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1 REPORTS PUBUSHED FROM THE PAPILLOMAVIRUS PROJECT SINCE 1981 A.ORIGINAL ARTICLES, REVIEWS, BOOK CHAPTERS: 1.Syrjfinen, KJ., Heinonen, U-M., and Kauraniemi, T. Cytological evidence of the association of condylomatous lesions with the dysplastic and neoplastic changes in uterine cervix. Acta Cytol. 25, 17- 22, 1981. 2.Syrjfinen, KJ. Ep'dhelial lesions suggestive of a condylomatous origin found closely associated with invasive bronchial squamous cell carcinoma Respiration 40, 150-160, 1980. 3.Syrj&nen, S.M., Syrj9nen, KJ., Lamberg, M.A. and Sainio, P. Focal osteoporotic bone marrow defects of the jaws. Report of a case and survey of the literature. Proc. Finn, dent. Soc. 76, 219-224, 1980. 4.Syrj&nen, KJ. Condylomatous lesions of the uterine cervix with special reference to squamous cell carcinogenesis. Gynecol. Obstet. Invest. 11, 350-364, 1980. S.Syrj&nen, KJ. Bronchial squamous cell carcinomas associated with epithelia] changes identical to condylomatous lesions of the uterine cenrbc. Lung 158, 131-142, 1980. 6.Syrjanen, KJ. and Syrjfinen, S.M. Histological evidence for the presence of condylomatous epithelial lesions in association with laryngeal squamous cell carcinoma ORL, 43, 181-194, 1981. 7.Syrj9nen, KJ. and Syrj9nen, S.M. Premalignant epithelial changes in the uterine cervix of women aged less than thirty with special emphasis on the coexistent condylomatous lesions. Indian J. Dermatol. Venereol. Leprol. 47, 88-97, 1981. 8.Syrj9rten, KJ. Condyiomatous lesions associated with precancerous changes and carcinomas of the uterine cervix Neoplasma 28, 497-509, 1981. 9.Vayrynen, M., Romppanen, T., Koskela, E., Castren, O. and Syrjanen, K Verrucous squamous cell carcinoma of the female genital tract. Report of three cases and survey of the literature. Int J. Gynaecol. 19, 351 -356, 1981. 10.SyrjAnen, KJ. and Pyrh6nen, S. Demonstration of human papilloma virus (HPV) antigen in the condylomatous lesions of the uterine cervix by immunoperoxidase technique. Gynecol. Obstet. Invest. 14, 90-96, 1982. 11.Syrj9nen, KJ. Syrj9nen, S.M. and PyrhBnen, S. Human papilloma virus (HPV) antigens in lesions of laryngeal squamous cell carcinomas. ORL 44, 323-334, 1982. 12.Syrj9nen, KJ. Histological changes identical to those of condylomatous lesions found in esophageal squamous cell carcinomas. Arch. Geschwulstforsch. 52, 283-292, 1982. 13.Syrjanen, KJ., Pyrh6nen, S., SyrjBnen, S.M. and Lamberg, M.A. Immunohistochemical demonstration of human papilloma virus (HPV) antigens in oral squamous cell lesions. Brit. J. Oral Surg. 21, 1 4 7 - 153, 1983. 14.Syrjanen, KJ., Pyrh6nen, S., Aukee, S. and Koskela, E. Squamous cell papilloma of the oesophagus: a tumour probably caused by Human papilloma virus (HPV). Diagn. Histopathol. 5, 291- 296, 1982. 15.Syrj&nen, KJ., Pyrh6nen, S. and SyrjAnen, S.M. Evidence suggesting Human papillomavirus (HPV) etiology for the squamous cell papilloma of the paranasal sinus. Arch. Geschwulstforsch. 53, 77-82, 1983.

2 16.Syrjanen, K, VaLyrynen, M., Castren, 0., MAntyjArvi, R., Pyrhonen, S. and Yliskoski, M. Morphological and immunohistochemical evidence of Human papilloma virus (HPV) involvement in the dysplastic lesions of the uterine cervix. Int. J. Gynaecol. Obstet. 21, 261-269, 1983. 17.SyrjAnen KJ. and Pyrh6nen, S. Immunoperoxidase demonstration of Human papilloma virus (HPV) in dysplastic lesions of the uterine cervbc. Arch. Gynecol. 233, 53-61, 1982. 18.Syrjanen, KJ. Syrjanen, S.M., Lamberg, M.AA and Pyrhonen, S. Human papillomavirus (HPV) invelvement in the squamous cell lesions of the oral cavity. Proc. Finn. dent. Soc. 79, 1-8, 1983. 19.SyrjaLnen, KJ. and Pyrh6nen, S. Demonstration of Human paiiloma virus antigens in a case of urethral condyloma Scand. J. Uroi. Nephrol. 17, 267-270, 1983. 20.SyrjBnen, KJ., Syrj~nen, S.M., Lamberg, M.A. and Happonen, R.P. Local immunological reactivity in oral squamous cell lesions of possible HPV (Human papillomavirus) origin. Arch. Geschwulstforsch. 53, 537-546, 1983. 21.Syrjanen, KJ. Genital papillomavirus infections in the human. In: Infections in Reproductive Health. Vol. II. Uncommon Infections and Special Topics. (Eds.) LG.Keith, G.S. Berger and D.A. Edelman. MTP Press Ltd., Lancaster, England. pp. 155-173, 1985. 