslainui- tJso, HiSasxiro~o~arua-kx, Osaka, jaldax) - c.*tb 6fiCL3 (.16-Y-1966) Introdac#ian To carrr out continuous optical resolution of acyl-DL-amino acids br r.ing coramns tacied with insoluble mold aminoacvlase, scftening of cxrriers s4i-.taie for prcnaration of vrafer insoluble compi-xes ~~.air.zaaact :asr_ tr tc-as performed_ I2 was found that vra;ez-iasoi~Uk zcr.:naa~:a4e corn?lexes a-ere obtained b~ ~i~a mid azr:r~•iz~e to i:4si~ cie:i.-a~res of po.~ ~ax:zarides, ,,~,~C ~'~ i rse~E CT: OLA-ceiirlose and ';~ ,
Page 389: wrm95d00
+Ras. 1P«. 1idt. Yd t!. 6edai. pp. 1l6-t7i. OawrTRllV..o. Aas Lt. iNO. hi*ad 1. ds 1rYi. ~~ II Me5 81 s.,p. _ Albert GoetLk• and ICatlllGint Krauth•• twho 1.nrdeA.natjkr Was" ndrtacin qft, 1UAnchq, - F.1t. OWNWj ~'Ins~t~rt~ttr &WftaWWqWWbay. Weavrole. iqd •i¢j&**UdW% UnlvwsirAr ,StirtQWt Stw4wt RR. Ga,r rrq, ilRSTFAM.. Urban stos' "YOt+it is one of the aajar non-point pollution sources. The "sdltisg impacts os surface waters were gradually recoiais.ed. For decisions on handling storm runoff it is very iqportaet to %a+re iell iniorwatioa about storm water quality. Ia tba~',i iris""3T~s o#` pjevious investigations on storm water po''jlut},pn.,arg snqsarised and tbe considerations and con- clasions ia regard to sa-a--~- -~ _......~~_~...~_ .---~---~ _.[d 3
Page 390: wrm95d00
50335 2893 STEROIDS /CHEMISTItY, ORGAbIIC--SYNTHESIS / ROBERT T. BLICKENSTAFF uedlont Ae.rwreh LJwoeoy vsl.aww Ad..udW.Nir,s xw.nted .w D"u,bwad .N s:d~e~w.p twa=w vaw.,:y, sdwd d udkh.. 1"d.,,wsrn. ,ftu... ANIL C: GIIOSR Slwdww t=tkrtc wd Slwqu Aauwida (SISA) cwwwi4r. Al.ur'MaQts COItDON C. *OLF u..d/od Broa.edk L.6utiM.y v.teim AdM6.Moadiow t/aepie.l rA q pi, rmai... This is Vdume 30 of IC CHEMISTRY ~~~~c[ monognPhs F,ftocs: ALFRED T. BLOMQUIST and HARRY WASSERMAN - --- ---~ ACADEa11C P'HF.SS New York and bxxion 1974 AS.J.ud.rry./ Ilar..ww Aewv Jnr~rnnrkh. PrLJiJM ~ ,:. t~ ~'a'J~ .
Page 391: wrm95d00
Apr 78 YBRFOR#lBR: National Center for Health Statistics, - ~iH~ 1 -~2v, ~DHWlPVSIPBS-7s-1 s52 Librarf of Congress catalog card no. T8-13300. 3eraa cholesterol valaes of adults 18-?4 fears of age in the United States, 1971-74, are presented and discussed by age, sex, and race and are also ooapared vith serum cholesterol raltses of adults of similar ages ia the United States, 1960-62. tEZb"GHD3: *Cholesterol., *Health statistics. Available from the tatipnal Technical infor.ation Service, Sprin;afisid, Iso "161 PRICH COM ' `?C L03j!!P /101 0 S0 ~pB0 2 9 1 7 9
Page 392: wrm95d00
XT To9 -~ VaC1.,.Ni'V [: ~/~~T ~~!~S~'{ .:LS11ii}.V F'L'ia71I ~(~1~7[1 S7 ~ `StSL1Sl~U1l1t:L1JY Cs7cp. Cs$ SC1.onea L (DAe 1) 20-15 (I96^)
Page 393: wrm95d00
50335 2906 Bl1DIATION--BIOLOGICAL EFFF.CT/CANCER--CAUSATION BY RADIATION/ SQ II To THE SPONTANEOUS CANCER MORTALITY RATE AND ITS RELATIONSHIP TO SPECIFIC ENERGY CONSUMPTION June 1979 Institute for Energy Analysis, Oak Ridge Associated Universite#s Oak Ridge, Tenn. v s: t
Page 394: wrm95d00
50335 2898 ~ IX To ~0 -16 . A B01iA.i;zrVS'I' SZ1kB?.D liriCTTIiil~.~~fikL:MOL. (The free {orrl bat:2d } nicotiae ccutezzt of tobacco mL-olre (f'rom kuo.,,;arien tob:ccoz)q) I'ihotostat f`rca: Rioer].etuvi Ko2Ieme..~yck l3, 5zo-~3 (1908) 0 ~,;. .. _ ..z,.,..~ 0~ fl Q t1 42 S 1 8 7
Page 395: wrm95d00
- Packaging is continuing to receive hcad-on attention from consum- ers, em•ironmzntalists, government and manuCacturtrs. The theme is the same for each group - packar ng should conform to certain written and unw•ritten requirements spcci- fied by each seRment of society. Well never _art away from "the all thin_s to all ptople" syndrome and we micht as .vtll face this fact. The consumer is worried about paci:af!ing's contribution to in- creased product cost, government 50335 2894 Canadian Packaging 26-(9)33-35: (1973) agencies require packaees to con- form to a multitude of labeling re- quirements, environmentalists are concerned about solid waste aspects, and manufacturers are trying to de- velop packaging systems to bring their products to the consumer at the lowest cost consistent with maximum impact and product pro- tection. Packa,ing goes far beyond the pack of product the consumer buys at her s}tpcrmarket. The earton is only the final clemcnt of a total packaging system and has been de- signed and manufactured with the CIMIADIAN PACKAGING, SEt'TEM6ER, 1973 hig6est degree of technology and experience available from the aianu- faeturer and his packaging su.ppliers. What is a packaging system? The total packaging system considers the effect of many inter-rclatin= elcmcnts, none of which may be considered by itself. Product pro- tection, materials handling, distribu- tion costs, graphics, compliance with Savernment regulations, eco- lo_gieal requirements and consumer needs and wisbes are fundamental key factors in the development of packaging. Any material which Credit: li'. C. (Bill) Christner - _-- , - -- ------ -- - -- ---- ~-- --~.----?. ~-~ .. ~ . _ . 0~0 0 0 0 2 5 1 9 1
Page 396: wrm95d00
50335 2902 ZT #'^ iLCa}~1.iSJliv i iJi;,ti t7y iotc& Rb1.lr Hf'..[.g's.al. (i:::c:C',uGC'k of %iL'G:i.UGr.?ph:CC Iie1trL'IICL' Materials. ) 1959 351 p. T{:ro-fo Y'?.war-arTr_xm F-anYfutrt s.ta Nain 0 0 s o o n 02 s 1 9
Page 397: wrm95d00
50335 2907 COMPUTERS/ APPLIED MATHEMATICS ANI) COMPUTATION, A Series of Monographs, Textbooks, Reference Works Series Editor: Robert Kalaba . 2;~ Pattern Recognition ~~1r~'.es To 1974 Center for lnforniation Rescarch Univer;ity of Plorida, Gair.csville RAFAEI. C. GO\'7.:'tLLZ Department of E-lectrical Enginrering Univcrii;y of Tennessee, Knoxvillc V~+ 1974 / Addison-%'Vcslry Publishing Cornpany Advanced L;oo1: 1'rugram Reading. Mas;aL•hu.rtts London • Arnarrdam • Don %1ill.. Ontariu • Sydncy - To{,y,) 0 5 0 0 0 0 2 5 1~,~b-
Page 398: wrm95d00
,~, 3Gg _- 50995 2699 XX ?leF-D-W-74 OCCURRENCE AND DETERMINATION OF CARCINOGENIC POLYCYCLIC HYDROCARBONS IN MEAT PRODUCTS. By ~` This German article deals with the determination of polycyclic hydrocarbons in meat products. Figure 1 gives the separation scheme. Determination is •made by running the pure polycyclic hydrocarbons over alumina column (p.64). Some analytic.al data given on page 65 deal with various smoking procedure of polycyclic ._content. Lebensmittelchemie und gerichtliche Chernie 28 (1974) 60 L Toth (,NiSx von Pcttenkofe:-!rr;titut dcs Bundesorsundheitsa-nres, Berlin) Sustimmung und Vori:ninaten cancerogcncr pol}'cyc?isci:er Koi~i•.n~:aascrsto,{c in Fi•_isClnvaren l. x?'ir entsichcn die rolycYclischcii Kohfenw•acsers:offe? Die po•:ycrlclischer. Ktrlilenu•as>er::o{fe enrstenen hei der unvotlstand•,ben Ver- I•rcurn:r:g- ;crli: :cr Art ortanischcr Suhstanzcn Sic si:rd ;. is~ tr 6c~,andtci~c ~:i'... -• '- -~ 0 5 0 © 0 0 2 51 8 8
Page 399: wrm95d00
....'::... an(l 6t~'iE'i° Ot t:1e rp$c~nt} s pi,? 0e 6a ty ~Fw r~Y r; c~:a ~ cnd G. Tcruspl o~tited r.? ni°a RC l~-,nTi. p. 1 (^^_t Snteehea pro$d22te:i in 5n;~A`h;' C n:~~ar v. ?:~ Ur r P.. L'°t r`:_n,r nn,, . v "ui iili:, !V?1Y1e5v!i, ~~ -,'P'.,'L,.T'11 ~
Page 400: wrm95d00
50335 2910 QP 431 iia 1972 3 C. PDDL 2 C. ij . ~ - SENSES A::A SENSE ORGA1vS/SIGiIi/t;k°RING/TASTL'/SMLi L/ .w.jkWF:.INAESTEIESIS/VISIONI _ . J HUMAN SIENS..Lr---S Roiand Harper ~tr,~ nn K l~ !!~r`t Ll.Sc., Ph.D.. F.B.Ps.S. 11 ~,f 1L L~ t L~ trverhui,•na S+KSior FrHow, Depa tment of Food Science, L-'~~ fIItNtiURGH AND LONL•Ota Q University of Reading. C4URCNILL LIVINGSTONE 'r'ai~ ua3 3o3 ` 3a~ t 0 g a e n 0 2 5 1 9 9
Page 401: wrm95d00
DOSE RESPONSES TO%CANCEROGENlC ANOMUTAGENIC TREATMENTS ~. = ORAw1EA-rn•i(M) F. J. Finamore AAK RIDGE ASSOCIATED UNlVERSITtES hnstitute for Energy Analysis .P.4.Box117 ;, .Qelc Ridge. Tennassee 37830 .lune )978 This repot is basetl on work performed under Cont'raa EY 79-C-05-0033 between dw U.S, Depastment of fnergy. Division of 8icqnKl'ical und Environmental Research. end Oalr Ridge Associated Universities. , .
Page 402: wrm95d00
~ouey, ueor~e '~` Touey, Ueorge P. and Jlumpower, R. C.: Measurement of the combustion zone.,,, r_4iW:::c? j 0 0~ 0.0 0 02 52 n c
Page 403: wrm95d00
50335 2903 Sa6 Sd. llant Airrtr., 25 (2), 253-265, 1979 !;L1.1"a /ABSORPTION OF ATMOSPH ERIC Ni.OE a Tsuneo MA7swaARu,• Tadakatsu YOVFYAZ`tA,as~~As and~Koji SutuA'rORt•,•'e r ,1~j l 1 /Cbi ~p A Hlttral Ex ~iuttsl S_tXm/Dui_etwto/CbiGn~ 280-03~u~n_ .7 L ' • "I?isAw of f.nrironrnitu4l ft&gr tA'uriosw! lrarpulr for Earirumn ntay f St.rdirsj !49 Yatabr 'lburu~ti !(XI-?! Jo'rtR - , / '~ tf ~ ~j / 78 ~i iba~od J y 1, 19 tA BY PLANTS AN D SO6LS A Quantitative Estimation of Absorbed NO2 ` in Plants by Q' Method / 'Ab nnira- 0 Q Tomato, sunflower and corn plants were grown in culture soiution containing three different conrtntrations of uN-bbcllod KNO, (260 ppm N, 103 ppm N, and 26 pt+m N) as a uitrodrn Atrtri¢nt,-and fwnigatcd with 0.3 ppm NO= for 2 avcks during their tegctativc stag<a. The antount of NO, nitrogen absorbed into the plants was cstimattyd by "ditTu-rrtuti method" " " ipd "i3i'R ntMhod." «uN mcthod" was found to gi%.r more prubabk values than "di(Ti:rcnuc mnhod." According to "'aN method," thc nitr+nEwn dcrid cd from NO, was about 16°; (tonwto), 23`i: (sunikwrr). and 1a:;, 7(col thc incn•a.cYd amount of total nitrogrn in the whol.: ~t~n il~ 10~ipm `V pt~,~ t}uMe t:rvrntat;a incrrased in the 26 ppm N pl~~t. Otf- lcrcncc {n nltroLCn Cl)t111311fJ1i!)I1~[.~.cSlltlifN VI Re9 79 S.P.
Page 404: wrm95d00
TS 2240 T S0335 2913 ran`a ~ t- °_88b`il'`3 ~7]~s6 of L'jr'a%`c3.~t-~T{^ 'F' ` r V4V 13.d1laa~' ~ p. .:~.i cur 16 ' iI»22a `~_' aly
Page 405: wrm95d00
50335 2915 ~.a...., ~Tj~T~~^~+n n~ii7YtS~~. Vr ViFVSKi7IC 7L:..._l'iv t2±y~(~YR t7T'"~7 ~.~ T T"vuGor-'e. a n :. ~____ t... .a. rsE.i a~iiE F`i.7-'r'ti: U)"ITlATNlNG AJSOaMTS by G. P. Touey, R. C. Mtmpmer, J. E. Y.:tefsr, z--u B. J. Sublrtt R. 7. keynoldq Tob. Co., Res. Depz., Conference, uamiuas 27 png;;s, De :p,r _>er 1963. ........ . . -r:-Jf
Page 406: wrm95d00
50335 2921 _ . .. ....~ -.__ .~~. . ....:. :k1IZr"r~.~2 ~ 8 Y31tp1.t SF1er9 , Inc.. iiCawdi`; , l:Ct%t! p Q S ~ 0 00 2 5 2 1 0
Page 407: wrm95d00
50335 2896 TOBACCO--SMOKING--HEALTH EFFECT/ 81 X W iaq J kly,p Iti. Cxtl 62. i:i_'-1n9 8176 MC403 P 152-n E~UR "JE~SPIR OISi~~~~lf1( ~u. ""N NpU d dux. Htl.t.r:KD ~ Aafnrr: The srwlcuyK hi/l.a% ef' an apuic•mx.k/6irally +nne*r" matr.ittl clf :Iwtirut. .rith ~f l y: / L~ ~ c~ i.%'. J~ d r.e~g ~htiiiritTwtY+ilp df !` MIS1t~u. iltlt•rdrn bnwKiiial caeripmpe in tlt,~ ti..rcii,h c•wuu}' ut' 1'19++'ala wrt.~ wud'wvf in drtail. Uw uf 273 brc>at•hiai cacripwmlt prtic•Ll. io thc lu•riud 1cJ71-INY1i,1t".wevr awlker.-cJ6 .ufthr ttattcsaml 31 TS uf the kaf0" lu a runcn.l wnurial 1/l-15 yeala radil•r. tiMti r w a~srG! X wa/e-od:GL fetnak .tnllkt rr yltt ditk.rMrr ia wfi•. is +aaii.Yk•aA}• ai#ruC><•mu.1.H! w.l in fi•nlalrs. `NmvVer. 71%ul' >vl>tqll'r feal.lr painws rLYI' Y11NACIl a/rI this dilii•awV litntI t!M- nlat.vh ia .wtiairaN} aqp/tltct}tx. M»ct}'atiKtN prr-crut d rbr Illaka amh rpitirrmcrid raritlwna yad ,ustali aril Ixrc'aKlar M•rtr fIM/1[!t1 MpClV IATf/911/71 tfll• 10 qlah'r Nllh i[l/YNR'a1TUpNlLY MIYY•IyU1rLt'1'a, itrfiNll[aat NL24•.o( dC 38 IMu"'~ : I1R• 141M/kRIJ( ha1Mt, in /CaiJll9i Y Ith :Nlt'IMw';ilt'//w iU41 q1'R• ttM• li'/IK• 71% in 1lM' &7L:Ilt' pepubtiua ai tbc• rwum 15 .ral-~ rarlirr. S 1 i7 7 ~ ~0 0 0 0 2
Page 408: wrm95d00
~ 0 0 0' 0 5 Q ~. _.. ._. _ , . 0 (xv6t 'ATrf) 6t-8T 'T96Y •=nof •eezev.a •crV0 aTdn,oz •x •a :.T''.IYj)41.iq *N LQ 40k=y}.7 ' ~ • S~itPns$ (996I) i i ZZ6Z SEEOS XX t 1
Page 409: wrm95d00
50335 2912 Y':f.21tt.'~v^ww i;. RAc3rt' C r p 11 MT-Icz c? ?'HSDtIA-MOIN OF A •a V-I lrX iiLYt.~:_vZN-Cy OF CrI:.~' aE Mlalzp 1r Rcabarb C. iA=PO'wqr, no 3ahn E. nefex, am"a Geor6;e P. Tamy. Papcr presantc3 at the Tobacco Ctii=jsts? nqctas~,-ch Caaeranee; 14-hs W2netoaw&%lsma N. C.s C1otcbar 1961 RReprinted 4rA s Trsiaeco ; tt' S. % ,~,tq (.nor 11) 22-e5 {Tabacca Sxe3onc (, ~?.~rca 17, 1r 3 1
Page 410: wrm95d00
50335 2927 F-L ... _. Lw; . . ~,._ . v~...w.i_. __.i > , . . . . 0 ~.I 0 0 \.) 0 2 5 21 6
Page 411: wrm95d00
50335 2923 I I St 7 (1968) ...._.:.~::.:.~ Stacaforct Reaearch Inatitute LONG E1'>NuE PT,AMI2iG SERVICE - IL':SF..i,,RCH PLEPORTS. 1Su4-to date Boalr,lats Fark, Ca3.ifornia ~.<,.~„~. r~,.,...•~...... 0 5 0 0 0 02 5 21 2
Page 412: wrm95d00
RC 49 To 1965 t1978 reprint Fati~ue 50335 2924 in Modern S'o&fy EnITED BY,~~^.Il 7aRaNS.s= Sr JsMa s. lAMaz
Page 413: wrm95d00
50335 2908 QP PERCEPTION, V. I-4/HlMi1N IlIFOWATION PIOCESSIIR, r. tlI11, IX/ ODOR, T. X/ 30 PSYCH~.OGY.IPH~ QLQ6IICAALYIyIO~T X%SIENS~SY~NDISEIISA~TIOtt, WI~ I~»IEtNRflSt~LL,IIVIVIA/ Ca TASTE, Y~II lNEttROFHYSI0L06Y OF S11ELL. V. VIA/ OLFACTION, Y. YIA/YISION, V.III,V HEARIN6, III/BIOPHYSICS OF T TE, Vol. yIA/ TOBACW--TASTE--TESTIN6, V. VIA, NOISE V. IY MPArW V. YIBY.VIB/LM16UAgE i LAf~S, Vol. YII/SPEECH, V.VII/ FLAYOkANTS-- lf EYALUA , V. A! HANDBOOK OF PERCEP77ON, Enrroas: Edward C. Carterette and Morton P. Friedman Deaartment of Psychology ,,"Volume VIII: Perceptual Coding. 1978 *Vokm 1X: Perceptual Pnocessin& 1978 -' Volume 1: Historical and Philosophical Raots of Perccplitu. 1974 D°;v"s'ty of California, Los Angeles ~ Los Angeles, California - Vo}ume Ii: Psyciiophysical Judgment and Measurement. 1974 bVolume IIi : Biology of Perceptual Systems. 1973 ./rVolume IV : Hearing. 1978 AVotume V: Seeing. 1975 , v Volww VIA: ?asting and Smelling. 1978 +"Voiwe VIB: Feeft and Hurtiug.1978 &!Volume VII: LtWage and Speech. 1976 clu=Xs #*w*pUud-Eoology:- 1978- - 0 S 0 0 0 O 3 5 1 9 7
Page 414: wrm95d00
50335 2929 I Ptic:'.3 op* t.q ~ir ~~6 Y ~ •,• .~ I ets • •_5`:Ga'la.1 TwS .~':::t 1 ,.~.}.~t~ %rJ 1'.Iscf~C1J_ t~•S,:? ~ J Ft°.:_~f~ ' ~ IN t ; ,.~„ ~' 1'c;~ ~ i~(~;i. ,11 P~ ~: ~^Y• R~_ j G~=~_~ Co y ~ ~.: &Iae L~s ~2 svu_ .Trs, ~a i~a ~~tLa:I'3C)8 ~ G~e~ vw;wt~t3R T` } • ~`i • D6Y~,,,~e of ~'~.,~, "f71~~Q0 1'tt7, rf.?: '-'.:COst ?SL39 72 p, NC V{r SavFaticJ C':'J..d.f8go Raloigh ~n Q2 5 2~~
Page 415: wrm95d00
79 VI Ka2 xJR CLASS NO. PAMPHLET 79.VI Ka2.,. Perecsen3l, °4 Anal •, Hungary) p ;: -j - CHARACTERISTICS OF THE MICROBIOLOGICAL STATE OF TOBACCO PRODUCTS. ' ~_ r~+'r - Acta Alimeataria 8(lQo._ 1) 13-23 {1979} (ia 8nglish) *1Ceywords z * ¢enicilliua, tobacco;-` additi.c;z Aspergillus, tobacco, additise; *iternaria, tobacco, additive; i between laralucta coukl bu txacwi back to the uwi'd.y, dof the tobaoco Imwd, the 50335 2901 TOBACCO--MYCOTOXINS/Tt?BACCO--MICROBIOLOGY/ adosporium, tobacco,. additive;' Fusarinm, tobacco, additive;;- 't r . . ;;Jer to evalwatc tfwixiicrobiolccical statca[H •ariantubwcool.rtx)uctR W the irlwlo range of thues prwluctx was invcxtigaf~ed.is .liffemncos found ~ t.echnduej apPlicKl and thc physical cbcmiW charactaistiai of @io pruduct. Ttn mtcrol»al containsnation of tlw various tnbaaeo lualucts: oignn.tie:s, ; c3~ta atxl ciswetts andl,pipi t<Axiik:o by noes.philic aerobic cells vaa 106, 10P and ltf~~ ~, raep., with yeast ex;llx et, 10=, lo° and 10=-s I"_. rc~•, with monld eelis { at ltw,'itlstiqssl 109.~, rnx~p. Infrction at t7tis level ~Tid not oavea any ehaW in i t1u sonsorr cuAlitr of thc prcrduct_e \
Page 416: wrm95d00
50335 2917 . - 74 7QIII k-7"For the first time -" 731' , 04"M by F. Weston Storratt r .7 Joar . Met. 10. 404-406 1 a' . .._. ~ COVT[Si[nOOScastint of tough-pitch copper, lont a roal of the nonferrous axtals' industry, is now ast everyday fact at the Perth Amboy, N. J., plant of American Smelting & Refining Co. The integrated Unt for roasting and melting copper cathodes and castint them into cakes up to 25 ft long is capable of handling !be refinery's entire output of 14,500 tons Per Montti. W'jre bars are also being cast, and later tlds year iit is anticipated that billets too wrill come !ro®a the ae+r -it. 7bis k„ af coarse, not the first time that copper Las been e.atinuously cast. Asarco, and other Srazs, have, for asmost 30 years, been casting oxygen-free grades of capper and copper alloy s in high heat-con- ductivity traplute molds. But over 90 pct of the copper consumed in the U. 3& fs touth-piteh cop.: per, containing 0.03 to 0.04 pet p,. At the cqp- pes casting temperatures, the grapbite moYd would :e.et .rith the oxygen contained in the tough pitch Described by some as a breakthrough and by otleers as the first major development in copper refining in 50 years, Asarco's new roasting-meIting-continuotcs-casting unit is, without a doubt, a big step forward in cop- per production. 41,~_ p-v ~ tion, it Is known to be a compressed graphite mold, with thin walls, cooled by water on the exterior. f t I I ,
Page 417: wrm95d00
?aw.nfttj..Wq.Do ErAUUTIM A Fn.ItM IiACFTM, P3tIOR TO I't'S IIMC}DiiCTZ0I9,, by K. D. TCUOsaf3lt 8nd P. Se Stons* North Cw roL.os State Coll.ege Tobsaoa Reprint Series No. 93. Reprintod frmt J. Fa= Eccxn. 42 (No. 2) 241- 51 (1960)
Page 418: wrm95d00
_ _ 50335 3933 tfACHIIV'L OR HkND HAR?ES`I`LriCr TQDAC.^vOY by W. D. Toussaint e:xd D. G. Harwacda Extension Circular No.413. ?%y 1957 11 p. PI. C. Agrice Exter_sion Servkce, Rs? eigh j N. Ce
Page 419: wrm95d00
50335 2932 Chumney, td, T. IIACHIi3E OR HAND MR.VESTIi3G TOBACCO: by W. T. Chumney and W. D. Toussaint June 1957 27 p. N. C. Stato Co1.1.eee, Agricultural Lkperitnent Station, A. E. Informa:.ion Series No. 57. (D ,~.- ._ .._,~....r .,...,..~...,~...... U~ Q ~ ~0 2 5 2?' 1
Page 420: wrm95d00
50335 2925 Et~de des effets sur I'hernoglobine de la pollution atmosphe'rique mr les oxydes d'azote U.I:.R. dc Sicdccine, iaboratoire dc Biochimic, 30 rue i'crdi- nani d Gaidon, 42100 C,int-i:ucnnc, Fr.), C. 1'crier, A. Rattncr, J. Frcy. '01.1.1371_O\_A'111rJ,L'IILI~te(11', 1 SL72)_3_'4-332, 0ca: Dcc. 1976. L. ._ In FrcncL;1?nr., i'r.. Ccr. sums., iilim, rcfs., frurn Tcxt. '"' ~. Ab:orption 1;+cctroscnpy studies K-crc curicd out on LrnrarJobin, • metlrcmox;{obin (5(cthlib), niuic oxidc }hcrnt+~lnbin and -par A. 7DURRET. C. PERTER, A. Rd77NER ef i tr3troMcn dioxidc mrlhcnro1loUin (10,-1lcthltb). T7ris data was then ~ used to anafyu blood samplcs takcn from 3 poups-100 city dwc)frrs, 100 rural da•ellcrs, and 100 nti+rkcrs in a poliutcd industrial cnViroruacnt. ' 17rc polwlations ucrc furtlres dividrd intom smol•crs.a.-J nonsmokrrs. . ' , In every population, thcrc %ccre individuals with 1O,•llb lcvcls well w.ezir®ld of } ;:•;-indirafint; that N fixation is 11 - I—, -,t , Icvei Q S 0 0 0 0-2 5 2_1 4
Page 421: wrm95d00
50335 2928 ; 71 i XI Me MetthArt, irranx M.t7I}F.ifL, ZUR BE'.1lF'.i`xSVOIiIiL•RSAGE ItUR TAWKWAkEN X&CH WIsKLAssEN HTT HILFZ g;R TZET''R::,~`.iii:Ji1G (Mcde3l for Precticticg the Danand for Tobacco Products t.:.ctsrding to Price CstGgary With ttszs Aid o: C:a.culatians iuvaYviug the We of 'I'renct Fs.nctions crith S^acasl. Rc¢eV'ence to Eart cexmany), by FrE.*,x Men,-mr. t, A.udoly-Z+.cb¢ar ms3 .7a:gv,- 1,ve:ds•su..icc: `? , •.; -„~ Ta1.:n» ;, To4• 1 ` ~ .~.. ..w - `ti•s/ .~.C ~ '~_ _!• ~ •.~ .^.y 0 5 0 0 0 0 2 5 2 1 7
Page 422: wrm95d00
D 't. aut, l3r,a0i:S.. Ro C~«:.a2ea IA,R T.ir THE MA^az'ET PFiF:P.iMT.`'..ON OP by !ta G'.arles Brac" -- artci W, L. Tous;sa4ei::.. e, Dept. Agrfc. Econ., Agric. N. C. State CoiFep Econ, Se--!eb to. 98. Febsuatv 1963 32 p, N. C. State Cn, Ilafm Rsla! ;h, F. C.
Page 423: wrm95d00
II. S. ffiaticsxal Acsdeaay of Sciences, Ccmittee on Utilization of Scientific and Sngineering Manpower TOWARD &BTi"'i.R UTILIZATION OF SCIEiTIFIC AND ENGM-M.Iir, TALENT, A PROGRAM FOR ACTION. 1964 153 p. Washington 4 S 0. ~ 0 0 _ 2 50335 2938 I 4F ~I~~~~'Zr UnK10 A=PItWP-M-+** ACA't'-1BN.
Page 424: wrm95d00
50335 2937 s• _ , --- ~-- ~• --_, ..___ .~ ~_ __ .._~c._~ _~_~.. _: s : • , - --=-----w ~~_._ _ __ _. VIII Hal-74 RJR CLASS NO. PAAiPIILET VIII Hal-74 Rauni-Werke. .Korber Ccmpany KG, Hamburg, Ger. liauni-Werke Korber Co., KG., brochure, variously paged, Hamburg, Cer. (Dec. 1973) (in English) *1974, No. 10, W 3979* *d* Toibacco Lai:»fatture: ....w.e.... I
Page 425: wrm95d00
TOBACCO--SMOKING--PUBLIC/ 50335 2942 SMOKING AND THE WORKPLACE 81 X Na A Guide Prepared By THE NATIONAL INTERAGENCY OOUNCI L ON p_.. ._ SMOKING l1NG HEALTH 291 SRQLDfAY 05_ ~ _~ 8 0 i~ Jri ,~ .~ 1 ~'ALL, 1980 A ~ _ _ _ - NEW YORK, NY 1000
Page 426: wrm95d00
50335 2936 -Z-w---sx:•AA-- ICi,°.AZLL r:1C`iCIA?I:s71A OF :~CIi;';Ci: A;.,) TFC.1:.*LtX=i, Vol. 1-15, Sub ject Guide & Re.z6erg Guiae 1971 17 vals. :IcCrav-11i11 .:ool. Co. :;ew York n ~ S0 4 0 0 2 9 225
Page 427: wrm95d00
50335 2939 9 RC ~ 263 B Battista, Orlando A Toward the conquest of cancer. ilst ed.] Philadelphia, Chilton Co., Book Division [1961) 187 p. 21 cm. 1. Cnnc€r. i. Tttle. 81-11725 tal>t•nrr of !'.orgrese itilki6, ~soon 0 2s2 Z 8_
Page 428: wrm95d00
PTOTIMV~. KS?J AEm,; t,R~ a. C., .Tr, $.''w~7 utj~'Pau ~',tz 'r°m nur TQ;tcoo e b '4. `r``0 Jxe 8nd Y. 0 ~ GZIJAVs T©bac-eo Ro cu* prUt serUa Ro..aV F~c~, (rob.'~=~, i~ 0,2 5 2 ;2 4
Page 429: wrm95d00
50335 2941 NYPERTENSION/OBESITY/DIET & DISEASE/CARDIOYASCttLAR DISEASE/ CANCER--CAUSATION BY DIET/ , 0-.,fl0 2 5 2 3 0 Food and Nutrition Board Division of Biological Sciences Assembly of Life Sciences National Research Council NATIONAL ACADEMY OF SCIENCES Washington, D.C. 1980 t 0 .
Page 430: wrm95d00
50335 2934 : .._---_-- ~ ----- - ~_ - ~ XI Fa ~c'~'a E• Co~ .~rd 1+O~t2Fj C!iFi.~1l~G.ts P~'3a2'~' ~ .~3 C(?ASThF, F~' TIMr cco c~.~~:; ~ ~ ~ ~, .. -~;~ c~~.~c~~,:.~>~ ~~ 17 F4 ~c, &a .M c~ G, S, `~~?~~~} , t ar,+ Wp D. ..s:ain;;P No G, Stste Gc13.060. DePta of A~jfYo rav~y~: S..k.:CB d:culLuz~, Eva Yar.ic3 Tn. 7l, 0imatZon Sorz05 140. ~ ~CrV~7Tl~T' .1frj7 boi°th rvctrC2lrza Stat; Cct ~ ~ ra R;~~ ~^~' • v S o 0 0 0 2 5 2~ 3
Page 431: wrm95d00
41, ~ : " ~~esAli , AIMAL MM +cW TACMA XgtS&TWM M MAv: i. W ' ~QuMICr r1M rRM AREA ON OM&TOM ELjcrrEn ,- ilY xmmz.. AI~G~L MJL$B$ ON RIAAND C#LABROUS SKIN OF ~ ~fX1t~i~l~ aii11AlD l~RY~t.Ei~t~ -,_.._...r...~..~_......,.~ C &WUU mad f0assfim mmm%odos Ob!' At* no&stW pubes of ~ ~ md peObC am wm an" il Odw I* uk sAkft ft ~t ett~C ie~io~t t~ fie~o~ propORt~as of diRa~ types O-~ ~, "1r. Awai"wt t.aNW*4 ier.a.m s, sF-aww Ahrra n (rw..r) jammaw'"m ~•.a~~ mmaICl/Qf. So* mmdh~w~ p4m wOrE delIve1ed to dkE btliy+ Wnofdelmd bgr a,aanafaPenPazpe+abc(an047,&?.3.1. or 123 sq: vbrsW. TiME f!vqIIEaCy of &G i,A%-Sar 1!llHi. Ab.olue @rdtm&ttice&oiac.oete mmsured.rtth a. usa6oes were measu+ed wft Me method of displsoamnt amphuxlea naaisz from SO to
Page 432: wrm95d00
50335 2947 ,.1 78 XI Ad-80 S' F. RJR CL.ASS N0. PAMPHLET 78 XI Ad-80 s. p. Reich, lt, B. (U. S. Fed. Trade Caasa,, Policy Planning, Washington, D. C., U. S. ) 3 Univ. Penn. Law Rev. 128 (No. 1) 1-40 (Nov. 1979) (in English) Cigarettes mentioned on page 35. For exasnple, once the Federa! Trad.e ; . L Commission developed a unlform startdard for'nmeasuring the tar and nicotine content of ciprettes. manufacturers of cigarettes u-ith losrer tar and nicotine had an efficient means of comdmsaicatin- their comparative adr: ntage. As a result, manufacturers began to compete ti igatousl} to produce and advertise cigarettes of even ~ lower tar and nicotirne content.=
Page 433: wrm95d00
t 81 III Co . ~ No. 670 (New Zqland) ~ l'ou Pkm siw wwAod aid inp+ediatts a pnorlluce achu&d s*k fat. Swrer s4amtes). Aprrt dbe not,e we an brknatsrt in dw tarsAnas FandfleuiW{1' qtalnte. A toush paste taay be •ria the followift •Qrmipi.- " -f . a6 Jost boil through:-12y4 lbs. Glucose Syrnp 2 ibs. H.P.K.O. Fat Add to tbii:- 2 oZi. - jo0 8~oo0f ~atine Qrt-soakt+d ~± ~j21bs, water : and 61bs. of Cxy" Gum Starch sofdtsoa O,it 61bs. of Gum Arabic sotirtJoa .'tbn, add smdua6y .bft mixing proceeds:- a dry- aux of approat: . Ge lbs. Fine Icifl3 Supr l6ft. Cornflow Add colow andlHvour as reqt". .. ~. .... s 0 9 A A A n 2 9 2 A7' 50335 2918 IVOTJ&-- Total tivater contents must be adjusted to suu the oripmA# `dryness' of the powdered ingredients so as io provide a non-sticky paste which does not 'crumb' .uben squeezed. +Carystal --am or Gum Arabic mtutions should be prepared by dissolving ova tentie beat mixtures of 40 per cent Crystal Gum Starch or t3um Arabic in 60 per cent water. Either may be used as preferred. Oyuat Gum Starch may well be lesr costly. To extrude 9milar yari-c;otoured sticks requires the use of a machine having twin hoppers - one for each colour required - and fkted with separate nozzles for each oolour, one mowtted insFde the other. The paste is_ ,actrutied concurrently via pressure devices to issue from tlae compound aouks 45 a centre Woured pink) surrounded by a casing ("te colour). A machine for the purpose and capable of extruding p.ue rticlcs havta6 up to 3 colours if required, is the •HUTT' colour paste extruding and forming machine. 0
Page 434: wrm95d00
50335 2950 RJR CLASS NO. TEXTBOOK Z 699 La 1978 Lancaster,F. W.;Borko,H. (ed.)j ____._.._,.~._..,w. Library and InforMation 3cience Series, Acadenic Press, Inc..New York, New York 10003.1978. ISN = 3785
Page 435: wrm95d00
CIGARETTES--LESS NAZARDOIlSiTOBACCO--SMOKE--SIOLOGICAL TESTING/ TaBACCO--TARf 75 X fiaa-M . itqwt Na S . Four Skin Painting Bioassays Using Condensate from Experimental Cigarettes
Page 436: wrm95d00
50335 2951 ~P!]T.in 4n Sherbou..e j Julia F TOWARD READIW Cac£m=ZG;3. 1965 238 pp. D. G. Heatlx & Co. Boaton i n
Page 437: wrm95d00
Letter from Westminster 79 X Re-81 S.P. WILLIA.11 RUSSELL The talks on a new voluntary code fisr c*atcttc adcrnising to take the place td the present aRrtvnnnt, which crntc in March, shiadal hc ctaschxicd catly tt+cxt mmth. '!'1u t4.hacrn indu.try is due ao give its rrM pt.rsc to the {'.mvrnmcnt's 1mM+csals made 1+r- f'i+.e tUixtmas ami it Mitdtc as if this tatte minissrrs are prcptnvd to get tough if tlw•y al', tt+.t Wt the tcqumse thcw x•~tt. At the inaurtnal mcctit>X vrhlt the nkl»ctry's rrfirc- -Ts~stis~ct"11tr'"1'+~tt'l~"~ciiitn~. Sucia~t FarkwSwx•r~r~•, A~.ar.~th matic thr t.crnernuknt apntts the intlatattt tn cut its ,[Mlttt a nar ;tratnKttuxral MsdoiK _ ~ , nr tn the - next r'rtnYcjQ, t~r~ to ~!1ft at~ rr!la~alt~al a NOtICt r1lb kab"W ti 7rotecteA by icf tiw R'ttM 17 L/.S part of the packet design. Varied stteganx .ruuld at Icau tk t Apparently it is ready to carry its uout;bncss to titc poir imposing a ban an cit;arcttr a.hcrtisint; except at the r"+ir t~lc.'t his is cw•rtainly a ar.+na n.~,r iat„t~ aatsce. '11tr aira i. to do st+mcthinQ atxtat the way in arhich cicarcKtc manu[actu have cxl+hvitrd qw+rtittt; cwthtts thrnwt{h st"mW,r.hir to Rc i tcknisism ex•>Rttre they arr s4hcr.risc dchur,l--alf tlu~.c han round the caigcz of kMN1+aH gn•tm,l., athlctic trackc, anr. rinks, forinnctanae. 71~ C:~+i~c-rnt~ctttal~uant~ to put a stop t, clndt;c by which a cipucttc rx•kct can a{+l+rar in an adt•c•n i%cr for anahcr kind d prnKhxt alt,ryacthcr as ewtrt uf the set sires• Rnt ttntil there is a ministcr at the ltltSS with the wt atkt the u•it1 to carrr the .tar apina his mlkapxx-atk! I nnt saying that he is nat Mr jrnkin-thing% n ilt prc.hal•ly g much as thcv arc.rith mmm kind af .•n4untary code. 'i•hc indt is quite cc+ntcnt with a diridc and rule arranvcmcnt and tco cn this Ims it .4il1 .++st-..
Page 438: wrm95d00
50335 2944 I ~'a4 b uy&Ma-, a. 3"z 06 ~ 2'C1',?t;P,A A LESS SAC,,S3L CZtzARETn`S, bWorlkahap Halcf at the Warld Conference aa Saokia:aS and H+as~.h, Septeah^d 11-13, 1967, hby E. L. Wynaar and 0: Haffewon (Oda.) (U. S. Aistiontl CQncar Iaatitute Mouogranh 28) 216K& 282 Pagea U. S. Dept. of w.-~kalth, &:ucstion and Welfare, Public Iieaeith Service, Hatioaa2 Caacerr Zustituts Betbamds, ma. ~ 3M- 0 900 n02S23__3
Page 439: wrm95d00
l~ANAGEMENT--PI.ANNING/ 50335 29 56 76 I Ka-79 - Arnoldo C. Nax and Nicolas S. Majluf Sloan Schobl of Management HASSACII?SEt'PS INSY'ITUTB OF TECHNOLOGY INI)USTRIAL LIAISON PROGRAM DISTRIBUTE MEMBER Ct 1
Page 440: wrm95d00
50335 2945 _,. G{,d.-'git • . - .,, TOBACCO--SMOKE--BIOLOGICAL TESTING/TOBACCO==TAR--rANIMACEXPERIMENTS/ 76 X Go4 \`. RJR CLASS NO. PAMPHLET 76 X.G a ; Gori, C. B. . , ,,, . . . . .f (U. S. Dep. Health, Educ. We f., Pub. Health Serv., Nat. Inst. Health, ~. Washington, D. C., . U. S.) . _; e. _ . . .. . . . - • . ~ NATIONAL CANCER INSTITUTE tiOKING AND HEALTH PROGRAM. REPORT NO. 1. THE FIRST SET OF EXPERIPIENTAL CIGARETTES. ' :.. .. U. S. Dep. Health, Educ. Welf., Report No. 1, Washington,,D. C. (1476) (in English) smot ' ' *Re words:* T°M constituent; y ; ~ alkaloids, 'smoke, constituent, .a Wateir, smoke,•, constiuent; ; tar; 'ismoke,`constituent; = r: . . . . . . _ , .. . . . . ace`taldehyde, smoke, constituent; " .-~,:..: acrolein, smoke, constituent; forinaldehyde, ' smoke, constituent; gydrogen cyanide,-saioke, constituent; , nitrogen divxide, smoke, constituent: ~ carbon monoxide,"smoke, constituent;
Page 441: wrm95d00
,~~•- rs~:'_`;• 09 : l"r 'oN u,o; rnq uopef•l.;:o;caI axn:~YnZq-ADv L. . . _ .. rT33?d:r.ii+t S'^.f3:c ,._17-T.-c! ~'.ti',l7 .L di332i v -*:Amd 41il 8~~,-,2Sd"j l4o.tcF',t:all 'PL': f9:3L':'l.-.-oT.+aV ' a.jTrso;4dv ;o quaa3svric-Q • S • P, SaWd ei-6Z SEfOS -
Page 442: wrm95d00
50335 295s s:~:"~.,~'~''o~~- p , . ~Q ,361 ~ Ru ~ ~ ~ a Ruch, Theodore Cedric, 1906-- -Neuroph,ysiology ~hy, Theodore C. Ruch (and others, ed. Philadelphia, Saunders, 1965. ziv, 538 p. lilus. 2T cm. 2d "Reprinted from Physiology and biophysics, 19tL edltSon of IIowell Fulton Textbook of physiology. Edited by Theodore C. Ruch ... aac Harry D. Patton." Includes blb2iographlea. ~ 1. Nervous eysteaL z Tltle. QP355.RS 1965 612.8 Library of Congresg \ ~ 17-11 ..+. +. -~ ~+r...,~. .. ...y~s r..•w. . 65-2564 0 so o002S247
Page 443: wrm95d00
Page 444: wrm95d00
50335 2952 , 22L~p "'loward a'ol.uticn of the 'Jbar: cco-C^ncar by L. L. t~i;rndor. u ..ae.a='Lt4..i.i6 C31l _.-r-C- a:. Gowtrn,7rt.-tst- 0Y~ r,,, tJ.^n : ~0~+5d ~'j /t~pt6f6Ato'Ei Vtt: rMLOUNf'+ 61%4T::RTY ~h::f :- tt rrn" . ., ; . _ . "'. I ~' TC6 , r^. ("i.._ .'i ~rf$:iCii: S ... . . . -r....,,,.,..,' _ . ... ., _..
Page 445: wrm95d00
_>l ,,_ _ :_ -_},,. I t Jd ~'~L~~ ` .t i r t9X tlEg .icTy' 79 X Re-a) sL-1 9 / atr,U1l'tr, JJYV S.P. by HELENE G. BROWN, Chairman,lVational Public Education Committee, American Cancer5ociety, Inc. It is very clear that the tide has turned in favor of smoking control worldwide. Adults have been giving up cigarette smoking in record numbers and fewer young people arc picking up the habit. A recent study for the National insti- tutc of Education of the U.S. Govern- mcnt indicated that the smoking rates of young men aged 12 to I R have de- clined by one-third to the lowest level since :19b4. For the first time in history, the percent of the male population ' who arc smokcrs is below that of wo- ~ usen of similar ages. Even among ~ voung wonA n 14 srokin~ r:,tc ha~ smokers feel a lessened ability to con- trol external events and their own be- havior, and lower self-worth than their nonsmoking peers. Most programs faiied to address the different psycho- logical needs of the young smoker. Currcnt. approaches to smoking -prevention focus on preparing the in- dividual to deal with life stresses, to enhance individual self-esteem and to make decisions against coercion into smoking. Young people understand the immediate etl'crts of smoking and how the effects relate to the quality of their iivcs I
Page 446: wrm95d00
50335 2955 . ., 72 %I ReZ 77 " S.P, Cullman, E. M. I *(no affi3.}* .t = P.3R CLASS NO. Ph`ff'IILET 72 XI P.e2-77 s,p. New York Times 1977, p. 30 (June 14, 1977) (in English) i~}se major cigareite "wholesaler" in as well as local concern because cioar- 'the New York asca today is the under- ette bootkggiag has been extended 1 world, which accounts for rsearly haif to ot.ier pa;;s of , the co~:ntry by or- ' ot all cigarettes sold here. iyanized criniinaJ elements to ~.ise the This grave situation merits natin :1 ' proceeds to iLaher their illeval,drug - ~ and other u~-~lawtut activideS. ~ .....:.+w~,:..~..__~. ., . ,
Page 447: wrm95d00
50335 2963 Speciai Libraries Association. Directory of special libraries; compi.ed by Isabel L. Towner. New York, 1953. 297 p. 25 cm. 1. Libraries, Special-Direct. i. Towner. Iaabel Louise, 1884- u. Title. Z675.A2S63 ~ 026.0058 53-882i Library of Congress C-) i54q151 4 0 500 n 02 5 2:"52
Page 448: wrm95d00
50 335 2965 RJR CLASS NO. PAMPHLET 75 VII To2 Specht, H. B. (Canada Agr. Res. Sta., Kentville, Nova Scotia, Can.) ORGANOPHOSPHORUS AND ORGANOCHLORINE IV STICIDE RESIDUES IN SOILS AND UPTAKE EY TOBACCO PLANTS. ~ Can. Jour. Plant Sci. 55 (No. 3) 835-42 (July 1975) (in English) *Keywords:* chlorpyrifos (Dursban), tobacco, additive; leptophos (Phosvel), tobacco, additive; methidathion (Supracide), tobacco, additive; N-2596, tobacco, additive; heptachlor, tobacco, additive.
Page 449: wrm95d00
50335 2957 1 ~ 2240 Tr .~ ll::TC:~ ^1~ (Shfaz-aatiaZ on Raw Tcbacco,)s bv JoUeA'O Trc, jcn~e Et'Iac3yelaw,,au3 Kazirderz Dabrowsk; TY~V~e'13k~ 184 pa-les 't:~~dawaioltwa Prze.VeZu Lekkiego i Srozywozogof ~~ trsza~v, 1;'~~ 4 050.0 44.,,2 5 2~,4b
Page 450: wrm95d00
1 50335 2967 ~ 1 I -k- TQXFCJL~=Y OF 4XLDsS OF NI2ROGM4. I. "s"O.:IC fA NCEN'TUTIONS, by Leroy W. Lo. Tttwsky, E. L. rfacQuiddy acd J. Perry TollBaa Jour. Iad. Hyg. Tosicoi. 23 (No. 4) 129-133 (April, 1941) 0 0 S 0. 0 n 0. 2 5 2;~ 6
Page 451: wrm95d00
5Q335 2964 ~IX R e 2 0w~. U~ .4,1.® 8,5:,i:h47:.~ (196h) .......___-- ---vevw Rcsseablim, l3. ISGT(?PIC MASS RATIOS, 2'~AGNWIC M0"1MEN-?S t~.'~D THE Si OF TiiE EL-; GTiuC DLPOLE MOASErtT IN CAUG2i i B. Raneablvm, A. ii. t,ethercot, Jr. and C. 11. Toune; Phys. Ret. 109, 400-12 (1958) L ,-„q Wou I - ~140~, 4 50 0 0 0 2 5 2 5 3
Page 452: wrm95d00
50335 2968 _ ..,..~.. ~..:~ =- MI^Qiicdy, E. L. TCt:ICDLOGY OF OXIDES OF NITRUC.F.'44. ZI. y ~. L. A:awQuiddy, Leroy W. La Taw.,x:y, J. Ferry ToZiman, &nd klistar I. Finln.yraQB 3,-.;:-. .'.ad. Hyg. Toxfcol. 23, 134-140 (1941) (7) O500t?42 5257
Page 453: wrm95d00
by•. Patrick J. Whaling, Richard T. Barber, •Dacember 1976 The work upon which this publication is based was supported in part by funds provided by,the Office of Water Research and Technology of the U.S. Department of the In rior, as authorized under the Water Resources Research Act of 64, as amended, the f2)Water Resources Research Institute of The niversity of North Wro ina and b Duke University. (I ~n-2 &- o ~. _.~ :-T.. ' UNC-WRR I_77_1Z3 ALS IN MARINE ECOSYSTEMS ::- AS A RESULT OF&WASE DISPOSAL Duke University Marine Laboratory Beaufort, North Carolina 28516 Project No. 8-071-NC AND NATURAL'PROCESSES Agreement No. 14-31-0001-1 . , ~~a ~~.
Page 454: wrm95d00
1 : III . y ~MeAs ; (1968) 50335 2969 Perry y.~ LJAM~x• , T. rpoS OF QXIBDS t3F NIT~'iV Ti+ii4~ ~Tc11....2nt 7~ ~.y,~E~L~M' t~~J~~'..(~+Cy ~,d 1Jt~~~~ ,c.ap 1.II Schonberger ? fn3. w8• Toxico2. 2~, 24?-i'~? (I942) . --~--s-=
Page 455: wrm95d00
CRITICAL CARE f~[EDICINE 81 I X Re.,- S.P, ar . ~.( .3) / 9d c /txYP f ,'1 CJIR80N IpqxIOE, MrPOxll'AlrD CICAREfTE l11DKIMG: EFFECT„p/ Yf11TIi.ATI011 r Anasi.wsrPatrick sraa, daM Or.aron. Osaart.ents of oq~r and Cr/tical Care llsdicine, and SNr9ery, T#~e ,bhns Ipkiaa; Univarstty ScMaol of Msdictne, aalttaore. Irryland 21205 Ttr tffscts of rantiiatian on carbon ienexira taral and iqPoaia drring aad aftar ci*rette saottug aare strdiad 1w tAe isolatad, larfasad and rwtilabd canine Pu1m"ry '1Mp 1009. TMe iatas irre ventilated with tvoo air at a coastant rolaaz and 'erfasad witA artoii+*rs blood at a tonstait flar rate &Ww -- t iq* MMla sxW- stsnLal perisd. Qftav' tQt !il*flifitiaR. faR SalaiR fitterad cif.eettes t" oosrtfiwartil+ 'a.ahr/' !r 1 MI! 1lsrwrN aAis1 raatl3,PW aM this rseke iws 41t+reraU to t4a 1aie. In . Oresp IJ4 :1abs), sltA iww.1 woNlat/an. 40 0 0 IS 1Orr~ aNa ~ titsiratlM ~~l0Rj, Sold ~ ~~ ~cewl t of .o.aa~frte°~ ''qlt) DNd. ~Irr sto 's a~ l tMt N ~ M .f r4 M/sM+r C6ab ras NP 49111 at 1K. U 11 t1wr-iairy. Ims-taa.tila- . ttns: iC~ ~ 110 ialer, MR torw a0at"a Ma 1~l~cia, i1RIC. ~r '~IiitY 7wlls a11 ~ e ai #M'rW is- t%a1 ~ bsi* ayMps still at 141. AN'fERIAL ORYipI TEI4SION DURtiiri INCE1fiItlE SPIROMETRY WT~I and lerw p N. pwMey, .Saparbaent of huastiiaNlaW, Mi1!lswl N111 1fW IlNfical tenter, toetiaM Air rwera Owa, TeqMs ?itli. Me arasaatt artartal.oRoosa tension (Pa02) in 10 post- ~arativa i*hasin uanP mait patients before and during laoaativa spirwetry ift#M flfllsrant oayyen delivery sys- 1rs. %p, iiet itraSreW Mlrile tsite a face tent with Au- stHflad M #t at 16 Llsia (iTfO) and at the and of 5 oiIaates N 100nti.,e .e.~t,~gr a0 taar air (ISRA). Pa- tiauts in afAa. t#e Hi~~ ?3M was S TO torr rere dcemed iuet IrMWY1 of srqlaawtal aq9an an1 were studied as #1ISs. A1ieMt» 20 ~IOe sest fatervals Oetreen letts. PaMf 11atssoq~St tMe aisd af 3 aNfttes of in- iylntivt ryIii1.:joserfag s#t face tant as previ- airsly iper#1~/ .tO tlte 0t:wetar olace0 in a! liter vW1Iod wft ~ W 02 at 15 Vs~in 1;CfA} aisi at tAe N 5 Niwtss' of incentive 1i'pwl+7~ lMiin aaso1 paAllfae at i ihln 02 (rtSL- ~w 1. TjW dfffsraieas trphiew tfrat h02's wre ca.pared atoM Mt1MMt sslag !M! 3t/Mt's t-Lest for Mirad 11la. 4M Altas"atpt ~ttnlan i''AO as! FTSO-IS40 mos not ItigoffiCm #ii#RSl* tls latter as ssirll h1oar. The w.M Offorwa brw. fM end tM ws is torr, r .`ft alm NflW aai:a ilttMan f TfO-I$50 and ISRA 4016 1liWae sirNlpat. 1sAM0S. Tba 1/fferance 6e- traaa MCK-IiP/l aw I!M as 1; tarr. r.Ot5, but aany N tAe NClL-IS#!l 's rore 1 70 terr. . Ne uncl„ee that Tor Mtiants rho require sappleaen-
Page 456: wrm95d00
I 50335 2966 Foal~-- CN~,~:CAL ~~~rr~E~~ ~3;oZ3~&~~1~~4~io~~~~-~ ~~~~ ~~ f: s/'ff FooD - fiuZ AWS/FboD~-- A!: eet-a5:t~Co G F4u, ~r .'.. ~ y/ Q rf a*Ti iV4E 8to wwi NG1/+lEAT - - AG;n+ fs VECETi4 0.1., ;55 ~P 37t~ ~'- ~3Ro~.,nr'.wGI~ticEol3iaLo&y --IfooDI FeOD-- Spa;t-A~6' /9'!1 Biochemistry of Foods N. A. M. Eskin H. M. Henderson DepQrtm•ot of Foods and Nutrition Depwtwunt of Food Science TU us4avsity of Manitoba The Uninessity of Manitoba wwxrpw, Mcnttola, canada Wiurnipeg. Mmritoba, Conada 0 5 Depa-tnient of Food Science and Technology borougk Polytechnic 0 0 0 2 5 2 5~SE.1,~land ..
Page 457: wrm95d00
,~e~ nInRA'a/ 6r11rliM • ~,, i97o, 1'al: i.t. Na S, 956-914 a GU4%,.. /. , 80 II Ey - S.P. Nanctan S. Endkr' David Ma usson York Untaerrsfty,`Toronto, Canada Uniper:~y of Stacktwim, Sueden. The major ebar.rteristies of four bsic modeit in pasoaa7ity remarch (trait PaY601OQ', PsYthodynamia, sttaa$onism, and Inlaadioaiim) were reviewed. Tbey wrere compared with respect to (a) *W pf 3ttirs sousht, (b) determi- aants of behavior, (c) units of am6mk,, (d) 4e oomdstmcy veratz specificity bue, (e) aatop,eaetic dtvetopment of bebsrier, md {f) ritaevh strategies and porutattonr sampkd. The adequacy of the trait aodei 'u a general model for empirical personality research was dinnrcd. 7be dhicmidon focused on the ceatroveesy betwrcea the trait modet and the inteeacNoat) mpdel. Z7u coadu- siao was draera that the tr.it model b limited m agearra] basik for the use of pasoanbtp dara in deeaiptton and peedction of beharjor and as a*eaerai basis for peeeoaalitr nerasch. 1ndead, the empirW rewlts support an inter- aetlonat vhw of behavior, in .hich actoai behavior ie deterndaed by a eoa- daaoa and muTtid'u+ectfoeal Interaction bftw rm pes.om t ar7abla and situation raiiabla. Tlie issues and rneaeeb oa aMaatiaeal detamioantt of behavior were ~re.lewrd, =d The need for more qrstamstic pWsAolostal stndlee of dtnatiom • was strered. The major hature+e of the iateraetiomat model of peesoaality wexe ' discomed, and the aeeadt7 of devdop3ng methods for iavestiptine continuous ialesaction pRoeases was emphasized. 2 c1 ~ ~ A tf` 0 2 5 2.3
Page 458: wrm95d00
50335 2975 CANCER--STATISTICS/CARCIN06ENS/ Wa1 1980 a ieport to ths president by the i'ozLc ftbstanoss ftrat.dy committee
Page 459: wrm95d00
50335 2970 I VI Nol North '_%ro1i~..~ State CoZlega, Pasticid© I FG!'. =t;$ I-_3o~-a to*- 'y } C1•:r ~ s,.ry T~~rtr~nt ASTi ;IL-~. r~:S1f~:~S ~~ut;., I?i T()BtC,C,O SAt•UUS IAKEh ;11::M biAP,F.FiCt;S:. FLG~'•S IN 1957 , 1 ro Fn - typad o !~' ,%-_ '".At6 Co11ego, I?apt. of A". Chom., Degto (195.,, 0 .. ~._,.~ ..,K,.._.<...e.-.,.._..~-~,.v . ~.,~.~...r._,a...4..,..,,~...,~ ..~..•..,.-r..-..,_.~.,.., c..~» 0 5 0 0 0 0 2 5 .2 9 9
Page 460: wrm95d00
1 79-n~=81 CONSUNER POLI CY/TOBAtxO--SI4OICI NG/ („/rsu~ e-.ATktO6 Se , i iJE CIASS E0. PAMpBI.E? 79 ZI Dai-Rl •aaiysis Consumer ft2iclr, eonf. paper,YWo. ft., -1lhartoa Appl. ites. Cent., Philadelphia, Pa., 13 p. (ilay 18-0, 1981) (in Eqglish) nZ uentioaad. ' I hope to have sh'own that the ideological confisnration at issue lwcre soes for beJoad 22iis or that vested interest in the society. In the final amalysiit, it riiises `tM'- qusstlon of sbat the society Is to be and what are its. chasca of survival. In history, the +qnest for total security has regularly been associated with the phenomenon of decadence - that is, with the i~71~J.~~_~r ~L •1.~ waT...an f~+fl•.^..+, ea w.....~..1....J ~ ~,..<,s~.._. ,_9 ~s.-_ __i._
Page 461: wrm95d00
50335 2973 .- T 55 Bo 1977 Contract No. W-7405-eng-26 ORNL/TM-5722 (Volume II of ORYL/TM-5721) HEALTH DIVIS ION ~ndustrial Hygiene Department MATE£.IALS V4QFETY DAT SHEETS THE BASIS FOR GQNTRAL OF VOLUME II UNION CARBIDE CORPORATION . . ~ $ I for the ~lc'Ridge, Tennessee 37830 , operated by N. E. Bo3 ton ! Da te Pub i i shed : May 1977 Z. E. Ketchen W. E. Porter C. L. Hunt -v QAK RIDGE NATIONAL LABORATORY . o ~R(~ RffE~,Ci~v`~D*ELOPMENT ADMINISTRATION y ~ '~
Page 462: wrm95d00
I ~ ~ :~~ 50335 2961 ._+ 11 Mes 74 Jour. Enviroszmental Engineering Division 100 855-67 (1974) S.Y. Ahhouth the pipeline transport of solids has been a cotnrfercial reality for a munber of decades, the high costs of labor and maintenance in other transportation systems have intensified interest in pipelines in recent years. The chief adwantaee of this type of transportation is the capability of thc ~~ economical utilization of smaltl diameter timber for pulping processes. Since 7 I f C d h P P R h na aper csearc nstitUte o a a(.;'? has been Investtgatmg e utp and 110. t teasibilt'~ood-chiP.. P.PeGnes in several wa : ea i il' s' ~:.. ...- -...~.,..~...-. _ . 0< '' . I)Y • ~ ILEACNI\G OF POLLUTaYfS FRONI WOOD-CN1P SLURRY/ h!: Sr akashl ,lsaao.' M. ASCE, sad itebert L. 5ant:s,' F. ASCE J V ~ • tlte possibdity of using hydraulic pipelines to transport wood chips to processing p4ats. ln 1961. htontana Stati; University, in cooperation with the Intermountain Forest and Range Experiment Station of the U.S. Forest Service in Ogden. ' Utah, began extensive investigttions into the feasibility of hydraulic transport of wood chips. Oae of the eeajmr factors affecting the feasibility of hydraulic transport is ' !be ettect of substances leached from wood chips into the carrier water during ~ &e trattsit period. The leachability of the substances will affect the economic
Page 463: wrm95d00
jai A droeadnl Mrictrre is Oaeribad 1o saoo.rt for a.ariety of phe- stamena aireoanter+sd ® Wc st.O of *eeeaptian, atbatioa, md ewoory. A!e, gslem is P npo.ed aiiieh Irs 2 digennt odes of acti- •atiaa: a esmporary ecdtatio4 odkd ttmct-ara or *r:aaq .br.ge, and a t ermsoeat excitatiaw, cafled ioag-serm or xoand.ry stora`e. The Morage ib ss.anea fo be orpaissd so dat srooe:: to fbred ittbor- stiae eaa be arde dited* from a swsorr aode. Tiw& &e initial iamerpe+atatioa of aeasaer e.aua can be perfoea.d aseonatidlf, al- lpoiqg attention to be directed b e.ents m the iws of tlieir sAanin~ a*d .ommta*y psnhoiogieal farlaaaa. A>etrieql Prooert is de- .crile! to hradk the probiea d daid'wg wbs an ilam t6at is re- oere:+ed [erom oxase is drt .rNch was .ouNht. Tbe oatpat from sbca~e is aecepkd as .afid ady N it nn kad iadk nr6rragy b tbe erigimat qrery of aom.ery. If it on.at tbe rasrierai ~+ers aenR inues, sritK the initial q.ery twdm with ath i~ersae4e•e ertpt ft pide de " ~ Ptia. of wedt. tdstrlly the uvtd "memors " tneans the nesman6rsooe af a psst event, but in that naeretnbtsnoe may things are iu- vol.ed. To be reaamnLercd, infornu- yien nrast- irst -be soqttired, Nwtt re- lafeed in a rEora~e s}-stetn, and, finally, "be rttrieveA xhea sought To ne&r- 1 stame m sw necessarily relmatett to Mtman hsharior. Yet it is possfble to organize theories of the various aotn- ponents into one consistent structure which, even if not accurate, may be of sottx use in guiding further thinicitte and exploration. t l '
Page 464: wrm95d00
CYCLAMATES/ETHYL ALAOHOL--P1iAR~tACOLOGY/FREONS--TO:{ICITY/FLUOROC?1T'.IiC`NS/ FREONS see also FLUOROCARBONS/MYCOTOXINS/NITRATF.S/NITRITES/NITROSAMINES/ PESTICIDES--TOXICOLOGY/VITArQN A/ AEROSOLS/FLUOROALKANES/ARSENIC/ASBESTOS/ARST:NIC--TOXICOLOGY & BIOCHEMISTRY/ BENZO(a)PYRENE/CADMIUM/CAFFEINE/CANNABIS/CARBON MONO~CIDE/ eqj ~NC~~-r CARCINOGENS, i•., MvSATION/AIR--POLLUTION--CARCINOGENS/ . .r..... , ~tCL. Tozikol. 31, r'i"•f9 (1974) ' p by Sprinser-Yerlag 1974 75 11 sc Review of the Literature Lvorc ScHLosssi. TbKww.r~f A„ ~ure, which supplementa VoL 30, includes reports pub. ' Bhed in 1973 on --•____~ J-.__-:_., z. eI.-,_ Titles are -- ~~.. _~..- ri.en in tbe language of publicairon. monographs 0 S©~ o 0 2 5 2 6 1 A!1 drugs are listed in alphabetical order under non-proprietary aamea as approved or proposed by ZYHO. These substances are so numerous that many of fiam have been grouped under general medical or chemical descriptions (e.g. anti- ooagnianta; b3pogiyeemic agents; phenothiazines). A note under the group heading ind%oates when agents are alw listed indicidually. Plants are given qader their b4nical naeaa. 76 review it.pfieaeded bJ-a list of the monographs published in 1973. I
Page 465: wrm95d00
50335 2960 ENVIRONMENTAL R3IILTH/T07CICOLOGY/r - ---• . , .CADlIIUlI--TOXICITYI TECHNICAL REPORT DATA (IY.Ixr 7.J taatnNY+iru ua rhr rrriru• Mynrr raafplrH+yo RA 1231 8a 1978 1. Nl PoH 1 NfJ. ~ - ~ -~ ~ - - --~--~ - ?. _ EPA-600%1-'I8-026 4. :. ----. .. tf Tit Arou suuI11LE RGPOIIT L1ATE jum 1978 Revltu~ of the Environmental Effects of Pollutants: . Pf flg'6RMtac3 OAGANIZwTt1JN 001 d IY. Ca miwa LeviR, Bradford L. Whitfield, and ©r'aunsteln, 3ohci S. Drury, Cnrole R. Shrlner~ Eric B. ;~ a'uit+iinls~n~ynons, Jame's r:dwar~Tr Huf, f, Helen M. R PEAfOAMir~G OqGAN12ATlON !#~ Ii. PERiORMING Ufit:ANIZAI'IqN U/AMt AND ADURE Ifit. taOGitAlN ELEMENT N1, 116 Oak Ridge National Laboratory Information Center Complex, Information Division 171. ~1 A" / ARY NO. Tennessee 37830 . t iAG D-S-Uav3 Oak Ridge , 1?. SrCiNSOrithtG AGENCY NAME AND AOORESS pernistesrce in the envirasuaent; assessment of present and potential health aa -_ -.._. -__. _: _.__a_..,,.. -d vern~ental regulations. 13. TYPE Oi REPOqT AND PERIOD Final 1{ , SPONSORING AGENCY CODE SPA/600/1a ,+his report 1s a reviiw of the scientific literature on the biological aw envirocisEntal effectt "eadmium. Included ixe the reviev are a general summW and a~t+.~ptt~~nttesi~re riiac~tssidn ctf -the following topics. as related to cadmium ; specif ie ,caAainet compowrh: physical and chemical properties; occurrence; s thcs3,a'ao usei.saalytical methodcilo,gy;1 biological aspects in microorganis ~n$. SLld.a* t1Acsftc9n*i.;4* humans; distribution, mobility, and fLealth Effects Research Laboratory, Cin-qA. Office of Resear6h and Dswelapsent U.S. F.nvironnental Protection Agency . Cincinnati, E3hio 45219
Page 466: wrm95d00
. 50335 2976 T1' {R ;370 ;Li . c /o l } ~ ~ L.I.E9t3E1r , r :CY.:~ ~ iXv3Ct i:. (ea.) cr'ia-MIuE:rrs CF PLMNfi FOC1;ST'uFFS (Foca Science aad Technr,fogy, O7r iRoil4oL'ltgSl°3 no. 6) a a6rlce 1969 ~' /~~8~, an^-~ •-YE - 500 P-L=~ t~cad~mic PresR New Sar's
Page 467: wrm95d00
I 50335 2980 -- ,....... A,z - nfl~ •, R~ . t9?:2 soo (r s7.2) vl l~~• ~" 7~ $~ CHAPTL• R 33 NR%o ITtVIN ELLT •LKER Uuiyrrti y of Aliu,usota, USA I.Introduction . . . . . . . 481 IL Naturally Occurring Toxicants in Plants . . . . 483 III. Natu:ally Occurring Toxicants in Animals . . . . 495 TY. Adventitious Toxic Pactors . . . . . . . 496 V. Conclusions . . . . . . . . . 498 Itcfcrcnccs . . . . . . . . . . 499 L INTRODUCTION One of the most drataatic and certainly controversial dcvelopments in the food industry has been the usc of chcmica.i additivcs for improving the functional propcrties, nutiitionsl value, and shel[ life of food products. The introduction of these foreign chemic.2ls into our food is under close turvciSar.cc by appropriate government agencies who atc charged with ~,~_...~~...~ Q__5 11,:4 - .2.-T- 2 116" „9.~r.,.~.,,.,.-
Page 468: wrm95d00
RADON/ltARIX AIR--POLLUTION--PARTICULATE MATTER/LIGHT CARBON MONOXIDE/PESTICIDES--TOXZCOLOGY/ODORS/NOISE/LEAD/RADIATION/CONSUNER PRODUCTS/ AIR--POLLUTION--HEALTH EFFECT/ASBESTOS/FORMALDEHYDE/ TOBACCO--SMOKING--PUBLIC/ CLEAN YOUR ROOM! A Co®pendium Describing a Nide Variety of Indoor Pollutants and Their Health Effects, and Containing Sage Advice to Both Householders and Statespersons in RA 576 - the Matter of Cleaning Up, 'C& AND IIiCLUD ING 1982 -~--t MOKUND G. SROiWN JR. Governor A List of Sxperts Who Snow What They're Talking About ALICE A. LYTLE, Secretary State and Consumer Services ~_ Sq.ncy [CfM 8. SP4HN, Director a8 iASLL AS 4w. @sparlssttt of Consumer Af fairf
Page 469: wrm95d00
50335 2983 SB G4'~d Ilcait:tz Of To~,c hazards of peCticidGs to • ~~G. no. 11d) k~ groclp. Genl`v Ita Tecbnical report fierfes, 51 P• tables. 24 cm. ( Biblioin'aPhs : P' $1' s.Title. (Series) 1 peaticides Toztcolo-~y• 57-9,; ItAB•A25 no.114 LtbrNrY of ^opgresg
Page 470: wrm95d00
. 50335 2982 CHEMICALS-SAFETY MEASURES/ TOXICOLOGY-ACUTE TOXICITIES/INDUSTRIAL TOXICOLOGY/INi?USTRIAL CHEMICALS/ , I (ITT) The International Technical Information Institute ; 4:~~ X A v TI T t Published in Japan in 1975 by the International Technical Institute, Tokyo, Japan Ni 96- ~~~ '10Mw*nwtw
Page 471: wrm95d00
_A 72 II va MM-T0XICIT7/ TOXICOLOGY-FCUTE T07tICITIFS/ INAALATION/ ANIMALS--".'QCICOLOGY/LUMS--ZMHALED PARTIC;3LATES/ ' OXYGEN DIFLUORIDE/HYDROGEN FLUORIDE/F'LUORIDE/METHYLISOBUTYLRETONE/ MDHOMTEiYLSYDRAZINE /HYDRAZINE 4k . AD 714 tf*ZA A i.'H` 11917 70. j. D. MacEwen. at a1 Systemed Corporation Dayton, Ohio August 1970 f NATIGWAL TECt{NtCil!. il.F0RMATl0N SL•MICE 694 , .. .. +..- . . ..+ . tLLf1ErARTYEMT 0F COYMERCE +.• ~ ~ -_e .
