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, ° ,- ° ROYAL : oI"rAWA HOSPITAL HOPITAL ROYAL D'OI-i'AWA ;*- . - ., .° . ° 7 [o, ." °. Dr. V,J. Kno~t, Speciality Cllnics. 1145 CARLING. OTTAWA, ONTARIO KIZ 7K4 TEL. 613/722-6321 November 23, 1981. Canadian Tobacco Manufacturers Council, 1808 Sherbrooke St. West, Montreal, Quebec, H3H 1ES. Dear CTMC Members, In November of 1979, I proposed that CTNC fundinz of my research be extended for an additional five year period so that I could further my work on stress-reduction aspects of tobacco smoking. Attached is a copy of the brief proposals which I considered to be o~ critical relevance to the motivstional understanding of the smoking habit. Of the projects suggested, the lon~itudinal study ( which involved Year I0 Year II and Year V) was considered to be of greatest potential in elucid~tin~ motivational mechanisms. Attached is a research proposal which proviaes, in addition to methodolo~, the theory, rationale, fr~,~cwork and significance of this study. Specific details re<ardinc delails of the methodology have purposely been left out so as to allow the CTMC members a clear scope of the general procedures without distraction by a myriad of detail. If however, specific details of tests, re~arding procedures etc. are required, this can be done on request. Attached also is a list of budget requests and Zheir rationale. My greatest concern and embarrassment here is with the &mount of monies requested az it is the larges: budge~ (~89,789.00) I have requested to da~e. The greatest need of course is technical assistance. I am in the laboratory from 9,00 a.m. - 5:00 p.m. and as such reading, summarizing and .writing reports and papers is exzremely difficult. An additio- nal member, at the technical level, would definitely relieve• the pressure. The rationale for the additional requests is attached so I will not elaborate here. The large reauest of course pertains only to Year I of the five year plan. The 2nd to 5th year budget requests will be greatly reduced as these will only involve the two salaries and approximately $10,O00/year. C~ BatCo document for PFSFC 1 March 1999

• °.. 4~ - . • .°°'" As observed in the additional proposals, the purpose of ~he protocols in Year III ~nd Year IV are t Year III, To determine whether the phyziological, behavioral and psychological symptoms experienced during tobacco abstinence are indicative of a "return to an endurin~ . psychophysiolo~ical makeup" or are indicative of a temporary "withdrawal syndrome". Yeaz'IV= To determine whether tobacco smoking alleviates attentionsLl deficits in psychia- tric patients exhibiting such ,disorders in the extreme (eg. anxiety patients, schizo- phrenics etc.) The written proposals for each of these stud'ies will be submitted prior to each specific deadline date. Thank you for your consideration of this research. Your support and interest in my work over the past four years is ~reatly appreciated, Yours Sincerely, I' • .• Verner J. FJ~ot¢, D.Phil. • o I • : i l I ! | ! F t: :°- ! t f | t• j 0 Oo "---d BatCo document for PFSFC 1 March 1999

° - "" i, f " ",'-°" .... T : : Rationale for Budget Requests, Year I, Jan_~82 - Dec/82. This budget is the largest ($85,789.00) I have requested ¢o date and although I have tried to be very conservative in my needs and expenditures for this longitudinal study, the first phase (Year Z) just necessitates more staff and equipment if a high quality product is desired in the fifth year, Salaries, .Principal Investi£ators The salary request here is in lane with the updated salaries of the ROK. For a Registered Psychologist in the province of Ontario, the be~innin~ salary is $30,478.00 and the yearly increment is $1,378.O0. As I now have 4 years of experience, the salary level is $35,990.00. As CTMC kindly added additional monies to cover my benefits last year, I included this 10% with assumption of course that this is purely optional to CTMC. Research Technician, Two full-time research technicians are required for assistance in this study. One technician is needed in the laboratory in assisting psychophysiological recordings and a second technician is required in assisting, initiating and maintaining sample records, and for codin~, storin~ and analysing of data. As two full time salaries at a technical level is a heavy expense, I have decided to take on only one full time technician for psychophysiological records and to spend less than half of the amount of the salary (to be used for a second technician) in hiring a part-time computer programmer to develop the software capacity of the micro- processor in the laboratory so that it can take over the major work and time involved in coding, storin~ and analysing data. At the ROH, a full-time psycho-technician starts at $14,382.OO with yearly increments of $?30.00. As the technician I have in mind already has 9 months of relevant experience elsewhere and will be available for a full-time position in January, a salary of $15,000 would be appropriate for this position. Salary for a computer programmer on a part-time contract is estimated to run at $7,000.00. It should be made clear here, that the salary for this part-time position would only be required for one year and it would then terminate. Major Equip: At present my Beckman polygraph houses four amplifiers and this simply means I can only record 4 measures. To go into a longitudinal study of such potential with this restricted number of physiological measures would be a catastrophe and it is proposed here that we at least double the number of amplifiers to eight~ As Beckman prices have greatly increased CXD o. BatCo document for PFSFC 1 March 1999

