Product Design
The Electrophysiological and Subjective Effects of Nicotine Aerosols: Comparison to Cigarettes
Abstract
Outlines a series of experiments, in support of Project Leap, to determine whether nicotine aerosols produce electrophysiological and subjective responses comparable to nicotine in cigarette smoke. Plans to investigate the effects of aerosol pH on electrophysiological and subjective responses. Suggests puff by puff comparison of nicotine aerosol to cigarettes with varying nicotine delivery levels.
Fields
- Author
- Gullotta, Frank Paul, Ph.D. (Tobacco chemist, Philip Morris, Cologne, Germany '94)Developed and used EEG techniques to study relationship between nicotine addiction and blend properties. Worked moved off-shore in 1986 to avoid discovery.
- Hypothesis
- Smoking psychology and behavior
- Neurobiology
- Keyword
- Electrophysiology
- Smoke Constituent
- Nicotine
- Operation/Project
- Project Leap
- Technology/Method
- PREP
- Subject
- aerosol (technology)
- nicotine technology
Document Images
7_`4_p'ppt fGIJlCST
The Electrophysiological and
Subjective Effects
of Nicotine Aerosols:
Comparison to Cigarettes
7_84_p.F,,t FGUICST
Objectives
In support of Project Leap:
Determine whether nicotine aerosols produce
efectrophysiodogcal and subjective responses
comparab[eto those produced by nicotine as
delivered in cigarette smoke.
Investigate the effects of aerosol pH on
e[ectrophysioiogicai and subjective responses.
Determine how the magnitude of the electro-
physiological and subjectiive responses obtained to
nicotine aerosols compare with cigarettes over a
range of nicotine deliveries.
7 I--4_p.ppt FGU/CST
Expe'.riments
(1) Puff x puff comparison of nicotine aerosol
(approximatefy 60 pglpuff, pH 6.0) with 0.41 mg
nicotine delivery cigarette.
(2) Puff x puff comparison of nicotine aerosols
approximately 60 pg/puff) at pHs of 6.0, 7.0,
and 8.0.
(3)
Comparison of 3 n,icotine aerosols (pH 6.0)
delivering approximafely 17, 60, and 120 pg/puff
with cigarettes delivering 0.12, 0.41, and
0.8 mg nicotine.
Dependent measures: PREPs and descriptive ballot
N= 20 subjects for each experiment
