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Item 1 ACCESSION NO. . CCNFERENCE AITTHOR ORGANIZATICN TITLE ABSTRACP : 398 : 2316 . RASKINO LNPi : IMPERIAL TOBA0C0 C0. /EIQCLAItID : AN APPRUACi TO THE ORGANOLEPTIC LWr=CN OF ADDITIVES IN TOBACxO PRC)DUCTS : AN APPROACH TO THE ORGANOIEPTIC EVAI+UATICN OF ADDITIVES IN TOBACCO PR(JDUC.TS . FIVE PRINARY "TOBAG7C0 SENSFS" ARa4k, TASTE, SATISFAGTION, PHYSICAL FEEL AND SIGHT, ARE PUT FORWARD AS REPRESENTING THE NUN ©RGAr10TEPTICS INVOLVED DURING EVAU=CN OF TOBACCO PRODUCTS BY A PANEL. WITHIN THIS SEMtY FRAMRK IT IS POSSIBLE TO EXPLORE A WIDE RANCE OF ADDITIVES WITH A VIEW TO USING TfEM EITHER SINGLY OR AS BUILDING B?ACKS ACJCXRDIlNG TO THE DESIRABLE COIVTRIBUTIONS THEY MPiKE TO TCBACC0 PR(JDUCTS, "THRESHDIa VALUES" ARE FIRST DETERMINED BY TRIANGLE TESTS IN ORDER TO ENSURE THAT THE ADDITVE-C70NPAINING TOBACCO IS SIGNIFICANTLY DIMERENT FROM THE CONIRCL. FINAL ASSESSbENP IS Np1DE USING SUBJECTIVE NETHODS OF SENSCF4Y EVAIMTICN FOCUSSED ON SELECTED SECC7NIDARY FACTORS DERIVED FROM CX+]E OR M)RE OF THE PRIMARY TOBACCO SENSES. BASED ON THE EVIDENCE TO DATE, IT IS S[GGESTED THAT THE FIVE TOBAC;CQ SENSES RESPOAID AS A SINGLE UNITARY EXPERIINCE DURING PRODUCT EVAII%TICN AND THE INTER-PLAY OF THE "VARIABLES" WITHIN THE SEW= FRAMWC)Eti{ IS WHAT MJTIVATES A PANEL TOWARDS ('3VERP,LL PREE'I;+ RMNCE . A GLOSSARY OF 18 TERMS USED IN. THIS STUDY IS GIVEN AND RESULTS FRCNI AN ACTCLAL LA80RATORY PANEL TEST ARE DISCUSSED. : 1969 i I

Iten 2 p,=SICN NO.. CGNFEEiEC7CE AT,TI'HOR. ~iGANIZATICN TITLE ABSTRACT : 533 : 2627 : JOHLQSON BtR : BR(7WN & WILLIAMSUN : CQUPARISON OF D- AND L-MENTHOL AS CIC,ARETTE BZAVCRANTS : COMPARISOJ OF D- AND L-MMM AS CIGARET].'E HZAVCRANTS . THE ORGANOLEPTIC CONTRIBiPDIONS OF NmVTBOL TO CIGARETTE SM3KE INQ,UDE FZAVCR, COOLING, AND SMJOTHnr. EFE~'~C'I'S. THE PREDOMINANP SENSATION OF NATURAL NFNTHOL IN SNDKE IS COOLING, WHICR LARGELY NASKS THE FIAVCR.. ACCORDINGLY, IT WAS OF INTEREST TO PREPARE TEE ENANTIOHEt, D-NENTHOL, FOR 4C-ANOLEPTIC CCNPARISOTiS.. A SAMPLE OF CQMMEEiCIAL DL-bEV'itfiOL WAS TREATED WITFKX)T PRIOR PURIFICATION WITH L- CHIIARIDE TO GIVE THE DL-NEN'I'HYIrL-ESTER, FRACTICNAL CRYSTALLIZATION THEN GAVE D-NENTHStIrIr NTWITH NETT.,TING POINT P,M