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COMPOUND: Oil of Anise-USP(B'1) Il,D50 868 mg/kg (i. p. ) Ames Assay Mouse L.ymphoma Rabbit Eye Rabbit Eye (low dose) Cardiovasc./Respir. 5-Day Range-Finde.r Enzyme Induction Immunoswppressio!n - SOURCE: Magnus, Mabee &' Reynard; Ungerer (#2856) COMPOUND: Alcohol-Specially Denatured (190 Proof) (B2') (NO 'LESTING)~ Z.D50 Ames Assay Mouse hymphomal Rabbit Eye Rabbit Eye (low dose). Card'iovasa. /'Respir. 5:-Day Range-Finder .EnzymeI[nduction Immunosuppression SOURCE: U.S. Industrial; Union Carbid'e; Publicker; Shell; Devon r

COMPOUND: Benzodihydropyrone CONFIDENTIAL (B3) C-f A ' 38f 2' 0 r . f LD'50 694 mg,/'kg,(i.p.) 14-Day Subacute (i.p.). 774 mg/kg (males)'. 7111 mg/kg (females) ;1 :01 Ames Assay Mouse Lymphoma Mouse Lymphoma (Rerun) Chromosomal Aberration Rabbit Eye - (Confirmed)l + (With Activation)'* Pending, + Rabbit Eye (low dose)' Cardiovasc./Respir. 5-Day Range-Finder Enzyme Induction Minimally Irritating MTD = 3125 mg/kg,(males). MTD' = 1376 mgfkg, (females). - Immunosuppression - *We k + a SOURCE: Givaudani; Arsynco COMPOUND: Balsam Tolu! (B4)' Il.D50 Ames Assay Mouse Lymphoma Cardiovasc./'Respir. 5-Day Range-Finder -(Con€irmed)'. Insoluble . Enzyme Induction .~ Immunosuppression SOURCE: J. Brampton O O. O. Q? 2v~ N

COMBOUND:~ Artificial Chocolate 59~~.~457' (B5)~ . LD50' ..1004 mg/kg (i.p.) Ames Assay - Mouse Lymphoma Rabbit Eye Rabbit Eye (low dose) Cardiowasc.,/Respir. 5-Day Range-Finder Enzyme Induction Immunosuppressiom SOURCE: Firmenich COMPOUND: Artificial Coumarin 2134 ($6) LD50 1085' mg[kg, (i.p.) Ames,Assay - Mouse Lymphoma Rabbit Eye Rabbit Eye (,low dose)i Cardiovas~~c. ~/'~Respir~. 5~-Day Range-Find6r Enzyme Induction Iimmunosuppress3on SOURCE: Crompton-Knowles P

COMPODND:! Artificial Dark Chocolate 377IIl (B7). LD5© 6376 mg/kg, ( i. p. )_.._ Ames Assay - Mouse Lymphoma Rabbit Eye Rabbi't Eye (low dose) Cardiovasc./Respir. 5-Day Range-Finder Enzyme Induction. Immunosuppression. SOURCE: Crompton-Knowles COMPOUND': Artificial Coumarin 2749 (B8'). LD50 ll29'2 mg/kg (i.p. ) Ames Assay - Mouse Lymphoma Rabbit Eye Rabbit Eye (,low dose) Cardiovasc./'Respir. 5-Day Range-Fi'ndier. Enzyme Induction, Immunosuppression, SOURCE: Crompton-Knowles .r:

C:CNPOtND : Oil Cardaaan (B9) , LD5Q 14-Day Subacute Ames Assay Mouse Lymphana FEnA aa-4 f 757 mg/kg (i.p. )' 1337 mg/kg (males, i.p.) 1105 mg/kg (ifemales; i.p. ). - (Cbntracted) - Rabbit Eye Cardiovasc. /1Respir. 5-Day Range-Finder Enzyme Induction Non.-irritant. - (Insoluble according to naewof 7/2/83) MTD'= 5000 mlg/kgj(males) IuIID, = 2500 mg/kg, (females) + Intrnuwsuppression - SOURCE:NordaCONiPOUNID : Oil, Coriander (810') FEM ~~,, 3 3 q LD50, 1440 mg/kg ('i.p.), 14-Day Subacute A:nes Assay Mouse Lymphcanal 1254 mg/kg (males, i.p.) 1001 mg/kg (females, i.p. ), - (Confirmed). - Rabbit Eye Rabbit Eye (low dose)', CardYavasc. /Respir. 5rDay Range-Finder Enzyme Induction Immmosuppression Severely Irritating Minimally Irritating -(!Insoluble accord:ing to ir+enxx of 7/2/82)1 MTD = 2500 nxg/kg (males) MTD = 11250' mg/kg (females) : O Q SOURCE: Crompton-Knaales; Folarane; Arcana Resources.

COMPOUND: Oil of Clary Sage ('B11) LD5© 1262 mg/kg ('i.p.)i Ame s As s ay - Mouse Lymphoma Cardiovasa./Respir. 5-Day Range-Finder Enzyme Induction Immunosuppression SOURCE: Ungerer COMBCUND:6-1rTeth,y]JBenz~opy~rone(B12) FsmA a6-49. LDa, > 700, mg/kg (p.o.) 14-Day Subacute Pend!ing Anes Assay - (Contracted) Mouse Lymphoma - Rabbit Eye - Cardiovasc./Respir. - (Insoluble according to memo of 10/I9/'8'3). 5-Day Range-Finder MTD = 750~mg/kg (males), MTD, = 375 mg/kg (females) Enzyme Induction 0 Immunosuppression SOURCE: Givaudan; Norda ,% M

C ONF ID ENT IAL , COMPOUND~: Lor~'illliard' C'onc~entrate~ 2491*' (B~13)~ 14-D'ay Subacute Ames Assay Mouse Lymphoma >5000 mg/kg,(ip)i - (Confirmed). s ~ Card!iovasc./Respir. - 5-Day Range-Finder Enzyme Induction MTD = 5000 mg/kg, - Immunosuppression, - *Consists of B27, B75', B43, B3, B29, B63, and B12 SOURCE: Lorrililardl Flavor COMPOUND: ImitationlChocolate P-4482 (B14) LD50 Ames Assay Mouse Lymphomai Cardiovasc./'Respir.. 5-Day Range-Finder Enzyme Induction Immunosuppression SOURCE: Kohnstamm

COMPOUri]D': Ctiocoiate 13169 (B15) ID50~ Ames Assay hbuse LympTcna Rabbit Eye Rabbit Eye (Iowdose) Cardn.ovasc./Respir. 5-Day Range-Finder Enzyme Induction IrRminosuppression SOURCEc Naarden ]D: Creme de Menthe Concentrate F-2475 (B1O LD50 ' ATres Assay Mbuse Lymphana. Rabbit Eye Rabbit Eye (low dbse)' Cardiovasc./ltespir. 5-Day Range-Finder. Enzyme Induction IPmnxnosuppression S0[7RCEs Givaudan.

COMPOUIVD: *Cocoai#135'3'4110 (B17) LD50 6184 mg/kg (i.p.) Ames Assay - (1977) ,'' Mouse Lymphoma Rabbit Eye + Rabbit Eye (,low dose) Cardiovasc./'Respir. - > 5-Day Range-Finder ILITD' = 5000 mg/kg, Enzyme Induction - Immunosuppression - *Testing stopped 4/23'/'82 - no longer in product SOURCE: International Flavors & Fragrances COMPOUND: (,B18'IS A DUPLICATE OF B9) LD50 Ames Assay Mouse Lymphoma Rabbit Eye Rabbit Eye (low dose). Cardiovasc./kespi'r.. 5-Day Rangp-Finder Enzyme Induction Immuno.suppression SOURCE: %. :

COMPOUND: Oi'L of Clary Sage (B1I9), LD50 Ames Assay Mouse Lymphoma. Rabbit Eye Rabbit Eye (low dose) Card~iovasc./'Respir. 5-Day Range-F:inder Enzyme Indiacti'on Immunosuppression SOURCE: Tobacco Technology COl41PQU'ND': Cinnamon Bark Oil RY22911 (,B20') LD50 Ames Assay NPouse Lymphoma Rabbit Eye - Rabbit Eye (,low dose) Cardiovasc./Respiir.. 5-Day Range-FYnd6r Enzyme llnduction~ Immunosuppression FE01 A,'2q 1 A- SOURCE: N'aardeni

COMPOUND': Artificial Cburmarin 13568640 (B21) LD50. Ames Assay Mouse Lymphoma Rabbit Eye Rabbit Eye~ (low d'ose) . Cardiovasc.%Aespir. - 5-Day Range-Finder Enzyme I[nduction Immunosuppression SOURCE: International Flavors & Fragrance& C6MROUND:(B22IS A DUPLICATE OF B10), . . •~. LD50 Ames Assay Mouse Lymphoma Rabbit Eye Rabbit Eye (low dose) Cardiovasc.['Respir. 5-Day Range-Find'er Enzyme Induction Immunosuppression SOURCE:

COMPOUND: Artificial Date F-5715 (B23) LD5© 2422 mg/kg (i.p.) 14-Day Subacute Pending, Ames Assay - (Confirmed)i M'ouse Lymphoma *Rabbit Eye (low dose) Minimally Irritating Cardiovasc./Respir. - 5-Day Range-Finder MTD' = 3750 mg/kg, (males). MTD' > 5000' mg/kg, (females). EnzymeInduction+ (mice only) Immunosuppression - *Test only at low dose since pH = 2.79' SOURCE: F~i'rmenich COr:FZiDENTIAL COMPOUND~: Oil of Dillweed Extract (B24) 14-Day Subacute Pending LD50 1150' mg/kg (i.p.). Ame&Assay - (Confirmed) Mouse Lymphoma Rabbit Eye Minimally Irritating, Cardiovasc./'Respir. Insoluble 5-Day Range-Finder MTD >= 5000 mg/kg (males)'. MTD:a 3125 mg/kg (females) Enzyme Induction 0 l;. Immunosuppression - SOURCE: Fritzsche O OI 'A tJ' hJ'

