Product Design
A Study of the Puff-by-Puff Delivery of Menthol and Nicotine in Cigarette Smoke and the Effects of Air Dilution on Delivery
Abstract
Reports a simple extraction method for the simultaneous measurement of nicotine and menthol. Says this method is used to study the effects of air dilution on puff-by-puff deliveries of nicotine and menthol. Finds increased air dilution enriches the nicotine content of tar more than menthol and this procedure is useful for analyzing cigarette filler.
Fields
- Author
- Shoffner, R.A.
- Recipient
- Ireland, Mary Sue (Lor, Product Composition Chemist, 1965)
- Minneme, H. J.
Supervisor of- Schultz, Frederick J., Ph.D. (VP of Lorillard, Inc. '89-95)
- Tucker, Charles. L., Jr. (Lor, Product Development Manager, 1979-1983)
- Minneme, H. J.
- Hypothesis
- Elasticity and Product Control
- FTC machine testing and ratings
Design changes to achieve altered FTC smoke machine tar and nicotine ratings, with or without measured changes in human intake.- Low-yield cigarettes
Modification of low yield products to assure that adequate levels of nicotine delivery are maintained, and effects of yield changes on toxicity and dependence.- Nicotine transport, transfer, and uptake
Design changes which alter nicotine delivery or effect how the product causes and maintains dependence, including transfer of nicotine from tobacco to smoke, and uptake into the body.- Use of additives
Modification of tobacco products through use of additives and measuring effects on dependence, behavior, and toxicity. - FTC machine testing and ratings
- Keyword
- Menthol delivery (Smoke menthol, menthol yield)
- Per puff delivery
Per puff tar, per puff nicotine, and per puff CO- Puff parameters
- Total particulate matter (TPM or Tar)
- Per puff delivery
- Additive
- Menthol
- Triacetin
- Smoke Constituent
- Anethole
- Menthol
- Neophytadine
- Nicotine
- Total particulate matter
- Menthol
- Design Component
- Air dilution
- Perforated tipping paper
- Pressure drop (PD, Resistance to draw (RTD), Flow rate or Draft)
- Tipping paper
- Perforated tipping paper
- Named Organization
- Filtrona
- Hewlett Packard
- Lorillard Tobacco Co. (American cigarette manufacturer)
American cigarette manufacturer; makes Kent, MaxSatin, Newport, Old Gold, Style, and True cigarettes. - Hewlett Packard
- Technology/Method
- Binary organic solvent system
- Cambridge filter pad
- Direct extraction
- Filtrona 12-port smoking machine
- Gas chromatography
- GC/FT-IR
- GC/MS
- Cambridge filter pad
- Brand
- Carlton (ATC)
- Doral (RJR)
- Golden Lights
- Kool (BW (1933-2003)/RJR (2003-present))
First Menthol cigarette line, released in 1933. Premium priced brand.- Merit (PM)
- Newport (Lorillard)
- Salem (RJR)
- Triumph
- True (Lor)
- Doral (RJR)
- Subject
- Menthol (Additives)
- Puff Count (Measures)
- Smoke Delivery/Transport (Measures)
- Smoke Nicotine (Measures)
- Test/Smoke Machine (Testing)
- Ventilation (Design)
- Puff Count (Measures)
Document Images
'TABLE 7 - AIR DILUTIONvs. YIELD REDUCTION
00783802
Pressure % Air
- % Yield Redu-ct}on_
-
Ti~~- in_ PapEr
-
-
~ Drop__ __ Dilution Tar_ __ Menthol N~.EOtln
~
.
-
Non Porous 122 0 0 0 0
1 Line Perf. 103 2~0 12.4 10.5 4.8
3 Line Perf. 94 30 31.4 26.9 13.8
6 Line Perf. 90 40 40.1 34.3 20.0
9 Line Perf. 83 50 52.1 44.8 44.1

FIGURE 1.
T E MI'F 1 170 ' 17B,
T I M'~E 1 00.0
1't1J TER.1:-~ 2501 5',,
FID
RLE;::' TEMP
TEMP 2 t. 0'
o 2 ; a
s;
CG w E H th1 RX 20!11. ,
C'H T SRn 0 . E. 22"
RT T M 2't. 12
FIh wGei!L +F:
SL F SE N'S Ei. sFi
Hl".;EN'. R'E_J
F L OV1' tyl a.
FLOW E 13
OPT. H 13
2'. 5 FiTTH'; ;?'-fi
2'. 5 F;REw F"E-i,
16. ..~-~, S'T Or
Helium Flow R:ate -
Air Flow Rat-e -
Hydlroqen Flow Rate -
33 ml/min
2'S0 mS:/mim
4!0 ml/'min

