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PH I L I P MORIR I S U1. S. A. I N!TER-OFF I CE CO1RR'ESPONDENC'E R'J CHMIOiNlO, Y 1 RGI N I A To:' . Dr. William L. Dunn, Jr. Date: October 16, 1981 From: • Jan Jones Subject: .~~ Nicoltine~~ Retention~lRe~search Proposal the cigarette. We are observing changes in inhalation para- meters in the direction which would suggest compensation for increases or decreases in nicotine relative to the subjject's• usual brand. When smoking the ultra-low nicotine experimental cigarette„ a subject consistently showed a large inspiraltory volume (1.51 t +.A3) and a high mean inspiratory flow rate (1.36 t/sec ±.03)', compared'to a much smaller inspiratory volume (1.11 t- +.02') and smaller meaninspiratory flow rate (1.01 t/sec +.0'2)! for thchighnicotine condition. Weareinterested'inidetermining whether these significant behavioral changes do inifact serve a compensatory function - is the smoker actually receiving,amounts of nicotine from the low nicotine cigarette•comiparable to amounts he obtains from the high - or are the changes related to some other variable such Research on smoke-laden inhalation patterns, using,the ambulatory monitoring instrumentation, has provided prelim- inary evidence that inhalation behavior is modifiable, and is altered as a function of changes in the nicotine delivery of as smoke acceptability. as. 1. Do puff parameters vary as a function of nicotine variables' inf'luencing nicotine retention? The information will be obtained through the coordinated use,of the smoking machine, the puff recorder, the Respitrace system (for inhalation measures), anlexhalant nicotine collection device andia gas chromatograph. Development of the nicotine 4. Which puff and inhalation parameters are the critical 3. Do changes in inhalaition betiavior influence nicotine retention? and if so,, r The proposed line of research will address questions such Ij ~ delivery? 2. Do inhalation patterns vary with puff' patterns'?. :.Y ;'~'..I ...a.. % -.d

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