Page 472: wrm95d00
t 50335 2977 VIP 162 L Arch Intern Med/Vol 131, Jan 1973 • yarrhythmias in monkeys and lower arterial Contrary to their reputation as being inert, aeroseW fluoroalkane propellant gases (Freons) are rapidly acting and potent wr- Aiac torins. This discovery, first made In mice, has been confirmed during adequate oxygenation, either in vitro or in vivo, in tats, cats, do-s, monkeys, and man. This Mitf revi!w demonstrates that propetlant gases are toxic to the mouse heart, enter the blood 2`ter inhalation, and. despite adequate oxygeastion, Aquickt,y cause ventricular taeh- ~ 50 Q A© 2 5 2 b b _ _ _ -Ile-, w__- .-_ _..:~.. . ..~ _.:....~ :_.__ XHe -73 iu. ~ic ~Effeets Qf Aerosal Propeflants S.P. aa-,Ahe Heart Trillard S. Harris, 1iD, Chiugo AerosrA Fropellanta/Harris presswe and p^r+ph«rat resistance ir± severat species, and are directly toxic to ventricular myocardium, profoundly depressing its con- tractility in a!1 species studied, including man. Ventricular tachyarrhythr.iias, bradyar- rhythrnias, acute heart failure, arterial hy- potension, and asphyxia may cause sudden death in youths who deliberately inhale aero- sol propeAants. The po:sibility that these .gases are harmfut, acutely or chronically, to trequent aerosol users requires further studY. I
Page 473: wrm95d00
ILS6i) 61-IIV `EL 'taZxoil.:u •totizgd •.zr.or • ss3~ang •,~ Pus e13aa.t '2?IY 'LLIM u-X1^i:S MOV ^ t:•'.1ZQ iio 5.il'i::I'IZi 30 0I:'JZ •~ •~ `3ty.ud 3IIK Rblt4-~)Ieii6~- ~ d ~ 4l+dv aQLXo7.d WAWI&S dB aI,XAZ... II t 6L6Z SEEOS
Page 474: wrm95d00
N! SoId0111INOI1MKN3tN/ N3WN ~/ . /iiA~~iB~'9 /~0'IO~ IYO.L--S1YJ.3id/ S I SI'lYt1F~--STVL'~t / ,vn / ~Li/h3A'iX S /t~U3.i'1"15 /fi+J1ll:a'13S/I~..'1.\l.i.V"Id/itilluY'1`1Vd/'I3XJI~i/hilAi3(i~11~'It~i / An,1~i~x/ dSd~Y".~b.Vl~./ivi111LL1'1/ V~ d't/ ~,un I! U'IU;1/h:IddUJ /,L't~r ~Itl:~/1.,1I~iU2ii~ E1lt.uV:~ I1~tUbUa / llS~lii~5 t:~ I++i~I'1'lAa~L / lk. iI u~ u/ Lil IT1A21:~4i /Hil hf V!i /:JI ti~ SIV/ANUY T3.KY /A2i.L:3iiUliJ.:):IdS NUI3.d?1USflY :1I:iU.LY--tlJL4A'tYNV `A21.F.SI1rAtl:) llnlLVitaii~/.~iLLaiKtlil,W~dS WJ1.Lu2tU5uv :11kUJ,%/SISA"iV:vV -S,L,ti3t;3'Ia S3tf2l.L 686Z SEEOS
Page 475: wrm95d00
4 • , uacslCAUKIVWLEADI , ' ZffROMI1M/ III Me4-77 S.P. Jour. Environ. ealth 38(3)168-9(1975) By Kah-Hock Lee, Ph.D., Ctiemist Richard A. Lane, M.S., Bureau Chfef Ballus Waiker, Jr., Ph.D., Director Environmental Health Adminlstration, District of Columbia Department of Environmental Services The exposure of children to toxic each element's respective resonance metals. especially lead; is not wavelength. In some cases, further limited to lead-contaminated paint dilution of the filtrate was necessary chips alone. 11am toxic metals are to brin the ercent absorbance found in hous/%dul~ at~ stAet Or- ~retain~to,Zhealilfiated range. face contamin~'nts.'t'Recentf~'•'an un- 11 Tabte I gives the various con- centration of metals of printing ink samples obtained from the locz11 plants of the Washington Post (WP'± and the 1Yashington Star New.-, (WSN). Concentrations below 100 parts per million (ppm) of 0.01 of the weight of ink, although detec- table by the anlytical method used, are omitted from the table. Table 1 indicates that only red and blue ink used in the loca ( production of the two newspapers contain lead, chromium or cad- mium. This is consistent with the fact that in all of the regular news columns, the yellow and green por- tions-excluding the Sunday supplements-contain only minute amounts of the metals. Their con- tents are comparable to that of a blank piece of paper.
Page 476: wrm95d00
~~ °` RJ ~ ~ ~~ R LASS PAMPSLET 75 XZ W79 S P. a-. Kiani Neaald Mia_._._ .,. ~ei Iie+aald, I9~, p. not__ given, r. ,, 79) * (in English) al~ p~a~d to cdu iww "TU Cqpm Capitd of the Uag- .d Btatas." liom of wwmvth RJ• RcyAOlds, the ia*ja : : ltO ieulat. tbis d+qr produm mace ekwaft #hou =w othez in tbe aooatty -- `200 bOon a Year. Wbcivg in SU bMim ia worUW& sdaL . Win.t+aw i. 9he SOtio4'a ; iwoeKt mat popWw btabd; Sskm is the iouttL. Tf~o sta- ' A06m ao .4 ouquaaw " if every Ammm s.wk.t fte h.a *aiet a ft, wynolds-"add lo.. = =7koo' ; ~ WO tint k'md d' noacy im~ved, no ons "mPtsm Ap St 6watms am becmes inomerwd as t6e .~y ' ered odae of U4 tob•ooo. twit laders ad! 4 '"Uo ~ ~~~ - ;-•-, .; iv
Page 477: wrm95d00
Atruro Micanm. g, F 974 . 337-339 •. opynK 1974 Americanur . Oru iolow M. T. WU,' J. C. AYRES. P. E. KOEHLER, axo G. CH.kSSIS' Department of Food Science, University of Georgia. Athens. Gear,,*ia 30602 Received for publication 24 September 1973 Mycelial extracts of an Aspergillus wentii strain grown on yeast-extract sucrose medium and initially isolated from country-cured ham were highly toxic when inoculated into chicken embryos or fed to mice. Moldy corn and rice were less toxic when fed to mice. Water extracts of moldy corn or rice or culture filtrates from yeast-extract sucrose medium were not toxic. Purification by thin-layer chromatography followed by crystallization yielded orange-red crystals that showed high toxicity..and had a melting point of 285 to 286 C. Chloroform solutions of the crystals had absorption maxima at 2?0. 295, and 452 nm. The smallest amount of this component necessary to have zero hatchability of fertile eggs was 50 µg/egB• Toxicity ofAspergillus mentii to animals was first reported by Rabie et al. (5). They found that strains of A. u;ent4 grown Dn corn caused toxic symptoms and death in ducklings, chickens, rabbits, and sheep. The most consist- cooled. l0• spores harvested from CDA and 300 ml of sterile distilled water were added. The inoculated substrates were then incubated at 27 C for 2 months; after incubation, the moldy substrates were auto- claved for 1 h. In a second experiment, 10'spores were 0 5 0~ o 0 2 5 2 7 7
Page 478: wrm95d00
CANCER--PLANTS/ POISONOUS PLANTS/SOCIETY FOR ECONOMIC BOTANY/ NICOTIANA 1'AiBA SOi.A~yACEAE/ t~! ~ ,iCt~ARCIA~OGE~IIC E13 IACEAE/
Page 479: wrm95d00
x Fo3 __ _._. _.~..~,> _~~.` ~ .._..~...~....~k. _.~.~. Forgacs, Joseph TOXIC MOLDS FGUNU IN CZGASETTBS, by Joseph Forgacs and Walter CarY3 -gorgacs, J. and Carll, W., News RElease, New York City, N. Y. (Sept. 15, 1966) Abatr. in: Washinrton Post and (Ncw lork) Daily Neas (Sept. 16, 1966)
Page 480: wrm95d00
L an€~ ~- 0 41 amarw 6-A-tures i*- Gattle, H. L. Tookey, Ph.D.; S. G. Yates, M.S.; J. J. Ellis, Ph.D.; M. D. Grove, Ph.D.; R. E. Nichols, D.VX., Ph.D. ~ THE UBIQUITY OF toxigenic Fusartun2m molds in tall fescue (Festuca arundin- acea Schreb.) pasture and the seasonal appearance of "fescue foot" in cattle graz- ing tall fescue led to the hypothesis that the two were causally connected.3 56'?'he fescue foot syndrome is characterized by loss of weight, lameness in hindlimbs, and gangrene of feet and tail.6 Based on our observations, necrosis of the tail may be more prevalent (but less serious) than necrosis of the hoofs. Of 57 cattle on a Material and Methods 1969-1970 Study -The gr was synth sized as previously described.' Seven Her ford steers weighing 96 to 171 k;. v.•e housed at night in an unheated barn Madison, Wis. During the day, they Nce turned outdoors. Hair was clipped from tl tail switch to make observation easie Starting 8 days before and continLi throughout the study, the steers were f a ration consisting solely of nontoxic, er_( free tall fescue hay, hy-31 variety.' Tr~: ment of 6 of t}N rs cUnsisted of c e stee . : T : x. .,_ ----~ 54335 2978 - ; IIT Tte„-74 ;S.p. Ij Jour. 11mer. Vet. *ted, Assoc. 160 1522-6 (1972) 0 900 0029267
Page 481: wrm95d00
~ FIRE SAFETY/w4SES--THERMQDYFiAMICS ' ---------_- BiSI.IQGRAPHIC DATA 986 Combustion ofPlastics and~tIastomers. Ca 1964 -1976 ~ i 1978 fA Biblioe i-aphv with Abstracts) Combustion of Plastics and Elastomers. 1977-October, 1978 (A Bi-blio~.zraphv with Abstracts) Tt itor: Diane M. CavaLrnare 9. YerincotnF Organization Vamc and Address National Technical Information Service , 5285 Port Royal Road Springfield, Virginia 22161 12 Spoasorin= Orj;anization Naste and Addtess the previous JMiti0oM it or s.fflsnentar, r>ews_ supersedes 1dI'IS/PS-77/1003, N'TIS/PS-76/0915, NTIS/PS-75/721 Vol.. 1. Vol. 2. . 3. ReNTIS/PS ~/s1126 S. Rtpon l3aco ~~+ f r z October. 1978 ,.. 8. Perforutiog Urarnizatioa Rept. No. 10. Project/Task/Wotk Unit No. 11. Cortcract/Grant No. 13. Type of Report a Period Cf .ed ~ ' 1964 - 1976 h 1977 - Oct. , 197f ~ The cited reports cover the combustion products from plastics and elastomers i , as relatedd to their chemistry, fire safety, -toxic gases, and burning rate. (This ~ ~ upclated.btbliography contains 131 abstracts, none of which are new entries to i . and N1ZS/PS-75/p84. See also Volume 1, 1964-1976, NTIS/PS-78/1126. h ~e ~he~comb~tion and combustion products of plastic: ~~~ , ,~rs, ~ ~~ ,~rs,hewttions cover combustion chemistry, fire safety, taocic
Page 482: wrm95d00
50335 2998 ~. o . J L). ... , .. ~ -,. t^ •~r
Page 483: wrm95d00
50335 2985 'YOXIC HAZARDS RESEARCH UNIT I}ESIGN AND 'C#)14STRUCTION PHASE :~M. rwcnt J. D. TOXIC }i,6~'.~~+(.i:1.:S l>siCa UCti tiitl.i !.%':iliVN iriD {.l-i ...~ rq?'" t,.i,.-~~..t '~7 r 1iLi t`~~i.:s..:,.! ..U3 *'0i r'.4^y.4.Tf ::F,E'.~~G.~S?:?L'.'1.{.' 1L~i ? .S:tE:F.ft~ S~R,~•_. Al... ,.°_ct j•rrn~tR~r~~~ w`~:L!'SYri!~7F'~.^•tII ~1.. Sr. l'~.:'4..rt~.".'.!."71~. ~~ © 50 0 0 02 5 2 ? 4
Page 484: wrm95d00
50335 2995 0 . YIKUNMFNTAL HEALTH/ ~ British Med. Aur.. Vol. 31. Number 3, Sept. 1975 TP 370 Br 1975 :R 'Chemicals in . Food and Environment 0 1NTRODUCTION THE ACCEPTANCE OF RISK CHEMICAL HAZARDS iN THE HOME ASSESSMENT OF HAZARDS FROM LOW DOSES OF TOXIC SUBSTANCES ANALYflCAL SURVEYS OF FOOD OCCURRENCE OF NATURAL TOXINS IN FOOD ESSENTIAL FOOD PRESERVATIVES TOXICOLOGICAL ASSESSMENT OF NEW FOODS MYCOTOXINS EPIDEMtOLOGiCAL STUDIES ~ : ENVIRONMFNT AND EXPERIMENTAL WORK ]tEltCURY AND MERCURIALS CADMIUM - .Ar A. Neuberger E. E. Pochin Roy Goulding J. M. Barnes Harold Egan h A. W. Hubbard R. F. Cranrpton & Frances A. Charlesworth WATER SUPPLIFS AND RECYCLING OF DRINKINGWATER CARBON MONOXIDE ~ o a o 0 2 s 2 eA#OOR REVIEWS Seieet'~/'ie Ediror: M. 1f~eab .thai G. Lloyd dcla•.•es J. P. Drake A. Spicer P. K. C. Austwick t. T. T. Higgins Barbara E. Clayton L. Magos M. Webb A. E. Martin P: J. Law7her
Page 485: wrm95d00
,9OP'# A ~ooo --Ardt~N~cR~$~%~~c p~t~sERr,~r.;~a/ isW /fooo t rov0 . y' A el -/.w /cR0 O/.~t /VerrE/YTt f 0o 0 ,- SAD's X G' v -- vX / - r' e! ~7 r O„/ Proceedings of the First U.S.-Japan Con/erence on 1~~P 8 96'yP- ~ PDAL MYCOTOX[NS • BOTTJLISM " lJ V ~ ~ 2 / e7 ber4 ,)'Y}¢.,de ~- (A' J Ycda VU~e il.i•U4PAN CdQPfaT1YE PP~GRAEi
Page 486: wrm95d00
~...~-- - - 'F~~i.~ ;,*'"w~~'''irs~Cwf` i~i`cvr~i~r`,. ~sth~• nfcc,r.i ~~~ g1kaloi.ds and- xPlatsd co.+.}loundS of Gobac.r_o l4srkiswic$, KswfmieY~ t°bac.cn s?*.oke 1'ElKSYCZI40SC NAJt1L7a'tIE,ISxFCa SR.7.BpjIb;CS:d DYMU y=C?tIIG'aC0 (Toxic progertics of nicogin~, othpr akicoti.Na alkaloids and relg.trd cowl:rsu:,~s, Of tobacco and tobacco enoke) PolAk. Tygod. i.skxr. 20 (eto. 21) 775-77 (1965) - i" Pels1,
Page 487: wrm95d00
1UCOTIRE--PHARMACOLOG7i 1POLLtTt`ION--SOLID WAS'i'SIWATBR--POLLIJ'tION --LAWS / AIR--POLLUTION--LANS/LAWS b LEGISLATION/PESTICIDES--LAiS & LEGISLATION--FEDESA? POLLUTION--LAFTS/~~/SAFETI MEASURES/U. S. ---LliiiS & LEGISY.ATItfN/ NdDIATION/OCCUP,4TIONRI„ SAFETY AND SEAL18/ , Bu NEFERBlICS FILE (Vol. 1) vZfAtARDdttS MATERIALS TBANSPORTATIOIi .C.'QNSENT REPORTS u, CHEMICAL REGULATION REPORTER THE BUREAU OF NATIONAL AFFAIRS, INC. 1231 25th STREET, N.W., WASHINGTON, D.C. 20037 / ,r
Page 488: wrm95d00
50335 3001 OCCUPATIONAL SAFETY AND HEALTH SERIES No. 37 .,. A TASULi4R COMPILATION OF VALUES FROM SELECTED COUNTRIES . l1U--YOLLUTION--STANDARDS/ FEDERAL REGtJL.ATIONS/' i PA1tTICULATE MATLE/ CANCER--CAUSATION/CARCI2MENIC SUBSTANCES/ OCCUPATIONAL EXPOSURE LIMIT FOR AIRBORNE i ./iNTERNATIONAL LABOUR OFFICE - GENEVA . I
Page 489: wrm95d00
50335 3002 SMELLjLUCIFERASE & LUCIFERINSjSMELL, PIiYSI C$EMISTRY OF/ PERMENTATION, INDUSTRIAL/COENZYMES/EATZYME ~~~ 5I I qD 117 10 1977 • 0 V U A Critical Survey of Proven Methods and Their Application in Chemistry, Natural Science. and MrA»np Volume 11 Editor-in-Chief * Natural Compounds Edited by F. Korte and M. Goto art 2 Antik~otics, itamins 'Academic Press New York - San Francisc;o • London Georg Thieme Publishers Stuttgart "n(Po•.`~~Si T44yo4 I anamormones 1977
Page 490: wrm95d00
r G 'LKE ??' i.TC 969 281 P980g Hashin7Cc~, D•~' 1 U. S. ~pt• of the Ir_terf aY
Page 491: wrm95d00
50335 2997 tA'tC t 1 T`f_TCT A'T'Tf1~.T ~ 1. REPORT NO. TECHNICAL REPORT DATA (Please read lustnrcrions on the rercrse before eontplcrirrg) 2. 3. RECiTiEiYT'3"ACCESS!'O1+TtO.p pq 4. TITLE AND SUBTITLE ~ 5. REPORT DATE Federal Regulations of in the~ P+.ay 1977 Environment an Annotated Bibliography 7. AUTMOR(S) John Denkowski 9. PERFORMING ORGANIZATION NAME AND ADDRESS g~,~r~4 QS )3 pv /-.--, 6. PERFORMING ORGANIZATION CODE 8. PERFORMING ORGANIZATION REPOk 10. PROGRAM ELEMLNT NO. 11. CONTRACT/GRANT NO. ~ISPONSORING AGENCY NAME AND ADDRESS 13. TYPE OF REPORT AND PERIOD CO U.S. Environmental Protection Agency Region II Library 14. SPONSORING AGENCY CODE New York, VY• 10007 . a,h') / % 1, This compilation is intended to provide a listing of select materi relatin to the Federal regulation of toxic substances in the envi i~ent~ ~ipcoi e OnasZ 5is a].aSeAon the recentlv enacted Toxic Sr stances Control /~ct and on toxic chemical substances in general; ha-a_rdeus wastes are also i-
Page 492: wrm95d00
50335 2999 u~ri.ar. GIe&3OD, N Or aQt! I~ . ..;). ~~`tYTt YC.; ,Gc~;~slin, ar.u 1iaraa.ci C, Gles~art, >`_c:,ert E. ~?c,I ~s. , 19t~3 •;^^ a `"~, BulCicr.ore, Tid. Co.
Page 493: wrm95d00
50335 2993 ItnT/%,ITR/OfRM0-75/4 CxEMiCALS--TOxiCOLOCx/ 0 Tlecemher, , 1975 b. Pet(onrrinp Oryonisotion Code B. P.rforrainq Organization Report No. '' ~'enneth C. B~.ack IAichard A. Davis, RaI h N. Terpolilli , 1. Potforwino Oryerisotion Nome and Address 10. Ylork Unit No. (TRAtS) 6570 Aerospace Medical Research Laboratory :terospace tiedical Pivis ion 11. centroct or Gront No. :1ir Force Systems Con:mand llOT-AS-40079 2 kri ht-Patterson Air Force Rase (lh ' o 45433 13• TYpeo( Report ond Period Covered ( 12. S"nsoriny Agency None and Address Final Report Departrr.ent of Transportation September- November 197 ~'I:aterials Transportation Bureau 1 office of Hazardous Materials Operations ld• Sponserinp Aqency Code lC:ashinQtor_, DC 20590 wrrp -1 rrTexic Point" is a term under consideration by the United Nations Grou of Rapporteurs on the PacAaPing of Dangerous Goods. It is defined as the temperature at which the eattilihrium concentration of vapor of,a suhstance measured at 760 r:illineters is equal to the LC50 of the st:bstar.:e. This is also referred. to as the t'Ter.:perature Tl:res}:o1d of . Toxicity'' .
Page 494: wrm95d00
~~ . ~ PS,~IrDr Ar ow/!. s A-~' IP ~r,~ I~wolA-/~wrsllo~~1 crrr.e /A e •Cs1.prr/~r0A0A/ IRIfcl`&R1At t,0O4ft iwlA 0 lwEAtr1jV/W Nlt`'t~A'~RoBif+Gfs~iE+r/ ~, It#T/ QIt cTERi* A A 6:e5WT~i'fArl/,d~sTi c t~l~~lcT,lcA'io,p~ite~,E o - kn loNik/M6 R~'lAItITip,t~/DisiiVf~c~/oti /irra,~21xr6'rr~rlLi~~ / ~ / ptoA X fo.w~f e,•w 1rq p 0.4 cr~ EOry/ INHIBITION and j ~c p eDDL / CC DESTRUCTION of the MICROBIAL CELL EDITED BY 0 5100 0 025289 ! EL HLlG ~3
Page 495: wrm95d00
50335 3006 a . , i 4y I , > ENVIRONMENTAL POLICY/NATIONAL RESEARCH COUNCIL, ENVIRONMENTAL . STUDIES SOARD/ /AGRICULTURE TECHNOLCIGY/ ~ /ENERGY PROJECTIONS/ FORECASTIMG/ ~ TD Long-Range h~gaalo wwft4w 169 Environmental N--b- m.,4, ,,,9 . . Na Outlook 1980 DMONMWlAL tTUDIl3 sOAlD «YIi100 OA HYYtw RCtOIY= tbdmm Pmemb coma lMTqTtAL ACADEItY OF SCW@= w&&Amgwa. D.~.'. 190 r
Page 496: wrm95d00
WASTE DISPOSAL/SdASTE,,INDUSTRIAL/ ENVIRONMENTAL TECHPOLO(;Y HANDBOOK NO. 4/ HOW TO D ISPOSE OF AND iNDUSTRIAL WASTES Philip W. Powers . NOYES DATA CORPORATION P.rk Ridye. N.w JrsmY London.'Ergiand 1976 A; , Gl ~~ " ~ '. . o 500 00 2~
Page 497: wrm95d00
50335 3004 . VINYL CHLORIDE/FLUOROCARBONS/ARSENIC/ASBESTOS/FREONS/CSEMICALS--TOXICOLOGY/ FIRE RETARDANT CHEMICALS/POLLITTION--TOXICOLOGY/ PORT NO. 2. 3. RECIPIENT'S ACCESSIOr'PNO. ~,PA-560/7-75-003 -1 & EP -560/7-75-003-1 ~ ~LE AND SUBTITLE ' pTRRENT AWARENESS SERVICE FOIi~.-r~ Cwaulative Report No. 1, Part~.{'~ ~_,, r PERFORMING ORGANIZATIOh REPORT N- C-77355 11FORMtNG ORGANIZATION NAME AND ADDRESS thur. I ,i -b,~~ Inc. oiii Park ridge, Massachusetts 02140 SORING AGENCY NAME AND ADDRESS ffice of Toxic Substances 4 B. REPORT DATE December 1975 . PERFORMING ORGANfZATION CODE 10. PROGRAM ELEMENT NO. 11. ONTRACT%GRANT NO. 68-01-2694 13. TYPE OF RE ORT AND PERIOD COVER Annual Cumulative 1a. SPONSORlNG AGENCY CODE ~This cumulative report conta3ns td current awareness documeuts prepare: biw:.ck2; lfrom 26 August 1974 through 11 August 1975, during the first year of a two year project. The-purpose of this pzoject was to provide the Office of Toxic Substanr,~s ~TS,~, -.S. Eniro~nm~ta~Prot~tion Agency with information on new uses. of ~xi i>~ a~spr u s d~+i information of obvious potential vironmental..Protection Agency environmental concern for both new and existing chemical products.
Page 498: wrm95d00
50335 3014 T 55 Sh 1972 OCCUPATIONAL SAFETY AND HEALTH ACT/SAFETY GDIDES/ ASBESTOS/ LAWS AND LEGISLATION/FEDERAL REGULATIONS/NOISE/POLLiJgI©N--NUIS£y CARBON MONOXIDE/MANAGEMENT--PLANNING/SAFETY SUPERVISION t How To Make the OSHA1970 - Wo rk Fa r You ' . ~_-_. _ HandLook of the xViiiiams-Steiger Ootupational Safety and Health Admini.wation DAVID R. SHUWALTER ~ Presidrnt ~ / Human Rcsourccs Consc-rvanry ~~ Tacoma, Washin2ton 'i3nn arbor science PUBLISHERS INC. 1P.O. BOX 1425 a ANN ARBOR, MICHIGAN 48106 . ~ _. . _ 1 0 5 0 0 0 0 2 53 03
Page 499: wrm95d00
50335 3020 ., RA 445 ttn 1973 2 C. r ~ •s -- t .Y ~. ~~~ ~ u Report of the Panel on . Chemicals and Health of the President's Science Advisory Committee lSORTALITl(=-WORLD/STATI TICS-=*IEDTCINE/t~DICI~ --STATISTICS/ _ ENVIROSPENTAL HEALTFI/~r~/.S*MQNG AND REAU'ti/ TQBACCO--SMOCING--STATISTICS/ September 1373 Science and Technology Policy Office • _ V.s. National Science Foundation :
Page 500: wrm95d00
z 0 £ S r Q0 tl 0 5 Q ' `~MUTQLAO PUU Cl-,-nd JO r..r)~.a co ;~ Lr =Y?4g •1ti~fa .xt)CI •Sia7R ~J IsTq" *A °i 04 PaTiddY y""" `r°"d `I:'0IQOI'~ '. £l0£ S££OS
Page 501: wrm95d00
50335 3010 REF Q 151 wo 1980 1W ^ itldord L.P9nbWd-y Edftor M.aat and Paai I1. QftW Aaockft Edftws , ah.l.atiy, Mbhard M. Naqw,`Edwstd MaW" '%acM. and i.aonard BatNfarano . Editorial f1".arcfi AmmisWfta " IAlorld En1fkONInIMlt 0~ 800 East 42W WNt, Naw YOrk, N.Y. 10017 (212) 097-M CONSUL7AN7Si CONTACT: XICS oUre. W so.a.aa. 9 2 9 4
Page 502: wrm95d00
7cR,,.IT& uri 'A 4-k4:C ?~~l 7-o,r.' / f---.I, t~ --11 r-A n r. . , ~ ~- ~ U \j \41930 S. Prepared by ,a~Wuncil on Environmental Quality April 1971
Page 503: wrm95d00
„ = Aftiterature .t&view HYi3ROCA'e"0'sOh S--TOSI COLOGY /OCCt3PAT IONAI. DISE:4S ES / . AIR POLLUTANTS AFFECTING THE PERFORMANCE OF DO~IESTIC A.I~TI:IIALS 0 : . By Raecnr J. LuuE, c ^yirv . ~ F'O?,LUT10:~'s- TO~:ICOi,OG:'jTTtitRALATIfl;i(iA3}[:IM/V'LU CiU ~C7JAESr..IC---TOXIf Oi,fl LEAD---~,~IP./DiSEA.SES--CI+L?SES AND 7KEt7F.TFS -OF CAIi~.A.Z4!<f y`E.:.Rli+hh~Y MI)ITiT:E/ , PaWic Health Service, U.S. Department of Health, Education, and Welfare. _ Agricultural Research Service lnia review was acpqWted in part by funds from the National Air Pollution Control Administration. Consumer Protection and Enviroamanta! Health Service • s"tancA pouItry husbandmaa, Animal Science Research Division ?l.S. 1~Clef. Agh, 4,j r. R eS. SCi, v,CC. f' Asrlct:lture Handbook No. 380 UNITED STATES DEPARTMENT-OF AGRICULTURE r.sud August 19io w.ift'.m, D.C. . Rtlgnt$ revised January 19:2
Page 504: wrm95d00
I CANCER--CAJSATION--I3X ENVIRONMENTAL FACTORS/ , Qt1MCALS--TOXICOLOGY~ ~POLLVfION CONTROL/ ASBESTOS/ TOBACCO--SHOKING--HEALTH EFFECT/OCCUPATIONAL DISEASES/F.NVIR()NMENTAL NEhLTH/ ~?TSERSES--CAUSES ~ND-,TH ORIES OF CAUSATION/hzItATINE--PIiA ~ OGy/NOISE/ POLLtRZON=-NOISE/ IR--P LLI]TIO*Ij ' ~ ' . . R!l 4b5 ~t AN U IN. r'16- 19 t T3 ~ - r . eat:ae M. SteIlman, Ph.D. Susan M. Daum, M.D. With Contributions by James L. Weeks, m.s. 9teven D. Stettman, YH.D. M'ichael E. Green, pH.n. -Vrith Musftatioas by Lyda Pola IS DANGEROUS _ TO YOUR HEALTH ~ A Handbook of Health Hazards in the Workplace and What You Can Do About Them YINTAGE BOOKS A Division of Random House. New York
Page 505: wrm95d00
RA 50335 3019 /CL:<<"_4TE/ WE.AT[:ER/ AGRTCUT.TitRE/ POLLt?TIi)N--AIR! 576 Utz /PuLLUTIO*T--WATER/ 1975 EFFECTS OF CHrO'NIC EXPO SURE TO LOl'V-LI+ VEE POLI.UT.t4.NTS Ih' 0 THE ENVNIOitiMENT PR PAFtE• b FUR 7'lIE SUBCO]MMITTEE ON THE ENVIRONMENT AND THE ATMOSPHERE ~ COMMITTEE ON SCIENCE AND TECHNOLOGY U.S. HOUSE OF REPRESEN TATIVES NINETY-FOURTH CONGRESS FIRST SESSION BY THE CONGRESSIONAL RESEARCH SERVICE NOl'E.IIBER 1975 LIBRARY OF C4NGRESS Se: ial 0
Page 506: wrm95d00
DISEASES--CAUSES AND THEORIES OF CAUSATTON/RESPIRATCIRY ORCANS--DISEt.S1::S/ CANCER--CAUSATION--BY EANIRON':~trNTAL FACTORS/WATER--POLLt,TION--HEALTIi 1:FFECT/ CADMIUM/SELENIUM/CARBON MO:30XIDE/SMOKING AND HEALTH/PESTICIDES- -\TO!:ICOLOGY/ RA 576 Wa 1973 HEALTH EFFECTS OF .ENVIRONrIENTAL POLLUTANTS By GEORGE L. WALDBOTT, M. D. The C . V . MOSBY COtg'ANY St. Louis 1973 316 PP.
Page 507: wrm95d00
'3 s Js t ~. P771 ~ / ~~4Qr~i ~ ~ 0 ~ ANNUAL LE ST Lc_ r ~'ICT7 0 1971 - 2/.S National Institute for Occupational Safety and Health . q;p 0 S 0 0(t 02ttSkYA ~r7O 2452 13 I U. S. DEPARThriEtJT OF HEALTH, EDUCATION, AND WELFARE Health Services znd Mental Health Administration National Institute for occjpatiunal Satcty and Heafth
Page 508: wrm95d00
Un5-y U. S. Occunational Safety & /alth Administration rnFRAL RE(;TSTF.R, ~ TUE~DAY, OCTOSi;E~ 4, 1977 1DENTIFICATiON, CLASSIFICATION PART V! AND REGULATION OF ~'-~- °~- ~, ~f.f9~POSING A Q E ' ~ ~~~~IT 0t POTE TiAL v~CCUPATtONAL tARCINOGENIC RISK ~ CtNOGENIC RISK Occupational SQfetjf and Health Administration
Page 509: wrm95d00
y Me„q -- -7 S" s,f 50335 3023 , INDUSTRY SURVEY OF TEST METHODS OF POTENTIAL IIELLTH HAZARD November U.S. Environmental Protection Agency Geoffrey Woodard, Ph.D.. Woodard Research Corporation 1974 Office of Toxic Substances This report has been reviewed by the Office of Toxic Substances, EPA, and 4pproved for publication. Approval does not signify that the contents necessarily reflect the views and policies of the Environmental Protection Agency, nor does mention of trade nar.ies or commercial products constitute endorsement or reco;.naendation for use.
Page 510: wrm95d00
50335 3009 AIR __POLLIlTION--HEAI.TH EFFECT/ENVIRONMENTAL AF.ALTfl/~-- ----~ Vapor-Phase Organic Pollutants - Volatile Hydrocarbons October 19.75 4, TITLE ANDSUeTITLE 0. RErORT DATE and Oxidation Products 1. HLP()RT NO. EPA-6oo/1-75-005 i6.-ERFORMING ORGANIZATION COOE 7. AUTHOR(S) Panel on Vapor-Phase Organic Pollutants !. PERFORMING ORGANIZATION NAME AND ADDRESS National Academy of Sciences National Research Council Com:aittee on Medical and Biologic Effects of Envi;onmen tal Pollutants, Washington, D.C. 12. SPONSORING AGENCY NAME AND ADDRESS Environmental Protection Agency Special Studies Staff Research Triangle Park, NC 27711 of nitrogen and sulfur are studied. 0500 00-25298'. ~/. PERFORMING ORGANIZATION REPORT NO. 10. PROGRAM ELEMENT NO. 1AA001 11. A . 68-02-05b2 13. TYPE OF REPORT AND PERIOD COVERED Final 14. SPONSORING AGENCY CODE EPA-ORD This re ort concerns va produced as p por phase substances likely to be community pollutants in sufficient amounts to affect health and well-being. ~ Sources of vapor-phase organic pollutants are listed) including collection and samplinEl techniques and analytical methods. Possible mechanisms of formation of oxygenated organic hydrocarbor, tompounds in the atmosphere and of atmospheric reactions of oxides 0 I
Page 511: wrm95d00
.. - _ _ . n'}.. L~i t_.i.. '3t;7;i 35, 0
Page 512: wrm95d00
` F" PURCHASE MYCOTOXINS `°~ IN HUMAN HEALTH I AFLWXIRS lTOXI CoIAGY I rANCER--CAUSATIOi4 BY AF.LATOXINS / • RMI ~ Yu SYMPOSIUM ON Edued by L ~ 116 The Proceedings of aapposium held in Pretoria from 2nd to 4th September 1970 under the auspices of tire uth African Medical Research Council with ~ collaboration of the South African Council for Scientific and Industrial Research. MACMILLAN - 071
Page 513: wrm95d00
50335 3025 TOBACCO--SMOKE--CARBON MONOXIDE/TOBACCG--SiiOKE--NITRC)SAMINES/ TOBACCO--S*1OKE--AIR POLLUTIJN/ CARBON MONOXIDE/I:vSECTS/RODENTS/ANI:MALS/HOUSING/OCCU,'ATION~.L T~ISEASFS/ CLItiATE/TRANSPORTATION/MENTAL HYGIENE . ARS1:?iI C; CADr+It'!f :/ LEAD/MERCURY/ASBESTOS/CARBON MONOXIDE/NITROGEN OXIDES/FLUORInES!ozoNr•./ NITRATES/NITRITES/DDT/INSECTICIDES--TOXICOLOGY/POLYCRLOP.INATED BIP};E\1-iLSi' TERATOGENS/?,OISE/LAWS AND LEGISLATIOH/CHROMOSO:EF ABERRATIONS/SANITATION/ ENVI RONMENTAL HEALTII / TOB ACCO=-SMOi:ING--HEALTH EFFE CT~( AIR--POLLUTION--HEALTH EFFECT/POLLUTIGN--ti~ATER/ NITRUSA.*fII7cS/ FOOD --CONTAMINATION/CANCER--CAUSATION--BY ENVIRONMENTAL FACTORS DISEASES--CAUSES AND :HEORIES OF CAUSATION/ ~ . t WORLD HEALTH ORGAMZATlON GETTEVA rm :' ~4S" Wo HEALTH HAZARDS ~ 1972 ~ ~ 2 c• OF - Prepaned by 100 specialists '' . . PDDL 1 C. THE HUMAN in 15 countries ~ Y y El, \ . IRONMLNT ~ CA fiL.SecO ~-~ ii bra-j ~ ~ ~ S~ i~ D 5 0 0 0 0 2
Page 514: wrm95d00
50335 3026 POISONS--LAW AND LEGISLATION/CHEMICAL INDUSTRIES--LAW AND I.EGISLATION--U.S./ LAWS AND LEGISLATION/ Editor i Control Act published by CRC PRi'SS, Inc. 18401 Cranwood Parka•ay • Clccetand, Ohio 44128 (ireQrgt'. Dominguez Director Government Relations Safety, Health, and Ecology Department Cl$A-GF1GY Corporation Ardsley, New York
Page 515: wrm95d00
50335 3029 ii"a,3.Cia Of Rse AppL.E,!-11 Te:d co'! n~7 W~d I~uat~S~2 ,ea.e Divir-ion 7; ~~.t{~~y T"a.'slXit~ano 2'}l-u. lIELT` Lr+til'sitis'~Vfa~ltii tiT i:11.1C STt1I:Ci:> sii AE3s 1959 70 po Butt©r•Rartha Scienti.fic P1zbLcatiane Lon3an ~ 10 5 3 1 8 os o ©00 1i
Page 516: wrm95d00
50335 3028 j QD ~ 121 I Imperial Chemical Industries, ltd. Analytical Chernists' Cammittee. The determination of toxic substances in air; a manual ol I. C. I. practice. Edited by N. Strafford, C. R. N. Strouts W. V. Stubbinga Cambridge 1Eng.] Hefffer 11956, 226 p. iilus. 28 cm. •Includes bibtiograpbp. 1. A1r-Ana]ysie. i. Strafford, Norman, ed. u. TiUe. zrt. TI[le Toxic subatances in air. r QD121.I5 /--, 543.7 Library of Congress 171 b6-3JU7
Page 517: wrm95d00
Y GU I DES AL MMIi0 RATORI ES--SAFETY .--DESIDN/~,'O: SAFE:- H/3;; C'hemical utage:~s, ~` I~ighty T't~xic Substances r M~:aS~SJ ~'`4~G ~TIC;IC ` RB NS~ A i.~ LII ~~'~.~ rcinQgens, ratonens and
Page 518: wrm95d00
U. S.ENVIRON!lENTAL PROTECTION AGENCY/LAWS & LBGISLATIOl4/ POLLUTION CONTROL/U. S.--LAWS & LEGISLATION/ SOLID WASTE DISPOSAL ACT/ WATER--POLLIITION/AIR--POLLUTION--LAWS/OCCUPATIONAL SAFETT b HEALTH!.,CT/ T 55 Ki 19781/ 97y ._..~~~...:~.. < ~, O``=rs Edited by Marsha',l Lee Miller Proceedings of the second annual Toxic Substances Control Conference December 8- 9, 1977, Washington, D.C.
Page 519: wrm95d00
191eIROHMF:11iAL HEALTH/AIR--PALLJTIOQ/FIATER--POLLCTIAN/WASTF TREA'[Tfr»ii, VfR.S.Z--7CC2/RIELIOGkAPf'Y.CO?..X:`Ii YASTE DISPOSliL, VOLS.I-RVI/POLLrTION CONTR(n.,VOLS. I--IOII«IASTE,IRDTISTRIAL CO,i.S I/R::4iRSE CS':OS;S.VOL.IV/ WATER Z'ttPJliMi'T, VOL. IV/TORICOLOGY--ACDTE TOICICITIES,VOLS.II,V--XIII~6i.S,II,V--XlII/ 1 To RECOMMENDED METHODS OF REDUCTION. NEiPTitALIZATION, REC07ERY, OR DISPOSAL iu "R OF HAZARDOUS WASTE. PreU9X-1-`-- n_S. ENVIRttNlIENTAL PROTECTION AGENCY. "" Eyff.S.OTTINCEUet ai. Auaust 1973 t` Yo1s.I-M Diatributed by: IT.S.DEP E, National Technical Inform. Serv. p tD-224SSI-PB-224595 ~ VOL. I. SUMMARY REPORT. ~ Va1,II. TOXICOLOGIC•=. SUMMARY oOL.ItI. DISPOSAL PROCESS DE.SCRIP'IIOtiS, ULTIMATE DISPOSAL, INCINERATION, AND PYROLYSIS PROCESSE: p 9OL.IF. DISPOSAL PROCESS D£SCRIPTIONS, BIOLOGICAL AND MISCELLANEOUS WASTE TREATMENT PROCESSES. hn YOL. •. DATIONAL DISPOSAL SITE CANDIDATE WASTE STRF.Att C0:4STITt7ENT PROFILE REPORTS, PESTICIDES AND CYANIDE COiSPOtJNDS. 4OT..VI. l1ATI6NAL DISPOSAL SITE CPIADIDATE WASTE STREAM CONSTITUENT PROFILE REPORTS, MERCURY, -1" ARSENIC, CHROMItM, AND CADMIi1M COMPOUNDS. V0'L.TII. ~NATIONAL DISPOSAL SITE CANDIDATE WASTE STREAM CONSIT[TENT PROFILE REPORTS, PROPELLANTS, Vt3L.RII. VOL. IZ. EXPLOSIVES AND WARFARE MATERIAL. !tATIONAL DISPOSAL SITE CANDIDATE WASTE STREAM CONSTITUENT PROFILE REPORTS, MISCELLANEOUS INORGANIC AND ORGANIC COt'POUNDS. 1tATI0NAL DISPOSAL SITE CANDIDATE WASTE STREAM (aONSTITUENT PROFILE REPORTS, t RADIOACTIVE MATERIALS. , 40LS. Z. IIiDrSTRIAL AND MUNICIPAL DISPOSAL CANDIDATE WASTE STREAM CONSTITUENT PROFILE REPORTS, & II. tAOLS.III. ORGANIC COMPOUNDS. INDUSTRIAL AND lIUNICIPAL DISPOSAL CANDIDATE WASTE STREAM CONSTITUENT PROFILE REPORTS , i IIII. INORGANIC COMPODNDS. , . aOi..M. SUMMARY OF WASTE ORIGINS, FORMS., AND QDAPITITIHS. VOL. XV. RESEARCH AND DEVELOPMENT PLANS, ~ KIL.Z'II. REFERENCES. •
Page 520: wrm95d00
Taxic Substanccs 1 ,~ Trademarks and Product Namec ~ Reported in Conjunction with 19J9 the. Chemical .Substance Initial Inventory Y-Reporting ~Company Section 0 5 o~d~tla4~~§ pt~d_ _ (i
Page 521: wrm95d00
50335 3039 III Meg-79 S.P. • U. S. Environmental protection Agency, Office of Toxic Sabsaances (WH-557). Washington, D C. November 1977 „ 0S 0 0 0 42 5336 11 - 1
Page 522: wrm95d00
5Q335 3031 Imperial Chemical Indnstries, ltd. d9uaZyticaZ Chemisu Cmnmittee. The determination of toxic substances in air; a manual of I. C. IL practice. Edited by N. Strafford, C. R. N. Strouts, W. V. Stubbings. Cambridge [Eng.] Heffer 11956, 226 p. inus. 23 cm. Includes bibliography. 1. Air--Analyate. z, StratYord, Norroan, ad, tr, Title, m. Title: Toxic substances In air. Library of Congrcge "10'' 171 0 5 0 0 ~ 0 2 5 3 ?. C~
Page 523: wrm95d00
50335 3024 . , =-= =-APPENDIX I -.XT CHEMISTRY, PRODUCTION, ~ p r fi~RONM~NTAL PROTECTION AGENCY AND TOXICITY ~ j. Doripn, B. Fuller and R. Dnff~ • . Otfiee of Air and Wastc Msn.6cment ~F ~.,,~~,~ rI ,,.,, . ~. ;., '~ Mitre Corporation Offios of Air Quality Planning and Standard. ~ ~j~"~ ~~iy~ . Metrek Dirision Rauuch Trian6le Park, North Groliw 27711 - . p~t;ate Research Park Octeber 1!?6 ATH,.1OUG11 L-- . . Pre .eal fa r 5 3 ~~ O S~f © 0 0 2 Is CREMICALS--TORICOLOG?/ L . AIR--POLLflTION--HEAl.TE# EFFECT/TORICOLOGI--ACUTE. TOXIC,ITT/ / EPA-450/3-77-008b f23 On PRELIMINARY SCORING 41076 I F SELECTED CDRGANIC AIR POLLUTANTS .~.__ p~ : 0T7I: Ahtsm Offiaer. David L Ps {
Page 524: wrm95d00
•-'Noise Control Act ~ •,Occupationai Safety and Health Act •y Clean Air Act (as amended through ~ • rResource Conservation and Recovery Act or November 1977.) c ~ ySolid Waste Disposal Act •Federai Water Pollution Control Act as ~ • Safe Drinking Water Act (as amended amended by the Clean Water Act of 19' ~ h November 1977) throu (plus amendments through November "9' ~ O g . 1978.) • - - ~-. •rNationai Environmental Policy Act LAWS & LBGISLATION/t•.ATER--POLLUTION--L*M/~ISOLID tdASTh/ ' AIR--I'OLLUTION--LA:JSi*IASTE nISPOSAL/ngvx%;' CT/ FEDERAL REGLTL.ATInNS/ T Ei~ ~l 1~iL'it~~~[~ 1 l~~ 55 GO 1979 STATUTES ~ GGovernment tnstitutes, Inc.
Page 525: wrm95d00
50335 303q LAIJS & LEOISLATIO`/ T 55 Co 1976 Law and Explanation . P. L. 94-469 October 11, 1976 CCH Editorial Staff Publication CaMM1ERCE. Ca.1EATiNG. ~.. ~\V.N\\\\\\\\\\\\\\\\\\\\\1\\\\~ \\\\\\ \\\ \\ \\ \\\\\\\ \\\\~ \\\\\\\\\\\\\\\\\\\\\\\ \\\ \N \\\\\ PYf1Lt6MEQS * ,f TOP/CAL LAW REPORTS 4025 W. PETERSQN AVE., CHICAGO, 1LLINOIS 60646 .
Page 526: wrm95d00
50335 3442 L III MeA5-79 S.P. The fREPDR ING FOR THE CHEMI L SUBSTANCE NVENTORY ..r Instructions for Reporting for the Initial Zn.uentory DECEMSER 1977 U.S. Environmental Protection Agency Office of Toxic Substances Washington, DC 20460 3 3 1
Page 527: wrm95d00
REF Q 123 Un 1979 I rr _ . .. .. T ~ ; .~ ._ . ~~~ip2 5 S29 tow VOLUME I INITIAL INVENTORY rog) - 50335 3040 VOLUME II USEIt GUIDE AND INDICES TO THE INITIAL INVENTORY SUBSTANCE NAME INDEX I`i 7 r VOLUME III USER GUIDE AND INDICES TO THE INITIAL INVENTORY SUBSTANCE NAME INDEX : yr,~,~.~ VOLUME IV USER GUIDE AND INDICES TO THE INITIAL INVENTORY MOLECULAR FORMULA AND UVCB INDICES ~ U.S. Fi-vironmental Protection Agency M'~ ~' ~ Office of Toxic Substahcxs Wash:ngton, D.C. 20460 May 1979
Page 528: wrm95d00
RJR CLASS NO. TEXTBOOK Q 123 Un Ref. Q 123 Un U.S. Environr+ental Protection Agency. . VOL. I. INITIAL INVENTORY. VOL. IT.-USER GUIDE AND INDICES TO THE INITIAL INVENTORY SUBSTANCE NAME INDEX. VOL. III. USER GUIDE AND INDICES TO THE INITIAL INVENTORY SUBSTANCE NAME INDEX. VOL. IV. USER GUIDE AND INDICES TO THE INITIAL INVENTORY MOLECULAR FORMULA AND UVCB INDICES. Ref. Q 123 Un - Vol. I-IV (1979); Cumulative Suppl. (July 1980); Cumulative Suppl. II (May 1982); Q 123 Un - Cumulative Suppl. II (May 1982) Cumulative Supplement II supersedes July 1980 Cumulative Supplement U.S. Environmental Protection Agency, Off. Toxic Substances. Washington, DC.79.(IN : ENG.) ISN = 3522
Page 529: wrm95d00
"It r- ~ 0 INDDSTRIAL BYGTENE/INDUSTRIAL TO7CICOLOGY / ;n, . _ WATEt -POLLUTION/SAFE DRINKING WATER ACT/PF.DERAL WATER POLLtTi'IO'c CONTROL ACT/ASBESTOS/CANCER--CAUSATION BY CHEMICALS/1AWS & LEGISLATION/ ~ ~ TOXIC SUBSTANCES CONTROL SOURCEBOOK. ~ 0 EDITORS h REP Alexander McRae Q The CerNer for Compliance Information 123 Leslie Whelchel Hc The Center for Comptiance Information 1978 CONSt/LTtNG EDITOR a Howard Rowland The Rowland Company Q 123 rse 1978 AiV ASPEN PUBUCATfON I Q S. 0 .0. 0 0 2 S 3 2 6 U. `S: -~-~ ~ ZEGISLATION/ OCCUPATXQNAL SMETY & FIP.A,LTg/ THE CENTER FOR COMPLIANCE INFORMATION
Page 530: wrm95d00
.j. .-.~ ~7 ~.~5. RTaLional Institute for Occupational Safety and Iiealth ~ U. S. DEPARTMiEhT OF HEALTH, EDUCATION. AND WELFARE • Health Services and t;~entat i;caf+.h hdnr'rlisir~tion National Institute tor 0 upr:ti0r ~~t Safety and Heaith osoooozS1 Rockviliv f.td. 2U$52 ---- - 0;q r.• ..._ r_ T~ ~
Page 531: wrm95d00
50335 3050 ; MeA4 ~ ~ (1968) 3 ~ Bar, T. ~ SITUATZO;i IN Ta5' IiYGI£idIC ASSF:SSt^.:Iii Or A-e,umukTIZATIatl AGEi3TS FOR FQOD ITk.idS, by T. Bar, s.na h. Gr+el er_tYog Aicd. Lrnahrun•g lx, 244-251 (1967) Q 5 4 Q ~ Q 2 5 3 3 9
Page 532: wrm95d00
SMOKING & HEALTH/TOBACC4--SNIOKING--PUBLIC/POLYVINVL CHLOitIDE/NITROGEN DIOXIDE/ ENVIRONMENI'AL Nt)NITflRING/STATISTICAL t#'THWMATHEMATICAL MODELS/ ~~TOXICflL06ICAL T€S`fIi~14aG ~ CVi06£xS S/ .~'Il ir~.~~IlI11E'r1C5'i 1: 576 ~ Un ,",. - S #e eIec ~~ P d avers., V. 3 'rois valu.e presents sevantasa "Sslact.d Papsrs" v~irh ~rsre given at ftdrirommstrics 81, & conference held ia Alexandria, `wiraia.a April 8- 10, 1M1. ibase papers describe a aumbsr of res.arr.h rssut ts iti areas s^alati,a% to .avironrental qnalitl trberR usth+rwatics' and statistics have }lq4d a slVif icast rols aod at the sa+rs tise dey of t*ii point to asv topics aaattift `'f'upste lpvssti;:tions. The papers are ia part sxpositary in aatase; It 3s 'iwpad that they Yill be useful to seraeatchers for f refarsnca sad d.t tbey tri11 wesrra at the sams tits as sm iattrolatation for tho4re afi0 ry iIR aratnci" t``~he iilld. Selsc~i+oos fham a Couberenw spanwrsa and up' ,wUd by 1160 U.S. ~1Y~1'011i~is~ p!'0teetba Ape~.'~ ~iac3~''fee hndutrial Imd:!l5pOied % t~~ ow !L8 'MM ;aaututs f0; iftsms- ~,IBM Am r.nm . .rr ~.r ~A. f - - - - - - - -- ~i61
Page 533: wrm95d00
50335 3041 ~, . T- 55 As AIR--POLLUTION--ANALYSIS/ WATER--POLLUTION--FQ:ASQREMENT/ -/?lt1TAGENICITI'/ American Chemical Society Toxic S~bstances Control Tapes :. (12 Cassette tapes) !73 44-#• ACS -ok t1wnODS FOR SESSNENT CfT7'1 -173 YiaJ-.~i~CS , ) VC~xICAL CARcg 3. x ~OC£xs (i 1?5)C164 ~ *~.t, /~CS 'O~ ," ~. - ~ ~~IORACxCAL £FFEC~SyOF._ENV_II.ONRi£NTAL .FOL'LUTANTS r (977 - i 74 ~•f rk ~ .rHOEQTORING TOXIC.YNDy RIAL SUBSTANCES (t 4 7 7 - ~l 7N t!~ n+a# A4C S M,aa~. • _.;.r._ _ VITRO TESTING FOR.CARCIHOGEbTS a MUZAGENS•(4,fk•+479) AMERICAl1 CHEWCAL SpaETY DSPwbv" 203 ~. ~I ilty~ r„ s. xw. ` n. D.c. 20036 -ftaa. eoo4244M i
Page 534: wrm95d00
INDDSIZIAL HiGIRiE/INDUSTRIAL TORICOLOGY/TqVC SIIBSTANCES CONTROL ACT/ `.,;. WATEB--POLLUTION/SAFE ftINRING WATER ACT/F80EltAL WATER POLLUTIOr; CONTIiOR. ACT/ASBESTOS/CANCER--CAUSATION BY CIMIICALS/IAWS & LEGISLATION/ Q 123 mc 1978 ,. EDITORs Alexander McRae The Center for Compliance Information Leslie Whelchel The Ctnter for Compliance lnbrmation CONSULTtNG EDrrQR Howard Rowland The Rowland Company U, ' S ` ZEGISLATION/ occ0PATToxu, S!lFETY & NZALTg/ , THE CENTER FOR ''~'~' ~ t ~~ COMPUANCF INFORMATION AN ASPEN PUBL-1CATION /
Page 535: wrm95d00
50335 3051 FOOD--CO,•:~'E.°•;IE:~CE/Pp,OTEP.'3S--P<tTTT:ITI~tT: ~'ALt?E/READI~'f: tT'.I"r.PSI'i i / FOOD--TOXIC.ANTS/HEALTH FOODS/FOOD--LAW AND LEGISLATIOt./ LAkt--FOOD/DIET--NLTRITION/ ' /FOt1I)---?IIETETIC/ FOOD--ADDI'1'II'I:S/S1'ACE FOODS/i~00D--NUTRI.TIO2 N %C ~'ji;S A:Z Ctt:iVLNTIONS/ ..NUTRITION/NATIONAL;COLLEGE OF FOOD TECHNOLOGY/NATURAL FOODS/ t F-E AND F ~ An Industry-t'ntversitv co-operation S.-posium organized under the auspices of the National College of Food Technology, University of Reading, on 27th and 28th Harch, 1972. Ediucdby, G. G. BIRCIi, L. F. GREEN, and L. G. PLASKETT A HALSTED PRESS BOOK ~ JOHN 1'VILEY & SONS ' New York-Toronto ~ / 77Z , .t as0 o0 0 2 5 3 4 0
Page 536: wrm95d00
Q 123 Un 1972 1PrIAYMWT SAFETR AND HEALTH fI Ti~E : THE _ - - - t 1 d• spolew R"rt 2 E 97 m ort s.Pfemb*r zo, 1972 Oauootiona! Safety and Meaii Ad I y' ~ ~ sdi i:flezbert E. Christensen&,m Saw6cn and Mefbt H*ahh A&mWjdw~ I q" 3 j MAowo~ trstavft for occupotional saf.h, ed r+eolu,,~ic~E~~'fIe 1ig 7~/-~c. PDOL ,c. ~ CaiMMT.'CLEARTiX fn$OUSE. .~i,.~«..W.,.....,.,.....,,,....~ ..r........,~.,,.,t.....~.,..+i •US/LAs..cws.f Tovtc..l L..w w:oowrs u~ U. 5. Department of tiealth, Educatiow mnd Welfare KCW YORK CHICAGO WASHINGTON
Page 537: wrm95d00
NORPIICOTIh'E, NT_TIBcOSO/ 'Pitle and Suutitl 4 . . 50335 3046 Suspected Gtarcinogens--A Subfile of the idiOSlt 7. Author;s) !{E Ch ri.s ensen . TT _ 1_~tw~inbyh]„ BS Ca,rKo11 5. Keport I)ate 6. 8. E'erlorming Organizat Nu. ~ 19. Per(orming Urganization Narne cnd Address acoT Jitco, Inc. 76 E. Jeffer.son S Rockville, Md. 20852 10. Projcct/7'ask l 11. Contract/Grant No. ICDC 99-74-92 12. Sponsoring Organization Name and Address 13. Type of Report & Pc: d ational Institute for 0ccupatioi:al_Safety and Health/CD'C/~ C°°ere I3l1Gw .`;S. PUBLICE HEALTH SERVICE,z"~~. c~ D~sec~as-~%t->~ 1 5600 F3. crs Lane j iq " , }tockviiic:, rSc: 20852 16. Abst:actS 1be publication is r.he fi rst of sr.vtral suj)T*i.] es' to t te N1ZSl1 ozi~c ~~ Substances File. For the purpose of this compilation, agents causing beign or malignant tumors are classed as ca_-cinogens. The objectives of this editior- is t
Page 538: wrm95d00
1 -- 50335 3054 TP 370 Ja 1972 FOOD- ADDITIVE$/ 1 The Consumer's Factbook of Food Additives AUCSAEL F. JACOBSON AN®M soors Dorrbleda3' & ComP=Y, Inc. Gardai City, New York 1972
Page 539: wrm95d00
~'~d 6ZZ vtqTO=0 xrplatg SCR i+Y a0 1:'nV L.4YUi.lV al),.Lm•Yls.i.t.."" 6b0E SEEOS
Page 540: wrm95d00
50335 3045 XX MeB5-78 S.P. . Naturally occurring Robert L. Gross, andr.Paul M. Newberne Nrrmerous chemical toxins, including normal components of natural foods, e.g., at)tt»taxins, and toxic chemicals as rnntmnnuints such as prsticides, ferlilizers. food additivrs, aml in-esrnwtii•rs. x0uch arr hnttntiall,v toxic to humans, are discwssed. Patrntial taricity, the hazard to nwn reprrsenJed by most of these chemicals, may be low because the concentration in food may be low. The gap in our knowledge of long-term effects makes rational decisions as to allowable kvds of these substances a major problem. On the other hand. nitrosamines and aflatoxins are toxins for which there exists a voluminous literature documenting extreme biologic activity ia tvrrimental animals and indirect evidence for activity in man. EpidemioJogic ewdence has linked them to kra>fan cancers, and because of increasing evidence of lwtg-term human exposure to these tozins either as inadvertent contaminants during food prryearation or as the metalx,lites of Nryc»tic infestation this possible ha-.Ard demands intenshY investigation. An exhaustive rrvlew of data from epidemiologic surveys In various parts of the world, as n•ell as from loWt rm jdqnmwry studies, ripresrats an ftttprtaaive start in this direction. w_..A a• !% it ~ :;:.. 050tl0A2 5 3 3
Page 541: wrm95d00
'EOOb--ADI}I TLM--DI RECTORZES /FCi€1D--FI,,A-VORA~T.T~5 /FLAVORAN2S--F-MD / CTI OSf.F.IES-7-03Di A CMPSMR°S DIC'TIQ`~°A1ZY CF FOOD ADDITiVES. Ings*dients 'harmful and desirable fouatd in packaged foads, . - .With. coaipLete 'iaforma_tioa far the consumer. $y =in WINTER Crown Publishers, Inc., New York , . 4
Page 542: wrm95d00
50335 3052 , t TP FISHING INDIISTRY/SALMONELLA/SANITATION/AFLATOXINS/ 370 Ch DISEASES --MI CROORGANI SMS /MICROBIOLOGY/ - 1973 M I CRZOSIAL SAFETY fssB::Am0T6FUY/ OF FISH"b'ERZY PRODUCTS Ed;ted br FISHESp-4I5EA5E50VD PESTS/ FOOD, FRO2EN--MICROBIOLOGY/ ~ H. D. GRAHAM ' _C, 0. CHICHESTER _ e D,rpnrtment o; Food Science Dsparhnerd of Dairy and Food Science aad Resource Chcmfstry Uninarity of Saskatchercan t'nirersity of Rhode Island ' Saal'.atoon, Saskateheuon, Cariada fiingston, Rhode Istand _. .1973 ACADEIIIIC PRESS New York and London '^a '
Page 543: wrm95d00
50335 3060 ~. S, !!lat~on¢1 ~clPn~l Sc~tpce5 ~. ~o..d ~roYeCtid aOX,cANrS occ,ol!lcTNa rOTUswtt.y .. . - - . _. gC,tGclS . NOf iA,n ~t RCSa4roh counCf./` t-y6i "3Myrutar 4 9 ~3 5 0 0 o 0 2 S3 3at pars
Page 544: wrm95d00
_ ..i ,`udQMF'Ot»Q .~ :;.~..~.......:..~.:...~:._..~.,,.......;~:...~:~.~.~s~.~.:;~..;~<:.~:: `40Oj ltt ovLwn--rjo StNY.3IXO1 eS4£ SEE05 r
Page 545: wrm95d00
XX rfel'-U-90-73 30 -Fi::.Is;: t•UFFS, March 26, 1973 50335 3053 f ~ (!3} ANRC P,-J-JI,S 1' ! "'a rZ t!I~D  ~~~~~~~~~~ ~~~ ~~ ~ ~CO: _ ~h-).A ~ D •~,; ' E~ ~ 1 • I !k ss~ ±q, r"'; 0 ~t !~~. F ! f4 ~'P c ~ •,^:.=` . ('..  /'q ~~ •w 5 li ~ ~~~ G.. w . ~ , L G ~L:~ ~`~ ~ o.. . ^, ii ~ ~ ~,~ e~t ' tJ ~` ~s s . ~ Not er:cubh is known about the effects of man's response to toxic elemer<<s to be complacent about current exposure. There also is a need to know more about the effects of nutrient deficiencies and ex- cesr^s as related to respons-c to toxic elements. By M. fF. S.::-Ocy Fox - Divi:icn of i:ut•iirn, Bcreau of Foods - Fa3~ ,`- rvrv_ a*rdnistrztion . .. .. ~ - , And he•:rn r,:, no:~a ~ lechr. ,-:i r_ ;Ecr. Evrczrs rf foods %- .
