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ENCLOSURE 1- Procedures for Managing and ProgrQss Monitoring of R.J. Reynolds Industries Support of Biomedical Resear.ch Manaaement - The following procedures govern the commitment of _._. _-J__.____~ funds to biomedical research and the role of various individuals and authorities in considering requests and granting approvals: • Requests f.or funding support will he referred to Dr. Frederick Seitz. • Dr. Seitz and other mEmbers of his advisory panel will review fund requests and prepare recommendations based on these criteria: * Project viability * Researcher's qualifications * Adequacy of facilities * Consistency with overall program objective • Prior to presentation to the Contributions Committee for disposition, Dr. Seitz will informally discuss recom- mendations with Mr. H.C. Roemer, general counsel. His comments will be appended to the written evaluations and recommendations presented to the Contributions Committee. Mr. Roemer would be free, of course, to consult outside counsel, such as Ed Jacob, as he deems necessary or desirable. e Twice each year, at the 2nd and 4th quarter meetings of the Contributions Committee, Dr. Seitz or a member of his panel will present funding requests and the panel's recommendations. Research targets of opportunity may be presented to the Committee at other times with the per- mission of the chairman. Dr. Seitz's presentation of each new request to the Committee will include: * Assessment of scientific merit * Recommended budget * Time frame of the project * Recommendation for or against approval • Contribution Committee gives approval or disapproves.

Program Monitorinq and Oversight - Program monitoring will be accomplished by means of written reports and si te visits. Written semi-annual reports frorn researchers will tx-, reviewed by the Director of Corporate-Contributions and be distributed to appropriate persons for review, comment or other action. The Director of Corporate Contributions will also establish and schedule a program of site visits by small delegations representing the Contributions Committee of the Board, the scientific advisory panel, inside and outside counsel and appropriate Industries executives. A site visit to each supported program will gen.:rally be scheduled once each year by a delegation of two or three persons. Following each site visit a report will be prepared by the delegation and furnished to the Director, Corporate Contribu- tions for appropriate distribution. Such reports will be made a part of the file for a particular project and will be used in preparing progress reports for the Contributions Committee of the Board. Persons scheduled for site visits will be drawn f rom the following: • Directors of Committee the corporation serving on the Contributions • Inside and outside counsel • Vice President and Group Director, Relations Corporate Public • Officers of subsidiary cumpanies as de5ignated by th~:- Chairman of the Contributions and Men bership Com,mitt-~e • Director, Corporate Contributions The Chairman and CEO, the President and the Vice Chairman of the, Board may, at their discretion, join the delegation in any site visit.