22.Syrjfinen, KJ. Human papillomavirus (HPV) lesions in association with cervical dysplasias and neoplasias. Obstet Gynecol. 62, 617-624, 1983. 23.Syrjanen, KJ. Immunocompetent cells in uterine cervical lesions of Human papillomavirus (HPV) origin. Gynecol. Obstet Invest. 16, 327-340, 1983. 24.SyrjAnen, K, Syrjanen, S., Lamberg, M., Pyrh6nen, S. and Nuutinen, J. Morphological and immunohistochemical evidence suggesting Human papillomavirus (HPV) involvement in oral squamous cell carcinogenesis. Int. J. Oral Surg. 12, 418-424, 1984. 25.Syrjanen, K, VAyrynen, M., Castren, 0., Mktyj.W, R. and Yliskoski, M. The relation between the type of immunoreactive cells found in Human papillomavirus (HPV) lesions of the uterine cervix and the subsequent behaviour of these lesions. Arch. Gynecol. 234, 189-196, 1984. 26.Syrjanen, K, VAyrynen, M., Castren, 0., Yliskoski, M., M&ntyj&rvi, R., Pyrh6nen, S. and Saarikoski, S.Sexual behaviour of the females with Human papillomavirus (HPV) lesions in the uterine cervbc. Brit J. vener. Dis. 60, 243-248, 1984. 27.Syrjanen, K, Happonen, R.P., Syrjanen, S, and Calonius, B. Human papillomavirus (HPV) antigens and local immunological reactivity in oral squamous cell tumors and hyperplasias. Scand. J. Dent. Res. 92, 358-370, 1984. 28.Syrj&nen, K, M"j.W, R., Vftyrynen, M., Castren, 0., Yliskoski, M., Saarikoski, S. and Pyrh6nen, S. Herpes simplex virus infection of females with Human papillomavirus (HPV) lesions in the Uterine cervoc. Cervix & Lf.g.t. 2, 25-32, 1984. 29.Syrjanen, S., Syrjanen, K, Ikenberg, H., Gissmann, L and Lamberg, M.A. Human papillomavirus closely related to HPV 13 found in a focal epitheliai hyperplasia lesion (Heck Disease). Arch. Dermatol. Res. 276, 199-200, 1984. 30.Syrjanen, KJ. Current concepts on Human papillomavirus (HPV) infections in the genital tract and their relationship to intraepithelial neoplasia and squamous cell carcinoma Obstet. Gynecol. Surv. 39, 252-265, 1984. 31.Syrjanen, KJ. Ihmisen papilloomavirus (HPV) ja levyepiteelisy8pa. Solubiologi 1, 3-7, 1984.

3 32.Syrjanen, K, Mi3ntyjarvi, R., V&yrynen, M., Castren, 0., Yliskoski, M. and Saarikoski, S. Chlamydial cervicitis in women followed-up for Human papillomavirus (HPV) lesions of the uterine cervoc. Acta Obstet Gynecol. Scand. 64, 467-471, 1985. 33.Syrjanen, KJ. Female genital tract infections by Human papillomavirus (HPV) and their association with intraepithelial neoplasia and squamous cell carcinoma Cervix & I.f.g.t. 2, 103-126, 1984. 34.Vayrynen, M., Syri'anen, K, Castren, 0., Saarikoski, S. and Mantyjarvi, R. Colposcopy in women with Papillomavirus lesions of the uterine cervix. Obstet. Gynecol. 65, 409-415, 1985. 35.Syrjanen, K, Vayrynen, M., Mantyj-W, R., Castren, 0. and Saarikoski, S. Natural killer (NK) cells with HNK-1 phenotype in the cervical biopsies of women followed-up for Human papillomavirus (HPV) lesions. Acta Obstet. Gynecol. Scand. 65, 139-145, 1986. 36.Vayrynen, M., SyrjAnen, K, MantyjArvi, R., Castren, 0. and Saarikoski, S. Immunophenotypes of lymphocytes in prospectiely followed up human papillomavirus lesions of the cervix. Genitourin. Med. 61, 190-196, 1985. 37.Vayrynen, M., Syri'anen, K, M"jarvi, R., Castren, O. and Saarikoski, S. Langerhans cells in Human papillomavirus (HPV) lesions of the uterine cervix identified by the monoclonal antibody OKT-6. InL J. Gynaecol. Obstet 22, 375-383, 1984. 38.Syrj&nen, K, Vayrynen, M., Hippelainen, M., Castren, 0., Saarikoski, S. and M"j&rvi, R. The in situ immunological reactivity and its significance in the clinical behaviour of the cervical Human papillomavirus lesions. Neoplasma 32, 181-190, 1985. 39.SyrjBnen, K, V9yrynen, M., Saan'koski, S., Mi#ntyjArv9, R., Parkkinen, S., Hippelainen, M. and Castren, O. Natural history of cervical Human papillomavirus (HPV) infections based on prospective follow-up. Brit. J. Obstes:. Gynaecol. 92, 1086-1092, 1985. 40.Syrjanen, K, Vayrynen, M., M"jArvi, R., Saarikoski, S. ja Castren, 0. Ihmisen papilloomavirus (HPV) ja kohdunkaulan sy8pa. Duodecim, 101, 959-968, 1985. 