COIKP©UND: (B25. IS A DUBLICAZIE OF B3) LDS0 Ames Assay Mouse Lymplioma Cardiovasc.,/,Respir. 5-Day Range-Finder Enzyme Induction Immunosuppression SOURCE: COMPOUND: Lorililard! Concentrate 2911* (B26)' CONFIDENTIAL 14-Day Subacute 285:4 mg/kg (males and females, i.p.) Ames Assay - (Confirmed) Mouse Lymphoma Rabbit Eye Severely Irritating Cardiovasc./Respir. - 5-Day Range-Finder MTD' = 3750 mg/kg,(males). MTD > 5000mg/'kg, (females) Enayme Induction - Immunosuppression - *Composed of B9, B'1U, and B39, SOURCE: Lorillard Flavor O 0 o. ~ ~ N N Ob

COMPOUND: Chocolate, Artificial (B27). LD50, 2147 mg/kg (i.p~.)' 14-Day Subacute (ip) <1540 mg/kg (liver pathology noted')' 14-Day Subacute (oraL) >5000:mg/kg Ames Assay - (Oonfirmed)M'ouse Lymphoma - Rabbit Eye + Rabbit Eye (low dose)' Minimally Irritating, Cardiovasc./Respir. - 5-Day Range-Finder MTD > = 5000 mg/kg, Enzyme Induction 0 (females), - (males) Immunosuppression - SOURCE: Firmenich COMPOUND: Glycerine 9'9'.5%, USP -#7 Flavor (B28)' LD'50 tlines~~ As~~say~ - (1970 PMouse Lymphoma Card'iovasc.,/Respi:r., 5-Day Range-Find'er Enzyme Induction ImmunosupPres~~s~~ion SOURCE: Proctor & Gamble FEMA 9.5a 9 i

CONFIDENTIAL COMPOUND: Heliotropin, Extra ($2'9). Fc.wlA aq 1 I' LDSa 9'40 mg/kg (maLes) (i.p. ). 906 mg/kg (females) (i.p. ) 14-D'ay Subacute 1055 mg/kg (combined sex, ip) Ames Assay - (Co:nf irmed) Mouse Lymphoma - Rabbit Eye - Cardiovasc./Respir. - 5-Day Range-Finder MTD = 137'5 mg/kg (males)'. MTD = 750 mg/kg (fema]Jes). Enzyme Induction 0 Immunosuppressi:on SOURCE: Nordai COMPOUND: Lovage Oil (B30) F511174 01105;1 14-Day Subacute 374 mg/kg,(males, i.pi.) 465 mg/kg (females, i.p.) Ames Assay - (Confirmed). Mouse Lymphoma Cardiovasc./$'espi'r. Insoluble Multi-Dose Range-Finder MTD = 313 mg/kg (males) MTD' = 375 mg/kg (females). Enzyme Induction Pending, Immunosuppression Pending, SOURCE: Polarome ~ y

COMPOUND: Licorice, Extract - #1001 Flavor (B31)~ LD0 > 10'00 mg/kg (p.o.) 14-Day Subacute 3349 mg/kg (males, ip) 2299 mg/kg, (f emales , ip)' CONFIDENTIAL ren.4 a6A? Ames Assay - (Contracted) Mouse' Lymphoma +(with&withoutActivatiionY Mouse Lymphoma (Rerun) Pending Chromosomal Aberration + (;With Activation). Rabbit Eye Mildly Irritati'ng, Rabbit Eye (low dbse) Cardiowa!sc. /Respir., * 5-Day Range-Finder MTD = 51000'mg/kg. Enzyme Induction 0~ Immunosuppressi'on - * Not retested'since usage level x 100' exceedls tested dose SOURCE: MacAndirews & Forbes COMPOUND: Licorice, Artificial (50.691/A) (B32)' 1041 mg/kg (i.p.), LD SO 14-Day Subacute. Ames Assay Mouse Lymphoma Mouse Lymphoma (R'erun)i Rabbit Eye Rabbit Eye (low dbse) Cardiovasc./Respir. 5-Day Range-Finder Enzyme Induction. Immunosuppressilon SOURCE: Firmenich 637 mg/kg,(males, ip). 679~~ mg/kg ('~females,~ i'p), - (Cbnf irmed) + (with & without Activation) Pending Severely Irritating, Minimally Irritating, 0 (yCO) (Test #1) 0~ (;+TV~)~ (Test ~~ #2) , Insoluble according to memo of 7'/2/8'2 and 10/'11/83' MTD,= 1375 mg/kg y

COMPOUND: (B33 IS' A DUPLICATE OF B31)'. L.D50 Ames Assay 'Mouse .Lymp}homa R'abbit Eye Rabbit Eye (low dose)'. Cardiovasc,/Respir.5-Day Range-Finder Enzyme Induction Ihnmunosuppression SOURCE: COMPOUND: Maltol (B3'4). LD50 . Fr=M,A A'~54 Ames Assay Mouse Lymphoma Rabbit Eye Rabbit Eye (low dose)' Cardiovasc./Respiir. 5-Day Range-Finder Enzyme Induction Immunosuppressiion 11 SOURCE: Naarden

COMPOUND: Menthol,, BraaiLian (USP) (B35)'. (NOTESTING) LDQ > 1000 mg[kg (p.o.). Ames Assay Mouse Lymphoma Rabbit Eye Severely Irritating Rabbit Eye (low dose)~ CArdiovasc./Respir.- 5-Day Range-Finder MTD=1'~250 mg/kg Etixyme Induction + Immunosuppression - APPROVED BRANDS: Braswey, Bwddha;, Brasmenthol APPROVED SOURCES: I.R. Boody; J. Manheimer; George Uhe Co.; Biddle-Sawyer COMPOUND': 1-Menthol, Synthetic (B36)'. (NO~ TESTING) LD50 Ames Assay - Mouse:Lymphoma Rabbit Eye - Rabbit Eye (low dose) Cardiovasc./Respir. 5-Day Range-Finder Enzyme Indhcti'on Immunosuppression SOURCE: Takasago; Haarmann & Reimer . P

C0MP0UND: Artificial Marshmallow 59.360/A (B37) 14-Day Subacute Pending Ames Assay - (',Confirmed)' Mouse Lymphoma Rabbit Eye Moderately Irritating Cardiovasc./Respir.. 5-Day Range-Finder MTD'= 3750 mg/kg (males) MTD' = 3125 mg/kg, (females) Enzyme Induction Immunosuppression - SOURCE: Firmenich C0NfP0UtQD: Artificial Nutmeg (B38) LD50 T736 mgJkg (,i.p.)i Ames Assay - Mouse Lymphoma Cardiovasc. /'Respd:r . 5-Day Range-Finder Enzyme Induction. Immunosuppression C OriT'FID ENT IAL SOURCE: Ungerer. ~ y

COMPOUND: Oil, Nutmeg, East India Select (B39) LDg0 1593 mg/kg (i.p.) 14-Day Subacute 2743 mg/kg (males, ip) 3D0'1 mg/kg (femalles, ip) Ames Assay - (Conf irmed) Mouse Lymphoma - Chromosomal Aberration - Rabbit Eye Non-irritant Cardiovasc.,/Respir., - 5-Day Range-Finder MTD = 31i251mg/1cg (males), MTD = 17501 mg/kg, (',females). Enzyme Induction + Immunosuppression - FF=h,A a7q3 SOURCE: J. Manheimer, Flavor Resources COMPOUND,: New England!Rum Flavor SA 90562 (B40) *(replaced'by B109) LD , S0 Ames Assay Mouse Lymphoma Cardiovasc./Respir. 5-Day Range-Finder EnzymeInd'uction Imnmunosuppressi:on SOURCE: Naarden *testing stopped16[8'2 ` O. O. .~ W ~'

COI4'IPOUND': (B41 IS A DUPLICATE OF B3'9). LD50 Ames Assay Mouse Lymphoma. Rabbit Eye Rabbit Eye (low d'ose) Cardiovasc./Respir. 5-Day Range-Finder Einzyme Induction Immunosuppression S'OURCE: COMPOUND: Phenylacetic Acid (B42) FEMfl a8~8' LD50 98' mgfkg' (i'p:.) 14-Day Subacute 340 mg/ltg, (males,,ip) 398' mg,/kg (females, ip). Ames Assay - (Conf irmed). Mouse Lymphoma - Rabbit Eye: Extremely Irritating Rabbit Eye (low.dose) Non-irritant Cardiovasc./Respir. - 5-Day Range-Findler KTD' = 3750 mg/'kg, (males) MTD = 1750 mg/kg, (females). Enzyme Induction, Immunosuppression, SOURCE': K&K Labs

CONFIDENTIAL COMPOUND: Propylene Glycol - USP (B43): (NOTESTING). LD50 Ames Assay Mouse Lymphoma Cardiovasc./Respir. 5-D'ayRange-Finder Enzyme Induction Immunosuppression FEl"1A a'Q L40 SOURCE': Arco Chemical Co.; Oxirane; D'ow;, Union Carbide; Industrial Chemical Co.;,Devoni COMPOUND: St. .John"s Bread, Roasted (B44) LDO, > 10'000 mg/kg (p'. o. )' 14-Day Subacute > 1260 mg/kg (i.p.) Ames Assay - (Conf irmed), Mouse Lymphoma - Rabbit Eye • Mildly Irritating Rabbit Eye (low dose) * Cardiovasc./Respir. - > 5-Day Range-Finder MTD = 5000 mg/kg Enzyme Inducti'on - Immunosuppression - *Not retested since usage level x 1100' exceeds tested dbse SOURCE: J. Brampton; Hugo Internat'ional;, M.F. Neal. y

