Tobacco Documents Online

Reports on experiments using pattern reversal evoked potentials (PREPs), evoked potentials to olfactory and trigeminal stimulants (EPs) and electrotrigeminograms (ETGs) to explore the effects of smoking on the central nervous system. Demonstrates that smoking produced a decrease in PREP P100 latencies over time. States that maximal central nervous system effects are achieved while smoking, but quickly dissipate. Explores effects of nicotine delivery on P100 latencies.

Consists of edited "draft" transcript from free-ranging discussions regarding how to achieve consistent nicotine deliveries via additives, filter designs, blends, etc. Identifies individual speakers and corporate researchers. Compares Reynolds and Philip Morris products and discusses various corporate methods and projects. Contains editing in marginalia.

Public statement by B&W addressing Barclay controversy and use of Actron filter. Claims that the Actron filter improves taste delivery through unique smoke swirl impacting a large number of taste sensors in the mouth simultaneously. Discusses deficiencies of FTC machine testing system, and argues against singling out Barclay cigarettes for exclusion from this test methodology given the many modes of compensation possible among brands for human smokers.

Reports micro-encapsulation menthol studies which establish a "sub-recognition" threshold of about 150 parts per million [ppm] using human subjects. Indicates the primary focus of these studies is to define the formulation of menthol or menthol analogues which would be useful as "smoke-smoothing" agents. Describes experimental design studying the micro-encapsulation of menthol in detail and presents these data in the form of charts and graphs.

Kools study demonstrates free nicotine and MRE increase with increasing smoke pH, while nicotine and nicotine/puff decrease. Smoke sensory analysis showed increased impact, irritation, tobacco taste, and menthol with increasing smoke pH. "Medium" sample was most acceptable, perceived as highest level of impact and irritation. Concludes that increased smoke pH may aid consumer acceptance.

Charts and notes detailing differences in smoke/ sensory character between major companies and emphasizing unique character of Marlboro. Among findings: PM brands rated natural/ weaker in sensory characteristics, while RJR rated natural/ stronger, and B&W rated stronger/ artificial. PM brands show reduced irritation vs. tar/puff. Marlboro pH profile higher than compared brands with spike in last puff, higher smoke ammonia, and greater nicotine transfer efficiency. Reverse engineering of Marlboro used to determine role of DAP and ammonia in dark recon, role of urea, and effect of PM band cast type recon (CPCL) on B&W blend. Concludes that both ammonia and DAP are necessary for best sensory effect; level of urea critical, and best if applied to low ammonia component; use of band cast type recon (with DAP) alters nicotine distibution, pH profile, and nicotine transfer efficiency (NTE).

Discusses effects of free nicotine on smoke impact. "Smoke impact is defined as "smoker's degree of awareness of the presence of tobacco smoke in the back of the throat." Describes model for smoke impact through receptors activated at back of throat. Claims the degree of smoke impact is determined by the amount of free nicotine in the smoke. Notes that free nicotine depends on smoke pH and total nicotine. While total nicotine represents the potential nicotine available to the smoker, it does not represent the free nicotine that is actually available "since the smoker is unable to employ strong bases in order to liberate all the nicotine, that is, at least not in his mouth." Concludes that it should be possible to "create an ultra-low tar cigarette that produces much more impact than its delivery would suggest."