41.Syrjanen, KJ. Human papillomavirus (HPV) infections of the female genital tract and their associations with intraepithelial neoplasia and squamous cell carcinoma Pathol. Annu. 21, 53-89, 1986. 42.Syrj3nen, K, de Villiers, E-M., V&yrynen, M., M&ncyjarvi, R., Parkkinen, S., and Castren, 0. Cervical papilomavirus infection progressing to invasive cancer in less than three years. Lancet, i, 510-511, 1985. 43.Syrl'anen, K, Vayrynen, M., Hippelainen, M., Castren, 0., Saarikoski, S. and Mantyji3rvi, R. Electron microscopic assessment of cervical punch biopsies in women followed-up for Human papillomavirus (HPV) lesions. Arch. Geschwulstforsch. 55, 131-138, 1985. 44.Syrj&nen, KJ. and Syrjanen, S.M. Human Papillomavirus (HPV) infections related to cervical intraepithelial neoplasia (VIN) and squamous cell carcinoma of the uterine cervbc. Ann. Clin. Res. 17, 45-56, 1985. 45.Syrji3nen, K, VAyrynen, M., MAntyjArvi, R., Parkkinen, S., Saarikoski, S., Syrji3nen, S. and Castren, 0. Natural history of HPV infections in uterine cenrbc as determined by prospective follow-up. In: Papilloma Viruses: Molecular and Clinical Aspects. (Eds.) P.M. Howley and T.R. Broker. UCLA Symposia on Molecular and Cellular Biology, Alan R. Liss, Inc., New York. New Series, Vol. 32, 31- 45, 1985. 46.Syrjclinen, K, M"jarvi, R., Parkkinen, S., Vayrynen, M., Saarikoski, S., Syrjclinen, S. and Castren, O. Prospective follow-up in assessment of the biological behaviour of cervical HPV-associated dysplastic lesions. Banbury Rep. 21, 167-177, 1986.

4 47.Syrjfinen, K, MAntyj-W, R., Vayrynen, M., Holopainen, H., Saarikoski, S. and Castren, O. Factors influencing the biological behaviour of cenrical Human papillomavirus (HPV) infections in prospectively followed-up women. Arch. Geschwulstforsch. 55, 457-466, 1985. 48.FrAki, J., V=Ainen, N. and Sydanen, K Epidermodysplasia verruciformis esimerkkitautina virusten karsinogeneesistl Duodecim. 102, 36-41, 1986. 49.SyrjaLnen, K, M&ntyj.W, R., Vayrynen, M., Holopainen, H., Saarikoski, S., Syrjanen, S., Parkkinen, S. and Castren, O. Structural protein expression in biological behavior of Human papillomavirus infections in uterine cenrbc. Cervix & Lf.g.t. 3, 249-266, 1985. 50.Syrjfinen, K, Parkkinen, S., M"jMvi, R., Vayrynen, M., Sydanen, S., Holopainen, H., Saarikoski, S. and Castren, O. Human papillomavirus (HPV) type as an important determinant of the natural history of HPV infections in uterine cervix. Eur. J. Epidemiol. 1, 180-187, 1985. 51.Syrjfinen, K, MBrttyjarvi, R., VByrynen, M., Parkkinen, S., Holopainen, H., SyrjaLnen, S., Saarikoski, S. and Castren, O. Coexistent Chlamydial infections related to natural history of Human papillomavirus (HPV) lesions in uterine cervix. Genitourin. Med. 62, 345-351, 1986. 52Syrjgnen, S., Sydanen, K, MBntyjBrvi, R., Parkkinen, S., Vfiyrynen, M., Saarikoski, S. and Castren, O. Human papillomavirus (HPV) DNA sequences demonstrated by in situ DNA hybridization in serial paraffin-embedded cervical biopsies. Arch. Gynecol. 239, 39-48, 1986. 53.Lind, P., Syrl'c'Inen, S., Syrjanen, K, Koppang, H.S. and Aas, E. Local immunoreactivity and Human papillomavirus (HPV) in oral precancer and cancer lesions. Scand. J. Dent. Res. 94, 419-426,1987. 54.Syrj9nen, S.M., von Krogh, G. and Sydanen, K Detection of human papillomavirus DNA in anogenital condylomata in men using in situ DNA hybridization applied to paraffin sections. Genitourin. Med. 63. 32-39, 1987. 55.Syrjanen, K, V&yrynen, M., Mi3ntyj&rvi, R., Holopainen, H., Saarikoski, S., Syrjanen, S., Parkkinen, S. and Castren, O. Electron microscopy in assessment of the biological behavior of Human papillomavirus (HPV) infections in the uterine cervix. Neoplasma 33, 493-506, 1986. 56.Parkkinen, S., M9ntyjfirvi, R., Syrjanen, K and Ranki, M. Detection of Human papillomavirus DNA by the nucleic acid sandwich hybridization method from cervical scraping. J. Med. Virol. 20, 279-288, 1986. 57.Syrj&nen, S.M., Syrji3nen, KJ. and Lamberg, M.A. Detection of Human papillomavirus (HPV) DNA in oral squamous cell lesions using in situ DNA-hybridization applied on paraffin-sections. Oral Surg. 62, 660-667, 1986. 58.SyrjBnen, S. and SyrjaLnen, K An improved in situ DNA hybridization protocol for detection of Human papillomavirus (HPV) DNA sequences in paraffin-embedded sections. J. Virol. Meth. 14, 293- 304,1986. 