COMPOUND: Raisin Concentrate (B45). LDa > 9000 mg/kg,(i.p.) 14-Day Subacute Pending Ame&Assay - (,Confirmed)l Mouse Lymphoma - Rabbit Eye Minimally Irritating Rabbit Eye~ (liow dose)' * Cardtiiouasc. /Aespir. - 5-Day Range-Finder MTD = 5000 mg['kg, Enzyme Ind'uction - Immunosuppressi'on - *Not retested'since usage level x 100 exceeds testedidose SO.URCE: J. Brampton; Ilenrietta Rancho;, Massey & Fair. COMPOUND: St. Johni"s Bread (B46)' LD50. Ame&Assay - ('1976). Mouse.Lymphoma Rabbit Eye 5-Day Range-Finder Enzyme Inductioni Immunosuppression SOURCE: J. Brampton; M. F. Neal :11

COMPOUNDi: *Rum - Special Denatured (150'Proof) ('B47) LD50 Ames Assay - (19'8'0). Mouse Lymphoma Rabbit Eye Rabbit Eye (low dose) Cardiovasc./Respir. 5-Day Range-Finder Enzyme Induction Immunosuppression *Testing,stopped 4/23/82 - no longer in product SOURCE: Felton & Sons COMPOUND: SAG 730 Silicone Antifoam ('B48)' LD© > 1&,000 mg/ltg, (i.p,j Ames Assay - (Confirmed): Mouse Lymphoma - Rabbit Eye Mildly Irritating Rabbit Eye (low dose) Minimally lirritating. Cardiovasc. /Respir. i C0, + HR Cardiovasc./'Respir. (retest) - 5-Day Range-Finder MLD = 5000 mg/kg Enzyme Induction Immunosuppression~ SOU'RCE': Union Carbide i:

COMPOUND: Syrup, Brown Invert ($49')' LD5'0. Ames Assay Mbuse Lymphoma Card'iovasc. ['Respir. 5-Day Range-Finder. Enzyme Induction - (1976) , CCONFIDENTIAL Immunosuppression SOURCE: Godchaux-Henderson; Savannah Sugar COMP031ND: Brown Sugar 301331T (B50). LD50 14-Day Subacute Ames Assay Mouse Lymphoma Mouse Lymphoma (Rerun), Chromosomal Aberrationi Rabbit Eye Rabbit Eye (low dose): Cardiovasc./Respir. 5-Day Range-Fi,nder Enzyme Induction Iffiunosuppression. SOURCE: Firmenich 622 mg/kg, (i•p«) Pending - (Confirmed) + (With and Without Activation)! Pending Pending Extremely Irritating Minimally Irritating MTD = 5000 mg/kg (males)'. MTD1= 3IIl25' mg/kg (females)' - M s

COMPOUND: Corn S~rup - Clearsweet (B'5T). LD501 Ames Assay: - (1976) Mouse Lymphoma Rabbit Eye Rabbit Eye (low dose)l C'ardiowasc./'Respir. 5-Day Range-Finder Enzyme Induction! Immunosuppression~ SOURCE: Cargill; Grain Processing; CPC International COMPOUND: Natural and Imitation Spearmint 57.327'/A (B52) LD50 Ames Assay - (1980) Mouse Lymphoma Rabbit Eye Rabbit Eye (low dose) Card'iovasc./Respir. 5-Day Range-Finder Enzyme Induction. Immunosuppression SOURCE: Firmenich

COMPOUNIDI: (B53 IS A DUPLICATE' OF' B52) LD 50 Ames Assay Mouse:Lymphoma Rabbit Eye Rabbit Eye (low dose), Cardiovasc./Respir. 5-Day Range-Finder Enzyme Inducti'on. Immunosuppression SOURCE: COMPOUND: Artificial Stabilized Spearmint 17418' s 54). LD50 Ames Assay ,'' - (1980) Mouse Lymphoma Rabbit Eye Rabbit Eye (low dbse)~ C'ardiovasc.,/'Respir. 5-Day Range-Finder Enzyme Induction. Immunosuppression -; SOURCE: Fries & Fries 4

COMPO[JND'.: Imitation Tbbacco13011.829 (B5S)'. LD50 1701 mg/kg (i.p.) Ames~Assay~ - (~,1978')i Mouse LymphomaRabbit Eye Rabbit Eye (',1ow dose) Cardiovasc./'Respir. 51-Day Range-Finder Enzyme Induction Immunosuppression SOURCE: Firmenich COMPOUND: Imitation Tobacco 302'.836/S (B56) LD50 2032 mg/kg AmesiAssay - Mouse Lymphoma Rabbit Eye Rabbit Eye (low dose) Cardiovasc./'Respir. 51-Day Range-Finder Enzyme Induction Immunosuppression SOURCE: Firmenich 41

COMPOUTv'D.: Tabacarome F-9115 (B57) LD50 9000 mg/kg (i.p.) Ames Assay - (,19'78). M'ouse Lymphoma Rabbit Eye Rabbit Eye (low dbse), Cardiovasc./Respir.. 5-Day Range-Finder Enzyme Induction Immunosuppression :v SOURCE: Givaudan, COMPOUND: Tobacco 52'.647 (B58)' LD50 2~4'05;mg/,'ltg (i. p. ) Ames Assay - (1978) Mouse Lymphoma . Rabbit Eye Rabbit Eye (low d'ose)' Cardiovasc.%Risspir.5-Day Range-Finder Enzyme Induction Immunosuppression . SOURCE: Firmenich

COV2OUND: TobacmFlavor 303.615['S (B59) LD50 Ames Assay - (1980) Mouse Lymphoma Cardiovasc./Respir. 5-Day Range-Find'er Etizyme Induction Immunosuppression SOURCE: F~irmenich COMPOUND: Tobacco Flavor 53.45ll/S (',B60)~ C IONFIDENT IAI: 14-Day Subacute P'ending, Ames Assay - (1982) ,Mouse Lymphomai + (with & without Activation) Cardiovasc./Respiir. - 5-Day Range-Finder MTD,> 5000 mg/kg Enzyme Induction ++ Immunosuppression - SOURCE': F'irmenich, ,r. 41

COMPOUND': Tobacco Flavor 2Q-03654 (B6T). I.D1 5O Ames Assay ', - (1980) NMouse Lymphoma Rabbit Eye Rabbit Eye (low dose) Cardiovasc./'Respir. 5-Day Range-Finder Enzyme Induction Immunosuppression SOURCE: Naarden C0MPOUND': Uncourvan 7450 (B62) LD'S0 Ames Assay - (1980) Mouse Lymphoma Rabbit Eye Rabbit Eye (low dose) Cardio:vasc,/kespir. 5-Day Range-Finder Enzyme Induction ImmunosuppressiLon SOURCE: Ungerer -

COMPOUND: Vanillin - USP, Lignin (B63) LD0>900' mg/kg (p. 14-Day Subacute Pending, Ames Assay -(Contracted) Mouse Lymphoma - Rabbit Eye + Rabbit Eye (low dose) Moderately Irritating Cardiovasc./'Respir. - 5-Day Range-Finder MTD = 500'mg/kg Enzyme I'nduction Fp-m~,9i 31,07 Immunosuppression - SOURCE: McKesson; Zinc & Triest; Bush Boake Allen COMPOUND: (B64 IS A DUPLI'CATE OF B63) LD50,. Ames Assay Mouse Lymphoma Rabbit Eye. Rabbit Eye (low dose) Cardiiovasc./Respir. 5-Day Rangp-Fiinder Enzyme Induction Immunosuppress3:on SOURCE: -

COMPOUND: Vanilla Bean P-770 ('B65)i CONFIDENTIAL FEr)h 3r'o S LD50, 1552' mg'/kg, (i.p.) 14-Day Subacute 1'632'mg/kg (males,,i.p.)i 1405 mg/kg (',females, ii.p.)' Ames Assay - (,Confirmed), ~ Mouse Lymphomal + (with and without Activation)' Mouse Lymphoma (Rerun) Pending Rabbit Eye + ** Rabbit Eye (low dose) Cardi'ovasc~. /Respir. - 5-Day Range-Finder MTD = 2500 mg['kg. Enzyme Induction - Immunosuppression - * weak + ** Not retested since usage level x D00 exceeds tested dose SOURCE: Kohnstamm C0IWIPOUND': YMSM 2980 (B66). LD50 . Ames Assay - (1i981) Mouse Lymphoma. Cardiovasc./Respir. 5-Day Range-Finder Enzyme Induction Immunos.uppression SOURCE: Tobacco Technology GD sr

COMPOUND: *Tobacco Flavor BB-70'TC (B67)' (Formulation Change - New #B122.)'. LD50 4564 mg/kg (i.pj Ames Assay - (1977') Mouse Lymphoma: Rabbit Eye Moderately Irritating Rabbit Eye (1ow dose)' Cardiovasc./'Respir. - > 5-Day Range-Finder MTD = 5000' mg/'kg, Enzyme Induction 0 ('females) , - (maIles)~ Immunosuppression *Testing, stoppedi 4/16'[82. SOURCE: Tobacco Technology COMPOUND: (B68 ISI A DUPLICATE OF' B19) LDg0' Ames Assay1Wlouse Lymphoma Rabbit Eye ,. Rabbit Eye (low d'ose)' Cardiovasc./Respir. 5-Day Range-Finder Enzyme Induction Iimmunosuppress3'~:on SOURCE: _~v

CCNTOUND: Carob Bean Concentrate 340'-270'0 (B69) LDi0, > 10,000 mg/kg (i.p.) 14-Day Subacute Pending Ames Assay - ('Confirmed) Mouse Lymphoma. Rabbit Eye Minimally Irritating Rabbit Eye (',llow dose) Non-Irritant Cardiovasc./Respir. - > 5-Day Range-Finder MTD = 5000 mg/kg Enzyme Induction IIIanunosuppression - SOURCE: Givaudan COMPOUND: Artificial Tobacco Flavor 52.648 (B70)'. LD50' Ames Assay - (1980) Mbuse Lymphoma Cardiovasc./Respir. 5-Day Range-Finder Enzyme Inducti'on 7lmmunosuppression. SOURCE: Firmenich

