Length: 10 pages
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Reviews nicotine self-administration models. Indicates further nicotine delivery studies are need to determine reinforcement of smoking behavior and questions what levels are needed to discriminate between a nicotine containing and de-nic cigarette. Suggests smokers regulate nicotine intake by self-administration but wonders whether this is habituation. Asks if there is an extinction level of low nicotine cigarette smokers and suggests nicotine antagonists could play a role in smoking cessation.
Handwritten notes with bibliography.
- Smoking psychology and behavior
- Low-yield cigarettesModification of low yield products to assure that adequate levels of nicotine delivery are maintained, and effects of yield changes on toxicity and dependence.
- Measuring human smoking behaviorMeasuring the effects of changes in human smoking behavior on intake of nicotine and smoke constituents.
- Nicotine transport, transfer, and uptakeDesign changes which alter nicotine delivery or effect how the product causes and maintains dependence, including transfer of nicotine from tobacco to smoke, and uptake into the body.
- Free Nicotine
- Inhalation ProfileAre cigarettes designed to cater to individual inhalation profiles?
- Animal testing
- Human testing
- Central nervous system (CNS)
- Puff frequency
- Smoke Constituent
- Design Component
- Nicotine transfer efficiency (NTE)
- CNS/Brain (Effects)
- Effects—Smoking Behavior (Effects)
- nicotine technology
- nicotine analogues (Technology)
- Pharmacology (Effects)