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C;U1POLJ?,'D': Oil, Cardcr.on (B9 ) LD50 757 mg/kg (~.p.l 14-Day Subacute 1!337' mg/kg (rrales, i.p. ). 11105 mg/kg (females; i.p. ) P,n+es Assay - (Contracted) Mouse Lymphoina - Rabbit Eye Non-irritant Caxcliovasc. /Respir. - (Insoluble accordii:g to menmo of 7/2/83)' 5-Day Range-Finder VI'D = 5000 mg/kg (males) NlI'D' = 2500 mg/kg (females) IIzzyme Induction + Imminosuppression - SOURCE: Norda CC?ri'POLNID: Oi1, Coriander (B10'). LD50, 1440' mg/kg (i.p. ) 14-Day Subacute 1254 mg/kg (anales, i.pj 1001 1 mg/kg (females, i.p.) Ames Assay - (Confirnmd), Mouse Lymphoma - Rabbit Eye Severely Irritatingi Rabbit Eye (,low dbse) Minimally Irritatingi Cardiovasc./Respir. - (Insoluble according to rre,mo of 7/'2/82). 5-Day Range-Finder NFI'D = 2500 mg/kg (males) NII'IJ = 1250 mg/kg (~females), Enzyme Induction Immunosuppression SCURCE: Crorrpton-Kncxwles; Polarorne; AromaiResources

COMPOU3v'D: Alcohol (C-8) (Octanol-1) (B103) 14-Day Subacute Pend'ing Ames Assay - (Confirmed) Mouse Lymphoma - Rabbit Eye Severely Irritating Cardiovasc./Respir. - 5-Day Range-Finder MTD- } 5000 mg/kg Enzyme Induction 0' (female mice): Immunosuppressi!on - SOURCE: N'aarden (RY28000) ; G'3:vaudan COMPOUND: Aldiehyde (C-11),TO-UP4decenal (B.104!)* LD50 Ames Assay - (1981) Mbuse Lymphoma - Rabbit Eye Mildly Irritating, Cardiovasc./Respir. Insoluble Multi-Dose Range-Finder MTD' =~ 5000'mg/'kg, Enzyme Induction I - (sleep times)**' Immunosuppxessd:on . SOURCE: Aldrich Chemical Co.. *Testing stoppedl 7'/83 *'*Insufficient d'ata to evaluate in vitro studies due to toxicity in the,rat ***Higher mean spleen weights in B104 - treated mice

COMP'OUND: Lemon Oil,, Naardenized 06069 (B'10S)* LD50' Ames Assay Mouse Lymphoma Rabbit Eye Cardiovasc./Respir. 5-Day Range-Finder Enzyme Ind!uttioni Immunosuppression, - (1981) ' Moderately Irritating MTD = 3750 mg/kg (male rats) > MTD' = 5000 mg/kg, (female rats)'. MTD = 15001mg/kg (male mice) MTD = 750!mg/kg (female mi,ce)', 0 SOURCE: Naarden *T'e~sting, stopp~e~~d 4/8'3I COMPOUND: d-Limonene:„ P&F (BD02'). 14-Day Subacute Ames lissay Mouse Lymphoma Rabbit Eye Cardiovasc./Respir. 5-Day Range-Finder Enzyme Induction Immunosuppression Pending - ('Confirmed), Minimally Irritating MTD = 1'7501mg,/,kg (males) MTD = 750 mg/kg (',females). 0' (females),, - (males)'. SOURCE: Naarden (RY26331) ;, Glidden ('.SCM,Terpene P'rodlucts)'

C(?;iPOUND: OlI, Cardlamon L00'689 (B1'15). LD50 Ames Assay - (Confirmed). Mouse Lymphoma - Rabbit Eye Mildly Irritating, Rabbit Eye (low dose), * Cardi:ouasc./Respir. - 5-Day Range-Finder MTD =:3125' mg/kg, (males). MTD' = 3!75'0 mg/kg (femal!es)' Enzyme Ilnduction + Immunosuppression - *Not retested since usage level x 100 ex,ceeds tested dose SOURCE': 1Vaarden, COiTOUND: Caramel - Flavor "T" (B'1'16) LDG >4320 mg/'kg, (i.p.)l 14-Day Subacute Pending Ames Assay - Mouse Lymphomal Rabbit Eye Minimally Irritating Cardiovasc./'Respir. - y 5-Day Range-Finder MTD = 5000 mg/kg, Enzyme Induction Immunosuppression SOURCE: Sethness Products