COMPOUND: Anethole, FCC, Redistilled (B71), 14-Day Subacute Ames Assay NPouse Lymphoma Rabbit Eye Cardiovasc./'Respir. 5-Day Range-Finder Pending - (ConfirmeO + (With ActiivatioO Minimally Irritating Insoluble MTD = 1750 mg/kg (males) MTD = 3125 mg/kg (females)I Enzyme Induction -* Immunosuppressson - *Toxic to male rats (liver): SOURCE: Fritzsche CONFIDENTIAL F6mA, .2-08''G C0IKPOUND: Oil, Orange, Sweet Sesquiterpeneless, 6X ' (B72) y FEti A a, 8'.2'a, ~. LDS0 14-Dayr Subacute Ames Assay lyTouse Lymphoma Mouse Lymphoma (Rerun) Rabbit Eye Cardiovasc./Raspir. 5-Day Range-Finder Enzyme Induction I5001mg/kg (',i.p.) 1131' mg/kg (males, ip), 1110' mg/kg (females, ip) - (Confirmed). + (with & without Activation) Pending -(,Insoluble according to memo of 1/'12/'83)' MTD = 5000 mg[kg 0 - Immunosuppression - (z) 4 SOURCE: Fritzsche C 0I

COMPOUND: Valerian Fluid Extract (B73')'* CONFIDENTIAL FEMA 3019 14-Day Subacute Pending, LD50 4683' mg/kg (i. p~, ) Ames Assay - (Confirmed). Mouse Lymphoma, + (with & without Activation)'. Rabbit Eye Severely Irritating, Rabbit Eye (low dbse) ** Cardiovasc./Resp3:r., - > 5-Day Range-Finder MTD = 5000,mg/kg Enzyme Induction - Immunosuppression - *Testing,stopped 6/14/83 - no longer in product - reactivated'3/6/84 **Not retestedisince usage level x 100 exceeds tested!dose SOURCE: Manheimer COMPOUND: Chocolate #2844 (B74)* LD'50 5130 mg/kg, (i.p.) Ames Assay - (1y78) Mouse Lymphoma + (with & without Activation) Rabbit Eye Moderately:Irritating Rabbit Eye (low dose) Minimally Irritating Cardiovasc./Respir. _** ~ 5-Day Range-Finder 14irD = 5000 mg/kg Enzyme Ihduction - Immunosuppression - *Testing,stopped 6/14/83 - no longer in product - reactivated 3/6/84 **Decrease.in B.P. at high dose SOURCE: Kohnstamm: _f

COMPOUND': Mapleine (B7'5). LD0 > 10368' mg/kg (i.p.). 14-Day Subacute F+end!ing Ames Assay - (Confirmed)i Mouse Lymphoma - Rabbit Eye - Rabbit Eye (low dose) Card'iovasc. /Respir. - 5-Day Range-Finder MTD > = 5000 mg/kg Enzyme I'nducti'on 0 Immunosuppression - SOURCE: Crescent Manufacturing COMPOUND: *Casing #0/'132622 (B76) (Formulation Change - new #B110) LDQ Ames Assay > 10368 mg/kg',(i.p.) - (1980) Mouse Lymphoma Rabbit Eye - Rabbit Eye (low dose) Cardiovasc./Respir. 5-Day Rangp-Finder Enzyme Induction MTD >= 5000' mgfkg 0 (,females)~, - (males). W~ . Iimmunosuppression - *Testing stopped11['26/82' SOURCE: Dragoco O C C ~ ~ C1T W

COi,TOUrID: Tobacarome Flavor 9346 (B77). 14-Day Subacute }5000! mg/'kg, (i.p.) Ames Assay - (Confirmed) Mouse Lymphoma Rabbit Eye Moderately Irritating Cardiovasc./Respir. - 5-Day Range-Find'er MTD } ' = 5000 mg/kg Enzyme Induction, Immunosuppression: SOURCE': Givaudan COMPOUND: Currant, Artificial Red (',B78). LD50. Ames Assay - (,1976)'1 Mbuse Lymphomai Cardiovasc./'Respir. 5-Day Range-FYnder. Enzyme Induction Immunosuppression SOURCE: Firmenich i.

COMPOUND: Walnut, Artificial Green (B79) LD50 Ames Assay - ('ll982)~ Mouse Lymphoaa Rabbit Eye Rabbit Eye (low dose) Cardi'ovasc./Respir. 5-Day Range-Finder Enzyme Induction Immunosuppression SOURCE': Firmenich COrifP0UNTD: (B80' IS' A DUPLICATE OF B32)' LD50 Ames Assay Mouse Lymphoma Rabbit Eye Rabbit Eye (low dose): Card'iovasc. /'Respir. 5-Day Range-Find'er Enzyme Induction Immunosuppression .-, SOt7RCE :

C0MP0 UND:' *Tob~~acco~~ F'lavox,52'~.6'44 ~ (B81) (~Formulation Ch~ange~ - 1Vew~ #'B111) LD50 1200 mg/'kg (i.p.). Ames Assay - (1977). Mouse Lymphoma. Rabbit Eye Extremely Irritating Rabbit Eye (low dose) - Cardiovasc./Respir. 5-Day Range-Finder MTD = 2500'mg/1tg Enzyme Induction 0' ][mmunosuppression - *Testing stoppedi ll/26['82 SOURCE: Firmenichi COMPOUND: (B82 IS A DUPLICATE OF B27) LDS0 Ames Assay Mouse Lymphoma Rabbit Eye . Rabbit Eye (low dose). Cardiouasc./'Respir. 5-Day Range-Finder Enzyme Induction Iimmunosuppre s si:on SOURCE:

CONFIDENTIAL, COMPOUND: Artificial Tobacco 53'.,40'1 (B83) LD50 2072 mg/kg (,i.p.) 14-Day Subacute Ames Assay F'ending - (,Confirmed)~ r ~ Mouse Lymphoma Mouse Lymph!oma (Tt'erun). Rabbit Eye Cardiovasc.[Respir.. 5-Day Range-Finder Enzyme Induction Immunosuppression + (Without Activation) Pending Moderately Irritating MTD = 1375 mg/kg - SOURCE: Firmenich COMPOUND: Tobacco 57.56:1 (B84) LD0 14-Day Subacute Ames Assay . Mouse Lymphoma Rabbit Eye R'abbit Eye (low dose)' Cardiovasc./Respir. 5-Day Range-Finder > 500&mg/kg (i.p.)i > 5000' mg/kg (i.p.), - (Confirmed)'. + (With Activation). Minimally Irritating, Practically Non-Irritating MTD = 5000' mg/kg ; Ehzyme Induction Immunosuppression SOURCE: Firmenich. O O O' C!1 'j

COMPOUND: Artificial Chocolate 1924 (B85) (Formulation Change - New #B112') LD50 Ames Assay Mouse Lymphoma. Rabbit Eye Cardiovasc.[Respir. 2900 mg/'kg (i.p.) - (1978). S'evereliy Irritating, 5-Day Range-Findler MTD = 1375 mg,/kg, Enzyme Induc¢ion Immunosuppressd:on - SOURCE: William Bell COMPO1fJND:Cherry„ Artificial 0D-39579' (B86) LD50. Ames Assay - (1981) Mouse Lymphoma Cardiovasc. /Respi'r.5-Day Range-Finder Enzyme Induction. Immunosuppress3'on SOURCE: Naarden i, _f, . Go

COMPOiTND: Chocolate, Artificial (7M02'619)'. (B87) LD0 > 1000'mg/kg (i.p.)~ 14-Day Subacute > 50001mg,/kg (ip)i Ames Assay - (C'onfirmed)~ NPouse Lymphoma - Rabbit Eye Minimally Irritating * Rabbit Eye (liow dose), Cardiovasc.['Respir. - 5-Day Range-Finder ILITD'> = 5000 mg/kg. Enzyme Ind{uction 0. 7lmmunosuppression, - *Not retested since usage level x 100 exceeds tested dose SOIJRCE:Naard'en, COMP'OUND. *Walnut CD79429 (B88) (FormulationiChange - New #B113)' LD 0' > 8640 mg/kg (i.p.)'. Ames Assay - (1977) Mouse Lymphoma Cardiovasc./Respir. 5-Day Range-Finder MTD > = 5000 mg/kg Enzyme Ind'uction. Immunosuppression *Testing stopped 1/26/82 4.1 SOURCE: Naarden 0 - O C . N C8

COMPOUND: Cocoa, Artificial (~S'0-01~100) (B89): . LD50' Ames Assay~~ -~ (~19~7'61)'~ Mbuse Lymphoma Cardiowasc./:Respir. 5-Day Range-Finder Enzyme Ind'uction • Immunosuppression. SDURCE: Naarden COMPOUND: Raisin~F~lavor 71-05999 (B90) (',replaced by B'I67') LD50 Ames Assay - (1982') Mouse Lymphoma Cardl:ouasc.fRespir. - > Multi-Dose Range-Finder MTD = 5000 mg/kg (rats) > Mu11ti-Dose Range-Finder MTD = 2500 mg/kg (mice) ' Enzyme Induction 0* Immunosuppression **' *some toxicity to mice and~ rats. **study aborted because of toxicity to mice at 2500 mg/kg SOURCE: Naarden .:

COMPOUND: *Deer Tongue, Powder, #10 Flavor (B911) (Formulation Change - New #B'11'4) LD50 Ames Assay - (19'76). Mouse I.ymphoma Rabbit Eye Moderately Irritating, Cardiovasc./Respir. 5-Day Range-Finder MTD ~ = 5000 mg/kg Enzyme Induction Iimmunosuppression *Testing, stoppe&1[2j6/82'. SOURCE: M.F. Neal; Suwannee COMPOUND: Sage, Powder - Dalmation (B92) 17EMA 3©©, D LD0 > 1000 mg/kg (p.o'.) 14-Day Subacute Pend'ing, Ames Assay - *' Mouse Lymphoma - Rabbit Eye Severely Irritating Rabbit Eye (low dose) ** Cardi:ovasc./Respir. - 5-Day Range-Find'er t3TD > ' = 5000 mg/kg Enzyme Imdhiction - Immunosuppression - *Can't confirm by GLP'Ames because of insolubility **Not retestedisince usage level x 100 exceeds tested dose. SOURCE: J!. Brampton; M.F. Neal; McCornick sr