59.Syrjanen, K, Mantyjarvi, R., VAyrynen, M., Sydanen, S., Parkkinen, S., yliskoski, M., Saarikoski, S. and Castren, O. Human papillomavirus (HPV) infections involved in the neoplastic process of the uterine cervix as established by prospective follow-up of 513 women for two years. Eur. J. Gynaec. Oncol. 8, 5-16, 1987. 60.Syrjanen, KJ., M"ji3rvi, R., Vayrynen, M., SyrjBnen, S., Parkkinen, S., Yliskoski, M., Saarikoski, S., Sarkkinen, H., Nurmi, T. and Castren, O. Assessing the biological potential of Human papillomavirus infections in cervical carcinogenesis. Cancer Cells 5, 281-289, 1987. 61.Syrjfinen, S., Partanen, P. and Sydanen, K Comparison of the in situ DNA hybridization protocols

5 using S-labeled probes and biotin-labeled probes in detection of HPV DNA sequences. Cancer Cells 5, 329-336, 1987. 62SyWen, KJ. Papillomaviruses and Cancer. In: Papillomaviruses and Human Disease. (Eds) K Syrj&nen, L Gissmann, L Koss. Springer Veriag, Berlin, Heidelberg, pp. 468-503, 1987. 63.Syrji3nen, KJ. and Syrjanen, S.M. Immunology of Human Papillomavirus (HPV) infections in the reproductive tract. In: Perspectives in Immunoreproduction: Conception and Contraception. (Eds.) S. Mathur and C.M. Fredericks. Hemisphere Publishing Corporation, Washington, D.C., pp. 319-336, 1988. 64.Syrjanen, KJ. Histopathology, cytology, immunohistochemistry and HPV typing techniques. In: Genital Papilloma Virus Infection: A Survey for the Clinician. (Eds.) G. von Krogh and Eva Rylander. Conpharm AB, Karlstad, Sweden. pp. 33-67, 1989. 65.Syrj&nen, K, M"jarvi, R., VAyrynen, M., Syrj&nen, S., Parkkinen, S., Yliskoski, M., Saarikoski, S. and Castren, O. Evolution of Human papillomavirus (HPV) infections in the uterine cervix during a long- term prospective follow-up. Appl. Pathol. 5, 121-135, 1987. 66.Syri'anen, S., SyrjAnen, K, M"jarvi, R., Collan, Y. and Kmk J. Human papillomavirus DNA in squamous cell carcinomas of the larynx demonstrated by in situ DNA hybridization. Oral 49, 175-186, 1987. 67.SyrjAnen, K and Syrjanen, S. Human papillomavirus DNA in bronchial squamous cell carcinomas. Lancet i, 168-169, 1987. 68.SyrjAnen, KJ. Biology of Human papillomavirus (HPV) infections and their role in squamous cell carcinogenesis. Med. Biol. 65, 21-39, 1987. 69.Syrj&nen, S., Happonen, R-P., Virolainen, E., Siivonen, L and SyrjAnen, K Detection of Human Papillomavirus (HPV) structural antigens and DNA types in nasal inverted papillomas and squamous cell carcinomas of the nasal cavities and paranasal sinuses. Acta Otolaryngol (Stockh) 104, 334-341, 1987. 70.Syrjfinen, KJ. M"jArvi, R., Vi3yrynen, M., Yliskoski, M., Syrjanen, S.M., Seppo Saarikoski, S., Nurmi, T., Parkkinen, S., Castren, O. Cervical PAP smears in assessment of the natural history of cervical Human papillomavirus (HPV) infections in prospectively followed-up women. Acta Cytol. 31, 855-865, 1987. 71.Syrjanen, KJ. Les infections 'a papillomavirus humain (HPV) facteur carcinog'ene possible by carcinoma epidermoide du col uterin. Contraception-Fertilite-Sexualite, 15, 963-973, 1987. 72Syrj9nen, K and Syrjanen, S. Morphological relationship of papillomavirus infections to cervical, vulvar and penile cancer. In. Herpes and Papilloma Viruses, vol II. (eds). G. de palo, F. Rilke and H. zur Hausen. Serono Symposia Publications, Raven Press, Vol 46, 179-198, 1988. 73.Syrjanen, S., Cintorino, M., Armellini, D., Del Vecchio, M.T., Leoncini, P., Bugnoli, M., Pallini, V., Silvestri, S., Tosi, P., M"j&rvi, R. and Syrjanen, K Expression of cytokeratin potypeptides in Human papillomavirus (HPV) lesions of the uterine cenroc I. Relationship to Grade of CIN and HPV Type. Int. J. Gynec. Pathol. 9, 23-38, 1988. 74.Syrjanen, S.M., Syrji3nen, KJ., Happonen, R-P. and Lamberg, M.A. In situ DNA hybridization analysis of Human papillomavirus (HPV) sequences in benign oral mucosal lesions. Arch. Dermatol. Res. 279, 543-549, 1987. 75.Syrjanen, KJ. Virology and pathogenesis. In: Genital Papilloma Virus Infections and Their Sequelae. Proceedings of an international symposium held during the 17th World Congress of Dermatology, Berlin, May 1987. pp. 5-15, 1987.

