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M I t ROSTAT ftm•u.-s.rAT.orf. I,q1CROF 1 2' -s• k--y 7, 1941 In other words, -- analpzed the oaliva, which would have otherwieo been swallowod. No nicotinio •oid oo~•urred in the esoker's es.liva Lefore ssaking. 6e feel that we have made this report sufficiently long to cover the discoveries, which we regard as Quits resurkatle. If you have any questions in the matter or suggestions, we will be Elad ::c hoar frcn qou, te would- also be intercatol in lcarnirg ;uur opiniun cf the material for advertising pv8poses, as, of course, this oonstitute. itt principle value. Very trul: yours, Cbmis t ttiddletown Branch. HIiP.ms P. Lorillard Co. f P R E C I S 1 O N- nucE wuK

• PRECISION- TMADEmA-LK Ml't ROSTAT 114•u.s.rAr.as. MlCROFILh 1 2! F. day s, l:T41 IEr. A. Riefner, Secretary - Committee On :u,nufaoture Subjects NiectinN Acid P. Lorillard Coapany 11e. York, 71.Y. Dear Siro Since your Inquiry cf March oth and our reply of i[arch llth relative to the poaaioil:ty of sitamina -existing in Old Gold cig3rettes, permit us to state that e have given the matter quite a little thought and have condueted several experiments. As a result of the latter we feel that we have made certain surprising diacoveries, which, - Af they have'any appeal to our advertising people, might be worthy of more extensive investigation. As you probably know, there ii a vitamin, recently identified as nioo:lnto acid, which when absent from the diet causes blaok-tcn&ue in dogs or pellagra in human be!ngs. Ten to fifteen milligrams dai13 of nicotinio aoid are aeoessary to keep a man from acquiring the disease in question. Thus, in poor sections of the South and in countries, such as Spain after the recent Civil ar, we tind a deficiency of this necessary element us exhibited by a prevalency of pellagra. Since nicotinic aoid can be manufactured by the oxidation of nicotine, since it is readily available at a reasonably low price, and because of Its tavorable physioal properties, we decided to run a few tests on cigarette smoke to see if it was normally present, or If it o amld be added by enrichment of the original tobacco. The tests which we will s-ariae were run on Ri.ple cigarettea, rolled by hand, but Ke f`el sure that the conclusions are equally aoplicable t~ Old Golds. ~ ,

aOLL Ho, t . r •&_ of cigarsttes daily. ! .~ lCay 7, 1941 i In our letter to you of Uaroh llth we mentioned that the presence or absence of vitamins in any material is nsuallT proven by feeding the mat.rial to experisental animals. 1hus, ons would normally find it necesaarT to pass the .moke through water, in which nicotinic acid is soluble, later feeding this water to dogs hald on an -otherwise nicotinic acid free diet. However, with this particular vitamin a ebeaioal test has recently been dsveloped, which indicaten its.prese tGsnd amount without the use of dogs. This test is none too goc:d, but naver- theleas it iiLs bean Eenerally aocepted, and is the basis of the conclusions which we intend to menticn. However, if our advertising people are interested in the proposition, wa still believe that a few animal experiments :ill be necessary or at least advisable. Wa find that the smoke from ordinary Ripple cigarettes eontains the anti - pella3ra vitanin or nicot.inic acid in fairly substsn tial Rmounts. However, the quantity is probably too low for a man to rely upen th:s souree alona for his nicotinic acid requirement. At least to do so he would find it neoessary•to smoke an unreasonable number 'te find that synthetic nicotinic acid can be added to -the tobacco, enriching it as it wsr., thereby increasing the amount in the smoke several fold. In brief, the added ,nicotinic acid oomes over in cha smoke without being destroyed by combustion. You will rtea11 that in eur letter of !larch 11th •e doubted that vitamins oould be absorbed from tobacco smoke by the throat and lung tiasuea. 8owsver, se have now found that niootinio acid is disyolved in the saliva of the smoker when smokirg ordinary oigarettes, and even in greater amounts when smoking cigarettes made from the enriched tobacco. Thus, the vitamin does not have to be absorbed thru the ldngs, but will be swallowed in the approved manner. These conclusions are bas-:d cn actual anal7sss of saliva, collected from a smoker while smoking. r