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i NOTE A Cardiac Life Support System will be in operation dur- ing the Annual Scientific Sessions Program. This will be a functional unit for stabilizing life threat- ening emergencies that may occur in the meeting hall. The Life Support System will be located near the Ex- hibitors' Service Desk. All Security Guards, Exhibitors and Sessions Modera- tors can activate the system. AMA CREDIT: This Continuing Medical Education of- fering meets the criteria for 22 hours of credit in Cate- gory 1 for the "Physician's Recognition Award of the American Medical Association." This would include at- tendance at all sessions including the two evening pro- grams. Partial participation can be credited for one unit per hour of attendance. Please notify your State or National AMA Office. NOTE: A CERTIFICATE OF AT- TENDANCE CARD IS AVAILABLE AT THE REGISTRA- TION DESK FOR YOUR RECORDS. A program of social activities has been planned for men, women, and children attending the Annual As- sembly. Information is available at the Hospitality Desk in the foyer of the Regency Ballroom at the Fair- mont Hotel. 52nd Scientific Sessions November 12-13, 1979 Dallas Convention Center Anaheim, California

AMERICAN HEART ASSOCIATION PRESIDENT'S MESSAGE On the occasion of the 51st Annual Scientific Ses- sions of the American Heart Association, I would like to welcome you all to this impressive forum'of infor- mational exchange concerning the cardiovascular sys- tem in health and disease. For the past 30 years the American Heart Association as a nonprofit voluntary health agency has had as its goal the conquering of diseases of the heart and circulation by means of re- search, prevention, and education of both the profes- sionally involved and the lay public. The Scientific Ses- sions are an indispensable means by which the fruits of our members' research are made known to the pro- fessional sector. Participation in this continuing tradition of scholarly presentations has been increasing yearly, which serves to indicate the effectiveness of the Scientific Sessions as a vehicle for dissemination of our current knowledge of the heart and blood vessels. This year the number of abstracts submitted for presentation totaled 2967, an increase of almost 1000 from the number submitted just three years ago. It is unfortu- nate that temporal limitations allow acceptance of only 991 of these fine examples of responsible scientific investigation, which illustrate both the high quality of the investigators involved and the equilibrium be- tween basic research and clinical analysis that the As- sociation strives to maintain. This high quality of our membership-and particularly the outstanding scholarship of our young investigators-is also well illustrated by the several other facets of the Scientific Sessions, such as the 7 Clinical Sessions, 7 Cardiovas- cular Conferences, 22 "How To" Sessions, 11 Post- graduate Seminars, 22 Scientific Exhibits, and the 3rd National Conference on Thrombosis and Hemostasis. We are fortunate this year, as we have been in the ~ past, in having some very distinguished guest speak- n h ers. Dr. Henry N. Wagner, Jr., of Johns Hopkins N School of Hygiene, will deliver the Lewis A. Connor M Memorial Lecture, speaking on the development and (~ applications of radio isotopogra phy in the diagnosis of 0 cardiovascular disease. The International Lecture will. be delivered by Dr. Wilfred G. Bigelow of the University

Y AMERICAN HEART ASSOCIATION OFFICERS Honorable Richard H. C. Taylor Chairman, Board of Dlrectora Harriet P. Dustan Immediate Past Presidonl

i of Toronto, who will critically review heart surgery, past, present, and future. Among us this week in Dallas are physicians, basic scientists, nurses, and allied health professionals; planning a balanced presentation for such a diverse audience is certainly not an easy task, and the 24 members of the Committee on Scientific Sessions, headed by Dr. Lawrence S. Cohen, merit special thanks for their diligence and circumspection in pro- viding us with a program appea1ing to all. I find it particularly fitting that we are convening this year in the city that is also the new national headquar- ters for the American Heart Association. The national organization is strong and stable, and its future in Dal- las is bright. At this time I would like to reaffirm my conviction that the American Heart Association throughout the country is equally strong and stable, and its future equally bright! W. Gerald Austen, M.D. President American Heart Association 1977-1978 .