6 76.von Krogh, G., Syrjanen, S. and Syrj&nen, K Advantage of human papillomavirus typing in the clinical evaluation of genitoanal warts; Experience with the in situ deoxyribonucleic acid hybridization technique applied on paraffin sections. J. Amer. Acad. Dermatol. 18, 495-503, 1988. 77.Tosi, P., Luzi, P., Santopietro, R., Miracco, C., Uo, R., Syd&nen, S., M"jarvi, R. and SyrjBnen, K Morphometric assessment of the biological potential of Human papillomavirus (HPV) infections in the uterine cervix. Appi. Pathol 6, 247-257, 1988. 78.Syrl'8nen, KJ. Human papillomavirus (HPV) infections and their associations with squamous cell neoplasia. Arch. Geschwulstforsch. 57, 417-443, 1987. 79.Parkkinen, S., Syrj&nen, S., Syrj9nen, K, Yliskoski, M., Tenhunen, J., MantyjBrvi, R. and Ranki, M. Screening of premajignant cervical lesions for HPV 16 DNA by sandwich and in situ hybridization techniques. Gynec. Oncol. 30, 251-264, 1988. 80.Cintofino, M., SyrjAnen, S., Leoncini, P., Bellizzi De Marco, E., Petracca, R., pallini, V., Tosi, P., M"j,W, R., and Syrjfinen, K Altered expression of filaggrin in Human papillomavirus (HPV) lesions of the uterine cenvbc. Arch. Gynecol. Obstet. 241, 235-248, 1988. 81.Syrjanen, S., Partanen, P., M"ji3rvi, R. and Syrj&nen, K Sensitvy of in situ hybridization techniques using biotin- and S-labeled Human papillomavirus (HPV) DNA probes. J. Virol. Meth. 19, 225-238, 1988. 82.Syrji3nen, K, MArnyjBrvi, R., Saarikoski, S., Vayrynen, M., SyrjaLnen, S., Parkkinen, S., Yliskoski, M., Saastamoinen, J. and Castren, O. Factors associated with progression of cervical Human papillomavirus (HPV) infections into carcinoma in situ during a long-term prospective follow-up. Brit. J. Obstet. Gynaecol. 95, 1096-1102, 1988. 83.Sorvari, T., Samesto, A. and Syd&nen, K Type IV collagen in the basal membrane of Human papillomavirus (HPV) associated premalignant and malignant squamous cell lesions of the uterine cervbc. Gynec. ObsteL Invest. 26, 324-331, 1988. 84.Syrjanen, KJ. Infectiones de transmision sexual por papillomavirus humano (HPV): Evaluacion de su historia natural y signification clinica. Revista Ibero-Latinoamericana de E.T.S. 1, 7-18, 1987. 85.Syrj&nen, KJ. Genital papillomavirus (HPV) infections: Clinical significance and associations with genital cancer. Anglo-Scandinavian Conference on Sexually Transmitted Diseases. (Eds) J.D. Oriel and M. Waugh. Roy. Soc. Med. Serv. Int. Cong. Symp. Ser. 135, 45-53, 1988. 86.MAntyjW, R., Sarkkinen, H., Parkkinen, S., Ryhanen, A., Karjalainen, H., Syrj&nen, K and Syrjfinen, S. Phenotypic transformation of primary mouse fibroblasts by BPV I DNA. Arch. Virol. 100, 17-25, 1988. 87.M8ntyjArvi, R., Sarkkinen, H., Karjalainen, H., Parkkinen, S., Ryh&nen, A., Syrjanen, K, J&gerroos, H. and Nurmi, T. Tumour-associated antigens in primary mouse fibroblasts induced by transformation with bovine papillomavirus type 1. Exp. Pathol. 35, 25-33, 1988. 88.Undeberg, H., Syd&nen, S., K9rjfi, J. and Syd&nen, K Human papillomavirus (HPV) type 11 DNA in squamous cell carcinomas and pre-existing multiple laryngeal papillomas. Acta Otolaryngol.(Stockh). 107, 141-149, 1989. 89.SyrjBnen, S.M., Syrjanen, KJ., Happonen, R-P. Human papillomavirus (HPV) DNA sequences in oral precancerous lesions and squamous cell carcinoma demonstrated by in situ hybridization. J. Oral Pathol. 17, 273-278, 1988. 90.Syrjanen, K, Syrl'aLnen, S., Kellokoski, J., KfirjA, J. and MftntyjW, R. Human papillomavirus (HPV)

7 type 6 and 16 DNA sequences in bronchial squamous cell carcinomas demonstrated by in situ DNA hybridization. Lung 167, 33-42, 1989. 91.Yliskoski, M., Saarikoski, S., SyWen, K, Syrj&nen, S. and Castren, 0. Cryotherapy and COZ Iaser vaporization in the treatment of Human papillomavirus (HPV) infections in the uterine cervix and vagina Acta Obstet. Gynecol. Scand. 68, 619-625, 1989. 92.M"jArvi, R., Sarkkinen, H., Parkkinen, S., Laatikainen, A., Ryh&nen, A., and Syrj&nen, K Tumorigenicity of primary mouse fibroblasts transformed by bovine papillomavirus type 1. Intervirology 29, 311 -319, 1988. 93.Parkkinen, S., Mentyjervi, R., Syrj9nen, K and Ranki, M. Sandwich hybridization in solution: A rapid method to screen HPV 16 DNA in cervical scrapes. Molec. Cell. Probes. 3, 1-11, 1989. 