ROTATIO+i VALUES CLOSE TO THOSE REPORTED BY REID AND G:tUBB (J. SOC. CHEM. IND., 51, 329T (1932). AIMJST PURE D-MENTHOL WAS THEN OBTAINED BY HYDROLYSIS AND SUBSEQUENT DISTILLATION. ALL NECt4aVTHOL WAS FtF.M3VID IN THE RE.SOLUTIOrT OPERATIONS, BUT THE PRODUCT D-NRSfl'HOL WAS ACCCMPLISHm VIA THE CYANOACETATE ESTER. SANPLES OF L-NEIVTHOL AND DL-NIINflZiOL WERE SIMILLARLY PURIFIED TflF0UQi THEIR CYAIJOACETATE ESTER. ALL THREE PURIFIED SAbPLES WERE PURE BY GLC. A COMPARISON OF THE D- AND IrKZflNOL SANBLES SHC7WID THE D-blalTiOL TO BE OPTICALLY PURE: MELTING POINT- 1-MENTHOL (42-43 DECREES), D-NR~]THOL (42-43 DEG2EES) ; LIT. MELTING POINT- 1-NFTIZIIOL (42'-43 DFGREES), D-NID.VTHOL (42-43 DEG2EES) ; ROTATION [ALPHA]D- 1-MENTHOL (-49.9 DEGREES), D-MENTHOL (+49.7 DEGREES) ; LIT., ROTATIOTI' [ALPHA] D- 1-MENTHOL (-49.0 DEGFEES),, D-MEJTHOL (+50.1 DEGREES). ORGANOLEPTIC EViUATICNS VERE ON PREE'ORMED CIGARETTES MADE FRONi A MENTHOL CIGARETTE BLEND, BUT COIVTAINING IQO MENTHOL. BOTH SYRIlQCE INJECPION' AND SLOW VAPOR DEPOSITION WERE USED TO bENT'HOLATE THESE CIC,ARETTES WITH THE D- AND L-N&MHOL SAWLES, AND ALSO THE DL-MMiOL. THE EFFEC,`T' OF D-NENTHOL ON' CIGARETTE SNrJKE, AS CCNPAF2ED TO THE L ISOMEEt, IS REDUC'ED COOLING AND SLIQ3'lI,Y ALTERED FLAVCR. THE REDUCED COOLING EFFEC'T OF D-bEN'IBOL IS PARTICULARLY APPARENT AT LOWER CIGARETTE LOADING LEVEd,S. SMDKE FiAVCXt OF THE D-NEVTHOL CIGABETTE HAS A DEFINITE CAWHOR-LIEE NOTE WHICH IS MUCH LESS DISCEFOTIBIE IN THE L-NENTHOL CICARETTE. CIGARETTES WITH PURE DL-MENTHOL ON' CIGARETTES GAVE GFEPsTLY DIFFERENT FIAVtYt MDUE TO APPRECIABLE Ab1JUNPS OF MENTHOL ISOMERS. ORGANOLEPTIC EVAIaMCNS OF THE PURE MENTHOLS PAR.AT,TFTF:D THE EFFECTS ON SNIJKE TASTE. : 1972 m

Item 3 ACCESSION NO. COAFERENCE AUTHOR ORGANIZATION TITLE ABSTRACT : 534 : 2628 , AAr.raH F $ WEYBF0q JA $ MXF0E R.I : NORTH CAROLINA STATE UNIVERSITY (1966+ ) : SENS2Y TESTING OF TOBACCO SMDKE--I. IS TASTE A NEF,SURA8IE QUANTITY? :SOMMtY TESTING OF TOBACCO SM(ZE--I. IS TASTE A NE7ASURABI£ QUANTITY? ."TASTE" OF TOBACCO SMJKE IS A GRERIC TERM ENCOWASSING THE CXIK>OSITE SEIQSATIONS OF ODOFt, STRENGTH (NILIDNESS) AS WELL AS TASTE PER SE. THE OVERALL INPRESSICfi1 TO THESE SENSATIONS IS ALSO AFFECTED BY THE BUFt1JING QUALITIES (RATE OF BURN, TEMPEEtATURE, AND CQIO2 AND COHEE2IIJCE OF ' THE ASH. ) THE EFFECTS OF Tfa+7C) HEAT TREATNmVTS, TWC) PRESSIIu TECHNIQUES AND THREE ADDITIVES' FORMJIAE, SINGLY AND IRCOMBIlVATION, ON THE QUALITY OF ASMZING TOBACCO BIaID WAS INVESTIGATED IN A 2 X 2 X 3 FAC'PORIAL-EXPERINIINP DFSIGN USING EIGiT' TRAINED PANELISTS FOR SKM EVAILm=CN. THE VALIDITY OF THE FINDINGS IS LARCELY DE2ENIDENT ON THE Nj2ITHODOLOG'Y WE HAVE IldTRODUCID, TO SEQIRE THE FOLLOWING: (1) THE IMPORTANCE OF Dg'INING AND SEMIQi,]ANTITATIVEI,Y MEASURING THE PIINEI,IST' SSEW= r=M= TO THE EET'EC'P (S) IMPOSED BY THE ABOVE TREATVlENTS UPON THE SMJICIlJG QUALITIES. (2) EXTREME CARE IS TAFmi' IN QJIDING THE PANELISTS TO DETECT THE CHARACTERISTIC EFFECT UNDER STUDY P,M DETERMINE ITS AMpLITUDE OR. INTENSITY USING A QUANTITATIVE SCALE THAT CAN BE DEALT WITH NATMWICALLY. THIS WAS OBTAINED BY ENPIAYING A SERIES OF PAIRED CCWARISCN TESTS IN A"DIEFERENTIAL" FASHION WHICH ALIrOWS DETECTING THE ' "TRUE" EFFEf.T WHICH ALIAM DETECTING THE „TRtJE° EFFECT AND DETERMIINING ITS "NATURE". (3) THE RESULTS ARE STATISTICALLY TESTED ON THE BASIS THAT EACH OF THE VARIABLES (SMJKIhiG QUALITIES) SUBNJITTED FOR EVAIL7i'PICN IS INDEPENDENT NORMAI1,Y DISTRUBUTED, HENCE, THEVALIDITY OF THE NORMo,L DISTRIBUTION NIJDEL FOR THE VALUES ARE' OBTAINED WHILE MEETING THE ASSUNpTICNS UNDERLYING THE ANALYSIS OF VARIANCE PRODEDURE, WE CAN DEPEND ON THE PROPERTIES OF ANALYSIS OF VARIANCE IN1 DETECTIlJG' THE EXISTIENCE OF TRUE DIFFERENCES ANONG MEANS OF TpEATMENTS' EFFECTS A,l4D SUBDIVIDING THE SUM OF SQUARES OF THE' RESULTS OF DE VIATIONS, HENCE, DECLEARING THE VALIDITY OF THE RESULTS (TEST OF SIFNIFICANCE). THE STATISTICAL ANALYSIS OF THE RESULTS OBTAINED ALLOWS US TO STATE: TASTE : THE EFFECT OF ONEHEAT TREA'INIENT IN IMpRCNIING THE TASTE OF SK)KE WAS HIGHLY SIC3NIFICANT, AS CcwA2ED WITH THE OTHER ONE, WHEREAS THE PRESSING TECHNIQUES DID NOT SHOW A SI{3NIFICANT EFECT. ONE OF THE ADDITIVES' FORMULAE SHOWED AN AINnST SICIVIFICP,IVT INPROVIIMENT IN TASTE AS COIvPARED WITH THE OTHER TIn1O FORMJILAE. THE SIQJIFICANC:E OF THE INTERACTION BETIn1EEN -TCP,C3-

