Product Design
Ultrasonic Generation of An Aqueous Nicotine Aerosol for Subjective Testing
Abstract
Proposes changes to nicotine aerosol pH may affect subjective responses of impact and physiology. Outlines research plans to generate aerosol nicotine at controlled pH, describes the aerosol generator, includes schematics and states the aerosol composition is the same as aqueous. Indicates the nicotine concentration and pH can be adjusted, lists materials and methods and compares the physical characteristics of ultrasonic aerosol to cigarette smoke. Concludes an aerosol generation system for testing aqueous nicotine has been developed, the test protocol is refined and other substances may be tested using this protocol.
Fields
- Author
- Lipowicz, P.J.
- Hypothesis
- Free Nicotine
- Toxicity and consumer intakeDevelopment of scientifically valid procedures for measuring biological activity and neurological effects of nicotine and smoke constituents.
- Nicotine transport, transfer, and uptakeDesign changes which alter nicotine delivery or effect how the product causes and maintains dependence, including transfer of nicotine from tobacco to smoke, and uptake into the body.
- Measuring human smoking behaviorMeasuring the effects of changes in human smoking behavior on intake of nicotine and smoke constituents.
- Keyword
- Acidity (Low pH)
- Aerosol
- Bound nicotine (Protonated or ionized nicotine)
- Delivery modification
- Depth of inhalation
- Dose-response
- Free nicotine (Unprotonated or unionized nicotine)
- Human testing
- Impact (Throat grab)
- Mouth feel (Mouthfull)
- Nicotine delivery (Smoke nicotine or nicotine yield)
- Nicotine manipulation
- Per puff deliveryPer puff tar, per puff nicotine, and per puff CO
- Puff volume (Puff amount)
- Sensory response
- Smoke Constituent
- Nicotine
- Design Component
- Nicotine content (Tobacco nicotine content)Total nicotine in the unburnt tobacco rod
- Nicotine transfer efficiency (NTE)
- Named Organization
- Devilbiss
- Technology/Method
- Aqueous nicotine aerosol
- Subject
- Pressure Drop (Design)
- aerosol (technology)
- Experimental Technology (Technology)
- nicotine technology
- Particle Size (Technology)
- pH Manipulation (Technology)
- Puff Parameters (Measures)
- Effects—Smoking Behavior (Effects)
- Test/Inhalation (Testing)
Document Images
ULTRASONIC GENE ZATION OF AN AQUEOUS
NICOTINE AEROSOL FOR SUBJECTIVE TESTING
Peter J. Lipowicz
2 April 1991
HYPOTHESIS:
SUBJECTIVE RESPONSE TO NICOTINE AEROSOL CAN
BE ALTERED BY CHANGING AEROSOL PH
Impact
Physiological response
Protonated nicotine vs. basic nicotine
RESEARCH PLAN
Generate nicotine aerosol at controlled~ pH
Measure subjective response with panelists
Determine validity of hypothesis
Determine applicability of hypothesis
CHARACTERISTICS OF THE IDEAL
AEROSOL GENERATOR
Subjectively neutral matrix
Controllable and sufficient nicotine concentration
Controllable aerosol pH
Steady and reproducible output
Amenable to panelist testing
THE ULTRASONIC AEROSOL GENERATOR
Generates aqueous solution
Aerosol composition is same as solution composition
Nicotine concentration of solution can be varied
pH of solution can be adjusted with addition of acid
Can generate high concentrations,
Compact commercial units available
G.n4rator
R.stfrotr (E):
G.ys.r(0)
2020j26841
ISSUES IN THE DEVELOPMENT OF THE TEST PROTOCOL
Nicotine level -- 20'to 30 ug per puff
Acid to adjust pH -- phosphoric acid
Measurement of aerosol pH -- pH paper
Isotonicity of solution -- not controlled
Sterility of solution -- filter sterilized
Sterility of generator -- autoclaved'~
Nicotine concentration in aerosol -- spectrophotometry
Venting excess aerosol -- installed hood in Frank Gullotta's
laboratory
Sampling prodecure
Reproducibility of aerosol production
Physical nature of aerosol
REQUIREMENTS OF SAMPLING PROCEDURE
Simplicity
Delivers controlled volume of aerosol
Similarity to cigarette
-- inhalation by puffs
-- puff volume
-- pressure drop
-- size of mouth end
STABILITY AND REPRODUCIBILITY
OF AEROSOL OUTPUT
Required so that nicotine level can be controlled
Medium rate ( 1 g/min ) is not reproducible
-- varies for different aqueous solutions
High rate(4.5 g/min ) isbetter-- less affected by solution composition