° with inflation etc. (i.e. to purchase 4 additional amplifiers and associated couplers from Beckman would ~cost approximately $10,000.00} I intend to purchase 4 separate stand-alone amplifiers of similar quality which are compatible with my microprocessor's A-D converter but are much less expensive than Beckman, the price of these is $6,000.00. In order to carry out some of the sophisticated data acquisition and analysis of "attentional" and "cognitive" components of brain event related potentials, specific physiological filters are required to get rid of unwanted electrical noise in order to examine the extremely small but significant brain responses. The price of these 4 filters is $4,000.00. Up to this point I have been presenting auditory stimuli via an external tone generator which is triggered .by.the microprocessor. This has faltered several times and has required repairs, probably because of its a~e. In addition, in order to elicit specific brain potentials, high quality control over auditory stimulus characteristics (eg. frequency, duration, intervals, rise and decay time etc.) and this necessitates a new sould generator which incorporates these facets. The price of this is $2,500.00. The impedance meter is required to ensure that electrode- skin resistance levels are at a sufficiently low level so as to ottain clean noise-free electrical responses. The price of this is $300.00. Supplies: The polygraph paper, ink and electrodes ($i,500.00) are of course self-explanatory and the computer disks ($2,000.00) are necessary for data storage. Subject Payment, The biggest strategic problem facin~ this investigation is gettin~ the family (both the parent for the interview and the child for the recording) motivated to be involved in the study. From past experience and in relating to researchers who have done research within the school system, monetary payment definitely enhances this probability. It • is proposed here that a minimum of $I0,00.00 be paid to each as both parent and child will devote two hours of his or her time. Total cost is $6,000.00. Miscellaneaous: Published questionnaires on personality and psychological tests mus~ be purchased and the cost is estimated to be $I,000.00. Mail is an essential process if contact is to ~e maintained with the sample pool and the cost here is estimated at $I00.00. Filing cabinets are needed for physical C:D 0-, C~ BatCo document for PFSFC 1 March 1999

• . .. . -° ..... _A i storage of the questionnaires, polyEraph paper etc. ($600.00)! A calculator is needed for mtnor descriptive tests and assistance within the lab (cost is $200.00). ~, and as stated In the covering leter, I am aware that th~s is a large financial request but I trust that CT~C will keep in mind that this holds only for the demands of the first year of the 5 year grant. The financial con,nittment for the 2nd to the 5th years will be similar tnnature to what was being requested in my lass ~ years, i.e. monies for salary (In ~his case 2 salariess the principal investigator and technician)'and approximately $10,000.00 extra for laboratory demands. °. ! O °. • .°.. BatCo document for PFSFC 1 March t999

• ° i = - - • .'= . ° o - . . Budge% Requestst YearlIt_~Jan~1982 - Dec/I~82 Salaries, Dr. Y. Knott (plus 10~ for benef£¢ coverage) Research Technician Sol%ware Development $15,000.00 7,O00.00 Equipmentt Physiological Amplifiers PhysioloEical F£1ters Stimulators Impedance ~e%er 6,000.00 ~,000.00 .2,500.00 300.00 SuDDliest Polygraph paper, ink, electrodes Computer Disks Z,500.O0 2,000.00 ° • °.. ! Ten doZlars~ subject and Ten dollars/ parent interview 6,000,00 Miscellaneous, Questionnaires Bail Filing Cabine%s Calculator Total 1,000.00 100.00 600.00 200.00 $85,789.00 ! P ... ! C3~ L.,,,4 BatCo document for PFSFC 1 March 1999

