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COMPOUND: Oil of Anise-USP(B'1) Il,D50 868 mg/kg (i. p. ) Ames Assay Mouse L.ymphoma Rabbit Eye Rabbit Eye (low dose) Cardiovasc./Respir. 5-Day Range-Finde.r Enzyme Induction Immunoswppressio!n - SOURCE: Magnus, Mabee &' Reynard; Ungerer (#2856) COMPOUND: Alcohol-Specially Denatured (190 Proof) (B2') (NO 'LESTING)~ Z.D50 Ames Assay Mouse hymphomal Rabbit Eye Rabbit Eye (low dose). Card'iovasa. /'Respir. 5:-Day Range-Finder .EnzymeI[nduction Immunosuppression SOURCE: U.S. Industrial; Union Carbid'e; Publicker; Shell; Devon r

COMPOUND: Benzodihydropyrone CONFIDENTIAL (B3) C-f A ' 38f 2' 0 r . f LD'50 694 mg,/'kg,(i.p.) 14-Day Subacute (i.p.). 774 mg/kg (males)'. 7111 mg/kg (females) ;1 :01 Ames Assay Mouse Lymphoma Mouse Lymphoma (Rerun) Chromosomal Aberration Rabbit Eye - (Confirmed)l + (With Activation)'* Pending, + Rabbit Eye (low dose)' Cardiovasc./Respir. 5-Day Range-Finder Enzyme Induction Minimally Irritating MTD = 3125 mg/kg,(males). MTD' = 1376 mgfkg, (females). - Immunosuppression - *We k + a SOURCE: Givaudani; Arsynco COMPOUND: Balsam Tolu! (B4)' Il.D50 Ames Assay Mouse Lymphoma Cardiovasc./'Respir. 5-Day Range-Finder -(Con€irmed)'. Insoluble . Enzyme Induction .~ Immunosuppression SOURCE: J. Brampton O O. O. Q? 2v~ N

COMBOUND:~ Artificial Chocolate 59~~.~457' (B5)~ . LD50' ..1004 mg/kg (i.p.) Ames Assay - Mouse Lymphoma Rabbit Eye Rabbit Eye (low dose) Cardiowasc.,/Respir. 5-Day Range-Finder Enzyme Induction Immunosuppressiom SOURCE: Firmenich COMPOUND: Artificial Coumarin 2134 ($6) LD50 1085' mg[kg, (i.p.) Ames,Assay - Mouse Lymphoma Rabbit Eye Rabbit Eye (,low dose)i Cardiovas~~c. ~/'~Respir~. 5~-Day Range-Find6r Enzyme Induction Iimmunosuppress3on SOURCE: Crompton-Knowles P

COMPODND:! Artificial Dark Chocolate 377IIl (B7). LD5© 6376 mg/kg, ( i. p. )_.._ Ames Assay - Mouse Lymphoma Rabbit Eye Rabbi't Eye (low dose) Cardiovasc./Respir. 5-Day Range-Finder Enzyme Induction. Immunosuppression. SOURCE: Crompton-Knowles COMPOUND': Artificial Coumarin 2749 (B8'). LD50 ll29'2 mg/kg (i.p. ) Ames Assay - Mouse Lymphoma Rabbit Eye Rabbit Eye (,low dose) Cardiovasc./'Respir. 5-Day Range-Fi'ndier. Enzyme Induction, Immunosuppression, SOURCE: Crompton-Knowles .r:

C:CNPOtND : Oil Cardaaan (B9) , LD5Q 14-Day Subacute Ames Assay Mouse Lymphana FEnA aa-4 f 757 mg/kg (i.p. )' 1337 mg/kg (males, i.p.) 1105 mg/kg (ifemales; i.p. ). - (Cbntracted) - Rabbit Eye Cardiovasc. /1Respir. 5-Day Range-Finder Enzyme Induction Non.-irritant. - (Insoluble according to naewof 7/2/83) MTD'= 5000 mlg/kgj(males) IuIID, = 2500 mg/kg, (females) + Intrnuwsuppression - SOURCE:NordaCONiPOUNID : Oil, Coriander (810') FEM ~~,, 3 3 q LD50, 1440 mg/kg ('i.p.), 14-Day Subacute A:nes Assay Mouse Lymphcanal 1254 mg/kg (males, i.p.) 1001 mg/kg (females, i.p. ), - (Confirmed). - Rabbit Eye Rabbit Eye (low dose)', CardYavasc. /Respir. 5rDay Range-Finder Enzyme Induction Immmosuppression Severely Irritating Minimally Irritating -(!Insoluble accord:ing to ir+enxx of 7/2/82)1 MTD = 2500 nxg/kg (males) MTD = 11250' mg/kg (females) : O Q SOURCE: Crompton-Knaales; Folarane; Arcana Resources.