COMPOUND~: Nutmeg, Powder - East Indiani (B93) LDiO, > 1000 mg/kg (P.o. ). 14-Day Subacute > 5000 mg/kg (p.o.) Ames Assay -*' Mouse Lymphoma Rabbit Eye Mildly Irritating Cardiovasc. /ltespir. - ~ 5-Day Range-Finder MTD = 5000 mg/kg, Enzyme Induction 0~ Immunosuppression - *Can't confirm by GLP Ames because of insol!ubility SOURCE: J. Brampton;, M.F. Neal COMPOUND: Prune Concentrate (B94) LD'0 > 1000 mg/kg (i.p'.). 14-Day Subacute > 500i0' mg/kg (p.o.). Ames Assay - (Confirmed')~ Mouse Lymphoma + (with Activation)~ Mouse Lymphoma (Rerun)'~ + (with Activation) Chromosomal Aberratiom P'ending, Rabbit Eye Minimally Irritating Rabbib Eye (low dose) * Cardiovasc./'Respir. - } 5-Day Range-Find'er MTD' = 5000 mg/kg Enayme,Induction- Immunosuppressioni - *Not retested since usage level x 100 exceeds SOURCE: J!., Brampton; Henrietta Rancho. CC)1`;FID'ENTZAI: FE/qA: a 7Ro . testedd dose., -P

COTU''OtJND: Balsam Peru (B95) w'i'Ai aH6 LD' 0 > 1T000' mg/kg' (,i.pi.) 14-Day Subacute Pending, Ames Assay - (Confirmed) Mouse Lymphoma Rabbit Eye Moderately Irritating, Rabbit Eye (low dose) Mildly Irritating Cardiovasc./Respir. -(Insoluble according,to memo of 1/12'/'83). 5-Day Range-Finder' MTD- 3750 mg/kg (males) MTD > 5000 mg/kg (males). Enzyme~ Induction 0'~ Immunosuppression SOURCE: J. Brampton; Crompton-Knowles; Polarome's D-600 C0NiP0U1aD: Styrax - USP (B9'6)' LD0 ll4rDay Subacute FEM Ai 8 Q 3.4 > 1000'mg/kg, P end i:ng i., Ames Assay - (Confirmed). Mouse Lymphoma Rabbit Eye Minimally Irritating Rabbit Eye ('low dose) Minimally Irritating Cardiovasc./~Respir. Insoluble: 5-Day Range-Finder MTD > = 5000'mg/kg Enzyme Induction 0' ]Immunosuppression S(}URCE'.: J. Brampton; Berjie; Polarome; Manheimer's #303250

COMP0UND: Ammonium Phosphate, Dibasic (B9'7) (No Testing - See SCOGS Report) LD50~ Ame~s~,Assay - (1982) Mouse Lymphoma Rabbit Eye Rabbit Eye (low dose)' Cardiovasc./Respir. 5-Day Range-Finder Enzyme Induction Immunosuppressiom SOURCE: Worth; Stauffer; Industrial; McKesson CQMPOUND: Citric Acid,,Anhydrous (B98) (No Testing - See SCOGS Report) LD50 Ames Assay - (198'1). Mouse Lymphoma Rabbit Eye Rabbit Eye (low dose) Card~iovasc./Respir. 5-Day Range-Finder Enzyme Indtiction Immunosuppression 0 SOURCE: Fisher S'cientific

COMPOUND: Myristic Acid (B'99') CONFIDENTIAL F&MA a76* 14-Day Subacute Pending Ames Assay -(Contracted) Mouse Lymphoma - Rabbit Eye Moderately Irritating Rabbit Eye (low dose), * Cardiovasc./Respir. - 5-Day Range-Finder MTD~> = 5000' mg/'kg Enzyme Induction - Immunosuppression - *Not retested since usage level x 100 exceeds tested dose SOURCE: Naarden (RY'27640).; Eastman Organic Chemicals COMPOUND: Peppermint Oil N02923' (8100) 14-Day Subacute 785 mg/kg (males:, ip.)~ 711 mg,/kg, (females, ip) Ames Assay - (Confirmed) Mouse Lymphoma - Rabbit Eye Moderately Irritating Cardiovasc./Resp2r. - 5-Day Range-Finder MTD = 1750' mg/kg. Enzyme Induction Immunosuppression SOURCE: Naarden + Fe mi a? 4 9 _p

C02KPOUND: Lemon Ofil, Naardenized 06069 (B101)* LD50 Ames Assay Mouse Lymphoma. Rabbit Eye Cardiovasc./Respir. 5-Day Range-Finder Enzyme Induction Immunosuppressi'on - (1980' 'Mod'erately! Irritating MTD' = 3750 mg/kg, (male rats)! M'TD> = 5000 mg/kg (female rats)! MTD = 1500'mg/kg (male mice) MTD = 7'501mg/kg (female mice). 0 SOURCE: Naard!en *Testing stopped14['83 COMPOUIV'D: d-Limonene,, P'&F (B102): 14-Day Subacute Ames Assay Mouse Lymphomal Rabbit Eye Cardiowasc./Respir. 5-Day Range-Finder Enzyme Induction Immunosuppression 4'342 mg/kg (combined sexes, i.p.). - (Confirmed) Minimally Irritating M'ID1= 1750 mg/kg (males)' MTD1= 750 mg/kg, (females)' 0 (females),, - (males) SOURCE: Naarden (RY2'633'1)'; Gliddeni(SCM Terpene Products) y

CiOiWIPOUND': Alcohol (C-8) (Octanol-1)' (B103). 14-Day Subacute Ames Assay Mouse Lymphoma Rabbit Eiye. Cardiovasc. /Respir.. 5-Day Range-Finder Enzyme Induction FEWagvo 2325 mg/kg (males, i.p.) 1858 mg/kg,(females, i.p.) - (Confirmed)i Severely Irritating MTD' = 5000 mg/kg 0 (female mice) Immunosuppression - SOIJRCE~:~~ Naarde~n~ (RY2'8000)!;Givaudan COMPOUND: Aldehyde (C*-11) 10-UNdecenal (B104)'* LD50 Ames Assay - (198'1') Mouse Lymphoma - Rabbit Eye Mildly Irritating. Cardiovasc./Respir. Insoluble Multi-Dose Range-Finder MTD 7 ' = 5000'mg/kg, Enzyme ][nduction - (sleep times)** Immunosuppression SOURCE:A]drich Chemical Co,. *Testing stopped 7/83' **Insufrfricient data to evaluate in vitro studies due to toxicity in the rat ***Higher mean~spleen weights in B104 - treated1mice.

COMPOUND: Linalool RY26352' (B105) CONFIDENTIAL F~F ~M, Pr .7~~6~ 3~~5 14-Day Subacute Ames Assay Mouse Lymphoma Chromosomal Aberration 68'7 mg/&g (combined'sexes, i.pj - (Conf irmedi) + (With Activation). - V Rabbit Eye Rabbit Eye (low dose)', Moderately Irritatiing, * Cardiovasc./Respir. - 5-Day Range-Finder Enzyme Induction MTD = 750!mg/kg (males) NtTD = 3750 mg/kg (females)'. 0' Immunosuppression - (?') *Not retested since usage level x 100 exceeds tested dose SOURCE: Naarden C©NIFOLTDID: a-Terpineol RY30452 (B106) f tr- n A , 3p4S 14-Day Subacute Pending Ames Assay - (Confirmed) Mouse Lymphoma - Rabbit Eye Moderately Irritating Cazdiovasc./Respir. - 5-Day Range-Find'er 1KTD' = 1375 mg/kg, Enzyme Indwction 0. Immunosuppression: i. SOURCE':- Naarden O' O O . ~ ca

C0MPOITND: Geranyl Acetate RY25091 (B107) 114-Day Subacute Pending, Ames Assay - (Confirmed) Mouse Lymphoma + (with Activation). Chromosomal Aberration - Rabbit Eye Minimally Irritating. Rabbit Eye (low dose)'~ Minimally Irritating. Cardliovasc./Respir. - > 5-Day Range-Finder MTD = 5000 mg/kg (rats). PE/''lpr mtS© q ~ MTD = 2'500' mg/kg, (male mice)' MTD = 1875' mg/kg, (f emale mice) Enzyme Induction + Immunosuppression - SOURCE': Naarden CoMPOUND : 2'-A-3MP' (B!1o8) (Rats, p.o.)' 448'mg/kg (females) LD 50 529 mg/kg (combined sexes). LDS0 (Mice). 450 mg/kg ('i.p.) Ames Assay - (Conf irmed). Mouse Lymphoma! - Rabbit Eye Moderately Irri.tating, Rabbit Eye (low dose), Minimally Irritating Cardiovasc./Respir. - 5-Day Range-Finder MTD = 375 mg/kg (males) MTD = 3I1i3 mg/kg, (,females) Enzyme Induction -* Iimmunosuppxession - 114-Day Toxicity** Significant increase in absolute and relative liver weights in 20'0' mg/kg females *Significantly increased liver/body wt. ratio (both sexes)~ **50,100,, and 200 mg/kg, SOU'RCE':PyrazineSpecialists J_, np

C O1dFIDENT IAL COMPOUND: New Engiand' Rum Flavor 2A-45092 (BI09)':* LD50 (i.p.) 14-Day Subacute 1592 mg/kg (males)', 1736 mg/kg (',females) 826 mg/kg (males, i.p.) ~:. 788 mg/kg, (females,, i.p.). -I( . Ames Assay Mouse Lymphoma Cardiovasc../Respir. 5-Day Range-Finder Enzyme Induction Immunosuppression *Replaced'B40 - (Contracted) Pending Insoluble MTD = 1750 mg/kg (males)'. MTD = 3125 mg/kg (females)'. 0' (,female mice). S©URCE: Naarden COMPOUND: Casing, 9/706856 (no cocoa) (B110') (Replaced B76)'. 14-Day Subacute Ames Assay Mbuse Lymphoma *Rabbit Eye - *Rabbit Eye (low dose)! Cardiovasc./Respir. *5-Day Range-Finder *Enzyme Induct.ion. *Immunosuppression *B76 tested SOURCE: Dragoco s = 5000 mg/kg (ip) - ('Contracted)