PRESSING AND ADDITIVES INDICATES THAT THE IblPROIIIMENT IN SM?KE TASTE IS MJCH MJRE PROWXJN® Wf EIV A CERTAIN FQRMJLA IS APPLIED ALONG WITH ONE PARTICULAR PRESSING TECHNIQUE RATHER THAN ANOTHER. ODOR: AGAIN HEAT TREATWL+Tr SICNIFICANTLY INPR(3VED THE SMWE ODOR WHEREAS BOTH PRESSING AND ADDITIVES HAVE NOT EFFECT. STRIIJG'TH (MILDNESS )~ : HEAT T.EtEATMENT BROUCHT ABOUT SICNIFIC.ANI'LY MILDER SNDM, ALSO, ONE OF THE ADDITIVES FORMJtAE IMPARTED A SIGNIFICANT DEGEE OF MILDNESS TO THE SMURE. PRESSING TECHNIQUES HAD NO EFFECT. Bik01ING QUALITIES: NONE OF THE THREE TREATD+ENTS, THAT IS, HEAT, PRESSING AND ADDITIVES, HAD A SIGNIFICANr EFFECT IN BURNING QUALITIES. TOTAL EFFECT: THIS WAS OBTAINED BY SIJNMING UP THE SCORES PROPERLY WEICHED FOR TASTE, ODOR, STRIIQGTH AND BURNIldG QUALITIES. THE FINDINGS APPEARED TO BE IN LINE WITH THE ABCn7E. HEAT' TRFA7.WVT IMPARTID A HIGHLY SIGNIFICANT INPRaVMM UPON THE CJVERALL EFFECT OF SNDEM WHEREAS PRESSING TECHNIQUES HAD NO EFPFCT. THE EEt ECr OF ADDITIVES AS Sn1ML AS PRESSING X ADDITIVES INERACTION WERE SIQJIFICANT. THIS NEH'PODOIAGY ILi,tJSTRAZE.S THE POSSIBILITY OF' APPLYING THE KNCW STATISTICAL MTHODS TO THE PPaUEM OF SEN90W EVAI=CN OF TOBACCO SWEE. IT ALSO: EMPHASIZES THE PRUDIINK'E WITH UffiICH INVESTIGATORS MJST' OCNIDt7CT THE SbDKIlQG PROCEDURE ADID INTERPRET' THE RESULTS TO ARRIVE AT VALID FINIDINGS. YEAR : 1972

Itesn 4 P,CCESSION NO. CONFERENCE AiJTHOR. ORGANIZATION TITLE ABSTRACT : 555 : 2649 : RICE JC $ TERRILL TR $ CURRIlJ RE $ GOLDEN R $ CLARK F : NKRIH CAROLIlM STATE UNIVERSITY (1966+ ) : QiUALITY DETERMINATICXQ IN FIUE-C[7RED TOBACCO AS EVALUATED BY THE MINDM STANDARDS PROG2AM : QUALITY DETERMINATION IN FLUE-CURED TOBACCO AS EVALUATED BY THE MINIM&i STANDARDS PROCRAM . THIS PAPER DESCRIBES THE MIIVIMA+'I STANDARDS PROGPM IN OPERP,TION IN THE FIVE FLUEr(I)RED TOBACCO PRflDi7CING STATES. THIS REGIONAL PROGRAM, ATTEMPTS TO EVAI,t]ATE ANY NEW VARIETY ON "QUALITY" AS OBSERVID FROM PGRCJQ+ff C, CEEMIICAL, PHYSICAL AND SNCEE CIjARACTEftISTICS. POTENTIAL VARIETIES ARE COMPAR'ED WITH THE MEAN OF TWO STANDARDS VARIETIES- NC 2326 AND NC 95. A STANDARDS COMMITTEE CCiMPOSED OF TOBACCO BRE®ERS ANID TOBACCO INDUSTRY RESEARCH WORRi:RS DISCUSS AND ESTABLISH CERTAIN LINIITS FOR FIVE aiElMCIAL CFiARACTERISTICS. ANY NEW ENTRY IN THE REGIONAL TESTING PROGRAM MJST MEET THESE LIMITS BEEORE IT CAN BE CONSIDERED