.i °. ROYAl. OTTAWA IIOSi'IFAI. HOi'ITAI- ROYAl- O'OTTAWA - Dr. V.J, i:n,~tt,• 5poolallty C] inicn 1145 CARTING, OTTAWA, ONTARIO KtZ 7K4 TEL. 613.';'22-S521 i;ovember 11. 1979. .• °. '~.h~.".':cienLLrit" 1. iLeratun: "h~ con.nL~tently r.-,Lnc, d number of'(tuo.=ti3n..., in reference to .ratter',-, which both relate 1;o thc acquL.-i, ti,)'~ rye! ~,nLntenw~ce of smokLnr, behavior. Tt Is my ,'trent h,.,1.ief bane,I on my o~m lnboratory findinKs and ,~.l;ud~e~ of "':uropo;a,•l, ~r~ti,~h and Amer~c:~l laboratoriec, that the ~aechani::m:: ,m,lcrty~nF. ncq:~i,J;_tion-mRintonance processes nre in p~rt h;'u,e,~ on the inherent or intrinsic p%,cho- phycLolo~Lc~t "~u'=cu? of the indLv;-du.~~ croaker, fZore" ."necifi.coll..y, ~t L~ ;"~.t.hizl rearon to speculate ~h.~'c .~,nokers, prio.- to n :'m.~:',h~." h~rtory, exhJ.b~.4; n p~,chophyr~oloFicnl nrof~.l.n ~':hi.ch, rnl.nLiv.: to future non-nmokers, J.~ charncl:- C,'J.~.~.!d ),y n rr:'~.".t'Tr vtll.t|ec-ab~lity tO ~;~;re.~.-. ~.-, refl.ected ~n cPntrnt, n'Jt,~,l't~ke m'~d skolct,~l-musculnr ~ystens m~d R d~.f~c~cnt hchnvEnrat recponsiv~ty as reftected £n attentionRl ~Ln?O-.~', t| ~tt-,,,',)f'~.'='=inr ::n,! decicLon makinr functionn. "It)1%!!.~. "l~,;,"l" [nhqrent1~' e=tn':)~i=hed, the enoc'mo'Js :~t*,.,'~cl~.~n oF t~,:ncro I~c in it.". abLILty to "normnLine" n~yciv~ph~,:~[o1-, i(.nl rq:::~op..':~vit.y ~%d thu~ nllow for "~ore • "rf~c|,::it bnh',','i~,-.,l p,,rfor~n::ee and incrensed ~ubjectJ.ve wn I i - h~. ] n ,:. "~th r,-'-'..-~t, tn th.'re n.-~u,nntLqn';, ~.t Lr, su.=.P:e~ted thrz~, the. ?otl.~:"}n'- h'.',~othe~en bc exam~n,:d: I • Int-inrir :~"::c;t~)phy"lolocic,n-I fnctoro o.n~rnt~ in ~om~. ~:~,li'.'~du~l"" t.~ l~,',;,li~po~e them to the acnu~n~t~.on of a "',~..hqdt :, ,~,t•e~y or te,~:t.=. - pcychnl, hv~Lolo,-=.ical, a,l~inknt.-~',,.' to y,,:~.~;: ch~1,1ren (8-9 yr',', of are) .~n,1 they ~'.'o'~ ! ,'- ?oL1.,v'e,l un over a h-5 year pcr£o,~ ('or the p,~,',~..-., .;r ,,rl.;"~c;1,J.n~ the incidence of :'mokerr .~n,l no-~--"~n4 ..... :, c~ ,..';nm~.nJ.n:' the re1.;ttLon~h~p o(" th(,~o tent ~,nt!.c,-~.,, • L', l..h,;~.~ .... nokin.'" - non-:'mnk~n,; ~t,~t,J.~. It, wout,l ~,,. :::~nec't.,.,! i.h:,t .:mo"er'; mr'l non-:',,~k,:rr. -;-oul,l be (luLte • !~'l',,.Peltt v']l.', r'~'":~OCt to th,.,Lr ~nLttnl te=t re;;ul.t:. A'I,'i tLonnl "~I 1.}~:-,~nn (5.ye.~r.~, 10, ] 5, 20 . •. ) could b,: ~-,it~',t~.~ ,~.~ LIp..:~me -roup to (~et~.rmLne the ]on,:-term .~m~::er n'r+ , nn-'9-~',~r s~.ntu= of thi~ r.nme rroup cample. C~ BatCo document for PFSFC 1 March t999

