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COMPOUND': Artificial Cburmarin 13568640 (B21) LD50. Ames Assay Mouse Lymphoma Rabbit Eye Rabbit Eye~ (low d'ose) . Cardiovasc.%Aespir. - 5-Day Range-Finder Enzyme I[nduction Immunosuppression SOURCE: International Flavors & Fragrance& C6MROUND:(B22IS A DUPLICATE OF B10), . . •~. LD50 Ames Assay Mouse Lymphoma Rabbit Eye Rabbit Eye (low dose) Cardiovasc.['Respir. 5-Day Range-Find'er Enzyme Induction Immunosuppression SOURCE:

COMPOUND: Artificial Date F-5715 (B23) LD5© 2422 mg/kg (i.p.) 14-Day Subacute Pending, Ames Assay - (Confirmed)i M'ouse Lymphoma *Rabbit Eye (low dose) Minimally Irritating Cardiovasc./Respir. - 5-Day Range-Finder MTD' = 3750 mg/kg, (males). MTD' > 5000' mg/kg, (females). EnzymeInduction+ (mice only) Immunosuppression - *Test only at low dose since pH = 2.79' SOURCE: F~i'rmenich COr:FZiDENTIAL COMPOUND~: Oil of Dillweed Extract (B24) 14-Day Subacute Pending LD50 1150' mg/kg (i.p.). Ame&Assay - (Confirmed) Mouse Lymphoma Rabbit Eye Minimally Irritating, Cardiovasc./'Respir. Insoluble 5-Day Range-Finder MTD >= 5000 mg/kg (males)'. MTD:a 3125 mg/kg (females) Enzyme Induction 0 l;. Immunosuppression - SOURCE: Fritzsche O OI 'A tJ' hJ'

COIKP©UND: (B25. IS A DUBLICAZIE OF B3) LDS0 Ames Assay Mouse Lymplioma Cardiovasc.,/,Respir. 5-Day Range-Finder Enzyme Induction Immunosuppression SOURCE: COMPOUND: Lorililard! Concentrate 2911* (B26)' CONFIDENTIAL 14-Day Subacute 285:4 mg/kg (males and females, i.p.) Ames Assay - (Confirmed) Mouse Lymphoma Rabbit Eye Severely Irritating Cardiovasc./Respir. - 5-Day Range-Finder MTD' = 3750 mg/kg,(males). MTD > 5000mg/'kg, (females) Enayme Induction - Immunosuppression - *Composed of B9, B'1U, and B39, SOURCE: Lorillard Flavor O 0 o. ~ ~ N N Ob

COMPOUND: Chocolate, Artificial (B27). LD50, 2147 mg/kg (i.p~.)' 14-Day Subacute (ip) <1540 mg/kg (liver pathology noted')' 14-Day Subacute (oraL) >5000:mg/kg Ames Assay - (Oonfirmed)M'ouse Lymphoma - Rabbit Eye + Rabbit Eye (low dose)' Minimally Irritating, Cardiovasc./Respir. - 5-Day Range-Finder MTD > = 5000 mg/kg, Enzyme Induction 0 (females), - (males) Immunosuppression - SOURCE: Firmenich COMPOUND: Glycerine 9'9'.5%, USP -#7 Flavor (B28)' LD'50 tlines~~ As~~say~ - (1970 PMouse Lymphoma Card'iovasc.,/Respi:r., 5-Day Range-Find'er Enzyme Induction ImmunosupPres~~s~~ion SOURCE: Proctor & Gamble FEMA 9.5a 9 i

CONFIDENTIAL COMPOUND: Heliotropin, Extra ($2'9). Fc.wlA aq 1 I' LDSa 9'40 mg/kg (maLes) (i.p. ). 906 mg/kg (females) (i.p. ) 14-D'ay Subacute 1055 mg/kg (combined sex, ip) Ames Assay - (Co:nf irmed) Mouse Lymphoma - Rabbit Eye - Cardiovasc./Respir. - 5-Day Range-Finder MTD = 137'5 mg/kg (males)'. MTD = 750 mg/kg (fema]Jes). Enzyme Induction 0 Immunosuppressi:on SOURCE: Nordai COMPOUND: Lovage Oil (B30) F511174 01105;1 14-Day Subacute 374 mg/kg,(males, i.pi.) 465 mg/kg (females, i.p.) Ames Assay - (Confirmed). Mouse Lymphoma Cardiovasc./$'espi'r. Insoluble Multi-Dose Range-Finder MTD = 313 mg/kg (males) MTD' = 375 mg/kg (females). Enzyme Induction Pending, Immunosuppression Pending, SOURCE: Polarome ~ y