FOR RELEASE. THE LIMITS MAY BE CMNGFD BY THE COMMITTEE AS KUKET DENANID NAY DICTATE. THE CIJRRIIaT NIINIl4jm STANDARDS FOR CEiEMIICAL CHARACTERISTICS INCLUDE LIMITS ABOVE AND BEIAV+T THE MEAN OF THE SPECIFIC aiaIICAL C3AR~ OF STANDARDS FOR aiEmIICAL CHARACTEEISTICS INCLUDE LIMITS ABOVE AND BELOW THE MEAN OF' THE SPECIFIC CMIICAL, CfiARACTER OF STANDARD VARIETIES NC 2326 AND NC95. THEY ARE AS FOILOWS: TOTAL NITROGEN (+/-) 10%, AIPHA AMINO NITfiUGE1 (+f-) 15%, INSOLUBLE NITROGEN (+/-) 10%, NICOTINE (+) 15% TO (-) 20%, SOLUBLE SUGARS (+/-) 15%, "NORNICOTINE" THIS SFCCNDARY AMIr1E AIIfAIAID AS DETERNMM BY CUAIDIFF AND: Nq,RKUIW CAN NOT BE MJRE THAN 8% OF TOTAL, ALKALOIDS FOR SPECIFIC ENTRY. PHYSICAL EVAIxIIMCN IS OBTAINED ON EACH NE+W VARIETY FROM TOBACCO PRODUCED AT TWELVE LOCATIONS. FARNER-COOPERATORS GiOTnT ONE-FOURTH ACRE OF EACH ENTRY, HANDLE IT ACCORDING TO NORI-AL FARM PPtATICES AND PIAC'E IT ON WAREHOUSE FLOOR AT SPECIAL DISPLAYS. TOBACCO INDUSTRY RESEARCH AND LEAF PERSONNEL EVALUATE, UNDER CODE, EACH SHEET OF TOBACCO FOR COLOR, TEXTURE AND BODY. EACH POTENTIAL VARIETY IS SUBJECTED TO SNDKE EVAIMCN.. STANDARD NON-FILTERED CIGARETTES ARE Np1DE FFipM EACH ENTRY WITHOUT BLEND OR ADDITIVES. QUALIFIED SNDKE PANELS DETERMINE ANY OFF-FLAVM OR OBJECTIONABLE TASTE DUE TO GHIETTC CONPOSITION. A SUNNgiRY BY YEARS SHOWS THE NUMER OF ENTRIES ELIMINATED DUE TO SA9JKING TESTS. RESULTS FROM SEVEN YEARS OF TESTING SHOW THE TOTAL NUMBER OF ENTRIES FOR EACH YEAR AND A SUi4TPM OF THE NUMBER OF ENTRIES FAILING TO MEET THE MINIMJM, STANDARDS. THESE TESTS WFRE CONDtJCTED IN FIVE STATES. TWO INA.TOR' SULCONMITTEES ARE CHARGED WITH THE RESPONS IBILITY OF (1) I(EEpING STANDARDS UP-TO-DATE AND

(2) USING ALL AVWLABLE DATA TO EVALLMTE NEW VARIETIES. FULL REPRESENTATION OF TOBA(CO INDUSTRY ANI'i? RESEARCH WC)RI<ERS IS OBTAINED ON A ROTATIIVG SYSTEM CN THESE C''ONMITTEES. THIS TYPE OF COOPERATION HEIPS IN PtECOIMMING FOR RELEASE ONLY THOSE NEW VARIETIES THAT WILL PERFORM FOR THE FARNERS AND BE ACCEPTABLE TO THE TOBA7C70 IPIDUSTRY. YEAR : 1972