Page 546: wrm95d00
-~. -- .~... FOOI)--POISONIHG/FOOD--Ai!tt LYS IS /FOOD--Cn~ ITAMINATION/' - TOXICOLOGY-FWDS /NIT}LITES /TRACE ELEMENTS /MYCOTOXINS /TUMORS /CANCER--CALjSATION / ION1tY. RESEARCH COUNCIL, FOOD AND NUTRITION BOARD, CO!^1ITTEE ON FOOD PF.OTECTIC ~ TP 7• :7n u.. 37 I 47q ~ - - - j /&- D NATIONAL ACADEMY OF SCIENCES UsAin;ton, D.C. 1973 &PAAZA'"r 11 S'ECOND EDITION
Page 547: wrm95d00
50335 3057 xx MeA4 (1968) :ar, T. SITUATION IM THE IiYGIE1ZC !'zSSZSu?L;; tT OF ARGr1A2lZATIQN AGBPi i S FOE Fc*D ITEtiS. by T. Bar, aucd F. Griepentrog '121• Enna-hruug 11. 244-251 (1967)
Page 548: wrm95d00
-~ - ~~ Fatwdr buteadw. M UWoevft of C1+toago: Ftnt Aniska and IwW" Profewor. Deymemant of Espgrh~ afkr,obiotogy. Diayo Clinic .nd Fowidatba; Coearirsnk wdtsr Rm.d Arwy Imtitute of Ruearcb, Ws"VV% D. C.; LscWrsr. U.S. Public H.a&h Service. C.D.C. ?mtniag Bmwi, Adanft IlsmSs . Liotws .nd Sdaxdk AdoiwrV Board of the ~_ QwWrmadw Food and Contana Iaaihmr for the Armed Farss CHARLES C THOMAS • PUBLISHER SpiWW • Dtilk* • US.d. 4
Page 549: wrm95d00
RA 1230 Ae 1973 S0335 3068 /FREONS--TOXICITY/ FLDOROCARBONS/ COAL TAR/ /CANCER-CAUSATION/ CARBON MONOXIDE/ MACROPHAGES/ /RYDRAZINE DERIVATIVES/ AIR--POLLUTION/ CANCER--AIR POLLUTION/ PROCEEDINGS OF THE FOURTH ANNUAL CONFERENCE oN NYIRONMENTAL TOXICOLOGY HELD AT FAIRBORN,.OHIO 16, 11; AND 18 OCTOBER 1973 , AEROSPACE MEDICAL RESEARCH LABORATORY aational Technical Information Service U. S. DEPARTLIEUT OF COMMERCE I 05.0 0 0 02 535:7 '
Page 550: wrm95d00
50335 3063 i~T, T4'~ Oman g.AC~:~~.51 ~u rT.r'JyJNG t.rIJ ?L;AL'i'H1 'TO 12 yr•~ Tsc.G.> {;Ts f ll/i 17) :.
Page 551: wrm95d00
t AIR--PaLIATION--AAAL?SIS/ WATER- lOLLUTIQN--MP'.AStfMM/ •IMUTACffitICI2?/ Asricaa Chaaical Society Ts 55 . (12 Cassette tapes) 11rouC sussrMICq>QVXWAc:r: ovsMW(rq73 j 4Lrz=s s FOR SESSH3MU477 - t'T0= ~ 4f vin5)(+wk !t* ~-OUacAZ. cAR wMwcAw dEWCAL SOCEff t11epM~ 203 JYMAItMIMo Slrew. N.MI. ~ul~rqlon, O.C. 20036 P11os! ~00~4•i747 rBIt~WCICAL EF~~OF~•Yt01~!!SN?AL °P~.Ltfl`Al1't'S f tq7 3 -~r7 ~~# llCS~ ' ."MMITORI_NG TOiCIC.'Il!iD SOBSTAliCEB 0 4 72 _17`~ #c 5+~+.i~.~ +0' ~ 'tE32.IM 6cARCiWMs & - ,~3~A~ts {s+e•r+t'79)
Page 552: wrm95d00
,:Cy~;~:,z~ q, ,.e y {:~i-1I3 t rT aa Sa ,~ ~pl ~;f ~ ;01 •sslrarn-axa swqvz Z90E SEEOS
Page 553: wrm95d00
salasbury. wi>>shtre, Fnglana (Reedrnl 14141aab 1969; arcepted 22 April 1969) . . _..,.~.. -. _.._ .t rb.nnaoobq, Vot.1t, pP 2145-2112. Patamoa Pras. 19fA. Prlnud In Onat Brttat. '' ~ ~ MODIFICATION Or NICOTINE~~~.~~ BY ° ' PRETREATMENT ~~ DIFFERENT DRUGS . ..~~ • B. C. B~xR~ss, J. W. BLACKBURN, R. W. BRIafBLECOMBE and P. Rtct>Y • Chtxnial Defenoe Experimental Establishment, Porton Down, Abstnet-Sub-lethal doses of nicotine have been shown to protect mice from the kthaT effects of subsequently administered doses of the same drug. The evidence suggests that a metabolic product of nicotine is responsible for the protective action. In an attempt to identify this mctaboiite it was shown that cotinine had no protective ution but that nicotine N-oxide and also the reduction orndur+ rf 50 335 . 3070
Page 554: wrm95d00
50335 3069 ' 262 A Albert, Adrien, 1907- Selectivee toxicity. 12d ed. rev. and resetj London, 11te thuen; 'New York, Wiley 11960] 233 p. illus. 23 cm. Includes bibliography. 1. Chemotherapy. 2. I'hyrtologicnl ehemtstry. 3. Drugs-Fbys logtcnl clTect. j. TEtlc. tt. Title:'1'oxfrlty% 1I111242.A5 1960 Ltlirn ry af f_'.rmgrefiK Q 5 0 b 0 0 2 S 35 8 615.7 60 ---421 i ~ 1ft1s^ll,
Page 555: wrm95d00
50335 3072 . ~ Aiam u+rrpHri. Val. 17, ". 1I1-1S7. Tergamow Treu 1974. Trimed in Grwr 8riuin ~ ....~._...-- ~..i'~-a.~f' © P. C. BowEs .....r rr.. &ulding itaearch EstabGshment, Fire Research Stasion, tiorehamwood, Herts' WD6 2QL ~~536! Q5 0 ~f0 0 XXIt 7J S. SM4KE AND HAZARDS OF PLASTICS IN FIRC
Page 556: wrm95d00
50335 3{367 Hi4 {._g~~ ~'ic s'nt``1 ~`~.7`"'"ia'~. 7(~a ~ ^ ~ e~I';'~ ~~ 07 TIM C~~"TIC:'tL ~ ~v 1 Cc lYb~~'~' t3'~ Da L0 <_ flu~r~~ ~'.c3. Sci. (1947)
Page 557: wrm95d00
~~CI2i~~i~~i ' b 8ti,t~ I~r'~t 5~i E~ U 0 0~ 0 ~'r~+a!.t~b~.ts!a!wtTb~ -9n~ti ~rnrv ~tao~,~°w~-~~oo~ 1Gbl aood/s-wv!w.9#7 a5F o1-E d..L . ._.v~,.,. ~..>: - . LtOE S££OS
Page 558: wrm95d00
50335 3074 -11 XXII MeBB 77 FIRE TOXICOLOGY: METHODS FOR EVALUATION S . P OF -~PYROLYSIS AND COMBUSTION PRODUCTS Report No. 2 A Report Prepared by the Committee on Fire Toxicology Under the Auspices of the Committee on Toxicology Assembly of Life Sciences National Research Council M,S. National Academy of Sciences . Washington, D.C.
Page 559: wrm95d00
50335 3061 f l ~ III MeA7-81 S.P. Mohiv fur Tusikokwiu, bll, 7C{6--3i1 ~1YBi) _ TOXICITY OF METHYLISOCYANTE AND ITS QUANTITATIVE DETERMINATION I1ar'dbL 7A".0wdwu nud l;nwwiwhyakigwiwn Lwtatut dar /+.rLwsfrbrikvu i liay.rr AC, Werk Wuppertal•klberisW (Leiter: PW. Lr. amd. l;. HtocuT) Voa Gt. Yirrtsswc mMi A.RrjcN llit 2 T"tsLLildunpn (Riapeyawpsn s S. lAikbrr liki3) In den letxtan aakran hsLen aliphati.ohe ural vor albm aromatirobe Isooyanate aine groBe techniwc4e Bexlautung ge+wonnon. $ie v.erden in gro8m Aurmalie in der LwlciadwArie, (lumntiindtsstris und bei der Harateiltuig vun Sohawnodotfon verwwodet. Bui iWm Verarbeiturg rind ~rencllieitiiaite BchittAgungen vorgelcwnman. Die.e seigten rich nsch ~ Ia6slatioa dierer Produkto ab Rsixtwg der Atmunguorgrne (Broaulitrrb, . J, Pnenmanie, A.thms brc,nchiaie-ibnlidie Znrtau&) und durch primare ' 8dsiden der Haut und .rrderen Buhleimbnutan bei direktem Kontakt. ..-....~.~___....~..___ ---- --- t~S00OQ2 5~9 0
Page 560: wrm95d00
50335 3032 'f~ felo /y77 III Ae9-77 Rederal Register, vol. 4F2, t3o, 46, k'ed., March 9, 1977 S.P. •PROPOSED itULFS CFR Part 700, 710 ] J •~i' +~~+'i Fs• Comments must be received on ~REG ~~~ will(ann~ounce th e exact ~ ~ orbeforeMay 9,1977. IOTS-e81~i FRi.. 690-5 -_ ': : " . . , • . • . . l ` ' FOR F'QRTHER INFORMATION CON- -s .~~LL: ATPAOACR ~ - ? "l Ift CA1rBIDArl LIS2 APPAOA .i ~ ' ! ACT ~ •• ~ . " r ~ . ~: ~ CR , : - i Geriera! Provisrons and Invento - Shortly. 'sfter publicaion of these pro- Kelly or George Scineniuk ry~, . Cynthia C ' , . , . ,• ~ Reporty~g Reguirements =.•.:. 0ffice of Toxic Substances (WH-557), posed reguIations, EPA will publish In ~ - 4 AC3ENCY:•Office of Toxic Substances.:;:FnvironmentalProtectionAgency.401 -.the`PznEeALRECISrsR a.notice of avail- u•~vfronuielital Protection Agency" J .- -;jm Street SW.. Washington, D.C. 20460 abilityt of a candidate 'list of approxi- (202-755-4380).' , mately 30.000 chemical substances com- =ACTION: Proposed'rules-pursuant to the:r-, autbority of section 8(a l; The Toxic Sub- SUPPLEMENTARY -- IrII'ORMATION • pued f rom various sovernmentaal " and- stanoes Control Act (Pub. L. 94-Jl69' '15 On December 29, 1976, the Biivironmen- pMvate sources' The sole purpose of this ~ ~ndidate lfst is to'simplify reporting by II.S.C. 2601. et seq., hereinafter referred tal Pr•otection-ARency (EPA) announced $i'the Fsn2RAL REGISTER (41 PR 56688) listing these chemicaI substances with dodethe formation of a'arork group to Im- e numbers--to be used in reporting 6OMMARY: These proposed regulations~ lement the~premarket notification and ~ ~Aem.' j~. ~pould establish a new 40 CFR Part 700 p rer must 'report on EPA ,Imd 710). Part 700, General Provisioas; mventory sections of the • Toxic Sub- " forma (for chemica~ sus nccs'on the ~ wotlld prescribe the scope bf the -rules stances Control Act (TSCA). Earlier, on -Candidats list) or on EPA form B(for I lpider TSCA and definitions applicable Dftember 7. 1976. EPA published In the all other chtmical substances) all"c1~ei~ ba sueh .rules. Part 710, inventory Re- ~aEw1L RECUTER (41 FR 53567) a list -~1 'atibstances he• has manufacture~_ 'porttng, would prescribe what chemical.~ Issues concerning implementation of f c6r'" a~ciai the: ct. At- a pubiic meeting held in ~05~ c austy _subatanc_es must•be reported for inclus- i;.,y~7. Manufac urers and processors iagton, D.G. on December 14~ and sbn on an _inventory of-~ctierMcal sub~•- may report on these forms other chemi- 3fianbes required - by section 8(b) of M• 1976,. representatives- frorri " indus,iry,- cal substances manufactured or proc- ,TSCA: procedures for reporting-chemicai lhbOr. and environmental groups "were essed for commercial purposes since July .Wbstances for theinventory; exemptSonsWited to comment publicly on these Ss- -1:-1974. CbLemicitLsube_t•,r.rPe ahich are •teoai such reporting re0uirenients and~' Silu e that time, the worL graup natap&tPd will not be included on the ?peztain prohibitions; *nd ures forem premarket notification has•met with Inventory of existing chemicals and be= . 1andislRelaimA f,~~~ L~0, 4~ of~e s~ te~s ts in the prep- . gi~fng in TlwnnlnhnLt Q77 will be subject ...... . . - ><7 'T"- ~iT-• ~ OC . th~e pl'opo8ed regulations. to Prour+ A *i:"'f hatif+catia~eQuirements .. . ;~$PA srill be holding another public rbnr+ -----•j--- ---- -- -_-
Page 561: wrm95d00
: 1tl : ~. ;PAW ~.. ' ~1'.~ S. A. .. Aerosol Tissue Adhesive Spray ~ IL Fate of ~~o.tI-N and Their Acute Topical and Systemic~ ¢ LTC Teruo Nefsunwto, MC, USA; K. C. Pani, MD; LTC John J. Kowric, M~ t~SA; and COL Harold F. HamiFt, MC, U ~ ' ROSOL tissue-ad.b~ve spray devel- t~'aahin,gton, DC - at this InAitute and by G. Harr Cama- patry, Niles, Iii, has been used suceessfully in V1etnam for hemostasis of otherwise fatal hemorrhage from liver and hidney wounds and for .reinforcement of suture lines of vas- A1Tsn. rc»vsire osrI . nnnweEwse.fa.we 0 5 0 0 0 0 2 5 3 6 5
Page 562: wrm95d00
ACTIVATION OF EXPER AL AND CLINICAL OLOGIC DISEASES BY X-IRRIDATION AND KYLATING AGENTS/ EFF'ECT OF DRUGS ON DRUG-Ip'~ABOLIZING S/ DRUG-INDUCED CHANGES IN,§TEROID.MET9B(fLISM/ METABOLISM OF DRUGS IN RELATION T0ACARC ENICITY/ RELATIONSHIP OF DRUG METABOLISM Wr OGLOBIN/ EMBRYOLOGICAL CONSIDERATIONS INr'S.'ERATOLOGY/ ANNALS OF THEvNEW YORK ACADEMY OF SCIENCES VOt,tME 123, AsT.1 Pe,GFS 1 346 March 12, 1965 Edk°'r . llenoging Editor HARota E. Wxmrtt,E RM 300 E{rALUaTTO1V M'D MEQiANI311SS OF6RU G Ne 1965 Conference Chairman J. J. Btnws vtrr I. Sr
Page 563: wrm95d00
$IOLOCICAL CHEMISTRY--WEOISlIxOPES/ PHTEiALATE ESTERS / PACKAGING--J1ATEBIA& 74 II Na. 011711-1-P i/ .....f U n l1 Y 11 Accumulation, '~~;-^and Metabolism of Common Plasticizers in .Human.c . Annual Report Under contract with: 'Contract No. NHLF-7-3-2-936-B Bethesda, Maryland October 1973 EDWARD A. NAPIER, JR. THE UNIVERSITY OF MICHIGAN MEDICAL SCHOOL Department of Biological Chemistry U.S. Department of Health, Education, and Welfare ,- U.S. Public Health Service National Heart and Lung Institute ~ } vepartment ot tslotog4cat t;nemistry (/•j '~ ~,~,'.~'/, /~ .,..~..~...r-:'A-l~.1`-. . . .. , . .. . '
Page 564: wrm95d00
Underwriters' Laboratories' Report on THE COMP.'-~.R ATIVE LIFE, FIRE, AND EXPLOSION HAZARDS OF COMMON REFRIGERANTS Including Ammonia, Butane, Carbon Dioxide, Dichlorethylene, Dichlorodifluoro- methane known as "Freon" ("Kinetic No. 12", also "F-12"), Dichloro- tetrafluoroethane ("F-114"), Ethane, Ethyl Bromide, Ethyl Chloride, Methyl Bromide, Methyl Chloride, Methyl Formate, Methylene Chloride, Monofluorotrichloromethane ("F-.i 1"), Propane, Sulphur Dioxide, and for comparative test purposes Carbon Tetrachloride and Chloroform. 0 S Q_ Q 0tl 2i5 ,t3 , b_4y
Page 565: wrm95d00
aAz`;~°'1 i gjG~ ~au~f •1, ~~ s.o„:O*to.Y .trl2r 1&. ~ ~yf r f y , 1. ;( S .Nf . ~ "rfnr Ant {~rvr;4 j-..- - e ~ L!~ ?tTtttionul ~uxn'~ uf ~irr 3(tulrrturiicr5 ~ /Z 207 EAST OHIO Sl REET. CHICAGO -9 i Report on THE COMPARATIVE LIFE, FIRE, AND EXPLOSION HAZARDS OF IF j&P.RTBj~j~~~~~~~IE t«FRE4N-113") ©~~c~ -
Page 566: wrm95d00
50335 30e1 U • . .E FI~ Influence of Varion by Paul F&I . Newberrze- 11 Ci~~~unicity{s and the Waaft!). ~~~~~~~it'.~, ~~ l ` " ~ l Co~~c~~~~ons°. ~ d ~ ~,'- MASSAGIkJSET'ESFNISTI, TUTE , T ~ (,T~. %{ ~~.,~V INDUSTRIAL LIAISON M Toxicologic diseases of man and animals, associated with molds growing on foods, have been recognized for centuries. Only in recent years, however, have these mycotoxicoses received the attention of niany laboratories and skilled sClCnti£(s around the world in a broad inter- 'disciplinary effort. This, review cove,rs the literaturee on mycotoxicoses but centers on those about which most is known, particularly the diseases associated with metabolites elaborated by some strains of Aspergelli, PenicilIia, Ficsarfa, Stachy6otrye, and CIaL•iceps. - The ubiquitous nature of the aflatoxins, toxic rnetabolites produced by Aspergiflus flarus, make them important to public health, especially since it is now known that certain areas of A=5Err.- .0 0 5 0 0 0 0 2 5 3 7 0 -1-
Page 567: wrm95d00
50335 3083 otzrien, F~. D. {®d.; S: C.C.4"Mb..a :i3XICGLOGt OF rVSE",."~ECi~ES,~ECi~ES, by R. D. 0fft3on aad Yxnru Yam=ot•a 19i0 218 Pages fcrdsmic Press New York
Page 568: wrm95d00
cD '~ Vi VJEI~ OCJCItkMN€!RT7 aaOL"Glia7 Loa 1Z.i~.k:;7c~fi A.mas • x • 0 i munb ~..~w..r. 980£ S££OS
Page 569: wrm95d00
. 50335 3089 CAR$ON MONOXIDE/HSCDROGEN CYANIDE/ III Me9 76 Study of the acute ~ of major toxicants produced during combustion S. P. ~_ _or pyrolysis of materials. by R. TRUHAUT, C. BOLTD£NE and J. M. JOUANY (Paris) A/ter considering the various possibilities of study of the toxicity of combustion and pyrolysis products o f materials, we have chosen to look at the symploms and mechanisms of the inloxicalions (30 minutes) and the events happening during the recoveries of two ontmal species, rats and rabbits. The first step was to appreciate, in our own laboratory experiments, the risks induced by the major toxicants which can be involved in pyrolysis and combustion products, lhat is CO, COs with and without lack of O,, HCi and HCN. 1'eoo kinds of intoxications have been set up : e in spontaneous ventilation, rats have been intoxicated in restraining tubes and rabbits in mask-cages. LC„ have been determined and the action of lozleants has been mainly observed on the respiratory system. Long term recoveries have been checked; . in controlled ventilation, the amount of tosicartl going to the pulmonary alckola .fs nWll known. Vigil, curari:ed and locally cuuslheti_ed rabbits arti ficiully ventilated have been used. Under lhe action of various amounts o f toxic ga:es, 0 500 00-25378
Page 570: wrm95d00
'7s 50335 3091 FEDER AL A,, ACTflT3 SE1ECTE0 ~~I G ~a C3~~ VO6.UG`v~1- CEALS. U.S. EHVIROMiaENTAI PROTECTION A6EiiCY FEBRUARY 1975 _.,. .,~ ~. ~, s Office of Toxic Substance Washington, D.C. 20460 9@, -560/4-75-001 EPA 0 500 0 8 2 5 3 8 0
Page 571: wrm95d00
-n .SlYeL~.1` • ...~,e...e.._ .c-~r.~... Yw.....~ +...- ...~...~... :..- . ..~ .._- . ~_ ~. .. . . . . .-:d . ~... , A• r pOtr&4-#-,/ j4'r NO . , Preli*fjnary Environmental &zard Assessvaent of Chlorinated . November 1973 V 1. Repost No. EPA-550/2-74-001 . PB 238 07 Ic swd Soscide Q S. •Report Dste . ~taphthaienes, '~ icoaes, Fiuorocarboas, Beazeae~ycarhoxy- 6. ~ lates and Chlo~"o henols ~ !. Ast~(s) T~pe of Rcpoct 8: Period Philip H. ~loWard & Patrick 8. Durkia • Ce,eeed . ^, !. Petfoneis~ Octssisatios Name swd Address ~t-er~m ~ Syracuse University Research Corporation ,~~TIONAt TECHNICAL ~ Merrill Zaue, University ~ghta "- ORMATIQN SfRYiCf - ~ Syracuse, New York, 13210 ~, jj*&O~,;; ,, ,; 1Z Spossoci.g Oe jssisatioa- t,ia.e asd Address 0 .:. ,. ,... ... . K.,,,. A reviev of five c~.asses of chemical compouads covering production, environ- 's3ental exposure, environmental effects, health effects, and toxicology. The b- classes covered are, benzeaepolycAIrboxylates (including _phthalates).__chlorinatpd ~0~a-0 4
Page 572: wrm95d00
`S"<f- -Y.~T•`T. , .s ii Z60E SEEOS - ,.
Page 573: wrm95d00
t B. BEYS, J. DuFAux et F. PMMaFF Toxicitr of lbwearbons - Aerosd lropenants Jttest of tAre Aieorotarboes Msed as proprlfanrs in the .wosals irt roxir. Studies rwtdatted ar difjernrt anfmal yrerirs allaa to toadize tlie es'ects priacipally at tke C.%aovawx&ir lteael. Amame Ov twast Iowiom lrradxcts, re may elss7p tbe lrroa iJ. ridrWwsd sxd proy+eUant- re duH drrort fwzlefty, rnvtrid be adJed wa kag-tw= - dmqw of depietta+r of tke itrnte*kerlc e:ome loyer. Js j.aMt eJ'" dwdle learard, tdOr.rtkars adodc+ate tlre Vadwe! ^%we*W ojlMox prvdreti a+.d tkeir rtpfoerweeiet ty rar tor.lars OwtemS. 7AW p.opos&ive ~ts.,t~c, ~nts ~po~&ioa or ~iow .lr~ro~y eisicertedlK sc.ranor cvawtrlss. w Zat de &nes particuies solidcs ou liquides. II s'agit d'un sysene dispers6 oiu Ia phase dis- persaaft est taxcuse et ou Ia phase dispersce est liquide on solide, Ia pariiculcs &ant suflisam- mantpdites pour rester longtemps en suspension. Ces particules sont soumises a 1'action de Sver= forces dont Is pesanteur et le mouve- ment browaiert. Les.Eroiolssitards sont des suspensions dans I'air, de pzrt&itles hqufdes, par exempie, ies atsages, dont k diamitre des micelles se situe aux taviroars de IOQ-d00 pm, les brouillards, de diamftc de mice3ks de 2 1 15 Km, ou dc pwtiades sal&les, tels Its nuages de poussiitres ou m&me ks ium6es diverses, dont Ie diamctre de laicelies peut descendre jusqu'A 0,2 jtm, et qu constitornt, en queique sorte, la transition ver
Page 574: wrm95d00
dichlorotet fluo oethaae (1) ~ ry ~. Toxicite aittne ct chroniaueA fno~ inea P G. PAULET et S. DESBROUSSES (Renaft)- Le dichlorotEtrafluorodthane porte dans la sdrie des carbures chlorofluoids le numFro 114 et nous le nommerons : iluorane 114 on F 114. Poss6dant les prorridtes g4ndrales des fluoranes, son point d'dbullition relative- tnent elcrd (+ 3,G0C) le rend particulibrement int6ressant pour la production locale du froid (ou 11 pourrait remplacer le chlorure (!',ethyle) et commc pulseur d'a@rosol. Le F 114 existe sous deux formes qut ont des propriCtds tosicologiques symi- ariqucs ! F= Cl C - C Cl F,, as),mdtrkguc : F, C - C Cl, F, extr6mement voisines. La toxicitE pour le chien et le cobaye a ctA- rechpM)•A- ---- "' Patty : 200 000 nnm -. 9 1- ---
Page 575: wrm95d00
41.1"Za/ 100' _ ~, &W~o A.,~ /;d": . ~./ - ._ ~ i ~~r~~ ~ , ~... ~~~:-) ~~~ ~ ~ ~ ~ ~~ s• Prepared by~c~uncit on Environmental Quality April 1971 0 5 0 0 0.0 2 5 3-7 9
Page 576: wrm95d00
I Fr3n Karolinska institutets hygicniska institution. . Freon som orsak till fbrgiftningsfall ~ AY Docent Tore Allhemrr, Stockholm. . Summary FICOtr ert BCdlljt o f IMNINIPMV freon as the ejecting gas. of the possible formation of phosgene by the use Qf spray packings with of phosgcnc poisoning, one of them fatal, arc described. Examples are given of the disintegration products which are formed at an open flame. Two cases Freon gases are discussed as regards their own xicity and also the toxicity Litteratur a) Iriucirolls, A. H.: Underwritei s Isborstories, AfisceIlanous Hazarl. No. i37S. I933• a) Ssyers, R. R.: US. Bureau of Mines, Report Investigation ;otl, z9.'.*. 3) Tandbcrg, J.: Tehnisk Tidsl•rift, h5fte 7, sid. 33. s939• 4) L/endetoff, J.: Aocti. Ind. Hyg. Oce. Aied.6, sr$. I95a• _. 11
Page 577: wrm95d00
50335 3095 QD ~ 549 ° Sa ~ - _ . _ ._ . . . ' t., Stii.u V.^,:Y ai?s4diiL'.i; 'veS+7 Yt1.ii t.as~L_t1 ~.Ci GJ.
Page 578: wrm95d00
50335 3094 T ~ 55 ~ Wo I :dorld llea2th CrgauiuAtion, Ir.te:n=n`jonaZ t.-sbour Office, Cc^:uzilte,„ on iscc:upaefon;E1 Health :~: ~,_,.,.'[..,u,3,,[: . . !.t....t ..s.~Jl.a.:f UC dU1lI~+ JUJ: 3.:a.icl.L,:? IN T?tE ::?RKItiCr Sistls Sc.is<<:n vf ttce Joi:iC IL.O/;:it43 CoIr.Tsiittce on Occugao.ioual_ il,ea;,Gh, Cc=.yva, 4-S U, 1.963 :.9b8 405 ?agPc
Page 579: wrm95d00
50335 3097 CHEMICALS--SAFETY MEASURES/SAFETY GUIDES SOL9ENTS--SAFETY flAZARDS/SY'NONYMS/POLLIITION CONTROL/ VINYL CHLORIDE/ / 0 REF Q 123 Ba 1975 I 'Baskin, A. David (editor) HANDLING GUIDE FOR POTENTIALLY HAZARDOUS MATERIALS. Published by: MATERIAL MANAGEMENT AND SAFETY", INC., Lake Shore Drive, Chicago 1975
Page 580: wrm95d00
FLAVORANTS--FOOD/FOOD--FLAVORAAITS/':._. /ORCANIC ACIDS/ AMINO ACIDS/ .. _ .M _- _ ,. . .~. _ s... _. __..,.::_: ._ . ._ ._ . . ... - _ .. _... •~'~it,rJusqi mtains a a~leietiaa Of data tnm te pAWshsd literatWe froft MM 10 do$. -tgaNst+ed btta from pdwti %&qfty i8a m also metai+ned in the mono- «*Mi-. .1UM44ta aovae tht apeailte ~notQ of strwtwIIYi~atated edmgounds -desigirtted in .`fl~1 ~. Ie~O~rd In this eMnitew4n dtta aa tmrielty a+sd meRaDotisna, usage and natura2 aNereee.in taodt, aad +'ao+upostti%al apeoffleatia+s. 'tW is a I3S p@p rerlew contafaft ~~. . . . . , ~ ~:~' ~ ~ ~ ~ •~' + ~:y Scientific Literature Review of Atiphatic Keto- and _..:... Nydroxy.AZids with Nonadjacent Oxygen Functions and PS 296011 Related Compounds in Flavor Usage. First Supptement ,,~~ 1 '~ - W9 1979 introduction and Summary, Tables of Data, -&P•- d ' es W4,„,,,,,,,,..,.;,, iography and Copies of Arti Bib1 ~ R~wr.+ e o~r.w.~ w.^. .s ~...~. ti. -wwnw~wa u,. w. fbrer ad FxtrW I+nufacturerx' Ass"in of tke ift oftamma .. omoeia «r. ~ Mt~sttln~, OC"F rna-q4-sss4 ~ - ~aNed Sistas , R~` r!' ~. . -- »
Page 581: wrm95d00
; Fluorocarbon Aerosol Propellants VI: Interspecies Differences in o u i i ies in 1.ggpd and Pha,~na and Their Possible Implications in tudies 7 s s P. SARFARAZ NIAZI and WIN L. CHIOU = Abstract t] Solubilities of the three most commonly used fluoro- carbon aerosol propellants were determined in the blood and plas-' taa of humans, monkeys, dogs, rats, and mice. Differences as large •s -fourfold in blood and more than 33-fold in plasma were found is different species. The partitioning of fluorocarbons between blood calls and plasma showed even greater differences between spaeiet An indirect method was suggested for the calculation of polsma concentrations from total blood concentrations. A compar ative evaluation was reported for the nonprotein bound fractions of fluorocarbons in the blood sampte's of various species. A correla- tion was drawn for the pharmacokinetic propeities of the fluoro- carbons.rithin and between species, and a_ntionale was provided tor the extrapolation of toxicity data from animals to humans. Re"hrases o Fluaroearbon aerosol _ propellants-Qnterspecies the gaseous phase at the equilibrium state (19, `_' Such a.ratio is, in fact, identical to the partition o-, ficient, P, between the two phases, as used con v tionally for nonvolatile compounds between org::: and aqueous phases. The purpose of this paper i-t report the results of a study on the solubilities of ; three most commonly used fluorocarbon prupellr,:: in the blood and plasma of various species. The pu. blc correlation between the solubilities and the pi- macokinetic properties and a rationale for extrap; : tion of animal toxicity data to humans also will discussed.
Page 582: wrm95d00
A 50335 3096 T 55 An 1975 2c. /VINYL COMPOUNDS/ VINYL POLYMERS/ ANNALS OF T11E NEWYORI: ACADEMY OF SCIEhCI_S VOLUME 2-,1.f January 31, 1975 TOXICITY OF VINYL ClILO3iIDE-POLYVIN1'L CIILOIZI1K Editors and Conference Chairmorr IRYING J. SLLII:OFF AND E. CUYLER HAMMOND 5 3 8 5 0 5 0 0 ~ 0 2
Page 583: wrm95d00
:.. 50335 3087 a 39 Js l ~ 97 i.. 7 2 i!, /ZG-7.(M> ASURENMN'I' OF4aWTION OF AEROSOLS IN SNML LABORATO AALS K. SACHSSE, L ULLMANN. G. VOSS* and R. HESS ReKarch Departtnent, Phannaceuticals Division, Ciba-Geigy Ltd, Basle, Switzerland .- Ttte only availabk guidelines for its of inhalation tox'icity in small laboratory ainimals are ;;- those set forth in the Federal Hazardous Substances Act (FHSA) and the subsequent regula- ~_____- - tGnnc_ rwaN'rclxd iri the US Federal ResQstcr (1464). These regulations define highly toxic,
Page 584: wrm95d00
50335 3098 Carbon rrionoxide poisoning. Edited by H. Bour and I. McA. Ledingham. Ifmsterdam, New York, Elsevier Pub. Co., 1967. 203 p. illus. 27 cm. 0 S 0 0 0 0 2 53 8 7
Page 585: wrm95d00
Febrtary 1973 IDC MeF-C-203-74 : ® ~ Facperimental Studies on f Tin ' Canned Ora e Juice _ in > (lteoeivaa sapteenb« 26, 1972) 3 To `~ T *t Sato TANALA"n Yoshio IktAa*s -- ru Aiu e1 Al i l ' O , , ra c u/o. , AxAx ~a~u YoA6u and , Tsuyoe}ti FtntuYA*3 (41pept. or ph.ratnacoiagy and'=Dept. of Toudcolo;y. National Institute of Hygienic Soatoes: 1=-1. Kamiyoga 1-chome. Scta=aya-ku Tokyo) . Yanitin= and diarrhoea oaanred in cats tiven a 10 mi per kilo,+ram dose of canned orange ,. •.~ juioasampieoontainin6 high concentration of tin (4S2 ppm), which also dcvdoped intoxications •, in ers, Increase of tin concentration by condensation of the sample resulted in an aoceieration at oatet of toxic manifestations, howeva. adjustment of pH value to nattral range appeared to s.„ . has fittle effect on the development of gastro•intestinai disorders. Presence of tin as complcx wifkoitsate in the sample was suspected and the tin oomplcx prepared from stannic chloride and todim eitraft was given to cats as aqueous solution at various daaes. Administration of the ' oonvp{ex with doses aho.e f ng tin perkilogram developed toxiceffects in "ret)r animal tested. + c Toodc e6ecls ot the jnioe sample disappeared after removal of tin by hydrogen sulfide treatment, but i win the addition of as„much in to the trea^gle
Page 586: wrm95d00
7>. 5. « IJ - If t a zc a..a.~_ YA>< 6ta.1:.eI.ns•1a1.as F., ~ FSC110JIb3YEASbIX B AaP030JIbHbIX £AJIJIOPAX !/ I :y-P (Je- .7-QQ•t--~, d J-71 . 17p44) An azeotropic mixture of 60 per cent tetrafluormonochlorethane (freon 124) and 40 per cent octafluorcyclobui^ane (freon C 316) was studied as a propellent for pesticide cylinders. Judging by the clacticity of the saturated vapours and the chemical (•(i stability, this mixture resum!bes that of freons 11 and 12. The azeotropic mixture of . K freons 124 and C 318 with concenirations used for practical purposes is non-toxic for warm-blooded animals. A slight irritation of the mucous membranes of the eyes may occurs if the concentration is exceeded 20-30 times, i. e. np to 10-15 g/m'. The mixture ) with the concentration of 15 g/ma and over produced a sliLMit narcotic effect. mHpe nFiumeHntor pa3r:ttyHble xMMHxarw s stiAe a3po3oneH. nnrtvuu•rt, PpRr4l,tPrtTatrNONNO-vcTOfi' D'R11 C-J~i~JIEH NE- TOKCiNHOCTH 17POIlEJIJIEH9'OB,
Page 587: wrm95d00
50335 3099 CHEMICAL CO*iPOUNDS--TOXICITYJ LABELLED COMPOUNDS/ ~ LABORATORIES--SAFETY MEASURES/ Dangerous chemical substances and proposals (in 5 languages including English) concerning their labelling , Third edition 0 ,CONSEIL DE L'EUROPE STRASBOURG 1971 ~2% e> R 'Pil~ Y
Page 588: wrm95d00
~ 50335 3101 ~ TF 247 Du SOLVENTS--TRADENAME:S/ SOLVENT6--SAFETY HAZARDS/ 1971 . TRADFXAMES / S~Llf~~JTS __.._......r...... ,_..~. ._..._.. THOMAS H. DURRANS D.Sc.(Lond.), F.RI C. Wth Edition nvised by ER1C H. DAVIES B.Sc. CHAPMAN AND HALL LTD ^ 11 NEW FETTER LANE, LONDON E.C.4. ~
Page 589: wrm95d00
4`~:. 50335 3 103 C INOG°?dS/AMINES, NITAOS / AMINES--CAR c:ANCER--CAUSATION BY CHEMICALS /MIMAi.S__TUMORS / CHEtff CALS--CARCINOGENI CITY / DISEASES=-CAUSES AND THEORIES OF CAUSATION/NITROSAMINES/ AFLATO%INS/ -- Rc 267 in IARC MONOGRAPHS 197J., I r ON THE EVALUATION "OF CARCINOGENIC 'RISK OF CHEMICALS TO MAN VOLU1t1E 1 INTERNATIONAL AGENCY FOR RESEARCH ON CANCER LYON WORLD HEALTH ORGANi7ATlON 1972 -- - -- -
Page 590: wrm95d00
0 500 0025396 II MaC9 (1970) Machl_, ufllard THE 1'HYSZOLCI^IC_r_L ;tQSl'()NwE OI' ANDiALS TO Sc'3Mi S;*-:?:.E p.M TO i:~=:;Zki?l DER7[V7SJ Z"+TES OP THESE C(i?TOUP:DS, by Wf I13rc? iinQu%i:, E. K. Sa:vi:i. eauci watVu ixvuta. Jour. Ind. I3yg. Toxicol. 22, 315-332 (1940) .--~,..- .~ ~__.,.,, ~„~,..,.......... ,..-.,~ -~.,....
Page 591: wrm95d00
... 50335 3102 FOOD--{'l"~.C:~:AGI.dG--'~L~TERIALS / ' LAt?--FOOD FOC3D---co',?TlL*tIwTIO, ,; ?G~. I - -73-1I41-F-S xx MeF_D_d*W-74 Suppicment To The ~ Final Environmental Impact Statement Rule Making On Poiychiorinated Biphenyls u,,s. Food`and Drug Administration Departnient of t-Icalth, Education, and Welfare Sam D Fine Associate Commissioner for Compliance July 2, '1973 .4,..,.., 0 5 0 00 02 5 3 9 1 J- 97o
Page 592: wrm95d00
, t 50335 3100 PYROLYSIS/COMBUSTION - / CHEMICALS--TOXICOLOGY/PLASTICS/ BUILDING MATERIALS/ . 73 III Du ' BULLETIN OF RESEARCH NO. 53. ~' SURVEY OF AVAILABLE INFORMATION ON THE TOXICITY OF THE COD1BUSTION AND THERMAL DECOMPOSITION PRODUCTS OF CERTAIN BUILDING MATERIALS UNDER FIRE CONDITIONS . . By R. E. Dufonr* JULY, 1963 UND E RWRITERS' LABORATORIES,
Page 593: wrm95d00
P 6ES xoU ovS o •a,a 'x.grzaqf~23Ts1 sa'sad IT 1.961 'SCIta1~3.~~dij~ iiY UiJL7 VWYY t1WyXTiil.rsr, a';liiUV ,Ia L0;Tv;irnoA :Duia-,"Ya}alsnPx:l 'd'S i (896T) ~ 6 III le SBtE SEEOS
Page 594: wrm95d00
CHEMICAL COMPOUNDS--TOXICITY/SAFETY GUIDES/ AZARDS T S mu - IN THE :1971 -CHEMICAL LABORATORY editad by G. D. UUIR. BSe,PhD.FRIC Tedu&kd Developnunt Manrger. BDX Qeernicals Ltd. Poole LONDON .THE ROYAL INSTITUTE OF CHEIdISTRY r
Page 595: wrm95d00
?2.II Kr Q 50335 3106 OCCIIPATIONAL DISEASES/ ENVIROI'.~;~~1AL _ .,. _ sf 1= wxxT=.M.XTTMwL,~x .M ~'f~e Correlation of Clinical and 1~;RYiraz~r:iental 1l~~east~re.ner.~s for ~~'Or~:crs Ex~:ose~i to '~i~yl C~~~2cicie -~ --- --- --_ C1 O. 2:RAMER, M.D., and J. E: MUTCHLER'4 The Dow Chrmfaof Comjnny. A!idiand. MicRigan 48610 A mechod is descri6:d for the stetislicat consolidacion and torreietion of `! enriroi ment, I n:ea^_n(menfs and cii.,icrl iindirti;> ir%iuF as eo exa!,iplc a Froup of 1!er.lthv nrrle ..otker% cxlroscd routinek~ to s ins! <:~lorid~ for periuds up to 2S . cars. Rciro%pecli.c in nA1t:rC Iiit' Scnd)' rc.cH(s Secrral !rnlGtllCiI1y slt„'nrrrcant ClfCets frw ut chronic cxpusures to sinyl ch/oridc rud traces of vir:yfi(:ene chloride. U 5 O 0 tl 4 2 5 3 9 5 ~ .
Page 596: wrm95d00
50335 3110 INDUSTRIAL fl4GIENE/TfiRESHiJLD LIMIT VALIJES (TLV' S) / TOXICOLOGY-ACUTE TOXICITIES/ / ; P/ ..z Marshall Sittig NOYES DATA CORPORATION Park Ridge. Naw Jersey. U.SA. 1979 0 S6 0 0 0 2 5 3 99 HA~~DOUS AND TOXIC EFFECTS OF INDUSTRIAL CHEMICALS
Page 597: wrm95d00
50335 3118 ISE--POLLUTION/WASTE DISPO; SAFETY GUIDES/PESTICIDES--SAFETY STANDARDS/ NIOSH H4ALTH & SAFETY GUIDE FOR PESTICIDE FORMULATORS/ U. S. NAJIONAL INSTITUTE FOR OCCUPATIONAL SAFETY & HEALTH, SB 951 Un 197 4C HEW (NIOSH) PUBLICATION NO. 77-100/ HEALTH AND SAFETY GUIDE FOR PESTICIDE FORMULATORS Y. an K Mea S.NMMMI IeYMNe /x Occvwa^+i 9+feq aed hkahh p1.h1pn et T.cheini femca tMCYw1f. Ohio 0221 mry H77 • Mh Uhr Iwt.wNa .t D.cww.m.. D.f. Ow...r.O , pAalft O(fle.. f..hYK..w. D.C. 30402 i
Page 598: wrm95d00
50335 3115 9 (1968~ S.P. ~yth, Heury F., Jr. . . itAhCS-FIIMING TOXICITY DATA, LIST IV, by Henry F. SmyCh, Jr., Charles P. Carpeaeer, and Carroll S. Wail Arch. Ind. HyS. Occupational MeQ. 4, 119-122 (1951) ; 0 -. ~4..•Y..,..r. ~ . _ . .... ..o--..~..w-....~ a5o©0 0 2 5 4 04
Page 599: wrm95d00
50335 3113 I • - . III Me9 (1968) S.P, Smvthz Hearq F., Jr. THE PL1i^E OF TRE TtlYt'sB P'IPtDIA.G TEST IN THE IhDUSTRIAL TGXICOL:.'Gxa IskEvaFJCltiiF by 8.enPy V. Smyth, Jr., and Ctasric3s P. CrarpentPr jour. Iad. ayg. Toxicol. .26, 269-233 (1944) ~~oo~o2 5 4 6 z
Page 600: wrm95d00
50335 3114 Me 9 (1968) ~ ' I %. . euxY I S . P . .A3 i D Aw?CE : I I T ` ' ' -P t O lG 3Y}gIC : I DTA LIBT iII bp M_a,, Mea: y F. Smpth, Jr., Charies P. Carpenter, 3ad Cgrrull S. Wail Jour. Iud. Hpg. Toxicol. 31, 60-62 (194:) t?5o .0n 0 .2 54D3
Page 601: wrm95d00
III Me -76 S.P. 9 50335 3117 AMINES, AROMATIC/BLADDER CANCER/ MUTAGENESIS/TERATOGEftESIS/ CANCER--CAUSATION BY HORMONES/CANCER--CAUSATION BY CHEMICALS/ INHALATION/ / Sc~O~s~~ ~ o~o~ rr* REOUT 1g7~ NATiONAl CENTER FOR i ToXiCol(?CiiCAl RESEARCh JEFFERSOIY,AR{( %NSAS f2079 - .a 0500~0254 06
Page 602: wrm95d00
• samasa;a.E at ~~. ~Ess~.r~s a!~ ~ s s# tl~~ a~r s~rao~i~aa aaiaq~ ~r sl~aads* rr~~s4*"q siatsa p®ss1a: low #q,"a*Ts dstFji4 *~ sasps ~s ~!~, t il;~ tTZB~ !r~r~ ~ msssa3TT ~~3t7~#~. a~ta'tTsw~r'a~i~ s.~T~ea~.nr ~w~aa~ ~3"'t 5~:~~~~ ~ 0167 - IM3d•. a"30izons" vaja Pas Peas > 'S'a :ow d ~1 -1'1tZVI /'wms.sS w!aes!sla0 lw+ss~.~!`i -v1 !Yf 'IaanlF RtT 006 "O!t *,AND/W"r4? 'E: sisl.S pi3 m so[3 jo YOjIt'j--%Orsv .s.li2"3wjrj"u 330I37ll P" .t01tf'[J ,_. :1, . ~ -M'eA4 !9pS • - U ,I uI ` ' lM '~A"ft s°W.Tf sT ssaag "2•ta+r t-86 1 ---~---- . SLBi Ns' •To"?t1t A..i*T;s*t 3e savws% sswaaras3='i *T3T3u&TyS di ~3 9 53~3'~3 1fIiX31 `S'1tHO?1Y
Page 603: wrm95d00
50335 3104 _,. CANCEF.--CAUSATION BY CHEMICALS/l1NPViALS--':LIMORS/ .rnvsnr•r~z..-__rtar~iTr~. /HYDROCARBONS, POLYCYCLIC--CARCINU^ENESIS BYJ 73 II Ib Am76r:--Jsuf': "CAricer 35 -l.,L88-190 (1939) THE RELATIVE POTI:\C4' OF CARCI\TOGEIKIC COmPOL\DS JOFIN TRai.L (Frocr tkr !:e•srerrh lrrtitutr nj t:rr harri! Car:rrr Ilospi:iz! (t}rr.), Londat) It i: evident from the data that have been published in recent ye :rs th:j; there is a wide variation in the carcinogenic potency of the many which have been found to possess this pronerty. In the Present paper an tempt is made to collect the results of experiments on the application :o skin of mice of the carcino-enic compounds used in this laboratory and to ;::- r.-n;e them in order of potency. Most of these results are given in five p: p,r: (i-5) published in the I'rocccdin;s of thc Royal Socicty. Twort ^n;: (6) devised a niethod for comixlrin ; the carcinogenic potency of \';lrlr;as i•.;'. An(I Cli.1. TlieV compared the. nercentare number of tii1:1J:1rS A•iti] :plrticular Iloent in a r^,ivCn nillillier ol weeks wit.'] that obtaiaed standard a-en: in the sai:.e number ot weeks. Tiie mtthr,~; mezsure, oi potencirs ranginti over 3S,00G-iolci, and one may douUt ch ;li~;crencec ire~%~j]~~e a. 0~0 0a 0 2 9 39 3
Page 604: wrm95d00
(1iS6T) 99-T9 ' flT ' Pex TvuoT:tIIdn:a-ap • 8,{g • FuI 'vsJ r ~ € f ~ Tu;Rz7oa •3 or.aqxn pua 'TT~Pi 'S IZos.t:•o ~ e ia3aadas3 ° .d saTs-mo ` • ar `%pSv; • z d.tuait ~ 'A ISI1 s~I~liI ASI~I~S s~tZd~T~t-~'J~I~I ~ (896T? t; 6 9tt£ SfEOS
Page 605: wrm95d00
Z 1v 5z 0 0 0 0 5 0 _ .~.,~...4_ 1Z11A MON Lo::,"a st*1 •0-3 pTotnsg*:i }'[1F?.Z3Gdtti 1Ii:A O46t t ~~n'T: xtz c%1~^ ~ Y ~~g4' `8.'.s3T3tf~S EZIE SEEOS ~
Page 606: wrm95d00
.;, 50335 3119 III Me9-74 S P SOLW23TS--HEAL?'M HAZARI3S/S!'fIr?T GUIUES/.T.NWSTRIAI. TO;ICOLi+~;`.';' criteria for a recor~rnen~° standard . OCCUPATIONAL EXP0SURE- . . r TO TOLWE N E . ~ , G[. S. Public Health Service National Institute for Occupational Safety and Health 1973 .W• I'QSiI%oN (W), C~ e Ir I I . 0 5 0 0 n 0 2 54 0 -8
Page 607: wrm95d00
"AM - _.jir... 50335 3122 A Nodir.a, John H. ed. Animal and clinical pharmacologic techniques in drug evaluation. Sdited by John H. Nodine jandl Peter E. Siegler. Chicago, Year Book Medical Publiahers 119641 xix, 660 p. illus. 25 cm. Running title: Clinical phermacolagy. Includes bibliographies. ,..~....~..: .. ~-.,«,... 0 5~ 0 0 0 2 5 4 1 1
Page 608: wrm95d00
50335 3120 j Ref T 55 Un University of California, Pood Protection end Toxicolcgy Ce ;tEr CHEMIST&Y AKD 1;t3:ECOLOGY Ch AGRIC•LTUW I. CIL:,""+r,ICr1~,S 1968 212 Pages baeie, Csliforau G p~ o o n o~ S4 0 9
Page 609: wrm95d00
. ,t.. ; t`; t{ a: ~~.1:. ltta tt:l.ir{ .r~t ti l~~ttti(is outt:t.t t.~{ tiu put t.!.rlt:cl t>t'{ .i1tO . , ,- . , ~ ..i. ~ cttARt!•U;.!,:©Our).7 ~ t:.::.jt.'.4SltI1tI1!tlU) 1'~P{ .itit) jt) J.)!l~'.t[.'.l((({t; ~~ s;~r.[ o.t<I E::tatsttnu-s~ Ict;tta;oc[ 'a,tua~r~s 1oj ute.t,;.>:ri L ttt [).1;Ninttt slstmvi[tttos t3p% nrn tt!s x t:~ ttut ~lt~tt sur: .C;t~tzv{ a u;nV~ £li:Sl ut!ru.:I.tiuu;, f ':j;i.::r?sl;rd u.r•iV '11J!el CJl•.`• `.C;+rI J•ertrl2 uolNyY ~ry~tu~,7 Il.t.I(I,1r OtvS[1([l `'Q•I IrI `2i ~ L\ a(I2i't' J 'rt `1Lj..t:VS 'd ,12I\3H )~/s•v~h(696~f~s~o~' z «E SE£OS aP"~"" . .%'''`~f1
Page 610: wrm95d00
50335 3111 Ix2: Me g (196g} /~'.ayth, Henry F., 3r. S.P. Fit:.HER EXFFRIEH.^.E i-'ETtl THE R!XGS Y'TFDZYs TU? LN THE Z:30IISTI'.YAL TCl'1.I Cv7,%-Y Ly A Henry F. Smyth, Jr., and Charles P. CaeFRute: Jour. Ind. Syg. Torticol. 30, 63-68 (1M) 0 . . _,.~.., 0 5 Q Q 0 0 2 5 4.0
Page 611: wrm95d00
III Hu2 74 FDA REPORTS , Contract No: FDA-71-310 50335 3125 S.P. Principal investigatcr: DOMINGO M. AVIADO, MD et al Professor of Pharmacology Univ. Pennsylvania `ledical School - , ~wo ~. G4RDIAC' ARRIIYTHMIA IN THE M II. RESPIRATOP.Y A.YD BRO:ICIIOPL2ti0NARY EFFECTS IN THE RAT Ts+st.tess Reports Nos. 1-7: CARDIOPLLMO'3ARY TOXICITY OF PROPELLANTS FOR AEROSOLS. i. ACUTE IA`HALATIOM IN ANESTHETIZED DOGS. Sept, 1971 to 15 Dec, 1971 II. ACUTE INHALATION IN ANESTHETIZED MICE. Dec., 1971 to 15 Mar., 1972 III. LEFT VENTRICLn.AR FIP.JCTIOV AND BLOOD LEVELS IN DOGS. I'tar.1972-June,1972 IV. ACUTE INIIALATIO2I IN AtvESTHETIZF.D MONKEYS. June 1972-Sept, 1972 Y.-l. CARDIOPL'L.`ANARY EFFECTS OF STEADILY IhCREASING CUIiCENTRATIM1TS OF HYDROCARBONS IN RATS. 15 Dec.,1972-15 Dec., 1972 Z. LEFT VEIVTYICULAR FLRNCTION IN DOGS. VI. BLOOD LEVELS AND BRO"IC?IOPULPIO:IARY EFFECTS IN HONI:EYS AND CATS. 15 December, 1972 to 15 March, 1973 VII. BIOLOGIC DISPOSITION OF TRICHLOROFLL'OROMETHANE IN MICE. 15 ltarch, 1973 to 15 June, 1973 , lcasrlss Report No. 10: INFLUENCE OF CARDIOPULMONARY LESIONS. Sept. '73-Dec. '73
Page 612: wrm95d00
50335 3124 IRON /CdPPER/?4OLYBnENt7t/COBALT/?dI('.T:EL/ !JIAANr,ANE SE / 7.INC / CAl)MIL^.~i/ CNROMI TflM/ TODI N?E / SE'LENIhM/ FLT7nRINP: /~'!F.RCIIRY / VANADITs/SILICON/LEAD/ARSFNIC/SMf)Y,INr, AND HEALTH/TOBACCO--S"iOKF--NICKF.L/ TOBACCO---SA'OKINM--IiEALTH EFFECT/ QP 534 Un 1977 f Trace Elements!`in Human and Anhc-&~Nutrition Fonrth Edition ERIC J. UNDERWOOD D.NrOwt of Aniend Seienoe a.d teoeoctioo iadaa:o6AQieWaue QNw~iV of Noeer, Arsmli. N.m.VAb, WOMM AUSu,u. ACADEM[C PRESS New York San Fzaicisw Lostdon 1977 ,. A trbidWry of Hareoert Sraos JoqeoMOk, tu6Hrp.p osor~~~a4-! s~
Page 613: wrm95d00
11~ ,Dwy-7S 5.~. Toxicology, :; (1975) 311-319 Easewcr/Nurth•llulland, Amateri •rm - Prinled in The Netherlands i The acute inhalational toxicity of.trichforofluoromethane (FC 11) is sum- marized in this paper. There is a striking similarity in threshold concentra- tions between the mouse and the rat on one hand and the dog and the monkey on the other. The mouse and rat require lower levels of concentra- tion, i:e. (1 to 2.5%) to influence the respiratory system but higher levels (2.5 to 5.0%) to affect the circulatory system. The respiratory systems of the monkey and the dog have about the same sensitivity as those of the other two species in that the threshold level of FC 11 is 2.5 to 5%. The circulatory systems of the monkey and the dog can be influenced by a concentration of (1 KgC _ _ .. ( FC• 11)~ DOMINGO M. AVIADO !''=SUM111ARY OF THE MOST TOXIC;jTRICIILOROFLUORO\IETHANE 1 05ao d,~2542 , , . Z
Page 614: wrm95d00
50335 3133 III Du2 - 75 s.p. 7uticr,lo~~a (3 9 7 51 a'1 - U ?.... GElsevier/Nurth-flulland, Amsterdam - Printed in The Netherlands i 4it#PROPOSED CLASSI FICA•r1O~y~ L' DOMINGO M. AVIADO 4 SUHiMA RY The 15 propellants are grouped into four classes on the basis of results of investigation reported in this series of publications. Class I low-pressure propellants of high toxicity; Class 2 low-pressure propellants of intermediate toxicity; Class 3 high-pressure propellants of intermediate toxicity; and Class 4 high-pressure propellants'of lotv toxicity. 05000 02 54 22,
Page 615: wrm95d00
50335 3128 I UU;:.O -- a J ~~Isevier orth-Ho4and, Amsterdatn - Printed in The Netherlands Toxicology. 3 197 ~ L NTRICULAR FUNCTION IN THE DOG* DOMINGO M. AVIADO and MIROSLAW A. BELEJ ,pepnrtment of Pharmacology, University of Pennsyluania School of Medicine, Pleiladelphia, Pa. 19174 (U.S.A.) (Iteceived April 24th, 1974) _ (Accepted April 25th, 1974) SUhiMARY The three propellants previously reported to depress myocardial contrac- fility in the primate heart also depress ventricular function in the canine heart-lung preparation. In concentrations of 2.5 and 5% the following cause --denremion: trichlornfluorompthane fFC 111. trir_h1nrntrifh,r,Tr,otF,ano 1F('. QSU~ 0 ©.GS4 1 7
Page 616: wrm95d00
Toxicology, 2 (19741]73-184 - 50335 3126 , seviery or - otlan , Armterdam - Pri..:.r..d in'1'he Nethr.dands _ III Du -74 ~ . ...... . , ., . '- S.P. •~ ~ INFLUENCE OF BRONCHOPULItiONARY LESION ON CARDIO- _ ULh1ONARY TOXICITY IN THE h1OUSF~ , CHARD S.COTT BRODY's,-TETSUYA WATANABE and DOMINGO M:!AVIADO , . .3~Iyepartment of Pharmacorogy;tUniv,irsity o/Penrtayloania ~Sch6o1 ofbfedl`cine~Philadelphia~Pa 19174 (U.S.A.) -~ i S (Received December 8th, 1973) 1 SS PA/17/ 7 t,r The inhalation of the following three propellants was tested in mice: tricl:lo- rofluaromethane (Fluorocarbon 11, FC11), dichlorofluoromethane (Fluoro- carbon 12, FC12) and difluoroethane (Fluorocarbon 152a FC152a). There was a uniformity in nature of response of respiration and bronchopulmonary function, namely: reduction in respiratory-rate, tidal volume and respiratory minute volume, decrease in pulmonary compliance and increase in puI- monary resistance. The differences between the three propellants were that FC11 caused spontaneous cardiac arrhythmias and sensitized the heart, whereas FC12 and FC152a did not. However, inhalation of FC152a caused sensitization of the heart to epinephrine in mice that had experimental bron- -------Rr~-r------._.------T..,~.__._....._...,_ 0 5 t~ 00 02.7 ~'1 ~ 5
Page 617: wrm95d00
IV. CARDIOTOXICITY IN THE MONKEY* _ MIROSLAW A. BELEJ, DAVID GARY SIRITH and DOMINGO M. AVIADO Dspartncentof Phorneaeology, University of Pennsylvania School of Medicine, Ph tTadelpdsia5, Pa. 19 174 (U.S.A. ) (Rectited March 14th,19?4) • (Accepted MarcL IGtb, 1974) The 15 fluorocarbons which can be used to propel aerosols have been trouped into 4 dasses, depending on their potential to elicit cardiac ar- rhythmia and depression of myocardial.contractility. The most toxic propel- lant, trichlorofluoromethane (FC 11) produces both forms of cardiotoxicity when inhaled in concentrations of 2.5--5%. The minimal proarrhythmic con- centration in the monkey is reduced by iv. infusion of epinephrine or by production of myocardial ischemia. The combination of the two effects reduced the minimal proarrhythmic concentration to 0.5%. This pheno- menon suggests that thee hazard of exposure to aerosol propellants is increas- ,,t.~,~se,?~,~„~-..y'~-~„ ' ' _ . . ~ .. • ~ - . I i
Page 618: wrm95d00
50335 3131 @ nae.ialivor'!h ~Ioliand, Amsterdam - Pristed in The Netherlands iIII Dn2-75 _ S.P. ( VIII. RESPIRATION ARD CIRCULATION IN PRIMA'TFS* DOMINGO M. AVIADO and DAVID GARY SMTTH DeAartment oJPharrwocology, University o/PenneyJuRia, 8choel of Medicine, l7uiJadelpkia, Pa. 19174 f1/.S.A.) (Received June 1 Sth, 1974) BUIDQARY I The low-pressure propellants influence predominantly the circulation, whereas the high pressure propellants affect the respiration in anesthetized monkeys. There are four groups according to the level of toxicity: Ctcas 1, bw-pressure propellants of high toxicity that cause tachycardia and hypo- tension; Class 2, low-pressure propeAants of intermediate toxicity that influ- a~ce either circulation or respiration or both; Claas 3, high-pmessure propel- Lnts of intermediate toxicity that cause bronchoconstriction, and CJcn 4, high-8ressure propellants of low toxicity that do not infiuence respiration or wi...u1.Nn.. - -f,..- a_L -1-3 -. .- _._ _ . __ . ..•.- . . 0 s0..0 ~0 2 5 4 2 0
Page 619: wrm95d00
50335 3140 Society for 1aperiictental Biology (Ot. Ilrit.) Symposia. no. 'I, / 0 Cambridge, University Press, 1947- / C v. mos. 2E4 cm. a L Biology-Collected worka (L Biology, Ezperimeutalj QH302.S622 Med 47-23 U. S. Army Medical L[br. ~ [WISO8u88] for Library of Congress - la5Ogfht ~~
Page 620: wrm95d00
NICOTINE--PHARIKCOLOGY/ 78 R~ Amer. Jour. Botany 22, 329-32(1935) 2 DAvTD I. 1IACIIT AX6 It3ARl' E- vAYlS (Reeei.vd for publication July 17,1933) 50335 3137 Nicotine is one of the Ipost important alkaloids known to the pharmacolo- gist. Unlike the majority of alkaloids of vegetable origin, this c.atlpound is very toxic not only for aninials but ,also for living plant protoplasm. In the present paper the effects of ordinary or natural nicotine and several closely related compounds were studied on the growth of roots of Lapintts nlLus seedlings in order to discover, if possible, thc relationship between the chem- ical structure of the compounds and their physiological action. ° COMPOUNDS STUDIED The nicotine molecule-consists of two nuclei, a pyridine ring to which in the beta position is attached a pyrrolidin ring containing a methyl group. In- asmuch as nicotine contains an asymmetric carbon atom, different optical varieties are possible. -A compound known as nornicotine, which is very closely related`to fh"e tieta-nicotine but denrived of the methv1 er,pun in the nvr-
Page 621: wrm95d00
50335 31 29 ~hiser+er 8tortei-Hoitand,~mat~rdan+ - Aint.d in'tl~e 1 e s.RLnd. III Du2-75 jOeAE -IMER'kL?.ANTA H3 THEiil'MIi1i1Y,1RY AM S . P . VI. INFLUENCE OFCARDtAC AN'D PULMONARY VASCULAR L85t[QNS IN'I'EiR 4tA'I"O - ltOgSRT E. DOHERTY aad DOMINGO M. AVIADO Dsparpnent of 1'hown.colqtY. Uniuersity of Pennsyhanio Schoolof M.dieiru, Pb/bdslphiah ftr, 19174 (U.S.A.) (R.oti.ed May 25th, 1974) 8(J1IMARY Three propellants were selected for investigation in rats because of their aoa-uniform effect in mice and monkeys. Trichlorofluoromet.hane (FC 11) provoked arrhythmia in all three animal species, dichlorodifluoromethane (FC 1'2) in monkeys and rats but not in mice, and difluoroethane (FC 152a) only in rats. In rats the alterations in heart rate and electrocardiographic patbern during inhalation of these propellants are largely brought about by release of catecholamines from the adrenal gland, because adrenalectomy or prior injection of beta-adrenergic blocking drugs decreased the incidence of cardiac effects. Rats that have pulmonary vascular thrombosis or cardiac - neerosis become more sensitive to proarrhythmic activity of these propel-' ~ 5 ~ t~ Q 0 2 5 4 18
Page 622: wrm95d00
73 AMMONIA/AIR--POLLUTION--HEALTH EFFECT/INDUSTRIAL TOXICOLOGY/ III TOBACCO--SMOKE--AMMOPlIA/ Re S.P. R. J. Reynolds Tobacco Co., Research and Product Development Departments, Science Information Division. 4WHOWIV lm ;%A COLLECTION OF MATERIAL, T:. 11
Page 623: wrm95d00
• u Ann. ZOL dspu. Staifi (1f77) 13. 343-332 • Lil tosslclt.l III Du -78 debli idrocarburi alifatici alogenati contenenti fluoro S.P. 2 • . Q PAi1'Tr1LEONI (a) e L ZOCCOI.ILLO (b) - . , - . Sumcnary eo~fw- ~~r~. ~ The fluorinated 1>ropellers have a certain cardiotoxicity. They cause disturbances to the intraventricular conduction, to the inotro- pisme and to the arterial pressure. Such disturbances show up in the laboratu- ry rat due to a concentration in the air that once was thought innocuous for this specie. We have analysed doses of 15 % - 30 % - 60 % of CCl_F.- in the air on the tracheotomysed and curarisec'. animals. The vaaotomy protects in part from the occurence of marked alterations ECG, but not from the alterations of the cardiac mechania aln and of the arterial pressure. The arterial pressurc is the cardiucirculatory parameter which remains inhibited lonaer wheq the animal is again breathina air without Freon. After- breatluna air without Freon for ten minutes, rats sul,mittcd to•a'successive dose of ~as are rapidly intoxicated. Lovr doses of CCl_F: in the air (5 %) ma:e rabbits ipersensitive to the«arythmies-producina» effects ~ S o thbadrffali e. x 54 2 5 zp jfnnn 1 ", ..«. . . _ ., ..-.,. .. _.,.- : ....._.....•».a-m tlef averB
Page 624: wrm95d00
50335 3142 Oak Ridge National Laboratory V --- =- U. S. Atomic Energy Commission IN ANIMM:,S `-~ Hartha Gerrard/HZ BIBLIOGRAPHY ORNL-TIP/TIRC-72-76 N A! 10 ~~ RIl •~ i41t TOXICOLOGY INFOR,tiiATION PROGRAM TOXICOLOGY INFORMATION RESPONSE CENTER 9 ea.-~~:~
Page 625: wrm95d00
50335 3109 i 73 ~ ~ F ISOCYICNATES/ CARBONYt FLUORIDE/ 3 5 P -"Jour. of Occupat ona . 306-30? 1973 ) . Human Responses to Isocyanate Exposure WOM & ft% AM I d+a-iai oompowvtk ltwe been 1.- %MY 60M PlwPSw eM " pood b be responMe fa Ior3c Mwy nwtak b uea'atic diamines& jesporvres in wodous sVoaad b tke Since ihe saope d ft pesd"6w deak taaerial atsd is ktnwL''s gesPoeaa sre wMy with isocyanates, a1t 3heu .praetia<ily a;soaialed with the 0espiraoory toaoefticaly wa- iabte thenicsis in qWm, but h.ve iewvlMed dtesim Aa ~~ ~~ their - 1he use of ~ta~x ~~ ~~ muMipiied bR aperknc! #" ndedliiad Pwsence drers ron.1 irand Ttis k aom dft aaeft contre~ 1#re rvot ttue wten inwjia dand taw aaftk a~~ ~ ~ ~ ~W S J& V"= per sk d ei a~ SOCy&,,,a 86 ,olpe MKIWe 'p~ooes: « .pQiication. nkse maler+ats k fecessary br exposure response . cM. Other considerations are incr. voLWity with tempenture risr aapid hydration and dissipation of t in 1lio lrnnidity. R is possi , aA*rme re.sonabty the aposure I of a process using isocyanate pouids on $w basis of votatitit,, satuvation curves. If this estimatic dKaies dwt fumes wip oocur. Prot. ~sures dmuld be instslkd to c de bwW * ng rone of the worke tnoirrd. N tle b~ea ' imne
Page 626: wrm95d00
. . - r-/t ~. . .. '++.,,alebto'Y s c192b1 40 50335 3130 '911sevier/xoeth-Hnlland, Arnstadam - Priotaa ia ''- III Du2 75 S.Y. • VII. INFLUENCE OF PULMONARY EMPHYSEMA AND ANESTHESIA IN THE RAT* . TBTSUYA WATANABE and DOMIN(3O M. AVIADO Deportweewt of Pharmacology. Vniuxnzity of Pennqlwaia SohooJ of btedicine, Phi7odNphia, Az. 19174 (iT-S.A. (Racei.ed May 25th, 1974) $i7lDIARY Ezperimedtal induction of pulmonary emphysema caused an increase in .ensitivity of the rat to toxicity from inhalation of propellants. The emphy- aematous rat showed an exaggerated reduction in pulmonary compliance in response to inhalation of trichlorofluoromethane (FC 11). In emphyse- matous and nonemphysematous rats without anesthesia the inhalation of FC 11 caused tachycardia, arrhythmias and other abnormalities in the elec- trocatdiograta. The tachycardiac response was eliminated by induction of barbiturate anesthesia, which increased the sensitivity of the heart to occur- - rence of abnormalities in the electrocardiogram in response to inhalation of Q50.0 0 0 2 5 4 1 9
Page 627: wrm95d00
Jour-Clin. Pharm. 15 (~ 86-104 (1975) ` MN16O M. Al/iADO, MS. lluladalpbia. Pa. Introdne!!on • recent years there has been a growing -eoncern about the toxicity of aerosol products that are sold for -aeedieie.,l, per- sonal, or household use. The most serious incidents have been death from the in- !>slation of aerosol for household use that is collected in a plastic bag, a dangerons practice which clearly constitutes a mis- me of the }oduct. There is no Questiaat that the fatal outcome of this habit is re- lated to the iWalation of aerosol propel- lants that are known to be toxic to the eardiocaseular and respiratory systems. The potential hazRrds of aerosols con- 'taining bronchodilator drugs are difficult to as.as. The therapeutic value of the drug can readli,v be measured, but the tadeity•®f the propcllants is uncertain. 'TYe srau'}able information indieates that ~.:_!F~,*nisaals the inhalation of high con- to either implicate or exclude the role of propellants in contributing to the fatalities. The aerosol p2sduets intended to humidify and medicate the room are not introduced directly into the respiratory passages. The concentration of the pro- pellant that is inhaled is lower than that of bronehodilators, because of its dilution by mixture with room air. However, one aerosol product for medication of the room was reported to have caused 21 deaths, and it has been withdrawn from the market, presumably because of the toxicity of the propellant. The remaining group of aerosols for personal use, eonsisting of hairsprays, deodorants, and feminine hygiene prod- ucts, peesetst a different form of eazard These are not introduced directly into the air paasapces bat are sprayed on vari-
Page 628: wrm95d00
73 X Re 2 S.P. 50335 3143 daa. OccAIp. Xys. Ya. 13. pp. 303,309 - Persamon Prae 191Z Printed in Grcal Brit.in `- = . ,,... • ..~.~ -. -.. .... _ _ . '," jAGOS ...M -MRCTosicotogy Unit, Ivtedical I'•cscarch Coanc•rl Lahora:oriG, Woodmanstenx Road, Carshalton, Surrey En>;land t ~ . . ~.. ~._ .. INTRODUCTION • • . . . _ -• - - .. . Et•ot.vno\ of 1:nowlcdgc on the chranic e(lccts of occuhutional hazards and of social responsibility coneerning safety standards of exposure created new problems ` 1or toxicotoggical research. Estitnation of Lt)5o %-alucs aftcr dificrcnt routes and periods ; of adrninistration has bcen rcplaccd more and more by scarch for more subtle c!1'ccts. , ....... -,...,~... ,
Page 629: wrm95d00
50335 3147 Newari.. r . }: IR CLkSS ::0. PA*iFHLET t& VIT IM`t, c- Lourl.a, D. B. ; Jose}.cw, M. "f. ; El-n•.cuca', A. A. ('Rew Jersey Co-l.i. `teci. bcnti: try; Dep. Pret*. Med. Co::.^~un. Rea2t)., J., U. se) F~"~--.f3i•M,- THE HZ~_`111T - Ann. In.*.crf: :4ed. 70 (::o. 2) 3Lji-59 (1972) (;.n English) *Keywords:* nickel, cured, constituent; cadtr.iura, ci.red, constituent. *1972, No. 9, W 3258* Ad* Tobacco medicine (che:,is"ry) s 0 sao002s4:46
Page 630: wrm95d00
Cii} .~~:i~: t:~ :~/7T ( t ~ 'L':.~ ~ r~v ~2 ~3 r ;T'CUv,J'F , ,, saat ~ t_.i..• .. y .._._,_.. _ .. v. ti y^ 7./ a3'I v ~ C[Fi~ C i.c-«000 S4lE S£EQS
Page 631: wrm95d00
•7[nnjq :G~ a I t~rt~ ' ll~~ ~a ~:cl e.(j ai)'~~'3~ITY2i~4'~ ~Ybtc+~ ~7S ~ Aan~f%n'4 ~P[I*?/t 3C?.j,i/UkM •(, ""i ,iJ C1[417:1L..1a~.J e111117.bV 3 J ~i11eJll~7 ' airi u'b~~riJS~ THY9l511LlNi3 ;'~t3tiil'~; ~IZ ` SZtm'.~.m72?: ' Si t.~MzQfI'd U:.gE)x-k,T(I u=-gavmxu;ul Z:)uvps ' ti-JUSut3.38dwi 3anposa ;)u,a yas~sa : d ' Pao noavqn vpTcyaAau ° r •g S.~-~.~=„f~aMQ 7PL3 r r -w' --- 11I1£ SfEOS w~v- -114.
