[Additives, Ames and LD50's]

Product Design

[Additives, Ames and LD50's]

Date: 1980 (est.)
Length: 70 pages
01554383
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Abstract

Lists toxicology, mutagenicity and physiological effects of tobacco additives.

User-Contributed Notes

Fields

Hypothesis: Health effects
Design changes which have measurably altered health effects of cigarette smoke, both for smokers and nonsmokers.; Measuring overall toxicity
Development of scientifically valid protocols and methods for testing the health and toxicity effects of changes in product design.; Toxicity and consumer intake
Development of scientifically valid procedures for measuring biological activity and neurological effects of nicotine and smoke constituents.; Use of additives
Modification of tobacco products through use of additives and measuring effects on dependence, behavior, and toxicity.
Keyword: Animal testing; Carcinogenic (Cancer-causing); Cardiovascular system (Heart); Central nervous system (CNS); Ciliatoxic; Dose-response; Electrophysiological; Inhalation (Smoke inhalation); Irritation (Attribute measure); Lower respiratory tract (Lungs, bronchial tubes); Mutagenic; Physiological effects; Tolerance; Toxicity; toxicology; Tumorigenic
Additive: 2-A-MP; 6-methyl benzopyrene; Ammonia phosphate; Anethole (trans-Anethole); Artificial Dark Chocolate; Artificial marshmallow; Artificial Nut; Artificial Tobacco Flavor; B18; B22; B25; B33; B41; B53; B64; B68; B80; B82; Benzaldehyde; Benzyl alcohol; Cardamom (Cardamom Oleoresin, Extract, Seed Oil, Powder); Carob (Carob Bean and Extract); Caryophyllene (beta-Caryophyllene); Casing 9/706856; Celery (Celery Seed Extract, Solid, Oil, and Oleoresin); Cherry (Cherry Juice, Concentrate); Chocolate liquor; Cinnamon (Cinnamon Bark Oil and Extract, Cinnamon Leaf Oil); Citric acid; Clary sage (Clary Sage Oil); Clove (Clove Leaf Oil and Clove Bud Oil); Cocoa (Chocolate) (Cocoa Shells, Extract, Distillate and Powder)
Composed of nearly 400 identified chemical substances as of 1967; Coriander (Coriander Oil, Extract); Corn silk; Corn syrup (Corn Syrup, Solid, High Fructose, Hydrogenated); Coumarin; Creme de Menthe; Currant (Currant Buds (Black), Absolute); Date (Date Juice); Deer Tongue; Dill (Dill Seed Oil, Extract); Ethoxyacetic Acid; Ethyl vanillin; Flavor No. 7826; Flavor No. 7838; Flavor No. 7932; Flavor No. 7981; Flavor No. 8048; Flavor No. 8133; gamma Terpinene; Genet (Genet Absolute); Geranyl acetate; glycerin; Heptanoic acid; Hexanoic acid (Hexanoic Acid or 3-Hexanoic Acid); Hops (Hops, Hops Oil); Imitation Chocolate Flavor; Imitation Tobacco; Isobutyric acid; Isoeugenol; Lemon (Lemon Oil, Extract); Licorice (Licorice Fluid Extract, Powder, and Root); Limonene (d- Limonene); Linalool; Linalyl acetate; Lorillard Concentrate 2911; Maltol; Menthol; Myristic acid; Nonalactone (gamma-Nonalactone); Nutmeg (Nutmeg Oil and Ground Nutmeg); Octanoic acid; Octanol (1-Octanol); Oil of Almond Bitter; Orange (Orange Oil, Extract, Juice); p-Cresol Methyl Ether; Peppermint (Peppermint Oil); Phenylacetic acid; Pinene (alpha-Pinene or beta-Pinene); Propylene glycol; Prune (Prune Juice & Concentrate); Raisin (Raisin Juice Concentrate); Rum (Rum, Rum Ether, Rum Natural (Non-alcoholic) Extract); SAG 730 Silicone Anitfoam; Sage (Sage, Sage Oil and Oleoresin); Spearmint (Spearmint Oil); St. John's Bread; Sugar, Dark Brown; Tabacarome F-9115; Terpineol (alpha- Terpineol); Tetramethylpyrazine (2,3,5,6-Tetramethylpyrazine)
2,3,5,6-Tetramethylpyrazine; Tobacco 53.415; Tobacco Flavor 2Q-03654; Tobacco Flavor 303.615; Tobacco Flavor 52.644; Tobacco Flavor 53.451; Tobacco Flavor BB-701C; Tobacco Flavor BB-701C; Tobacco Sweetener; Tolu balsam (Tolu Balsam Gum & Extract); Tolualdehyde (m-, p-, and o-Tolualdehyde); Tomato, Artificial 57.635/A; Uncourvan 7450; Undecanal; Vanilla (Vanilla Extract, Oleoresin); Vanillin; Vanitrope; Verataraldehyde; Walnut (Walnut Hull Extract, Leaf Extract); YMSM 2980
Design Component: Flavorant
Named Organization: Loews Corp. (Parent of Lorillard Inc.)
Parent of Lorillard Inc. Owns Loews Hotels, Bulova.; Lorillard Tobacco Co. (American cigarette manufacturer)
American cigarette manufacturer; makes Kent, MaxSatin, Newport, Old Gold, Style, and True cigarettes.
Subject: acids (additives); additives; Ammonia (Additives); Cancer (Health Effects); Cardiovascular Effects (Health Effects); CNS/Brain (Effects); Cocoa (Additives); health effects; Humectants (Additives to maintain moisture); Irritation (Effects); Levulinic Acid (Additives)
reduces the harshness of cigarettes; Licorice (Additives); Menthol (Additives); Pharmacology (Effects); Respiratory (bronchodilation) (Effects); Respiratory Effects (Health Effects); Sugars (Additives)
Glucose/Invert Sugar/Fructose/Sucrose; Test/Animal Subject (Testing); Test/Skin Painting (Testing); Test/Toxicity (Testing)

