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CANCER DETECTION AND PREVENTION Address all editorial correspondence, including manu- scripts, to Herbert F.. Nieburgs, M.D., I)epartment of Pathology, Mt. Sinai School of Medicine, New York, New York 10029. Address all subscription orders, with payment, to Marcel I)ekker Journals, P. O. Box 11305, Church Street Station, New York, New York 10249. Address all change of address notices for the member- ship listing to The lnternational Study Group for the Detection and Prevention of Cancer, Mt. Sinai School of Medicine, New York, New York 10029. Address other inquiries to the office of the Publisher: Marcel Dekker, Inc., 270 Madison Avenue, New York, New York 10016. The subscription rate for Volume 3 (1980), containing two numbers, is $35.00 prepaid. The special discounted rate for individual professionals and students is $17.50 per volume. To secure this special rate, your order must be prepaid by personal check. Add $3.70 per volume for postage outside the United States. Copyright © 1980 by Marcel Dekker, Inc. All rights reserved. Neither this work nor any part may be repro- duced or transmitted in any form or by any means, electronic or mechanical, including photocopying, micro- filming, and recording, or by any information storage and retrieval system without permission in writing from the publisher. Printed in the United States of America. Contributions to this journal are published free of charge.

The International Society for Preventive Oncology, Inc. - EDITOR-IN-CHIEF Herbert E. Nieburgs Department of Pathology, Jl1t. Sinai School of Medicine of the City University of New York, New York 10029 ASSISTANT EDITOR S. A. Kay EDITORIAL BOARD Richard R. Bates Henry Colcher M. M. Copeland E. Cuyler Hammond Ronald B. Iierberman Kingsley K. Kay Paul M. Newberne A. J. Phillips (Canada) Franco Rilke (Italy) Jeffrey Schlom Albert Segaloff Leon M. Shabad (USSR) Philip Strax Lorenzo Tomatis (IARC) Victor E. Valli (Canada) Umberto Veronesi (Italy) MARCEL DEKKER, INC., New York and Basel

3 London, F,ngland July 26 - 31, 1980 Sponsors: The Royal Society of Medicine The International Society for Preventive Oncology, Inc. (ISPO) Co-sponsor: The Page & William Black Post-Graduate School of Medicine of the Mount Sinai School of Medicine of the City University of New York, Neu York, New York, U.S.A. President of the Symposium: The Lord Smith of Marlow Vice Presidents: Sir Richard Doll Mrs. Albert D. Lasker Symposium Advisors: N. Berlin (U.I.A.) The Earl of L4alsbury The Lord Pdrritt P. Strax (U.S.A.) The Lord iuckerman G. Zubrod (U.S.A.) 0 PROGRAM COMMITTEE Chairman: H.F.. Nieburgs (U.S.A.) G. Bennette (U.K.) R.L.. Clark (U.S.A.) H. Colcher (U.S.A.) M.M. Copeland (U.S.A.) %A'. Davis (IARC) R. Flamant (France) J.F. Fraumeni (U.S.A.) S.A. Geller (U.S.A.) R.M. Hicks (U.K.) J. Husband (U.K.) Members: P1.1. L.innett (U.K.) Pt. Moore (U.K.) B.C. Morson (U.K.) G. NeHell (U.S.A.) G.T. O'Conor (U.S.A.) F. Rauscher (U.S.A.) D. Schmahl (Germany) R.A. Se1lNood (U.K.) L.H. Sobin (N'HO) V.E.O. Valli (Canada) U. Veronesi (Italy) U.K. LIAISON COMMITTEE Chairman: J. I. Burn, Royal Society of Medicine Members: K. BagshaH•e, Cancer Research Campaign L.M. Franks, Imperial Cancer Research Fund R. HeNitt, Royal Society of Medicine R.M. Hicks, Middlesex Hospital V.R. McCready, Royal Marsden Hospital M. Moore, British Association of Cancer Research P.A.B. Raffle, Royal Society of Medicine R.H'. Raven, The Marie Curie Memorial Foundation R.N. Thomson, Royal Society of Medicine I

This is a special issue of C'ancer Detection and Prerentlon. Volume 3, Number 1, 1980