PAST PRESIDENTS OF THE AMERICAN HEART ASSOCIATION 1924-25 Lewis A. Conner 1925-26 Joseph Sailer 1927-28 James B. Herrick 1929-30 William H. Robey 1931-32 Robert H. Halsey 1933-34 Stewart R. Roberts 1935-36 John Wyckoff 1937-38 William J. Kerr 1939-40 William D. Stroud 1941-42 Paul D. White 1943-44 Roy W. Scott 1945-46 Annual Meeting Cancelled. , Officers Retained 1946-47 Howard F. West 1947-48 Arlie R. Barnes 1949-49 Tinsley R. Harrison 1949-50 H. M. Marvin 1950-51 Howard B. Sprague 1951-52 Louis N. Katz 1952-53 Irving S. Wright 1953-54 Robert L. King 1954-55 E. Cowles Andrus 1955-56 Irvine H. Page 1956-57 Edgar V. Allen 1957-58 Robert W. Wilkins 1958-59 Francis L. Chamberlain 1959-60 A. Carlton Ernstene 1960-61 Oglesby Paul 1961-62 J. Scott Butterworth 1962-63 James V. Warren 1963-64 John J. Sampson 1964-65 Carleton B. Chapman 1965-66 Helen B. Taussig 1966-67 Lewis E. January 1967-68 Jess E. Edwards 1968-69 Walter B. Frommeyer, Jr. 1969-70 W. Proctor Harvey 1970-71 William W. L. Glenn 1971-72 J. Willis Hurst 1972-73 Paul N. Yu 1973-74 Richard S. Ross 1974-75 Elliot Rapaport 1975-76 John T. Shepherd 1976-77 Harriet P. Dustan 1977-78 W. Gerald Austen ~ 0 0 N C1 A

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IS MONDAY AFTERNOON, NOVEMBER 13 3rd NATIONAL CONFERENCE ON THROMBOSIS & HEMOSTASIS Plenary Session: Current Concepts of Arachidonic Acid Oxygenation in Thrombosis ........ 26 Plenary Session: Prostacyclin in Thrombosis and Atherosclerosis ............................ 27 CLINICAL SESSION I I ............................................... 50 Symposium: Clinical Evaluation of Ventricular Arrhythmias in Chronic Ischemic Heart Disease Symposium: Management of Ventricular Arrhythmias in Chronic Ischemic Heart Disease Cardiovascular Surgery: Surgery for Coronary Artery Disease I ..................................... 51 Basic Research: Pharmacology I ..... * 52 Clinical Research: Valvular Heart, Myocardial and Pericardial Disease/Infective Endocarditis .:..........................„ 53 Cardiovascular Radiology: Coronary Artery & Aortic Disease ......................................... 54 Clinical Research: Ventricular Function/Hemodynamics I .................................... 55 Epidemiology ............................................................ 56 Louis N. Katz Basic Science Research Prize Session ........................................................ 57 Basic Research: Myocardial Mechanics ..................... 58 Basic Research: Experimental Myocardial Infarction I ............................................................ 59 Arteriosclerosis: Lipoprotein Metabolism II ................ 60 ~ ~ ~ N I POSTER PRESENTATIONS Clinical Research: Echocardiography & Ultrasound I ............................... ................ 61 Boards P1-P8 Clinical Research: Echocardiography & Ultrasound I I ..................................................... 62 Boards P9-P21 Cardiovascular Disease in the Young: Congenital Heart Disease I .................................... 63 Boards P16-P19 Basic Research: Electrophysiology I .......................... 64 Boards P20-P31 Clinical Research: Pacing .......................................... 65 Boards P32-P35 Clinical Research: ECG/Dysrhythmias ....................... 66 Boards P36-P39 Arteriosclerosis: Risk Factors .................................... 67 Boards P41-P43 Cardiovascular Disease in the Young: Echocardiography .................................................. 68 Boards P45-P48 Cardiovascular Radiology: Echocardiography ............. 69 B oards P49-P52 Basic Research: Cellular Biology I ............................. 70 Boards P53-P60 Basic Research: Myocardial Metabolism .................... 71 Boards P61-P64 3

r<.CNERAE INFORMATION BUS SCHEDULE: Operates approximately rp 20 minutes. Mon day: ,t3 to Convention Center 7:00 a.m. to 11:00 p.m. Tuesday: vc't to Convention Center 7:30 a.m. to 6:00 p.m. Pct to Fairmont Hotel 6:00 p.m. to 11:30 p.m. Wednesday: ,rt to Convention Center 7:30 a.m. to 11:00 p.m. Thursday: ~t to Convention Center 7:30 a.m. to 1:00 p.m. E:~t of shuttle bus routes will be sent to advance trtnts, and can also be found at the back of this I*- EXHIBIT HOURS *rsd9y, November 13 ......... 8:00 a.m. to 5:30 p.m. sday, November 14 ......... 8:00 a.m. to 5:30 p.m. rincsday, November 15 .... 8:00 a.m. to 5:30 p.m. ttu*t.day, November 16 ..... 8:00 a.m. to 12:30 p.m. Xti1BITS: Intermissions have been scheduled simul- -rously on Monday, Tuesday, and Wednesday from 15 10:45 a.m. and 3:15-3:45 p.m., and on Thurs- ~ from 10:15-10:45 a.m. to facilitate visiting the ~antthc and industrial Exhibits in the Convention ter. 13