COMPOUND: Oil of Clary Sage ('B11) LD5© 1262 mg/kg ('i.p.)i Ame s As s ay - Mouse Lymphoma Cardiovasa./Respir. 5-Day Range-Finder Enzyme Induction Immunosuppression SOURCE: Ungerer COMBCUND:6-1rTeth,y]JBenz~opy~rone(B12) FsmA a6-49. LDa, > 700, mg/kg (p.o.) 14-Day Subacute Pend!ing Anes Assay - (Contracted) Mouse Lymphoma - Rabbit Eye - Cardiovasc./Respir. - (Insoluble according to memo of 10/I9/'8'3). 5-Day Range-Finder MTD = 750~mg/kg (males), MTD, = 375 mg/kg (females) Enzyme Induction 0 Immunosuppression SOURCE: Givaudan; Norda ,% M

C ONF ID ENT IAL , COMPOUND~: Lor~'illliard' C'onc~entrate~ 2491*' (B~13)~ 14-D'ay Subacute Ames Assay Mouse Lymphoma >5000 mg/kg,(ip)i - (Confirmed). s ~ Card!iovasc./Respir. - 5-Day Range-Finder Enzyme Induction MTD = 5000 mg/kg, - Immunosuppression, - *Consists of B27, B75', B43, B3, B29, B63, and B12 SOURCE: Lorrililardl Flavor COMPOUND: ImitationlChocolate P-4482 (B14) LD50 Ames Assay Mouse Lymphomai Cardiovasc./'Respir.. 5-Day Range-Finder Enzyme Induction Immunosuppression SOURCE: Kohnstamm

COMPOUri]D': Ctiocoiate 13169 (B15) ID50~ Ames Assay hbuse LympTcna Rabbit Eye Rabbit Eye (Iowdose) Cardn.ovasc./Respir. 5-Day Range-Finder Enzyme Induction IrRminosuppression SOURCEc Naarden ]D: Creme de Menthe Concentrate F-2475 (B1O LD50 ' ATres Assay Mbuse Lymphana. Rabbit Eye Rabbit Eye (low dbse)' Cardiovasc./ltespir. 5-Day Range-Finder. Enzyme Induction IPmnxnosuppression S0[7RCEs Givaudan.

COMPOUIVD: *Cocoai#135'3'4110 (B17) LD50 6184 mg/kg (i.p.) Ames Assay - (1977) ,'' Mouse Lymphoma Rabbit Eye + Rabbit Eye (,low dose) Cardiovasc./'Respir. - > 5-Day Range-Finder ILITD' = 5000 mg/kg, Enzyme Induction - Immunosuppression - *Testing stopped 4/23'/'82 - no longer in product SOURCE: International Flavors & Fragrances COMPOUND: (,B18'IS A DUPLICATE OF B9) LD50 Ames Assay Mouse Lymphoma Rabbit Eye Rabbit Eye (low dose). Cardiovasc./kespi'r.. 5-Day Rangp-Finder Enzyme Induction Immuno.suppression SOURCE: %. :

COMPOUND: Oi'L of Clary Sage (B1I9), LD50 Ames Assay Mouse Lymphoma. Rabbit Eye Rabbit Eye (low dose) Card~iovasc./'Respir. 5-Day Range-F:inder Enzyme Indiacti'on Immunosuppression SOURCE: Tobacco Technology COl41PQU'ND': Cinnamon Bark Oil RY22911 (,B20') LD50 Ames Assay NPouse Lymphoma Rabbit Eye - Rabbit Eye (,low dose) Cardiovasc./Respiir.. 5-Day Range-FYnd6r Enzyme llnduction~ Immunosuppression FE01 A,'2q 1 A- SOURCE: N'aardeni