CONFIDENTIAL. COMPOUND~: Tobacco Flavor 52.480 (no cocoa) (B1'1i1) (Replaced B81). 14-Day Subacute Pending Ames Assay - (Contracted) Mouse Lymphoma + (With,Acti'vation)'*** Mouse Lymphomal (Rerun) Pend'ing, *Rabbit Eye **Rabbit Eye (,low dose)! *C~ardiovasc.['Resp3:r. Insoluble *5-Day Range-Finder *Enzyme Indliction *Immunosuppression *B81 tested' **Initial test performed wi'th B81. Not retested since usage level x 1Wexceeds tested dose. ***Weak + SOURCE: Firmenich COMPOUND: Artificial Chocolate 1924 (no cocoa)l (B112) (Replaced B85). 14-Day Subacute 644 mg/kg,('males,,ip) 549' mg/'kg (females, ip)~ Ames Assay - (Confirmed) Mouse Lymphoma + (with & without Activation) Mouse Lymphoma (Rerun)~.. Pending *Rabbit Eye**'Rabbit Eye (low dose)l . PracticallyN'on-Iirritating, **~r Cardiovasc./Respir. - > Multi-Dose Range-Finder = 5000' mg/kg *Enzyme Induction Pending *Tmmwnosuppression Pending, Terat./Repro. Pending, *B85 tested *~*Tested at high dose as B85 ***Equivocal results for B85' SOURCE: William Bell -11

COMROIJh'D: Walnut CD7'9423' (no:cocoa) (B113) (Replaced B88). *LD5© 14-Day Subacute >5000 mg/kg Ames Assay - (Contracted) Mouse Lymphoma - *Rabbit Eye Card'iovasc./Respis. - *5'-Ds.y Range-Finder *Enzyme Induction *Immunosuppression *B88, testedl SOURCE: hTaarden COMPOUND: Tobacco Sweetener (B114) LD50, 9364 mg/kg (i.p.) 14-Day Subacute >5000 mg/kg (i.p.)' Ames Assay - (Contracted)' M'ouse Lymphoma Rabbit Eye " Mildly Irritating Cardiovasc./Respir. Insoluble > 5-Day Range-Finder 1rITD = 5000 mg/kg Enzyme Induction - Immunosuppression - SOURCE~: Crompton-&nowles

COMPOUND: 0'i]J, Cardamon L00689 (B11'5), 14-Day Subacute Pending Ames Assay - (Confirmed) Mouse Lymphoma - Rabbit Eye Mildly Irritating, Rabbit Eye (low,dose) * Cardiovasc./Respir., - 5-Day Range-Finder MTD = 3125 mg,/kg (males), MTD' = 3750 mg/kg (',f emales)' CONFIDENTIAL Enzyme Induction, + Immunosuppression, - *Not retested since usage level x 100 exceeds tested dose. SOURCE:' Naarden COMFOUND: Caramel - Flavor "'T" (!B116). LDp >4320' mg/kg (i.p.) 14-DaySuliacutePendi'ng Ames Assay - Mouse Lymphoina Rabbit Eye Minimally Irritating Cardiovasc.,/Respir. - = 5000' mg/kg, 5-Day Range-Finder MTD1> Enzyme Induction Immunosuppressi:on SOURCE: Sethness Products .:p

COMPOUND: Corn Syrup - High Dextrose (B117) LD50 Ames Assay Mouse Lymphoma Cardiovasc./Respir. 5-Day Range-Finder Enzyme Induiction CONFIDENTIAL Immunosuppression. SOURCE: Cargill; Grain Processing; CPC International;, Corn Sweeteners COMPOUND: Oil, Sage - Dalmation, USP' (g1]I8), FE't'jiA! oZ60'1i Mouse Lymphoma Mouse Lymphoma (Eterun), Rabbit Eye Cardiovasc./Respir. 5-Day Range-Finder Enzyme Induction Immunosuppression 433 mg/kg (males)' 302 mg/kg (',females), 158' mg/k& (males, i.p.) 118' mg/kg(females, i.p.) - (Contracted) + (With Activation). Pending Mildly Irritating, MTD = 313'mg/kg,(maSe rats) MTD =' 1'75 mg/kg (female rats) MTD = 1188 mg/kg (mice) + (rats) SOURCE: Crompton-Knowles; Norda k

COMPOUND: Sugar„ Dark Brown (B119) LDSO Ames Assay Mouse Lymphoma Rabbit Eye Rabbit Eye (low dose)', Cardiovasc./Respir. 5-Day Range-Finder Enayme:Induction Immunosuppression SO!URCE~r.National Sug~ar;~~ Sauannah~Sugar; Colonia~~1;~ American Sugar; Codchaux-lienderson COMPOUND~: Balsam Tolu, USP Cleaned (B120) LD0 > 5000 mg/kg (p. o. ) Ames Assay - (Contracted) Mouse Lymphoma Cardiowasc./Respir. Insoluble. 5-Day Range-Finder Pending, Enzyme Induction, Pending, 7[mmunosuppression Pending, S017RCE': J. Brampton ~:

COMPOUND: Powdered Vallerian Root (B12'1) LDp, >2'50&mg/kg (p.o) 14'-Day Subacute >5000 mg/kg (p'.o.). Ames Assay * Mouse Lymphoma Rabbit Eye Severely Irritating Cardiovasc./Respir. Insoluble 5-Day Range-Find'er MTD > ' = 5000 mg/kg Enzyme Induction Immunosuppression CONFIDENTIAL SOURCE: Meer. *all lots contaminated with microbiological agent COMPOUND: Tobacco Flavor BB-701C (B122) (Replaced B67). *1:D5© 14-Day Subacute 1691 mg/kg (males, ip) ~ 1048 mg/kg ('females,~ ip) Ames Assay - ('Conf irmed) Mouse Lymphoma - *Rabbit Eye *Cardiovasc./Respir. *5-Day Range-Finder *Enzyme Induction *Immunosuppression *B'67 tested SOURCE: Tobacco Technology y

COb[POUND: Oil o Almond Bitter (',B123)',* LD 501 Ames Assay Mouse Lymphoma Cardiovasc./Respir. - 5-Day Range-Find6r MTDi = 1375:mg/kg, (malles) , Enzyme Induction Immunosuppressi'on *Testing stopped 4/83' SOURCE: Aroma Resources MTD = 750 mg/kg, (females) COMPOUND:: Tobacco (Lovage) (B'124)~*' LD50: Ames Assay Mouse Lymphoma . Cardiovasc./'Respir.. Iinsoluble 5-Day Range-Finder MTD = 3750 mg/kg (males) MfiD: = 3'125) mg/kg (£emales)! Enzyme Induction +++ Immunosuppression - *Testing stoppedl 4/8'3 SOURCE: Firmenich

COMPOUND: Flavor No. 7932 (B125) 14-Day Sulbacute 610 mg,/kg, (maLes,, ip) 656 mg/kg (,females, ip) Ames Assay Mouse Lymphoma - (Contracted). Cardiovasc./'P,'espir. - 5-Day Range-Finder MTD = 5000 mg['kg, Enzyme I[nd'uction 0 Immunosuppression - SOURCE: Lorillard Flavor COMPOUND: Flavor No.. 7826 (B126)'. LD50 Ames Assay Mouse Lymphoma Cardiovasc./Respir. 5-Day Range-Finder Enzyme Inductioni Immunosuppression~ SOURCE: Lori'llard'Flavor TD' ' 5000 mg/kg ('ma]ies) MTD' = 3'1125 mg/kg (',femal'es)~ CONFIDENTIAL

COMPOUND: Ethyl Vanilllin (B127) CONFIDENTIAL Fc: MA 4464 D4-Day Subacute Pending Ames Assay - (Contracted) Mouse Lymphoma + (with Activation)* (L,itton), Mouse Lymphoma Equivocal (With Activation) (Micro)i Rabbit Eye Mildly Irritating Cardiovasc./Respir. 5-Day Range-Finder Enzyme Induction Immunosuppreseion *weak+ S0!URCEI: Aroma Resources MTD1= 5000' mg/kg COMPOLTND: Veratrald'ehyde ('B1128)' 'FEMA 3.1011 1'4-Day Subacute 815 mg/kg (males, ip)! 612 mg/kg, (females, ip)' Ames Assay - (Contracted)~ Mouse Lymphoma + (with and without Activation)', (Litton), Mouse Lymphoma + (With Activation) (Micro). Rabbit Eye Mildly Irritating Cardiovasc,/Respir. - 5-Day Range-Finder MTD = 750!mg/kg (males) MTD = 17501mg/kg (females): Enzyme Induction + (mice)'. Immunosuppress3!on SOURCE: Aroma ResourcesO O O ~ -- ~ . ~ CD

COMPOUIQD: Heptanoic Acid (B129) C ONT ID EriTTIAL FlEflF1' 3' 3 Ef 4" 14-Day Subacute 567 mg/kg,(males, ip) 569 mg/kg,(females, ip) Ames Assay - (Contracted)' ~ s~ Mouse Lymphoma . + (with Activation)~ -V Chromosomal Aberration: - Rabbit Eye Extremely Irritating Cardiovasc./ltespir. Insoluble 5-Day Range-Find'er MTD' =:1750 mg/kg,(males) MTD' = 3750. mg/kg, (females). Enzyme Induction - Immunosuppression - * Weak + SOURCE: Aldrich Chemical Co.. COMPOUND: Hexanoic Acid (B130) FEMA a: c*sq; 14-Day Subacute (i.p.) 14-Day Subacute (p.o.) Ames Assay Mouse Lymphoma Rabbit Eye Cardiovasc./'Respir. 5-Day Range-Finder M'uwlti.-Dose Range-Finer Enzyme.Indhiction Rerun~ p.o. due to low pH P'end ing - ('.Contracted)'. + (with Activation)' Maximally Irritating Insoluble tK7PD'> . = 5000 mg/kg (rats) FITD = 532 mg/kg (mice). 0 Immunosuppression - i-. SOIURCE: Aldrich Chemical Co.