Page 632: wrm95d00
ii 4Si-1- 1~ . .. ~.. _ . . . . , ; S.P. UNA". : - ~ TEXflt.BERICHTE J/t07b J 289 50335 3139 XXII HeB -76 Analyse vder Toxizitat Von Pyro(ysegasen der wichtigsten Textilfasern Ober die wichtigsten Ergebnisse be[ der Bestimmung giftl- ger Gase, wetthe sich bei der Pyrolyse verschiedener bedeu- Eander Texti[fasem entwickeln, wird berichtet. Es konnte sin Verglekfi angestellt werden zwischen Wolle, Baumwolle, Vis- koaefaser einerseits und Polyesterfaser, Polyamidfaser 6.6. Auylfaaer, Chtorvinyifaser (Ctevyi T), hitzebestandigen Fasern (Kertpel und Nomex). Modacryifaser andererseits. Die verwen- dete, analytische Vorrichtung erlaubte es, diejenigen Ele- menta, welothe man als Hauptgiftstoffe' bezeichnen kann, wie W. HCI, HCN, sowie den Sauerstoftverbrauch zu berikksichti- pen. Die gewahite, anatytisahe Methods basiert auf der Pyrolyse in Quarzrohren unter Luftstriimung und gieidlzeitigen tR,Matysen. Auf die Entwiddung der giftigen Gase folgt kon- fitw[eriich sine mit festen und spezifischan Wellenlangen vor- genommens Aufnahme der IR-Absorption in Abhangigkeit von der Zea Die Konzentrationen werden durch Datenverarbeitung auf dem Computer von unter den gleidhen Bedingungen er- haitenen Eichkurven ausgehend berechnet. Diese Bedingungen onmbgtichten den Zugang zur Ciasentwidclungskinetik (Zeit vot dem Entwidclungsbeginn. Dauer der Entwicklung, Zeit bis ztu Erteichung der maximaten Konzentration im Gasstrom, tssenpenmAilige0Ent~ddu~g I~ Abfj~ngly(ceft,tion sler 4wq,r! 9 AuBerdem k6nnen die Gesamtmengen der entwidceiten oder verbrauchten Gase mit befriedigender Reproduzierbarkeit er- fafst werden. Die Untersuchung zeigt. daB die synthetischen Textilien, wie Obrigens auoh die Viskosefasem, sin sich von den Naturfasem kaum unterscheidendes Gesamtverhalten auf• weisen. Was das Kohienoxyd anbetrifft. so ist die maxima:e, zwischen 51)0 und 600° C stattfindende Gasentwicklung bei Poiyamid- und Poly'sterfaserri, Wolle, Baumwolle und Viskose• fasern identisch, bei Nomex grbBer und bei Acryl- und Mod• aCrylfasem, Clevyl und Kermel geringer. Die hiichste Kinetib wird be[ den Cellulosefasern festgesteltt. Hinsichtlich der Blau sbure ist bei verh8ltnismi9ig niedrigen Temperaturen (400 bi; 5000 C) die Entwiddungsgesahwindigkeit hoher bei Acrytfaserr und dann der Reihe nach bei Potyamidfasem, Wolle und hitze bestilndiQen Fasern. iJbersfeigt die Pyroiysetemperat.ur jedoct 500° C, so sind die HCN-Erzeugungsgeschwindigkeiten hod und annihemd gleioh. Nur die hitzebestandigen Fasern weisef sine geringere HCN-Entwidclungsgeschwindigkeit auf. Bein Sauerstoftverbrauch entfAllt die gro0te Menge auf die hitze bestandigen Fasern (700-800° C) und dann der Reihe nad suf PA, PES. Woite, Viskose und BaumwoUe (500--•600° C). r361 ~
Page 633: wrm95d00
I B . 50335 3149 III Me9-76 S,p, Jour. Water Poll. Control Fed. 33,366-370(1961) Ingols, Robert S.; and Fetner, Robert H. _. :+iF~' The study of toxicity of chromium compounds has been a niatter of inter- cst for many years, yet experiments have yielded a widely divergent set of conclusions concerning the mz~nitude of the toxicity. Studies by McKenzie af al. (1) with mice have indicated that no apparent lesions develop from in- gesting chromates in the drinking water over many months. In a study of the BOD of sewage by manonietric tech- niques, it has becn shown by In~ols __ and Kirkpatrick (2) in long-term res- proaches to the problem of toxicity, an attempt has been made to gain an understancIing of the mechanism of the toxicity of the chromates which should aid in determining permissible concen- trations in industrial n astes and pota- ble water supplies. Test Work Dnrinn di;estlon experiments (4), it ' n-as noted that mold mycclia appeared on the surface of those dioestine mix- tures which were unable to reduce all Q S O O Q 0 2 5 4 3119
Page 634: wrm95d00
,, _. ,7 f !v S.m S. ir. wi.-- Amurl nd~.,4•:.- U~ r.~.~•a.~.r .. • 1J tr4~r /rr nwulcr . . . . . . . • . • . n si 7s C...rr. Itl.-- SuppicaYW. /., i!:: b~rl,~rrr: .: r iscu:J G.Mr Iinr; IJ tintf; ttKra• er: nK'ILNkvI ln 1!It' n1•n••_• ...•, npur u, I~rt mdt :•1., r It I`er. i:a.ed .. (•:n.nrlc. $pcci:r! rata~ •.. .:,Inat:, 1:, :dI .~c N HU nN{1Kt+n}:Ihc Rr.7:n:• 4rr a;u.n.d in Ihr nl'\1'ItU puPt:ab.,n., Khie$ n ot4ain.,1•`.' :• ~a nt aAr[c tram Ile liaed ro rLd tey-t" c.w.'r or Jirr•-I'a trn:n t6.• \\ orld I loaith lhrcmitation. I li.nihuli.ar 7J 0 F TI11: tt'Ofiln HFACTtI OICC:AN17ATIOK vv~' .,ul Saki• c •nrt.r. A aempl.•rr n of t',: Rulierin fr,lo Nu,.ian is atuil•.hic. / 1)E L•ORG1N:S:171t)\ NIC)\f)IALF t)G LA SAATf v~ ~J ,~r1EKA'ATIOtiAL ~O?~rERENCE ON ALTERK,-1~'E~ Sf.CT1CID .• FOR 6 CTOR CONTROL iS 19 Fchru:ry !971 Attlnta, Ga., USA 15-19 :bvrier 1971 f'ir l4 ..t.~.. e s c . ~f .. _ iasr. IV ~.~.vs aC•1ar - -- 1'°•. S~$<g s ~ ~Jr ~!.S «. . "?K• 's?0 / `r~mt'~sL,~.J~i~tfln4c+a~,,t . . rv,• 1:-1 A IG.i~ Y ~j ~ ' tFF rr1~?rnrtw:!° (?rY?[ .~ U. t~' ~ t / I r'Es/rOsft`~cb F' ^ r ~f y (1R(„1NIi.r+) IIf1N O~/r i`'•$~~+~Wt ,ll.lli,ll.lli Oi Tfll~ lii / ••-r~. •, n( r6r d',c:./ ..... r.r ~ ~JLP~JI Jf~ I~~ RIILLE:TIN DE L'ORGA\I1,A"tlO\ T\1ON1)fALE 1)L LA SANrf: lkax vt,lunus dh Ruli, ti. .fr• fPr,e.nriunimr nrnndi.rlr Ae la •Gtrui paraiisrnl dwryui ; ru,n; chaque tolun-a ea put•!ii. J'ruJnuur. en tia nunKrrcti Atnna•nd aemrl rl ` n.,,rn.,) .•. irs 90; - t'1 llo,tkl l.c numlra . . . . . . . . . . . . . . . fv.a. IU,- LI 13.?) Dcs sutq+l:•ment> an Ru1MUn. eompris dani I•alwnnrnrenr •innuet, sont tKtNiea.k• I:ntp• a arnrc. I:• p.uvcnl an-,i ctrc a.hctn x:pad•m.:nt. Ues pris sp.i'i:,ut Pnur 1'sbonnrmcnt d I'enscrnbk Jc, pe!•i,.ation, de I'Oh1S ou d ccr..nrt J'enuc ci!es n,:np;rn:mt Ia B:dkrio ticurcM dan> Ic r•.talt+ruc poMicauom dc IY)\tJ. qui peut i•ua ubtcnu ~ratuiternent aup!i• <.kp~~~lyjj(((r: tirr> mcnti.r u.'•c urr Ic; Jernirre,Sa,4pu c r!e Ia t.narrtur:. ~ ro~urk Sert•ife rjC Uislu6r<. rt U~ `~a•nlC'Uc'nrI Sui+,t• l1ne d:ulu:•G- i:::}raL en ruue r)u RrJlr:in c+t crrkn:crn piil.lil~. 5 4 COi\a`RC.1CF INTERNATIONALE SUR LES INSECTICfD!?S DE RFtt!PLACEMENT I'OUR LA LUTTE ANTIYECTORIELLE 1 r N r ~ t,t'1 ~ n1 ~ if1 IZCCP!': ClI by R. j r=:• 0 I.S i::^USieO ~.,~{ / . ~ C21a '~Lti ~ ... ~ FilTN Q C'ANI71Tl1N
Page 635: wrm95d00
50335 3135 ' I i DuL-7S :11.1P 'St o IYA~( P4,-d D Jlr. Aviutlu Iuts tlone us u l;rvait xcrvice l,.y 11uUiti, lu;;ctltcr ucoutldirati•1l lilcratin•c ill his 4•uuttnrlteusivc revicw, "'1'uxivity of A ero;ols. "r 1would like to cornment on his nrtnlysis off the increase in death-rntc, atnong astliuuttic children nnd young ndnlts which necnrred in certain countrics (luring, the drv:ulc of tlie 1960s. TThere «•ere cert:tin coutt- trics, ineludi:no the United States and Cnnnrla, that sold l:uge amouutx of nstlnun neLnlirers but were spared tl+is incrcase in tlcs<ttr rates that was so mnrkcd ill l:n_lund, Scotlnnd, and oth:er countries. lly elsidetuio- 1o-icnl investigution of these intcruational dill'crcnccs Snnpests that the satle and utie of the high-dosage ibrnts of isohrotcrenol (five times stronger tltau any rnnrketecl Lere Or.or~lat~ ~st~ ~t~ tl~ int~na5na~•ar~ tiotts. 1)iffcrenecs in prottcllant; coultl not t t.ltink it irould be uxrful for tlic elli- 4lt•iuiulugitits 111111 l1harmncolo"istti 141 work wurc rluscdy ill the rantitmitt" ntwly5is of this inc:rcu,e ill drttli-rnteti. )loteeti•er, ttnfi) these internntiounl variations are cxpInincd with u more fentiible alternntive hylrotl:csis, I still think the weight of the dntn point to tlte toxic.ity of the active in-P•eelicnt (iso- protercnol) as the important factor in these clcuths rather tltntt the Trrrol>ellauils. References 1. Aviado, D. M.: Toxicity of aerosols. J. Clin. I'hnrm. 15:$6 (1975). 2. Stolky, P. 1).: Astlama mortality: Why the liniled States was spared an clUcmic of deaths due to nathma. Amer. L'tu. T.esp. Jlis. 106:R8:S (1972). ~ Edilorinl: Asthtaa dcaths: A guestion ntactsered. Jtrit. Mcd. J. NovetnlNrr Z5), 1R72.
Page 636: wrm95d00
~- Ycj TT •~~_ ~ ~:.,1 ~i y + ; ~ ..,. ,,. . ... ~. . .,. t ~. ~ ~ .. . .. ... ', _. + . _ _.. . . . .. . . : - - LStE SE£OS
Page 637: wrm95d00
--.+- -4..- .2 • • t • . . ... . . . . .. •sp.(qajnutusv; au}unqanc puz awumxu 2ucro sluacuuxtxa s.w [}o,iM iaqun; lu}uanns pej sv'+LL 'UM LUW; Pa+cWp spunahuo~ wpGioMN xuow 4m cun )a szsajw.(d xp u! pnsai4g s, pag -Vnur.b MP pa"3!pcu sccxp g.noWH a psuatu sluxuuacLx,.; -'WWH 'S JMNK[,Cc1 utqsdcueH +.aH ,}o AWssrun,1 I IT os patuuKIns se.x ..=u:13u s!"Pad xLL.. PDt;c;w scsayP sVfit '31.'lj X %bl +mw Alemorm r "d'S $tZa~tXI 4 a 4 *11€ sECas
Page 638: wrm95d00
R 50335 3152 , -~7Tw 4~47s') S,P. L. W. H,IZLh'TON, T. W. TUSING, B. It. ZEITLIX, It. T1[iFSSEN, Js. AND H. K. D3HRRR- Jlssleton Laborate.rics, Filts C&urek, Virginia, owd Central Lsboratorier, General Foods Corporation, Hoboken, New Jtrmy Iteeeired for puldica6ion June 16, 1856 / H C HC ~ C-CH=CH Counarun, 'XF IX (1955), 1,2-beaaopyrone, (' I I HC C-O- CaU, N C/ 0 s©o0 0 2 5 4 4 1
Page 639: wrm95d00
50335 3160 RJR CLASS NO. PAMPHLET XX MeF (1972) S.P. R. J. Revnolds Tobacco Co., Research and Product Development Departments, Science inforr;atloa Division ADDITIy'x:S, ..tiC~RLfSIENTS, INC:.UDING UNDESIRABLE CONSTITUENTS I1ND OTHER. D. 372, T0`CICI?`"' 15F FOOD ADDITIVES, by R. J. Reynolds Tobacco Co., Research and Frodt:ct Developzent Departments, Science Information Division, and LeRoy Neeic. 1972 A collection of material Winston-Salem, N. C. Q ~ ~1 0 'q 1 0 "_ S 4 , 6 9
Page 640: wrm95d00
50335 3146 F ~ xx MeF (1970) S.P. ? 8. J. Reynolds Tobacco Co., Research and ~ Product De,rslopmea.t Depsrtmeuta, Science. Inforcnetion Division 4 SPiCIAL FOOD TYPES. B 130. FOODS j CE324Tl.TNiNG GELATIN OR GELATIN StTB.STITtIT'dS, ~ ~Sf A._ 1: YlAV»n7rla ~~ti`°^^r? c.^ O-........~. -~ _I_ .~ ~ ..•, .....iw6.aa WY ~ Proauct Develo;ment Depeertments, Science ~ Information Division, and LeRoy Meek. ~ ,~70 Ac~I3sction of Haterial ~ nston-Saless, N. . .~ 0- 050000 1 Z 5 4 3 5 i
Page 641: wrm95d00
50335 3148 : I I7 ACc in oct icn of ! Me9 lnf orn:ation ;(1968) ~ S. P.`=• J. fieyin^RdQ Tabacco Company, Rasearch and ± f::oduct Dc^7eZoumr~t Departments, Scieacn ~ Infoz~.tion I~i~ai3son ~ iilMCITY Or CYOMUGAL MiFQUINT?S -- A Ccx iection of ZnFO;mation, by R. J. Itey-nclds Tobacco Cottpany, Pesesrch r.rd Ptodvct Development Departments, Science Io.foraation Divf.sion, and William W. Menz 1968 Winston-Salem, N.C. ,_,- . -~----- sQ~~ osvoo0 2
Page 642: wrm95d00
. 50335 3151 POLWINYL CHLORII)E/PLASTICS--TORICOLOGY/ lSlOl.tulillAl'NIC DATA ~ ~~~,•"rr ::~• SH£E T n)n I- t~ 13 a,P• tirr.rr .?arr rrI $@',~ ;~~r1-r« Srpten bc•i•. V~~ 7. Auzhor(s) 1 `)7;i ~ J. E. I1liripol, P.J. Garvin, I.J. Stern, R.F. Wallin 9 F'cr(urmn u:d~nrzacrun \amr and AdJress raveno'1 Laboratories, Inc. /y,• 630i L' In Avenu e !lorton Grove, Illinois 60053 ' ~ fira Absrraccs Vlethod of s01Ubi1ization,-3osage orm and route of aCI1 which are critical in the distribution and excretion of di-(2-ethyl1: one of the most widely used Qomponents employed in the forirulat chloride (PVC). Changes in the apparent volume of distribution c aqueous suspensions were used for injection of the plasticizer inr: in the systemic disposition and distribution of DEIiP were depenr; of the dosage form. Valid studies of the biological effects of parf DEf7:' ^^::st';c pcrformcd ~•ith a dosage form of the plasticizer 1:. pf~•p.2544Q
Page 643: wrm95d00
50335 3158 I xx MeF (1970) S.P. R. .,T. Reynolda Tobacco Co., Research and Product DevaloPment Departr,yents, Scicnce Information Division ADDITIVES, Z`•YGitEiII:?9TS, Ih'CLL3DIl3C il 4f~9 ~ tfld11RC'«A i-EZtT (`f1_3S1'1rTi iZ?PPC AtJi1 n'T'T.Myw. SY~~t~TIG FLt:QUP.hH1J, F'U.:'li1 Slil~L'ti: . L~, E1C., by R. J. reSLoId9 ?'c5acco Co., R_resrch and Product Developaent Dcgartments, Science Info:-E-.atioa Divis:on, -nd :,cnoy 1970 A collection of satericl Winrton-Salem, N. C. 0 S 0 0 0 0 2 5 4 4 7 V
Page 644: wrm95d00
Archives des Maladies Projcssionnellcs, de 1{ifdecine du Travail • tl de SfcurilE Sociale (1'aris), 1973, T. 34, no 3, hiars (pp. 117-125); H. DESOILLE, L. TRUFFERT, C1. GIRARD-WALLON, J. RIPAULT et M. PHILBERT . du dichlorotetrafluorocthane P echerch& experimentale de la toxicitc chronique 6ventucfle The exposure to atmosphere•s containing I p. 100 (in volume) of dichlorollfra- fluoroelhane, luv hours a day, (ive days a week, during cighl months in the rat and nine months in the rabbit, has induced no sign of intoxication in lhese animals. Considering the individual variations, r,(len important, oj the 'amounl of red and while blood cells observed'in lhe ral, no significant variation has been obscrred in this animal during the length of the exlxrimentaliun. a~ 0 0 0 02 5 4 44 i
Page 645: wrm95d00
r » 50335 3156 FLAVORANTS--TOXICITY/ VIII Ne4-74 OR?zL-TIRC-73-8 S•P• *'"f' Helga B. Gerstner May 1973 ~' TOXICOLOGY INFORMATION RESPONSE CENTER Work supported by the Toxicology Information Program, National Lry.~of Medicine, National Inst t tes D t f epar , ment o . Health, Education, and Wel ~ e NLM Interagency Agreement No. OAK RIDGE NATIONAL LABORATORY Oak Ridge, Tennessee 37830 operated by UNION CARBIDE CORPORATION for the U. S. ATOMIC ENERGY COIu1ISSI0N , ., ~ -.,,,.,..._-.- .. . . ~ '05000O'2S44S of Healt o%1,' ~ are 40-274-71 395 • ,u1dY C _______-.--~-~------~-.
Page 646: wrm95d00
50335 3153 ~ I I I 1~EI~I'fY-~SF ~B~Ei~BgDv~IFi.i~fl~E) :'~E~'HAi~ : A NE1d ~Du2 1(1970) S8ycxs, R. R. TQ N? CITY OF' DIG'IZA .dI-DIFLVLP-O li:t3s'itM: A NE:~ &~_"IC~ra?~Fs by R. R. 3p~toxs, W. P. YQr.t, J4hnns Chex'ny o.;c s:--u H. f3. 5i3;<ai Bur. Miues, Rompt. Invest. 3013 (1930) .~...-„~,<:.. r":~ . 0 5~ ti t1 02 5 4 4 2
Page 647: wrm95d00
V I 50335 3167 n - V71"m - Ail (77 • n At t ., ~.~ 7 (' t:.~•LP x s~< ( ;n
Page 648: wrm95d00
50335 31b8 V J~-- 1.~:~. V~. ~ _.1.. olt..:a .2`...ap+.,. a... ... ~./• ?. [,?~ ....;1.11i ~_ t.~l;:.. ..._.•. .~.~..: ~ ~ ~ ., jc ':^ na ~ i-10 ~ ~ "S 4S7
Page 649: wrm95d00
50335 31 61 I Toxkity of Food Additives and Contaminants XX MeC5-79 S.P. It needs no saying that food is sel- dom sold on the basis of its nutritive value alone. For the consumer accep- tance, a food has to be sold as a product with flavour, colour and texture cha- racteristics that appeal to consumer and bhould be of an advantage to him. For this appearance, a number of food additives are used. For this, the Pradeep Aggarwal, Department of Ph.armccology, Post Graduate Institute o{ Medical Education and Research, Chandigarh - 160 012. not detoxified, they will lead to delete- rious results. A number of vegetables especially Brassica Family and Soya Beans contain Nitrogen. Food stuffs like Crambe seed meal contain Goitroge- nous substances which have to be de- toxifed before they are used, by treat- ment w ith gaseous ammonia. In gestating rats, caffeine has been amounts and conditions, reasonably re- reported to cause foetal resorption and lated to tneir use. should be tal:e n_into__._.ofhez.._ _,:.bnarmaliti.-s=0 0 5 0 0 002S450
Page 650: wrm95d00
50 335 31 65 CHE~IISTRY, ANALYTIC--METALS/TERATO~ TERI~IARY TOXICOLOGY/ COPPER/MOLYBDENUM/MERCURY/CADMIUM/ /METALS--TOXICOLOGY/LEAD--TOXICITY/SELENIUM--T(1XICITY/ HAZARDOUS AND ~OXIC SUBSTANCES, A SERIES OF REFERENCE BOOKS & TEl~XBOOKS / ~ Series editor: Seymour S. Bjock RA ~ CITY OF- 1231 OeA ~ i ALC'7~\0 i METALS 1978 + }~ IN THE ENVIRONl~E1~T~~ IN TWO PARTS Part 1 varlt 21 I EDITED BY Frederick W. Oehme Comparatiue Toxicology Laboratory Kansas State Uniuersity Manhattan, Kansas MARCEL DEKKER, INC. New York and Base! 0 soo0o2S4S4
Page 651: wrm95d00
50335 3169 4 ell Bzrrning E:ha1 NOXICZTY OF ZtiDUBTRI?3. ORCAPZC SCL r1~. TS 1953 4•'•3. PaAes Cberf.ss7. Yublishing Co. Naw Tcorlc
Page 652: wrm95d00
50335 3162 ~_--- iL1LiOGRAPlSSC DATA 1. . lccport No 2. 3. Rr.cipicnt's Accession No. FET N9'IS PS'7J 581 rit(c ard subtitle 5. Rerort Uatc T.Dxicity of Gaseous Halou rbons Ma 1975 ~ (A Bihl:ography wit 11~T~racts) 6. uthor(s)- B. Pcrforming Organization Rept. Pernell W. Crockett No. 'etforrnie:g Organization Namc and Address 10. Projeet/7ask/it'ork Unit No. ! tjonal Technical Information Service 5285 Port Royal Road ~aP•°^~•^1 °1 id-9fi•td. YA. 22151 11. Conttact/Gtant No. Springfield, Virginia 22161 SFonsoring O:ganization Narne and Address 13. Type of Report & Period Covered Same 1964 - Anril_ 1975 ......... ;..~: ~..~~~ ,. r
Page 653: wrm95d00
r 50335 3164 r A Eiblio,ra,nhi with Abst;acs Searcti period ecvered ~~•LClti.'r't•: i564 - i-iay 1975 ,hC1-nnl1 :r ( rr; . .tf y l. - C!L`!{. flvl~lil,a~ 1JetioLnai TechniL . ~: Tc n ct: i nfci ,~tien Service i ~'' F-?; ~n` mation w~cc 528., r ort f:cyal ;~.,c; ~:`~ OF rC'. t.1F;Cc Springfield, 2Lio? Sprir.yficlu, Vil,inia 22161 12. Sponsotict (;:pe:+z:;ien ;.:me acu h~,;+tss 15. Scpptemeotary :ictes SU~Ct Se.~~s \~' S '~ ~ ' 1 ~ • s o c 9 Nat;cnal Tec_,I In!cr^1 ati~n ! ?/I'S-: ; 3u~ U. CO:.~-73-11~;,1 14 TIS! S 70/0432.-~ Scr lt. Ae,:t,cfs ~._ ~._~.. Slil)jC',CC ll C2s if Cll c LO};ICOiC+_1C l u;3;e- aie_c:;nted h,+_.; c~• rnon SeS used as fire er*irn,uistier:, u,-t1:"ics, solvents, pesticic":-s, „n:i !ero-soi pro- pc11a,.IS. ( 11)1S U'r C 1Ci i~)Iia:G'1,'t „ Cv ;C~ 1::5 SS c'~l)jtra CCS, 18 OI ;'iliCi) are 11.'. entries to the previous alitio:,. ; ..- G -) 0 0 ri 0 0
Page 654: wrm95d00
50335 3166 i ~ ~96s LPt,L lqr?6) VT Re -77 7WID7CfCiTY OF THE HIGHER O3d;1" OF NI7RO£EN S.P,9 , . R. GREENBAUM Frenchay Hospital, Bristol, England Q 0...,...Od_ Serious contamination of anaesthetic nitrous oxide by nitric oxide and nitrogen dioxide occurred in England in 1966, and drew our attention to the problems of production and purification of nitrous oxide, and to the toxicology of these impurities. Nitrous oxide is commercially produced by hcating pure ammonium nitrate to a tem- perature of 245-270°, and allowing it to dissociate exothermically. NH4NOs-+ NtO -1- 2 H:O + 10.6 Kcals The breakdown of ammonium nitrate to produce nitrous oxide and water is a gross srimplification of the true complex chemical reactions in the highly ionised liquid melt of decomposing ammonium nitrate (Austin, 1967). The detailed reactions are not iully understood, but the final products are ammonia and nitric acid, nitrogen and nitric oxide, and nitrogen dioxide and oxygen. The reactions may be summarised by the following equations: 1 , A NH4NO, -. NHs + HNOs , 2NH4NO3 -+Ne+2NO+4H:O 4NH4NOe- 3N:+ 2NOz+8H:O 2NH4NOo-•2N:+Oe+4HxO ------ . },iut.lv rPaCtivr lFie. 11 wl:.-n...... A:-:a_ 0~ t) 0 n 0 z 54 55 0
Page 655: wrm95d00
50335 3174 HeF (1970) S.P. TOXICITY OF METALS IN FOOD. R. J. Reynolds Tobacco Co., Research and Product Development Departments, Science Information Division ADDITIVES, INGREDIENTS, INCLUDING UNDERSIRABLE CONSTITUINTS AND OTHER. D 370. COATTAMINANT8 & OTHER UNDESIRABLE COMPONENTS, by R. J. Reynolds Tobacco Co., Research and Product Development Departments, Science Information Division, and LeRoy Meek. 1970 - A collection of material Winston-Salem, N.C. --, r' 1 -a.~----~.-.- ~:.~.. 0
Page 656: wrm95d00
50335 3177 III 1nv?CI1: C^ XS%1r MeA 'C~tiATES, fi LTI'L'P.,r'TUpL T 7 SF ~At~r;, (1969) S.P ', jP ;.: Yr ..~,- ,.,- - . . . .~ ~ .. , .~ x. _ ..-.. .. ~ ..Ja i i ~ 54 6
Page 657: wrm95d00
ia 1 Toxicit3spof Gaseous Halocarbons. • A Bibliography With Abstracts. ~sr.~~oc D.~(,'~c ""M 50335 31 63 bor(s ) Mn.y 6. 8. Performing Ocgnnization Rept. F,rh,mrri .T_ T:Phmann 1 No. - formin., O:aanization Name and Address 10. Projcct/Tnsk/Work Unit No. ~aticnal Technical Information Service 13. Type of Rep~rt & Yeriod ~ 5285 Port Royal Road / U S Da?oNmenf or Cc merta Covored Springfield, Virginia 22151 ''"°sP"^or;.,d vA 2s», f ) '1v 1 ~onsorin~~e NTISearch bibiiogz~aphy contains 57 selected abstracts of research reports retrieved using the NTIS on-line search system--N`ilSearch. Tox-icology studies are included which cover all types of halogenated hydrocarbon gases such as those used as fire extinguishents, anesthetics, solvents, and aerosol propellants. i upplementazy Notes Q~ ~ Cl n t) ~F3 4 S 2
Page 658: wrm95d00
i XXII MeB9-76 S.P. HEALTH HAZARD EVALUATION/ Richdel Corporation, Carson City, Nevada Author: Melvin T. Okawa ___. . . . a a•.la-a,i. ..a.. ...t w a•.. .. ..a.. • /`•E'a t'.:c..: //- ..-.t:.rt:a.n \A :•. •:1 3.1•}:a•,• IY •::tioneI li:st;tute for - Occupatit:nal Safety and Nealth Itaz,;rd Eralc:aiion S:'rvic.es Grancl,, Div. of Tech. Services 11. cVnta.,eLtic....nt .,.. 50:~ U. S. t`ctst Office I;c,ildinl Cincinn: ti , Oliio ;I5[0?. u. ~ : 13. 1Y1..• ad K,•po:t & 1'ctud i:ational }ns::itutc for Occupational Safety and ifealth c°`r"'l s P,ir;:l4r:u [:;;ilding • Final. Auq. 1974 5600 fisnr'rs Lane ~<. l:oct;ville, ;-:,ry iand 20852 .f f l r., dinq o Oeternir.atien: A plant involved in injection lro 2 s. Krl.W, u~t, exrosures to vinyl chloride and trichloreethylene, which is ~ used as a d^nreaser. It was deterr.~ined that a potential health february 197~ hbz~lyd froat exDGSUt"e to vinyi ehlori(:e did exist in the Rer.rind a. lL•,i.r u.ntr Room, and a potential hazard rt.ay also exist in the injection 7A-9G-173 salding areas.. Trichloroeth.vlene was .judned to be not toxic at the concentrations r•.easured at the detlreasing operation. ~~ lh-~z4rdo~.ls ra~c:r•ials,ials, Toxieity,' Toricolv;y, Criteria, IrsFection, Stcnd4rrls, I;ecos~a~n- dt+tions, Ir::ustrial vinyl chloride, polyvinyl chloride, injection molding, deQreasino, ehlorohydrocarhons lhal>~ hJt~r0e~uaic•r0 T~:ict;• 4ef4l:~i~:tion, Occupational Safety and tlcui Lii P.et f 1 ~+C3 14 II._J 4 : polyvinyl chloride was studied by t:ICSH to evaluate erployee FB 0 9~0, trichloroethylene, vinyl plastics -
Page 659: wrm95d00
6 TECHNICAL REPOFft DATA (Please read Instructions on nce rcverse bejore completing) 1. REPORT NO. 2. ~ FPA-600/2-80-057 II Me -80 S.P.S I 7'flXICITY OF LEACHATES 7. 11tfTftOR(S) J. l.. Epler, F. W. Larimer, et al. 9.PEii:FORMING ORGANIZATION NAME AND ADDRESS Oak Ridge National Laboratory Oak Ridge, Tennessee 37830 1Z9PONSORING AGENCY NAME AND ADDRESS i+fmicipal Environmental Research Laboratory--Cin.,OH Office of Research and Development U_S. Environmental Protection Agency Cjncinnati, Ohio 45268 156 SL}PPLEMENTARY NOTES v Project Officer- Donald Sanning 513/684-7811 50335 3172 3. RECIPIENT'S ACCESSION NO. 5. REPORT DATE March 1980 (Issuina-Date) 6. PERFORMING ORGANiZAT1ON CODE I 8. PERFORMING ORGANIZATION REPORT NO. I 10. PROGRAM ELEMENT NO. C73D1 C 11. CONTRACT/GRANT NO. DOE-IAG-40-646-77 CQA-IAG-78-DX-0372 13. TYPE OF REPORT AND PERIOD COVERED Task Final 14. SPONSORING AGENCY CODE EPA/600/14 1 ti.IE6STRACT i nThi~s r~qpo r~epr~err's Sm~tiAi s4i pl i nary effort to establ i sh a data base '~or"~vaYua ion of the taxicity of extracts from solid wastes representative of varinlsc _- ~ - - ---
Page 660: wrm95d00
1 50335 3173 j,o 3 3p- 3f3 (lyrfi) _ 'rom the Department of Pharmacology, Sarolinska Institutet, 8toctholm, Eweda-L j i 73 X Rel-81 S.F. o S Q a t1 fl The Tozfcity of Low-moiecular Tilloi-eerides. k LRVM WREn.~~. Reoeird ao ep-B M. Intravenously administered emulsions of tributyrin have a marked effect in respiration and blood pressure and a surprisinglF high tozicitf (WnET1.n.-D 1957). On tbe basis of these obserrations, the toacitS of other low-molecular triglycerides has been in- vestigated. The LD,, of intravenous emulsions of triglycerides with fatty acids containing from 2 to 11 carbon atoms was de- terniined in.groups of mice. 2 .. Experimental. 431 the ]ccerides used were produced syntheticaIl~ br esterifi- tiA of &y~ and the relevant fatty acidg in the presence of Z`a rr- LL's reagent (na]rh-thalinsnl»F ostea*~ acid'; aocordinE to the methoc r~.r .as:~ ~-?i .r~.r.as: (IJfGl1t. i i7~nnor,. ~ .
Page 661: wrm95d00
n14y j-Z~ 3t1 ~ ~- ~~7.T ~ ~~%Jx ?Lif3T^ '1 , 2~0.0 9t:tii } r c tG L - rt -~ [OO t T, 7i-, y' BT . ~TTjr l~IiTj f....j QL1E SFEDS
Page 662: wrm95d00
------- i..__ 50335 3179 TOXICITi OF NOy VAPORS AT NERX Lt?N LEt'IE 'LS ~ 7 r. T 1... i~.E:..hi C;1 1."T T'.Ts)7 t:... ,_Y2G! 1 n 0° ~ /~ G ~.~ 3, 2 9 441 8
Page 663: wrm95d00
4 TOXICITt DES HYDROCARBURES FLUORfS III Db2-80 s.p. AGENTS PULSEURS POUR AAROSOLS i" B. Bm J. DttfAux et F. PRomoRm . suMMARY Alom of tie Jirorocarbrins xnd as proprJlants in Ae aerosals ire toxlr. Stadies coAdircred on di,(jerrat Qaiam! ~ ~~ e tke t~'eru orineijpnlly at du ,I+wn bk iwew fq#.Nwa NvArcts, ue ixay dou+tfp t/ie j^twe ll, s**t,pnod +wf Prope&ket. _ Ti fbd dtrset amfelty, aoW be .W' d a Jowg-urm dm++r d'dwkdm ojrt+ie ssmasp 6erie oz.we leyer. hJaN +sl'iiw row6lle Anund, tie oxtAers adasawte tbe oaW /Amm Sa of Awe praiarw and dsk re/Loc«wear b aw towI~xs owew• filrt P 4, aTtlnk mem..Nie suwarta sd prawtioa or srftarb..boody .d.rced tn .r.a,nrt eoranrirs. Vz de fines padicules solides ou liquides. II s'agit d'un systime -dispersE ou la phase dis- pcrsante est gazeuse et ou la phase dispersee est liquide ou solide, Ics particules dtant suffisam- ment petites pour rester longtemps en suspension. Ces particules sont soumises k I'action de diverses forces dont la pesanteur et It mouva ment brownien. La attiroiols satareh sont des suspensions daas 1'air, de Partlcules liqtrides, par exemple, les auages, dont k diamLtre des miailes sc situe aux environs de 100-M µta, ks brouillards, de diamitre de micelles de 2 1 15 Pm, ou de particYdes solides, tels ies aaages de pousskres ou nhe les fumtes diveraes, dont It diametre des micelles peut descendre jusqulk 0,2 pm. et qui constituent, en qt:eklue sorst, la transition vers
Page 664: wrm95d00
50335 3177 + o. 091 I 11eA2-81 TOXICITY OF NICOTINE TO S. P, FRESH WATER FISH (RJR81-18) File: BIOSIS (1969 - July, 1981) Prepared by Mary Jane Pugh June 30, 1981 A unit of the Nortfj, Ca Iina De rtment of Commerce `~r' Industria(I~P~c~or~ C~~t ~f ~' ~ ~ ~ ~ NICOTINE--PHARMqCOLOGY/ ~~kiterature Search N 7 e or = ~ ie -= '` - - - AI1~C
Page 665: wrm95d00
50335 3170 ii~c,Ki~TUKt NO_ 72-16 d ,{ I b •,. I - ; ~ t~ : -ft W~~~#'~~ ~" t~~~~~~~~ fM ` Afl~IRVE S - r (UgciatLs Literature Search f3e. 70-13) Ja nl:d!'y 06-9 thr sgh jura 1071. 264 CiwilGi~S P--Vpamd by P. E. iatnier BZX literature Searches are selected comIuter-aenerated bib? iograahies produced by the Library's Me.iica2. Literature Analysis aad Eetriera3 Systew {MEI3LA.~}. ~St1ect:on is aade on the hesis of si&-u.ticent c rrert ir.terest N_ the cmtJect =.tter !.'c a s-,:h:,ts+:tis.i auc:.ierce. 'ror ik~-4s purpose a tearch which o.ris''ne11y ss~~ nava been generatpd for an :s foi-=, Iated, vbotoccsgosed, and p_-iated for dissea3nation to ot:.er interested heait2x ...~-~- - - U.S. DEPARTMENT OF HEALTH, EDi;CA'Tat!!'i, j!?iD `/VEif.d~'tE Pssbl'st He2St`: Serv-ce Ntlwnal i: ali:uies Of tieaftn I !
Page 666: wrm95d00
50335 3180 YIX T+o3FiCITY OF NUTRIENTS T1eF (1970) S. P. R. J. ft2pv.o2do Tob3cco Ca. , Rc;carch cnd Product D-aveicri,.:.emt D::pr:rtmsr.ts, Science Inform3t4.on Divr'.sAcn Shi:CIaiL M11J li1LIS. B AiO. Z1UlLi,lAJa AlTi FLMId3 StIPPL~;;lri.,"t$, by R. J. fi~z;wld8 ~..L....~_ jvJ~la.bv /~- V:V. , T...... V •atDbt..{ ~ Cai:Y ~_._ •.._.. a (i/C{Dj.{rr. ! Dav27opmont Dzp2r:tMsnta, Scl-nncc InLoimatioa ~ DivioiAll, &~'Af1 IzEaFid. ~ ~ ~2iu~~tou-Sah,A.dcol: actioa of n~tatf.c~1 0 5 o 0 n025 469
Page 667: wrm95d00
y..~..~..®.~~ T0XTCTrY OF TiiE (37C= OF "2?ZTR6CEN I II EEFECT OF MeA5 CHRONIC EXP3SUftri -T0 LOW -~MRLU+TiUTIONa OF VAPORS (1968) ;FRO4- it90FWiWG- "TB3C ACID Cray, I;dward Lab T3XY.CLdY OF TI'E CS:TDES Qi IZLLNU~E'?. IIF. E~"k'ECT 0.- T:7l.,..C ~a~+a ~ ,i ~._s.,i::~.::ati.~..r,.+` -r n C~3: .~ :7l.C k.~~J *. 1t~ IAW Ct,~Fa.~11C:~t3 C~x i~rLOP. FROl4 AW F'u=1ii5G 1iT?.IC ACID, by I•n:;aurG L--u Gr&p. StRnlty B. Go1d"acr&, and Frai:.c::.s ti. Fattcu `xch. Ina. Hyg. Qccupationai t.fA. 10, 4231-M25 (i-do 5 4)
Page 668: wrm95d00
_.. ~ - -- W-•- ~ • ~ 0~:i7) ZZ~--Rl# WT'Pg34 r=oT3ednz3t? 'SdH 'PuZ '40a-V u,oTdwA v:!a3 pcca ,~ ^-S `UcI:°J •R sTztr~IJ ':fV!!) qs''I ?zTm~`l ~'y ~'S~ yq4Ta7 T.rY....~. ~'~J ry7+Y.7 s1~t~r.-•tP;{ Q2-}.it1a T ~t~rr,~l Q. ~±e~Sr u.i n S1 MiT 0, •`'1 a...v~' .,. a,uaci u.as~...s ~-~"~T SP•r' '~(F i!iJ!.~a~ T' 8Sg n~':r~T ~T"Y n-.~r- 9 ~a1..aa..+~~.' i:I 1".:a 7~ J ..a.~i.:....L-'r. ~jL~f. uY .: J t-..'.:.. L•o MyA;1 C-Ij ciw:.a:1A~j.r I ~. . ~T'~IIT~'~IH2~l ~ :,`V "3TtI~il~ (9961) ,' 181E SEECS
Page 669: wrm95d00
, 50335 3175 . L. III MeA7 -81 S.P. Archiv fur TuxikoluKiu, 20, •1a5-241 11UW) _ 7OXICI-TY OF 1ETMYLISOCYAIiTE AND ITS WAMTITATIVE DETERMINATION II1!•ux'd81d 71AA>fugiuclwu und (,'uwarbuliygieuiu<diun luntitut der b'urlwnfabrikutn liayur A(:, Wurk N'uppertul-raberluld (luitcrc Prof. Dr. mrd. (L HtccuT) Zur Tuxicitut von bietllylibucyanat und d(sssen quantitativer Bustinlnlung in der Luft von Il. j{IMMF:xLIE und A. M:uEN Mit 2 TnxtabLildungen (Einyegangen om 2. Ukk&r 1'.163) In don letzten Jahren hahen aliphettieche und vor allem arumatinche Ieoeyanate eine grul3e teohnieche Bedeutung gewoiutun. Sie werden in groBem Aueunal3e in der Lackinduatrie, Gummiinduetrie und bei der Herertellung von Schauwnetuffen verwendet. Bei ihrer Verarbeiturtg nind gesundheitliehe Scha(ligungen vorgekommen. Diene zeigten sich nach Inhalation dieser Prudukte ale Reizung der Atmungtlorgane (Bronchitin, Pneumonie, Asthma brunchiale-ahnliche Zuetande) und durch primare &:haden der Haut und anderen Schleimhauten bei direktem Kontakt. 0 5 0 Q t1 0:2 5 4 6 4
Page 670: wrm95d00
I 73 X Re2- S.P. 50335 3176 ~ Proc. 59th lnd. Sc. Cong. : t'art 111: Abslracls 13J. Toxicity of Nicotine to Aquatic Life. ~ S. K. KotvwR, ICa1}•ani ' ' The objectives of this investigation were to determine (I) the toxicity of nicotine { qtt freshwater isbes, insects, and plankters ;(ii) the inHuence of different pH anu turbidity levels t~t the toxicity of nicotine ;(iii) the residual toxicity of nicotine in water ;(iv) the compatibility cf nicotine with an tuganophosphorus insecticide DDVP ; and (v) the histopathologicil effects of nicotine on 6sh. Eiwssays,were made in glast aquaria at room temperature to determine the toaidty of nicotine to 10 species of fishea, e' species of aquatic insects, and 11 species at plankters. The lethal concentrations af niootine varied for different species of 6shes and imetts. The Insects were aeveral times more tolerant to nicotine than fishes. The ooxicity of nicotine increased with the inctrase of pH. The tttrbidity had no influence upon the toxicity of nicotine. The commercial soda and line were found to activate the nicotine toxicity to fishes and insects. Tiie cladocerans and copepods were morr anarptib7e than phytoplankters to nicotine. Nicotine last residual toxicity in wate: within 6 d4ts in alkaline traters. Nicotine and DDVP applied together complecely centrolled the 6shes and insects. 77te liver and kidney tissues of dte exposed fishe" were severely injureJ by nicotine. O ~ n app~tn~° sder and more useful than notenrxte. endrin, and sotne blga o~sorw shtti ~ganpchlorine insecticides currentiv triee in b5nfr•, manaFrment
Page 671: wrm95d00
.1 'February 1973 Work supported by the Toxicology Information Program, 50335 3190 -Helen S. Warren ~ ~XICOLOGY INFORMATION RESPONSE CENTER National Library of Medicine, National Institutes of Health, •Department of Health, Education, and Welfare under NLM Interagency Agreement No. 40-274-71 OAK RIDGE NATIONAL LABORATORY Oak Ridge, Tennessee 37830 operated by UNION CARBIDE CORPORATION for the U. S. ATOMIC ENERGY CO*uIISSIOV
Page 672: wrm95d00
50335 3187 ; VII CoA2-76 RJR CLASS NO, PAMPHLET VII CoA2-76 s.p. ' S.P. U. S. Department Agriculture, Agricultural Research.Service, ' Washington, D. C., U. S. *Keywords:* phosphine, tobacco, additive. ~ ~ Phosphine (PH,) was tested as a fumigant ~against all life stages of the cigarette beetle, L6.sioderma serricorne (F.), in 8-cu: ft. fuma- ~ tor9ums. Eggs, pupae, larvae, and adults were ~ decreasingly resistant to PH,. Exposure of 72 ~ hours at 80° F. was sufficient to kill all insects in ~ xll stages with PH, concentrations of 100, 200, ; 500, 400, or 500 p.p.m. A concentration of 100 j p.p.m, was nearly as effective as 200, 300, 400, or 500 p.p,m. at 80° F. Overall, however, it ap- ~ pears that a concentration of 200 p.p.m. is pre- 1 ferred because higher concentrations did not in- ~ ~ crease the rate of insect mortality. Effective j ~ fumigation of tobacco with PH, may be antici- pated when the temperature of the commodity is ~ ~ above 68° F. and't'he fiumigatapn period is not less + than 96 hours. At 60° F. or lower, some eggs and ~ pupae will survive. The suggested fumigation ' time at 60° F. is 144 hours; at 40° F. it is 240 1 f hours. .
Page 673: wrm95d00
" UE:::Br.~y ~` cs cr'tit' c.if....... .t.. r i ~,:,..:.... ~ "L9 (t 9 - 14 '~ r;:fite D. o 4o id,ZL.A WElfg-6~" 0
Page 674: wrm95d00
5Q335 3193 TOJCICOLOGY--ACtTlE. TOXICITIES/FOOD--TO%ICITY/ SUCItOSE/GLUCOSE/ CAEEOHYDRATESiFATS AND OILS/PROTEINS/ANIMALS--PRARMACOLA6Y/
Page 675: wrm95d00
,~~,-, t.~'.7) =co,y •a ntra 4-QA s. :'IXIZI40l uz i~a~ ~ III ~ 681E SEEOS
Page 676: wrm95d00
FOQD--PA Ct'..wI.G/ - 74 ECII F.e R., J. Reynolds Tobacco Co., Pesearch and F•roiucr IIevelopment --"'" "-.'Departments, Science IzforWatioz iivisioa. st iPhCKAGI?.G. A COLLECTI0- 1974 -Vinston-Salem, .;. C. go 700- Food Packaging; Gene ral. '^ 701- Meat & Poultry Packaging & Central Processing; Storage life testing & factors; ~ an ~ 0 ~ Fresh fruit and vegetable Packaging. 702- Child-Proff closures for flexible packages. , 708- Non-food or Novel Packaging use of PVC fi L-:s & PVC film in foreign countries. 710- Plastic filrss & extrusion resins; Uses, properties, scrap recoverv; 712- ~ n S.e.,A .~.,~ ~t--...-,....~-~...-~..,~. - -~ 733- Gravure Inks & Coatings. 74f1-Packa in^ "aterial shortages,,& related Econo_.ics. 730- Ultraviolet, Microwave and Radio-Frequency Activated Inks &Poatings. and LabelinP. - recyclin :. 722- Flame Resistant and flane Retardant `:aterials and Compositions-. 725- Federal Legislative & Regulatory Activity Concerning all aspects of Packagin;, 721- Self-Heating Packages and Self-Cooling Packages. I- 'l28- Heat Resistant Packaging(Cook-In) 715- Heat Sealing; Equipment, Processes, Techniques. 716- Heasurenent of Adhesion; Measurement of Seals. 717- Powder Coatings. ' 719- Aseptic P2ckaging. 714- Laminating adhesives, Equipnent Processes, `:aterialS, Technio,Ues; _ - JF,luminua ttetallizing of Non-conductors.
Page 677: wrm95d00
AMM Abstract Toxicity iftta on various materials undsr• -pyrolysis conditions are presented. Synthetic pqlymers and elastomers are compared under gradual and high heating rates.
Page 678: wrm95d00
. RA 1245 Al 1977 POLYMERS & POLYMERIZATION--TOXICITY/CARBON MONORIDE/ACROLEIN/INHALATION/ POLYVINYL CHLORIDE/ DISSERTATIONS--UNIVERSITY OF PITTSBURGH/ Toxicolf gical Feb. 1977/] Methodologies to Assess the Relative Hazards of vthermal g 6. Performing Otgac Decomposition Products from Polymeric Materials. 7. AUTHOR(S) Alarie, Yves and Barrow, Craig Stewart, 9. PERFORUIhG ORGANIZATION NAME AND ADDRESS University of Pittsburgh Graduate School of Public Health Pittsburgh, PA 15261 I12. Sponsoring Organization Name nnd Complete Address (Street. City. State. ZIP) • t 8. Performins Orga, 10. Project/Task/"+ 11. Concracc/Granc Grant 5-90( 13. Type of Report Covered Special 114. SponsorinR Aae: Sensory and pulmonary irritation effects of therr.al degradation products fx T natural and syynthetic`materials were studied using mice. Mice were used tc develop a sensory irritation stress index based on changes.in respiratory z In addition, acute lethality was obtained. ' National.Bureau ot Standards Department.of Commerce Washington, DC 20234 i. . Dose repcese0r_-u*eGw4e %en&aAd Aor decoaoosition 'products from Douglas
Page 679: wrm95d00
ByDOMINGO M.AVIADO 1. 2 3 This report summarizes the available information on the toxicity of '15 propellants used in aerosols. After reviewing the results derived from various loroethane and methylene chloride. . Low prersure propellants of highh toxicity: trichloroiiuoromethanc (FC 11), dichloromonofluoromethane (FC 21), trichlorotrifluoroethanc (FC 113), trich- animal species, the touownng ctassrtications are proposea: "Low-pressure propellcrnts of intermediate toxicity: dichlorotetra8uoroethane (FC 114), monochlorodifluoroethane (FC 142b), isobutane and octafluorocy- clobutane (FC G318). High pressure propellants of intermediate toxicity: dichlorodifluoromethane 0~0 0 0 0 2 548 1
Page 680: wrm95d00
50335 3183 . Brit. J. indot'r. Alyd.. 19SS, 12, t,t1.-Sl Y1Q- vJ 1 1 , .. ST, BY . W. M. DIGGLE and J. C. GAGE Fiaa Ore Imperial Clrenrlcal Inrtasuries Lttt., ha4euria! Ntsiene Rr.aarck Lalanratorie.c, We/wyn, Hertz (RF.Ctitv[D FQR rUSt.lt"AT1pN 1VOVEMaER 15. 1954) 0 In a pncvious paper we (Digglc and Gage. 1954) have referred to published statements that the toxicity of ozone is incrcased if oxides of nitrogen are present and we have suggested the hypothesis that if, in fact, this is so, then the increased toxicity is likely to be due to the presencc of nitrogen pcntoxide, to which the lower oxides of nitrogen are convened by ozone. As a first step to establish this, we undertook a study of the toxicity of nitrogen pentoxide and we demonstrated that it is a" lung irritant " gas of high Potancy Sittoe the appearance or our paper, a careful review of the litet:ature on the toxicity of ozone has been made by Stokingcr (1954) from which it is evident that although there is general agreement that ozone au$ widb vaRat o~s incncg oncenStrrationse~ hre ts necessary to prodqgatbM ;: _vmptoms. oxygen was allowed to leak at controlled rates in the region of 20 tnl.lmin. into a strcam of filtered air which had been dried by means of a silica gcl column to a humidity of about 10"„. Analytical control of the ozone dilution demonstrated that provided the flow rates were maintained constant, the ozone concentration of the atmosphere produced remained constant for the duration of each experiment. The ozone dilution passed through a 5-t. mixing vessel and thence to the exposure chamber. The exposure chamber wac constructed, as described in our previous paper, from a 20 1. glass desiccator ; the in{ct and outict tubes were sealed into the chamber by means of polythene bungs and all flexible connexions in the system were made with polyvinyl chloride tubing. The nitrogen dioxidc-ozone mixtures wcre prepared by adding nitrogen dioxide to the air used to dilute the ozonized oxygen. Pure nitrogen dioxide, prepared as previously described, was passed into a flask cooled to ' -80' C. in a solid carbon dioxide-acetone freezing mixture. A proportion of the air stream, according to
Page 681: wrm95d00
50335 3196 CARLQS I HILADO. HEATHER .I. CUMMING AND COLLEEN I CASEY Fin Safety Center t/niversity of San Francisco San Francisco, California 94117 XXII MeB9-79 S.P. ABSTRACT: Toxicity test date on 95 i.mples of plastics and elastoniers, pyrolyzed in accordance with the USF toxicity screening test method, are presented. The samples consisted of 50 samples of solid polymers, 16 samples of solid elastomers. 12 samples of rigid cellular polymers, and 17 samples of flexible cellular polymers. Data were obtained using the rising temperature program from 200°C to 800°C, and less extensive data were abtained using a fixed temperature of 800°C.
Page 682: wrm95d00
1 CARBON MONOXIDE/ INHALATION/ , XXII ReB8-79 S.P. 50335 3195 CARLOS .J. HILADO, NANCY V. HUTTLINGER, ANDDIANA P. BRAUER ' lournal ojCOMBUSTlON TOXICOLOCY, Vol. (November 1978), p 3([[[0 F~e Safety Cente -3r Uni~risty of San Fra isco ~ Sar~ Francisco, Califoa 94117 ~ Oripitlal manuscript received July 22. 1978 Revised manuscript received September 20. 1978 ABSTRACT: Special reference samples of phenolic and isocyanurate rigid ~ foams were evaluated for toxicity of pyrolysis gases, using six different test conditions of the USF toxicity screening test method. The test conditions ~ were 200 to 8oq`C rising temperature and 80f7°C fixed temperature, with- out forced air flow and with I and 3 Vmin air flow. Under rising temperature conditions, the phenolic foam appeared to be consistently more toxic than the isocyanurate foam; this may be reiated to _ the carbon monoxide level from the phenolic foam being approximately - twiCE'thi CO level from the isocyanurate foam. The temperatures corre- . _lponding to the times to death indicate that the toxicants from the phen- c olic foam were evolved at temperatures below 500°C, and that the toxi- cants from the isocyanurate foam were evolved at temperatures below B40'C. This temperature differential is in agreement with that observed in Q~ o~itt~yrgh~lata, which showed that lethal toxicity occurred 44T.a^~r for the phenotic (oam and between 565 and 8WC for the isocyanurate foam. i
Page 683: wrm95d00
50335 3165 . /ORGA230PHQSPIiHRiTS:.COt•Il'OLJNDS/INSECTICIDES--METABOLIS"kl/ LITERATURE SURVEY RA ' 1270 Cr ~ NT I S/PS-7S/756 ' t ~•z 1975 A B_i~ liot;raphv ith Abstracts Y- "°`h°`rS` 1 Pernell W. Crockett ftearch period covered ?. Performing Organization Name and Address National Technical Information Service 1964 - OctTy~-ober 1975 5285 Port Royal Road Supersedes NTIS/PS-75/009 Springfield, Virginia 22161 . Abstracts {2. Sponsoring Organization Name and Address Same n tiona!~ ntiona! Technical Information Service~l YJ M~ ' ; OE COfafIFlfERCE (t) ;~ t~DEPARTPTEGfI ~ Virginia 22161 ti~~=~ SNnngfieid , A. .7 __9 itesearch reports on the toxic effeLts of pesticides on non-target organisms are cited. Included are studies on the biological effects on humans, wildlife, and aquatic life through direct exposure, food chains or degradation products. Speci, emphasis is given to research on the inhibition of cholinesterase and other en- zymes. (Contains 188 abstracts)
Page 684: wrm95d00
-----W'~`"-Z. III na--7s ~ 1A is .?z a •.SS$ 1112. Jap. J. lad. Neafth. Vol. 17. 1975- . 0 5 Koichi Koh•o+ Fluorocarbon el:sbomer has been desvloped for the purpose of application in some industries and is used widely because of its excellent thermal stability and chemical. inertness which are not to~d in other ela_`tomers. When fluorocarbon etastomer is used under a high temperature beyond ks haat-resistant limit for long hours, toxic products are suspected to be produced, and it is important to sdtdy the mechanism of the toxicity of this pyrolytic products. Having pyrolyxed the copolymer of vinylidene fluoride and hexafluoropropyiene which forms mae than 90 per cent of Huoroelastomer, the author analyzed its elements with gaschromarography, G.C. man spectrogmphy. infrared spectropbotography and biochemical assey, and examined the pincipal toxic factors by means of biological exposure in order to establish the industrial safety .Candards. Gas cott[poneats, yielded on pyrolyzing processes of fluorocarbon elastomer in air, were different froea those in nitrogen atmosphere, and were composed of many infiredieats such as hyrirogen ID 2 54 B~O .
Page 685: wrm95d00
9 50335 3208 T 55 An 1975 3c. 0 F.ditors and ConJerencc Charrmcn IRVING J. SEi,IKOFF AND E. CUYLER HAMMOND /VINYL COMPOUNDS/ VINYL POLI'MERS/ TOXICITY--CHEMICAL CO:KPOU:dDS/ ANNALS OF T1iE NE\Y YORK ACADLA7Y OF SC1ENCLS VoLUnlt 246 January 31, 1975 0'5 0 0 0 0 2 5 4 9 7
Page 686: wrm95d00
I 50335 3150 FOOD--COLORS--TOXICOLOGY/ 5 -77 j'Jour. Sci. Ind.Res. 34~~11JQQ975) ~- XX eC iS.KHA-~tAtG.SST•CGH Itwestrw Taadoslop Aessrd! Cetae, La2ka. • It T HE processing of surplus perishable food the present Faper are aaording to Indian speci- produets tc•r presen•ation and faeilitating fications. thetr marketing has become a rujor indtutn Toxiaty of \oe-permitted Colours in oas countries. The use of eclours is essential fos testorins the otieinal shade and freshness lost AsnrrMiue (CI Basic S e1aGW 2(41000)t - A surrev dorutg processin;. Coloration of fresh food pro- of workers en:aged in the manufacture of auramine dncts is also being rescrted to more and more for in Britain during 1910-1932 shcw•ed a statisticadh- makinb them aesthetically and psychologically significant increase in the m.mber of deaths cue to atttaetire to the censumcr. bladder tumour ccmpared with the tncidence of Aoyama rl &l.r stuJied 3744 stw-iles of artificially deaths due to bladder trmour in the general eolonred food and found the presence of the non- po~tion4. petmitted colours rhoda:nine, anranrine and mala- Male rats fed auramine (10 m;/I:g body w•cir,ht) s$ite green in 42-6. 22•3 and 3•8°•; samn:es respec- daih for one year showed r;row•th inhibition, hepatic tively. Analysis of the dyes used for colour-ca-finr dysfunction. marked damage to kidnec• tubules and meat in \e.r Zealand recealed that first and third increased trrartality tates. A hypotettsit•e ecoct grade meats were marked with magenta and was seen at letels of 1-3 mg;kq body w•eicht in attaamine respectia,eir. Second grade meat was rabbits, thcngh dogs and cats were less sensitive•. aith aiolet 3 B\, benzt•l violet 4B and Long-term oral aiminis:ration in rats prociuced ~iokts. S:ndies conducted at this rntre subcutaneous fibrosarooma, hepatoma, :ntestinal al n575 samples ef coloured foodstuds revealed carcinoma, kidney adenocarcinema and tran<_itional that 70% of them contained non-rertnitted u+lours. cell carcinoma of the urinary bladderr. Fcedinr; Ue six most commonly used colours were fotm:l to of 0-1°/, auramine in diet for 87 weeks resu!ted in oeeor in the fcllowinsj order of frequency: metanil the development of liver tumours in 92% ratsk yellow (29!e), orange II (11 ;;), auramine (91'0), Subcutaneous injection oi auramine :or 21 ::-eeks Apdamine I3 (S°e), blue A'RS (60,0) and ntala- (a total dose cf 110•120 mz) procluced liver tcmour eldte green (40,;)• Besides these, acid tnagen:a, in 1S°a and s+tbcutaneous tumour in 53?; animals. v 0 • nt ece~sca~ b•.a~er t'~low~ngo red, Blue VRS ZCl Food Blue 3(4204i);-3tii+crs olr , m yl let,~phj~l y K, ni8ro- taine3 some evidence of increased incidence of Ieu- t_. sine,onion}•e;o%r. red 6B, sudan 11 and sudan III laettuainfemalemiceatteroralortopicalapr!ication - ~ ~i...i. :~ a . . .