94.Syrjanen, K ja Syrji#nen, S. Gynekologisten papilloomavirus (HPV)-infektioiden biologinen merkitys ja niiden DNA-diagnostiikka Duodecim 104, 1864-1873, 1988. 95.Syrj&nen, K Human papillomavirus (HPV) lesions of the vulva: Histopathology. In: Patologia Benigna e Maligna della Vulva (eds). A. Cardone and R. piccoli, CIC Edizioni Intemazionali, Roma, pp. 39-47, 1989. 96.Klemi, P.J., Joensuu, H., Syrjenen, S., Syri'Anen, K, Sirvonen, L and Virolalnen, E. Association of DNA aneuploidy ith Human papillomavirus induced malignant transformation of sino-nasal transitional papillomas. otolaryngol. Head Neck Surg. 100, 563-567, 1989. 97.Syrj$nen, K, Sarikoski, S., Vayrynen, M., Syrj&nen, S., Saastamoinen, J. and Castren, 0. Factors associated with the clinical behavior of cervical human papillomavirus infections during a long-term prospective follow-up. The experience of the Kuopio Institute. Cervix & I.f.g.t 7, 131-143, 1989. 98.Kataja, V., Syrjanen, K, M"j&rvi, R., V&yrynen, M., Syrjfinen, S., Saarikoski, S., Parkkinen, S., Yliskoski, M., Salonen, J.T., and Olli Castren. Prospective follow-up of ceniical HPV infections: Life- Table analysis of histopathological, cytological and colposcopic data Eur. J epidemiol. 5, 1-7, 1989. 99.Costa, S., Poggi, M.G., Palmisano, L, Syrjanen, S., Yliskoski, M. Syrj&nen, K Intramuscular #- interPeron treatment of human papillomavirus lesions in the lower female genital tract Cervix & I.f.g.t. 6, 203-212, 1988. 100.Syri'&nen, S., von Krogh, G. and Syrjanen, K Anal condylomas in homosexual or bisexual and heterosexual males. I. Histopathological and virological assessment. Genitourin. Med. 65, 216-224, 1989. 101.SyrjAnen, K HPV in genital squamous cell tumors: Epidemiology and clinical synopsis. In. Proceedings of the International Symposium: Genital Papiliomavirus Infections: Advances in Modem Diagnosis and Therapy. Hamburg, February 3-5, 1989. In press. 102.Syrjanen, K and SyrjAnen, S. Concept on the existence of Human papillomavirus (HPV) DNA in histologically normal squamous ep'ithelium of the genital tract should be re-evaluated. Acta Obstet. Gynec. Scand. 68, 613-617, 1989. 103.Leoncini, P., Petracca, R., Ruggiero, P., Cintorino, M., SyrjAnen, S., MkrtyjW, R. and Syrjanen, K Expression of cytokeratin no. 19 polypeptide in genital papillomavirus lesions. Gynec. Obstet. 29, 59- 66, 1990. 104.Yliskoski, M., Cantell, K, Syrjanen, K and Syrjanen, S. Topical treatment with human leukocyte interferon of HPV 16 infections associated with cervical and vaginal intraepithelial neoplasia Gynecol. Oncol. 36, 353-357, 1990.

8 105.Syrj&nen, K, Hakama, M., Saarikoski, S., V9yrynen, M., Yliskoski, M., Syrj&nen, S., Kataja, V. and Castren, O. Prevalence, incidence and estimated life-time risk of cervical human papillomavirus (HPV) infections in nonselected Finnish female population. Sex. Transm. Dis. 17, 15-19, 1990. 106.M"j&rvi, M., SyrjAnen, S., Kaipiainen, S., M"jarvi, R., Kahlos, T. and Syrjanen, K Detection of human papillomavirus type 11 DNA in a conjunctival squamous cell papilloma by in situ hybridization with biotinylated probes. Acta Ophthalmol. 67, 425-429, 1989. 107.Ji, H., Syrjanen, S., Syrjanen, K, Wu, A. and Chang, F. In situ hybridization analysis of HPV DNA in cervical precancer and cervical cancers from China Arch. Gynecol. Obstet. 247, 21-29, 1990. 108.Fuju, C., Syrj~nen, S., Qiong S., Hongxiu, J., and Syrj~nen, K Human papillomavirus (HPV) DNA in esophageal precancer lesions and squamous cell carcinomas from China Int J. Cancer. 45, 21- 25, 1990. 109.Laatikainen, A., Karjalainen, H., Sarkkinen, H., SyrjAnen, K and M"j&vi, R. Generation of cell- mediated cytotoxicity against bovine papilloma virus-transformed primary mouse cell lines. Cancer Immunol. Immunother. 30, 351-356, 1990. 110.Kataja, V., Syrjanen, K, Syrjanen, S., M9ntyjarvi, R., Yliskoski, M., Saarikoski, S., M"j8rvi, R. and Salonen, J.T. Prospective follow-up of genital HPV infections: Survival analysis of the HPV typing data. Eur. J. Epidemiol. 6, 9-14, 1990. 111.Ji, H., SyrjAnen, S., Matinlompolo, T., Huovinen, K, Fuju, C.and Syrjanen, K Subclinical HPV infections in the lower female genital tract: Histological evaluation and detection of HPV DNA by in situ hybridization with biotinylated probes. Cervix & l.f.g.t 7, 255-266, 1989. 