COM~PoUND: Isobutyric Acid (B'131) 14-Day Subacute (oral)' Ames Assay Mouse Lymphoma Chromosomal Aberration~ *Rabbit Eye (low dose). Cardiovasc./Respir. 5-Day Range-Finder Multi-Dose Range-Finder Enzyme Induction Immunosuppression, 238'8' mg/kg (males) 147'9' mg/kg (females)' - (Contracted)' FEMA + (with Activation) Moderately Irritating, MTD = 17'50 mg/kg ('rats)' MTD = 450 mg/kg (female mice) > MTD = 700' mg/kg, (male mice)' MTD = 438' mg/kg (female mice) CONFIDENTIAL a:.22;z ** * Tested only at low dose since pH = 2.03'. ** results erratic - 14TD could not be determined in male mice SOURC E: Aldrich Chemical COMPOUND: Toliuald'ehyde (B132)' 14-Day Subacute Pending Ames Assay - ('Contracted). Mouse Lymphoma - Rabbit Eye Mildly Irritating Cardiovasc./Respir. Insoluble. FENA 346 g ' 5-Day Range-Finder MTD'= 3125 mg/kg, (rats)~ MTD,= 313 mg/kg (male m3!ce), 625 mg/kg (female mice) Eizzyme Induction 0' Immunosuppression SOURCEI: Civaudan p

COMPOUND: Benzaldehyde (B133)! 14-Day Subacute Ames Assay Mouse Lymphoma Rabbit Eye Cardiovasc./Respi'r. 5-Day Range-Finder Pending - (Contracted). +(withiActi'vation)'. Moderately Irritating Inso1'ub le MTD = 1375 mg/kg CONFIDENTIAL F1-:11'16 -2-4.27 Enzyme:Induction -* Immunosuppression - *Some toxicity in female mice SOURCE: Aroma Resources CQMPOUND': Vanitrope (B134) Ir"a 14-Day Subacute Ames Assay Mouse Lymphoma Rabbi',t Eye Cardiovasc./Respir. 5-Day Range-Finder FEM 4 P4k;L 142'2' mg/kg (males,, i.p.). 1827 mg/kg (females, i'.p.). - (Contracted) + (with Activation). .MinimalTyItritating, Insoluble MTD = 5000 mg/kg Enzyme Induction 0' ('~mice)', Immunosuppression At, SOURCE: U.O~.P. Chemicals

COMPOUND: gammai1Vonalactone (B135) FIGMA'. 33T-4 a.a.a.- hha dJw-~l~~ fr~ti' c~ ca'ci4 ) r- la c,i~',t,-t_ 14-Day Subacute Pending Ames Assay - (ContracteO Mouse Lymphoma + (with Activation), Rabbit Eye Minimally Irritating Rabbit Eye (low dose). Cardiovasc./Respi!r. - 5-Day Range-Finder MTD = 3'125 mg/kg Enzyme Induction 0'(mice), Immunosuppression - SOURCE: Elan Chemicals COMPOUND: Suporesin Celery (8136)*' LD50 Ames Assay Mouse Lymphoma Rabbit Eye Rabbit Eye (low dose) Card'iovasc./'Respir. 5-Day Range-Finder Enzyme Induction. Immunosuppression *File closed 8'/82' SOURCE: Fritzsche AN, ,;. 9

COMPOUND: Tincture Orris Root (B137) CONFIDENTIAL 14-Day Subacute 4'729 mg/kg (comb. sexes,, Ames Assay - ('Contracted). Mouse Lymphoma Cardiovasc./Respir. - > 5-Day Range-Finder MTD = 5000'mg/k$ Enzyme Induction - Immunosuppression - SOURCE: Meer COMPOUND: ChamomiSe, Solid Extract (B'138)~ 14-Day Subacute Pending Ames Assay -('Contracted'). Mouse Lymphomai Cardiovasc.[Respir. - > 5-Day Range-Finder MTD, = 5000 mg,/kg Enzyme Induction - Immunosuppression - SOURCE: Meer p

COMPOUND: Tobacco 53.458 ($139)~ 14-D!aY! Subacute Pending Anes Assay - ('Contracted) Mouse Lymphoma Cardiovasc.['Respir. - 5-Day Range-Find'er >5000mg/kg, Enzyne~ Induction + (male~ mic~e)~. Immunosuppression - SOURCE: Firmenich COMPOUND: Corn Silk, Solid Extract (B140). 14-Day Subacute Pending Ames Assay -(Contracted) Mouse Lymphoma C_ardiovasc. /'Respir. - 5-Day Range-Finder >5000'mg/kg Enzyme Induction + (male mice). Immunosuppressi'on - CONFIDENTIAL p p SOURCE: Meer

COMPOUND:: Tobacco 53.415' (BS41) CONFIDENTIAL 14-Day Subacute Ames Assay Mouse Lymphoma P'ending, Pendi'ng, . Cardiovasc./Respir. ' - Mul ti-Dose Range-Find'er Enzyme Induction Immunosuppression MTD = 1375 mg/kg Pending SOURCE: Firmenich COMPOUND: Tomato, Artificial 57.635/A (B142). 14-Day Subacute Pending .+~. Ames Assay Mouse Lymphoma -(Contracted)~ Cardiiovasc. /P,espir.- 5-Day Range-Finder >5000:mg/kg Enzyme Induction 0. (mal'e rats) Immunoeuppression SOURCE': Firmenich

COMPOUND!: Absolute Hubulon (Hops) (B143) 14-Day Subacute Pending, Ames Assay -(Contracted) Mouse Lymphoma Cardiovasc./Respir. Insoluble Mu1ti-Dose Range-Finder MTD- 1375 mg/kg Enzyme Induction Immunosuppression Pending, SCIURCE: Camilli, Albert &:Laloue COMPOUND:Linalyl Acetate (B144)'* LD5O Ames Assay Mouse Lymphoma Cardiovasc./Respir. 5-Day Range-Finder Enzyme Induction Immunosuppression *File closed 8/82 SOURCE: Naarden CONFIDENTIAL FEMA .2636 x

COMPOUND: Tetramethyl Pyrazine (B1i4'5) 14-Day Subacute Pend!ing Ames Assay - ('Contracted). Mouse Lymphoma Cardiovasc./Respir. - Multi-Dose Range-Finder 14TD = 1750 mg[kg Enzyme Induction 0 Immunosuppression - SOURCE: Pyrazine Specialties COMPOUND: p-Cresol Methyl Ether (B146) 1!4-Day Subacute P'ending, Ames Assay - (Contracted) Mouse Lymphoma Cardiovasc.[Respir. - Multi-Dose Rangp-Finder MTD = 1750'mg/kg, (males) MTD = 1375 mg/kg (females) Enzyme Induction Pending Immunosuppression - SOURCE: H & R - Norda

COMPOUn'D: Ethoxyacetic Acid' (B147). 14-Day Subacute Pending. Ames Assay - (Contracted). Mouse Lymphoma Cardiovasc,./Respir. - Multi-Dose Range-Finder hTD = 137'5 mg/kg (males). PYTD = 75.0 mg/kg (females) Enzyme Induction. Pending Immunosuppression - SOURCE: Takasago * COMPOUND: Genet Absolute (Broom) (B148)~ LD50 Ames Assay Mouse I.ymphoma. Cardiovasc.[Respir.. 5-Day Range-Finder Enzyme Inducti'on Immunosuppression *'File closed'111/82 SOURCE: CAL F EnnA ISa4 F 9

COMPOUND: Artificial Nut 53.407 7 (B149)~ 14-Day Subacute Pend'ing, Ames Assay - (Contracted) Mouse Lymphoma Cardiovasc./Respir. - > 5-Day Range-Finder MTD = 5000 mg/kg Enzyme Induction CONFIDENTIAL Immunosuppression - SOURCE: Firmenich COMPOUND: Flavor No~., 7~,838' (B15~~0)~ (Formulation Ch~~ange~ - New~ B163) LD50 Ames Assay - (Contracted) Mouse Lymphoma - Rabbit Eye Extremely Irritating, Cardiovasc./Respir. Insoluble 5-Day Range-Finder MTD = 3750 mg/kg Enzyme Induction + Immunosuppression SOURCE: Lorilliard Flavor _p

COMBOUND: Benzyl Alcohol, N.F. (B15S). FEMA 2131 14-Day Subacute Ames Assay Mouse Lymphoma Cardi:ovasc./Respir. 1811 mg/kg (,i.p.,, combined sexes), -(Contracted) - V Multi-Dose Range-Finder Enzyme Induction Immunosuppression MTD' = 1375 mgf kg - SOURCE: Givaudan COMPOUND: Flavor No. 8048 (B15:2) 14-Day Subacute 2'743' mg/kg (males, i.p.) ~ •~ - Ames Assay Mouse Lymphoma Cardiovasc./R'espir. 3001 mg/kg (females, i.p.)I -('Contracted) - , . riulti-Dose Range-Finder Enzyme Induction MTD = 312'5 mg/kg (mal:es) MTD = 3750 mg/kg (!females) 0 Immunosuppression - SOURCE: Loriililard Flavor