Item 5 A=SION NO. A:o:.I a a1:4 nI.'A AU'IHOR. ORGANIZATION TITIE ABSTRACT : 652 : 2845 : HALTER HM $ ITO TI : AMERICAN NACHINE & FOUNDRY : SF3N.9atY ANALYSIS OF CIGARS :SENSOtY ANALYSIS OF CIGARS A DESCRIPTIVE ANALYSIS METHOD DEVELOED BY THE STANFORD RESEARCH INSTITUTE HAS BEELQSUqCESSFULLY APPLIED TO THE SENSORY ANALYSIS OF CIGARS. THE NETHOD COMBINE.S SCYME OF THE BEST FEATURES OF THE OTHER PROFILE PROCEDURES WITH SOUND PSYCHOLOGICAL PRINCIPLES AND A UNIQUE C+OMPUTER. ANALYSIS PROGRAM TO PRpVIDE AN OB&JECTIVE SEr19Qt]f ANALYTICAL TOOL. PANEL EVAILM'TiCN INCLUDES THE ENTIRE SENSORY EXPERTF4CE INVOLVED IN SM)KIlQG CIGARS, INCUDIIQG TfiE APPEARANCE, blOPl'FI FEEL, COLD AEa4k, COLD TASTE, CCt"IDUSTICON TASTE AND P,RCMA AND AETERTASTF. THERE IS CROUP DETERbIlNATION OF QUALITATIVE S'EN9CRY ATTRILTPES AND AGREEMENT ON TERMINOLOG'Y, BUT QMVTITATIVE RATING OF SANPIES IS CARRIED OU'r ON AN INDIVIDUAL AND INIDEPENIDENT BASIS. INPR(7VEID PROCEDURES ARE INVOLVED IN PANELIST SEIECTICN, NDN: NUMERICAL RATIO SCALING TECHNIQUES ANID USE OF AN IIaTII2AC.'TION[ TERM WHICH OVEP40CNFS SOME OF THE DIFFICULTIES INVOLVED IN STRAIGHT N[MERICAL AVEEWING. CCMPUTER ANALYSIS OF THE DATA YIELDS IlSIFORMNTION DTi PANELIST PERFORMNCE, THE SIQJIFICFINCE OF DIFFERENCES BETWEEN SANPLES, AND CORRELATIONS BEZWEE1 THE 3ENSICItY ATTRIBU'iES. THE PAPER CON(I[IDES WITH CASE HISTORIES ILLUSTRATING HC/W THIS PANEL NETfIOD HAS BEFN' SUCCESSEVLLY ENJPLOYED IN DEVELC+ENT PROGRAM AIMED AT NATCHING OR NDDIFYING THE SENSORY PR(JE'ILES OF TARG'ET CIGARS. YEAR : 1974

Item 6 P,CCESSIfN N0. CONFERIINCE AiTIliOR ORGANIZATION TITLE PUBLISHED ABSTRACP YEAR : 653 : 2846 : P,BDAIZAH F $ NIZCE R,J $ WEYBREW JA : NORTH CAROLINA STATE UNIVERSITY (1966+ ) : SEWORY TESTING OF 'CIGARETTE SNDKE. III. PANEL CALIBRATION : DISSERTATION : PANEL CALIBRATIO WAS UNIDERTAXEN BY NEASiJRIlNG THE PANEI,IST' S RE'SPcTSE TO CwmS IN SMm ET,AVCR DUE TO ADDED AMOtJNTS OF SUGAR OR NICOTINE NALATE, EACH AT FOUR DIPFEEtENT CONKENTRATIOrTS. 7WIIVTY-ONE PANELISTS CCMPLE'1ED THE SUGAR SERIES (4 CCMPARISONS EACH IN 5 TBtIAlKllES). THE PP,NEL' S EE TO DECFiEASING AMXlNTS OF ADDED SUGAR OBEYS THE WEQEE2. FECHNEt LAW OF PSYCHOPHYSICS, THAT'IS, IT CAN BE EXPLAINED ADEQUATELY BY A LINEAR REGRESSIOr1 ON 1N (S[JGAPt). A METHOD G+iAS DEt7ELOPED TO DETERMIINE THE PANEL' S JUST-NOTICFAB.LE-DIFFERIIJCE IN SM3M ' F'IAVCR DETECTABLE AT THE 5% LEVEL (JND (.05)) VHICEI WAS FOUND TO BE 11 NG/G OF