112.Syrji3nen, KJ. Epidemiology of Human papillomavirus (HPV)infections and their associations with genital squamous cell cancer. APMIS. 97, 957-970, 1989. 113.Syrjanen, KJ. Papillomavirus infections, precancers and epidermoid cancers. In: Papillomaviruses in Human Pathology. Recent Progress in Epidermoid Precancers. Ed. J. Monsonego. Serono Symposia Publications 78, 13-29, 1990. 114.Syrjanen, KJ. and Syrj&nen, S.M. Papillomavirus infections, precancers and epidermoid cancers of sinuses, oropharynx, oesophagus and lung.ln: Papillomaviruses in Human Pathology. Recent Progress in Epidermoid Precancers. Ed. J. Monsonego. Serono Symposia Publications 78,315- 329,1990. 115.Fuju, C., SyrjAnen, S., Q Shen., H. Ji, and Syrj~nen, K Detection of Human papillomavirus (HPV) in genital warts and carcinomas by DNA in situ hybridization in Chinese patients. Cytopathol. 1, 97- 103, 1990. 116.Tosi, P., Pallini, V., Cintorino, M., Bugnoli, M., Covacci, A., Petracca, R., Syrj&nen, S., Del Vecchio, M.T., MAntyjarvi, R., Ruggiero, P., Armellini, D. and SyrjAnen, K Use of antibodies against a synthetic peptide of the E6 protein of human papillomavirus (HPV) type 16 for the diagnosis of genital HPV lesions. Cytopathol. In press. 117.Syrj&nen, S., von Krogh, G., Kellokoski, J. and Syrjanen, K Two different papillomavirus (HPV) types associated woth oral mucosal lesions in an HIV-seropositive male. J. Oral. Pathol. Med. 18, 366- 370, 1989. 118.Hellberg, D., Nilsson, S., Gad, A., Hongxiu, J., Fuju, C., Syrj&nen, S. and Syrj&nen, K Long-term behavior of cervical intraepithelial neoplasia (CIN) associated with different Human papillomavirus (HPV) types. Arch. Gynecol. Obstet. In press. 119.Syrjanen, K and Syrj&nen, S. Epidemiology of Human papilloma virus infections and genital

9 neoplasia Scand. J. InfecL Dis. Suppl. 69, 7-17, 1990. 120.Syrjanen, KJ. and Syrjclinen, S.M. DNA hybridization techniques in diagnostic cytopathology. Finska L&karesallskapets Handlingar. 133, 263-271, 1989. 121.Fuju, C., Qiong, S., Jian, Z., Chao, W., Dongyu, W., SyrjaLnen, S. and Syrjenen, K Detection of human papillomavirus (HPV) DNA in cytological specimens derived from esophageal precancer lesions and cancer. Scand. J. Gastroenterol. 25,383-388, 1990. 122Keliokoski, J., SyrjaLnen, S., Syrjanen, K and Yliskoski, M. Oral mucosal changes in women with genital HPV infection. J. Oral Pathol. Med. 19, 142-148, 1990. 123.Kellokoski, J., Syry'anen, S., Kataja, V., Yliskoski, M, and Syrj&nen, K Acetowhfte staining and its significance in diagnosis of oral HPV infection in women with genital HPV infection. J. Oral Pathol. Med. 19, 278-283, 1990. 124.Syrj&nen, KJ. papillomavirus infections- Histology and cytology of genital infections. Proceedings of the 1 st Congress of European Academy of Dermatology and Venereology, Florence, Italy, Sept. 25- 28, 1989. In press. 125.Syrj&nen, S., Saastamoinen, J., Chang, F., Ji, Hx. and Syd&nen, K Coiposcopy, punch biopsy, in situ DNA hybridization and polymerase chain reaction in searching for genital Human papillomavirus (HPV) infections in women with normal PAP smears. J. Med. Virol. 31, 259-266, 1990. 126.Chang, F., Kosunen, 0., Kosma-V-M., Syrjfinen, S., Lahtinen, J. and Syrjclinen, K Verrucous carcinoma of the anus containing Human papillomavirus type 16 DNA detected by in situ hybridization. A case report Genitourin. Med. 66, 342-W, 1990. 127.Costa, S., Terzano, P., Poggi, M.G., Fiorentini, D., Latorre, P., Palmisano, L, Syrjanen, K and Orlandi, C. Interferon (IFN) treatment of human genital papillomavirus lessions with emphasis on HPV type. In: Papillomaviruses in Human Pathology. Recent Progress in Epidermoid Precancers. Ed. J. Monsonego. Serono Symposia Publications 78, 207-215, 1990. 128.Syrj&nen, KJ. Genital Human papillomavirus (HPV) infections and their associations with squamous cell cancer Reapprisal of the morphologic, epidemiologic and DNA data Progr. Surg. Pathol. Invited review. In press. 129.Fuju, C., Syrj&nen, S., Nuutinen, J., K&rjk J. and Syd&nen, K Detection of Human papillornavirus (HPV) DNA in oral squamous cell carcinomas by in situ hybridization and polymerase chain reaction. Arch. Dermatol. Res. 282, 493-497, 1990. 130.Syrjanen, S., Andersson, B., Juntunen, L and Syd&nen, K Use of potymerase chain reaction in generation of biotinylated human papillomavirus DNA probes for in situ hybridization. J. Virol. Meth. 31, 147-160, 1991. 