COMPOUND: Octanoic Arid (B153)' FeMA , 2111 14-Day Subacute 1264 mg/kg (males, i.p~. ) 1000 mg/kg (females, i.p:.) Ames Assay -(.Contracted) Mouse Lymphoma Cardiovasc./Respix. - 5-Day Range-Find'er MTD > = 5000 mg/ltg. Enzyme Induction, Immunosuppression - SOURCE: Aldrich Chemicali Co. COMPOUND: a]:pha Pinene (B154). FEn01 29'a2, 14-Day Subacute 3557 mg/kg (males, i.p.). 1683 mg/kg (females, i.p.) Ames Assay - ('Contracted) Mbuse Lymphomal Cardiouasc./'Respir. - Multi-Dose Range-Finder MTD = 750'mg/kg Enzyme Induction 0 (mice). Immunosuppression SOU'RCE: Clidden

COMPOUND: beta P'inene (B155) FEMA A% 3 14-Day Subacute 33'8'7 mg/kg (males, i.p.) 3415 mg/kg, (females, i.p.) Ames 2issay -(Contracted) Mouse Lymphoma Cardiovasc./'Respir. - Multi-Dose Range-Finder IyITD = >2500 mg/kg (males) M'TD = 1750 mg/kg ('femal:es) Enzyme Induction 0' Immunosuppression - SOURCE: Glidden COMP0UND: gamma Terpinene (',B156)i 14-Day Subacute 3'2'03 mg/kg, (males, i.p.) 2236 mg/kg (females, i.p.) Ames tlssay - (Contraeted), Mouse Lymphoma Cardiovasc./Respir. - Multi-Dose Range-Finder MTD. = 1375,mg/kg Enzyme Induction 0 Immunosuppression SOURCE: Glidden _P

COMPOUND: Isoeugenoi (B'1I57), FFM4 aW68. 14-Day Subacute 261 mg/kg (males, i.p.)i 309' mg,/kg, (females, i,pi. )', Ames Assay - ('.Contracted) Mouse Lymphoma Cardiovasc./Respir. - Multi-Dose R'ange-Finder MTD = 1375 mg/kg (males) MTD' = 1750 mg/kg, (females)~ Enzyme Induction, 0' (female rats). Immunoswppression P'ending, SOURCE: Fritzsche - D1& 0 COMPOUND'.: beta Caryophyllene (B1'S8) FEMAI 2252. 14-Day Subacute >7940' mg/kg (males, i.p.), 5953 mg/kg,(females, i.p.) Ames Assay - (Contracted)' Mouse Lymphoma Cardiovasc./Respir. Insoluble 5-Day Range-Finder MTD,> = 5000' mg/kg Enzyme Induction ++ Immunosuppression SOURCE: CA Aromatics

COMPOUND: Artificial Peppermint #514 ('B159)* LD50 Ames Assay - (Contracted) Mouse Lymphoma Oardiovasc./Respir. - Multi-Dose Range-FYnder NITD = 1375 mg/kg (males). MTD:= 175 mg/kg (femalies)' Enzyme I'nduction + Immunosuppression SOURCE: Glidden *Testing, stopped 8/83I OOMPflLTND: Flavor ho. 7'981 (B160)* LD50 Ames Assay - (Contracted) Mouse Lymphoma Cardiovasc./Respir. - Multi-Dose Range-Finder MTD = 3750 mg/kg (males). r'ITD= 3T2'5mg['kg (females) Enzyme Induction. Immunosuppression 80URCE: Lorillard Flavor *Testing stopped 8/8'3''.

CONFIDENTIAL COMPOUND: Clove Leaf Oil (B161) FEMA 2325' LD5© L4-Day Subacute Ames Assay Mouse Lymphoma Cardiovasc. /Respir. Multi-Dose Range-Finder Enzyme Induction Immunosuppression 476 mg/kg (i.p.) Pending - (,Contracted) Pending MTD = 350 mg/kg,(males) MTD = 750 mg/kg ('~females) 0 (rats) - SOURCE: Naardien COMPOUND: *Ground~~ C~loves~ ($'162') t'EMq -M-1 LD50, Insoluble. Ames Assay Insoluble Mouse Lymphoma. Cardiovasc./Respir. Insoluble Multi-Dose Range-Finder Enzyme Induction Immunosuppression *No testing, due to~ insolubility in biological vehicle - testing stoppedi 3I/84 SOURCE: Meer .-,

CChiP0U1'JD: Flavor No. 8133! (,B163')' (Replaced BI50)~ 14-Day Subacute: 2'589 mg/kg,(male , i.p.) 2743 mg/kg,(females, i.p.)i Ames Assay -(Contracted), Mouse Lymphoma C'ardiovasc./Respir'. Insoluble5'-Day Range-Finder MTD > = 500'0 mg/kg Enzyme Induction Pending Immunosuppression - SOURCE: Lorillard Flavor COMPOUND.: Cardamon Powder 0'16'4)' FEndA 22qo 14-Day Subacute >500 mg/kg (oral, combined sexes) Ames Assay Insol.uble. Mouse Lymphoma Cardiovasc./Respir. Insoluble > 5-D'ay Range-Finder 1fITD!= 5000 mg/kg Enzyme Induction 0 (male rats) Immunosuppression Pending SOURCE~:! M'.F. Neal &: Co., i 'Ir

C'OMPOUND: Flavor No. 8133 (B163')' (RepllacedIB150). 14-Day Subacute Ames Assay Mouse Lymphoma Cardiovasc./Respir. Pending Pending a sa Range-Finder ~ (~rlb y ~tc~'~ Enzyme Induction Pending, Immunosuppression Pending SOURCE: Lorillard Flavor COMPOUND: Cardiamon Pbwder (s1164)' LD50 Ames Assay Fending Mouse Lymphoma Cardiovasc./Respir. Insoluble 5-Day Range-Finder MTD = 5000 mg/kg Enzyme Induction Pendi:ng Immunosuppression Pending "SOURCE: M.F. Neal & Co.

C OrTF tiD EIVT IAL C0MP0UND: Flavor Nb. 1264 (B'165) 14-Day Subacute 14,70'-2150 mg/kg (combined sexes, i.p.)'. Ames Assay - Mouse 1:ymphoma. Cardiovasc./Respir. Insoluble 5-Day Range-Finder MTD1> 5000 mg/kg, Enzyme Induction Pending Immunosuppression - SOURCE: LRC COMPOUND: 2'-Ethyl-3,5(6)-dimethylpyrazine (B166)', 14-Day Subacute 119 mg/kg,(males, i.p.)'. 133 mg/kg (females, i.p.) Ames Assay - (Contracted) Mouse Lymphoma Cardiovasc./Respir. 0 Multi-Dose Range-Finder MTD = 3'13 mg/kg,(males). MTD = 375 mg/kg, (fe.males) Enzyme Induction Pending, Immunosuppression Pending, SOURCE: ' Pyrazine Specialties .~,

COMPOUND: Raisin Replacer JR-05-1I31 (B167)* 14-Day Subacute Pendi'ng, Ames Assay ' -(Contracted) Mouse Lymphoma Cardiovasc./Respir. Pending 5-Day Range-Finder Pend'ing Enzyme Induction Pending Immunosuppression Pending *Replaced B90 SOURCE: Naarden COMPOUND: Sucrose Octaacetate (,B1~68) LD50, Ames Assay Pending, Mouse Lymphoma Pending, Cardiovasc./Respir. Pending Mu]lti-Dose Range-Find6r Pending Enzyme Induction Pend'iing, Immunosuppression Pending. CONFIDENTIAL FEA"IA 3D3$. P SOURCE: ICN Pharmaceuticals, Inc. (K&K)

CONFID 1VTIAL COMPOUND: Artificial Sweet Mint Menthol Enhancer 275-42'-OQ (B169) 14-Dayr Subacute Pending Ames Assay P'end'ing, Mouse:Lymphoma ~,. s Cardiovasc./Respir. Pending, Multi-Dose Range-Finder Pending Enzyme Induction Pending Immunosuppression Pending SOURCE: Firmenich COMPOUNDi: Tobacco Casing Flavor, Pineapple 0/'13U462'(B17'0) LD50 , Mouse Lymphoma Cardiovasc./Respir. 5-Day Range-Finder Enzyme Induction Immunosuppre5sion Source: Dragoco,,Inc. i

COMPOUND: Tkiethyi Citrate (B1i71), (No Testing, - See SCOGS Report) LD5U Ames Assay Mbuse Lymphoma Cardiouasc./R8splir.5-Day Range-Finder Enz}-me Induction I[mmunosuppression seerresti Eastman Organic Chemicals SIOURCE: <J COMPOUND : LD5©, Ames Assay Mouse Lymphoma Rabbit Eye Rabbit Eye (low d'ose) Cardiiovasc./Respi'r. 5-Day Range-Finder Enzyme Induction Immunosuppression CONFIDENTIAL F€m A 3083 SOURCE: _5~

ColtiiPOUND: rTXcictj Sweef`"' Min + &n4Ac f ~ hxnee r 27-'F-,l'.z-t z r__ m____ LD50, Ames Assay DNA Alkali'ne Elution Mouse Lymptioma Rabbit Eye Rabbit Eye (low dose). Cardiovasc.,/Resplr., 5-Day Range-Findtr Enzyme Induction Immunosuppression s r"f:`mLT1 iC:n COMFOiJNID : DecisioniTree LD50 Ames Assay DNA Alkaline Eliution Mouse Lymphoma R'abbiit Eye Rabbit Eye (low dose) Cardiowasc./Respir. 5-Day Range-Finder Enzyme Induction. Immunosuppressi'on

CUM'F©UND : c ~1 Q I, Swee-l'"' Mii~,nif M~2?14tc e V ~h.xn~er~Zs-y,z-bz ~C3~ ~~R~ T.- _ T__ _ LD50 Ames Assay DNA Alkaline Elution Mouse Lymphoma Rabbit Eye Rabbit Eye (low dose) Cardiovasc, /Respir.5-Day Range-Finder EnaymeInd'uctionImmunosuppression . rt rtr1 E nr fA COMPOiJND:. Decision Tree. LD50 Ames Assay DNA Alkaline E'Iution Mouse Lymphoma Rabbit Eye Rabbit Eye (low dose). Cardiovasc./Respir. .5-Day Range-Finder Enzyme Indbcti:on Immunosuppression ,(. X s