INTERNATIONAL SCIENTIFIC ADVISORY COMMITTEE Chairman: R.W. Raven, FRCS. Members: S. Ahmad (Libya) O. Bjarnason (Iceland) D. Burkitt (UK) E. Caceres (Peru) A. Canonico (Argentina) 0. Capella (Spain) R.L. Clark (USA) J. Clemmesen (Denmark) H.N. Cooper (Liberia) P. Correa (USA) O. Costachel (Romania) D. Crowther (UK) S.F. al-Damluji (Iraq) J.A. Dickerson (UK) S. Eckhardt (Hungary) T. Elicano, Jr. (Philippines) C. Escalante (El Salvador) G. Friedell (USA) J. Sampaio Goes (Brasil) R.A. Good (USA) R.B. Gorbon (Turkey) V. Griffiths (Malta) K.E. Halnan (UK) I.W.F. Hanham (UK) T. Hirayama (Japan) Ho-Kei Ma(Hong Kong) H. Holzner (Austria) H. Kasdorf (Uruguay) N.M. Kazi (Abu Dhabi) R.A. Kolthoum (Dubai) W.S. Lowry (N. Ireland) J.P. Mach (Switzerland) H.E. Maisin (Belgium) I. Martinez (Puerto Rico) D. Metcalf (Australia) P. Morgado Mieves (Venezuela) A.B. Miller (Canada) G. Milton (Australia) A. Mojtabi (Iran) J.F. Murray (South Africa) H. Mustin (Mauritius) E. Nanson (New Zealand) A. Munro Neville (UK) F. Nkrumah (Ghana) T. Norin (Kenya) N. Mourali (Tunisia) M. O'Halloran (Ireland) Y. Omar (Kuwait) K. Oota (Japan) F. Prochnow (Hungary) K. Qassab (Iraq) A. Rahim (Bangladesh) F. Rilke (Italy) A. Riyami (Sultanate of Oman) F.J.C. Roe (UK) M. Garcia-Sainz (Mexico) P.A. Salem (Lebanon) F. Samarrae (Iraq) 1.. Santi (Italy) W. Schlipkoter (W. Germany) I.J. Selikoff (USA) K. Shanmugaratnan (Singapore) H. Skeete (Barbados) J. Svoboda (Czechoslovakia) H.J. Tagnon (Belgium) S. Tanneberger (G.D.R.) 0. de The (France) N. Trainin (Israel) N.N. Trapeschnikoff (USSR) M. Tubiana (France) V.E.O. Valli (Canada) D. van Bekkum (Netherlands) M. van Rysselberghe (Chile) A.O. Williams (Nigeria) M. Woodruff (UK) H. Wrba (Austria) H. Yaqin (Pakistan) iv

CANCER DETECTION AND PREVENTION, 3(1), v (1980) II)IIdR'S NOQ'E This special issue of the jounial is devoted to the scientific program of The Fourth International Synposium on Prevention and Detection of Cancer, in London, July 26-31, 1980. The abstracts of the papers presented in the Conferences, Panels, Syng)osia, Poster Sessions, Workshops and Courses, are arranged according to subject mtter. A total of 548 abstracts provide extensive overview and reference material of current progress in primary and secondary prevention. Included topics range frcm etiologic factors and control measures to biologic mani- festations, detection of occult carcincma in individuals at high risk, social issues in cancer control, mass screening, detection and diagnosis in specific sites, immuioprevention, and a new look at cancer. For those attending the Symposium, daily sessions are in numerical sequence; presentations listed by session are cross-indexed with abstract numbers; the abstracts are cross-referenced with session numbexs. The program schedule avoids conflicts and provides a sequence of sessions on similar topics throughout the Symposium. I am greatly indebted to members of the Program Ccnmittee for their choice of topics and speakers and to contributing authors for their enthu- siastic response to the call for abstracts. I am particularly grateful to Doctors Steven Geller, Franco Rilke, Philip Strax and Ted Valli for their help in reviewing and arranging the abstracts in the order in which they are presented in this volume. Last but not least, the production of this volume would not have been possible without the oooperation of Mr. Maroel Dekker and the outstanding editorial assistance of Ms. Suzanne Kay, Ms. Iris Accordino and Ms. Hannah Scherer. I very much hope that the reader will enjoy the use of this volume as much as the few of us who prepared it. H.E. Nieburgs, M.D. Editor-in-Chief V ~ 0 0 a r J N ,3D r

Around Wembley Complex By Bus 83,92 Et 182 come to Wembley Arena 18 comes to the Triangte. 5 mins walk Other usefut buses are: 297 (alight at Wembtey park Stn) 245 (alight at Bridge Road) Wembley Conference Centre (Wembley Grand Hall) Wembley Complex BR Station