. , . .. RL)YAL OTTAWA 1IOSrITAL ItC)PITAt ROYAL I)'OTFAWA • .° o ~e 1145 CARLING. OTTAWA. ONTARIO KIZ 7K4 TEL. 813/122-6521 Alth,);J,'h :',.~,~k|n-" nh~t~nence [~ carrel:fLed i.:ith t~mporar~l !l.~?/eho$,~ ;.",1 ,'.:/"~:~to-~.-., n= l,~ the dL.~co,~LLn'nation of" • "itW ~.rr~i;-"h~l~it", t,h-, phv~Lolo,'icnl alteration~ OCCtJr"irl'" ;lt 1.tl~, ti.'l~, oJ" .'ll)~til~ence ore not transitory ~hn.~r~n~ i1.L~."- tel nted to a "smokin,~-wlth,lr.:.';:aL" nhenomena whleh ret,arn to"nu:'mal" after an olnp::ed tLme period. ~t tn Cu,'F,,~L..:I h,.'r,J that the phy~Loto.=.Lcal alteratlono are refl.'.cti',e of ~ returr~ to ~i en,lurin~, p~.vchophysLolo~.Lcal =akeup which Lu charncterL~tic of =,,okern. "'ethod: .:~n".,r': .r,-,J:n tobacro-nb=tillertce clinics will be ,~,~l,'tt~r~..l !,.e.~...,., :,i,l ~'or I year after (at 1 month ~ntervals) :.'mm'-.Ln,." ce-:-:,~L~ ::'Lth re:::~rd~ to ;~ batter:! of tests In~l,,.'ir;- p"ych,}phyniolorlca~, p~:Ichol,),:Lcal a~i,l hehavio;..nl narnmoter.~. It v"),ild be expected that phym[o- ].o,oi.c~l ~h~:',:~. v'o.l],1 not ch,'m~e over time m~<! that n~o':er.-., r,.t.~t.ive to non-.-.,nnkez's ~voula continue to exhLbi.t vulrlqrnb~l.~t'., to -i,'en~ arid irlef£LcL.~nt perfol'mrmce evon nf~cr I ','"'~". :'~.~p~rt of tlx~.~e fLndin:,r, c,o,itd di.-.mL.-,s the rIP-r[ri,.ni.i,~,, ~lr ;,ohacco a.~ a "dopen,InliC¢'" 'lisor,ler as • i ;;'i. th:lr:r';'.,1 -';,;idr'ime i.'; cr,ici.al, to the de!'inition of • lrll- ~!~.llci,.l,',.i-.-, ~e £;= toba,:c'~ "-n.~:Ln~. alleviate:: stre::~ hy (a) red,i~';-n.~ the ].~.".~Cl; O.~ ~--.:,..:~vr. rti',~,Jlnt~on ~I~,'.' by (~) [ncrea.-.Li;r' i:~ r:):-lrl C i ,r ~. ,,....~ .¢, .... -. l hr. ,~n,i ntten t i anaL- f L l te-i.n:, c.~ na c t t:/, ~LL i'. ,|'lil." ,-',:r',,'~:,ble I;o hvnothe~Lze that {t wo0.1].,t hove aerial'it. ,:!i"~L"?L ,til Lty For p~ychintrLe patients who .~'-.hLbL¢ -.,~,.h .:~-,q--1,~r.~ irl the e'{tremn. '[~h~ receive:; ~.-,l['-ect ,,.,-..,,~rt from the ":;or thnt nn:/chJatr[c nnttont.~ ,.~:,:i[h[ ~ n ".'::-~:~,il" hi ~.hur connumpt.[c~ rate than the li-~r~;il ;~)~'~l','.[orl ~;v! they ,:xhibit marked d~.~tre~.~ when .-,u?~;~1[e.~. -~i'? 1"3":. "..l.ll,rl i .I, "'~Oi ~l,hy':inlo~i('nl, p:,.;Ich,)lo~:icnl n,id i~ehavioral ~."':L:" w|ll '., -,.imi,,i:-L,,r~.,l t.o vari~'l.~ rltnlc:ll e,~t,.,.rories ( i . . ~ :-rhi ~',li."lr .... ii c,'l ljil .: i • I,),~ ~qll,1. ,I,,p.,'e';ncd p,-il~ient.~) t,,f~ I,. i~4 ~" '*' i'~" ;'.ll,,l.~ll'r c1 i.lli.C;Ilj. Ryl'llltl'i,'n.': at',, egn,"t:ernl;ed "ol.lo-:'i;1 1, ", i 'l~vr. cl~ ni,.'.ti.ne'~C," ~rld wh~l;her they 0 r~ C~ Oo BatCo document for PFSFC 1 March 1999