SUGAR ADDED ONTO TOBACCO THAT'ALREADY CONTAINED 15.8% SUGAR. BY ENPIAYING 15 PANELISTS, THE RELATIONSHIP BETWEEIV THE PANEL' SF=pCt= AND ADDED AN2OJNTS 0 NICOTINE MiLATE ALSO OBEYS THE WEBER-FFdapjER LAW. THE PANEL JAID (.05) FOR NICOTINE K%LATE WAS 6.8 M (OR 3.65 NG NIOOTINE) PER GRAM OF TOBACCO HAVING 2.14$ NATIVE NICOTINE. H:ENCE THE NAGNITUDE OF THE DIFFERENCE THAT THIS TRAINED PANEL CAN DETECT IS 7$ FOR SUGAR AND 17% FOR NICOTINE RELATIVE TO TIIE NATURAL CONCENTRATICNS. IN ABSOLUTE UNITS, HOWEVEEt, THE PANEL WAS MDRE SENSITIVE TO NICOTINE, WITH PROPER TRAINING THE N0MBER. OF ' PERFORMING PANELISTS CAN BE REDUCED. IN THE SUGAR SERIES, A PANEL OF 15 TRAINED PANELISTS PERFORN~D AS W,EL,L STATISTIC'.ALLY AS DID A PANEL OF 21 (THE SAME 15 PLUS 6 OTHEEtS) . THE CONSISTENCY AND HCMXENEITY AM3M THE 21 PANELISTS WERE AS SIGNIFICANT AS THOSE AMONlG THE 15, AND TRAINING DID HELP IN INPROVING THE PANEL PEEtFORNANCE. : 1974

Iten 7 Af„'CCESSION NO. CONFERENCE ALTPHOt ORGANIZATION TITLE PUBLISHED ABSTRACT : 654 : 2847 : ABDALLAfl F $ WEYBREW JA $ M3NRUE RJ : NORTH'CAR(JLINA STATE UNIVERSITY (1966+ ) : 3ENStY TESTING OF CIGAR= SMJKE. IV. PANEL USE : DISSERTATION :SENSCRY TESTING OF CIGARETTE SNDKE. IV. PANEL USE THE 15-NEMM PANEL WAS USED TO GIVE SOME IlNFOFM%TION P.BOUT TH QUALITATIVE DIF EERENCE IN SMOKE HZAVM OF EXPERIlMEVTAL CIGARETTES TO WHICH EQUIVALENT SUPRA-THRESHOLD ANDUNTS OF FREE OR BOUND NICOTINE (NICOTINE NALATE) HAD BEEN ADDED. THE PANEL FMMM IN FOUR TRIANGLES IlMICATED A SIGNIFICANT DIFFEEtIINCI: IN SM)KE FLAVKR ATTRIBUTED TO THE TGVU FO£4MS OF NICOTINE. EVEN WITH TWO TRIANGLES THE PANEL WAS ABLE TO DETECT THE DIFFERIISTCE SIGDTIFICANTLY. SMOKEFRCM THE ADDED FREE NICOTINE CIGARETTES BRWC,HT ABOUT UNDESIRABLE SENSOMt PRCPERTIES UPON THE PABELISTS. THIS IS IN P,GPEEEZVT WITH FAP7.M STUDIES SUGGESTING THE USE OF THE RATIO OF FREE TO BOUND NICOTINE IN THE IEAF AS AN INII)EX OF THE TASTE-QUALITY OF THE SMJKE; THE CFEATER THE QUANTITY OF FREE NICOTINE THE L(.)WEFZ THE TASTE-QUALITY. WHEN PANELISTS WERE PERMITTED TO TAKE TBE TEST CIGARETTE.S AD LIBITUM (INSTEAD OF IN BOOTH), THE DIFFERENCE IN SMOKE MVM WAS NC)T DETECTED. THE PANEL DISCRIMINATING ABILITY WAS SIGNIFICANTLY SUPERIOR IN THE IN-BOOm THAN