Tobacco Documents Online

DRAFT • • Compares CA filters to polypropylene with data for a number Beitrage zur Tabak. 15 pp 123-128 (CCTS of semivolatile compounds. Also comments on triacetin Formella, K. et al 1992 8455 effects. phenols Wu, Z. and Weeks, J. Ag. Food Chem. 40 pp 1917-1921 (COTS Neutral volatiles relationship to flavor intensity. Gives idea of aerosol, Lon 1992 8311) ran e of leaf level de endin on variet back round J. Essent. Oil Res. 4 pp 113-120 (CCTS RJR data on oil extracted with supercritical C02. Compares aerosol, Coleman W. M. 1992 8394) to CH2CI2 for bri ht and burle . back round Authors compare blond and dark tobacco commercial (Italian) cigarettes. Dark tobacco somewhat higher in SS aromatic Pieraccini G. et at 1992 Ra id Comm. Mass S ec. 6 406-409 aromatic amines. See about 2 n!ci t amines Studied MS and SS for cigarettes sold in the UK. Also used Sct. Total Environ.136 pp 101-109 (CCTS 2R1 and 1 R4F, has B[a]P values for both. Sales weighted Evans, W. H. et al 1993 8433) data also. PAH Italian group tested several brands, including Marlboro. Data aromatic Luceri F. et al 1993 Toxicol. Ind. Health 9 pip 405-413 rovided for a lon list of aromatic amines. Gauloise hi hest, amines Recent data for US cigarettes and for some low ignition Brunnemann, K. D. et Food Chem. Toxicol. 32 pp 917-922 (COTS potential models.See Table 1 for B[ajP and nitrosamine PAH, al 1994 8508 values. nitrosamine Vib. Spectroscopy 7 pp 97-111 (COTS FT-IR study of the time course for conversion of NO to NO2 Cueto, R. and P or 1994 8472 in ci are[te smoke. Iso rene involvement back round Used Russian cigarettes, modified filters with additives (not well described). Claim additional removal, but quantitative nitrosamine, Safaev, R. D. et al 1995 Ex erimental Oncolo 17 71-76 data is not t ical. PAH, metals J. Smoking Related Disorders 6 pp 9-23 A review very similar to the changing cigarette. Good Hoffmann, D. et at 1995 CCTS 9057) discussion of filtration, dilution, and other desi n issues. all on list Authors claim the intercept-react method cited prevents loss of analyte. This leads to higher levels of aromatic amines Grimmer G. and even for blends. Black tobacco still highest-5onglcig. aromatic Schneider, D. 1995 Beitra e zur Tabak. 16 141-156 na hth lamine. amines Review on the changes that occur during flue curing. Most useful sections relate to polyphenolics and to nitrosamine phenols, Peale, D.M. et at 1995 Rec. Advan. Tob. Science 21 81-133 formation. nitrosamines Review on the effect of air curing on burley chemistry. Good summary of alkaloid and nitate data in relation to nitrosamine Wiernik, A. et al 1995 Rec. Advances in Tob. Sci 21 39-81 levels. Micro-or anism role discussed nitrosamines RJR publication on fresh sidestream smoke, HCN and others Cole, S. and Martin, studied using TDL approach. Find higher levels than with P. 1996 Anal st 121 495-500 NDIR. HCN data for 1 R4F SS. HCN Inhalation Toxicol. 9 pp 867-890 (CCTS A review. Selects information (uncritically) to support a Stohs, S. J. ei al 1997 9043) h othesis of metals/ reactive ox en s ecles. metals .... RNF smoke refs. 6/27/00 S6S6L9Z90Z (

DRAFT • Hoffmann, D. and J. Toxicol. and Environmental Health 50 pp Review. Broad scope makes this most useful. Good Hotfmann 1. 1997 307-364 discussion of desi n features and their effects on smoke all on list aromatic Food and Chem. Toxicology 35 pp 1107- Review, previously listed for metals, but much information on arnines, Smith, C. J. et al 1997 1130 aromatic amines and benzene h drocarbon Getahrstoffe-Reinhaltung der 1-uft 57 pp 463- Polish authors foung a relationship between high ash and Baron, J. et al 1997 465 (CCTS 8880) hi her PAH. Difficult to evaluate the validit of the work. PAH Environ. Health Perspect. Suppl. 105 pp 875 Free radical in gas phase and tar theme. Catechol and Pr, or, W. A. 1997 882 CCTS 8831) catechol like substances in tar ma have role in effects. back round J. Chromatog. A 767 pp 163-169 (COTS Method for quantitation of a number of PAH in tar. Values for Gmeiner, G. et al 1997 8814 B[a]P for 1R4F in line with literature (7.9 n/ci t) PAH Anticancer Res. 17 pp 433-437 (COTS Polyphenols in tar, such as catechol, may give rise to active Kodama, M. et al 1997 6800) ox en s ecies. henols A method for both aliphatic and aromatic aldehydes in Chromatographia 44 pp 491-496 (CCTS smoke. Can do MS and SS. Table III has data for a non-filter Kataoka, H. et al 1997 8830) ci arette-60u acrolein in MS, 35u acrolein in 88. acrolein Contains lists of approximate levels of "undesirable" smoke entire Hoffmann and Beitrage zur Tabak.l8 pp 49-52 (CCTS components, with approximate range in smoke for unfiltered Hoffmann Hoffmann 199B 8932) ci aretfes but no references to the ori in of the data) list + others RJR studies on ETS in a well controlled system Many Nelson, P. R. at at 1998 J. Air Waste M mt. Assn. 48 336-344 anal tes, but no mainstream results. Back round info onl back round Bull. Environ. Contam. Toxicol. 60 pp 60-67 Production of aromatic heteroamines (Salmonella mutagens) heteroaroma Kataoka, H. ef al 1998 (COTS 8892) from ci arettes and other sources tic amines Good, recent study of benzene and other semi volatiles in mainstream. Only data for Ref. and British cigts. -44 ug/cigt hydrocarbon benzene for 4R1 F. Also has data for isoprene, acrylonitrile, s, isoprene, Darrall, K. G. et al 1998 Anal st 123 1095-1101 (CCTS 8914 e. . 12.5u /ci acr lonitrile is t ical. acr ionftri)e aza arenes, Stevens, N. A. and Anal. Chem. 71 pp 2179-21 B5 (CCTS Used stable isotope lable to study nicotine distribution in a 3 vinyl Bor erdin , M. 1999 9013 ci arette. Good recent results for 3-vin I pyridine, nicotine ridine Enzymes used to reduce levels of protein in cured bright or burley tobacco, sheets, with or without solubles return. amino Resulted in significant reduction in activity in Ames assay, heteroaroma Cla , W. et at 1999 Mutation Research 446 167-174 TA98. tics A detinitive review, especially useful for drawing together precursors, Smoke Chemistry in Tobacco-Production, informatbn on precursors on a class by class basis. Good smoke Baker, R. R. 1999 Chemistr , and Technolo 398-439 section on nitrosamines, useful MS/SS table etc. formation RNEsmokelefs._6_/27/00 _ i 9696L9Z90Z