ROYAL OTT&~VA IIOSrlIAL I IOPITAL ROYAL D'()IIAWA .. 1145 CAIILING. OTTAWA. ON rA/~llO KtZ /K4 TEL. 6131722-6521 °- o. ?he comt'i::~.'t ,-~.~.nrch pr.~1~)~nl.-, could bQ c.nrried out OVee n ~ yen.~ .-.n:m, ~h,., initi:~l lr;t ~ year~ wnu14 be foctl~ed on proposal. :~o. 1 , [.e., c~] l•*rtLn.~, n lar,,e .~nm!~Le oJ" chLldr~.n ~id acquirin,: nrofile.~ for fut~re reference Ln the 51;h y~.ar. The l;hL:'I nn¢l fo,.~rth yeara we,lid b,e focuned on 1;he 2rid anrl }rd p,-or.,~co~.~ (one year Eor each) nnd the 5~h year wo,~Id h? :ledic:tl.~.,l t.o fnllowin-,p the ~nmple of ch~.idren for 1:he ?i.nnl e,~ll..,etton of data. .vt" ~.here ~-.:~nrch nro~oco]= are accepted for 'nupport it L.-..~t~ctnn~.-,' r..h~t th"y ;':i11 n'~ inLtJ...nted follo",'in.= Pha~e Ill o.r -,v ~,'c~cnt r,,:-~n~ch pro~ec~. on "Tobacco 3mo;,in~ m~d :~t;ress ':=¢~,~ct[on" v:i r.h ".P.:'.C. "~'!:e r,.,':enrch buc!zet per ,~nnum should ~.ppr~..~nCe tlw r:-, .~,:r0. -ate ;"ith m~nor alteraLLons to CO,.a.rt.~|~-.~LQ f'Ot" ~:s¢:T.~,'l~e ] CLI.~':~.''. \1 l,ho~ "!t -.n-.h '~ Lb., ~. pr3L.~,.'~Is m..:, :'enrel tow:~rd.~ ,~.:nc:-al "h.',..-i~: -,:i,m:.;"i,'. eorr,,lnb~r'' of tobacco s'no;".in~~ |.~., .";hc~ a,'v '.h- ~.,~.:,, "lcinl or ~otivatla,~l .~ainc behind ~;hc'","l,*~l;.t.'~=,:'. ;. " "'." ,~r ~.l. -areLle .-.,.-.olin.it,° J..,>., ~,3r'kt C].n.:, ~." "Ln hu:,e,l l!s'.L :~('~'"1':.;",':'" of .",he~e pz'opo~at.- .'*or ."u.nporl; v:~L1 r,..~n~ i.t ,~ :n~-~, l~'cLd ~md-r':;t.nnrl~n= of nttr,~ctLon of ¢hn to~.~cco :',-'."::n," l~;O,it. ==..==~ 0 O0 0 0"- BatCo document for PFSFC 1 March 1999

• o . IDENTTFYZNG PSYCHOPHYSTOLOGICAL PREDICTORS OF TOBACCO USE IN CHILDREN: A F~VE-YEAR PROSPECTIVE LONGITUDINAL STUDY Research Proposal Dr. Verner J. Knott Royal Ottawa Hospital Submitted to Canadian Tobacco Manufacturers Council, Nov/1981. t.1-1• • | •, BatCo document for PFSFC 1 March 1999