COMPOUND: Licorice, Extract - #1001 Flavor (B31)~ LD0 > 10'00 mg/kg (p.o.) 14-Day Subacute 3349 mg/kg (males, ip) 2299 mg/kg, (f emales , ip)' CONFIDENTIAL ren.4 a6A? Ames Assay - (Contracted) Mouse' Lymphoma +(with&withoutActivatiionY Mouse Lymphoma (Rerun) Pending Chromosomal Aberration + (;With Activation). Rabbit Eye Mildly Irritati'ng, Rabbit Eye (low dbse) Cardiowa!sc. /Respir., * 5-Day Range-Finder MTD = 51000'mg/kg. Enzyme Induction 0~ Immunosuppressi'on - * Not retested'since usage level x 100' exceedls tested dose SOURCE: MacAndirews & Forbes COMPOUND: Licorice, Artificial (50.691/A) (B32)' 1041 mg/kg (i.p.), LD SO 14-Day Subacute. Ames Assay Mouse Lymphoma Mouse Lymphoma (R'erun)i Rabbit Eye Rabbit Eye (low dbse) Cardiovasc./Respir. 5-Day Range-Finder Enzyme Induction. Immunosuppressilon SOURCE: Firmenich 637 mg/kg,(males, ip). 679~~ mg/kg ('~females,~ i'p), - (Cbnf irmed) + (with & without Activation) Pending Severely Irritating, Minimally Irritating, 0 (yCO) (Test #1) 0~ (;+TV~)~ (Test ~~ #2) , Insoluble according to memo of 7'/2/8'2 and 10/'11/83' MTD,= 1375 mg/kg y

COMPOUND: (B33 IS' A DUPLICATE OF B31)'. L.D50 Ames Assay 'Mouse .Lymp}homa R'abbit Eye Rabbit Eye (low dose)'. Cardiovasc,/Respir.5-Day Range-Finder Enzyme Induction Ihnmunosuppression SOURCE: COMPOUND: Maltol (B3'4). LD50 . Fr=M,A A'~54 Ames Assay Mouse Lymphoma Rabbit Eye Rabbit Eye (low dose)' Cardiovasc./Respiir. 5-Day Range-Finder Enzyme Induction Immunosuppressiion 11 SOURCE: Naarden

COMPOUND: Menthol,, BraaiLian (USP) (B35)'. (NOTESTING) LDQ > 1000 mg[kg (p.o.). Ames Assay Mouse Lymphoma Rabbit Eye Severely Irritating Rabbit Eye (low dose)~ CArdiovasc./Respir.- 5-Day Range-Finder MTD=1'~250 mg/kg Etixyme Induction + Immunosuppression - APPROVED BRANDS: Braswey, Bwddha;, Brasmenthol APPROVED SOURCES: I.R. Boody; J. Manheimer; George Uhe Co.; Biddle-Sawyer COMPOUND': 1-Menthol, Synthetic (B36)'. (NO~ TESTING) LD50 Ames Assay - Mouse:Lymphoma Rabbit Eye - Rabbit Eye (low dose) Cardiovasc./Respir. 5-Day Range-Finder Enzyme Indhcti'on Immunosuppression SOURCE: Takasago; Haarmann & Reimer . P

C0MP0UND: Artificial Marshmallow 59.360/A (B37) 14-Day Subacute Pending Ames Assay - (',Confirmed)' Mouse Lymphoma Rabbit Eye Moderately Irritating Cardiovasc./Respir.. 5-Day Range-Finder MTD'= 3750 mg/kg (males) MTD' = 3125 mg/kg, (females) Enzyme Induction Immunosuppression - SOURCE: Firmenich C0NfP0UtQD: Artificial Nutmeg (B38) LD50 T736 mgJkg (,i.p.)i Ames Assay - Mouse Lymphoma Cardiovasc. /'Respd:r . 5-Day Range-Finder Enzyme Induction. Immunosuppression C OriT'FID ENT IAL SOURCE: Ungerer. ~ y

COMPOUND: Oil, Nutmeg, East India Select (B39) LDg0 1593 mg/kg (i.p.) 14-Day Subacute 2743 mg/kg (males, ip) 3D0'1 mg/kg (femalles, ip) Ames Assay - (Conf irmed) Mouse Lymphoma - Chromosomal Aberration - Rabbit Eye Non-irritant Cardiovasc.,/Respir., - 5-Day Range-Finder MTD = 31i251mg/1cg (males), MTD = 17501 mg/kg, (',females). Enzyme Induction + Immunosuppression - FF=h,A a7q3 SOURCE: J. Manheimer, Flavor Resources COMPOUND,: New England!Rum Flavor SA 90562 (B40) *(replaced'by B109) LD , S0 Ames Assay Mouse Lymphoma Cardiovasc./Respir. 5-Day Range-Finder EnzymeInd'uction Imnmunosuppressi:on SOURCE: Naarden *testing stopped16[8'2 ` O. O. .~ W ~'