Page 687: wrm95d00
50335 3198 SELENIUM/TOBACCO--SMOKE--'ANAL1fTICAL METHODS/' 73 X Re2-81' S-' pl- 8.?g C1ASS NO. l1lMPH.ET 73 % Re2 81 s.p. 3aveja, A. K.• 6upta, V. 1C. (S,avishanlcar Vniv., Dep. Ches., Raipur, India) ~ eLeyvords:e selenium, s.ake, constituent: T6e use of new reagent for the detection of traces of selenium in cigarette smoke is described. The method depends upon the reduction of selenium present in the smoke into the red elesental selenium in a hydrochloric acid s,ediu.. This is extracted in isoa.yl alcohol to give a red coloured suspension indicative of selenium. The sethod can be used to detect up to 1 pg/al of selenium in a 5 nl sa.ple. •3'be method is fast and free from ilioerference by substances present in cigarette mofue.
Page 688: wrm95d00
Paper given at the me ting of _ the Awe•ticafl Indus. trial Hygiene Conf erence, Miami, Florida, May 1974. Morris V. She3ansla, M. D., C. M. * Theodore Levenson, Ph. D. ~ Robert A. Scala, Ph. D. ** -~ aF'ood and Drug Research Laboratories, Inc. 1.51 East Tenth Avenue Conshohacken, Pennsylvania 19428
Page 689: wrm95d00
I 50335 3197 ,7ournal of COMdUSTION TOXICOLOGY, Vol. 5(November 1978), p. 361 -3&9 CARLOS.J. HILADO AND NANCY V. HUTTLINGER Fke Safety Center University of San Francisco San Francisco: California 94117 7IXII MeB9 79 S.P. Original manuscript received July 15, 1978 Revised ntanuscript received September 18. 1978 AA_77- .e ~ .7y T ~p ABSTRACT: Nine samples of synthetic polymers were evaluated for tox- Icity of pyrotysis gases, using the tox icity screening test method developed at the University of San Francisco. The materials were polyoxymethylene, polyethylene (five sarrples), polypropylene, polymethyl methacrylate, and potystyrene. Of the five polyethylene samples, three contained known levels of chlorine. These test results were combined with earlier data to provide a comparison of 25 samples of synthetic polymers. - PWyoxymethysene appeared to exhibit the greatest toxicity, and poly- styrene the least toxicity, under these particular test conditions. ~500 0025486
Page 690: wrm95d00
I I ~ 73 11 Wa TQ NOME ~- . . ... ..,:: . _,. _.. - : .~__-... . . - f J. R. ~•'ati~land2/, F. S. Davis ~ and "~t. G. !ferkle?~ b4artments` of Physirs , Range Srcience, Soil. and Crop © Texas A&M University, __ College Station, Texas 77843 - ; . . .. • r.• . . - .. , . ~ . ~S> ys Sciences 0 5 0'0 0 0 2 5 4 9 4
Page 691: wrm95d00
50335 3209 Melq 1~.T~ 1~CyeoYds >_ : :::_..: Resea~ch _ :: f°rt~#uc~ Devela~ sa+r ; < < : .: 'A# 7bXZCY'[X OF XN6X . ~ . LLTE'RA'riJKE $UrqvEY: ,3• A:e ypoCd t.: . /tts e.~rc h• r+d PhodL.y. Qr~d i3~1/.i.aw xlY MC~.r 111,7 w wl~l WS fl 5 0 0 0 0 2 5 4 9 8
Page 692: wrm95d00
50335 3206 NTIS/PS-76/0197 1964 - Ma rch 1976 l9f,1<- ~~ 47q 8. 1'er(ormiux UrK;[nri.rnoq !i[1•[. No. ~~. 1'.r/.1rminx (1rF..ni-r.wciun Name and Address 10. Prujcer•'T.[sk'R'.,rk ijew N•,. j National Technical Information Service ~; 5285 Port Royal Road :.~~.. 11. r.on[rac[!(iran[ N.,. ~ ! •Springfield, Virginia 22161 ; Research is cited on the health hazards from exposure to vinyl chloride and vinyl . chloride resins. Studies are included on the epidemiology, industrial and public ~ exposure to the compound. and its degradation and combustion products. (Con- tains 36 abstracts) Metional Technical Information Service 7iy A Bibliography with Abstracts Search period covered 17•tditor: , t Pernell W. Crockett U.S. DEPARTMENT OF COMMERCE ~:r^ Springfietd, Virginia 22161 _ 0 .5 00~02~ -
Page 693: wrm95d00
50335 3213 ., , FIP•E/C0'~liUSTION/CARBON MONORIDE/HYDROGEN CYANIDE/PLASTICS--TOXICOLOGY/ RA THER*!AL ANALYSIS--ER,~LiPNxNT/PYROLYSIS/ PHYSIOLOGICAL AND OFi OMBUSTION 24 1 5 Na 1976 INTERNATIONAL SYMPOSIUM , March 18-20, 1974 w/Flamnability Research Center The University of Utah Salt Lake City, Utah Conducted by COMMITTTF AN rIRE RESEARCH COMMISSION ON SOCIOTECHNICAL SYSTEMS NATIONAL RESEARCH COUNCIL NATIONAL ACADEMY OF SCIENCES , Washington, D. C. PRODUCTS: 1976 0 5 0 0 t1 0 2 5S 0 2
Page 694: wrm95d00
l- Sz 0 u 0' 0 S d #3 •u 4=vj~=vuPA 2~'f xn$~3j ~!f IIG'3"sy ioo Y $947 sttMkj r 'M Au'LEUM PUs UoTITA90 t"I3wjlzo3uI ZZWJTos ~ !7 ;2I:~''~3$Ga ~ `f~.`Q'fi's&O'C24Za 2t3:F'7i7sa "3 q-a.4vFr'^uy, 4tPloui3;; •S' ~ A-1 'fi~;.'T!?a ....;.l:i~.l ~::.t~.i l • .Clt;~`f~fM.l1JS 5...~3 ~~,:~ l3V •'1-ts.1.a:~cl,r~C1 . r t9~~~~~ s',i.;l::~~~~d:,~ ~~, 3ix3a rr_zII y::~ii'?;;e:~ •d•S ~ti~ z~x~~~<<3 'asz~d~.~ ~~.rs;~y~ ~i:; ~~°T •C 0'('696T) Ldaly ~}i~~ ~;~ ~t ~ { f ~ ~ ._ ~ •, R• ~ ~BS~ _. +~.«:%'~~U: .~~~~~I:L6d.. I T I EOZ£ SEEOS
Page 695: wrm95d00
:.. Ipd. Hyg: J. 1961, 354-361 (1961) XXII MeB9 76 S.p. 50335 3207 T. R. TORKELSON, Di.S., F. OYEN, aind V. K. ROWE, 11LS. Biochemical Reaearch Laboratory, The Dow Chemical Contpany, Midland, Michigan Groups of laboraton- aninials were exposed rcpe:stcdh• for up to six months to either 5U0, 200, 100 or 50 ppni vinyl chloride in air. Detectable ch;inges occurred at all but the lowest concentration. The results are dircussed and handling precautions su;;ested. lntroductan . VI.\YL thloride (CHi=CHC1) is a chemical of great industrial importance. It is used in the preparation of poI}-vin~-1 chloride re_in, as a copot3~mer in saran and other pla:ties, as a c i~l interu~dia~ a~ as~a ~lrc~t. F3e Q 5 - se tl~ai,Qab r s-it1'~1 ch riclP, it has been rener:tlh• assumccl t h:=t ° },A > -:- : -- , . The following report summarizes the rc--.. of repeated exposures of laboratory aniniu'.- either 500, 200, 100 or 50 plun of vinyl c1tlc: The significance of the rc:ults is discussed . recommendations for a threshold limit Valuc made. Experimental Procedures
Page 696: wrm95d00
, 50335 3212 III i)u -73 FARMACG PRA. 27 (9) (.1912)51Q-22 - S.P. 2 E. APOSTOLO - E. LANZAROTT[ - P. ZAIA in Italian with Englisrh summary YfSTWS QUALITY CON[ROL LASOS:ATORIES - CASATENOVO (CORfO) - ITALY - SUMMARY. - A study was niadc to evaluate vaginal irritation produced by an intimspray aerosol in rats, injected iniravaginq.'ly with a constant volu- me of product. At established periods the animals were sacrificed and the vaginas dissected out: tlee organs were fixed and sections were stained by the haenFatoxylir:-eosin technique. RTicroscopic imvestigaiion was made in order to evaluate mucous mem- brane modification; untreated rats were used as cor.trols. 11 o s o 0 0 02 5 5 0 1
Page 697: wrm95d00
. Files: I. Toxicology Data Bank (TDB) (1980 Edition) II. Registry of Toxicological Effects of Chenicai Substances (RTECS) (1980 Edition) III. TOXLINE (1966-m4Y 1981) Rrepared by Mary 4ane Pugti Orme 29, 1981 (RJR-81-16) ~ u~t ose I~tlinn ~etme~nt of ~ ~ , sndustriat App~icac6oY~ ~ r the Nabonai Aeronautics and ¢^ 50335 3204 s vLiterature Search ft. 7085 TOBACCQ--tUMECTANTS/
Page 698: wrm95d00
73 X R:2-8A Jonr. Food Safety .1 (1979No.4 275-93 S.P. s4rudes have been made in identifying ea.ironmental and work-related potWfmn'6t'jhat s:e`potentia[Iy carcinogenic. However, there has been a s%piticant bg in identifying the relationship between diet and cancer adafW. This lsrk of information includes both data on the relation- . I ~ ddD between dietary statis and susceptil~itq to carcinogens, and the f~Z .~--- a ~ /~r;!~~ s~~tJ sWs Cole'f fi~dietary comgonents that have carcinogenic - 14pt~bpec " ~ t~c~ tl~~r cateqory, adentifnc and governmental intemest A REYIEW ROBBBT L. BUCH/INAN 11qwfeecnt qf Nntrftfoa & Food Sciaeea Dnprs! ifnicWtity lRjfsdekAi, Penno-lawi419104 Rsce;.ed tor Pnblicatioo 3iqr 15,1979 IICMDUC?ION K-wing the past senerai yeus, there ho been an intense study of the JW at6oiogy of cancer. As a result of the President's "war on cancer," great ; ~~~ 'tAer ~%_.; - ~: ciirF_r._te~ u~. ~•a•rcs inynxigations of foai addizives
Page 699: wrm95d00
J(KtItNAT. OF I'a'ONCTMT(t 1'.NT(IaUNAK:Y Vt)l. 44, N0. tATjJFa-3 ltOY TtAN[SpP.RKY, 1114sr•a, and L. 11. Neemm, cereeb, Nen York ru a rercnt. luelier, the writers ((Ians- ln•rry & Ncirtem 1940) rrlNertvd an the tuxietity nf c c•rluiee nicY,tiue eonitNeeuul+ sul- mini.trreti( intc•rnaelly tn xc•.•rrael xtx•cirs nf iTUsee•1.. 1u the ierru•nl. auely a lurgn-r grUIT}i f/f Knt'll t_'pT1I(KlQINI?i has INY'tl tested as ccrntsict iti+cc.lirich•.r sef;aiuxt. Apltix rumicix 1.. nndrr lutK,ratury cymclitinnN. A futurc I):elx•r will deal witle fiie• tecxiciticr of these cnnilxinTIds fu newly hatcbcy) cYxl- Iiut; Tnutli laervae. The ele•tc•rminat.iou of the rclnt.iuii of chcmical ancl physical prcip- .r1Tat is apparently a colloidal u>leilion in water. It len.s wnm• wrtting aeid spreading protx•rtics in the leighcrcnneK•nlr:etinns. Nicotine ;frr.rl;rl, Y1.{8 IH•r ca•nt nirn- tinc. Furnislud by the \fnn.:u1to (:hrtn- ical GmTpany cd tiaint t.cnTi.v. Apparcntly a cnmtx,nncl of nicK,liiic with uuT alkyl plecnyl Ixmr.c.nc xulldHCUic acid. It hMS ~,*txNl {YCttttlg and xpre:uling properties at cemccntrntic,ns toxic to aphids, and is caxily d6x.cdvcxl or ckqierxc•d in water. 1`'icotinc ca.rinatc. 2U.GI' per cent nico- _•__------'- ._a.. 2 . . ..,_._n..fl_) I I § ... j ...
Page 700: wrm95d00
50335 3214 ~ BO 7 Boe,e x y, F. TOX,z~'.GLOGISCV~ ~FSt*LTTE DS P.AITCF',EM, (Tox~ cologf caI Agpcets of Tobacco SmakSn,g.3 tlmsctau 1963 th, 2) 3T-42 (Ia63 0 5 0 0 0 0 2 5 S`0 3
Page 701: wrm95d00
~..., .e,.~...,........,....:~.... ~r ,~~.DLSZ"•~s s.P. 455 A" CONTINUING REASSESSMENT OF ISO- ~~ENA~iNEAEROS arson, J.Scheimberq~ ' t I : Mackars ,+nd-V_ E VoPin. F ood and Drug Research Laboratories, Inc., Maapeth, New York 1 1378 Recent clinical reports suggesting that increased asthma ~ mortality is a direct consequence of the use of Isoprenaline aerosol dispensers has caused reassessment of their use by elinicians, drug firms and regulatory agencies. lntensive toxicologic studies with rats, guinea pigs, dogs and monkeys ~ at dosage levels far in excess of current commercial metered ~ dose vials and utilization of several commercial sources of solubilized, as well as powdered Isoprenaline HCl have not ~ elicited similar adverse responses. Ecposure to pure ' aerosols without frank and possibly marked impingement of ' the buccal mucosa at levels up to 1. 5 mg per kg cause little or no mortality and no significant electrocardiographit, preasor nor adverse respiratory responses. Exposure of ~ I to 6 hours tolhese concentrations represents very large increments over clinical dosage equivalents. Complementary studies in cats exposed to particulate carbon (50 and 70 mµ, monodispersed) and C1s-labeled Z-50 µ corroborate alveolar deposition and pulmonary exposure. Data suggest the need for rnore carefully deliaeated studies isolati th ibl ag e poss e , ~ effects due to direct impingement on mucoas and subse- quent wetting (buccal absorption) as opposed to exposure to the aerosol phase alone• IneLiow in pertusion flow rates are aasumed to indicate emisr eomtriotion. Suppprted by arapt /'Ef.00?,3L-OSPNS. 4E4 f PIIAf1h1ACOLOGY ~.,,-..,... ~. .. . . -~.,,. - 9:00 A hf , 1 ,. L^ t - Itoont 1 -311 i rcrlinc 453 ttRDIOYASCi8.6R ROLL IN OXYf:Dt TOXICITY. C. D. Woed, Perklns+, A. 6. Smtth*, and J. M. Reaaxs• LSU Sch. .i• in 5hreveport, Shreveport, La. 71101. . )osure of rats (Sprague-Dsuley) to high pressures of 100% ;t et 2 to S atmospheres absolute (ata) resulted in a ; pulmonary edema. At S ata the survival ttme averaged jt. Fasoral arterial pressure averaged 200/180. Pulwm- toous Dressura of over 30 er Ng uas recorded in dogs. - results were cosqared vith pressure recordings in rats ;lch hypertension resulting in pulmonary edema was pro- + by injections of acontttne into the anterior hypothala- ~ 7he blood pressure reeordings, the gross and icroscopic ~ss in the lungs were all similar in the pulmonary edema :ed by both methods in a double blind study. Rats ex- to to 1002 02 at ambient atmospheric pressure for an aver- t' 7"2 hours developed a fatal pulmnary edema with massive :ti effuslon• blood pressure recordings (tail cuff) indi- t no period of.bypertension• Microscopic examination of {sags shoued all respiratory areas to be filled with edema j and up to 17 cc of pleural fluid. These ehaoges are tr to those ia clinical left ventricular failure. It has •eported that AIY is inhibitN by inereased oxygen. Our Ieh indlcates that the major changes in the lungs seen in exygee toxicity may be accounted for by cardiovascular reapoo- ses. (Supported by VA 6lrant 101/9200.1/69-01•) oso©0 0 2 5 4 99 ~.~ k
Page 702: wrm95d00
f I 50335 3211 .1. FIRE & FLAMtiABILITY, A'ol. 1(Ju1y I9i0), p. ?39-2(og 72 III Au1 , ~n~.b.c~s~~-on Jo# __~ly~rserfc-~4t~ter'a1s ~ - ~ Jonn autian Materials Science Toxicology Laboratories University of Tennessee Medical Units - Memphis, Tennessee 38103 Each year fires kill thousands of persons, injure several hundred thousands and cause direct property damage running into the hundreds of millions of dollars. Since the advent of synthetic poly- mers for textiles, house furnishings, construction material and portions of various types of vehicles, the fire problem has taken on yet another dimension-that of the possible toxic effects from the degradation and combustion products of new man-made materials. With the trend toward greater use of the5e newer polymeric mate- rials for all aspects of life, from clothing to space vehicles, the toxicity aspects due to• fire and heat must be considered as an Important facet when new materials are to be considered toc a specific application. This article looks at the toxicity problems which may result frorn the burning or heating of manmade pofy- 0gneff mr-It025 500
Page 703: wrm95d00
50335 3215 , . -A " ToxkologY,~ (1977) 387-390 XX MeC5-78 S. P. pElserier/North-Holland Scientilic Publish N I If ~' CW We have noted with interest the publication in Toxicology of the paper by Longland et al. I 2j dealing with the use of in vitro hydrolysis procedures as a basis for determining the necessity for further toxicological studies of flavouring esters. It is worth reiterating that the Joint FAO/WHO Expert Committee on Food Additives [2] have given the opinion that if evidence can be produced to show that an ester is readily hydrolysed by mammalian enzymes to constituents whose metabolic fate and biological interactions are fully understood, further toxicological studies may not be necessary. We are aware of both national and international activities relating to the - regulation of flavouring substances and of the need to provide biological iuformation in this context. In order to avoid possible duplication of experi- l k f hi i ~ menta ef ort we ta e t s opportun ty to bring to your attention the find- ings of preliminary investigations undertaken under the auspices of the : International Organization of the Flavour Industry (IOFI). The studies, ' which were carried out independently at the laboratories of. CIVO/'I'NO, . Holland [3), were designed to establish the relative rates of enzymic hydro- lysis of 26 esters of organic alcohols and acids of various structural configu- rations, chosen on the bases summarized in Table I. 0 0~~~ s 4sed a preparation of pancreatin (Merck 7132). ,...., ,,_..-...- .. ..~ _ a _ _ .. _. Incuba ons were made under arbitra,i
Page 704: wrm95d00
u - ~ _ -n.Ak," 50335 3218 Bernard L. Oser, 108-18 Queens Blvd, balancing of benefit against presumed or suspected risk. Scientists in and outside governments, here and abroad, are addressing these problems. Differences in experimental findings and regulatory decisions will need resolution if-public concern is to be abated. (The above'abstract was intended,for a paper to be presented at the 1978 Meeting of the Division Of Agricultural and Food Chemistry,in Anaheim, CA. *It was not given, because In the past decade, the American public has seen the banning or , proposed banning by FDA of the entire group of previously approved non-cal©rigenic sweeteners; cyclamate, aspartame and saccharin. This unprecedented reversal has been motivated for reasons funda- mentally based on toxicological considerations, in part mandated by sified. Yiethoaological'probieAs-t&aer"crif.TSk3''iEvibw'eBfi8eEA" tfid choice of appropriate animal species from the standpoint of metabolic similarity to man; test dosages in relation to human use levels; the "maximum tolerated dose" in studies of transplacental carcinogenicity; _ the collection and evaluation of epidemiological evidence; and Fore`st Hi11s,N.Y.-1r-175 XR MeC7-79 S.P. ACS changed.to date of the meeting.) O.5 0-_-O 0a 25 So. l-
Page 705: wrm95d00
RA 576 I[In 1979 l 50335 3216 OCCUPATIONAL DISEASES/NITROGEN OXIDES/ POLYVINYL CHLORIDE/CARBON MONOXIDE/ DUST/ METHYLENE CHLORIDE/ - ~ ` ,Ahe J Proceedings of FIRST ANNUALdN_1OSH SCIENTIFIC SYMPOSIUM 1978 Editors: KENNETH BRIDBORD, M.D. Director, Office of Extramural Coordination and Special Proje• National Institute for Occupation, Safety and Health 5600 Fishers Lane Rockville, Maryland 20852 ' Sponsored by The National Institute for Occupational Safety and Health Center 'for bisease" Control ' Department of Health, ~ 0 5 0 r~ n2a S 111/ ,, w",V,~A ~~ JEAN FRENCH, Ph.D. National Institute for Occupation Safety and Health 5600 Fishers Lane Rockville, Maryland 20852
Page 706: wrm95d00
I ~~` y 50335 3219 i -.~.~ : . _._. (/97,P) S. C. PACKHAM. R. B..IEPPSEN, J. B. MCCANDLESS. p~ T. L. $LANK AND J. H. PETAJAN Salt Lake City, Utah 84112 University of Utah Aepartment of Neurology, College of Medicine Flammability Research Center and Original manuscript received August 5, 1977 Revised manuscript received November 12, 1977 lNTRODUCTI ON HE PdosLEM OF determining toxicological impact of combustion products has . Tprecipitated two major international symposia in the last three years [1, 21, atong with frequ~et p po d utions, meihodologies, and protocols [3, 4, 5, 6, sc'• °`- 0 7~ T~nicc~ duRi~~~ e~esented themselves to event _ ^ invofved in t--
Page 707: wrm95d00
50335 3220 RA 1199 Hu 1977 ~ Proceed' gs of th _ ternational Colloquium t/L~uxembourg, December 1976 ~ - ~a;,orY W. J. HUNTER and J. G. P. M. SMEETS tHealth aW S+f'aty Ilitectorate, Directorate,General Social Affairs, i Commission of the Eur wearpCommunities J Coilpquium organised by thKommission of the European Communit HgC1th and Safety Directorate tn coliaboration with the ternational Academy of Environmental Safety, in Luxembours, , i)l4:ember 7 and 8, 1076. Published for the COMMISSION OF THE EUROPEAN COMMUNITIES g 0 o 0'2 550 by PERGAMON PRESS f OX.'F'n ; . SXDANEX s!natc - •-••--
Page 708: wrm95d00
7 2 .~.~ . ~~: • .~a~. ,~~ ` ~ °~`U ~, ~ _ . s T 50335 3222 D. G. CLARK - Inreresk Research International. M usselburgh, I Nfidtothian, United Kingdom The term •aet•osol' is a general term used to describe an atmosphere containing particlc-, rvltieh remain suspcnded in the air for a sirnificant period of time. The aerosol may be a dus-. ..6e.nr srnntc. anc. nt.ta ..vA..,~.•s....r .:.,, a i . . ~• -- _....,. - - -= - - --_~.--- s-•- - - - _ _. , .-.. . - - Q 5 0 0 0 0 2 5 5 1
Page 709: wrm95d00
r._._____ C , ~ ~~ <ly ~ ---- ~ ~ ; J ~~~9, UJohn A. Thomas, Pht?• d Charles F. Kegley, PhD- 410a{tr4; v~-G.:~yn yy3-`~~sly ~Ad 416 i c , c: /. ri 4. 1- f/4 rrl ,, A recent television commercial opens with the Aviado' recently reviewed the literature on halo- remark, "Get off the can and on the stick." The carbon propellants. These compounds in gaseous form commercial attempts to capitalize on the public's are toxic to the cardiovascular and bronchopulmonary increasing awareness of the dangers of fluorocarbon systems (Table 1). Most aerosol products contain one aerosols. Environmenlralists are coneerned- about the high pressure propellant (eg, chforopentafluoroethane) effects of fluorocarbons on ttie tartlk's ozone layer; and one low pressure propellant (eg, trichlorofluoro- consumers are concerned about direct effects on methane). Adir and co-workers = recently described the personal health. ~I - pharmacokinetics of fluorocarbon 11 (FC-1 l,.trichloro- Althou h-oa~Q n~ re~~~' rt nd ~@uoromethane) and 12 (FC-12, dichlorodifluoro- hence stable i~he76weR'layt'fs of"lhe~8`trnd~phe"~c, t~ose methane). FC-11 and 12 are . that escape ento the stratosahe - 0 III Du2-78 S.P. 5~°'
Page 710: wrm95d00
-%L Zia (£L6T) 8~i-£~1 (Z)LZ 'uoltD 0 H M £L_**--a_3aii yx VZ Z E S E£OS
Page 711: wrm95d00
I 50335 3217 cJ11lIEn ZOO HoTFS nocvrUNTAMS, x• eo. r 7'lbMXM 197a LES RISQUES TOXIQUES El CAICEROGEJ\ES DU CHLORUE DE VINYLE O ~ 0 0 N~e die~r T f~TRrUADirecteur du Centre Rae he s ico~ljrq hygiEne industrieNe, facultE des sciences pharmaceutiques et biologiques F I.N.R.S. 30, rue Olivier-Noyer 75680 Paris Cedex 14 Note n° 973-80-75 (36) CDU 616-006 de l'Un%vertitP P~~b nocr,. o-
Page 712: wrm95d00
50335 3229 SOLVFhTS--IMALTH IIAZl.RDcI ~-f' ;Q f"t Q! I T _ iT f content of this document is the result of thc: rtt•liberations of the Joint . pAU/t't:G Expert Cc.,mittee on }'ood Additives ahic:h met in Geneva, 24 June - 2 July 19701 PAO Nutrition Mectings Report Series No. 48A x'tlo/l'O:H) ADD/70.3:+ 120-ME - ~ .a+r e ..' d food znd rSgriculture Organization of the United Nations VYorld Hcatth OrQanization 05000.02 55 1 8
Page 713: wrm95d00
S8335 3228 UNITED NATIONS FOOD AND AGRICULTURE C)RGANIZATinN ' WORLD HEALTH ORGANIZATION/ TOBACCO--ADDITIVES--MENTHOL/ f SWEETENERS/ MF.NTHOL--PHARMACOLO-bY/ FLAVORANTS--TOXICITY/ i TOXICOLOGY-ACUTE TO%ICITIES/ CYCLAMATES/SACCHARIN/ FAO Nutrition'i4eetings Report Series No. 44A WHO/Food Add./68.33 Geneva, 21-28 August, 1967 i MENTHOL--TOXICITY SEE MENTHOL--PHARMACOLOGY/ FLAVOR~NG ES$ENCES- SEE1`WVO _ "" 0 o2ss 1 7 Crn~~)
Page 714: wrm95d00
50335 3223 . - ; • . . r - .. . . . ...- ;~ ~. .• n _ ~~;'~ F.SO NutrWm afertings Xgka.t Sarfcs No. 53 WHO Tadriral Report Soies • No. 539 UNITED IATIf}NS FOOD AND AGRIC'ULTURE ORGANIZATION . . ~6:-74 j ~ 4 1119 5" ~ cc~. Sewnteenth Report af the Joint FAO j{YHO Fxpert Committee ea Food Additives (;eaCSS, 25 Jtcae-4 July 1973 FOOD AND AGZTCEJLTURE OACiANIZATlaN OF THE UNITED NATIONS s,e,.oc. 1974 -
Page 715: wrm95d00
_#`JEO Vix",ritla:n-HIa`-inie°RePM-t Sariq - . Ho. 501, 50335 3227 1i8p Fcod Additives Sarics Mo,t le 14 The evaluations contained in this publication were prepared by the Joint FAO/"O (J(l~V Expert Committee on Food Additives• i which met in Ro®e, 16-24 June 197t UNITED NATIONS Pood rmd 1~qrionlturs Orgm-.zizatioa Wor]d Health Organization Rom.s 1972 y. Fifteenth Report of the Joint F'AO/isHO Expert Committee on Food Additives, t7'_d Filth Or,. techn. Rep. Ser., 1972, No, 488; FAO Nutrition lieetinzs Report Saies, 1972, No. 50. +
Page 716: wrm95d00
I 4 50335 3232 . • XX IInGb 77 i t t The evaluations contained in this pubiirltion we •re prepared by the loint FAO/WHO Expert Committee on Food Additivrs which met in Geneva, 14-23_April 1975' FOOD AND 'AI,RICULTURE ORGANIZATION OF TH4(INITED NATIONS ROME 1975 - • •- . iNineteenth Zepurl of the Joint FAO"O Eapert Committee on Food Additives, k'Gf 11,th Orll. trehn ReD. Str., 1975. No. 576: FAO Nutririon Meennss Rtport 5eries, 1975, No. SS. _~ 5~ 0 t1 C~ 2 5-5? 1 .
Page 717: wrm95d00
- 50335 3235 T4BACC0--SWITZFRLAND/ T(BACCO--PFtARMACOLOGY/ x Ce rtho, A./ ,r4ntre suisse d`information toxicologique lo//3Adt ~i500 0 #! 2 9 52 4
Page 718: wrm95d00
S 1 S S? 0 v 0 p~~ ~ ..j 691 0 rt ~ Iy,~.. t ~xv l, zanztnai z~ ~ bil FU3 pooa ',cwoT:.!!ZI F~°y y :;~) ~f Y^~ sttO ~~22, Pi1oci pti, F '... ~,J, t= :~1 ) Tiv~ C+}f~ ~-te1~J. ~ tlr. r 4ai0u•i +~;ut~7 t ~7 1C,"{7T` ` ,..~:.~ -... YwJ ru S'i~~r'T_a ~v~hl _Y .. rwL. -?.T:~C' .;.1.' :_'.-%,T J lz a i d:i.'°„ slc.;vX ~ R~ ` Xyt~ ..aa~ t)l'3 ¢C4:1 'aY~iJ1 :J J ~~~•T \OL ` Sl+3I3I S'IM3 `, S.;gV4IXQj= .~.t -I.T VE EE i f 9ZZE SEEOS
Page 719: wrm95d00
: . . - I Me5 76 AUTOMATED SYSTEt1S FOR S.P. RESEARCfI SUPPORT OVERV I Etl • 50335 3238 BIOLOGICAL.RESEARCH/ COMPUTERS/ BEPARThtENT OF --NEALTN; EDUCAT I-Ott-A1JD-TIECF-ARE *OOD---AND- -DRUG- ADM1 tJ I-STRAT_l OtJ . U.~„MATtOtJAL CENTER FOR JEFFERSON, ARKA"1SAS 0 5 0 0 0 0 2 5 52 7
Page 720: wrm95d00
50335 3225 f i;~.r..-^ ~~. VUCUMENI G.UMI{:UL VA/L-K 6 V .A.Iraff •nd /nd.an/.nwor.rrawwr. f•..d rwen.fh. L ~(~( i•A(/` ~ (fKwf1/ ff...///c.f/M f Iffl•. Mdv ef N .n pnrr•nf.lf pnrr l. t1. L 1l1.[) , 1 ~ t.ty ,.pwrGrw.urc.Cr.vitrfCeq...r•.umw~ orei-rn Technclo;;,r Divi;:ion F . Air Forcc Syst; I:. CorrJr,ar>s U. S. Air c~r_2- s sts.ewr •rr&.c ;.. ofctacwr.nvc ..orca (1ys• •tr.~.rr.ws fwsw.f.. wu.) 1t r~.r••. .• 7 n t •. .vr..oe:af t~7Ur w..r•, wrsdf. rwtr..,. e..r w.a.j L. V. Stmrnova The HFY tOXl_Ti.~/ M({~t t~.a~:i~:al Y;:c~..... t .o:' t . t in sin= lc an~i ch~•c:~ic i: ' 1' t ~ t I i Lr?IrL1.9STFI .xc•.n v C e.aarc.ucn 2..P[~Ow76ECVw... C~allrfrCarrCv UttiCLA:,iI i~I'. lii?li:(~ :Tt acute, !_°r~n2ts.tj AJI:i chronic tC':at.S . t.S. ir he • • ~ `-s !:_ to.::c~t,;, nci tl:rr•:;i~old co1~ ~ntrat_.,n: oi::cnin?~ ..-.r:~ &'.err..ir.^ o..^o. Clinical sy:~p- ~ ~r, .n ncu o~a o :!•.. desr f' :b- i and, i'ir..s i nK ; of ar.a tor..o- ppLholoric.I' ^i: i:,athnizi.stnlog_ca? Investi.^:rtions in anirr:als F:i_lleci by.FTr'P poison'.tig. -trr° p!•ec:enred. Fiat,& =n:.•jcet to chronic poisioing. With iiFP cl:u::ger! servrn n1Yai:r+._ pi)o:,i;hata:e snu cho?- ines tvra::,- net i v ivies ana e~u i nta i gs sbow:~?d ~n i.nc reasc•d F c en- tent in th~• bf,n: :`El,, p2'<<;c;. u: firi on the r:citivty o:' the hya o- Qhyq sO :r~:-:,~ s~, s t~r :~s E~ :1 iy'.'•c: ir r•: Lca t.-t.• and chroni c I,oi s- oninJ:.. T1,_ ^f ?JI'i' a ~- ,..-..
Page 721: wrm95d00
1 50335 3239 - --.._..... _.._~~..._...,. Appraisal Halogenated Fire Extinguis-ing Agents, Proc. Sy;ap. (1972) 136-47 III Du2-73 ' S.P.• . , Travis B. Griffin, James L. Byard and Frederick Coulston " Albany Medical College of Union University Halogenated hydrocarbons are widely used in industry with the fluorinated mcthanes and ethanes having found important uses as - dielec- trics, refrigerants, propellants, organic solvents and fire extinguishers and suppressants. These compounds (termed fluorocarbons since the pro- perties are largely governed by the fluorine moiety) are commanding aa increasing market in consumer products such as food toppings, h air sprays, deodorants, etc., from their use as propellants. Although the interest of this laboratory in fluorocarbons is broadbased, attention has largely - been addressed to the study of candidate fire extinguishers and fire suppressants. The list of compounds investigated incorporates 11 differ- ent halogenated hvdrocarbons, including the anesthetic halothane (Table 1), but most attention has been directed to studies of bromotrifluorocethane (1ialon 1301) --n3 hexa-fluoroethanc (Freon 116). So:ae detailed uttentioa has also been p,iven to 1,1-di.bro:notetratluoroethane (Ii:2lon 14U21), di- d ectafluorocyclobutane (Freon C-318). ~h]~,~o~G fl~p rq~th,r~e ~~ t ) 1~. ,.... _ - ~.- ~! ~
Page 722: wrm95d00
50335 3230 , ANTIOXIDANTS, EMULSIFIERS AND THICKENING AGENTS u,N by the Joint FAOlWHO Expert Committee on Food Additives which met in Geneva, 25•June-4 July 19731 The evaluations contained in this publication were prepared Ref. .- Meek FOOD AND AGRICULTURE ORGANIZATION OF THE UNITED NATIONS ROME 1974 Ref. - Carlson Ref. - 372 FA0 Nutrition Meetings Report Series, No. 5314 INCLUDING ANTICAKING AGENTS ANTIMICROBIALS, 'Seventeenth Report or the Joint FAO/WHO Expert Committee on Food Additives. tYtQ Ktth Ory. tec6n. Rep. Ser.. 1974, No. 53?, fAO Nutrition Meetings Report Series, 1974, No. 53.
Page 723: wrm95d00
Aata pharrnuuol. 1950, G, 2i19-31 R. _ From ib& DuportmorV of Industru.l Nyqicno, State I,nstit.ate of Public Ilteaith, Turntuboda, Swtxlon. (P'cof. Svun Forasmun hI. D.). ,>AL-Ar-A 1. Toxicity of Fonnstldchydc, Aces.aJdcbydc, Propional(leL; and Itut3•rnidchyda; as wcll as of Acru}ein and (:rntoualdr.Jiy EY Erik Skog. (Received Junw 17th, 18t.0). i IN j os4Z~ooo2 The literature contains few relx)rts on the toxicity of al hydes. Lvwlx (1899) mado test9 by Subcut.wcoux arlministrnt to rabbits and guinea pigs and found the letltal dose uf ucrcl to Ixa 0.15 to 2 g lwr kg of ixrdy woight. 1 ic uscd, however, o three rabbits and two guinea pigs. A pronounced dy,)tttocti Klight anao>sthetie effect and raideniu); of the 1x-riphrral p, 5 5 2 5 .
Page 724: wrm95d00
50335 3231 , FOOD---FLAVOmh,-TS--TOXICITY/FOOD--ENZYMES / FOOD--ADDITIVV,S--4'OXICOLOGY/FOOD--COLORS--TOXICOLOGY/ .+ World Health Organization Technical Report Ser., 1974, No.557 WHO araod Additives Series, 1974, No. 6 r,,, ~, D Nutrition Meetings Report Series l97~. •'~G - .. .. .. .. ~ C~~if1L7J~.t = i I+r~.. . t.~ ' S . ~~''~t•I s.... t-+ The evaluations contained in this publication were prepared by the Joint FAO/WflO Expert Committee on Food Additives which met in Rome, 4-13 June 1974' FOOD AND AGRICULTURE ORGANIZATIO THEUNiTLD NATI ROME 1975 J 4wenem~Nt -Report ot the loint FAO!N'HO Fxpcrt Committee on Food Additir•cs. LW !lIM Org. techn. Rep. Ser., 1974, No. 537; FOO Nutritioa btertcuas Rrport Srrres, q t9 7~ , o. 04. 0 20 Q 5 0
Page 725: wrm95d00
S_lCARCIM06ENICITY . : ,... 6PA-55011-00-001 --- -~ •T/TLE wEPORTpA7E Scientific 40tionale for the Selection of Toxicity '~ubl_#ca_tion datc~Decrwber }~ Testing ifethodst. llwsp .i/esltb Asuess~sent _._. - .-P, ..wsoR..w.avwawwsz..w..cooE c= ~ ' ) A..np:l+- --- -T ~.''ERiORMfMGOR~'iAta7AT10MRErORTNO. il. lt. Ross. M. G. Ryon, 1+l. 1t. Daugberty, J. S. Drury, ) KRFOKWRCG: ONC,AN12AT/0N Nl~tf ~f~7~DDrtl~ 10. rM06~tAY l l~ . N NL. J. T. Ens:.aeg.: r, and M. v. - Cone Health and tnvirormental Studies PrvRta.l Oak Ridge Xational Laboratory P.O. 8ox x Oaic ftidge, TetuttssRe 31530 -;,.___. _ . . . . _ :i. sroMSO+u • aCENCv rrw,uu ~kc ~A r•i1Ss Office af Pesticides and Toxic SubstaaCes U.S. Enviroeoweatal Protection Agsngy _;~..- 4DlRtSt. i1.' iiasfiingtoa, D.C. 20460 l , .__- thl~t~+ijcumestt i1: #:hr +f#;Rt +if "'Ri tuo-,N*t literatarc aua!vsjs of paraw-tt•rs zlasvciateck arith t}~ various utxici~p ttt~ttafi wethods {trst anMal ecelertion, patl,oloRy re9lirevrents, etc.j` Arute, ~tl~cirr~ifc,`rhrcxt3r, ai~d.tsEr.•inovtnic testit~s: m~t11.+J~ :Irr covered; a ali.mssiasn 6t some is,a3sic experriwisetat cl+natrlcratic+ns: Js alu•1 included. 3abies. report vsis prepared fstz i tr~ sist3a:. and w+~pir+rtin~; ti~e 1'.S. l:n:irc :- ~t~i`~~~R~cy~ ~s ff ta oTilcveiep cuidclines for aore rfficicnt and ,_ - aconU ic8 tetbtin~ ptac ures. ~ ~
Page 726: wrm95d00
50335 3245 T ~~ 55 Am American Industrial Hygiene Associat+an HYGIENIC GUIDE SERIES 1967 Detroit _._...~._.,_.~.,.,.,~..-~. .~-.~.~.~ S1 4
Page 727: wrm95d00
RA 1230 Ae 1973 /FREONS--TOXICITY/ FLUOROCARBONS/ COAL TAR/ TOXICITY/ /CANCER--CAUSATION/ CARBON MONOXIDE/ MACROPHAGES/ /HYDRAZINE DERIVATIVES/ AIR-POLLUTION/ CANCER--AIR POLLUTION/ PROCEEDINGS OF THE FOURTH ANNUAL CONFERENCE ON NVIRONMENTAL ~ HELD AT FAIRBORN,~OHIO .0 16, 17; AND 18 OCTOBER 1973 F AEROSPACE MEDICAL RESEARCH LABORATORY Nationai Technical lnformation Service U. S. DEPARTMEWT OF COi.IMERCE i 0 5-0 00 0 25532 `
Page 728: wrm95d00
(0£61) S:Iin`58z `:, '~~ .:-113 'AI;R*=v c07nnor~T=a3tiI s~~~pup.20 aut-np- 4 pnp, UOt TO POA3'Z'`J ' ulddTr ;Tit~ Ppleri3 Sq ` f esncA au3 c;; Slii: ~DS "I 7= 3;I3T"'..",~OVi'i SQ 1~.' 0 .19ft0'fj oip FAW .2
Page 729: wrm95d00
50335 32;8 Annual revxecr of phar2aco2.ogy. v. 1- 1961- Palo Alto, Calif., Annual Rsviavs v. illus. 23 cm. 0500 n025S3 7
Page 730: wrm95d00
50335 3251 79 II Be Beckman Instruments, Inc. TOXSYS INTEGRATED LABORATORY ?NFORMATION SYSTEPf FOR '~ SEARCH Bulletin No: 8700 Oct.,1979 z
Page 731: wrm95d00
9• z s Sz Q o 0 0 5 0 °9T~+j',5Z9 199gG'r"j;`5 ~EaG~a*!t ` i-ZIs"1 "I sdd ~ 71 ao fi7G5-c iCZ^:,t'TiI 47Tu „o ua~~~a:3~~cce;q f.:-;~ .~',o'Eoa=ri-arU xsaTMOtrO 30 i : i ` kmZo;~ ~nz~ .zn~ 42R".4;oM p- t a;~?c,Ic.T~-Jo•J 4.Ix.raF.~'e~D auz:Z4 rrv~~o^~ety; f C, --Tu3_va;.Y u~~rxra4 9u~_,Qr~ raaz;,~ ~;o szT;.zaeo~ f£ZE SEEOS
Page 732: wrm95d00
CHE1tISTRY, ANALYTIC/WATER-ASTM STANDARDS/CHEMISTRY, INORGANIC-= WATER--ANALYSIS/ASBESTOS/SULFUR COMPOUNDS/MERCURY/METALS--ANALYSIS/ZINC/CAD~1IiTi/ 0 SULFATES---ANALYSIS/TRACE ELEMENTS--ANALYSIS/FLUORIDE/ELECTRON MICROSCOPY/OIL SPILLS/ r NITROGEN-- ®ETERMINATION/PESTICIDES--DETERMINATION/PESTICIDES--RESIDUES/~~ rn ORgANOPHOSPHORUS COMPOUNDS/ORGANOCIILORINE COMPOUNDS/POLYCHLORINATED BIPIiENYLS/ ~ CHROMATOGRAPHIC ANALYSIS/HYDROCARBONS, POLYCYCLIC--DETERMINATION/ '~ - 8~ WATER QUAL~ITY PARAM ETERS ~ Am A symposium cosponsored ASTM SPECIAL TECHNICAL PUBLICATION 573 1975 by the Canada Centre for Silvio Barabas, general chairman ZC• lniand Waters and the Analytical Chemistry Division List price $29.50 04-573000-16 of the Chemical I ti ns tute of Canada Burlington, Ontario, Canada, 19-21 November 1973 ~ A/kkERtCAN SOCIETY FOR TESTING AND MATERIALS I ` 1916 Race Street, Philadelphia, Pa. 19103 ~ R - ~~~~~ ` 0 5 0 00 02 5 5 3 5 •
Page 733: wrm95d00
I i 50335 32+t0 i API TOXICOLOGICAL REVIEW, 1948, 1-4(Mar. 1948 Review prepared by Marshall Clinton, M. D. / 2 API '1'oXlCaLOGICAL 1t13VItiWS American Petroleum Instit- Torlt ,:• Dept. a ety, ew s •1rv 1RON CARBONYL - 1. Substanco lron carbonyl. Formulas: Fe(CO)3 iron pentacarbonyI; molecular weight = 195.84. Fes(CO),-diferrononacarbonyl; molecular a'eight= 363.68. Fe(CO),-iron teracarbonyl; molecular weight =167.84. Iron tetracarbonyl is insoluble in water, but is soluble in most organic solvents, giving green solu- tions. In the presence of light, the solutions lose color and iron is - deposited. The tetracarbonyl de- composes to form iron and carbon monoxide upon heating to 140 to 150 deg C (284 to 302 deg F). The iron carbonyls are formed by the action of • carbon monoxide on iron. They may be produced in quantity by the passage of carbon monoxide over . 054AQ42 2'9
Page 734: wrm95d00
ZZ I : 5 5z 40 4 a 5~ 0 d`14T "ituo-d 0161 'a,~ s~iaas ('m .nz?..•. n+.9 + . ..........v .... ...+.a+ w.ar '~+~.....vr ..a...ca• '- ~.._~!x Z:4. _. , ~Iff L ...-j 0 1?i1NV
Page 735: wrm95d00
50335 324? ..~.-,;~...__..,.r' r /. SOLVENTS--SAF_ET'f Hh'ARDS/RADIArION, IOi~tILINq/TERATOGENS/ """"''~~lE~~---TiIXICOLOCY/AIR--POLLJTIOIv'--HEA.F.TH EFFECT/ CANCER--CAUSATION BY CHEl3ICALS/PESTICIDES--TOXICOLOGY/ SMOKING AND HEALTH/TJBACCO--SMOKING--HF.ALTH EFFECT/ POISONS--TOXICOLOGY/ PLASTICS--TOXICOLOGYI E3/acx1!/ +Tlze Basic Science of Poisons T 55 Ca 1915 University of llawaii School of hicdicine, lionolulu, laiw.aa IL Macmillan Publishing Co., Inc XeN, York Laic Professor of Pharmacolo£y. Collier Macmillan Canada, Ltd. EDITED BY Louis J. Casarett, Ph.D. John Doull, M.D., Ph.D. TOTo1fo Baillicre Tindall London Professor of Pharnmcnlogy and Tr.ico)orti', UAni,vorzit2 of 1:sn.as Sshoof of i.1cdicine, © 5 0 0 0 0.4 ,,,,,,,~,.Sa.'< <i(O~F:R*
Page 736: wrm95d00
50335 3244 ~INDUSTRIAL TOXICOLOGY/SAFETY MEASURES/TERATOLOGY/ ~ BEHAVIORAL TESTING/AMES TYPE TESTING/ RA American Chemical Society 1981 copyright 1195 APPROACHES TO SOLVING INDUSTRIAL TOXICOLOGY PROBLEMS Am 8 cassette tapes: AWt TUT5 TO DEF.INE THE PRtN3LEM .: iISI1+N; SUBACUTE TESTS TO EVALUATE SAFETY ~ ~IPPLMTIV6 TOXICITY QATA TO WORKPLACE PROBLEMS 3, ~.,';MA+U4GI1iG TOXICOLOGY INFOitMATIpi ~ . ,.:; S. ASPEOTS OF CANCER TESTING _,A5PECTS OF itEPRODUCTION, TERATOLOCY A!U) BEHAVIORAL TESTING EMEf~IN6 AREAS IN TOXICOLOGY. . "`
Page 737: wrm95d00
TORACC(1--SMOKE--HF.AT.TH F.FFFCT/ TOBACCO--SMnKE--CILIARY EFFECT/SMOKTNG & HEAT.TH'ftORACCO--SiJBSTITUTES/ INHALATION/~~(4TERATOLOGY/CARCINOGENICITY/ RA 1195 Ba 1977 Current Approaches l~ inToxicooy Edited by B RYAN BALLANTYN E BSc, MD, PhD, MRCPath, FlBiol Senior Medical Officer (Research), Ministry of Defence JOHN WRIGHT Et SONS LIMITED BRISTOL 1977 ~5 0 0 6-0 2 5 53 9 - 4
Page 738: wrm95d00
v o2ssz oo©©s s ~ (656T acQim-9qOS) VL"LyCV (G eC i f UT tt ±-L-9ltly JC-~'~.h• 4H t'7jOLiSI 4= •Q0143N "J:' *Ll'.'~371~j0.~ 'et3:qsna ed *YI s"t V0`s3,fiiQUr 11~~ (dls,C"iS) S.LVF--,mFd 'T~iIZL~c~lttUiG~ZtZ -us,ma4-o`o jo saicaLs rrorconooims IVZE SFFtiS
Page 739: wrm95d00
50335 3249 + - . ( RALLQCINOGEiIS/SMdKI1JG AND BEALTEi/TOBACCO--SMDRING --HEALTH EFFECT? i, PRF*Ku1QCY /. - --- - A .Alf'I'IMICROBIAL DRUGS /BIRTB DEPECTS/ SMES EDITOR lVlonographs on Drugs Vo12 Giaeme S Avery, Auckland -D .rug Eff~~~ Av 1975 0! f`1 !e ~~ ~~~US Laboatoire d'Embryoiope, Fac~ute dc Meaeciae ae Paris et sidogiste eas xopatsnx ~e Puis - c~et ae ser;oe r ~ A Survey of the Mechanisms and Effects of Drugs orrrEmbryogenesis and Fetogenesis ISSN OA599827-44 (ADIS Press) ISBN Q88416-121-8 (Publishina Scicnces GroW) ~ ADIS Press, Sydney 1975 Publishing Sciences Group Inc, Acton 1975 t~5©AeQ25s3$ 8
Page 740: wrm95d00
/POLYCEILORINATED BIPHENYLS/ CANCER--CAUSATION--CAEMICAL ASPECTS/ /MUTAGENS/ TERATOGENS/ INSECT CONTROL/ AIR-POLLUTION/ WATER--POLLUTI0:1/ NEW METHODS VT jNf' I.fLL.ON1FIENTA.11.1 C.cft13_.i.11V1i..litsJTRY AND Collection oj-papers presented at the RESEARCH CONFERENCE ON NEW METHODOLOGY IN,&COLOGICAL CHEN;ISTRY Susono, Japan, Novembcr 23, 24, and 25, 1973 International Academic Printing Co., Ltd. 270, Totsuka 3 chome, Shinjuku-ku, Tokyo Sole Sales Agent : Academic Scientific Book Inc. 39-6, Hongo 2 chome, Bunkyo-ku. Tokyo 050 0002 554 -7
Page 741: wrm95d00
I i 50335 3242 C. R. Acad. Sc. Paris, t. 285 (3 octobre 1977) VI Re„-7$ S.P. i , t - 1 Serie D - 829-Q ;~ ote (*) de Picrre Bourbon, Guy Bompari ct Pierre Levy, presentr:e par M. Rene Truhaut. TOXIOOj,orY, STUDY IN VITRO OF T'RE ACTION '1 NITItOGEIQ OXIDE IN REGULATING DISSOCIATION OF OXYHSMOGLOBIN. Dans tcs conditions de nos essais. 1'oxydc azotiquc modific le pouvoir oxyphoriquc du sang, sans variation significativc de la P 50, par la formation dc mkhemoglobinc ct dc nitrosomethcmogtobinc. In the condititnu of our ossrt:o. Nitric Oxide rbanqes tlemoginbin Oxygen Combining Posver (OCP), without any significant wwYe+rrrof P 50. by formation of Aletheninglobin and nitroson+ell+cmoglobin. (/QtIG~TiOJ.J Dans une Precedente Note nous avions mentionnc que 1e NO dim•tnuait in vitro 1'aflinite de t'hcmoglobine pour 1'oxygcne dans les conditions experimentales dccrites : mesure de PO= de melang4s en proportion variables de sang desoxygcne, d'une part, dc sang normai ou de sang soumis a 1'action de NO, d'autre part. Parmi Ics hypothesc:s pouvant expliquer cc fait, la formation de methemoglobine et de nitrosomctltetno&obirle t•*st a-envis{sger. C'est Ic propos de la presente Note. Dc plus, nous ; avoprs Mat* qucj'enregistrement continu de la POz au cours de t'oxygenation progressive d'echantillons dt: sang tcmoin desoxygene, ct de sang traitc dans les conditions dccritcs M ca-apres par le NO, pertnettrait de micux suivre le phenoniene. C'est la raison pour taquellc ~6 uoujjor&es2dr$es rla 3c4cte proposee par Luici Ro,,*,_c'--_. . itli nt comme agent d'n.,r.~ .,' _
Page 742: wrm95d00
50335 3252 .~. -~ POLY CHT.ORINATEn BIPHENYLS/POLYCHLbRINATED TERPHENYLS/AFLATOXINS/ PESTICIDES--TOXI,COLOGY/ III Me9-74 S.P. - 0 3 r BULLETIN OF E4VIRON?ICNTAL CONTA2IINATION AND (No.2) Augusv`1973 Springer-Verlag New York, N. Y. , Table of Contents - A NOTE ON SERUM. p.p'DDE AND p.p'DDT RESIDUES IN PERSONS TAKING SUSTAINED ORAL DOSES OF VITAMIN B- -. - by M. Watson, B. Pharaoh, J. Gabica, and W. W. Benson ............................. 65 OXIDATION OF POLYCHLORINATED BIPHENYLS BY ACHROMOBACTErR pCB by M.Ahmed and D.S.Focht .................................................... 70 RESIDUES OF MIREX IN CHANNEL CATFISH AND OTHER AQUATIC ORGANISMS by H. l. Cotlins, J. R. Davis, and G. P. Markin ........... . . . ... . . . . . . . . . . . . .. . . . . . . . 73 ~ :. . • .. HYDROLYSIS OF EXPLOSIVES IN SEA WATER e. by J. C. Hoffsommer and J. M. Rosen. . . .. ........................................ .78 DETERMINATION OF eOLYCHLORINATED BIPHENYL (PCB's) RESIDUES IN GRADES OF PULP, PAPER AND PAPERBOARD ' - " by S. I. Shah~d R. P. St~noick. 0_E.~Mclnturft~and E. Missh' ~!. f; ~J5©t3©4~2 5541
Page 743: wrm95d00
~ qL ; 55 1 Ga 50335 3260 Garuer, fieuben John VE2'L:RI:wARY TCXICOLCCY, 3rd ed. revierd by E. G. C. C2.ark.e and 1967 477 Fa&eR Wi11iams & Wi1kius Co. Baltia:nze., Md, ~ ~....b,.,w- 050.00 4_25549 i
Page 744: wrm95d00
I I BA 576 Na 1971 , 50335 3259 /SOLAR RADIATIOR/ CLIMATE/ ODORS--AIR P4LLUTI6N/ AIR POLLUTION: AIR QUALITY CRITERIA FOR PA,R'I'ICl1LA Tf MATTER 0 NATO C.ta,,rnmittee on the Challenges of M,osiern S o.c i st Y Z110 Bruxehes, Brussels, Bcigium.
Page 745: wrm95d00
,41,?- -PdEX k Tia~l+-- 4~~CG%A/D0;- ,EA,,l k/wT,~'~ ~'fi,t~G7~a~iDD - - ~ 0~7'•l.y~,~it/yT.s~~~t ~C .v T~d y _ . hY~rot ly m ~,~~Ge~R ~ • ~AKS~Tr~~Y Qy ~rt~E~-~a~1.C --ote,a-~v~y j~A~~tk,N -~~~!-tT~ Bs~t ~ ret/ ~~D ~ ~t -~4~Y~ t y r40,l rs- 3 -) 0: --A I 9 ?/ Cadmium in the r• . EnVironment 0 5 0 0 0 0 2 gAl& F4IBGRG, M.D. MAGNUS PISCATOR. M.D.
Page 746: wrm95d00
T 55 Fr 197z ~vironment ~ An Ppidemiological and Toxicological Appraisal +~ ~ ~alton: [ ars Fntxrg. M.D. Iaroslav Yostal, M.D., Pfe.D. De~rtment of Environmental Hygiene Department of Pharmacology and Toxicology The Karolinska Inuitute and the School of bfedjcine and Drntistry National Environment Protection Board University of Rochester lhdm Swsden . Rachester, N'ew York S , toa G=' AIR--Pt7i,LUTIOA!--;•:L`T'~Ci3RYI CATISA'"TOh'/ POLLTJ'I'7^vN--WaTrR/ T'U.T~LLTTttitd--WsfiiCR/ c.r.yTE~--rOLL?~il(::j EAP/IROPMEI1TAL tEALTH/ FOOYt--- COt1T wiIN4i~'°S/ AIR-~r~Nkb1~SIS~ ~~,:; - 1"SSERCIRY AND DFRIVATT-V$S/:-.: r, :: MERCUXY--ANALS3IS;/- C. 1 I eve-1.11- - , -~ MERCIIRY--METABtJL in t.jj..~jje t ...°•~1pL3[~4~'s .t.c CREMICAL RVHSIErR co. 11201 tkrner.t hutmY • Gn.Wf, ttM 44124 0 50 0 0 -© 2 5 5 4 6
Page 747: wrm95d00
, 50335 3255 .j =.~ .. . _ - --..__...a ~..:; . : . .~.~-t .r : ,.. .. 73 XDe RTR CLASS NO. FA.*4i HLET 73 X 1>~ Dontens:ill, ~'. (f=e.r:nan Ci.^,3rerte Industry P,es. Irst., Ha-~burg, Ger. ) PGLOGICAI. ANATOMY AND PAiii()GE":SIS OF THE EFFECT OF TOBACCO *(Patho2ogi.sche Anaro:nie ur,d PathoCenese der t,'irl:un ; vo n P.eutFcl:e:- Kongress fur arzrli.che Forthildung, 22nd, 15 p., Berlin, Ccr., (Jitne 12-17;~ 1973) (ir. Gerr,an with Enolish Summary) *1973, No. 14, W 5750* *lm* Tobacco ^edicinQ: 0 5 0 0 0 02 S 5 4 4
Page 748: wrm95d00
8e 50335 3254 a~/ eR CHEMOTRERAPEUTIC RESEARCH/CA'.VCER--TREATMENf/DRUCS--RESEARCit/ f~ 7~ PHARMACOLOCY --T0XIC0L0CY / s1e1-waRAPKie OATA 1. Report No. _. 3. ReNf~~S%PS-~le~%0567 SHEET - 91- t D S a e , port I Subtitle 4. Title and I ul y~97 ~Antineoplastic Agents t . . . , : , ., ~ (A Bibliography with Abstracts) ., Performin Or ani d ~ zation Repc. a , f. 1 Ot': . No. Pernell W. Crockett k ~+ k i N / or Un o. t •..Pertormina Oraanization Name and Addreas RErRppuCEO sr ~0• Project/Tas w National Technical Information Service NATIONAL TECHNICAL I 5285 Port Royal Road INFORMATION SERVICE onuact/Grant No. Springfield, Yirginia 22161 tl-S.SMtMCi1[lp yhC~MMERCk Supersedes NTIS/PS-7-5/509 and COM-74-10105 ii, Abataeca 1964_:Tuly, 1976 The citations cover research on the pharmacology and toxicology of antineo- plastic agents. (This updated bibliography contains 209 abstracts, 14 of which are new entries to the previous edition. ) .... -, ,~., _,1 - ~.-. X+ -J _ Y1$, Type of Report a Period Covered r
Page 749: wrm95d00
ry , -71,y _ ~ A Subsidia of Harcourt f3race Jovanoviclt f'ttblishers , ~1 5 0J0 0 0 2 5 5 4:.2, f ' 50335 3253 CARBON MONOXIDE/DDT/POLYVINYL CHLORIDE/METHYLENE CHLORIDE/ IOCCZ3PATIONAL DISEASES~~IOI.SE/RADIATION/INDUSTRIAL HYGIENE/ Ei~iVIRONMENTAL SCIENCES.""AnT~r isciplinary Mono raph Series/ ~. ~. , " LUN --C CER EI+1VJR0 NTAL CAUSES j ~ .~n ustrZa 1230 19~5 Environmental Health © V THE WORKER AND THE COMMUNITY Second Edition Sponsored by Industrial Health Foundation. Inc. Ptttsburgh, Pennsylvania EDITED BY Departmatt of Health and Em~iro~:ment Aluminum Company of Ai~ierica Pittsburgh, Penrrs~•lvanla ACADEMtC PRESS N k S i Y F L i 9 ew or a» ranc sco om on 1 75 , f ! LESTER V CRALLEY AND PATRICK R. ATKINS cL ~a :~i
Page 750: wrm95d00
50335 3263 ~. - ` - . T-• ~~ - _ -- -- - Cray, Chsrits Horaca (ed.) LABORAT= btAKDB0E1lC OF TOXIC AGEii?S. 1966 190 pages l: Royal Iswtstute of Chemistry L.~::-;~:; _~ 45t1tf OQ2 5552
Page 751: wrm95d00
Goodman, Louis Sanford, 1906- The pharmacological basis of therapeutics; a textbook of pharmacology, toiicolo;y, and theraPeutics for phSsicians and medical students, by Louis S. Goodman and Alfred Gil- man. 2d ed. New York, biacmillan,1955. xtii, 1831 p. diagrs. 26 cm. Includes bibliographies. 1. Pharmacology. 2. Toxicologs. 3. Z'herapeutics. L Gilman, Alfred Zack, 1J03- joint author. n. Title. PINi101.GG3 1955 0 615 55-1103 Librar}- of Congress 158j=51 o 5 0.0 0 0 2 5 9 5 1
Page 752: wrm95d00
lAOOERN ANALYTICAL CHEMISTRY 50335 3264 Sersts 6d.ta•- Darid Harcuks (ln..vrs•tr 0/ /ftZOvly// ~. DISEASE/MfOCARDIAL I11FA1tGTION/PATPERN RECpGNITIQg/ CLINICAL CHEMISTRT/CREMISTR7, CLINICAL/ --ANALYTICAL METEIODS/flEABT-DISEASES--DiAGNOSIS/ NETALS ANAL?SIS(Pricious)_/ PE?*OLEIM INDDS?RY ANALYTICAL APPLICATIOiiS OF ATOMIC SPECTROSCO!'Fj ANTPa~vrlvN/ ~, . . 454 Appne ar ,.e rSpecfr ! tomic scopy Volunie 2 Ed'rtedby E. L. GroVe ~!~ ~ 0 0 2 Sj'l%WW Prew • New York and London
Page 753: wrm95d00
50335 3272 Huntor, Dor.a2d, 1898- The disesses of occupations. jkth ed.j Bostoa, Little, Brovu (19b9] xac, 1259 p. illus.,ports. 23 cm. ;05t3.000~5Sf~ !