COiU?OUND: Geranyl Acetate RY25091 ('B1'07). LD'5,0 Ames Assay - ('.Conf'irmed) Mouse Lymphoma + (with~Activation). Chromosomal Aberration: - Rabbit Eye Minimally Irritating Rabbit Eye (lowdose)' Minimally Irritating, Cardiovasc./Respir. - > 5-Day Range-Finder MTD = 5000 mg/kg (rats): >. MTD = 2'500 mg/kg (mal'e, miice)~ > MTD = 1875 mg/kg (female mice)' Enzyme Induction + Immunosuppression - SOURCE: Naarden. COMPOU'ND:~ 2-A-3MP' ('B10'8)' LDS0 (Rats, p.o.,) 448 mg/kg (females) 529 mg/kg,(combined sexes). LD50 (Mice) 450 mg/kg (i.p.) Ames Assay - (Conf irmed!) Mouse Lymphoma - Rabbit Eye Moderately Irritating Rabbit EXe(lowd'ose)'Min~imally Irritating, Cardiovasc./R~esir. -5rDay Range-Finder MTD1= 375 mg/kg (males) MTD,= 313 mg[kg, (females), Enzyme Induction -* Immunosuppression - 14-Day Toxicity** Significant increase in absol~;ute and relatiive liver weights in 200 mgf kg, femaies *Significantly iincreas d liver/bod'y wt. ratio (both:sexes)' **5D,1001, and 200 mg/kg, SOURCE: Pyrazine Specialists

CO:-fPOL'ND: Myristic Acid' (B99) LD'50 Ames Assay -(Contracted) Mouse Lymphoma - Rabbit EyeModerately Irritating Rabbit Eye (low dose) * Cardiovasc./R'espir. - ~ 5-Day Range-Find!er MTD = 5000 mg/kg, Enzyme Induction - Immunosuppression - *N'ot retested since usage level x 100 exceeds tested dose SOURCE: Naarden (RY27640); Eastman Organic Chemicals COMPOUND: Peppermint Oil N02923' (E'100). 14-Day Subacute 7$5 mg,/kg, (Males, ip)! 7'11' mg/kg (females, ip). Ames Assay - (Confirmed)~ - Mouse Lymphoma Rabbit Eye Moderately Irritating Cardiovasc./Respir., -5-Day Range-Finder M1TD = 175&mg/kg Enzyme Induction Immunosuppression + SOURCE: Naarden

COMPOUND: Heliotropin, Extral (B29) LD , 940 mg/'kg,(males) (i.p.). S 906 mg/kg (females) (i.p.) 14-Day Subacute 1055~ mg%kg ('combined' sex, ip) Ames Assay - (Confiirmed)' Nibuse Lymphoma - Rabbit Eye - Cardiovasc./Respir. - 5-Day Range-Finder MTD = 1375 mg/kg, (males), Iy4TD = 7501mg/kg (females) Enzyme Induction 01 Immunosuppression - SOURCE: Norda COMPOUND: Lovage Oil 030). LD'50 14-Day Subacute E'end'ing, Ames Assay - (Pending). Mouse Lymphoma Cardiovasc./Respir. Insoluble Multi-Dose Range-Finder Pendiing, Enzyme Induction Pending, Immunosuppression Pendiing, S'OURCE: Polarome

COMPOUND: Chocolate, Artificial (7M02'6119)' (B87) LD© > 1000,mg/kg ('i.p.) 14-Day Subacute > 5000 mg/kg (',ip) Ames Assay - (Confirmed) 4 Mouse Lymphoma - Rabbit Eye Miinimally Irritating, R'abbit Eye (low dose) * Cardiovasc./Respir. - > 5-Day:Range-Find'er MTD1= 5000 mg/kg, Enzyme Induction 0 Immunosuppression - *Not retested since usage level x 100 exceed's tested dose SOURCE: Naarden COMPOUND: *~Walnu~~t~~ CD79429: (B8'8) )~ (Formulation C'hange~ - N'~ew~ #$~113~). LD 0 > 8640 mg/kg, ('i.p.) Ames Assay - (1977) Mouse Lymphoma Cardiov'asc./Respir. ~ 5-Day Range-Finder MTD = 5000 mg/kj Enzyme Induction Immunosuppression *Testing stopped 1/26/82 SOURCE: Naarden

COMPOUND: Oil, Nutmeg,, East India Select ('B39)' LD'50 1593 mg/kg (i.p.) 14-Day Subacwte 2743 mg/kg,(males, ip) 3001 mg/kg,(females, ip) Ames Assay - (Confirmed)~ M©use Lymphoma - Chromosomal Aberrationi - Rabbit Eye Non-irritant Cardiovasc./Respir. - 5-Day Range-Finder MTD = 3125'mg/'kg,(males) MTD = 1750 mg/kg ('females) Enzyme Induction + Ilmmunosuppression - SOURCE: J. Manheimer; Flavor Resources COLIPOUND': New England Rum Flavor SA 90562' (B40) *(replacedl by B109). LD5O Ames Assay Mouse Lymphoma Cardiovasc. /'Respir. 5-D'ay' Range-Finder Enzyme Induction Immunosuppression SOURCE: hlaarden *testing stopped16/82