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2000 ANNUAL CONFERENCE OF THE ISEE S 103 324 ENVIRONMENTAL TOBACCO SMOKE AND NON-FATAL MYO- CARDIAL INFARCTION AMONG NEVER-SMOKERS MATS ROSENLUND BERGLIND NIKLAS, GUSTAVSSON ANNIKA, REUTERWALL CHRISTINA, HALLQVIST JOHAN, NYBERG FREDRIK, PERSHAGEN GORAN. Department of Environmental Health, Stockholm. EMail: mats.rosenlund0smd.sll.se An increased risk for myocardial infarction (MI) related to environmental tobacco smoke exposure (ETS) has been reported in epidemiological studies, but some aspects of the association are still uncertain- We studied the MI-risk associated with ETS exposure among male and female nonsmokers in a large Swedish population-based case-control study 1992-1994. In par- ticular, we focused on the importance of intensity and duration of exposure, time since lasr exposure, and combined exposure from spouse and work, i.e. the major ETS exposure sources. The study population comprised 334 non-fatal never-smoking MI-cases in the ages of 45-70 years, and 677 population controls matched on age, gender, and hospital catchment area. Fatal cases of MI were excluded due to the lower quality of questionnaire information on ETS and other exposures from next-of-kin. A postal questionnaire provided information on ETS exposure, and a large set of other potential risk factors for Mt, Lncluding physical and psychosocial work environment, social factors, different life- style factors, and diet. After adjustment for the matching variables, body mass index, socioeco- nomic status, jobstrain, hypertension, and diet, the odds ratio for MI was 1.6 (95% Cl 1-0-2-6) among those with an average daily exposure of 20 cigarettes or more from their spouse or cohabitant. Combined exposure from spouse and work showed a consistently increasing odds ratio for MI, up to 1.56 (95% CL 1.0-2.3) in the highest category of weighted duration, i.e. more than 90 hour-years of exposure (1 hour-year=365 hours, or 1 hour/day for one year). In addition, the combined exposure appeared to convey a higher risk for more recent exposure. In conclusion, our data confirm a risk of non-fatal MI from exposure to ETS, and show that intensity of spousal exposure, combined exposure from dif- ferent sources, and time since last exposure might be of special importance.