TAKE-OUT. HENCE, UNDER CONTROLLED CONDITIONS THE PANEL WAS ABLE TO DETECT DIFFERENCES IN SM)KE FIAVR WHICH WERE NOT DETE(.'TED IN THE PRESA4CE OF EXTRWOtJS NCx1-STINiJWS (LANQJOWN) VARIABLES IN THE TAKE-OUT SITUATION. THIS PROVES THAT THE PANEL' S HIGH PERFORMANCE WAS NOT ONLY DUE TO THE PANELISTS TMdSELVES (TRAINIlJG) OR TO THE TYPE AND INTENSITY OF THE DIF FERENCE TO BE DETECTED, BUT ALSO TO THE THREE-FOID CRITERION OF SENSCRY TESTING: TEST MATERIALS, TEST CONDITIONS AND TEST PROCEDURES. : 1974 n -TCRC9-

Item 8. ACCESSION NO. CONFEREIJCE AUTHOR CPC-ANIZATICJN TITLE PUBLISHED ABSTRACT YEAR : 703 : 2939 : NEWELL MP $ FECQWN RA $ MJATFS RF $ GREIN~ CR $ BEST FW $ SCQiUMACHER JN : REYNOLDS (R.J. ) TOBACCO : THE C(MPOSITION OF THE ETHER-SOLUBIE PORTION OF THE PARTICfJIATE PHASE OF CIGARETTE &4M : TOBAOCO SCIENCE. 21: 6-11; 1978. : THE CCMPOSITIfXJ OF THE ETHER-SOLUBIE PORTION OF THE PARTICULATE PHASE OF CIGARETTE SNX)KE . S4MCCNIDENSATES FROM 85 NM N(wILTERID CIGARETTES SNnIm UNDER STP,NOARD CONDITIONS WERE PARTITIONED BEiWEQI ETHER AM M1TER. THE ETHM-SOLUBIE K%TERIAL, 60% OF THE TOTAL, WAS C~ff0WOGRAPHED ON SILICIC ACID WITH INCREASINCLY POLAR SOLVENTS TO GIVE SEVEN FRACTIONS. FURTHEJR SEPARATION OF THE FRACTIONS BY LIQUII}-LIQUID PARTITIONS, COLLM aqCMiTOCRAPHS.', AND SENII-PREPARATIVE GLC LED TO THE ISOLATION AND IDENTIFICATION OF 648 St-M Ca4KMVTS. IDENTIFICATION OF INDIVIDUAL ISOLATES WAS P,UCCMPLISHED BY COMPARISON OF THEIR IR, NMt, AND MS, AND GLC RETENTION TIIE.S WITH THOSE OF AUTH=C S*PLE.S.OF THE 648 ISOLATES IDENTIFIED IN THE ETHER-SOLUBLE FRACTIONS, 224 HAVE NOT BEFN'PREVIOUSLY REPORTED AS CONSTITUENTS OF TOBA(JCO SNIOKE. THE NEW ISOLATES INCLUDE 20 ACIDS, 18 LACI'ONES, 8 NITRILES, 67 KETCNES AND ALDEH3Q7ES, 4 ALCOHOLS, 20 PBEN0LS, 31 NITROGEN HETEROC,'YCIFS, AND 46 HYDRCX'1ARBONS . CLASSES OF IXU4'OUDIDS FOUND FOR THE FIRST TIME IN TOBACm SNIOKE ARE REPRESENIED BY 2-F'mMMTEIlmIIDE, N, 3-DINETfiYLSLK;CININIIDE, 2-ISQPImPYL.SUUCINIlmIDE, PHTHAI;INIIDE, 3, 4-DIMETHYLPHTHALIMIDE, 3-METHYTPHTHALIlmDE' AND 4-NE'IfiYLFHTHAL=E, 2, 4-D , 2- LE„ AND N-METHYLDIILIAZOLE, EVAIMiTICN OF THEIR SZAVatING CIwACTEEtISTICS HAS ESTABLISHED THE IMPORTANCE OF MANY OF THESE ISOLATES TO THE OVERALL FIAVCEt OF CIGARETTE SMJKE. : 1975