CONTINUING MEDICAL EDUCATION CREDIT HOURS As an organization accredited for continuing medical education, The Page and William Black Post- Graduate School of Medicine of the Mount Sinai School of Medicine (CUNY) certifies that this conti- nuing medical education offering meets the criteria for 30%: credit hours in Category I of the Physicians' Recognition Award of the American Medical Association, provided it is used and completed as designed. You will be entitled to additional credit hours, awarded on an hour for hour basis, for atten- dance at Courses and Workshops. PROGRAM ACTIVITIES Meeting Site: Wembley Conference Centre, London Inaugural Ceremony: Saturday, July 26 at 6:00 pm, Grosvenor House Park Lane Closing Ceremony: Wednesday, July 30 at 5:00 pm, Grand Hall Scientific Sessions: July 27: 10:00 am to 6:30 pm July 28: 9:00 am to 6:30 pm July 29: 9:00 am to 6:30 pm July 30: 9:00 am to 5:00 pm Courses &. Workshops: July 30: 2:00 pm to 5:00 pm July31:9:00amto5:00pm August 1: 9:00 am to 5:00 pm Roundtable Luncheon July 27, 28, 29, 30 Discussions: 1:00 pm to 2:30 pm Films, Scientific Exhibits and Poster Presentations: Daily. Transportation: Buses will depart on a regular schedule between Symposium Hotels and Wembley Conference Centre. Official Language: English.

THE SYMPOSIUM TIMETABLE AVON 3 SEVERN I SEVERN 2 SUNDAY 1. OCCUPATIONAL 2. BIOLOGICAL 3. MASS 4. HEAD & NECK 6. NUTRITION 10:00 CARCINOGENESIS MARKERS SCREENING CANCER Symposium -11:30 Conference Panel Symposium I 'Panel 11:30 I ! I 5. HEAD 8 NECK ' -13:00 + j + CANCE R + *Symposium 15:00 7. CARCINOGENIC 8. BIOLOGICAL 9. MASS 11. BREAST 12. CANCER OF -16:45 FACTORS MARKERS SCREENING CANCER UPPER GASTRO- Conference Symposium *Symposium fl Panel INTESTINAL I ' TRACT 17:00 I I 10. CANCER PREV. I Panel -18:30 111 iii DEV. COUNTRIE S + 'Panel MONDAY 13. GENETIC AND 14. BIOLOGICAL 15. STRESS 16. BREAST: PROG- 18. GASTRO- 9:00 ENVIRONMENTAL MARKERS Symposium NOSTIC FACTORS ENTEROLOGY -10:45 INTERACTIONS Symposium *Symposium *Symposium Conference 11:00 ~ 17. BREAST: 19. PANCREATIC -12:45 ~ HORMONES CANCER *Symposium 'Panel 14:00 20. DIET AND 21. SYSTEMIC MA- 22. SQUAMOUS 24. BREAST: BIOL- 26. LYMPHOMAS AND -15:45 CANCER NIFESTATIONS LESIONS, FEMALE OGIC MARKERS LEUKEMIA Conference Symposium GEN, TR. 'Panel *Symposium *Symposium 16:00 I ~ 23. IMAGING 25. BREAST: MASS 27. LYMPHOMAS AND -17:45 1 'Panel SCREENING LEUKEMIA *Symposium •Panel UESDAY 28. DETECTION OF 29. CARCINOGENIC 30. SOCIAL 31. BREAST: 32. GENITO-URINARY 9:00 PRECLINICAL FACTORS RESEARCH AND IMAGING TRACT CANCER -10.45 CANCER Symposium PUBLIC Symposium 'Pane/I Conference EDUCATION Panel 11:00 ~ 33. GENITO-URINARY -12.45 1 TRACT CANCER •Panel 11 14:00 34. PROMISING 35. EXPERIMENTAL 36. EDUCATION 37. IMMUNOLOGY 38. COLO-RECTAL -15:45 TECHNIQUES CARCINOGENESIS AND AND VIROLOGY CANCER OF DETECTION RELEVANT TO REGISTRIES Symposium •Panel Conference CLINICAL Symposium 16:00 ONCOLOGY I + 39. COLO-RECTAL: -17.-00 ~ Panel 1 i ETIOLOGY & DIAG. •Symposium WNSDAY 40. A NEW LOOK 41. OCCUPATIONAL 42. CERVIX: RISK 44. PREVENTION 46. COLO-RECTAL: 9:00 AT CANCER CARCINOGENESIS FACTORS, HIS- OF METASTASIS SCREENING AND -10:45 Conference Symposium TOLOGY *Symposium MANAGEMENT 'Symposium Symposium 11:00 ~ 43. CERVIX: 45. RESPIRATORY J -72.-45 J SCREENING TRACT CANCER *Symposium 'Panel 14:00 47. SOCIAL 48. CARCINO- 49. FEMALE 50. RESPIRATORY 51. IMMUNO- -17:00 ISSUES & CAN- GENESIS GENITAL TRACT CANCER PREVENTION CER CONTROL Symposium - TRACT CANCER Symposium Symposium Conference Symposium 17:00 CLOSING CEREMONIES POSTER SESSIONS: 52-61, Sunday, Monday 62-68, Tuesday, Wednesday