Page 754: wrm95d00
~~ss~oaooso 'FIL, 'd:tcsnT4IQg 'o5 "rnT_'.t 9 sui» T ,, Ra~isd it s~~o 1 • z jT,.TiI orl,T ~F C SSI PIoawT2 C•34nod H t's a~jasso o '3 1+3Cv • -+ i, noT38~ ny `(;n7IYd 4.~'srG;?i ~~tj;;~:~s!~d ~;,2^.y SS
Page 755: wrm95d00
_ 50335 3270 x HiA2 itilding, A. C. (St. Luke's Hospital, Research Lab., Duluth, Minn$aa!:a) NASAL H'3COSA AS A TEST AREA FGR 'ri.:E TC:XICIT: OF CIGAr.LTI'F SMOKE. Arch. Otolarpngol. 82 (No. 4) 425-26 (Oct.1965' ~ 0 s 0 0 ~(} 2 5 5-.5 9
Page 756: wrm95d00
50335 3269 ~ LcBRY0CENESIS1FTrUSIJ..ONSW/TE1tATOGENS/SIfDlCING AND HEALTfi/ TOBACCO--SHORINCr-liEALY11 HFFF.CT/ OLLI P. HEINONEN, M.D., M.Sc. DENNIS SLONE, M.D. SAMUEL SHAPIRO, F.R.C.P. &W Ep/deRllOlpQr Unit Boston Universiry Medical C.nter , 0 500 0 o z 5ZS8 RK 300 . Re 1977 ---I_ - _ _ BIRTH DEFECTS LN4REGNANCY ~&NDv6RUGS _ mitk_ . :L I
Page 757: wrm95d00
50335 3273 ~ -XTI :jfe ~ -76 q Codference on CUICCAL TO)UCOLOGY 8(3), pp. 289-304 (1975) ~ piclemiotogy-HLaltn Effects of Pesticides* A Review of the Problem KINGSLEY KAY, M.A., Ph.D. Mount Sinai School of Medicine NeT York, New York - ,,/ ,rr,Q~ ..."I - The current year. has been maxked by an unprecedented number of important developments related to pesticides. The following six 1974 pesticide-related developments are dealt with and discussed fn relation to to.-dcolo.ay, epidemiology and health effects. O O 2`~.eM~la'~! 1~1c,Fide~a~~January y, o f~ c c ens under OSIiA-Februar @ Ranninrr nj, zl.drin and dieldrin-August -i
Page 758: wrm95d00
/POISON CONTROL CENTER/ NICOTINE--METABOLISM/ LUNG DAMAGE/ /PLASTICS- TOXICOLOGY/ ELASTOMERS/ POLYMERS AND PLOYMERIZATION;'/ RA 1235 fla 1975i~9% ESSAYS I N IUML yolu([ie 6 ) Lj,rl 1975 Edited by WA YLA ND J. HA YES, f R. caIfTER iN TOXIODIAOY DtTAR7NEMT Of HIOCNEMiSitY S~HOOL OF MEDI©NE VANDERJ[LT UNIVF.RSflY 1[Af![VI1.LE, TENH[PSEEE A C A D E M I C P R E S S New York San Francisco London A it7StiC7A[Y O! HA1tO0URT SRA(S )OVANOVtCii, PUBLISltEBS
Page 759: wrm95d00
50335 3268 , ~ ._ ',e, 7S t P. ,..r.~:.._. IBLIOGRAPHY ON THE~ NVIOP VINYL w * CHLORIDE AND POLftNYt CHLORID EP-ft" ~ Harry Heimann and Ruth Lilis .; -~ 1~¢unt SF~~Scl o! of ~cirle ~~CflYlUni~ •rsiry ol NcY YQr w Yorl,1 Nt w nrk 10029 " We .-_____. 1 ~Donald T. Hawkins Because of the widespread interest in the subject or vinyl chloridc and poly- vinyl chloride, it was deemed useful to gather together the available bibliographic material in order to provide a background for current research and evaluation. Three surveys of the literature were made for this purpose, one by the National Institute for Occupational Safety and Health, another by the Bell Laboratories, and the lasfb~ the Environmental Sciences Laboratory of the Mount Sinai School of Medicine of the City University of New York. Since the three were ap- --{.-A f.- .n.......f.e~ rti(}'ornnt snrenPrtivpc -wnri PACh CnntlinCd Snirie refer- Bell Laboratories 1 M_urray Hill, New Jersey 07974 (. 0 5 0 0 0 0 2 5 5 5 7
Page 760: wrm95d00
50335 3275 I Iiir:: vl, I~. J. :'C}}:iCITY STUDIES. Jou,:. Suc. Cosa:eLic C'c:e..^isf:s 15, 395-409 (ISSw) o5 oo0- 0 2 5 s6a
Page 761: wrm95d00
Roasrcr A. KEHOE ZJdaersity of CGncuuutJ Medicol Centa. Kettering LaboAotory. 3223 Eden Acmwe, GTReLMatl4 Ohio 45267. LlSi1 1. nN'rROnUMox Any historical account of the earliest recognition by man of the existence of lead as a natural resource as well as a material possessed of potentially harmful qualities. would be redundant, repctitious, and, in all probability, inaccurate. It suffices here to say that the antiquity of various types of information about this metal have been remarked upon by many previous writers, and that the metal and certain of its preparations were being used for a variety Qf .pP4rpQses,.in all likelihood, before historical time. As the experience and inventiveness of man progressed, and as his knowledge of minerals increasecf. ` he found this metal to be procurable with relative ease through the application of heat to stones of a certain character and source, as well as remarkably ~ ; ,, , ~ _ .~,~r•._. - 0-5 .0.0 0 02 5 5 b 3
Page 762: wrm95d00
~r T~~ ; ~ ALKALOIDS }l~Td Chemist~y and I'hysioIo~ T b3 Edikd by R. H. r. MANSKE UttiRoyal Limited Itc-neh Laboratory 0 Oitdpli, O'etario, Canada ;
Page 763: wrm95d00
TOBACC4~THEALTHGEI~~FF.CT~fiADI~ACTIVE SUBSTANCF.S--3"7._ICOLO(,Y/ FORKMEN'$ COMPENSATIOt:/ OCCUI'ATIONhIr 7SIt'~'.A.SEE/CAMt2'IStitMAt~B'ON MONOXIDE/SELENIUM/ HYDROCARBOHS--TOXICOLot."T/ DUSTS--INDUSTRIAL AND ENVIRONMENTAL ASPECTS/ENVIRONMENTAL HEALTH/AROMATIC RYDROCARBG%" TOXICOLOGY/LUNGS--DISEASES/DISEASES, OCCUPATIONAL/ARSENIC--TOXICOLOGY/MYCOTOXINS/ PESTICIDES--TOXICOLOGY/CHEMICALS--TOXICOLOGY/METALS/PLASTICS--TOXICOLOGY/ 579~Ha I . J. Nl.J ~..1 ~ T1 \ I,~ L THIRD EDITIQN ; t 197k Alice Hamilton M D t Lt A i t P f F it f I d xd M d e ss s an ro essor sner : o n ustr e icine, Harva:d Sdiool of Public Health, Bostaw, Massachuseqs 1~ i tZl~ "' ' Harriet L Hardy, M.D., F.A.C.P. Cimmid Ptofessor of OccvpaDonal :.fedidne. Depaetment of P:e.enti.e l'tedidne, Harvard Medkal School. Bostact. Massachu:setts PUBLISHING SCIENCES GROUP, INC eft Acton, Massachusetts ~ ~ a wbsidi.ry of CHC C- ..•, . t. i I
Page 764: wrm95d00
~ :.1.21% : _ - ..- ..ra.rr....~_ J0& Ci1EMISTRi, ANALI^TIC--COLLy ,t'TE'O VClW-SiAIR--ANALYSIS/ WATER- TREATMENT/POLLt3TION CONTROL/ ENViRONliENTAI. HEart'H/ ODORS --AlEAS UREMEN'P /WATE R--ANALY S IS / TREATISE ON - ANALYTICAL CHEMISTRY $dited by I. M. KOLTHOFF Dtpartmtrri of CIleraittry, Uieiver•ity o f Alinnaota, jfvuieapolis, Dtinnssota PIiILIP J. ELVI:CG lkpartamnt of CAerniatry, linicrrsity of Miebipau, Ann Arbor, dlidkiyax aad FRED II. STROSS .AJitR Dcvelopneeet Con,gasy gswyvWe, Catiforsia PART III ~ ~TALI'TICAL CHEMISTRY iN _~P,'~?DUSTRY VOLUME 2 SEClION B usttial +wd ERvirmmantal .but:on.a C4ucrol WIl.EY-4\TERSCIINCE 0-5 0 0 0 0 2 5 5 -b 5
Page 765: wrm95d00
50335 3277 k _ INTEANATIONAL OCCUPATIONAL HEALTH CONFERENCE/ OCCUPATIONAL SAFETY AND HEALTS/SOLVENTS--HEALTH HAZARDS/ ~~ CfiEMICALS--TO%ICOIAGY/GENEBALLY REGARDED AS SAFE/ ;A chemical agents in the workplace 445 Le WORK HAVAR ' 1975 ~ ~  ,~ ~~ ~ f h 0 ~~~~~ ~~~ ~' ~~~~ ~. , secretary general 39 ~ in the united states, germany and sweden Z,;R 1 g75 ''"' ,j charles levinson y rG~ ~ ~' . 0 S 0.00 .0 .2 5 5 6 6
Page 766: wrm95d00
>. ~ STEROIDS 8 S" --HE~DLST... ~Shl, v. ]crT _. m5Q,Y.1/ Itl UT TKlt*iE -S--TRANSFERASES IN RESTICIDES---- TOXICOL06YACi6AMDIN & THE 8I_ NDIN6 STEROID lETABOLITES= CARCII~t06ENS i OTHCR COMP(I!!~lDS, Y. ~ ,_~, ,1. AERI1/ATIYES Y. 2 ./ACETANINOPNEN,Y.2/ CH.oWFoFM, v.a . L,z/METTABOLISM-.4IOe&MISTPr,v.i,2/ 1~ REVIEWS #iOCHE~IICAL TOXlCOLOGY, VOL. i( i 979 : ,. . 2 (1980.
Page 767: wrm95d00
I 50335 3287 i ~ , ..i .A T 55 In pe t ~. .y x }'.YGUiZ AhD 7~'~XIG4:~'i. ~ 4- ~~ 2uu rin. ed. ~ i.mt.cr:aaieU;:S Pub1Tshexs !cj York T 4500 0 02 5 S.7 6
Page 768: wrm95d00
50335 3200 MUTAGENESIS/CANCF.R--CAUSATION/CANCER--GENF.TICSfHIGH RISK POPULATICINS?/ ENVIRONMENTAL HEALTH/SMOKING & HEALTH/TOBACCO--SMOKING--HF.ALTH F.FFECT/ CANCE~--CAUSATION BY CHEMICALS RC `/Journal of F,nvirotamental Pathology & ToiricoloEv 1_(2).(*tov.-Uec. 1977,388PP 267 Special issue Jo Proceedings of the Conference on 1977 I- 'f}iE STATUS OF PREDICTIVE TOOLS IN APPLICATION TO SAFETY EVALUATION: 2 C. PRESENT AND FUTURE (Carcinogenesis and Mutagenesis) Guest Editors: Myron A. Mehlman Morris F. Cranmer Raymond E. Shapiro It. APPROACHES TO DETERMINING THE MUTAGENIC PROPERTIES OF CHEMICALS: RISK TO FUTURj(~ ENERATIONS 111. REPORT OF THE SUBCOMMITTEE ONNHALATION TOXICOLOGY OF THE DHEW COMMITTEE TO COORDINATE TOXICOLOGY AND RELATED PROGRAMS . Sponsored by the „2p' NATIONAL CENTER FOR TOXICOLOGlCAL RESEARC J JlH Food and Drug Administration ~ S O O 0 2 5~ Jeffgrsoand rkansas -- IG NATlONbAL INSTITUTES OF HEALTH 0 0
Page 769: wrm95d00
Plunkett, Edmond Robert, 1922- . Handbook of industrial toxicology, by E. R. Plunkett. New York, Chemical Pub. Co.,1qG6. vi i 1, 440 p. 23cm. BlbliograpLc : p. 43'_'-4°_4. 1. Tndustrial toxicology. i. Title. RA1216.P55 ~ ~` ~``'~ 615.902 66-7U71 Library of ConUe=s fRl
Page 770: wrm95d00
S0335 3285 RA 576 Na 19,75 2c. Archer Zc. /POLLUTION--AIR/ AIR--POLLUTI0i1---APiALYSIS/_ /AIR--POLLUTION--HEALTH EFFECTS/ CANCER--CAUSATION BY CFiEMICAL3/ /PHOTOCHEMICAL REACTIaNS/ Principles for Evaluating Chemicals in the Environment A Report of the Committee for the WorL'ng Conferencr-on Princifrles ojPiotocols for Evalrating Chemica/s in thr Enrironmrru InVironmentat Studies Board National Academy of Sciences- National Academy ojEngmeeriny and Comndttrr on Toxicology National Research Council NATIONAL ACADEIAY OF SCIENCES MASNINOTON. D.C. i1TS 0 50 0 0 0 2 5 5 7 4
Page 771: wrm95d00
50335 3281 ` QL ~ 55 ~ Mi l -r Miller, Um. 0., ad. PR()GEEDZ23GS: tY?NFE~~TCE ON N0iv'MLMAPI P°,ZYASE TvXZCO3.0GY, Food and Drug Ac!mf.nistration, ksacrsntaa, ©irginia, JLme 12-14, 1966 14~6 168 Pages W3hingtan, D. C. 0 E} S 0 0 0 0 2 5 5 7 0
Page 772: wrm95d00
/HYDROCAgBONS, CLORINA?ED/WATER-POLLOTION/POLLUTION/ RA 1235 tMC 1975 Ecoue[/ogicalocenx/ Research Effects of Heavy Vetal and rganohalogen Compounds trooe.dimp ot a NATO Science Coma~itoee Conb~eesae EdiLCd by A. D. McIntyre . DWwtrntnt of.4gricultute and F'~sheries jorScoNand .tbeideen. Scotlwd snd G. F. Mills 1Tie Rowvtt Resewck Institute Abadeae. Sc+otlmrd PLENUAI P~ES ~NEW YORK AND LONDON 0~~ue~in ~ at n with NATO Scientific Affairs Division
Page 773: wrm95d00
50335 3283 - Ni11~tj.? . 21-. THE 7"HQajL1.CJ CririliZC)F ~!t i TO?;1C1i y OF T~'iRAC;O 1N G CAP±CZTY OF Qr .~,1.t,ECo't, " A21D VAIi, Ill. "'~L '_e- , . k, . <:_ } ) c R.. Photostat fronr>Ch~r:;ica., milr'.p. ?3 (t1.,,, 35 (1957) - ertd Enplisri t:r 333-ho (1959) - ln italir.n; ln 1i,a1ikrs.
Page 774: wrm95d00
50335 3266 ~~~~ HEl1LTfI _ ..P" . . CADl~IUk[--TOXICITY/ i: a is RA 1231 8a 1978 TECHNICAL REPORT DATA - jM.v+r IwJ /watnn7a,"t ext tlir /•rrrm• kr/.srr tw>rmlrtirgl 1. RtvunT NO. _ SPA-600%1-78-026 . .1. T11LL A~It~SUHf/TLE - _-- Review of the Environmental Effects of Pollutants: 1V. Cadmium Oak Ridge National Laboratory Oak Ridge, Tennessee 37830 1 AttT11URi ;~nna . Hnm~na, Jn~cs ~dwa-~liuf f, tielen M. Braunstein, John S. Drury, Carole R. Shriner, £ric B. L-ewia, Bradford L. _H_h_itfiel_d_,_a_n_d_L_ei~h E. To~rill ~-----_ '!. PtRFURMING UN(iANIZATIQN NAMk AND ADURESS [nfomitiun Center Complex, Information Division i persistence #s~ thc env rotanent; assesssent of present and potentia ea t an , anvitonmentai hazarda.:. _..ai~d ~C~. _ 9 AL. s, - I. PORT OATt June 1978 PERFORMiNG ORGANIZATION COC W PERFORMING ORGANIZATION REP t0. PROGRAM ELENIENT NO. fRA616 AC / ANT N . IAC D-5-0403 39,. TVPE OF REPORT ANO PERIOO CC . I'inal W ~ft3NSORING AGENCY CODE U.S. Environmental Protection Agency . ~ 8PA/600/10 Cincinnati, 'tlbio 45219 report is ~s review of the scientific literature on the biological and environloentsi effects oi cad:,uium.' Iacluded 1n the review are a general summary ahd a comprehe"ive -discussion of the following topics as related to cadmium an( speci,fi:c ca4aiuwt compounds: physYcal and chemical properties; occurrence; ~as ~thsesis and use; analytical sEethod~e+~ logy; biological aspects in microorganisms, i~rteqlt~n~a1~ ~' 11uQla3~s: distr~..btttioil. ~bility, and 1 h l h d 12. iPCMItiORING AOENCr NAME AJ~W AODIIE!! Health Effects Research Laboratory, Cit~-t!H Office of Researth and Development
Page 775: wrm95d00
50335 3286 k xENTEROTOXIN-MEDIATED DISEASES/P'R'COTOXINS/PESTICIDES4 CADAIIUM/FOOD--ADDITIVES--TOXI COT.bGY[FOQJ2_-pOI SONING/ TOXICOLOGY--TRACE SUBSTANCES/ ENV R(1N I "~NTAL HEALTHi RA 1230 Ne 1976 Edited by Paul M. Newberne Massachusetts Institute of Technology Cambridge, Massachusetts MARCEL DEKKER, INC. New York and Basel TRACE SUBSTANCES AND HEALTH
Page 776: wrm95d00
'~'' ~~ "O`l`vw- ~F"O ~Za`-'i`r - - ~• . - C~ ~'/~ . IIAI- 7t% ~ ~ . ../~ c co LAW° ~} f ~ . ~ r_RS, SOURCIJ IiOOK ~ / ~' ! 7Y«• .rtlornc.y's ~,' ~ / o~.~. , infc~rniatiolz• cxpcrts, artJ ccrosr~l:atrr. ; b ~ y I ~ / Rov Mtt-t i:1: { \'OLL',1i!:: 2 ~.~ ' Cj'0 2 5 5 7 1 ~~ rJ < ' 147{
Page 777: wrm95d00
- ~r+...~.._ -aw.,^. 7~R 50335 3289 • Pr2 1967 ~rF PR7C~,?sL'IN JS oP THE CONFERENCE ON ATY-oS?m IC C:}11i.".s.MIIdATZCii IN CQNFIh'EO SPACZS, Ml ZfiUT- PhTTER.SON AIR Ei't~tCE BASE, AEROSPACE MP.BYCP:L DI"r-IS IGN , DkY'FON, OHIO, MARCH 30 - APKi. 1, 1965. Decer~.aber 1965 U. S. D$pt. of Cvmsrce Washington OS0 Q0 0 -~~S .7 0
Page 778: wrm95d00
50335 3290 T08ACC0--SMCO , --~ !a YN(1,~LEAR HYDROCAR80NS/ AIR--POLLUTION--PARTICULATE MATTER/ WATER--POLLUTIONCHEMISTRY, ANALYTIC--ORGANIC/ fNERGY SOURCES 01" PNA/ MUTAGENICITY/CARCIN06ENS/ ENVIRONMENTAL NEALTH/ HYI*OCARBONS POLYCYCLIC /COAL/ POLYCYLIC AROMATIC COlPOUNDS. , ENVIRONMENTAL HEALTH RE1ifE~l 1~6. '5%I-' xROI~ATiC'-C~1RPOi1NDS--TOX ICOLOrY ~~2 HEALTH IMPACTS OF Pu 1981 4OLYNUCLEAR AROMATIC , l o..+i HYDROCARBONS Wh.a by aw. ft*„ac WYES DATA CMPORATiON ftfk Rjr... ww. Aw.w. us.A. ml
Page 779: wrm95d00
RB 40 Si 1974 50335 3296 -- /I10NNOLOC:Y /FOOD--ANALYSIS/ MINES, BIOGENIC/ METMODS IN RADIOIMMZIhTOASSA Y, w D "RELATED AREAS PROGRESS IN ANALYTICAL CHEMISTRY 0 Edited by VOLUME 7 Ivor L. Simmons 1UT CAaaieoL, lee. Raboay, Nen Jsaey and Galen W E«ring &st- BeR U.iressit y SarlAOroxps, New Jenrey PLENUM PRESS • NEW YORK AND LONDON
Page 780: wrm95d00
50335 3298 ~. -=:.~.,......:... ~..r..~.~r Sollmann, Torald Hermann, 1874- A manual of pharmacolony and its applications to thera- pe.utics and toxicology. 8th ed. Philadelphia, Saunders, 1957. 1535 p. 26 cm. 1. Pharmacology. 2. Tozlcotogy. 3. Therapeuttcs. RS187.SG7 1957 615 57-7048 t Library of Congress ~ "" 157n101
Page 781: wrm95d00
50335 3293 Tobacco--Pharmacology/ .~.J Tobacco ---Constituent!~ 73 X Re2 R. J. Reynolds Tobacco Company, Research and Development S.P. Depts., Science Information Division TOXICOLOGY OF TOBACCO CONSTITUENTS. A COLLECTION OF MATERIAL Q 5ro 0 0 'o 2 5-.'a 8 Z
Page 782: wrm95d00
~yp N.t f~Pi:~ 4 ~~/5.4.~+P s~ i~ riaZ's r tic-- DETEI? Mi.ei,~ T riV~ e'LCCTK~~ ~~~Rds Lory ° i°ARTIGLE s•126 /y/iE&t HRE/IJE~VT~PARr i GLES --i97 YliJ ,,C/LtRA'riONIA. ~Qyl s JA•rrel1i~4/WIcRSSC!~~ Particle Size Analysis imreVs4; in Industrial Hygiene t9;'I LESLIE SILVERMAN, 1914-1966 Late Professor of Engineering in Enrironmental Hygiene Harvard University School of Public Health Boston, Massachusetts CHARLES E. BILLINGS President, Billings & Gussman, lnc. Waltham, Massachusetts ! MELVIN W. FIRST Professor of Environmental Health Engineering O . Xaryalyd nir iry hop j of Picblic Health al (~g~j ~S i~i
Page 783: wrm95d00
50335 3292 , r -- -- - - TOBACCO--PIIARM..ACOLOGY. 73 X Re TOBACCO--ADDITIVES--TOXICOLOGY/TOBACCO--FLAVORANTS/FLAVOP.M°TS--TOXICITY/ : 1 HIJMECTAivTS/TOBACCO--IiLTIECTANTS/DIETIIYLENE GLYCOL/ . . . rJR CL1:SS NO. PA.Mfl'RLET 73 X Rel S 1 N F:i U S ' nstor.•- a em. . . . C.. v, Reynolds, It. .3. Tobacco Compan TOXICOLOGY OF TOBACCO ADDITIUS. A COLLECTION OF MATERIAL. ' -"'Re}•nolds, R. J. Tobacco Co., jiillStOn=:Salera, N. C. , variously paged (1973) (in Er.blish) *Keywords:* diethylene glycol, tobacco, additive.
Page 784: wrm95d00
~ 2240 50335 32914 ~SC Schi,eveYbein, Hclaaut NIKOTIid PFfAS.'1?.KQLOGTg tTYD ?QXIKQLOGIE DES TAB14i:RAi3CHES (NicoF,ine, Fbares.acology sad Taacicology of Tabacco Smoke) 1968 333 Fages Georg Th`mss Verlag Stuttgart, Gesmtny
Page 785: wrm95d00
50335 3300 ;T ~ ; 55 i S Stewart, Corbet Page, ed. ~ Tosicologq : mechanisms and analytical methods, edited _~ by C. P. Stewart land] A. Stolman. New York, Aeademic- ~ Press, 1960--61. ; 2 v. illus. 24 cm. i ~ Includes bibliography. 1. Tozicology. r. Stolman, Abraham, 1908- ~ r j RA1211.-S i 3- 0615.9 Library of Congres.ss 4 5 0 4 t~ 0 2 5 S 8 9 jr(llh% joint ed.
Page 786: wrm95d00
TOXIN POISONING/WATER--POLLUTION/ .FOOD--ADDITIYES- XICOLOGY/FOOD--POISONING/ PLANTS, POIS /BACTERIA,PATNOGENIC/MARINE TOXINS/ ~ : Survey of ~ Contemporary ~ Toxicology 0 8 0 4Q02 S593 S0335 3304 ~~~..~ C~cl~ ~
Page 787: wrm95d00
~ . Spector; William S ed. Handbook of toxicology. Prepared under the direetion of the CGo:rinnittee on the Hnndbook of Biological I%ota, 'Divi • sion of Biology and Agricul(ure, the National 1~c:a~lPn~~ of Sciences, the Nationa.l Research Council. Phi!ade.lpiu8, Saunders t~1956 ~ " I v. 28 cm. Includes bibliographical references. CONTE2fT8.-r. 1. Acute toxicities of solids, liquids and gases to laboratorvanimalsy Vol. zi. AT3tibiotics 1. Toxicology. L Title. RA1211.S62 Library of Congress ~ 615.3 t56k10j 0500t14ZS588
Page 788: wrm95d00
3291 TOXIC SUSSTMICES/ArLATOXINS'rANCER--CAUSATION BY AFi.ATOXINS/ ZVVP=~' liTJYiLSSN2 S4 J:.RIDu."ti.lLLl~.~r.L./.La". Rt'~ILj.jsd1-.. SYMPOSIUM ON Edited by . ~ I. F. H. PURCHASE ~ ~N IN HUMAN HEALTH The Proceedings of a,jMposium held in Pretoria from 2nd to 4th September 1970 under the auspices of the~uth African Medical Research Council with collaboration of the South African Council for Scientif c and Industrial Research. r
Page 789: wrm95d00
50335 3301 fV^SbL ':eP. Irvi- `n _ i iiAi:.?I:i,7j: OF ANALYTICAL T(1XICOLt)GY. 19<9 IpRl parw; I The QC .ca, ~~:x. Rubuer CO. Cieve 1tiiiu , 04, k OS00~02SS9D , 1 I
Page 790: wrm95d00
50335 3284 .. . _ ~.:: _ ._ ..- .._. - . ~. ~ ~ . ,~-._.... +s ., ~..- ,n•.y~,ay~: -r-r~4F'Y"t,i~r W- _'"P .. . . ....• ,r - _ `- S tOa+mime on Adehydea Dowd on Toxkolojy md Environ Assea*1Y of Ufe Scienoa~ . ' . . - ~Nat~snat R~ard~ Gaa~cil 0 ; ACADEMY tRE55 I ~ ~'i~~lID.z. tn
Page 791: wrm95d00
i WATER--POLLUTION/AIR--POLLUTION RA Cadmcum Pollution 1231 Sm 1975 • ~ Eihtia -raptly/ with !',bstraett r Mona F. Smith 9. 1' • fn ming Or ani uun Name and Address pe wne.~rt e..~ Nationa~ `Iec~inical Information Service 5285 Port Royal Road Springfield, Virginia 22161 ' Air and water pollution by cadmium are covered in this bibliography, includir-, sources, control techniques, emissions, transport properties, effects ot; plar, animals and humans, and detection and analysis. (Contains 143 abstracLs) Searcb pariod cotrsred 50335 3297 NTIS/PS-75/681 )2, Sponsoring Organization Name and Address 15. Supp)emcntary Notes Supersedes NTIS/PS-75/020 ,
Page 792: wrm95d00
M A Report by the Committee on Environmental Improvement 9 ~ American Chemical Society Washington, D.C. _ _ --, _ Second Edition ~:~
Page 793: wrm95d00
IdS6t000oS O in~, z I it.31t:{\3 Qfi'ye3-r~ a'~'TIl ~1.:I ic ~ ti,t3. . i^ Z-4-1q C°`z; rq "'t.f :CA SQ)l 0 i cid X ?Is{:'s nl~4 c;yl<a.tL ~Z ajMQ"1 °--3334.i-13~ `"9,1 t~~ °A :~a`' aari °,yzc; ,,<.L pZOi"T A.{ jZY`;i 37 Y? I
Page 794: wrm95d00
50335 3306 I1qDiTSTRIAL TOXICOLOGYpOI,LUTION/NOISE--POLLITFION/VINYL CHL4RIDE/ 75 I Ze Zentralinstitut fur Arbeitsmedizin, Hamburg, Germany REPORT OF THE ACTIVITIES OF THEWMAN INSTITUTE OF =PATIONAL MEDICINE (ZENTRALINSTITUT FUR ARBEITSMEDIZIN) IR"HAMBURG. A brief report on the activities of the Institute, its professional personnel, and includes a bibliogranhy. The main areas of interest are lead contents of foods and beverages, industrial problems caused by chronic effects of solvents, industrial noise pollution, standardization of industrial toxicoloaic::l laboratory procedures, long-term effect of hydrogenated hydrocarbons, and vinyl chloride. , In,.iI ~AiI I If tl 1 V . I 'r
Page 795: wrm95d00
zo9sr 0 0 nvsq " i: .:: Z *ToA `3iIl StII+ITaS ;?a.'-.OOTi .2 .13*1,,T,COu EIEE SEEOS I
Page 796: wrm95d00
T 55 Aa 1971 z C. POLLUTION--AIR/ /INHALATIOIt/ tHEMICAL*COHP0UNDS--TO7CICITY/ INDUSTRIAL TOXICOLOGY/ AIR--POLLUTION--COLLECTED WORRS/ -DOEUMENTATION OF THE THRESHOLD LlltiilT VALUES -" - far • Snbstancs , . ~ :. Workroom Air ~-- ABERICAN CONFERENCE OF GOYERNIitEN7AL INDUSTRIAL NYGIENISTS Third Edition 1971 ~ LiBX'/;fp ~ . --.-_. ~.x.,.~ 0 500 o`025'5 94-
Page 797: wrm95d00
u 50335 3307 ENYIRONMENT HEALTH/CAR80N.MONOXIDE/WOMEN rFPSYCHOLOGY, NDUSTRIAL/STRESS/IATROGENIC DISEASES/ PESTICIDES- OXICOLOGY/ RA 7 230 Ze 1980 r, -- .a ey CARL ZENZ, M.D., Sc.D. ConamrM b DhANon d FBob d Wf.carin; Carultft 1D WWkwiml Usfittb 10r OopqstiorW 8d*y an0 liNlRf AooMrIN. M4ryWXL Arodob PrdM= d 0cqqMaml wd - £rnfroMrrft NOi1Ms tMtirrnfly o( Onoli. CWoapO, wM1Y; QoWA01mt tb U.S DepaAmwt o1 l,abor. YU.N~inpWt4 QC.
Page 798: wrm95d00
50335 3314 TOBACCO--SUBSTITUTES/SYNTNETIC PRODUCTS . TOBACCO--SMOKE--CHEMICAL COMPOSITION/TOBACCO--SMO~CE--BIOLOGICAL TESTING/ TOBACCO--St;OKING--ANIMAL EXPERIMENTS/ANIAtALS--TOBACCO--EFFECT/SMOKIhG AND HEALTH/ _ TOBACCO--SMOKE--HEALTH EFFECT/ RJR CLASS NO. PAMII'HLET :{I :;e2-74 s. p. . RI Ne2 74 ~ Celanese Fibers Marketing Company, Charlotte, N. C., L'. S. CHF.HICAL AND BIOLOGICAL PROt ERTIES 0F . CYTREL S:'DKING PRODUCTS. S.P. ~ Celanese Fibers akt. Co., Caarlotte, a`:"C., 28 p. (1974) (in English) - *Keyoords:* carbon dioxide, smoke, constituent; water, smoke, constituent; ' nicotine, smoke, constituent; tar, smoke, constituent; methane, smoke, constituer.t; , ethylene, smoke, ccnstituent; :- acetylene, smoke, constituent; ethane, smoke, constituent; propene, smoke, constituent; propane, smoke, constituent; methyl chloride, smoke, constituent; propadiene, smoke, constituent; methanol, smoke, constituent; , acetaldehyde, smoke, constituent;
Page 799: wrm95d00
INEIALATION/AIR POLLUTION--HEALTH EFFECT/TOXINS--BIOi.OGY--FiANDBOoK/ RADIATION-BIOLOGICAL EFFECT/ /ANTIBIOTICS/ FUNGICIDES--TOXICITY/HERBICIDES--TOXICOLOGY/INSECTICIDES--TOXICOLOGY/ NERVOUS SYSTEM/PLANTS--AIR POLLUTION--EFFECT/PLANTS--LATIN NAMES & CON11`40N NAMES/ ANIMALS-LATIN NAMFS/ /NEURO-BIOLOCY/PARASITISFi--BIOLOGY--HANDBOOK/ Biology Data Book Second Edition VOLUM E II CoWnt= exn aataZn sx Philip L. Altmin amd Dorothy S. Dittmer Fedentioa of American Sociecies for Experimeaczl BioloBY ="Mv.. Wasa.um 1 :. _W
Page 800: wrm95d00
50335 3312 /FOOD--TO%ICITY/ SUCROSE/GLUCOSE/ CARBOHYDRATES/FAT5 AND OILS/PROTEINS/ANIMALS--PAAItMpCOLM/ Toxici~ty of Pure Foods ...~ _ 8 DL 16,d (&cem"i, pi fimm E.aits of lhwm..Ip, O.er.'s tJnisft t4fra..0.dcio. G..d. : ~ 3Oi 1-3 1o, ~ l .~ '. SOW br. Cad E Boyd. M.D. CYiet. DM Idonmtioe Bullet:n D7.isioa li411Y Preftaioe Brsncb Nrm a.d wdbn Gnad. Ous.a.Onurio, Gmd, .
Page 801: wrm95d00
FOOD-- ADDITIVES / BIBL.IC±GItAPHY/PESTICIDES/STEROIDS/ENZYMES/ NATURAL PRODUCTS/CHEMICALSI S paaphl.ets : METbBOLISM OF FOREICN CaMp04NDS : AN Al1Ntn'ATED BIBLI0GRAF11E. BY ANTHa2dY J. V'ERBISCAR, Ph.D. TOZICOLOGY IiiFOR."'.d1'ION RESPONSE CENTER Work Supported by the Toxicology Information Program, 1liational Library of Medicine, National Institutes of Health, 'ORNL-TIRC 72-VB1-June 30, 1972, - OR2M-TIRC 72-VB2-Sept. 12, 1972 ORHL-TIRC 72-V83-Oct. 1, 1972 OffifirITRC 72-VB4-Dec. 29, 1972 0II?iL-TTRC 73-VB5-Mar. 29, 1973 Department of Health,'Education, and Welfare ander t-z2b-dEC Interagency Agreement No. 40-274-71 OAK RIDGS NATIONAL LABORATORY Oak Ridge, Tennessee 37830 operated by . ffii0H CARBIDE CORPORATION #ar the I V.S. AMC Eh'ERGY CwISSioN libliograph' is divided into 12 subject categories: General articles, lkvieas, and Books; Therapeutic Agents; Pesticides; Food Additives; Veterinary Products; Steroids; Natural Products; Industrial and Experimental Chemicals; Interactions Affecting Metabolism; Theory and Mechanisms; Methods and Techniques; Enzymes.
Page 802: wrm95d00
A. AAddW06d.M.ddWW. 50335 3320 Q /HERBICIDES--TOXICOLOGY/DISINFECTANTS/AIR--POLLU'iION 23 FUNGICIDES--TOXICITY/STANDARDS/ ~<. Title and Subtitle y K.L.rt Uate AGRICULTURAL CHEt'SICALS AND ESTICIDES July 1977 A S(lSFILE OF THE REGISTRY OF TOXIC EFFECTS OF CHEMICAL SU9S"IMCES d 7. Author(s) L_._ _~ < Edward J. Fairchild, Editor 9. Pesfora+ina Orjaaization Name and Aidress Tracor Jitco, Inc. Rockville, Maryland';20852 JVio5N=77 /8'0 1, rt'etlmn~ej Ortsnizatioe Rept. No. 10, pt~'o'/Task/Y'ork Uait No. 11. Gwu.ct/Gtaat No. 210-75-0034 12. Sponsocinj OrRanization Narae and Address ~ 17, 17p. of Repon & Petiod National Institute for Occupational Safety .ans1 Health Coveted . 4676 Columbia Parkway • Cincinnati, Ohio 45226 "/4. ia Absttacta - ~- -_ This is the firat edition af the.subfile of agricultural ehemicals and pesti- cides extracted from the NIOSH Registry of Toxic Effects of Chemical Substances. It contains 2190 substances that are used to achieve specific agricultural purposes. The subfile was prepared to provide toxicity data in order to facilitate the provision of a safe he lt , p en r m~t r~ 4 myVencountering agricultural chemicals at all stages~f~e~n9 ~nt~(es~, ~ormulation.and use. Tho ...bfsi. _ak& liRC coatprenenszve in 9
Page 803: wrm95d00
50335 3316 RA 576 Cl, •197 7 AIR--POLLUTION/WATER--POLLUTION/WASTE,INDUSTRIAL/CHEMICALS--TOXICOLOGy/ /POLLUTION CONTROL/ ~ Ir...crun i rw. 12. EPA-6_00 7-7 36a *' •. TITLE AND SU0T1E MultimediaZnvironmental Goals for Environmental Assessment, Volume I Volume II. MEG Charts and T. AUTHORIS) Baakground Information JJ. G. Cleland and G. L. Kingabury .PERFORMING OPOANIZATION NAIAE AND ADDRESS Research Triangle Institute P.O. Box 12194 Research Triangle Park, North Carolina 27709 12.iPONSORING AGENCV NAME AND AOCRfSS"" "EPA, Office of Research and Development Industrial Environmental Research Laboratory Research ~ri~gl~ Pw kN~ ~71~ „ - ~ n aILE ~' PB 276 919`i- b. REPORT DATE November1977 . PERFORMING ORGANIZATION 19.TVPE OF REPORT AND PERIOD COVEREI a.gk Final: 3-10/77 mSPONSORING AGENCY CODE t~l: ofEicer for thit3 report ia.T. Kelly Jainea, Mail
Page 804: wrm95d00
1 50335 3322 F OOD--FLAVORANTS/FLAVORANTS--FOOD ...,.,,•. . : Sf1 E ET FDA./BF-77/65 4. tt e a Jux a e $• epon 6ate Scientific Literature Review of Alicyclic "DicarbonYl" November 19`l6 compounds in Flavor Usage ~. 7. Aurhot(s) i. No.(ormin& Qganization Kept. 9. Per(orminj Organization Kame aad Address 10. Project/Task/C'ork Unit 10. Flavor and Extract Manufacturers'Association of the United States 11. Coatact/Graat No. 900 17th Street, h'W Washington, DC 20006 . ' 223-74-2224 12. Sponsorie; Orianization Name and Address 13. Type of Repon & Perici U.S. Food and Drug Administration Ce.ered 200 "C" Street, SW ' Final - 1923 to 1976 Wa3hington, DC 20204 14. r ,. 0 9o 0 0 02 5 6 1 1
Page 805: wrm95d00
PLANTS,POISONOUS/HYDROCARBONS, TOXICITY/ „POISONING--TREATMENT/POISONS--TOXICOLOGY/DRii~,$--TO!CICOLOGY/ pICOTINE--PHARMACOIAGY/TOBACCO--NICOTINE fi1+rSECZ CI DES--TOXI COLOG : .;f . f M ~-NDUAL TOXICOLOGY/ ~~-- LUTION NEF handbook of ~BERT H. DREISBACH, MD. PhD ~Q C76tlcal Projessoi ojEnrironmenral lfealtA, 123 Dr SdtoolojPublic Health and Community Aledicine. 1974 PO ~ ~ ~ e.1 ~ ~ ~ . Unb'ersiq'ojWasJilngton, Scattle, ~,j111~t , \1 and PDDL w.tft.[ Rsr-a.s Diagnosis Thaatment ftjeuw (Emerftus) oJPharnacoJoty. S!m{fot'd (lnivtnttr School ojAledkint SW4wM, Calijorn(a ~ 1974 EKiHTH EDITION - Lm Altw. Ga4f.mia I 1E74 01 Y .~~•O , .. r
Page 806: wrm95d00
50335 3325 0 ~ tEl E GRAri/1C DATA I1. Reraet ~M"l~ 1 -- ` lfi FLAVORANTS--FOOD A-I PHAT I C TP 983 ,Scientific Literature Reviev of Alipbatic 8ydrocarboas ie Fl Flavor usasesYol. 1. Introduction & Sumnary; Tables of 1975 .1 ... Aa[ . Bibliaglapig . i~~ sc 111/ October, 1975 •. ~rocsias Or&aa3satios Rep M. Prsject/Task/*'ark Uw'r Kv 11. C.Macc/Gsaat lio. ~ 223-74-2224 Rspen & Period Pinal - 1920 to 1975 u. ssuana . . A 1bs Sci"tilie Literature tevev susspri"s the avail.ble scientific literature 0 f }~ 20 0~ 7S~ #~ te of alithatic hydrocarbons in flavor ~. foi#at~dn.~~~io~ut~ ;at~aod Diocl~eaical as cta of these co.po nds ~ibll d . Per/on:u; Ocsas,isati..NasM aad Addresa llavor and Extract Maoufacturer&• Association of the United States 900 17tb Straet, MW Hashi ton DC 20006 ~_ li SpoasariaA orjacisaba Ksae sr Alieaa U.S. Food and'Oruj AAainistratisw 200 "C" Straet,-S1i . .-. _, _. . . ltashinstoa, DC 20204 are Sivaa ia a 226 Vat e 600031 y coatainins a91'reterencaa.
Page 807: wrm95d00
5Q335 3315 Q A, l'itle ancl Subtitle S, ttcport Qote 123 ~ Registry of Toxic Effects of Chemical Substances ' ~~7s•,t 1975 Edition 6. tSfLSI.IOGRAPN(C DATA t• Itc(`ort No. 2• 246 557 REF S}IECT NIOSIi-TSL--75 ~ CHEMICAL COMPOUNDS--TOXICITY/ ENVIRONMENTAL HEALTH/OCCUPATIONAL SAFETY AND HEALTH/NICOTIDIE--PHARMACOLOGY/ CARCIt10GENIC SUBSTANCES/HUTAGENS/ 7. Autitor(s) H E . Chri.i.l:L'LL.' , ddress 9. 1'ee(orminF Urlanir.Ktion Nacic and DIIE(J/PHS/Center for Disease Control ~ &S,National Institute for Occupational Safety and Health 11. Contract/Gronr No. -01 5600 I'ishr.rs Lane CDC 99-74-92 szca,ici 31_e , 'sax~~ U(1 t2. Sponsoring QrAantzatwn Name nnd Address 13. Type of Report & t'rria! A9rj• ,dA.^~ cs,d.1 C~/~ ~.DEPT. COMMERCE, NATIONAL Corcrcd ~,p~l.. / i ... o i 7i~-~-t/. 9 '1`ECHNICJ~I. INFORNATTl1N CFRVTI t? Supersedes Toxic SubstAnees•Liet-1974 Edition a C.~ , The 1975 Editipn of the Registry of Toxic Effects of Chemical Substances, foraterly, known as t.he NIOSH Toxic Substances List, is the fifth Edition prepared in compli with tiie.requirements of the Occupational Safety and Health Act of 1970 (PL-91-59 This e~ t~'~' nt~-n to c~ nf ion on a roxisaately 17,000 uni ue chemic; subs ~ncLss ~1oc~ wYEh~bo~ b8yl sis. Information is given on route of ent~ toxtc dose and toxic effects including an indication of existing evidence of the
Page 808: wrm95d00
._ _ • .. - .... ' ...._ . i lOOD--PACKAGING/AANTIlOA*tS/ OW FDOD--CO,?T/IJ'Q iUIQTS/ s : . . Im ...w o.r. Septes~ber 1, 1978 a a Oww"wa c...Mww ftn~ as•w.w" wo. w ew... Iafor.atics Iac 6011 Hxecutive Boulevard Rockville, !m 20852 SaM1926-23«+ ww w IL Or.tieMq .r G.a.M Mw p t11A 223-76-2001 ss ' tL s,oin«-& o*f•Wal" wa.... A.r.q t& ty.. M..r.A a r..». o.r.... Food aad Drug /4daiaistration liaal: 1920-1978 200 C St. Stil. • ' Wsh.ingtoa, D.C: 20204 .• The Monograph su..arites tbs available scieatifie literatnrs fros+ 1920-1978 related to the safety of wathylpolysilicones. Cheaical is2orratioa,.biological data, SAd biocbe.ical iaspects of thesa oo.,Qouqds are coatais.# io a SS pase sm.ary oontainiag70 reteireac:i. . • . • • .: t t1~S6~~1 0 5p0-V
Page 809: wrm95d00
~r r c¢~FKTATIoH'ka.oR.~/BF-79a/ s PB 291105 ~ TP Scientific Literature Review ofAcetophenones and ~` a;"i97a I197s -introduction and Summary, Tables of Data, Bibliography%.•~•.a...w«..mwt«.. 983 ,Retated Substances in Flavor Uiage, Volume I F1 'PDDL 1. c• Flavor and Extract MeauFactarers' Association of dr Naited States, COWWWWO •• 9ftom N.. Washington, oc I.Y• W 223-74-2224 iA ' 2L GoOkW1w4r«.~s. . - ... ,._.' •i•, . • . ~Methylbeg syl 4lcohol/s•.IdethywatYl fQimste/ vk,Ijethyibeuayl ac6tateL p!=Methylbettsyl* propionatp/da,Metfiyl~bazyl butyratel- C-,,-Methylbeirsrl 3rebutyrat
Page 810: wrm95d00
50335 3324 FOOD--FLAVOP.AtJTS / FLAVC1RA1rTS--FOOD / BISLtOGRAPMtC CIATA 1. Kepon No. s Aeeeaslon ..... SHEET FDA/BF-77/62 p e a StalJc ~. tP9. OR att Scientific Lit ature Revv of Aliphatic Di- and Deceber, 1976 •_ , Tricarboxylic~acids and klsterV in Flavor Usage i' 6. 7. Awlo((s) 9. Per(orminj OrSaniration t:ame and Addtess Flavor and Extr2ct Manufacturers' Association of the United States I 900 17th Street, Nw Washington. DC 20006 . Washington, DC 20204 1~. 'The Scientific Literature Review summarizes the available scientific literature from 1920 to 1976.related to the safety of aliphatic di- and tricarboxylic acids and esters In flavor usage. Chemical information, biological data, and biochemical aspectd of 'these conpcnnds are given in a 173 page summary containing 497 reference. _--,. - _ -- ~ 12. Spoototioj OrSaoization Name and Address U.S. Food and Drug Administration 200 "C" Street, SW 0_'5 00©025 .6 1 ~ t. Perfoe.ins Otjanization Rept. No. • 10. Projecr/Task/Work Unit No. 11. Coevaa/Grsat No. 223-74-2224 13. Type of fleport k 1'eriod Cetered Fi.:a1 - 1920 to 1976 . . .i ~ .
Page 811: wrm95d00
50335 3323 TP 983 F1 1975 PDDL ~ FOOD--FLAVORANTS/FLAVORANTS--F00D/ ~ Bts[•1OGRAPHIC DATA i Ntpxt No. t~ `~. Kteipieet's Acerssion \o. SHEET ~ FtkX/BF-77/S4 , 4. t. C~'~• ~ 1~ ---""_ ~c~Ent`iftc Literature iteview of Al:phatic Acetals in Flavor Usage ~~ , . '. . . 7. AtKho:(s) 4. {"ct(ocminy Ocjantaaaoa ::amc and Addrzss , Flavor and Extract 2ianufacturetst Associ++tion I ~ of the United States 900 17th Stre2t, t~'W ' L- ~ {,'ashingtoa, DC 20006 • a I~--- - - 12. Sronxoeint (k:at.izscion tisme and Addcess U.S. Food and Drug Administration 200 "C" Street, SW Wa3hington, DC" 21)204 . - S. kcpwt Uatt - - September, 1975 a• Ircr(a;minj Ussai:at:on kspc. Wo. 10. Pcojeet/Task/1:ork t:ni; :~o. 11. Coouact/Graat Vo. 223-74-2224 13. Type of Repott & Fretiod Covered Final - 1920 to 1975 14. " The Scier:tific Literature Review suauoArizes the zvai'.able scientific literature fron 1920 to 1975 related to the safety of aliphatic acetals in flavor usage. CpF-i~1~form7tion, biological data, and biochemical aspe:.ts of these compounds s~ g e n4(~a~ st~a.i&'c~ta~in~ 254 references. .
Page 812: wrm95d00
CANL"ER REVIEWS/CANCER--RESEARCH/CANCER--CONGRESSES/CANCER--CAUSATION BY CHEA;ICALSI BENZO(a) PYRENE /HYDROCARBONS, POLYCYCLI C--CARCINOGENES IS BY/CANCER--ENZYMES/FLAVONES/ CANCER--BIOCEIEMISTRY/TOBACCO--SMOKE--BIOLOGICAL TESTING/ ARENE OXInES/ NUCLEIC ACID--CARCINOGENIC ACTIVITY/AROMATIC HYDROCARBONS /DEOXYRIBONUCLEI C ACIDS!. TOBlCCO--SMOKE--POLYCYCLIC HYDROCARBONS/ SerieaEditor The Biochemistry of Disease Emmanuel Farber A Molecular Approach to Cell Pathology Ta^ple Un+re.sity A Series Of MowVraphs P!.'Welrkia, Pannyslosn:a 261~5 y°u"e` ~C~hemical Carcinobenesis 1974 (in two parts) - -- - Part A Seteeted 1'apers Prescxted at the Wer{d Sympe+-rm on Hodcl S.udies in Chemicel Careipaopenesis pddat The Jekws Xopkinxaledieal Institutio+u, /taltimure, 3tarylard - L _ _.~_ Oct~El .tl-NOOehtber S. IlFls Edit~d by Paul 0. P. Ts'o and Joseph A. DiPaolo TI-e Jofrne Hopkins Unii;ersity National Caxccr Instilute Ballimore, d/aryland Bethesda, Slarylartd MARCEL -DEKKER, INC. New York 1974 I .1
Page 813: wrm95d00
t' ' `~ RV rN1'1 AnflTTTVrS/RF'~*•nf~1pVrF~iF/`~AT .r~YI~~V •r..• •.1. REPORT DOCU[.ME-NTATiON 1zREPORT NO. PAGE FIlA/BF-78/91 4. Title aeA fubtstti. Monograph on Char ~ ke Flavor XX ypr,s-7R S.p. L (SNnYF.n) /FTS'1, 50335 3317 J~'h0IAn Hso.0 S. R.PaR Gat• December 6, 1977 t 7. A~b) , i. Performing Organlaatim Rpt. N.. Richard L. Dailey 76-1926-04 ~. r.rf.r+wlng Orsanitation wune ana Addr.ss U~~ • . T f0. hajoct/To:k/Work Unh No. Tnfermatica Tnr_ ) 6000 Executive Boulevard /j `- 11. Contract(Cl or GrantCti) Na i Rockville, Md. 20852 4~ y~-~ '= 223-76-2001 ~ I ~I, ~. T1nn3LL'!~r± l'Q 1L tponaorinL O•L•nuctron Namo and ItdOross •• c i~ n r r, V• 13. Typ..f R.port :.Food and Drug Administration & hrlod Covor.d ~ 200 C St. S.W. Final: 1920-1977 wsel.inaton, D.C. 20204 L. The Monograph summarizes the availgble"scientific literature from 1920 to 1977 related to the safety of char-smoke-flavor. Chemical information, biological data, biochemical aspects of this compound are given in a 52 page stuumary containing 449 references. 05-0000Z560b-~"`-~' and -~ -- - .~~ +ea-rs
Page 814: wrm95d00
' BIOFLAVONOIDS/ /FLAVONOIDS/FOOD--INGREDIENTS/ sdin -~ o~ . .. TP REPORI DOCUMENTJITION r iz,REroRT MO. L ~+n+~, Ft~/BF-79/26 PAGE n 370 .- Un .. nw ... ar.an. z s•v•c wa 1978 • ,• . August 21, 1978 lDDL ~ Honograph• on Bioflavonoids ' `' . . • . ~ . .~ an I ~ ~ , Halter F. Bauer . • 370 m ~ p"t"'"MS o.ts*aaw t+.nn n.e A.*e.. Un N Informatics Inc 991,90 6011 Executive Boulevard $ockville, 1~ Zv~3~i w~ • 3!. iOM~M~f ~ and Drug Admin Food 200 C St. ~I. ii~tshington, D.G: 20 . ~ •..~. ~. ia F..i.esls.+~rvw..t V.r~ N.• IL C~..cKQ .. G~.wttC1 R.. = FDA 223-76-2001 A ws MMMS li. T~p. K R.ooR 1i here co . i stratioa , Final: 1920-1978 204 T'he Monograph susmrises tht avai7.abic scientific literature from 1920-1978 relate ' to 'the sAfaty of bitsflavonoits: .Chemical information, biological data, and biochcsqecte of. art =taimd in a 103 page. s~moarg. containing 364 =efe
Page 815: wrm95d00
ACIDS, ALIPHATIC/ALDEHYDES/ESTERS/ / FLAVORANTS--FOOD/FOOD--FLAVORANTS / e16LtOGRAPHtC DATA L Reyon No. Z' SHEET FW BF-77/60 4. Title aod 5ubtit 11 Scientif,t,t Literature Review of Aliphatic Keto- and Hydroxy-•kcids with Nonadjacent Oxygen Functions and Related om unds i F avo U a e f . Asshot(s) Pet/orninj Qrsaaizatioa Nioe sad Addtess Flavor and Extract Manufacturerse Associatiot: ~ of the United States 900 17th Street, N'a Fpc _ 20006 12 Speosotias Ordasisatioo Name aad Addtess U.S. Food and Drug Administration .200 "C" Street, SW Washington, DC .20244.. . -. a 3. Reeipitat's Aeeession No. S. epon Date ~tober• 1976 •. ^ i. Petformias Otsasization Rept. No. 10. Project/Taslc/s•ork Unit l:o. IL Coeusct/Gcset No. , G„1Z1_74-22_H I11 Type of Repoet & Period Coveted F 1- 1920 to 1976 1~. The Scientific Literature•Review suamarizes the available 'scientific literature from 1920 to 1976 related to the safety of aliphatic keto- and hydroxy-acids with nonadjacent oxygen functions and related compounds in flavor usage. Chemical ioforaation,-biological dat a b oc~? ical aspects of these compounds are QivcK L~t ~1 ~e~umt7ryton~inig al6 references. ,
Page 816: wrm95d00
50335 3327 ~ FLAVORANTS--FOOD/. FOOD--FLAVORANTS/ . ,. 6IBLIOGRLPHIC DATA 1. Repac N.+. ' 1 3. ReeiPieae'a Aceesswn SMEET FL1kBr-77.r5? 4. u a, a,,;,t t e S• epon Uate Sc ent~ ic~/~ iterature Review f Aliphatic 'etopes, April, 1976 ' SecondaryyAlcohols 6 Relate Esi.ers in Flavor"*Usage . 7. Atsw or(s) 12. Spoa~ int Ot8aoization Name and Address . 13. Type of Report & Period W. S. Food and DruP, Administration Co•ered . WnplSington, DC 20006 . ' 223-74-2224 90O 7th Street, NW = of the United States i11. Coauact/Gtaoe No. vFlavor and Extract Manufacturers' Association ~9. Psr(or~isj Oraanizatioa Name aod Address 110. Pro{ect/Tssk/t'ork Unit No. 200 "C" Street, SW ~ 8ina1 - 1920 to 1976 and_related,esteys_ in flevox usage. Chemical inforaation, biological Aata, and , biochemical aspects of these compounds are given in a 458 page summary containing 1559 references.. - ~ ,. . - The Scientific Literature Review summarizes the avaitable scientific literature from 1920 to 1976 related to the safety of aliphatic ketones, secondary alcohols I Washington, DC 20204 '+m 0~00'00 25 b.~V6 , 4 .
Page 817: wrm95d00
TY : 50335 3328 .a gmT~.__FLAVORAA'TS/FLAVORANTST-FOOD/ 983 BIBLIOGRAPHIC LIATA 1• RePurt No. F1 SHEET FDA/BF-77/62 1976 ~4, ,t e, aubiu e RDDL Scientific Literature Review of Aliphatic n.actones in Flavor Usage -- ~ 7. A~irclw.t) 1. : ettorniss Ortaeization Name aad Addtess . Flavor and Extract Manufacturers' Aasociation ~ of the United States 11. Co.uau/Graot No. 900 17th Street,'NW Washington, DC 20006 a• 223-74-2224 12. Sponsoeias !ksasization Name and AJdress 13. Type of Repon ic PetioJ U.S. Food and Drug Ada'_nistration Gvsred 200 "C" Street, SW '6.''• • Final - 1920 to 1976 Washington, DC 20204 1~. The Scientific Literature. Reviev sum3rizes the available scientific literature from 1920 to 1976 related .to the-safety of aliphatic lactones in flavor usage. Chenicai infotoation,'biological data, and biochemical aspects of these compoun.:_. 1 are ;iven in a 169 page sunl.ary containing 243 references. . i ... ' • '~- ~ s' 0 0 0~ 0 ~ ~2
Page 818: wrm95d00
50335 3329 FOOD--FLAVOP.ANTS/FLAVORANTS--FOOD/ TP 983 •F 1 1977 PDDL r' BIBLIOGRAPHIC DATA 1. Repoa No. ~,v~_77/66 3. Kecipietu's Accession No. SHEET ~• K c ano ~• :u e eport ate Scientific Literature Reivew of ino•Acid6 in Ftavor Usage Februarv. 1977 . =- . ~. 7. Auchot(s) 8. Nc rtora-inR (ktaniz+tioo Rept. • o 4. PetlotmraS (haasizaeioa Natnc sod Address 10. Ptoject/Task/abrh lbit \.t, Flavor and Extract Nanufacturers• Association cf the United States 1t. Cosusct/Grsot No. 900 17th Street, NW -= • WasttinQton. DC 20306 • ' ~ 223-74-2:24 Sponsotinj (h6zoizuion Irarae and Addtets 13. Type of Rtpott k Period U.S. Feod and Drug Adminintration C°'e'ed 200 "Ctt Street, S.W. Final - 1920-1977 Washington, DC 20204 IS. Srpptetocotsry Notes r• 16. Abstrscu •The Scientific Literature Review summarizes the available scientific lit::rature f m 20 0 77 rel te to he f t of amino acids in flavor usage. Chemical 0 i~or~ti~. ~ol%ir~ a~andf bihemical aspects of these compounds are given in a 133 p3ge stanmary containin& -68 references. . _ . .._._ . _._.-• - -- -- ---.. . . -- n
Page 819: wrm95d00
st-10 1 „ ~ ROVQT OOCUMEN~AiION j I, ~uMt uo. MaE , fl~1/RP- ~148 Scientific Uterature Review of innamyl Alcohol and 1978 Fl Introduction and Summary, Tables of Data, and Bibliography .Zea.w••r•• ••^•. ?p ° - ..Ax 11o7. 983 Related Substances in Flavor Usage. Volume 1- 2 C. ~~t' Fiaror and Extrad Manefacterers' Association of the ~uited Statos, . ,~tabia~toA, D.C. 1 Mi M.ftw1y OMWAMw. ++..u w M~.r ..uw.nww. u.aw.C«a«s..alm «.. 0 223-74-2224 A &i To..! R.aMt & hrW OrwrM fiaA1 report I ~.y~e_i9~s ~...
Page 820: wrm95d00
FLAVORANTS--F00D/FOOD--FLAVORANTS R£PORT DOCUbiENTATiON j.4 Tp PAGE 983'sm""'' .a" ,0. FDA/BF-78/121 I ~ PB 283 R.;..e ~ oa ~'O' - E Fl Scientifi~ Literatu e Review of Aryl Subs ituted June 19j$ 1978 p~m~%Y,,~cohols, 1l(ldehydes and Relatedvsj~es~ in F~a 'nA S nmearV - a es o ' PDDLI Data, Bibliography L Metoe~tns o~.M.~ F ~k- hR.m-iMS Os.n*sa.w N.wM s Flavor and Extract ~inau~ictutrs' Association of the Onited Stat P-19dr.+aw.ra we r FF1dA 900 17th St. D1W Washington, D.C. 20006 1t. s."+MMS OrewAftNm Naw..M Ads..s FDA 200 C St. SiI Washington, D.C. 20204 li. Co~trsct/C1 ..Or.Aq~ K Im 223-74-2224 Ka li. Tro..1 R.eMt a.e.iw c final report R u
Page 821: wrm95d00
- S0335 3332 FLAVORANTS--FOOD Fl Flavor Usage. Volume I. Introd _u_ction and Surn,,a , `~`"""'`"` - 'y~ •. _ s83 enzaldehyde,+'Benzoic Acid and Related Substances in' TTp ~entific Literat re Review of ' enzy! Alcohol, • ~ ' I • PAGE I F94/BF-T9/46 {197s 1 abtes ot Data. Bibliography " `- .'a eftiod""y""" U'u""., Z ~ ,DL Hayor "and Extract Manufacturers' Association of the United St ates, " °~"°' w W~'"0 ' 1 c Whi 'osn~ton DC M. • q 223-74=2224
Page 822: wrm95d00
S0335 333• RCAICIC AC1DS/ t!000-FLAV~RAIiTS/F'LlIVARANTS--F~1r~D , I Scientific l'terature~f view of Com~iotl Mixtures of• Aideh des Acids" and Related Esters kohot nc tt ti Ar h & y s c aC79 p a -,, PB in fiarror Usage. Volume i. Introduction and Summary, 296010 Tables of Data, Bibliography a ~».^ aN March 1979 a hil~rw.M.L Os.w+r.M+ R.rf. w~ FMrsr ..1 Extrod Msasfoduras' Assodatioa sf the United States, a. .M.e+R..vW... u.. «. ., PEMA ~ .. . $00 17th Street aL c..K..a,n .r c..r.cw w. Washington, D.C. 20006 j``"c'Ort MO' ~% ta 423-74-2224 . Aw.'~- wC.ws..... .ww ..~ w.w... 1. ' 13• iw..f /LpR & h.iM C...rnM "~~ c~,~ Final report ` .I r FDA '~ C Street. SM. IVashit~ton. D:C• 20204 ~t " .!i4'~• 1 1920-1978 : . 7lds manogiaph contains a collection of data from the published literature from: ltll0 to date. VnpilDlished data from private industr.y files are also contained in the mono-. graph. These data eover the specifie group of structurally related eompounds 6esignated in the tithe• Inclvded in this revie.w are data on toxicity and metabdUsm, usave end natural oecurrence ia foods, and eompasitio9al specificatians.• 71iis Is a SI page review containing 8? teferences. . . t)s. ouulrut OF towtiatx - ti.uo.d t.cb.kal ww.nG.. sn.x. ._. o~o~oa2sa2 3 F
Page 823: wrm95d00
,. - 50335 3335 . .. ~ --.• ------ V _~ ~____ ° ' -- -- - --- FOOD--FLAVORAh'TS/FLAVORANTS--FOOD/ ~ iHEET M$F-77 63 . lu c Ar. Ju tule S. Kepwt Wte ~ Scientific Literature Review of Diketones, Hydrox etones and October, 1976 _ TP Simple Derivatives in Flavor Usage - 6. 983 F1 •~lw.huc(s) !. F'ec(orr'aunx Orraniaatr4n Ke . . . • ~o. 1976 i,etlorv,in Or ani:ation l~ane and Addc:ss pD~ d d . 10. Proleee/Task/1L'ork Unc: N Flavor and Extract Manufacturers' Assocation • esf the United States • ~ 11. Cootract/Grant No. ~ 900 17th Street, INN 223-74-2224 L Sponsorcn6 pr;:..iation rlame aad Addcess . 13. Type of Report & Period U.S. Food and Drug Adaninistration • Coveted 203 "C" Street, SW Final - 1920 to 19', `~ Washington, DC 20204 14. i t ~ - • ~ ISM svpplcncntery ,o:es .16. Aps:racts . The Scinetific Literature Review summarizes the available scientific literature form 1920 to.1976 related to the safety of diketones, hydroxyketones d simple I' er at~' es(~ n ~+} av ~R~ em~ al4nforetation, bioloCical•data, and biochemical ~sp~ts~8f wtes~coaoutids lKt•e~ivdCe in a 129 page summary containing 400 references:. zz-_--- -
Page 824: wrm95d00
.--- 4L xu Hec _79 Scientific Literature Review of uranones and Related "D~. 1978 s~ Substances•in Flavor Usage. Volume I. Introduction and < '5Summary, Tables of Data, Bibliography "'""""" °'*'"` .Flavor and Extract JNanufocturer's Association of the . United States, Washington, DC ' iiaabinstoa, D.C. 20006 lJH.A4~- aa ...:svT...nr«+ uMe PO& u e.sakuc, .. ce..Nw r»6 o 223-74-2224 A t~.ts" «R•..wa..««ci.. , final report IMM • ' ' . - . . ~ ' 200 C St.l St7, Washin=ton, D.C. 20204 x, hs8.; ~,_. ... .. h ~ec"sz~ou '~~ IL 2-1[ethyltetrahydrofuran-3-one/4-Hydrozy-2,S-dinethyl-3(2H)-fur.lnone/ 4--Hept)rldihydro-5-methyl-2(311)-fur~tnone/2-llexyl-4-acetoxytetrah4drofuran/ , . b 4f . H..~Z REppRT DUMENTAiION ;+ti.RCwat ~BF-79/47 • s PB 29~.~{ ~..~' 1 - = - ftft..wMft Or[.wftn.w Maww w OA.a.s
Page 825: wrm95d00
4K3 50335 3366 FLAVORANTS--FOOD/FOOD--FLAVORA:d?S EIBLIOGRAPNIC CATA 1• Kepore SIiCET FElr1/BF-77/S94. Hle an ~ut,f• e Scientiftc Literature Revtev of opylene Clycol., lycerol and related Substances in Fluvor Usage k • 7. Archorls3 9. Petformins Organi:arion Name and AdJreas Flavor and Extract lt.inufacturers' Associati0n of the United States 900 llth Street, N'u Washington, DC 20006 r •r roe Ne. 11. Coeuact/Gr.at .`e. t3-74-2224 12. Sponsorinj Orsanizu%on \une and Address 11 Type e/ Repott ar Period U.S. Food and Drug Administration Co•ered 200 "C" Street, SW : Final - 2920 to 1977 Washington, DC 20204 The Scientific Literature Review summarizes the available scientific literature from 1920 to 1977 related ts the safety of propylene glycol, glycerol and rclated substances in f2aaor usage. Chemical information, biological data, and biochemical aspects of [hese compbunds are given in a 217 page sumroary containing 836 references. . . . . , 0`-500•tt0756~5 11 .