Document Images

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COMTOUND: Carob Bean Concentrate 340-270& (B69) LDO > 10,000,mg/kg (i.p.) 14-Day Subacute -reh4+rrg '>$qpp~~~A 4, Ames Assay - (Confirmed) ,, Mouse Lymphoma: Rabbit Eye Minimally Irritating Rabbit Eye (low d'ose) Non-Irritant Cardiovasc./Respir. - 5-Day Range-Finder MTD = 5000 mg/kg Enzyme Induction Immunosuppression - SOURCE: Givaudan COMPOUND: Artificial Tobacco Flavor 52.648 (B'70)~ LD50 Ames Assay - (1980) Mouse Lymphoma Cardiovasc./Respir. 5-Day Range-Finder Enzyme Indtction Immunosuppression SOURCE: Firmenich

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COMPOUND: Tobacco 53.458' (B139) 14-Day Subacute Pending Ames Assay - (Contracted) Mouse Lymphoma Cardiovasc./Respir. - 5-Day Range-Finder >5000 mg/kg Enzyme Induction + (male mice) Iimmunosuppression - SOURCE: Firmenich COMPOUND: Corn Silk, Solid Extract (B140) 334/~ 14-Day Subacute P~udizrg / ~ ~~ Ames Assay -(Contracted). Mouse Lymphoma Cardiovasc./Respir. - 5-Day Range-Finder >5000 mg/kg Enzyme Induction + (male mice) Immunosuppressi:on - CONFIDENTTAL AaS SOURCE: Meer

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PROPERTY OF LORILLARD~, A DIVISION, OF LOEWS TIiEATP,ES, INC. CONFIDENTIAL,- DO NOT DISCLOSE This Book/Document contains information which would not customarily be disclosed by Lorillard, including trade secrets andiconfidential information. Neither this book nor any part of it may be reproduced, used' or disclosed, nor may it be removed'from Lorillard's premises without Lorillard's express written permission signed by Dr. A. ja. Spears, Dr. F. Ji. Schultz or Dr. PI. J. Minnemeyer. Wrongful disclosure or use of this book or its contents may constitute a criminal offense.