M MA-LO-_ >7 : a, / WEDNESDAY MORNING, NOVEMBER 15 . WEDNESDAY AFTERNOON, NOVEMBER 15 CLINICAL SESSION VI .....................•........................153 Lecture; An Overview of Infective Endocarditis: The Changing Clinical Spectrum Lecture: Indications for Pacemaker Insertion in Chronic Rhythm Disorders Lecture: Complications of Permanent Pacemakers Lecture: Medical and Surgical Treatment of Aortic Dissection Lecture: Management of Acute Hypertensive Emergencies Lecture: Diagnosis and Management of Intermittent Claudication Clinical Research: Echocardiography & Ultrasound III ........................................................154 Cardiovascular Surgery: Surgery for Valvular Heart Disease I I ....................................................155 Clinical Research: Chronic Ischemic Heart Disease IV .............................................................156 Clinical Research: ECG/Dysrhythmias 11 ................... 157 Clinical Research: Exercise/Exercise _ . ~• :,_,:,..,_ ~~ Testingircenaoit~~e~~~~~ . ........ ............... 158 Cardiovascular Disease in the Young II: Acquired Heart Disease and Echocardiography ..................................................159 Community Programs ...............................................160 Scientific Sessions for Nurses: How-To Sessions ...................................................161 Thrombosis: Clinical Thromboembolism II ................162 Thrombosis: Coagulation II .......................................163 High Blood Pressure Research: Renal . and Vascular .........................................................164 Renal: Basic & Clinical ..............................................165 Cardiovascular Nursing Research .............................166 Thrombosis: Platelets II/Activation - Secretion Coupling ................................................167 Arteriosclerosis/Thrombosis: Thrombosis and Atherogenesis .......................................................168 POSTER PRESENTATIONS Cardiopulmonary: Ventricular Function .....................169 Boards P1-P4 Clinical Research: Ventricular Function/Herriodynamics 11 ...................................170 Boards P5-P8 Basic Research: Ventricular Function II ....................171 Basic Research: Systolic Ventricular Function ...........172 .Boards P13-P16 Thrombosis: Platelets/Coagulation ...........................173 Boards P17-P20 Thrombosis: Platelets/Surface Reactions ...:..............174 Boards P21-P28 Clinical Research: Valvular Heart, Myocardial and Pericardial Disease/Infective Endocarditis I I .......................................................175 Boards P29•P36 Clinical Research: Valvular Heart, Myocardial . and Pericardial Disease/Infective Endocarditis I I I .....................................................176 Boards P37-P40 P45-P48 9

/ TUESDAY AFTERNOON, NOVEMBER 14 CLINICAL SESSION IV ......... .., ~ SvmDosium: Non-invaci,,A : '""a [srd,ovascuJar Radiology: Isotope Ima8ing .••.••......•..120 "rss Pl •P4 pn<at Research: Isotope Imaging III ...•......•....,,,,,,,,121 1•..ijwds P5•P12 C,S,n.ca1 Research: Chronic Ischemic wsrt Disease 1 .....................................................122 t,.•strds P13-P20 c3encat Research: Chronic Ischemic KcsR Disease It ....................................................123 lt.aan,'s P21 •P24 inrna,basis: Coagulation Biochemistry ..................... 124 (..~u~css P25.P28 ii+rwnbosis: Coagulation Heparin ......................•...,,,125 #t.a*Cs P29~P32 Trrtxnbosis: Ptate(ets/Biochemistry ......................... 126 RaaKis P33-P36 (1^cst Research: Exercise/Exercise Test&ng/Rehabilitation II .................. ,.................... 127 r.,4rJs P37•P40 Arr.r+osclerosis: Lipids ................ .............................. 128 ftwds P41•P44 re,Kf, Blood Pressure Research ................................. 131 feth Blood Pressure Research: C,-nverting Enzyme ...............................................132 Ca•d.ovascufar Radiology .......................................... 133 A:ltrnergic Function ..............................................130 Crr+ual Research: Exercise/Exercise TFStin,Q/Rehabilitation lil ...................................... 129 ot,gh ptood Pressure Research: . 7