DeBethizy, Joseph Donald, Ph.D.
(RJR toxicologist and director of R&D, c. 1994)He is a senior toxicologist at R.J. Reynolds. He has knowledge regarding the toxicity of nicotine effects of nicotine including its effects on the cardiovascular system. Specifically, the increase in heart rate, blood pressure, cardiac output, stroke volume, myocardial contractile velocity and force, coronary blood flow, myocardial oxygen consumption, arrhythamea induction, and electrocardiographic changes. Other effects of nicotine including genotoxic/carcinogenicity, reproductive hazards including teratogenicity and pregnancy/fertility, pulmonary toxicity including emphysema and Additionally, he has knowledge regarding the function of nicotine in the body. Finally, he has knowledge regarding both the pharmacological and physiological effects of nicotine.Director of Research and Development for R.J. Reynolds Tobacco Co. circa 1994. He spoke on ABC's Day One program on 2/28/94. deBethezy? said that people smoke because they are looking for pleasing sensory experience with mild pharmacology (J. Slade Statement 3/25/94) deBethezy? admitted that a water extraction of tobacco would have nicotine in it. He claimed that tobacco extracts are used as flavor materials (Day One 2/28/94). deBethezy? admitted that he thinks that this could be done (taking all of the nicotine out of cigarettes) (Day One 2/28/94. See Bethizy, J. Donald, TTLA Almanac - Names.