131.Syrj&nen, KJ. Natural history of genital HPV infections. Papillomavirus Rep. 1 (4), 1-5, 1990. 132.SyrjBnen, K, Yliskoski, M., Kataja, V., HippelAinen, M., Syd&nen, S., Saarikoski, S. and Ryhanen, A. Prevalence of genital human papillomavirus (HPV) infections in a mass-screened Finnish female population aged 20-65 years. Int. J. STD & AIDS. 1, 410-415, 1990. 133.Laatikainen, A., Sarkkinen, H., Syrjanen, K and Mantyjervi, R. Local immune reaction in syngeneic mice against tumorigenic and nontumorigenic BPV-transformed mouse cell lines. APMIS 98, 909-915, 1990. 134.Chang, F., Janatuinen, E., Pikkarainen, P., Syd&nen, S. and Syrjenen, K Esophageal squamous

10 cell papillomas. Failure to detect human papillomavirus (HPV) DNA by in situ hybridization and polymerase chain reaction (PCR). Scand. J. Gastroenterol. 26, 535-543, 1991. 135.Ji, HX., SyrjAnen, S., Klemi, P., Chang, F., Tosi, P., Syrjanen, K Prognostic significance of nuclear DNA content and human papillomavirus (HPV) type in invasive cenrical cancer. Polymerase chain reaction (PCR) and flow cytometric analysis. Int J. Gynecol. Cancer. 1, 59-67, 1991. 136.Fuju, C., Syrjsnen, S., Kellokoski, J. and SyrjaLnen, K Human papillomavirus (HPV) infections and their associations with oral disease. J. Oral Pathol. Med. 20, 305-317, 1991. 137.Saastamoinen, J., Syrjanen, K, Syrj&nen, S., and M"jArvi, R. Interferon ointment in genital warts. In: Genital Papillomavirus Infections: Modem Diagnosis and Treatment. Eds. G. Gross, S. Jablonska, H. Pfister, H.E.Stegner. Springer Verlag, pp. 431-432, 1990. 138.Kellokoski, J., Syrji3nen, S., Tosi, P., Cintorino, M., Leoncini, P. and SyrjAnen, K Cytokeratin pattern in normal and HPV infected oral mucosa in women with genital HPV infections. J. Oral Pathol. Med. 20, 26-31, 1991 139.Belli, L, Frazer, I., Hogan, P., Kennedy, L, O'Connor, D., Hersey, P., Law, C., Arseneau, J., Dascal, A., Eiley, S., Ferenczy, A., Mendelson, J., Bouchard, C., Fortier, M., Champoux, F., Roy, M., van de Berg, G.M., Stolz, E., Freeman, K, SyrjAnen, K., Barclay, C., Boland, K, Fauchere, S., Kroon, M., Walker, M., Ryff, J.Ch., Smith, P., Wahl, M., Scott K Recurrent condylomata acuminata treated with recombinant interferon atfa-2a: A multicenter double-blind placebo-controlled clinical trial. JAMA. 265, 2684-2687, 1991 140.Maw, R.D., Disnmore, W., Homer, T., Lawther, H., Rinne, E., Lassus, A., Paavonen, J., Aho, M., Nieminen, P., Vesterinen, E., Tuimala, R.J., Juuakka, T., Saastamoinen, J., Syrj&nen, S.M.,SyrjAnen, K.J., Walker, M., Ryff, J.C., Smith, C., Budde, M., Blackburn, N., Ellmen, J. and Wahl, M. Comparison of interferon alpha-2a and podophyllin in the treatment of primary condylomata acuminata Genitourin. Med. 67, 394-399, 1991. 141.Yliskoski, M., Saarikoski, S. and Syrjanen, K Conization for CIN associated with Human papilloma- virus infection. Arch. Gynecol. Obstet. 249, 59-65, 1991. 142.Yliskoski, M., Tervahauta, A., Saarikoski, S., M"jarvi, R. and SyrjAnen, K Clinical course of cervical Human papillomavirus lesions in relation to coexistent cervical infections. Sex. Transm. Dis. In press. 143.Kataja, V., Syrj&nen, K, Syrjanen, S., MAntyjarvi, R., Yliskoski, M., Saarikoski, S. and Salonen, J.T. Prognostic factors in cervical human papillomavirus (HPV) infections. Sex. Transm. Dis. In press. 144.Ji, HX., Yliskoski, M., Vayrynen, M., Hippelainen, M., SyrjAnen, S., and Syrjanen, K Colposcopic analysis of genital human papillomavirus (HPV) infections during an 8-year prospective follow-up. 1nt J. Gynec. Obstet. 36, 291 -300, 1991. 145.Syrjsnen, S., Andersson, B., Juntunen, L, Syrjsnen, KJ. Potymerase chain reaction for producing biotinylated Human papillomavirus DNA probes for in situ hybridization. Sex. Transm. Dis. In press. 146.Kellokoski, J., Syrjanen, S., Yliskoski, M. and Syrj&nen, K Dot blot hybridization in detection of human papillomavirus (HPV) infections in the oral cavity of women with genital HPV infections. Oral Microbiol. Immunol. 7, 19-23, 1992. 147.HippelAinen, M., Yliskoski, M., Saarikoski, S., Syrjainen, S.and Syrjanen, K Genital human papillomavirus lesions of the male sexual partners: the diagnostic accuracy of peniscopy. Genitourin. Med. 67, 291-296, 1991.