Page 826: wrm95d00
lLAVORAIITS--~OOD~900D--FLA'VO1tAnS PROPANOL, 3-PHEM-/ 1 _ • ' L lwftming o.g.wts.Nse R.ot Na 983 • wMa• s. awo~e o.a F3 Scientific Literature Review of 3-Phenyl-l-propanol y~.19J$ 1978 and Related Substances in Flavor IIsage- Vol. 1. & M~ cEr~rrrAr~oY~ ~~ 78/119 L ~ i/~ tU 2 ~` 5 ~ i; it- ?DDL oro"an.w Ne~+o a" AMr+s« llavor and 8xtract Manufacturers' Association of the United State F§A 900 17th St. 8W Waabington, DC 20006 tt s06OWsrs Orpwis.tNn M.m..M /tNir.as FDA 200 ; St. S.W. Washiagtoa,-D.C. 20204 Ia hoj.evr.,kAw... ude Mo ia
Page 827: wrm95d00
In TP 983 71 1978. 2 . PDDL 1 C. 3) ,r- j&OAT OOCNMEN1AflON .4.~crowr wa rA" 1 rUVBF-781133 [x/COLI -)»:. 4. ..nwa.... % I ~ • 116 0004 .w ' ntific Literature Review of Substituted 'AdY w7e nzaldehYdes and Related Compounds in Flavor tlsage ' 'Voturhe 1. Introduction and Summary, Tables of Data, and Biblioaraohv 8% "`"wT"'/'"""""n "'` fiavor and Extract Manufacturers' Association of the United States, Washington, D.C. f w e:zs-ie-ss=• Mashington, DC 20006 , IM .P , ti i a eW°„ of data from the puWtshed literature from 1920 tn ~~~~` ~ - ~' Il' 3 A& -•
Page 828: wrm95d00
Tt 983 F1 197 PDD t. Svo~+wMS anoK•ew N.ww .we AMwss FDA A ~~ 200 C Street, SW, WasMngton, D.C. 20204 , / L This monQEr~pil,cQn>~_a.~collectior~ of data from the published literature from 1920 to date. Unpublished data from private industry files are also contained in the mono- ~~ graph. These data 0BV~''ttx~'a~ttic group of structurally related compounds designated in the title. Included , ir1 this review are data on toxieity and metabolism, usage and natural - r ~ . OCCt1IT~RC~in wor 50335 3339 s.~r: •~orooD--~voRAx•rS/~vox~" TS~ooD - 0 REPORT DOCUMENTATION sL~Ero~e8140. s. o i• 1 FnA/BF-79/ 99 PAGE 29t 76 4. TIq..M fre~urio Scientific Literature Review of~daltqi and Derivatives in Flavor Usage L R+~t On. Januar 1979 R 1. ArpWMs1 i. M1.e~w:+= Os.MS.eNw 11ore e+ ~. MAorw.ln: O.~owlsat~n Naww oM ANnss ~0. Aej.cf/Tak/WMt {M~it Nw FEMA (Flavor & Extract ManufaGturef~s dssoc. of the U.S.) 9001?th Street u• e."..ceca .r ~..~ ~+.. Washington, D.C. 20006 A 223-74-2224 • aa ' Zi. T:.. M iiov.~t ~ h.i.0 0..... • Final report • ~ 1920 1978 PvaM a r wLd I Imi1gs iL ~ idi Uons. Wn is a 66 page review containing 4
Page 829: wrm95d00
ppQD-- y 1VOR/~TS--FOOD/ • EtlGlliOL~ _ - -EENZSNE, 3, 4-DIMMO7CY-I-VIIiYL- REppRt pQCUMEMAYWN !•- ~~_78/116 f ~ I - - - ~' [j 'm ~, TP 983 Scientific Literature Review of 71- Eugenol_and R_elated Snbstances in ,-.-1978 ~ -4.-~ r=_ 9. "WPWI Do. MAY_197R a r.R«P+s os.WAMc- a..+. ww I~ asM~c.a.n M.~. w A.d.s. lw /rw•cflt..r1w..% wwt M.. iror i Bxtract Nanufacturers' Aisociation of the United. I TP!!A' States it. oopc....*(a «w.WO '''., ~ 900 17th St. U.W. «a 223-74-2224 .' . Yubingtoo, D.C. 20006 rDDS. ._. : Eugenol, three of its esters, and ~ -Washingtvu, D.C. . 20244 tbescal structure. - - i lbis monograph tootains a collection of data from the published scisatitie..litsraturav.fao•-1914-to date. Unpublished data from g • private indust files ae also contained in the sonograph. These data +porer"'L~~ci~ic,Sioup of structurally related coapounds . , ree 3s• Trv.• R•oe~t a r..~w ceHw. t ~ s""'~~°~"1se~ ~~~" of its eaters, and both its methyl a d . p" ethyl ethers; and 3,4-disethoxy-l- final report 200 C St. W.W. vinylbensene, a substance of similar
Page 830: wrm95d00
XX MeCS 79 F00D--Fi1lYOBA~i'tS/FLAVORApTS--lDOD/ S.P. kRC.oRr NO. IdENTATM~N I ~~ ~V RLP PAGE • FT1A/P.F-78/122 0 Scientific Literature Review of enozy-acetic acid ~ (. .IJ- d related coepounds n f lavor, ugage jO't aa ~ ~L- - L A~ r~ FEKA 900 17th St. N.W. Washington, D.C. 20006 N, IwOeNTetliMl.ek Unlt ~b. uae«.c+oa..c..rAM a.. sa 223-74-224 fi sMmwMS 0jftoVeft N.nw..w0 ANr.q Ii. Tns d asa•d t h.hd C.r..q 200 C St. S.W. final report Washington, D.C. '20204 . 1978 This aonoaraph contains a collection of data from tbe published literature fro. 1920 to date. Unpublished data from private industry . files are -also contna•ed'bc tlfavot[agraph. These data cover the specific group of struC.turaaly.•selated co.pounds•designated.fo the title. Included- in rhisirelrisat ars data on toxicity ana setabolisM, usage and natural 9 occarreace.in.foods, and tospositioaal~specificatioas. ihis is 9 49 ~r T.-~. ~.~t~n~ ~-~e~ .7 ~.~
Page 831: wrm95d00
9.II olqo I H REIORT ~E UENiAIwM ' k•C.w..o. ~~ a ~ r 1~ 1 ~ PB 291115, IL .M. ... ir.wi. . Xx Hecs yAcientific Literature Review of alkylates and s•p• VSalicylaidehyde in Flavor Usage. Volume I Introduction and Summa , Tables of Data, &'biograph ..rw~+.~ asw.,.« w..@ w ~w.... flavor and Extract Manufacturers' Association of the - United States, Washington, DC VaiAlAjCOi1, Y.b. svvw . . 1s ft •rDw • ioo C St. sa, Wasbiugton. D.C. 2o2ot
Page 832: wrm95d00
50335 3347 lLAVORANTS--F00DIFO0D--FLAVORANTS/ :o27t -1 1 gPORt Q~lAEN7ATION 1h1T "0 KNJBF-79/93 PB 2960t & Tw..e. sv.ael. Seientitto Litenture Review o idine NO Related Substances In Flavor ' ~ r..t4.. ~ 0• . Vaa"; - W . t . ~~:~-~• c~*~.~ .a . ~,.M.~«+~+~ ~ - ~ . r. . 7. AMMrl~I tL 1WNWAM OnPfttWM Mam Md Ar/eWN FBMA (Flavor d Extract.Manyfacturers Assoc. of the U.S. 90017th gtreet AL cowe""aa or G""tcc' "` WasMtgtott, D.C. 20006 . . eo 223-74-2224 • ~ ~~8 FDA 200 C Street, SW, Washington, D.C. 20204 . ...f. _ .. . ._l,, __ .. C Final report 1920-1978 ~ ~ TRis.monogreph-contains a colleetion of data from the published liter t f om a ure r 1950: to date, Unpublished data from private industcy filcs are also contained in the mono- graph. 'SAese data cover the snaw~t. vr.om #%r.*.~M...-..~,.. _.._._~ _ . . 0 soo0 0 2 5 b3 6
Page 833: wrm95d00
50335 3352 T 98 F1 ~ 197. PDD i 0 LAVORANTS--FOOD/ FOOD-- 4.'('iile an~ubi~t e' ' Scientific Literature Review of SubstitutedYcyrazines iii Flavor Usage , VOL. 1,Introduction and Summary Tables of I Data; Biblio~.raphy , FLAVORANTS/ uctoder, 1976 6. 7. Amlstrr(.) 9. Pcrforming Organization Name and Address Flavor and Extract Manufacturers' of the United States 900 17th Street, NW Washington, DC 20006 As soc ia t ion a r 112. Sponsoring Organization Name and Addreas U.So Dept t;ealth, Educ. & h'elfare, Food & Drup Administration z.VV ~. o~t.cc~, JN Washington, DC 20204 • The Scientific Literature Review summarizes the available from 192.0 to 1976.related to the safety of substituted pyraz Chemcial information, biological data, and biochemical aspec are given in a 187 page summary containing 130 references. ' 0 5 0 0- 0 02 5 6*4 i 8. ('cr(orminR (kftnnizati(I No. I 10. Project/Task/Work U 11. Contract/Graru No. 223-74-2224 3 13. Type of Report dc Per, Co.cred I Final - 1920 to l 14. scientific litera ines in flavor us ts of these compol e I P
Page 834: wrm95d00
ReE T 55 G G1easnn, ~;arian N. CLINICAL 'lp ;ICOLCCY OF COfiliE'RCIIII, PRODUCTS - ACUTE POZSvasA1G (Sa:*tE & YAM , by Harion N. Gleason, €;cbert E. Gosse11n, aud Harold C. Noc2ge. 1953 va-iovsty ?.~ged The '«tillia::s & Wilkins Co. La2t3more, Nd. , , 0 5 0 0 0 0 2 5 6 4 3 50335 3354
Page 835: wrm95d00
Y 50335 3341 ALCOHOL, ESTERS / 1a»4a • •~ . . A,.i- - R[pQRr pOCU7KENTAiION ' h.at."t No. _ s. ~ PA6E ~ FD1/EF-79/54// I Tp Scientific literature Review of henethyl Alcohol and L~ ~~ . 983 Related Substances in Flavor Usage. Volume I S. ! Fl " IntroduNion and Summar Tbles ofata Bibtih~ ~ ~ 97sY,a U,o9raPY•ft•~e«w ~ 2 c. *Dt ' 1 c. Flavor and Extract Manufacturers' Associotion of the ' United States, Washinaton, Dt,,,,,;,, aM s.«.." N. ..q.cV T.....a.. W.. M.. Pheuylacstaldetqrde/pheaylacltic acid/phenethylaaine/phenethyl t;ormate/ PRoPIo~~x~tvE .r~n: isov~RArE/ M.~w a..~..M.~ ..~. ~.b... • I00 CSt. Sq, Yashisgtoa, D.C. 20204 . st. Uq.IM.....qr NAft* ~.~3..~i..,~ .©.. i
Page 836: wrm95d00
50335 335• CHEMICALS-SAFETY MEASURES/ IIZDUSTRIAL TOXICOLOGY/INDUSTRIAL CgEMICALS/ T 55 In 1975 (ITI) 7Tie International Tedinical lnformtion IRstitutt . ! CANBIIAZA'RB~11S [USTR1A1 CHEMICALS SAFETY MANUAl . ~ a FOR HANDLING AND DISPOSAL WITH TOXICITY AND HAZARD DATA Published in Japan in 1975 by the International Technical Institute, Tokyo, Japan ~-#A~~~K4~f~r 0500t1 25647 094,6~n,
Page 837: wrm95d00
io1n-to+ FLAVOta'rS--FCxOD/FOOD--FLAVORA*1TS TP r I RE~ORT f/0 . §tEPORT OOCUMENTATtOM . L PAGE ~ FZIA/BF-79/92 a txm ." suee+Mft d _o.a 98 Scientific 4iterature Review of%eyrrole and Related Substances In Flavor F1 Usage. VOL. L. Introduction b Suamnry, Tables,of Data, Bibliogr y 19 Pooleo"dtslSVW"$'"LkTtgZ4A0."M,facturers Association of the 0. FEMA . 90017th Street Washington, D.C. 20006 5"....__ ~., . 399a Ofcenes. O 0 0 2 5 6 3 7 - S. Janua.r 1979 fo, h.i+aITs.Iworti Yat Mw 1L CeM.MtC1 .r G..nt{C/ n., q Z23-74-ZZZ4 sa o.Ir.nAau.. Naw. «a Aee..a, q. T,rv. N R.oas aV.Nee eev. ~ FDA , Final report g3 200 C Street, SW, Washington, D.C. 20204 • 1920-1978 33 This monograph eontains a collection of data from the published literature from 1920 to date. "UfiPubli5lied da.tg from private industry files are also contained In the mono= j ~ graph. These data cover the speeifie group of structurally related compounds desie;nnted in F~. ~. the title. Included in this review are data on toxicity and metabolism, uv,ge and natural ,,,, ,.,._ccurrcnco in foods, and compositional specifiVations. This is a 159 page review eoritaining r
Page 838: wrm95d00
----..........._.--- 50335 3355 " • . , AIR--pdLLDTION--CARCINOGENS/WATER--POLLDTI(W/SNCMNC AND RF.AL'1'H/ ~-- _ T0EACCS--S'10KIGN--HEALTEt EFFT,CT CApCER--CADSATION BY CEtEMICALSI pESTICIbF.S/ ~. Rs.aA •EPA 600 2-?6 155 TITL AlEO sN@TiT~E timation of Permissible Concentrations of REIORT OATC Jone 1976 Pollutants for Continuous Exposure _ nMORMING OROANIZATiON COO . • AU MO li1 0tRfORMtNO OAOANitATiON RtP bert Handy and Anton Schindler .I[AiOAMING OPOANIiAT1ON NANtE AND AOOAi" /0. R L • esearch Triangle Institute HE624 P.O. Box 12194 GONTRACTIGRA r14' esearch Triangle Park, North Carolina 27709 88-02-1325, Tasks 34 an IL ~ONSOAING AGlNCY NAMi AND ADDAEfs 1 TYP! OF s tOAT ANO PlA100 CO 4 ?6 ' g 7a EPA; Office of Research and Development - 14='ON:O~ING AGENCY CODE Industrial Environmental Research Laboratory Rese c a le Park, -NC 27711 EPA-ORD 1S.SU~PL[yfNTA/IYNO Es~~-RTP task officer for this report is Max Samfietd, Mail
Page 839: wrm95d00
50335 3349 FppD_. P1AVOttAMt'S/FL;AVORAN'PS--FmD „ .,,,,,,., ~z RUOttT JucWMENTATIon _K.o*,':M r PAGE Pr ury Dr - i y/ 70 I ~ nw «w sreah. e p Scientific Literaturs Review of Salts qf = boxylic Acids In Flavor Usage 3 VOL, I. INTRODUCTION b SUFQMIARY! TABLES OF DATA, BIBLIOCRaPHY Ei l.A.p«tost. January 1979 a hWhewdft Ors«Mtaw R.m n.ft vs..ws.a.n n.wm .w. A...vs. _ I W Ps~.a/T.sL/W«. u.e qft FEMA ( Fi avor bJExtraet ~ Maqpfacturers 4soc. of the U. S. 3 900 17th Street ' . .0 y Washington, D.C. 20006 L ~ lr.t~ ~ ~t, f~smM+s O~pKtMhw 1[sn~ .M /1Nr.s FDA , 7a ~ 200 C Street? SW, Washington, D.C. 20204 A 1Z TyoM o! R.a«e & P.w+o. eorar.e Final report 1920-1978 ?,py(~~f.,I 'Tt~is inonograph contains . a collection of data from the published literature frt ti,~, 1920 to date. Unpublished data from private industry files are also contained in the grap&- 'ifiese-data cover the.specific group of structurally.related compnuno•desi€ ,~ the title.,.lncludgd in,tfiis review are data on toxicity and metabolism, usage and n, e- • oceurrance In foods, and compositienal specifications. This Is a 58 page revieiv cor q, ~ '116 references. f ~jy~1f -~ 0 0 0• 0.• 2 S 6.' 3 8• .
Page 840: wrm95d00
50335 3345 FLAVORAFTS--FAOD/ ~ u literature iro. 1920 to sats• Oapdblisb.d 41Ita fro. ps rata w sy !! 4 til.a ars ilso 4coataiaed -lo tbe eonogra*b. :: lb"a,lata tov.~C. ,she ap.cific d s d~ 1~ ;1~ t~tU• 3nclnd.d d ~o l ll ' s ~ ---.-.-- ---- -- ...... _ ~_ „ • !r s swosrapb oaatains a ooll.ctioa oL data tras tbe V061isbeeY-- ---- - Ai d t i ~ ~4- (3.4-~lethy e~led3oxy- s~ ~.. v e..- s ftow o..«.. AW1)-2utaAoEre e tiaai report 200 . C Et. :Sii, -ilaahisston, D.C A ~ « awow ~. 900 17tb street pipemnai a=Y3-74-YY4 ; ~fashir,~so n ~son ~ C Pet~os~Yl a~cetata : , = ; .: -,.; . ~~ Flavor and Extract iVtaravfa rers' ~ssociatio® of At ~ted .Siet _., y~ . : z c u stances in Fiavor .Usage. Volume I. lntroduction ;. _ wi~t and Summary, Tables of Data.. nnd 6i61iooraohv fta--w &s-wv- %-PL o• s• P. S 5 b ~ ; .e.. 197Z . Xoc rec -76C+enti ic Literature Rev3ew o iperonai and Re'ateo""""" RFpOfrT O.~CUltEN1AT/0N ~ •~ PA :E j~T ~. _ ~ -.6 . 0 --~ a0atainim 9-1 reietr.oc.s • ~ a . w ts tssra f roap 04 strMF t eo. <ie tus, ssriev ars 4ata ~= taad.city and .et.blisw. nNCp ani watnral ' eecn=reaca sn tcsss, .sa eo.positieaal stecitsoattoas. 3fiU 4s a 67 Pase
Page 841: wrm95d00
~ FOOD--FLAVORANTS/FLAVORANTS--FOOD - - -~~ 50335 3340 1L T"o of keoeat i Moiee t . Final report 1920-4978 u .. 1his monograph"coritahns a collection of data from the published literature fro 1920 to date. Unpublished data from private industry files are also contained in the gra0h. The,c data cover the specific group of structurally related compounds Oesig the i`itli. Ineluded in this review are data on toxicity and metabolism, usaze and ne R RTf/~ rsrntinne . .. .s _ rpc8rr*e~ WdRa*c*nX tW --- -- -- ~ _ ,... , , _. . .. t _ _. . Flavor Usage .Vo ~ is 1lh4-*od~avo~ + Sw..:,,._-~..,1 3 , . . ` ie»> •~o~ REPORT DOCUtdENTATION J :aEVORT NO. I_. ~rs~N~'1 PAGE F'jlA/BF-79/100 7 iti j.~ ~'~ ~. tkle ~~A tu0tkle !. MOeR D.I. 083 Scientific LiterattFrh.Rey,iew of Miseellaneous itrogen Compounds in March 1979 1179 DCAV 7.IwMoK.1 p~D s. -.rtonnft o.uniz,ee«, «.w,. and Aea..ss FEMA (Flavor & Extract-Vanufactnrers Assoc. of the U.S. 900 17th Street Washington, D.C. 20006 FDA 200 C Street. SW9 Washington, D.C. 20204
Page 842: wrm95d00
50335 3356 ONN WOVIT D~MENI'ATI~ lM%M*ws oa r.w.. N..» W...as. Inforaatics, Inc. • - 6011 Bxecutive Boulavard Aockville, tD 20852 ts ta~+..w M.» w 116..F..M lbod and Drug Adsiniatration 200 C St. SW. Washington, D.C. 20204 s ..1• l ~. .K. . . .. •- .. ..~.,:. ,. _ s M.e.+.or. Aces,w u*. i 3 April 21, 1978 a .ww.rA . M ...j.ai*a.uww. wu N. t1. c«Mr.wrip «c.a.MW Ma w -223-76-2001 IG; Ja. rr...+ s.r«+ a ...r." c.ft.w Tba tiono8raph summari:es the available scientific literature from 1920 to 1978 t~thhs~tyyt ~za~, b~riCacid and brates. Cheaical inforsation, b logi daNt, d 6'Lod~eaiL~ai ~p~ts of them compounds ia contained in a 107 page summary containing 470 references. _" =-,r- -- - - - -. -
Page 843: wrm95d00
50335 3357 t& T1Mo w srM.w • 7IXMLC5-79 ~• ( MoDOjraph on~lslt E;tract FLAVORANTS--FOOD/ k MEPOWT Mo. REPORT DOCUMENTATION PAc.E 1 FWsF-7s/140 P. "'"..W 6000 Facecutive Boulevard ~ Rockville, M 20852 I Infor.atica Inc. U sMwwtwa as•"I+sti.w N.nw .M M&as .*Ar Food and Drug Administration 7 200 C. St. S.W. Washington, D.C. 20204 ~~ Zst ip«ea.ft.ry ts• Ar~ arnft-too ...rq, ~ . ~ 0 ~ ~ ~ S v •~/ h ~fneaa ite ti f4w s the a bl e wet ila t gr / Ld71 7n8 0 s s...A o." Februarf 22, 1978 a a ..rwwdK o0.,4+..aM ...L 76-1926-018 ia ..a.aRKrro... tl. C.+NSUa v C.aweW N.. 04 FDA 223-76-2001 ss~ - SS. TOO MMMRah.i.ICM." Final 1920-1978 14..r..- s-- -Inen Inve
Page 844: wrm95d00
~,,;,,,,~;~ ~itnti~ce Aevie~ot#~ in Ftavor. IIsage . vo1. T[~rd~d~C o u~nary, a es,of DaCat Biblio~raphy . ,. . 9MOh. Zhud d9ta cover ttrn speMfie poop ot struetucally related cozapound4 designated ia the.ttt* bnqit ftd !n, thft revieN .ce data = toxieity and metabolism, usage and natural I ~yTd~i'~miaAOgtaph cionUins s aotleatfan of data froaa't•he publlshed literature frorri` IOZ O to dato.: UaqmS)lishedvdett,a from private•{ndustry files are• also contained in the mcno-- D.~ tAft,,MUL-wh ~~ caticas: 'lttis is a 490 page review containmg .
Page 845: wrm95d00
50335 3359 NNW GRAS(GENERALLY RECOGNIZF.D AS SAFE)/ [tllst.luGF.ArHIG JA7A 1, ecp.nt Ko. $1/1:1' T y~ rf"VBr•-77/E2 A. 1 rr!,,r.! S !.•i!Ie ... ~ 2. ):valcatiua of the licalth Aspects of`/Adipic Acid rlc a Food Iu,-.recSicnt 7. Aut!:'oc(•) 9. 1'rrfo::,n•r :.ni: ati.rn N.arr:c nnd Address Life Scien ccs tesc•arch Office Fcderation of Ar:erican Societies for Experimental Biology 9650 Iicckville I'ike Bcthesdm, :tll 20014 12. nNa+oc «nS Address u.s. rood and DruE, Advtinistration 200 "C" St. S.W. k'ashir.f;.on, D.C. 20204 M5. Supp.c:. cn!ary ;Cotcs 16. A(ystr..cts 3. ltrcipirnt's A S. rrl.urt uote 1976 ccrc.ivn hu. 8. 1'crlnrnru,F Urr,a-iisativn Fcpt. No. SCOhS-F.0 10. 1'rojcct/Task!a'ork Ur.it No. 11. Cuntract/Grrnt Nn. FDA 223-75-2004 13. 1•ype 4L.t Krpt.rt & 1'criod Corercd Final - 1920-1976 14. This rcport, by. a t;roup of qualified scient-ists designated the Select CorVtittee on GRAS Su'sstances.(SCCGS), providc!s an independent eva]uation on the safety of Ad&ic~:cie i»ffouA at0itg~prd~en~or~ro~cted level of use. ! ~ , : c r A . _.•;
Page 846: wrm95d00
S033S 3363 FLAVORANTS--TOXICITY '7IIIF11 u6t u EM • ientific terature Review of vkliphatic Primary ~ Aldehydes, ters and Acids in Flavor Usage (Supplement 2) A NrLos(r ) . Pectorsios Or+aniz.tioo Nuee amd Addres. - Flavor and Extract Manufacturers' of the United States 900 17th Street, NW Waahington, DC 20006 12. 0 cohols, 7. ipicrx'An a_ ti'L..~~.I epont J ate January, 1977~ ti 6. Per(oaning orsanization Re No. 10. Ptoject/Taslt/Totlt Uoic No 11. Coauaet/Graae No. 223-74-2224 ;poasocio= Orssnizstioe Name snd Addtes• 13. Type of Repoa tt Period U.S. Food and Drug Administration Co.eted 200 "C" Street, NW Final - 1920 to 1977 uashington, DC 20204 1L , ~ The Scientific Literature Review summarizes the available scientific-literature from 19J0 to 1977 related to the safety of aliphatic primary alcohols,'•ai-de,hydes, esters nd acids in flavor usage. Chemical information, biological data, and btochen~cal aapects of these compounds are given in a 15 page summary containing ' • 7 references.. _ ,_- - ----=--- - . . : , ~- ...~,.., ~ 050.0'00256.5 •'2 . . . 0 Association r
Page 847: wrm95d00
- ~. -- - 2sICROCRYSTALLINE CELLUI,OSE/METHYL CELLUTASE/CARBOXYMFTHYL CBLLULASEi SODIUkf CARBOXYMETHYL CELLULOSE/HYDROXYPROPYLMETHYL CELLULOSE CELLULOSE ACETATE/ ' GRAS(GENERALLY RECOGNIZED AS SAFE)/ rr.r- t F114/Bg 78 7 uea L9llil/ M ~ MeC_- it .. S.p. ~ ~ E,raluation of the Health Aspects of Cellulose and Certain Cellul6ee-Derivatives as Food Ingredients i • . . EAahoc(s) ~Pertorsaiat prsanisstioa Naine and Address '' Life Sciences Research Office ~'.r.ederation of American Societies for Experimental Biology 9650 Rockville Pike Keport usts Nov, 1974 •. Peitormina Qrjanisation Rept. No.SCOGS-25 10. Project/Tas1c/Worlr Unit Nfo. 11. Coatrsct/Graru No. . FDA 72-85 1 Spoosai.~ ~a.a~jstion Name and Address , 13. -Type of_ Repocc & Period _ 200 C Street S.Y. L Suppkaestarr Notes I Final• - 1920-date i m andbrug ns rat~ A t %.o.etea I Food i i t d Washington, D.C. 20204..., This document supercedes PB 238-793/AS' This report, by a group of qualified scientists designated the Select Committee on GRAS Substances (SCOGS), provides an independent evaluation of the safety of pe1~u;Qse,~nc~„cegci~ 84,~lt~oskde~iv~i~s, when used in foods at present or ro c~ed`3F deFr v6~ j7 ~ p~ i was completed December 1973 ts (supplemented by a 2 page addendum. I
Page 848: wrm95d00
50335 3366 0 . .1 _......___. 0 : .r._' 6RAS(6ENERALLY RECdGNIZED AS SAFE)/ ~ ----._ .. _ ._ -, ---- _ TP ~ 29Y 3117 Scientific liter ture Keview of 983 - 19 9 SVbstltut@d yrazines in Flavor ~ Usage. Second Supplement April 1971 ftavor ond Extract Manufacturers' Association of the United States, Washinston, DC Perforsed and Prepared for the : } +'(,S, Food and Drus Adainistratioa, Department of Health, Bducation and Nelfar. '. 0 O*V 06050 oF coMMacE Moesl Ttchnicul tniomtion Serria
Page 849: wrm95d00
50335 3367 . ru+taI aM 't~"* "` • ~ t ~ I rn~r~ ~f&a lrq1 luDstit.rtsd fti.wtltls }=t;ratars as -0, r.4~a•.•+--• -•-----s--- . . . . . . . . .. M~ ~ . ~ - ~ toa flavor and -Extract Manu,facturel "o i7t. an.t As s a c i a.t Jo n of t he ""'s'm••, D.cU n~00t ead sta te s' 0 : : mta ~onoSrapA coataias a t4isetisa of iaa lsom the pdIL lit.rstYSO ha. 1920 to date. Obpub2iaMf data lro. friwt• f sdustq tilsa ars aiso eoataiaad is tso aioeoirapie. '!haas bta tore= the specific peu~ at stsveturally miitea cd.poands ksipsstsA is the titl.o. Included Is this ss.iw .rs tate s toxicity sad ..tsDoliss, sap aad sattiral. - .ec.rrsace ts toods, and eo:positiona2 opeeilicatiaat. lfia.is a 74 . NN ' r..iar eostaisiu= K rstoaacos. -- :. i 5 0 _~i rEa+r+cac SOMM aL ~`'~ ~O&MIS r.,... ...,.. ~ . ~.- _. ___ 0 oo2 5 6 5 6 -----~+~- ---
Page 850: wrm95d00
50335 3369 ._ TP 983 F1 ~975 i : ~ 0 0 so MSlIOitAr1MC oATa fNtST jIr qi 4 • . lCIZiRItIC Ti?Rt 1CYIIY~ 00 Lt 40 ( ) l00p ISMif I?OA f~1~ Y.~ ! IDi MD REIIT~D.XOi, i ~ i.. •~s.. w.. ~ 71a.s W Octr.et mYrtaettirtts' d~s... of tl;v.0. 900 Utb itroot, w1 , Uaatla0toa, DC t000i `. . ~s i."D«i.ft a..i.ui.. w...r a.r... O.=. lbod a.d Drug Ad.iatatratioa 200 "G" ftroot, w/ a.as..*.o., oc totm tf, i.ppk...ue, «.ra .o1a.a 1 of I Vb1u.os AM~.A W 13. ii. ta 73-162 11 TC~~ R.pw ae fiaal-1f50 to 1975 1. r.S, DEPARTMENT OF COMMERCE " Mational Todnitat Iniornitbn Sesrka : !1! kioatiiie Litesntare tswiwr suarsiss tso anilallo seientifie 1itesatma tsa. 1950 to 1975 ralatad to t!o .at.ty ot 303 qatbatie tla.os .ubotaae.o wod as lood iasr.dioat.. !b. .aD.tase.a aro o.laetod irom aliy6atie psiasT aleibolt, o1doL7d.s, acida, d rolatot aetss. tLa ra.ier .immarisaa the natural oeeuss.stt, .oa=:, csa.ieal, aad liolotieal data oz the .ubataaeoa ia a 3,457 p.=e re.iar eootaiaioj 10,064 sotor.aesa. 0 p 0 2 3 6 5 g
Page 851: wrm95d00
' 50335 336• 94M1A 1YA.iAWUlU JI{YNYIY\IrlVli IA77YNYIIYM we IM• flaflod Slotos, WasAiasloa, DC . . , ; 'flas sa ~ a~ulkae of dtsI Ttro cs " ~ Ittr~e ~o[er~1- tatn a t( tMvub - - -- - -- -~-- . - - ---- _ __ - - ------------~&~t.q ZM SW(sMMur REtoc•ntzEo AS sAn)/;FtAYORMTS ' ~'- - 3~~ enti Wraturs Re w o~~-lip tk Primary •AkohoTs,AtdehYdes„ers and Xdds in Ffavor, "3 ' n 197' usaQ.. ftfth Suppiem.nt •-- .- - -- --- . s n~.-- --~ M._•--- ••--- •--• ----' •--- •--• - -• -~ Ytaettues from IflO to dtte. VV~lishtd dta from petvata ir-0wtey tit46 a» afso eontainN in tAa Sonot rapA. 711400 dta eanr tM qscUla p~a~p arstruetunlly relatb eonipowfds Qssi~tsd in tM tlUa. heludsd M We revlaw we tlsta ak todelty and mKaDotbin, unp snd natural 4aerereaco to foods, and eompadttand spselfkaUoas. 'iLis Is a s*par reYiaw ooata6ft 12 eetasasr. •.s. KPAtTME6T OF 0311MEKE biiwl TicMial Idtmtios 9mios -624i 383 t}~oo0 0 2 5 aS~
Page 852: wrm95d00
50335 3377 74 X T.e ..' PYRIDINE/TOBACCO--PYRIDINE ZlIC SIZ7RING AND HEALTH/ ~ ~ COIAW TOBACCO--PHAR.`tACOLOGY/ • RJR CLASS NO. PAlIPHLET 74 X Le Leslie, C. B. ; Hanahoe, T. H. P. ; Ireson, J. D. ; Stursean, G. (North East London Polytechnic, Dep. Appi. Biol., Stratford, Gt. SOtiE PHARMACOLOGICAL PROPERTIES OF PYRIDINE. Pharsacol. Res. Commun. 45 (No. 4) 341-65 (1973) (in English) *Keywords:* nicotine. *1974, No. 23, W 8827* *d* Tobacco ucdieinas . . ..~~T..Y. . ...-~~~.,....~~ ~-_tT~ ;T . - , T .• . ! • . . ' . .~ .. - ' , . 5 0 0 0 A 2.5..6 6 6 f nrit.) ~
Page 853: wrm95d00
' 72 II Ns 50335 3380 YREpfS--TOxICI4T/ - / NHAL~1TI01t/ AltIMALS=-:'GXICOLO(iZ/LQ1~S-+-IIiHALED PARTICUTATES/ • OXYGEN DIFLUORIDE/HYDROGEN FLUORIDE/lLUORIDE/METHYLISOBITfYLRETONE/ MONOlB'TtiYIUDRAZINEMDRAZINE `AD 714 694 TOXIC HAZARDS RESEARCH UNIT ANNUAL TECHNICAL REPORT: J. D. MaeBwea, et al S7stemed Corporation _ Daytoa, Ohio Ansust 1970 r Wl?IOALIL TECHNICAL 1hF0icYAT1QY SERVICE .... . ... ... •. . ; , .- -- --- 5 ' ` - •-- ..~ ,r 1970. irs.:crARTrirT oF Co1fYCIlCc - ,. . . ~ /.s::•' - ..._~
Page 854: wrm95d00
FLAVORANTS AROMATIC HYDROCARBONS/' 6RAS(GEIIERALLY RECOGt4IZED AS SAFE)/M 50335 3366 n ~ i; n L ~ Scientific literature Review of Aromatic HydrocaiDons in rinal report Flavor Uso9e. Volume 1. Introdudion and Summary Tabtes of Data, BibYio9roPf%y lit 1 r r_ .. . , , . . . . ~~ . ... • :.i .. . . ~ I ~ . . ~ . .' t. . . . ~ S.• .. . . . . : Uhited 5tates ilavor, and..ExLraCt .Mlaijlufacturers' *Association of t~e-- 4'~' ._ ;rl.a~ ri97f~ AV... sL Nr.. MIAM* «...".o !W saa=rapb contains a collection of data trom the published literature froo 1920 to date. Obpublished data trom private industsy tiI*s ara also contained ia the monoSTap6. Zt.esa data cover tM apeci[ie -=roup of strYctaraup related coepounds desitnated is ths title. Included "ta this review are data on toxicity and swtaboliss, usate ard natural . oetnneaea is toods, and co.positioaal specifications. Tbis,is a 1a3. pata saniaw toataisias 709 reter.ncas. . . . : ~' ~ ~ sR~ee.on w I~ f T' . NA~.a ~*~Setv1C! 0 5 0 O 0 02 S6 8 5 .,
Page 855: wrm95d00
0335 336 _... _ ...-~,-~. - 6RIlS(6ENEVN.LV 1&C06+RZED AS S11FE)/ FLA1fORANTS ,."u RtrORt OoCJYCMfAt10M ;4Wwiw .a POW ...__~._ . J . .... ...... *=t1tla LKanture 1t.ritw et~te~elta E7saipo~~ oi C1ubaa, ~.a and Qacy~.n b tia.ae tbe - l~o~rtl~ Suppla~s.at _ "ITa or and Eitract Manufacturers' AssQci ' ` ' " IL Nam» ~~ o#' £~ti e Ztnft,ea States f "O"ru"k, wahkatoo. O . .. -~s. -.w...+.~..~ IL AylO _;. © twlaw aaatainUv !f reAteno4r. s aeaw"W. ta taoM, ana Qompadtlaad y.alAeatioas. '1bb b a!s<p.p ~8~~f6'3$S • .......,.. tfon Y& aAea/!7 M Mwtlb /1a @GU44-nK titiMA~wAthr+wO.ww~ ~ !N C slcwt,DC'!D!!t ` , [l~.3_a[~ocst IltO-tttt -- - ~~.awle.pA ionlalae a aoli.ettau at dita Qoin ltw pub1t.Ab j.' *Unfta ftm 1!!4 to dta. Unp*St1»a erta ttoe pAwta bdnstry f'da we ato aontatnM M " 7A.ra bta .ar.r ft "fAe ~~p d ~trartw~ tNatad ~Qa~i~nat.0 Y tM titla. Itieluded i~ ttcL r"Iew ars data aU to"y Nd ~etabatt~ay m.Ca and eaturd 1.1 OUMTMENT Oi cOMMEKE . - ~--- -- b!>rn~I T~cWc~ll.bn.~t~ S.nb +~5p4QQ2 56St~ ,
Page 856: wrm95d00
IL-fLqypRqNTSaA(rE~ro LY RECO(IMI2E0 AS SAFE)/ enti~k Literatur. Review of~Afiphatit t // • `t B 9 8 o~th.rs In flavor Vso9e. Yotvn~t i. tntroduction on~d -• Tobie: of Ooto dibl'wmro Summary ,,, h -- - , . p ,,r,a,,,~,,,,,,,, y ,. Tt .. fhrot aid Extrod Mandfocturon' Rssoctotion of tM IWt.1 Stots, Woshinptoe, K ~ . .. , • . . . ' . • .. ~•''I~ • . -. • ibta f~wOra eo~ntaiaa a eollset .!' 4ta rsa the publishN literaWrs tse. 1 20 to date. Oaputilishad data free private indwtq ii1M aca alM tantaiaad is the 8oasOtsa. lAas• "ta cover tLa specific •; Ora* at athet.=ally relatad eemporels dssipsatd ta tba title. Iweltidad . ts tUis tevis+w ars data sa toxicity ad sstaDoiis., sa&a aud satnral . .cesreaee is leiQs, ama eospositioaal spetilicatieaa. lfis. is a Oo . pata se.iar e..taiataslos ce[ac.ness. . . I .
Page 857: wrm95d00
50335 3376 I ASSESSING TOXIC EFFECTS OF ENVIRONMENTAL POLLUTANTS edhed by I S.D.Lff Research Toxicologist Emironntental Criteria and Assessment Office U-% Environmentat Protection Agency Cir.r3eoat{, Ohio I RA 1231 Le 1979 • • - • • ; ' Y • j. BRIAN MUDD I hofessa of siochemistry Universiry of California. Rirenide 4 g 0'0 [~ O? S 6 b S . . ., )ANN ARBOR SCl ENCE 1 .. : . t1I?ROGEN AXIDES/AIA--POLLUTInN--HEALTII. EFFECT/ TO8ACC0--S?$4KINC--IIF.ALTH EFFECT/O2O`tE/SULFUR ACID AEROSOLS/ /AUf()MBILB EXHAUSE/SUT.FUR DIOXIDES! Ml1TAGENICITY (Air Pollutants)/ SMOKING AND HEALTH/
Page 858: wrm95d00
~a „ . _ I::SECTICIDES--TOXICOLOGY/ J.A. Lofgren, DM. Noetzel, P.K Harein_and LK.Cutkom p __ ~ Insecticites and Their Uses in I';~inneseta- UNIVERSITY OF AAINNESOTAsion Bulletin 263 Revised AGRICULTURAL EXTENSION SERVICE J P; `est ~. . 0 5 ~ 0 n 0 2 5 6.6 8
Page 859: wrm95d00
0 •..: „ eM(sEWRUw RECOGNIZED AS sAFE) , r fLAVORANTS/` .. in Suenmary, Tables of Datq, and e'bfioRropk . Re.°wt .. . • Ilr : fiovor .nd Extrod Manufoctnrers' Assrdatioe .t tAs dott.d Stht -- ~ - _ e. - Aueuit M7t WoAlnftok R.C ~ ~ , l1i1ft nor eone,tn.m eoUWUee ot aa tom tAe putaidW utentw iho. /` 1020 t. a.e.. wwe ate reaa p.w.t. "Atrl !ua w d.o.oMsn.a !n tA. umny fektod ; •~s~iSnlt~b k tM _ dtM. U UaWdeA in t~At~~...NW .M daetn tatklty ~nd ~et~. t ..es..n0 n.tur.1 o0eurrOW In food1,.n0 eoapodtionst VeeiriaatioA. Tl~t. r• t 30 pert rev4w aoataWnff !fd `st.nnaM 9e3 Derivatives In Flavor thape. V .. 1. IatrqduNioei and••••10 •y"•w"•••.••• ~ Scientific literotun Review a+d : : `~a2~9G2- :,. , . . '. a&A-. . • its , .aweu w ~_Qpd256S'4NA,. .. .
Page 860: wrm95d00
XX HeC -7R S.P. TANNIC ACID S ~ 61t3L10GRAPHIC DATA ! SHEET FDA/BF-78/15 •. tt le a 5ubt u e ~- S. Report U.:e Ingredient Evaluation of the Health Aspects of Tannic Acid as a Food , 1977 9. Pertorning Organization Name and Address i Life Sciences Research Office ~ Federation of American Societies for Experimental'Biology : 9650 Rockville Pike ; Bethesda, MD 20014 , • i1Z Spoasorina Oraanizstion Name and Address ; Food and Drug Administration = 200 C Street, S.W. 1 Washington, D.C. 20204 , nrl 1. Report No. ' a e 8. Pe:tonning Otgsnisatioo Rept. No. SCQ6S-48 10. Project/Task/Work Uoit No. 13. Type ot Repocc 8 Period Covered Final 1920 to 1977 al~ scientists designated the Select Committee
Page 861: wrm95d00
+--- sius(seMFnuLr REcosNItEO AS sAFE)/ PLAYORANTS TP 983 n 197 t c ~ t .netr~RYMK MTA 1Lt!-~A3-~/[~laal l:4..1 klr ' f, 940- o... (iupPle nated tclDrrlnc LI?LRAtObt WIlY6 OM a1RbALLT RLOOarIZID DILt'[: - 6LIT1A?1C tlI11Ai! AS iATS (fiAf) T000 IUfSO ~ A1.COIiOts ALDE1RDEf ACIDS "" ..Iw.i.. a..w.d.. R.M. . .. s On..i.ui.. M.a« ..+ adr... t.. r..j.edT.,!/t.b u.it M.. na.or and Ixtract li,autact.rers* bsa. .t tbs O.s. !00 17tb kreet, W iishiagto., DC 20006 il 6....riy Ora..4-i.. p....d ANw.. U.S. Food and Drug /1d.iaistratiw 200 mC" Street, !Y Yaahiaitoa, DC 20204 Iis.rk...m'M... rolw 2_o! 7 .olu..s • t. u...R a.. !D6 73-162 u. TY".t R.r" a n»1 c.-...~ Tinal-1lSO to 1!7! 11, 11 DEPARTMENT pi COMMERCE Nsftasl Uthial l.hnsatiss 3sria ! tb. Aka.es. !fa Scientific Literature Mrieu a+s•arises the available srisatitie literatare lra. 2950 to 1975 related to the safety of 303 syetb.tie flavor substances used as food tagredieuta. Tbe substaucaa are selected irom alipbatie prisnry ,0 0 5 ; 0; al~bo~al}b2s, ~cid5 a4relatsd estersS The re.iev su..arisas the ,~jra e~ca ,,~, e, eMlieal, and biolo ical data aa the substances, ia a 2,457 page re.iev eontaiaiql 10,064 refereaeea.
Page 862: wrm95d00
CR/lS(6ENERAll7 RECOGNIZED AS SAFE TP 3 9a3 s ~ r F1 1974 , i f ! Nq6~iNt 4ATa K•. POL - ." - , PB25l~77 ~ e_ :k.r.sa.w. PPP??P d iClWIiPIC LIlGtCNNL RYINIR a CDIDtAIi.: V Asl 1974 Dsc. 1975) ~t ccRAS) ~OOD n~alt3nlarrs =sru~rsc t!t]u~+11tT , w~~mas KC1DS ~um sta I1r siJ~ tK/i0i. • i7r7u= iol~.a ,;,. , w. •. ..t«.;.. .isu;.. w« .d Aai... N. P..i.a/T..lR.A u.M H.. Tla.or aad tatract 1Lmdactosors• 4ssa. of tNs U.s. 900 17th itre.t, Ui L N,, YaaainStao, DC 20004 Is ip..«is orp.lmi.s w...r A~e.. l.1. tool aad Drv4 Id.isiatratlea 200 %'" arsst, W wsniastos, Dc io201 li f.Mie..w.y N... folum 4 oi 7 volasiss. 1L =Ap.n a Paf.i ?isal-19l0 to 1973 14 •s DEPATMENT OF COWRERCE Ibtiwt T.dMktt MfK.yllr Senia W .r«". i Tbe =cientitic Literature Se.iwr ou..ariseo the a.aiLblo scientific literature ; iro. 1930 to 1975 relatsd to tUs wtetP of 303 qntbatie flavor substancu used O L+ rts ~pd ~r~: ~a ~bst*oeas are seleetad irow alipAatic prisiar7 .~ }41e~1.jlal d ds~ad4elated esters. Tbe redew ous,arises the natural : occurr.nce, asap, cbeeical, a'd biological data se the snDstaaces is+ a 2457 -:i.e .:vtw eontainin^ 10,064 xeterencas.
Page 863: wrm95d00
sMS(GEMEaa.i.r RECOGNIZED AS sAFE)I . FfavclRltM" f~ K TP1 T~ r ~r .d sa.ww 983 kALLT fc ITIC .~ Ms fEVltii! oX R t~ ao mz! . ro vruwnl ~~ ( ~ ~a~m Es . . nu .~m tisatac Mlft ~ 197 a~wwc eat. tDJ~3 ' ~ fn.) ~ 407. ~ a.1~e o,w tw L !fp 7 1l76 psc. is7s) l~nwQ nr stAVat • n.a _ c ~ a,, ~ ~ ..d.~.is . s.~:.. w....+ ANn.. F ls. ..ti ..~ u.« ~+. 11a.or and ~tsaet Uasututasosa• 4aa. ot t1a II .l. ftsoet, ~li !00 17th M.. t. C..n.a ~~ ilasbia~tos. DC , 20204 ~ 73-162 11 fp.awiy ap.is.ri..lia....d wAIqrw lt r~~ Rq.e a.r' 0.l. lood asd Drq 6d.iaistrstias 200 "C•' ftrest; fit •, pinal-19S0 to 1975 Yasbit+lton, DC 20204 t~ ts. f~Mrwe~ ww toli.e of 7 IIol~es tt. abu,.au The fcieatiiic Literatore fe.iar au~arises the available acieatitic literature iro. 1l30 to 1475 related to ttie aatety of 303 spntbetie flavor substances aad as food talredients. The substances are selected tsoe alipbatie psiaary • alcobols; aldehydea, atids, and related astera. Tbe re.iav wi.srises the natural occureaee, usage, cheaical, aad biololical data on the aabataaca is a 2,4S7.paje seviw containinf 10,064 seferaaw. ~!. oVAIl11lENT1F ~1lYQtE 6 0 fatioa~l Ttch.hal idans:tioe Sariq
Page 864: wrm95d00
:.-f-.* ~vt .'~- '~.~~~ • f0fi 6 .. _ 50335 3341 POISbn--T01CIeOLOGY/CANCER--CAUSATIO[t^SY LNVIRONFBtTrAL PACTORS/ CANCEB--CEOGRAPHICAL/CANCER--CAUSATION BY CBEMICALS/NITROSA?l2NES/ RUG ABt3SE/I'fITRITES/NITRATBS/ ettceTIN U WAt gLMgTKa earn ; J3HATmY.. ,-- TOBACC~~~KINC--HEALTH EFFECT/ 1'9 Advances in Modern- Toxicology ' , 19 !~e VOLUME1 1979 , f fIVEw CONCEPTS AFETY EVALUATION • Part 2 BDITED BY MYRON A. MLHUMAN MEDICAL DEPART6IENT, MOBIL OIL CORPORA7IOH 0 HEMISPHERE PUBLISHING CORPORATION Washington , Ncw York Loado RAYMOND E. SHAPIRO NA770NAL INSTITtfT6 OF ENVlkON6fEIVTAL HEALTH SCIENCES • • HERBERT DLU111ENTHAL FOOD AND DRUG ADMINISTRATION s67o osooo.a2 A HALSTF:D PRESS BOOK JOHN WILEY & SONS Gh;chcstcr Brisbane 0
Page 865: wrm95d00
50335 3384 r r, • R"T OOCUNENTATION m" t ' k~A"r ~- III Iie -79 .~.g' lbeas rapb on~_,rn 11 _nt Oil . 7. OAMWW Robert Rossra ~ IL PWUMwM oM&++•«« wm. «. s.w«. Inforasatics Inc. 6000 6cecutive Donlevard Ibckville, M1 20852 1s frwtir/mg o.fWNw Mawe swr Aldrss P-121N 446 a vew.~.. o....i..M« sy.a N.. ~ 76-1926-022 Oa Pwi«yr.w1wrM ww N.. ll. C.w.eMa.Q e•+N1U N.• /4 223-76-2001 M p.ti..as....~ar.a..t...... Food and Drug Ad.inistration Final 1920-1978 200 C St. S.li. K, Washington, D.C.- 20204 . TA.°1lonograph auwaarises the available sciestific literature fton 1920 to 1978 related to the safety of Corn Mint Oil. Chesical infor.ation, biolosical data, and biocheoical aspects of this co.pouod are aiven ia a 36 pa![e smaary containing 92 a VeVO 0 0 2 $673 •
Page 866: wrm95d00
Range-r lndiIlg Toxicity Data: List VI HENRY F. SMYTN, JR., PF.D, CHARLES P. CARPENTER, Ph.D., CARROL S. `YEIL, M.A., URBANO C. P0ZZANt, \i.S., and JEAN. A. ST1iIEGEL, B.S. Me!!on Institult of Industrinl lttstarch, Pirtsburgh, Pcnnsyhania (~ A table prescnis acute toxicity and i;ritation data on iaore than 300 compounds, accumulated i;i a coniinuing pro;mnt for screenin; potentiat eomnercial produets. The standardized c:cncriiucntat nuthods :.re dacribcd. ,,;m;..,. tt,,, arc ,briefi . • . Y____.
Page 867: wrm95d00
Editors: Charles Wm. Sharp, Ph.D. Mary Lee Brehm, Ph.D. • ~NIDA Research Monograph 15 October 1977 DEPARTMENT OF HEALTH, EDUCATION. AND WELFARE Publie Health Serviu Akohol, Drug Abuse. and Mental Health Adminis!ration National Institute on Drug Abuse Dlvisbn of Research 560f) Fishers Lane ' . • Rockvilks, Maryland 20857 050000 256. 7 4 r RTTf: ARnSF,/P~TfZ4T,hTTf1'J/Tn'{TrnT.rN'Y--T'dFTAT 4TTA'iJ/'. __ /S(1LVF.*1TS--HFAT.TIi HAlART)S/ TM - Revienv of Inhafants: ~ Euphooria to Dy; funCtion 1977
Page 868: wrm95d00
! "Nn UA"PeIN R~l§tXl.~ ~3wWO~ d6 tUrlYrM 1', ' •saasz.3s= t90sat ~Ts=soa wsj.u sfsd titt • nT aausasqn. .q7 se *isf TWJTSoToTq p" 'T**in4~ `Nsw •.aossnax Texasw sqa ws=a...ns wst..a .qL •sssas. p»*TSt tw `@pfas 'pptqepTs 'stsqCM Ls..jsa afs.qdTr .osj ps*sT.9 w. ..vansqa. .u •ns.Z}slaf .ooj .M pssn ssamasqe. sa..v sTasRs"o tOC fe As*1" Rs av Ns.T.a Stit q QLtt u"f ssu.as1TT *TjUasja. •Tq*IT*As •q3 safs.WWs A._..2 ssu3ssn OtffsUPf" OU ' ~" 7l tLtt 03 OSR-t*aTt .W+a • Us"s =1 tt LlM" Tat . st f.q ..u=..! acst •Ma +ut Atwt :umsaw, ...o ...I s •r. wES =. • !Y •YiYU w •03ftwu !r '3MS!= w'~r OW r.pssssf~ ~Q P~ WOi 'ra sww.... ...M .~a.,~ ..~....w~ s~ ~ ti, . ~0=Ot ~ 'sos~afl~11 g 'sssas ptt OOi 'wsy .sssW3xjneM sassM 1a. ssr.ti I "UMV PM saw wwb""pri ~ rn IMru Ia min saz 's 3~ `rio.oo~+snhaur~ ua~~a=~~~ss~ fp m~T~oooi~ sn~LlK 'i ~ =' . •.My •4rs.e k//r~001~ iH , === 3! •LfE SEfOS .
Page 869: wrm95d00
INDUSTRIAL HYGIENE/TSRESADLD LIMI? VALUSS(TLV'S)/ /'TORI.CI?'1f---CHEMICAL COMPOUNDS/ Y : 4 .y HAZARDOUS AND TO,"XiC ~ EFFECTS OF II!lDdJSTi R1AL CHEMICALS 43f .~ ' pa v'; ~ Marshall Sittig NOYES DATA CORPORATION Psek Ridg., Nwv Jeney, U.SA. 1979 ~ ,-,-, r o /, ..r ,, _ (, ~ to "I ,. !ti~.-1, _. . ._ _. ~.. yr~ .~ 0 900 0025670
Page 870: wrm95d00
50335 3389 ~ - - - - . ::r. . .~-K.s. : A... -.:4 ; * ANIrtALS--DRUGS--TOXICITY TESTS/C1iEL4ICALS--TOXICOLOGY/,yICOTIVE--TOXICITY/ EfFECTL . w ---~--- ----- g ;/pE g~~Igg_T C~ T ENVIROOL~ON ~i!iTR~LD RF.SC~i ~'I:RIES 18010DPV12/70 897 Un W~ter Quality Criteria Data Book, Vol. 1 1970 ORGANIC CHB4ICAL POLLUTION OF FRESHFIATIIt s- for the U. S . ENVIRONtitENTAL PROTECTION AGIIdCY Water Quality Office prepared by ARTHUR D. LITTLE, INC. . CAMRIDGE, MA3SACHUSEITS Project #18010 DPV Contract # 14-12-538 December 1970 ~04 I/, `S
Page 871: wrm95d00
' ~M+tS MI~PI R~lR„11~l~h 4'~"'~'~u°~"'0 •wass.jas MObT ~T~Tssiw ..T~s a.i ttK s sT p3OW3•ww oVa so nR TnTSDIeTt rm 'TWTwIP '~Ms •1iWuiADSw Tt203Nt iQa nsTIWMWM A1Pf1 OU •0ISa" MWTM we '0" •M~~jq ~ l a oa d 3. s s 's o La.w aa es 3. WS ' A T p µ t T q q s w a" qL aT to* w TP S W3 6aNTps ps.a so..as4a. tow.Tt sT3paaL. COC 10 L3.j.. .ii es N3KgA. LLLL A OCLt !wi . s.m3s13Tt ~ffT3wTw •Ii~IT•t! pa qsjil~ls Aij11q sttisil3n .~jjiOSj>: i~,. ' . YI ~+~IM t f~ L ~IO~ H fOLOt N '.otftRM . ttLT w aLt-twTl r`30"a! w% OOi i ~` ..nssasrTm.v sust .w pact •s•. + +u pond 0 ~..+.. r it io «~w rw «r--.. tfT-tt !u i0L0` ~ ~~ai~aiM~ ' M M 'iwsm sstt 006 •!•a N7 se •~w ssss2qarlnsm ssuwq Tiw sawL wa won w • ~ ," Z ~ x •sORG 10Lfll R fstii ~ ' ~ ' ti.ya~t aI :Zata= ~a (no3 (Slit ' wQ ltit TY ~l900~ fA=IVi DIlISRlT7~ w ADM N riw>Ka11rMOt
Page 872: wrm95d00
50335 f GRAS (GENERALLY RECOGNIZED AS SAFE) FOOD INGREDIENTS - CELLULOSE AND_D_ERIVATIVES ~, }~iat Qrganizstion Name and Address Informatics Inc. 6000 Executive Boulevard Rockville, Maryland s' 12, Sponsocioj Or6snizatjon Name and Addtess - - ~~~: ~ . - _:-::-, . '1b. Absuacts ; : U.S. Food and Drug Administration 200 "C" Street, S.W,' Washington, D.C. 20204 w Distributed By: ~ . DECEMBER 1972 National Technical Information Service U. S. DEPAitTLiialT Of CO','w"JERCE The report summarizes the available scientific literature'from 1920 to 1972, f(2QP--1!DI??~':It~S--~~y3tP.,r1LLY frEC~G:~IZ~n 11S si~~~/ - ~~ . ' . -~ _ _ ..... ~ .. w-..~..~~~....._.y~y.'r.- . . 3391 related to the "safety" of Cellulose'and Derivatives as a food ingredient. Chemical information, biological data, and biochemical aspects of Cellulose and Derivatives are given in a 84 page'summary'containing 494 references. ~ • _ .. . . , . ~ ~
Page 873: wrm95d00
50335 3390 FOOD--ADDITIVES--TOXICOLOGYf .~ XX MeF-D-372-74 ~ GP,AS (~EIVERALLY PECUGNI?ED AS SAFc),PQU Ii1GP,EDIEWITS -- Ah(iUNIUM 1011 PB-221 235 1Z Spossocina Ortanizeiioa N:.s .ad Address . Pet/areiai OtR.aisatioa Name aaa Add[ess - Se Food and Drug Administration ! Ipformatics Inc. '200 "C" Street, S. W. ' -4000 Executive Boulevard Washington, D. C. 20204 - Rockville, Maryland 20852 ~ ~ 16. A st»css The report • summarizes the available scientific literature from 1920 to 1972, related to the "safety" of Ammonium compounds as food ingredients. Chemical information, biological data, and biochemical aspects of ammonium compounds ue given in a 127 page summary contsining over 900 references._. DISTRIBUTED BY; FEBRUARY 10973 ~J.S. DEPART?:E.ti'T OF COMtERCE, NATIONAL TECIINICAL INFORMATION SERVICE 17p ~# A, -:* - • 3 7/ S , : 0 5 tr 0 `0. . Q 2 5 6 7 9
Page 874: wrm95d00
Was Nlits)lM RWMl RaluM 3O IIy100 !0 1M1111Ay1o Y'A •naauslu 190'Ot IMaT*snoa wWTus sloi LtyZ ! .sT aaaeseqM .qa so n9f tnT$otoTt Ta• 'tra=sssp 4019SS 6-iawue330 pznaw sR3 sssTisasnr "Wa OU •uaTrs p039tos PW 'oATr 'pPZq*Pto 'otoR**t* Lau=sQ aT3vqdTtr sosj p9330too .at aaaqoans p,= •osusTPo=hT Mo3 Si pon- woa"eqns aowsT; a=3p3a[9 f0E io Lsorw vp e3 P93Vt64 SL6t 03 0961 WO1) iaw3?iGi-t wTiimpi ilYwLis" n13 aOs}+s~r CwTGia O3R3~I;yTi3T~j=~T~-OrY-- SL6t 01 OS6t-t9Mt =Ot-tL r0i - ~ - - ~ • •sam ia-ru u auvm mnr sai*v •xSL6T wo~yes~oyt aumu~ar - svaia~e~a aoo~ ~~~ u csL~ ~t6t~~ s. CiuooM tnvn= so an= nariusrt aatu= 8LO5Z8d " u =-=w~~ ~ di .n ~iw ~~-esonsw ' Sltri-'bOr'lbr7~.lt~rt s~r aazt~soi3~,,-tt+r~l~u-~)s~ru~ y~ £ t£ E S£ E 0 S
Page 875: wrm95d00
50335 3382 , PYRAZ.INES/THIAZOLES/THIAZOLINES li! Deoc Ar cMOtica soetlooti0C1<, 3h), !+ !-!0 73 X Re -81 atK roaKI>~r eF SELECTED rtA~ cMCMtcks ` r, 1 I.J. Niras, aoe TO1. tasterray, S.P. v4101i:ernat/onal •lavors anA rra9rances, lec, % Ibl.n iead, I/,J. aw !~ rort, M.r., • aaeit.t. Ater. ~ 1A418 fbin" 2196. iorost Mllts, N.r. 11»S u+s1RTM acute oral lethal deses are reporteA In rats or .ice „~,, fos t3 saAstances rhic* are used /o flavorings. yor specific /a'1'/' 1 ~ lra~ps of cerpou~s rhich centain sereral representatives of one ~stwctural class, sem effects of st.rcture on acute oral to.iclty were observed. for oyrazines, the addition and position of methyl groups affected the tox/c/t Mhile the sut+st/tution of ethyl for 4A b wethyl had little effect. Toxicity iecreased with the proxiwity F of the rathyl group. TAe tAiateles and thtatollnes tested had f siMilar toxicit/es relaraless of the side lroups. The furan thlo- I esters tested were about equally tox/c, a fact which would be consistent vltA hyerolysis to the acid plus thiol. /. .. .. • . . r 0 5 0 0 0 02 6 6 7 1
Page 876: wrm95d00
FOVD--.A -DuTT34'ES--GF,:.'~sRAL1,Y -1MCA1tr:;D' AS SAFL J ~ h FOOD---ADDITI VE S--TOYI COIAGY /TOBACCO--lIUMCPA,~ITS /HUMECTANTS / o+ XX MeF-D-372-74 : ~ ~ ~ GRAS (GENERALLY ficCC,NIZLD AS SAFE) FOOD ING:;-DIEfiTS - GLYCEPINE AND GYLCEt;IDES i Rockville, Maryland 30852 The ieport suamariies the available scientific literature fron 1920 to 1972 related to the "safety" of Glycerine and Glycerides as a food ingredient. Chemical inforsatioc, biological data, and bioche=l"l aspects of are given• in a 218 page sunaary containing over 1800 reference! ; PB-ZZ1 227 ' FED BY : DISTRITI! Ui S. DEFARTME'NT OF CO;S-tERCE, NATIONAL TECH2/ICAI. INFORMRTION SERVICE/ ~ .~ ~I . . I . 0 '4O-jtaaitatiea Nase aeQ AC.4eas ' pforaaties Inc. Executive Boulerard iyoasoriea oqu tsacioa \a.:a aod Aaaresa Vt~1. Food and Drug Administratioa 1~0 0FEBRUARY ]~7~ ~ 0 "C Street, S. 1i. Yashington, D. C. 20204 ' .-
Page 877: wrm95d00
II PteA,-76 S.P. 1. REPORT NO. EPA 600/6-75-002 TECHNICAL REPORT DATA _ ~ ~---- - -- ~-- -- _ -- - /Neint nrd IAunrcrionu on rhe nrau Oe/an oaeplr'--a. 4. TITLE. AND SVlTITLE Scientific and Technical Assessment Report on Manganese 7. AUTNORIS) F-PEAFORMINO ORGANIZATION NAME AND ADORESi National Environmental Research Center Office of Research and Development S,E:nvironmental Protection Agency Research Triangle Park, N. C. PB 242 2911 K. RE1O11T OATE ftril 1975 jE,. IERfORMINO OROANIZATION COOE ~. PERFORMING ORGANIZATION REPORT NO. Manganes '`e Transport Pneunonia N pNAL TECHNICAL r ZN-K INFORMATION SERVICE- Ecology Toxicology i This report is a review an evaluation of the current knowledge of manganese in the environment as related to possible deleterious effects on human health and welfare. Sources, distribution, measurement, and control technology are also considered. Manganese is associated xith small particles in the air. Concentrations measured in ambient air averaged 0.1 ug/m3 (annual) with a maximum of 8.3 ug/m3 (annual) near a .~) In Norway, a form of e~ n attributed to airborne manganese 1~In g re~+~~rv~hAe -~,~.....~ .e ~« e~ „~/m3. Manaanese I ' 4L 4
Page 878: wrm95d00
50335 3393 LICORICE/FOOD--ADDITIVES--GI:NERALLY REGARDED AS SAFE/ / FOOD--ADDI TI VES--fiOXI ~O1AGY / 7ot HeF-D-372-74 TOEACCO--ADDITIVES--TOXICOLOCY/ f GRAS (GE~:E~',ALLY RECGG~JIZED AS SAFE) FOOD ItIGREUIENTS ~ GLYCYRRHIZA 7. rc..w..as vss.aaa..vo..cnc .oa namcsi I=. Spowiotlpj 0(`Yltt{las *aAe al1a Addle/s Pn,,,,, 1LL+ , L'SO ,.~` t ~ ' ~,aformatics Inc. Y b000 Executive Boulevard •11,01 Food and Drug Adminiatratic DECEf• ';R 1~~2 00 S . treet, S. W. Rockville, Maryland 20852 Washington, D. C. 20204 The report summarizes the available sciontificyliterature from 197d to 1972, ' related to the "safety" of Glycyrrhiza as a food ingredient. Chbc4ical informatiol biological data, and biochemical aspects of Glycyrrhiza are givea in a 33 page sue~+ary containing 143 references. DISTRIBUTED BY: ~lh- ~ S. DEPARTMEt°f OF COlLMERCE, NATIONAL TECHNICAL INFORMATION SERVICE/ L U' 1 L' 7y 3yc 770,' . •y -.7/ +e~-~----~r,.~--- : --•--~. _ , . ~ .~.- S b 8 2 - O S 0 0 0 02
Page 879: wrm95d00
Spector, William S ed. Handbook of toxicology. Prepared under the direction of the Committee on the HandL•ool: of Iiiolo;icnl Data, Divi- sion of Biology and Agriculture, the National Academy of Sciences, the National Research Council. Philadelphia, Saunders ~.. 28cm Ineiudea bibliographical references. Oorrre:wrs.-v. 1. Acute tozicittes of sol!!ls, liqnids and gases to taboratory anima>s. Vol. II. tintibiotics 1. Tozicology. r. Title. RA1211.562 615.9 56-6976 Library of Congress ` J 158k10,
Page 880: wrm95d00
50335 3 399 . FOOD--ADDITIVES--GENEP,ALLY'REGARDED AS SAFE/ /FOOD--ADDITI%'ES--TO:{IC0L0GY/ -7p( HeF-D-372-74 GRAS (GENERALLY RECOGNIZED AS SAFE) FOOD INGREDIENTS: SORBITOL 9. Petfocsias (hdanisatioa lLae aad Addre.. lj Spaoso.ie Or :a~suioa Kasa aad Addr a Mforoatics Inc. ~liS. Food and Drug Administration l %b00 Executive Boulevard ~100 "C" Street, S. V. pUGUST 19~2 Aockville, Maryland 20852 Washington, D. C. 20204 Utstributed By: U. S. D'cPARTi .EilT OF CG:.::,;tt;CE Nstional TEch;;;al Infornatinn S^rd;,e •The report . suce+arizas the available scientific literature from 1920 to 1972, related to the "safety" of Aorbitol as a food ingre4ient. Chemical information, biological data, and biochemical aspects of )Sorbitol are given in a 88 page summary containing 926 references;'.. i ~ Y . ~ . / . ~ . 3 I o 5 0 0 n 0 2 56 8 3
Page 881: wrm95d00
GRASO-ENEIW,LY RECOGtiIZEb AS SAFE (FOOD--INGI}ED4BN'i`9L ~ SCIENTIFIC LITERATURE REVIEWS OM 6EdERALLY REWI2ED 319 030 SAFE f(QRAS) F00~ It~REDjE~NTS,AAL.~IE PB-223 846 , gAparytiq inc. IJ.S.'~Dep4irtsent ltealth, Lducation & Welfare, L 60M Executive Boulevard 'Food-atO Drag Adainistration, _. : tarleville, pZYtwnrt 2naS2 idashinftOn, D. C. r. S• DETARTUENT Of CKWERCE • i Mftad Tt.cc6Aicd htormata Serrice ~' ~:. ~+ MAY 1973 !he Scientific Literature Reviev susssarises the available scientific literature from 1920 to 1973 related to the safety of Algae as a food ingredient. Chemical informatioa, biological data, and bio'"cheaical aspects of Algae are given in a• 27 page swsary containing 193 refereaces. . ~ } t I
Page 882: wrm95d00
50335 3395 61tAS (GENE1tALL7 RECOGNI2ED AS SAFE) ~~ - -• FOOD--IIIGREDIEN?S/ .... • ®sB 227 SCIENTIFIC LITERATURE REVIEWS ON GENERALLY pa-2z3 $47 i~ RECOGNIZED AS SAFE (GRAS) FOOD INGREDIENTS, ~Y 1973 ~ i•: ~- ACONITIC ACID Sponsortna Organization: "dMu. Dept: Realth, Education, & Welfare. ~ and Drug Adsinistration' • • 200 "C" Street, S. W.. Washington, D.C. y ors~stics Inc. ~oo facecutivs soals.ard t~,,~. DEPARTaIENT OF CO~~i,~ERCE ~ toe Gi12e,~l~g~1aU,_, z0ssz )ta~ctal Techaical tnior~ation Service , . . ~ ~~. ~ ~ } '11,1a Sa~estific Ltteratore Review suamarises the available scieutific literature { irost 1920 to 1973 related to the safety of /4conitic Acid as a food ingredient. CbeaicaZ inforsation, biological data, and bi6lchenical aspects of Xconitic Aeid are given in a 23 page summary containin= 79 references_ ~. ~ . . . ~ 1 . -- . . r. • .w .o '5 o- a .Q 0 ~. . ~: - • . . ,, . -~t- - ----- ~ --• -- - :- -:. , 0
Page 883: wrm95d00
TP 983 ~ F1 1976 PDDL 50335 3398 FLAVORANTS--FOOD/FOOD--FLAVORA,NTS/ / CYCLOPENTANE DERIVATIVES/CYCLOBEXANE DERIVATIVES/BICYCLIC COMPOUNDS/ RING CO*iPOUtv'DS/ StICET F - •.IIVBF-77/55 .. 7. Recipieat's Accessioo t.o. 1• tt e an ~uouc e S• Report ate Scientific Literature Reivew of 6licyclic coapounds of July, 1976 Carbon, HYdrogen and Oxygen in Flavor Usage 6. 7. Atteor(s) 9. Performins Otaasizatioa Name and Address Flavor and Extract Manufacturers' Association ' of the United Sta-:es • 900 17th Street, NW Washington, DC 20006 223-74-2224 12. Sponsoring Oraanizstioo Name and Address 13. Type o( Repon & Period Coveted U.S. Food and Drug Adoinistration •Final - 1920 to 1976 200 "C" Street, SW Washington, DC 20204 ~•' The Scientific Literature Reivew sumrarizes the available scientific literature from 1920 tQ 1976 related to the safety of alicyclic compoiinds of carbon, hydrogen and oxygen in flavor usage. Chemical infor•nation, biological data, and biochenical aspects of these coppounds are given in a 573 page summary containing 1261 reference! 0 S ~ 0 t1 02S 6 A 7 0. Pcrtormins (Urjaoizatioo Rept. No. 10. Projeee/Tssk/Q'ork Uoit No. 11. Cootract/Graoc No.