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COMPOUND: Artificial Dark Chocolate 3711 (B7) LD50 6376 mg/kg (i.p.) Ames Assay - Mouse Lymphoma: Rabbit Eye Rabbit Eye (low dose) Cardiovasc./Respir. 5-Day Range-Finder Enzyme Induction Immunosuppression SOURCE: Crompton-Knowles COMPOUND: Artificial Coumarin 2749 (B8). LD50 1292 mg/kg (i.p.) Ames Assay - Mouse Lymphoma Rabbit Eye Rabbit Eye (low dose) Cardiovasc./'Respir. 5-Day Range-F:inder Enzyme Induction Immunosuppression SOURCE: Crompton-Knowles

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C(:MPOUND: Oil, Cardamon (B9) LD50 757 mg/kg, (i.p, ) 14-Day Subacute 1337 mg/kg (males, i.p.) 1105 mg/kg (females; i.p.) Ames Assay - (Contracted) Mouse Lymphoma - Rabbit Eye Non-irritant Cardiovasc./Respi;r. - (Insoluble according to memo-of 7/2/83) 5-Day Range-Finder MTD '= 5000 mg/kg (males) MID = 2500 mg/kg (females) Enzyme Induction + Immunosuppression~ - SOURCE: Norda COMPOLIDID: Oil, Coriander (Bl0) ED 50 1440 mg/kg (i.p. ) 14-Day Subacute 1254mg/kg (males, i.p.) 1001 mg/kg (females, i.p.) lames Assay - (Confirmed) Mouse Lymphama - Rabbit Eye Severely Irritating Rabbit Eye (low dose) Minimally Irritating Cardiovasc./Respir. - (Insoluble according to memo of 7/2/82) 5-Day Range-Finder MTD = 2500 mg/kg (males) MTD = 1250' mg/kg (females) E-izyme Induction Inntunosuppression SOURCE: Crompton-Knawles; Polarome; Aroma Resources

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COMPOUND: 021 of Clary Sage (B'll) LD50 LL262'mg/kg (i.p.) Ames Assay - Mouse Lymphoma Cardiovasc./Respir. 5-Day R'ange-Find'er Enzyme Induction Immunosuppression SOURCE: Ungerer COMPOUND: 6-Methyl Benzopyrone (B12)~ LD0 14-Day Subacute Ames Assay Mouse Lymphoma > 7001mg/kg (p.o.) Pending - (Contracted) - Rabbit Eye - Cardiovasc./Respir. 5-Day Range-Finder Enzyme Induction - (Insoluble according to memo of 10/1i9'/83) MTD = 750 mg/kg (males) MTD = 375 mg/kg (females) 0. Immunosuppression - SOURCE: Givaudan; Norda 1-+ C11~ f!1

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COMPOUND: Lorillard Concentrate 2491* (B13) 14-Day Subacute >5000 mg/kg (ip) Ames Assay - (Confirmed) Mouse Lymphoma Card'iovasc_/Respir. - 5-Day Range-Finder MTD = 5000 mg/kg Enzyme Induction - Immunosuppresszon - *Consists of B27, B75, B43, B3', B29, B63, and B12 SOURCE: Lorillard Flavor COMPOUND: Imitation Chocolate P-4482 (B14) LD50 Ames Assay Mouse Lymphoma Card'iovasc,/Respir. 5-Day Range-Finder Enzyme Induction Immunosuppression SOURCE: Kohnstamm CONFIDENTIAL

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COMPOUND: Chocolate 13169 (B15). LD 5& Ames Assay Mouse Lymphoma Rabbit Eye Rabbit Eye (low dose) Cardiovasc./Respir. 5-Day RangQ-Finder IIzzyme Induction Iminosuppression SO[JRCE : Naarden COMPOUNID: Crem de Menthe Concentrate F-2475 (B16) ID5O, Aines Assay Nbuse LynphcÂ¢na Rabbit Eye Rabbit Eye ( To`a dose ) Cardiovasc./Respir. 5-Day Range-Finder Enzyme Induction Im=osuppression SOURCE: Givaudan

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