2,22 Menthol
4.61 Anethole
,
~ 5.53 Nieotine
- - - - -
6.49 Ne$pMytadiene
\

:ij i It ;III t I ~L:I jr rl' j i~j rltl {{ L I l l'' '1 2 1 l +' t t ~l_{i l iL ' r r" i~' Il Q
t ~ 11i ~~~. Il' i tl
1 l+f~ r'
11
1,
~
I~ }it,
t
. .
ift,
00 /
38%
. lt t
1 ~I,! l " I t 1 , I~ r 1 ,t' d 0
~ ~ I ~ ~
~
~
~
i(.
7
~
7 '
. I '
Tj
i
L. ~ t
t
~
t 1 H
i tt ~1
I i i t
1 ;
a ~
k I i I 1 t
~ [ L ~ 1_ ~ :
f
t L
i i
M oz
l ~
a W
L 7;
ti ~
, i
i: I II ,
I_
l
~ ~
i I --i~
j ~ I
-
1
,
-
. W
tD W
:
,
w
l
~t :,
:
EL .:i r;
;llL
}1' I
tt
I $ l ;: N Pq. i' . i , ; t ~ t i li I L I L .
-~.. _ w t
.
, t , ' , t ~~±~ : -~ !
~
;
.
i :
T; t t t ~ ~
~
~
~pl
- - r--
1
(r1t
l'
l
l i
i I
;t'
lt r' r i+
1
t1 j r r t tr !l 1; ~1
t
.
t.l ! l y .
frl
I'
(
g
i
~ } _
ii I
I
r t :
1~
{ ~ I l
i i
fi. II' ( t ; I I I i I -
1
I j j t t t, l 1'
! L
di
IL 11 (Il: I L ~
I
r~ ~ 1
a
W) 70HaLN3W
,a
h
0!-NOPSY Y313MIIN35 3NI Ol 01 Y Ol 3YYNOT ~!,~' ; t"'Ay1'~J ~M"11^p NUi,vucw,ao u a,rti~u ~,ann,n
jti~Tq~r ~~ +;~ ~
~ ~

r
t 1;JJ ~,{{l , '.,'
~,
i
,
t
~
fl
f
I
T~1T-
~
777 ;
1 ' ;i ro
I
^i:
+1
-
=1
1
0
0
1
I
!
,
,
9QeEQ4Q0
!
1
I
I
I
1
1
-p
0
~
,
h
1
a
1
f
I
~- . .., ,...y ..._. ,
CowoHdiijrt
f ,a S'. ~F 4 y7 &H,tiWac CoNrAr7ts
!. . . ~ Vm U$ A "
. . - -¢4W n. . . - .
U
<GuN+~.ti~4wYwk (.,f ! . SOUAAE 10 !l 10 T0 TNE CENTII1ETEt ASa0u-c0
ME1lIT-NOL CA9)
~
$
0

,..;
~~...~.-
=( j
~-- 1.
0
0
0
~
...,--
~- -
1
--- .
~
_.. ._ _... _ . . _ _ __ _ ..,.
1 1
r=- t
-~ ::i ~ ~: L t ( } I
,
- - -~# - - - --- ._ L
-- ~ - ---~-- -- =~- -- -- --- _. ._-- --_ __ . --
,
. . . ..~
-- -- --~ ~ -- -
--
--
---- - -
- t _
r:--
-
: - MFh/IrAer L=6mlr
_~` --- _~-# - --= -- -- : ' -^ - .. #:-- ---~ -_~ -=- f== ------ -- r -_
~.- -- -- --_--- -
} t ,
r r - -
- r=1 c= i :::
_: 77 _ ~#. -i
_ _ - - _ = r==
-- - -:=r_-._
- -- - -
0
0
0
0
0
:
#'._.. . . r. `
f :
Hr
.,.
E. . t7--
0
0
0
0
0
0
~-~--
-~.
t
{
/_--
i
- Lr
-t
t
I
r=:
t
I
r
r
E
1 ..
1
_L=
1
c,ocVrwL4007 a
i
r
E
a
T~R1~6
:i~..l.:. :. l ::.;.---i~----
t
~ ..
T-'
r._..
~
i
i
.:I I .#:.. _.
a
;.a
,~, .,..
PUFF N'ufi+BSIR
~+btDc~!r1.
: ~ss»r ~no

0
{
I
I
i
I
t
{
I
r
1
i
1
i
t
I
i!
'r~
'1
ll
t
1
liT,
t
t
i
0
{
t!~
4
c
1
l
I
r
6
J
1
~
{
'itI 1 {i
>I
I
1
a-
, _ j....
{
1
1'I
Ili
i
1
't'
I
v~:nr., r y
09 11D6 SY 1)13NI1H39 191 Ol Ol X Ol 31YDDi
A."X +*'N NOI tV147dI~tiZ) s~ rrtNOO 3"vM [H3 +V,/ Nava; ~
t{t
4
n
t

r
VI u
CHANGE IN DELIVERY WITH
INCREASINGIAIR DILU'TION.
i
70
20~ 30 40~, 5101, 60
% Air Di1
ution
70
80
_ . . ....~..~~..~~ . _._~~. ~ .. .. ._.w,...

- --_- -_I_-- -_ -
--r - -- - -
_ - -- ;- ~ - ~ ~ --
_
7 7
~~. - = r -t t ;: E-: { }
i-:
=~_ _::~-:
- ~-- -

D.
~
0
L -
`FIGURE
t.--
_-PUFF-BY-PUFF' laELIVERY
kOF'-Zr1IC0'TI1VE'~
PERIMEiJTAL---CI GARETTES-
~.._:, _
=t
~-
-«-
1
2
1--
c
r
i
,
r
.-t
t
. F .
L
F=
;
,
T
t
t
-1 463
..__ t .
t
t
rso
^
~
~
4
P'u'F,F I!vU!M 13ER