Page 884: wrm95d00
~_ , ........~.. ~_ - . .._..... F21VI8DlQwN'IAL AEALT1i/AIR-POLLQriANhJATER-POLLVPIO;1/WASTE TREATMENT. VOLS.I--XVi/DIBLIOGRAPRY.VOL.7CVI/ WASTE DISPOSAL, VOLS.t-XVI/POLLIT[ION CONTROL,VOLS. i--xYl/SJASTE.INDUSTRIAL.VOLS.I--XVI/REVERSE OSMOSIS.VOL.IV/ HATEE TREATlE1fT, VOL. IV VOLS.II,V--JCIII/TOXIC SUESTApCES, LS.II,V--XIII/ { TD OR DISPOSAL RECO14D 1QDED METHODS OF REDUCTION 1QElTfRALIZATIO11 RECOVERY , . . . 897 Un 1973 OF IUZARDOUS WASTE. Prepared for 105. ENVIRA*iltENTAL PROTECTION AGENCY. By R.S.OTTINGER et al. Auxuat 1973 ilols.I-M Distributed bFs U.S.DEPARTMENT OF C024tERCE. National Technical Inform. Sarv. Pb-22458I-PB-224595 VOL. I. SOlQfAitY REPORT. Vol.!!. TOXICOLOCIC.=. SUFMARY VOL.!!!. DISPOSAL PROCESS DESCRIPTIONS, ULTIMATE DISPOSAL, I1fCIlIERATION, AND PYROLYSIS PROCESSEf VOL.IV. DISPOSAL PROCESS DESCRIPTIONS, BIOLOGICAL AND MISCELLANEOUS WASTE TREATMENT PROCESSES. VOL. V. NATIONAL DISPOSAL SITE CANDIDATE WASTE STREAN CONSTITUENT PROFILE REPORTS, PESTICIDES AND CYANIDE COMPOUNDS. 40, 1"OL.VI. NATIONAL DISPOSAL SITE CNADIDATE WASTE STREAM CONSTITUBN? PROFILE REPORTS, lzRCIJRY, ARSENIC, CBROfiIQH, AND CADMIUM COtiPOUND6. YOL.VII. rNATIONAL DISPOSAL SITE CANDIDATE WASTE STREAM CONSITUENT PROFILL REPORTS, PROPELLANTS, EXPLOSIVES AND .WARFARE NATERIB:[.. ~ • 10L.YIII. NATIONAL DISPOSAL SITE CANDIDATE WASTE STREAIi CONSTITIlENT PROFILE REPORTS, MISCELLANEOUS INORGANIC AND ORGANIC COMPOUNDS. VOL. IX. NATIOIIAI. DISPOSAL SITE CANDIDATE WASTE STREAM CONSTITUENT PROFILE REPORTS, RADIOACTIVE MATERIALS. WLS. X. INDI.STRIAL AND MINICIPAL DISPOSAL CANDIDATE WASTE STREAM CONSTITUENT PROFILE REPORTS, i XI. ORGANIC COMPOUNDS. VOLS.XII. INDUSTRIAL AND MUNICIPAL DISPOSAL CANDIDATE WASTE STREAM CONSTITUENT PROFILE REPORTS, & xIII. INORGAAIC COlU-OINDS. VOL.XIV. SUM`tART OF WASTE ORIGINS, FORliS. AND QUANTITIES. VOL. XV. RESEARCA AND DEVELOPMENT PLANS. • VOL.XVI. REFERENCES. I t i -on ox.s6.
Page 885: wrm95d00
FLAVORANTS--FOOD / FOOD--FLAVORAD;TS / pIBL1OGRAPH{C DATA 1• Repon No. ~~ Z. ]. Recipiene's Aceessioe Ne. SHEET F'LYl/BF-77/S7 4. ulc a J tt e S. Kepoa aee Scientific Literature Review of,Aliphatic Amines in August, 1975 Flavor Usage 7. AoeAot(s) ' S- Per(ormind (aRsni:ation Rept. No. 9. Per(oamina Ot4ani:ation Name and Addtr .s 10. Piojecc/Task/ltork Unit No. I Flavor and Extract Manufacturers' Association of the United States 11. Costract/Gtanc No. 900 17th Street, NW M'ashin ton DC 20006 ~ ' 223-74-2224 1L Sponsorina Oraaniz.uion Name and Addcess 13. Typ: ol Report & Period U.S. Food and Drug Administration Co.crcd 200 "C" Street, SW Final - 1920 to 1975 Washington, DC 20204 14. 1S. Supptcmcatery Notes ~ 18. Apsttatts The Scientific Literature Review summaria.es the available scicntifc literature fora 1920 to 1975 related to the safety of aliphatic amines in flavor usage. s Cj~mi,~~1 ~nfoZma~one,.bicZ]ogj,Fnl~data, and biochemcial aspects of these compounds 214 references inin ~ ~ ~ t (~ 8~ ~ ~ ~ ~{! . g s la. c n a n pa a b ,er ~ c 4 :
Page 886: wrm95d00
i ' ' ~Q ~T~ Dept. IINalth, Fdncatioa i Welfan. , ; -Fi..~.r.~ a~JRIG.. ,ad aa~~ ~ aad Drtg Ad.inistration ~ ! ~~ aad Drug Research Labs., iue: 200 "C" Street, S. W. 30 L'ver=teea Place Nashinston, D. C. 20204' ; ~ 8ast Oranse, New Jersey 07018 • . ' S. DEPARTi+3EHT OF =?jERCE • ~daW Terknical taferrpat~ Smice • a•v,; :. Tbe Scientific Literatare Reviev stimoarises the available scientific literature ~ f:o. 1920 to 1973 related to the safety of bcorbatea as food ingredients. ~, Cbaaical infor.ation, biological data, and biochesiul aspects of aacrobates ar 1. siren in a 96 page .umwary containing 262 refeiences. , :i -. .- .
Page 887: wrm95d00
SAFE) /FOOD--IlYGRSDIEtiTS j ~ SCIEIRIFIC LITERATURE REVIEWS ON GENERALLY P8-T13 8y5 370 va RECOGNIZED AS SAFE (GRAS) FOOD IMWtED1ENTS. 1l73 - .. \ • -- - Sockvilla. Maryland 0.& DtPAKlutas w w+-r" :- r.uMA TeeAeirai lafotawbo Saria 31Z- t!be Scientific Literature Review sv.aDarises the available scientific literature fro. 1920 to 1973 related to the safety of Choline Salts as 'food insredients. Chemical information, biological data, and bioche4ical ',aspects of choline salts afe giv.en in a 26 page summary containing 100 refaresees. • 4• • i6 . . ~ h!E SALTS , . Pk.l.rwi.o Or j;n-taau« Piawe si.J Ad•ir.., U.3. DEPARTHENT HEALTN, EDUGTIOl1 6~iELFARE, ~ Infornatica Iac. ~D ADD DROC ADMtiISTRATIOil, f 6000 Executive Eonlevard WASRIt1GTOli, D. C. ~~ KlY taT% t
Page 888: wrm95d00
f I ; revo.pl.an a~19i'67 ' FM Aipl DaJG ADltINIS?RASIOIf, Waabinaton, D. C. • ' WE Z;~"- b l il 0 s DEtAWMEN'! HEALTH EDpCATIOtf i WELFARE ~ ~... _._.~ , ......+.... ~. __~~-~ asa.sair Kw s. AJJ..s. _ , e a.ai abis seSaat 1fs ielrstitie Litsrater. Revien so..ariaa t fe litasacrtt fTom 19Z0 to 1973 rslatsd to tbo sdety of i.aswax aaa Japa. Wax ss food ingrediests. Cbe.ical iafotrtioa, biolosieal dita, and •iotbss+[eal aspeets of Seesvaz snd Japaa,tas are siw se •'31 pago wssw7 casuininf 129 refarracss.' • . . v
Page 889: wrm95d00
GMCENERAMY. RECOGNIZED AS SAF$)/FOOD--INGREDIENTS/ ANI SOLE ,HYDR07(Y-,BUIYLA?ED/ ma' SCIENTIFIC LITERATURE REVIEWS ON GENERALLY PS-223 $63 a r %i0 »°`.' RECOGNIZED AS SAFE (GRAS) FOOD INGREDIENTS - ~ 197~ Pgdwtsk, orz..: If lATED N_YDROXYAN I SOLE spffl,orius ors,niatia.= i /~d and DtuE ltesearch Laboratories, ~O LveT=teen Place Lst Oranxe. !ev Jersey 07016 Eaproduced by: ° ALS.nErARrHUT OF coraMRcz. faror 1920 to 1973 related to the safety of 3utylatsd Bydroxyanisole as a food inajredient. Chenical information, biological data, and biochemical aspsets of'jutylated Hydroryanisole are =iveain a 68 paZ: sumury containing ~1'he icientific Literature Review summarises ths-available scientific literaturi e ata, ,,a,.pt, gealth, Edoutioa jnc • ..d and Ocus Addaistratioa 200 "C" Stseet, S. V., Washinf, D. C. 3S. s IIIC. UQTdiAL TECRKICAL INFORKA?IOFi SERVICa CIPAIr A^~
Page 890: wrm95d00
.- 50335 3400 CRAS(CP.rBiAUY RECOGIiIZED AS '9AFE)/FOOD--IWREDIENTS/ rt~ SCIENTIFIC LITERATURE REVIEWS ON GEtiERALLY PB-22~ 862 • 3i9~3~' RECOGNIZED AS SAFE (GRAS) FOOD INGREDIENTS . JUNE 19 ,q : _ INUM COr1P0UNDS . . ~ ~s,,;,.;~,m, a,y ~,~,,,,, 0~~ S~. Dept. Realth, Educatioo, tfod and Drus Administratioa 1'lOO~~itco, Iac: ; 200 "C" Street, s.q• tsst Cud0 or. ~ Faahinston, D.C. 20204 ROCbille, Malyland i Welfare, 4 ~S.BEPARTk1ENT OF COEiRfERCE •. = oai TecAatcal tniormatioe Service . - !'6. Scieatifie Literature Reviev sumarizes the available scientific ~c literature ftera 1920 to 1973 related to the safety of A1u.inum Compounds as food insredients. Che.ical information~iolo=ical data, and biochemical aspects of Alaaiaa Cosrpounda are =iven in a 134 page stimoary containinR 203 teferences. .
Page 891: wrm95d00
wRi . . GRAS(GE:NERALLY . RECOGAIZED AS SAFE) /{40D--ItiGREDIPITS/ . a 50335 3011 SCIENTIFIC LITERATURE REVIEWS ON fiENERAU.Y RECOGNIZED T~. '370 va AS SAFE (GRAS) FOOD I NGRED I ENTS - UTAMATES T~aRO~r 1974 1974 - ~ pB-229 856 s ` •. sle+f.e.iws u~...=u,.. ,1aoe a.a Ada.w: tracor-Jitco, Iac. • Spoasoriag organitations + • ~ 130Q East C~de Dr. ~~ D. S..Dept. Health, Educatioa, & iJelfare ,~ '0.''"j Tood and Adain,istration jockvilie, Maryland 20aS1 'Ii ~~ 200 «C« St~reet, S. Y., Washingtoa,D.C. U. S. DEPARTt.1fHT OF CO;IME ; `' lufiaaal Tecknaal tnforcntiaa Serrict ~' ~ ` t. ~ ta..:ruac.. i'be•Scieatific Literature Beviev su~arises the available scientific literaeure- ' tt free 1920 to 1973 related to safety of Glutamtes as a food ingredients. ecti of Glntamates : Cbadeal lnfor.aation,.bislosical Q3bS~refereaeeps• sirea in a 590 pa~e umrsr7 containing Ir . . ~ .- ~ ~ • + . . . 51 9 .r. 11;
Page 892: wrm95d00
50335 3404 • . . ... ' . . • .. _ ~ , .. ; -GRAS(rEIi81tALLY RECOGNIZED AS SAFB)/FOOD--I yNGREDIENTS/ • J- '~ SCIENTIFIC LITERATURE•REVIEMS ON GENERALLY PB-223 851 ~ .t ~ . ,~ 376 ~j° REC06~IIZED AS SAFE (GFAS) F'UOD IHGREDIENTS; ' • '• CIUM HYDROXIDE AND _LCItX'1 OXIDE ~Y 1973 ~!' I~d"'sry a•'-"""' K'~""'~ w't'•s. ~ ~. Dept. Healtb, Education, i Welfare, ~ra" aed Dctit Research Laboratorias Tood and Drng- ltdainistration ;- j 4llis;ie• Arenue at 58th Street 200 "C" Street, S.W.* . • ~ Ksspstb, ltev Tork 2.1378 Washington, D.C. 20204 OEPARTUENT OF 1:0MMERCE I&WA Tec4niql lafotmAu Serrica C072. " .,.~_ !ds Scientific Literature Review su®arises the availabla scY6tiiic ' ~ literatare froa 1920 to 1973 rrelated to the safety of Calcius Hydroxide ~ ad CsLeiu. Oxide as food iugredients. Cheaieal information, biologicalY• data, and bioclwFical aspects of calciua hydroxide and calciua oxide ars given ta a 22 page sussary containins 108 references. 0 0" .,
Page 893: wrm95d00
GRAS (GFAERAId.Y RECOGNIZED AS SATE) %FOOD--IIIGRL'DIBN?S/ 'I 370 ~ SCIENTIFIC LITERATURE REVIEWS ON 6ENERALLY PB-223 857 'f . tfiE TIN !' ~ 1»s RECOGNIZED AS SAFE (GRAS) FOOD IN_GREDI_ENTSN ; ~. lkMr.iK Oras.isati.. N..t a.d M*nu ~11 ~~aa~ Qr~MIlni.w iia.e .ed Mdtfff , Ietor.atics, Lic. . S. Dept. •-8ealtb, Education & Welfare, - ~` T'6000 'Eieeut~ve Uevaid- -- f1 Tood and Dru Ad.i is t i n at .~ ~ = r on i boelnrille. Har3land- 200 "C" Lxecutive 3oulevard U. S. DEPARTLIENT OF CON1MERCE Rockville. xaryland - 9- AuGUST 1973 Watimal Technical Infomatiaa Service . The Scientitic Literature Reviev wmmarises the available scientitic literature •. ttot 1920 to 1973 related to the safety.ot ¢~ atin as a food inaredient. ~ Cbea<ieal infor.ation, biological data, and biocbsatcal aspects of Qelatin are given In a 104 page sus,oary contaIning 775 reterences. la~r/ s ° ~6a01~+G -
Page 894: wrm95d00
: . a : k , . - 1 . f• . .- ! t :f. . 50335 3413 --CRAS (CSNERALLT RECOCrIIZED IIS SAFE)/FOUD--IMGREbI81iTS/ ' "ET SCIENTIFIC LITERATURE REVIEWS ON GENERALLY TP - 37o v°.REC06NIZED AS SAFE (GRAS) FOOD INGREDIENTS PB-223 849 1973 IODIHE AND-IODINE SALTS ~~ f~or.atics Inc. •~Pt• Aea2th, Education i ifelfare, . iO~ ~~ ~!`inistratioa '~000 Executive Bouldvard MoNcville, Haryland 20832 DEPARTMEHT OF MMERCE : MAY 1973 CAO t:•~ Wilonal Tediaical iniotmatioo Service ~ 46.G ?he Scieatific Literatara Review su:.arius the available scientific literature from 1920 to 1973 related to the safety of Iodine and Iodine ' Salts, as food ingredients. Chemical information, biological data, and biochemical aspects of Iodine and Iodine Salts are.given iaoa 82 page. sw.ary containiug 414 references. tr- . 5 0` 0* =d. 4 Z n n -
Page 895: wrm95d00
50335 3~00 u.i.~...c^..::.1~.~ . pOOD;--ADDITIVES--GENERALLY RF.~ARDED AS SAFE/ S.T. PB -223 850 III He9-74 SCIENTIFIC LITERATURE REVIEWS ON-GENERALLY RECOGNIZED ^ AS SAFE (GRAS) FOOD INGREDIENTS - CITRATES APr:l •'yT3 _.,., - -- - -- 9. lia~.csinl Ocaanization Name and Address ~ i1Z ~nsoring Or6anization :~ame and Addcess Food and Drug P.esearch Laboratories,l'wc, U.S. Food and Drug Admini`stration. Maarice Avenue at 58th Street 200 "C" Street, S.W. ' Kaspeth, New York,11378 . -7- Washington, D.C. 20204 . _ ~ The Scientific Literature Review summarizes the available scientific literature form 1920 to 1973 related to the safety of Citrates as food ingredients. Chemical information, biological data, and bt~ochewical aspects of citrates are given 'in a.100 page summary containing 594 references. Distributed byY U.S. DEPARTMENT OF COM.*tERCE, NATIONAL INFORAIATION TECHNICAL SER ICE. ,- 777 -----•-~,.... ---~-~-~- _~., 050000-256 97-
Page 896: wrm95d00
. ~ 50 335 X: . . 3496 :- nILE-ACIDS/•GRAS(GMRALLY RECOGNIZED,,,o SAFE)/POOp-=INGREDZBNTS/' r' SCIENTIFIC LITERATURE REVIEiIS ON GENERALLY ~ ~ , PB-223 844 . J IT'm RAS% FOOD iNGREDIENTS • tG . )7o a 19'3 fi . MIC ACID ANDX-MVATIVES r /bdaows aci.. Na.e a.J Mhkss ~ U.S. DEPl. HEAL171, LDIICA?20N i WELFAIlE, ADli~l1l8?RATIpH D ;~;. ' ''# I . - RECOGNIZED AS SAFE Isior.atiea'Ti~e: 20~0 "~Stn et, •S.W., Washington, D. C. i400 txeeutiv E l d , e ou e.ar tockville HarFland 24852 8. S: DEPARTGIEtfT OF tx',~" C~ ~ioAal Tecbatcel iaferaiatiou c, tl e .- . : ti, I The SciestiEic Literature Review swoarisas the available scientific literature ,. t iros 1920 to 1973 related to the iafetF of cholic acid and derivatives. Food is%redieats, cheaical infor.ation, biological data and bio ehanical aspects of eholie acid and derivatives are given in a 108 page aumary containing 919 urerssep ApRtL 1973 i F I~! ~ ~
Page 897: wrm95d00
GRAS see also FOOD--ADDITIVES--GENERALLY RECOGN?r ED AS SAFE/SWEETENEP.S / y ~O ir ry1r. R suGARS, coRN I MWWft 0 370 un PB-223 853 ~ • ~ . . ~, 197 3 SCIENTIFIC LITERATURE REVIEWS ON GENERALLY . . . ; ~, RECOGNIZED AS SAFE (GRAS) FOOD INGREDIENTS - CORN SUGAR in ~ ~.~.~. . .~ ..,~ _~..- :... ~ •- p rlorainF Oaaaarzaciun hnaie and Addr s -~~` - ~ `i' ~-~- e . ,. _ •_ . !i. t s ! Inforuaties, InC. 11 SPO°s°rra6 OrE°nr2a:ion Nune and Address Q.S...Food,and.Drug Administration ~r 6000"Executive Bouleva"rd' ~p ~~C" Street, S.W. _~ --.JUNE 1973 ts. Abscrsct: Rockville, Maryland 20852 Washington, D.C. 20204 . The Scientific Literature Review summarizes the available'scientific literature , from 1920 to 1973 related to the safety of Corn Sugar as a food ingredient. Chetiical information, biological data,•and biochemical aspects of Corn Sugar are g4ven in a 392 page summary containing 4925 references. Distributed b}r: U. S. DEPARTMENT OF CO?tttERCE, tdATIONAL TECNNICAL INFORMATION SERVICE- . , . . • • . . . - - • . 0 S 06-n 0 2-'S 6 9.8
Page 898: wrm95d00
--- CRAS(CEN8R11L4.T •RBOb(KZED AS SAFE) /FQOD--DIGBEDIENTS/ SCIENTIFIC LITERATURE REYIENS ON GENERALLY ~i2i9iii RECOGNIZED AS SAFE (GRAS) FOOD INGREDIENTS -,SITOL 'bff~ ors.~saei.. mas.d AJim ss Iaformatics, Inc. • / II. S. Dept. Health, Education i Welfare, Tood and Drug Aiainistration 6000 Lsecucive nonlevard- xoekvi lle, Maryland 20852 Spoasorins Or=asisation: 200 "C" Strea, S. V., Washiegton, D. C. a. S. oEPARTUpIT OF COMiccE ~ y . 7 IMV ' NdW TcchaicW Intawsm cm,&. ~ uw,w . !he Scientific Literatvre ttaview s~rises the available scientific literatare from 1920 to 1973 related to the safety of Inositol'as a food itgredient.' Chesical 3aforaation, biolos:cal data, and biochenical aspects of Iaositol are given in a 64 page swwsry containing 5% referes,ees.
Page 899: wrm95d00
50335 3430 Stolman, Abraham (editor) PROGRESS IN CHEMICAL TOXICOLOGY Volt.me 1- 1963- Academic Press New York t 0 5 0 0 tl 0 2 57 1 9
Page 900: wrm95d00
~- ~,; GRA,~ (GI'1iERALLY B~QOi:NIZED AS~'$~) /1~QOD--2NG1tEDIENTS / ~ .~ ~: ~ _ RGA/WIILCU IW J/YC %Vrvw1 ~. •~ '~ ~ SCI IF UTERATURE REVIEWS ON 6ENERALLY n-2z3 as. f i. ` . 3i a. FOOD INCREDIENTS + JUNE 1973 PRBIC ACID AND DERIVATIVES ti : i O 1 on za rgan iKa4ti.as Sponsoring TA p~.td„ .,•K „ ,,T • 4. ~ , y~pd aad Druj Re,~earch Labs., 2nc. . Dept. Health, Education & Welfare, ~ Lvergreen Place ~ and Drug Administration Zest Orange, Nev Jerser 07015 200 "C" Stteet, S-. V., Washington, D. C. 0 U S. DEPNtTUEHT OF COaNERCE ==t! sos; 37t , ~ ~m Tccbnic, l tnformabon Service o~` ~b ~.,k, !Ir Scientific Literature Reviev susaarizes the available scientific literature from 1920 to 1973 related to the safety of Sorbic Acid and 1~ Derivatives as food ingredients. Chemical infor.ation, biological data, and biochemical aspects of Sorbic Acid and Derivatives are given in a' • 92 page su..ery containing 638 references.
Page 901: wrm95d00
50335 3417 :r ~- ` ~. OIUS((,'EpSgAL1.t RECOGNIZED AS SAW/FOOD--INGREDIENTS/ , ,. a. : a SCIENTIFIC LITERATURE REVIEWS ON GENERALLY '~2i3~as2 370 °1i 1973 RECOGNIZED AS SAFE -(GRAS) -FOOD INGREDIENTS '- j~BOSE ~ t'-- iiq Qssairs~w li... sJ Addrsss spolworift organiiation: Lfos.atics, Iac. 0•g• pept. Health, Education, i Welfare ~' f000 Ezecutive Doulevard p°Od„and Drug Mwiaistratioa ~ Osekvdlle, lSarylaaf 20852 200 C-Strset, S. W. , r Rockville lSaryland 20804 • U. S. DEMMENT OF MWERCE ~~ ~a1 Technical taictmatiaa Se~rice e~ X~ ;~. t >bs Scientific Literature Review sum.arises the available scientific literature i. ir+ot 1920 to 1973 related to the safety of Sorbose as a food ingredient. Cbedcal infor.ation, biological data, and biochessical aspects of Eorbose are • tives ia a 15 paje susssary containin 96 references.
Page 902: wrm95d00
50335 3413 -GRAS)CE t IZED AS SAVE) OOD--I19ZtREDIENTS/. w! 370 ~ SCIENTIFIC LITERATURE REVIEWS ON GENERALLY ~",~" 1973 ! '9'3 RECOGNIZED AS SAFE (GRAS) FOOD INGREDIENTS It ~UM TNIOS~ILFATE Spodsoring OrgaAizatioA: U.S. Dept. Realtb, Educatton ••+gnive Msew +y A"v•• Yood and Drus Administration f Itsablia lastituts .Ri:search Laboratories ianTclia $arkxay - •lbilaielphit, Ysaas~leaAia . r. L DfPABTiaENT OF CO'~.IERCE 1ldNad TeckWW tafondioa Sefte 200 -Cr Street, S. W. Vashingtoo. D. C. 20204 i Velfa The Scientific Literature Review suaoarises the available scientific literature from 1920 to 1973 related to the safety of Sodium Thiosulfate as a food ingredient. 't3eateal inforaatioci, biological data, and biochemical aspects of Sodium ; lhLoetiWate are, given in a 6: pase susossr containins 366 references. ,A o -. :.. - s .~. •f._s,, :n.
Page 903: wrm95d00
50335 3q21 LiJNGS--IHNALED PAATICULATES/AEROSOLS--PULMONARY RETENTION/RADIOBIOLOGY/ RADIOISOTOPES--HUNAPi METABOLISM/ANIMALS- 1MEDICAL RESEARCH/RADIOISOTOPES--TOXICITY/ _ .._ ANPTCTAZ: 1tHPnR'r"Z>F'"THB - - IF-4b Category: UC-48 LOVELACE FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH 1231 In 1973 ~ ALATIO~t TOXICOLOGY RESEARCH INSTITUTE u U~halatior Toxico ogp esearc ns e i, December 1973 Prepared for the Diviaion of Siomedicaland Environmental Research Atomic Energy Commission under Contract No. AT(29-Z)-1013 ALBUQUERQUE. NEW MExlCO $7108 Edited by ' October 1. 1972 throuEh September 30. 1973 bby the StaH of the and F C Ru ht T h i d . . pprec , cc n cal E itor 1 R h I tit t
Page 904: wrm95d00
. . _~., , ,. . Ty __ r1711.iTTlair'--i4ATE1F/CItMIICA1.5--TMCALOCY/ 7~ %L"CT C~:+I-_i~ ~?A TH ~ ' ~ ' WATRR~-P a . I, E FFF C *! E'3 Tf F•d~?: ENT AL H6AL !U / 891 1Sn 1971 WAT£R POLL[.TILh+ .`~iTFd~iL R~^.SP.: RL"# SERISS. wa lit G' ' ; k a Y I 2 x, r, ~_t oo , Q~~ Oata fl . t,~x qys . IJ4RGANIC CHEMICAL rOLLL'TIOH OF FRESMA'L`FS by Atthur D. Little, Inc. - _ Adont Park •Cambr3dye, sassactusetts 02140 far th. U.S. ENVMIr.^~iENIA L~iENIAL PROTELTI04 AG~C! 'Projett #180I8 DPV Contratt #14-12-538 Jn1j 1971 ~~ ~i l1 f~ ~'~ i' • l.r ab by tbm BYqeswlaJ.ut of Dotutgea% 11.S. Oe.etemt*t hinWt Otda, K•ash;utw, D.C., ZMi -?rla. ~S H N ~ ~ N ~ ~ 0 N .. _ .. .. . , . .~~r ~.. . - . •_ . . . . . .. _ - ~ t ~ ~ i ~ .~. 0s0a~ox srtt . a 0
Page 905: wrm95d00
50335 3405 ' ~Ag(Gg?1E~AI,LT RECOG4IIZED AS %4AlE) /FOOa--INGREDIBNTS/ -' ~. SCIEKft~IC LITERATURE REYIENS ON GENERALLY RECOGN~IZED l973 AS SAFE tGRAS) FOOD ItIGREDIENTS, CIUM~~ESTR~WTS • -~` )ro M. i'. O~ssias~fM Nawe wt Aai4ss 2~••~~i o~~wia Kawe as - t~ealth, Edqcation, b lreltars,- V! I}~orraties Ise ; Zil • ~~ - 0000 Tacecntiw aoalevard ~~~ and,Drus Adainis,tration ~ O~ Street, S.W. i- •, 8oclville. ttarrland 20852° 2UU MAY 1973 S. OFPIIMEiiT OF CONUERCE Wa•atn<toa, D.c. 20204 ~ ~ ' u~s• P8 ,,_ Tc"aial fRfanUtton Saffici ' .223 843 ~ ~ The Scientific Literatvre 8eviev summarises the available scientific literature !i^«t 1920 to 1973 related to the ~afetp of ca2ciuo sequestrants as food =nitedieots. theaical inforaation, bioloaical data and bio chemical as ects , p of tolciuM sequestraats are given In a 144 pa=e sumary contai3kins 1050 retereoce: ' ' • ' • . . . . __ _._ ` ~ ' ' . . y ' `- ~!_-___. ~__ -_. ~_. • . .• ~ 4 ` - ~ . ~ . :. lk i i :. . . ~
Page 906: wrm95d00
1-1 SAl'iS 3r1A • • % - GRAS(GEtiE1W.Lt R8t'AGNIZED AS SAF6)/FOOD--IIiG1MDIENTS/ ~. f: ~ 4 ADGDS? 1973 a SCIENTIFIC LITERATURE REVIEWS ON GENERALLY ps-z23 eao 3~7a RECOGNIZED AS SAFE (GRAS) FOOD INGREDIENTS -,SI(~IC ACID ' SPonsorins Ort,anisation ~: Ir, i L[orantics, IAc, Q• s• Dept• lRealtl~, Education & Welfare ro°d~And Drug Adainistration iDOO Extcutive Eo"evard ; ~O'c~~e :e: ~=71and 20532 - ~~ Street S. V., Washington, D. C. .. 3'I } M. S. DEPARTMENT OF COMMERCE ! NAaat Tecbaui lafornudan Senice Ca d-5 !6a ScieMi.tic Literature Review suranarises.the available scientific literature frow 1920 to 1973 related to tha safety of Succinie Acid as a food ingredient. Oaiical inforsiation, biological data, and biochesacal aspects of Succinic Acid are ii.ea in a 45 page suswarr eontainins 441 references. ~ . 7 s <
Page 907: wrm95d00
• 50335 3419 ~:. ~ .... _. -~.GxM(4"SNERALLY REOOMZED..AS SA72)/FM3~"-INGMIENTSI m' SCIENTIFIC LITERATURE REVIEWS ON GENE Te RALLY PB-223 859 , ~~~ °` REOOGNIZED AS SAFE (GRAS) FOOD INGREDIENTS, JutY 1973 I IAUN AND STEWIC ACID i~IL 0~ . Dept. b.altb, Education i Welfare, ~ors~aties, Iae. ?d0E and DtuS Ad.inistration Wj00 Taoeeutive foulevard 200 ~C" Street, S.W. Sockville. Maryland 20832 WashUSton, D.C. 20204 1 pqs su..mry caata3aiaS 347 sat.reacss. . . . . ~ ~, The Scieatific Literature ttaviev sumaariscs the available scientific literature froa 1920 to 1973 to tha safety of Tallow and Stearie Aeid ara =irea i. : 77 DEPARTEiENT OF CO.1MERCE ; ~ ~7Gt ~tco~l Tecbnic;i lnfcrm=tian Service ,a6 , ~ ~ . . . , s :. ;
Page 908: wrm95d00
50335 3431 ;T 55 {S -~--•~- ~ Stewart, Corbet Page, ed. Toxicology: mechanisms and analytical mctbods, edited by C. P. Stewart land, A. Stolman. New York, Acatdernic Press, 1960-61. 2 v. illas. 24 cm. Inclndes btbltograpby. L Tozicology. i. Stolman, Abraham, 190S~- joint ed. ItA-i'LIT.S73 ~,~ r'~ 615.9 60-8055 rev 2 Ltbrary o! Congrees tr64h*3j 0 5 0 0 n 0 .2 5 72 0 .,
Page 909: wrm95d00
SQ333 3~2 9 MODERN ANALYTICAL CHEMISTRY Setles Ed•tw- Oavd Hertufts vn,..n.ty of Arr.ar.gh : CARDId1/ASC1?[.AB DISEASE/MYOCARDIAL IIiFARCTI01i/PATTERN RECOGNITION/ 'TOXiCOLOGT/CLINICAL CEtEMRSTRY/CHEMISTR?, CLINICAL/ HEART--DISEASES--DIAGidOSIS/ tEt$OLQM INDUSTRY ANALYTICAL APPLICATIONS OF ATOMIC SPECTROSCOPT/ AbT;POLLUTIOIi/ ~ ~ ~. ~ . ~l~~d 4.% '~ /~~p~~C ~tros~ , ~ opy • ; Volume 2 - EMed b„ . . E. L. Grove Q S 0 0 0 0 2 S PePu0' Press • New York ar.d London I
Page 910: wrm95d00
. by Fsiutu ZwzwtN 50335 3S 26 ToXINS/ I F NTIA 15.12.1973 1~ Toslnoto`y. Continuation of the mWtidirci- piinars rvNiew articles from Eapenenua 39. 11. 130-1334 (1973). Departmeat of Entomology and Venomous Animals. the Hebrew tini.•ersity of Jerusalem (Israel) and Biochiaie. FacultE de NI(deciae, secteur Nord. Nlarseille (France). In areat years the field of research on animal venoaa is in a stage of a constant expansion and it has been dairrtedt that about 10,000 papers are published every year on this subject. This increase in the scien- tific interest for this field represents a certain essential thaVe in the applicative as.rell as theoretical attitude to the subject. In the past, the medical aspect of venoms s,!rved not only as the primary motivation but as the sole purpose of work. However present toxinology passes beyrood the medical scope and venom: are used as: tools et the study of essential physiological process-s and pbenomena, poteniial sources fo- ncw therapeutic by the common parameter of mice LD", thus enabling a convenient comparison. The structure of certain toxins is pr ~entend in Figure 1. Surveying Table I. one is impressed by the .vide range and di~ersit}• of groups and species of venomous animals starting from unicellu- lar organisms up to mammals including the main phyla of marine and terrestrial animals. This is accom- panied by the heterogeneity in the anatomical devices for the formation and release of toxic substances, starting from the simplest forms of storage in the bod}- tissues as in case of poisonous fishes' or certain beetles4 up to the highly sophisticated stina ng appa- ratuses of certain arthropodss. Highly diverse are also _n~tl;nlr~i~t~ftec±~„cat~c~rL~: -aeeots__:krtd_as,.de•1ce; _fer_.*.l`a__;tu4< ~n_zttQe:nlQrici l._ the- 0` S 0 0 c1 02 5 7 1 S E
Page 911: wrm95d00
50335 342e ' ~ /TIPX/tIL o~ry "' " ~ Cff~iN~rr~ty~~lr~tyT/G -- ~sr~t~lATw~YE'.a, Prlrr, P,~lw~tA yllc 4?iIgHlirArivar V co~o~"Ooe ows - - A i orow tft vt rf F Manual' I 97/ 1% . 0 of Analytical ~'.olo Publisi:cd by
Page 912: wrm95d00
' ' III Me9-79 POOD--CONTAMINAN?S/SILICATF.S-TOXICITX P. - S ~ . . . :. '/D15T$'SGE . .,_.~. M REpWT OOCUMENTATIQN .4.atrows wo i i . .AOt -79 u ~- u rbb 4. T"m a" ,No* lbea:raph on ~dfna tiatasilicata ~ ~ ~ a~ ~ . ?b~y 9, 1976 r a ~' (red Wasasl.r, Ph.D. SODIUM ZJNC jrIBTASILICATE/ a wav.l+.a a.«+..«« i rra..+s amass.« w... w..r... . . sa n.+..w*...nruo um N. Intor.atics Iae. . 6011 Fsecativ. 3oulahard ~ u a..cwa « a..lw ~+. sock.iil., M 2os32 w 223-76-2001 r O M s.ON+«w aw.anm wm. w ss %.,......e a.w o,..w. Food aad Drug dddaistratio s 200 C St. Sli. • " . ' Fyaais 1920-1978 ~ ilaahibitoa, R,;;, 2Q204 ss 4
Page 913: wrm95d00
50335 3432 I I ~ ~ . ~ ----- • ~ -- ---r - - - -= ~-=1 Ref. Q 123 Su Jc. re~~ Q 123 Su 1 Sur.ehine, Irving 19ANDBOOK OF ANALYTICAL TOXICOLOC:'Y. 1969 10R1 parc* The "uentlCal 1:i1b1izY Co. CieVZliinu, t:ltio 0 ,~.~.----- o s o 0 o a z s 7 1 t 7- ~.,.~--~... ~~
Page 914: wrm95d00
Maxwcll Scieuttfic Iut£rnationel Inc. INDUSTRIAL TGXIC4;,O.s3 A:~~ OCCL'PATIUNAL UEt:LT#i, AN I1JTEfiNIATIONAL BYBLIOGRAYHY. Maxwell's Internstional Subject $ibliography No. 33. 1964 19 p. International Inc., The DoccuaentEtion and Procurerucnt Centcx yeW York 0 0 5 0 0 tt 0 2 5 7 2 4
Page 915: wrm95d00
5033S 3427 , . AIR--YOLLUTION--REALTR EFlF.CT XIC SU$STANCES/ ~. cHErricAi.S--TOUICOt.OCY/ ~ EPA-4.Sp/3•??•008b 123 ;Un - - PRELIMINARY SCORING 41976 ~ OF SELECTED ORGANIC AIR POLLUTANTS '~ APPENDIX I -..T1, PRODUCTION CHEMISTRY , , _ .~ y Prepared for AND TOXICITY `~;: Dorls.e. I. Fullw and R. Dulf, EIYVIRONMENTAL PROTECTION AGENCY Office of Air and w.ae Management OF CHEMICALS Tb. Mitr. Corporation Offioe of Air Quality Planning and Standard. :' . M.ttelt Di.isim R.Nareb Triangle Park, North Carolina 27711 . Ontg.t. Research Park o«~ 1"s A '~ROUGH ~ ~ _ . . :~„ . Coetr.et No. 6642-1495 0Sn0o0257'1 6 ' r~... r.. . 'EPA Psojeet Orfieer. David R Patrick
Page 916: wrm95d00
11 50335 3033 . . Q 123 S . Spector, William S ed. I-Iandbook of toxicology. Prepared under the direction of the Coinmittee on the Handbook of Biological Data, Division of Biology and Agriculture, the National Acldemy of Sciences, the National Research Council. Philadelphia, Saunders i°1956-,,; '/ ~ .. 28 cm. Includes bibliographical references. GbxrsxTS.-v. 1. Acute tozicitles of solids, liQulds and gases to laboratory animals. Vc~l. I I. Anti bi ot ic s. 1. Tozlcology. i. Titie. RA1211.S62 l"'N 615.9 56--1'i976 Ltbrary of Congress 15TzTj o s o o n o2 s 72 2 c
Page 917: wrm95d00
34 37 IRON/ENVIRObiAtENTAL NEAL'rFi/ IhDtiS'TRZAL TOXICOGOGY/ t ' ° s.. 11 Meal-74 AIR POLLUTION ASPECTS s'p' OF E1IIISSION SOURCES: EPA-4S0%'74-004 I FERROUS FOUNDRIES A BIBLIOGRAPHY WITH ABSTRACTS RNVIRO.YMENTAL PROTECTION AGENCY Ofifce of Air and Water Programs Office of Air Ruality Planning and Standards Research Triangle Park, North Casolina 27711 Yarch 1974 Air Pollutioa Technical Information Center Bibliography contains abstracts of the available literature pertinent errissions f rom ferrous foundries, the effects of those crzis.~-ions on and his environment, and feasible technology for their control. to man
Page 918: wrm95d00
V r . S033S 3441 RA , 11147 ]so Carbon monoxide poisoning. Edited by H. .Boux and I. McA. Ledingham. Amsterda2, New York, ElseviQr Pub. Co., 1967. 203 p. illus. 27 cm.
Page 919: wrm95d00
i- . a• ~} • . . rou i . . - .-. , s• LSf -. ... . - . - wJf. a 50335 3%Z0 .-__.GRAS(GENEW.LY R~.'COG'NIZED AS SAFS)/FOOD--INdREDIENTS/ ,. !~~ SCIENTIFIC LITERATURE REVIEWS ON GENERALLY REC~Ni 3~asa 1973 AS SAFE (GRAS) FOOD INGRED I ENTS -~N IC AC I D A1JG0.Si 1973 Sponsoring Orgi`e~sation: U S, Dept. Health, Education i Helfare, f'.Yd and Drug Adainistration 600 Executive Soulevard pashiagton, D. C. ' >ockville, MarTland 20852 : . B~E PARt YENTPARtYENT OF COMMERCE _ ~ Techoical latormatioa Sotrice R.o 3 7.1/ M' 1 3 'X~C' t - !re Scientific Literature Review suamarises the available scientific literature fco. 1920 to 1973 related to the safety of taanic Acid as a food ingredient. Mdreal Information, biological data, and biocheadcal aspects of Tannic Acid I ~w s+..a a.a a o& page sussiary containin= Z37 reterences. i .1 © • -V.-'V. .2 V Z' ..a - 0
Page 920: wrm95d00
ADVANCES IN CHAOMAOGBAPHY, edited by J. Calvin Giddings and Roy A. Keller. v. i-~ 1965- .Marcel Dekker, Inc. NeW York
Page 921: wrm95d00
SYNTHETIC SbIEETENERS /SWEF.TENERS /CYCLAMATES / ~ XX HeC7 -74 S.P. A wLIOGRAPHY TOXICOLOGY INFORMATIOY RESPONSE CENTER BIOLOGICAL EFFECTS OF SACCHARIN ORNL TIRC 73-13 *"` Helen S. Warren June 1973 Work supported by the Toxicology Information Program, r.i a , S.. ~%u.G-4,4L/ -V-e,%.GjY .~~ /31 National Library of Medicine, National Institutes of Health, 4LY Departmeri tioa-;-and--Weifare under NLM Interagency Agreement No. 40-274-71 OAK RIDGE NATIONAL LABORATORY Oak Ridge, Tennessee 37830 30 / L'ar ~Se~ operated by ' ~ UNION CARBIDE CORPORATION ~,ryPow _,7 • for the r f ,q O. S. ATOMIC ENERGY COMISSION
Page 922: wrm95d00
50335 3R3• /f/4 - ; ~ ENVIRO HE VINYL CHLORIDE/AIR--POLLU'~`ION--BIBLIOGRAPHIES/ 4' `~6~ASBESTONS~~ ~~PESTICIDES--TOXICOLOGYf 3. Recipient's Aecession No. <. Title snd Subtitle Ir.dustrial Factors Health Hazards Due to Atmospheric (A Ab1io_araphy_w1 th 7. Author(s) Elizabeth A Abstracts) Ha rrf son 9. Per(ormina Oraanizacion N"e and Address l' . J. f. l~ational Technical Inf _ ormatt on Servj*ce 5285 Port Royal Road Springfield, Virginia 22161 1Z. Sponsorina OraanS tion Name nd Address 1S. Supplementary Notes Supersedes NTIS/PS-75/022 NTIS/P:'-75/800 S. Report Date October, 1975 11. Cootnet/Grsot No. 13. Type of Report & Period Covered 1970 - June 1 75 9 The bibliography. contains abstracts of research reports covering' such tcpics as 3adustrial medicine, occupational diseases, health of miners, arid the toxfco ogicpl factors p~' varipus pollutants. Sqme pollutan:s include are,~ang ese,r./radon,silicon dioxide, plo ives,•asbesto 1~i~m lladium, p lyviny2 chloride, ickeG, 6eaA1d&,0~chXom3ud, 1a t.ics and vanadium. (Contains It 202 abstracts) '4O *0 "4t
Page 923: wrm95d00
S033S 3439 .RA 1190 We 1982 .44 SOURCESJ
Page 924: wrm95d00
50335 3045 Ref T ~ 55 )G - - -.--- -"a• .r w ~ Cleascn, 'Har9.ca N. CLi':IiC.'.'. ~'J:fiC4LOGY OP CC*i}qERC2AL PRODUCTS - (ii0ME & c1.nH) , by cfsi i on N. G1L a?Or., R.ber. t E, (',osselin, and Harold C. IjGC;-a3. 1963 vari.o-ja1y paged Tl:e tiilliass 6 Wilkins Co. Baltimore, 'id. Q5 0.000_25 71 4
Page 925: wrm95d00
50335 34141 ~ PESTICIDES--DETERMNATION/ / ~ • _ ~ ~ CHROMATOGEtAPHIC ArL4LYSIS--CHEMICAL'COMPOi>r1DS/ NITROSAMI:VES/ • i T • -• 27I Fi FOOD-ADDITIVES~--ANALYSIS/AFLATOXINS/MYCO'POXINS/CYCLAMATES/ "'72 S~TION/TOBACCO--SMORE--NITROSAHINES/ DRU6 --~L Y IS R-'-CAU _ ~ _~HRMATVCiRAPHY O 4~NVIRONMENTAL HAZARDS • N BA~~ ~RCINOGENIC SUBST ~ ~ CE VbLUME I f, b . . : • . ARCINOGENS, MUTAGENS AND TERATOGENS : _ LAWRENCE FISHBEIN "~ GRkf, Aaalytlcal & SyxtheNe 0mrxJstry Bear.eh, Natlonol lastttate oj,Envtrommatal Health Sctances, Jiosoorch Tidmrj*k Park, N. G, U.S.A. AeWact Projes.ror ojEuonwlojy-ToxicoJoSy, North Carolina State Urrtveasitr, Rokrrk N c., us.4. .-.ELSEVI.ER PUBLISHING COMPANY = AMSTERDAMILONDONINEW YORK:
Page 926: wrm95d00
50335 3450 xx Je Jenssr.. :~, ?;, F"D "0ou11NCS JWD CoAOo+rlid3 0F IMAIQD $~R ~i GTtJR~ :: .~ CilY6 Q~AL YOX ~.G.17Y . :rean . . :r .. %i. ~ ., ~.~:... ::. ." . J.' . . . •; f ~ f. ~a w ~' "f ; ~. y1 I. .. . . C . . .. . _. . . .. , . ~. ~ . . a n . 327-30 ( If41') I .0 .:. _. _ . . _..L.. ~~__ . T-...-..t~~r,..T..~" 0 5 0 0 n025739
Page 927: wrm95d00
V jl~'-~..~ 064 S ozo) ~ ~ r• ` ~",~ n ANNUAL L1..'7 0 % / g 7/ Z , 2/.~.S National Institute for Occupational Safety and Health ~. U. S. DEPARTMENT OF HEALTH, EDUCATION, AND WELFARE Health Services and Mental Health Adm:nistration National Institute for Occupational Safety and Health 0 rj 0 0 0 0 :4 RdcJle, AZ 20552 -- 1971 ~ S033S 3440 r
Page 928: wrm95d00
50335 3442 LibyQ y y ~xic,o[ oo.y- -.l4V.4Ayrit;*t #*,CroOV.or ' o/c/yE.•.~c~~-s-- y'oXic.to~y ~ yFM~rr~y, ~l~i~~yr~c -- qaw~cir~rwE~cs~',~~r.rrny,~lw~~rrl~ 4?iIAA,#r/ rA r/ re/C I~fEMit~'x,ri i!~/.It yTic -•AYA 4,0KiOAS./ po1.Pow s--Ar~t yf.•V Poij~~ -- roX. co.coAPy/ ~9 u ss •- ~ ` irt~t vsi f/F (t: f rs's'GIf~ I 97/ r • , Manual of Analytical
Page 929: wrm95d00
5O 3 3S 3t 3d t~TAL4/. ENVIdQNM€NZAL' HEALTH/..,.~- t INDUSTRIAL TOXICOLOGY/ EPA.450/1-74-U03 II HeA1-74 S.P. AIR POLLUTION ASPECTS OF EMISSION SOURCES: PRII!'IAR.Y'ZINC PRODUCTION A BIBLIOGRAPHY WITH ABS141RACTS .&Bibliography contains abstracts of the availablcs literature pertinent to emissions associated with the production of primary zinc, the effects of those emissions on man and his environrrent, and feasible technology for their control. Air Pollution Technical Information Center ENVIRONMENTAL PROTECTION AGENCY Office of Air and Water Programs Office of Air Quality Planning and Standards ~..rch,T±-iansrle. Pa,r_k,,,,I~orth Carolina 27711 - .~...----- . _ l 0 5 0 0 0 0~.5 7 2,7 -#
Page 930: wrm95d00
50335 3448 ATER--POLLUTIOM/AIR--POLLUTION/ nnw1iu.--1UAi'6uLwr/ SMpKING & HEALTH/ ENYIRONMENTAL HEALTH REVIEW NO. 1/ .RA 1230 St 1980 PRIORITY TOXIC POLLUTANTS ~ Health Impacts and Allowable Limits EdiWd by Marshall Sittip NOYES DATA CORPORATION rar. /11+... N.. JW.r. U.f .A. "No - 0 5 0 0 0 0 2 S 7 3 )
Page 931: wrm95d00
50335 3423 RA mI1TA(:RNS /CARC I*lOCENS / S.IFETY COaES / 12#2. fwltT %Un. .. twN..t f+Mi.M •1976 tkie.et. r.e /l.e.wreed aat ~qoa.r, a c.pet Cy.aid. aod aa)t -•- ~ / TERATtx;1?NS/ •~Kq{aslwC.I1Ta . N~ ~ Iffpllb • V~ .... tt~s.d Oct. 1l7I ida lalts (1taQ1. ta, asd a• . . .~..~.~ • . aft ae..:.,d.. R.p. T. ay.$«i.r MaN ..d AMr... 10. p,.iec .. ..Y N.iw M.. ttatiotrl Isstitrta fot Oceupational Saf.ty aa/ D.olt1 467i Golu.ria Pkrt. L r•" °i" N'' cissieaati, OkLr 4St2G Racossndsd ertttTia fes' a.taal.N iwtasd.d tt protoet tM bcaltk of vorksrs ,pinst acposura tq kpdrope c~ido and cyanide salta, ospostally sodtum cyanids, potsssiu: e~..ids and ealetua c7aida, for up a a 10-hour work shift, 40-hour work vesk, owr • UosLtas lifattaa. Oeenpationsl oxposuro to tAasa eos+pounds is deftned as eipoeure to aitloc"a eeecsatratia4. trsatas thsm the oorr.spondtsg .ctim 1s..1s, or ona•Aalf the arr.opoodiag eoeaasndsd eoilins on.iroe.rntsl ticpossra lisit. Tfia :uts topics aawrN tosiudap roeammeodatioua foe lorols of er.ida !a the .rorkplaea air, in- alndins sempltss and afslysis{ .adical wrv.illaaa= porsosal protective equiprnt aui elotAiog= tafor.tas awplopess of eys.ida Aa:ardsl vork prsctiees and control Peee.ducss= saaitatto®, .onitorin` and rseordkaspins= Atologis effects of expo.uro, lasludiss opidsatolop, c.areino{atetty, sutasaeieity, aad tsrst"eoteity= sn.tcon- Tptal data and sllttMKias cOOtrOlt. . .As ~ , Ae. r.w w .aywn llsalpsi~ - Me.ntoloey M.eeti.e nNieta! Csrelno~sns `af'`' es0 t]0 2 57 1 x .
Page 932: wrm95d00
50335 3452 ....~,.w. ...:,.:.~.j.~.:K:,e. III La4 (1970) Larson, P. S. CtsRONIC TOXICITY STUDIES ON Ti,O EE'OXIDI7.ED SOYFFII: OILS IN Tt1E RAT AND p0(:, by P. S. Larson, J. K. Finnegan, H. B. Haag, R. B. Smith, Jr. And 0. R. Hennlgir. Toxicol. Appl. Pharmacol. 2, 649-58 (1960) 0 0 S 0.0 t1 0. z 5 7 ,4 1
Page 933: wrm95d00
50335 3455 I CoA-S1 0 © 0 0 0 A&\ • C~~ 0 0 . i ( A Statement by the Research and ~ Pdky CorruNt#ee of the Conunmee far Economic Developrnent April 1981 0 5 0 0 0 02 6 3 4 8 0 ..+.
Page 934: wrm95d00
~ ~ ~ 0 ~ ,. FOOD--POISONING/FOOD--ANALYSIS/FOOD--CONTAMINATION/' - - TTRITES/TRACE ELEMENTS/MYCOTOXINS/TUMORS/CANCER--CAUSATION/ ~IONAL RESEARCH COUNCIL, FOOD AND NUTRITIOIZ BOARD, CO"~4`tITTEE ON FOOD PF.OTECTIG': TP 3 70 Na 1973 SECOND EDITION ~ { .~~....~_ ~, _„_--.- I TOXICANTS OCCURRING NATURALLY IN FOODS NATIONAL ACADEMY OF SCIENCES Mutfttoa+, D.C. 1973 0 o.a.. 0 2 5 s 7-4 3 3~z ~ 70 e~- 0
Page 935: wrm95d00
Schramm, Robert J., Jr. The transpiration of Black shank-infected tobacco, by R. J. Schramm, Jr. and F. T. Wolf. Frorn: J. Elisha Mitchell Sci. Soc. 70:255-61 19 ~ S oa o•-:n o~.:b 3,5 o
Page 936: wrm95d00
50335 3460 RC T1MM& OF' . 2 54 ANRlliii, A ATLAS OP T1AMOR PATDOIAGY, SBCTx02t XII•FASCIC1rE 40; TRAIaSPLAN?ASLS AND TRA24SHISSIBLE TWOR! pt ANIHAL3, by Harold L. StewaYt, 1Gatharioe C. Soell, Lucia J. 1Suahm, and Samuel H. Schylea. 1959 378 p. Mned Torcaa Inst, of Pathology Waahiagtoa D. C. I ,4 .t: .. . ._ Q500~0~_b35:3
Page 937: wrm95d00
EitVIRO*W?AL HEALTH/CA1tE0N MON0XIDS/ /CONSITMRISI1 PESTICIDES-ENVIRONMENTAL FACTORS/DIBLDRIN/pITROSAMINES/LEAD/DDT/TERATOGENS/ MTT/IiCENS/ASBESTOS/RADIOACTI`/E SUBS?AIiCES/PHOSPBOROt1S COMPOUNDS, ORGAIQIC/ SDLftJR DIOXIDE/NI?ROGEN OXIDES/INTERNATIONAL ACADEMY OF EIIVIRprQOMAL SAFB?Y/ :, s7 ~; Environmental Quality ~ and Safety . Fde~nCa,hca+. ARwr, rt 7r 1974 ..._ . . . . ~.. 107A r vawaa nspcvu or %.ncmuwy, Toxicology and Tahnology -= ~~ ~+' '~ ~~ r M, ~ „ Y as Applied to the Envirooment. - A Swb"wy of Hwcoun gr&m pbr
Page 938: wrm95d00
50335 345e COMPLETE ARTICLE AVAILABLE UPON REQUEST Aff9- 9 Y Jiant Jour. Apria Re& Vo1. 2, N.?, March 1974 . • .. Z-A. 0 J l l~y~ 7s~~/Il f'a' , ~~ HYDROGEN-ION CONCENTRATION OF THE . ~ R0jU NI PIA IN RELATION TO , I L; Ar-% Fadtoomand, L. A. Peterson, and T. C. Hall- 0 5 0 0 0 0 2 6 3 S I I i
Page 939: wrm95d00
CANCER-CAUSATION CJSCBR--CONG1tESSES INDUSTRIAI. TOXICOI.OGY/: '. DIET/CANEER--BLADDEI!/pESTIC IDES---TO:lICOLOGT/ CAIICER--8SOIHAWUS/S:iU"/CHEHING TOBACCO/F00D-1lDDI'!'IVESCI.MGEVS/ TOBACCO--SM[IliG--HEALTH EPFECT/S'_~CIiPG AND UP.'ALTH/ TAN11II13 gEBR/NI:tB/ CAB=--CAUSATIOII YBE:COI.S/ALC0RdLISt/ DEVELOPMPNTS IN TOXICOLOGY AND . AI. SCIENCE, VOL.. 4/ RA 1191 Ds 1979 TOXICOLOGY ANq, CCUPATIONAL MEDICINE Procerec&ngs of the Tenth rnwAmericsn Cantererue on Toxicotogy and (kcupstjonsl Medicine. Key Bisceyne lMWm7. Ftowids. October 22-2 5.1978 orgawzer: WILLIAM B. DEKHMANN, PfiD. MD (ta~ l*A"y of Miamr Sdwo/ of Medicine, MWm florid4 USA ELSEVIER/NORTH-HOLLAND NEW YOAK j- AMSTERDAM • OXFORD 0 5000' 02 5136
Page 940: wrm95d00
50335 Mm ADn lIVES---TOXICOLUCY / 3 %q9 P0ISONS--T0XiCOLOGY/CANCER--CAUSATION 1!Y EN?IRONHEpTAL FACTORS/ CAKCER--CEOGRApHICAL/CA1lCER--CAUSATIOK BY CREMICALS/NITftOSAHINES/ TO7IICOLOGT--ACUTB TOxICITIES/DRDG ABt]SE/11ITRITES/rITRATES/ y,.JZTAL.I--LVXI - TTnK RY. HxTAi QLSML~1tl~r.AZO:ri[i.+rsi.. TOD/1 ICING--HEALTH EFFECT/ RA 1199 Me 1979 Advances in Modem Toxicology VOLUME I w CONCEPTS AFETY EVALUATION i • Part 2 EDITED BY MYRON A. MEHLMAN MEDiCAL DEPARTMENT, MOBIL OIL CORPORA7ION RAYMOND E. SHApIRO. NA7IONALlNS'i'ITUTE OP EM'I1tOMlENTAL HEAL'i7i SCIENCES , a s o oa 0 2 S ~3 a HERBERT BLUMENTHAL F'OOD AND DRUG ADlUNISTRA'ITON i i HEAiISPHERE I'UBLtSHING CORPORATION Washington I Ncw York Londo • A HALSTED PRESS BOOIC JOHN WI LEY & SONS 'ork Ctdchcstcr Brisbane
Page 941: wrm95d00
S033S 3459 HITRITSS/ "` -_ --- - - - M4Mtb~ Rel~earck, 66 (1979) 149-158 TT II Re- 9 OSb..ier/Nortb-Hopan4 BiaasedkaiPre.a 3.P. NAOLICHI INUP•_, YOSHLSUKS N1SHr ', MASAI(O'PAK$TOklI ~ md KIKO MORI ~ . ~ Jostipe o/Ceq Biology and CytoEeneties, Blolotieal Research Ca~1s apan Tobacco and $oR 14blk Co.poration, ffatano, Kanapaws 257, and s Departrnatt of Experimental 1titAolop, Cancer Institute, Tokyo, Toskbno-ku, Tokyd 170 (Japan) (Raest.ed l9,Marcb 1978) (Raridon rqee{ved S September 1978) (Aoiapted 16 Septeaabs 1978) SUMary Hamster embryos were treated with various doses of NaNOs in utero, by its oral adminis4ration to the mothers, and then the embryonic cells were exam- ined for micronucleus formation, chromosomal aberratioas, morFhaiogical or malignant transformation and drug-resistant mutations.For induction of fNbtant mutations, the cells were cultured in normal medium for 72 h, and then selected in media containing 8-azaguanine (10 or 20 µg/ml) or 1 muNf 4S0 10 .0,02.6352 J~ "
Page 942: wrm95d00
0i Loeb, Leo, 1889- 331 y The biological basis of individuality, by Leo Loeb ... Springfield, Ill., Baltimore, Md., C. C. Thomas, 1945. zUl,Tiip.,11. 251 cno. ~ «lnrst edfuon." ; atDUo~ravn~ : D. 65i~esa. L Indhiduallty. 2. Traneplantation (Phlsfology) i. Title. QHKO1.L8 ~ 612.065 45-18 ~ Llbcary of Congress j52v1I 7""`"r
Page 943: wrm95d00
f '-- NA1'IOM / ~ 50335 3061 y! C; ICL'LTURE/ ~a~qC _ . C--ACR 75 VII Mo r RJR CLASS 140. PAtiPiiLET 75 VII Mo Morrison, J. E.; Jr.;"Milbocker, D. C.; Atkinson, W. 0.; Smiley, IT. H. (Univ. Ky., Lexi-tigton, Ky., U. S.) . ~ . Hortscience 8 (No. 6) 483-85'.(1973) (in English) *Keywords:* paraquat, tobacco, additive. . *1974, No. 24, W 9613* *d* Tobacco agriculture: . IT741FFW-14~cl P.-- p~a.a~p~:a3Qs4 ++,wF'.`~~< (
Page 944: wrm95d00
3.91 RJR CLASS NO. PAM1'HLET XX MeFA(1912) S.P. R. J. Reynolds Tobacco Co.,- Research and Product Development Departments, Science Information Division ADDITIVES, INGREDIENTS, INCLUDING UNDESIRABLE CONSTITUENTS AND OTHER. D._,ff2=9/f0XICITY OF FOOD ADDITIVES, by R. J. Reynolds Tobacco Co., Research and Product Development Departments, Science Information Division, and LeRoy Meek. 1972 A collection of material Winston-Salem, N. C. 7- -4- -4-
Page 945: wrm95d00
~ • ~ y } - - /~.N. AL _~.r"2;. (~rA(.°os:1. ...s..if.6.:._ RJR CLASS ::0. PAMPHLFT 72 X Un,; U. S. Department Health, Education, Welfare, Public Health Service, National Institute Occupational Safety Health, Health Services "!ental Health - Adair.istration, Division Technical Services, Roekville, M3., U. S. BEALT4 ASPECTS 0F S:'lOKI;1G IN U. S. Bep. Health, Educ., Wel are, Pub. ealth Serv., Nat. Inst. Occup. Safety Health, Health Serv. Mental Admin., Div. Tech. Serv., Rockville, Md., 85 p. (Dec. 1971) (in English) *1Ceywords:* amnonia, smoke, constituent; carbon monoxide, sr.*.oke, constituent; hydrocarbons, polynuclear, smoke, constituent; particulate matter, smoke, constituent. 0 5 C1 Q t1 .4 2 6 3 5 6
Page 946: wrm95d00
S `'"`- y REGULATIOrJ OF FOOD ADDITIVES AI;D MEDICATED ANIMAL FEEDS :. -WARINGS BEPORE A SUBC011:1IITI'EE 0F THE COlu;li.Irl i EE ON .~„~ GOVERNMENT OPERATIONS HOUSE - Or REPRESENTATIVES . NINETY-SECO\'D CONGRESS ?'IRST SESSION ' UARCH 16. 17, 18, 29, A\I) 3q 1971 Vi. GOYERNKENT PRI;lTING OFriCE 4 ~ rPA3RINGTON : 1971 >ot nl. bP LM Saprlntendent ot Docamenq. V.S. Oonrom.nt Prtatlus O:1c. Ilbhlnctoe. D.C. NHO2 • Pric.1't.7b
Page 947: wrm95d00
ISONING/ ~~a 74 ZX NeP-E~ili S.P. R. J. Reynolds Tobacco Co., Research and Product Development Departments, Science Information Division ANALYSIS, EVALUATION, REGO[11?ORT, HYGIENE. E01. FOOD POISONING, by t. J. Reynolds Tobacco Co., Research and Product Development Departments, Science Information Division, and LeRoy Meek. 1974 A collection of material Winston-Salem, N. C.
Page 948: wrm95d00
50335 3466 . :.• . . _ _ %.ECOLO(:ICAL RESEARCII 'SERIES/ f I~IR=-POLLUTION--ANALYSIS/AEROSOI.S--A°ASURT•.MENTS/nZONE/.FPA-600/3-76-018 i RA ~ February 1976 576 Sp 1976 by Chester W. Spicer, James L. Gemmna, Darrell W.•Joseph Philip R. Stricksel, and Gerald F. Ward BJITTELLE - Columbus Laboratories Columbus, Ohio 43201 Contract No. 68-02-1714 . Joseph J. Bufalini Gas 1Cinetics and Photochemistry Branch Environmehtal Sciences Research Laboratory Research Trianqle Park, North Carolina 27711 ~OFFICL OF" P~EARCH~~EVEIAPMENT S P.ESEARCH IAFOPATORY
Page 949: wrm95d00
Pierson, '[. D. 'CIP~ TRANSPfI$T OF `t".TitYL-a-'J-- Gi.ui.OP?RMltX,iui: uz THCRMB,LW S'TRI:SSF.D SAI' iD*:1.LIA TYP=tI'-tiJ.^.It)t, by :•&,. D. FiErson aiul Z. J. Ordzl Biochemicsl 6 aiophys. 'tes. C .o*~~mn. 43 (::o. 2) 378-383 (197:) 0 S Q QnQ:Z ~'! 3ss
Page 950: wrm95d00
DISSERTATIpNS--UNIYERSIIY OF J(INNESOTA/FOOD--CARCINOGENIC HAZARDS/ ~ C~ER--CAUSA?ION BY LFLATOgINS/AFLATOJCINS CANM116 to R"'RES EARCH / +' ~ 1971 ~'_~ ~=on~SIS AS A SOURCE OF COTOICINS IN MAN S FOOD CHAIN. - A Tft£SIS ~ ^ _ ---- t PDDL W=?!Za ''1'0 ?M Ft CULTY OF M GRAD7ASs SCHOOL ~ . i IlI pLR','IAL PL'L.FI'a.T:MM'T 0? T.IM !tEQJIRC'r.t"I1TS OF :HB ONIr-~+tSIrY oP bunit-b-4vTw T .. . .~.. . . •T - ~ .~; FOR T'S DFGRF.S C? • WCTOR QF BhIIASOFMY . • jai¢s, 1971 ... .r
Page 951: wrm95d00
50335 3072 TP 370 U• •I t • C:`._~.,..p r~. ..T, { ;. .. ..~ ~.t • _ .1ti'J. . ... ,. ~~~ 0 5 0 0 0 Q 2 5? 4 8
Page 952: wrm95d00
U. S. President's Science Advisory Ccc•imit:zee 11ANMiNG OF TOXICOLOGICAL i -W
Page 953: wrm95d00
/ ORNL-TIkC-73-9 lIX NeF-ROM-74. TOXICITY OF,~'~OTATOES : A BIBLIOGRAPHY ' . - -ebruary 1973'~ - _ _. 'Helen S. Warren - ~ ~ICICOLOGY INFORMATION RESPONSE CENTER Work supported by the Toxicology Information Program, 50335 3471 National Library of Medicine, National Institutes of Health, .•Department of Health, Education, and Welfare under NLM Interagency Agreement No. 40-274-71 OAK RIDGE NATIONAL LABORATORY Oak Ridge, Tennessee 37830 operated by UNION CARBIDE CORPORATION for the U. S. ATOMIC ENERGY CO"DiISSIOv Abstract ~ - - .. ~. . • --- 0 5 o 0 o a-.z• 5 747 f I
Page 954: wrm95d00
5033S 3479 . RA 1190 ile 1982 INFOItMATION RESOURCES IN TOXICOTAGY Phft wpckr
Page 955: wrm95d00
50335 3473 SERENDI?ITY BERRY/SYNTIIETIC SWkETENERSJF00D=-FLAVORANTS/TROPICAL PLANTS/ , LICORICE/GLYCYRRHI2IN/FLAVORANTS/TASTE--TESTINC/FRUCTOSE/GLUCOSE--IsONERASE/ SYRUPS CORN SENSES AND SENS.4TION/HONWMAPLE SYRUP/SACCHARIN/PROTEINS, PLANT/ *