Philip Morris
Draft Talk to Epa Sab
Fields
- Type
- SPCH, SPEECH, PRESENTATION
- PHOT, PHOTOGRAPH
- Attachment
- 2501073503/2501073556
- Area
- LEGAL DEPT/EEMA ARCHIVE
- Site
- E35
- Named Person
- Akiba
- Brownson
- Buffler
- Chan
- Correa
- Gao
- Garfinkel
- Geng
- Hirayama
- Hole
- Humble
- Inoue
- Janerich
- Kabat, G.
- Koo
- Lam
- Lee
- Pershagen
- Shimizu
- Sobue
- Surgeon General
- Svensson
- Trichopoulos
- Varela
- Wells, J.
- Wu
- Brownson
- Request
- Stmn/Rl-002
- Stmn/R1-048
- Document File
- 2501073421/2501073557/Ets General 900000 - 910000 Eema Legal Dpt.
- Named Organization
- 1990 Toxicology Forum
- Epa, Environmental Protection Agency
- Sab
- Epa, Environmental Protection Agency
- Litigation
- Stmn/Produced
- Characteristic
- MARG, MARGINALIA
- Master ID
- 2501073503/3556
Related Documents:- 2501073503
- 2501073504-3528 'health Effects of Passive Smoking: Assessment of Lung Cancer in Adults and Respiratory Disorders in Children' Notes on the Meeting of the US Environmental Protection Agency (Epa) Science Advisory Board (Sab) to Consider the External Review Draft Held at Crystal City, Washington Dc on 901204 and 901205
- 2501073529 U.S. Environmental Protection Agency Science Advisory Board Indoor Air Quality and Total Human Exposure Committee (Iaqthec) Environmental Tobacco Smoke Review
- 2501073530-3532 U.S. Environmental Protection Agency Science Advisory Board Indoor Air Quality and Total Human Exposure Committee Environmental Tobacco Smoke Review Final Draft Agenda
- 2501073533-3535 Science Advisory Board Review of the Draft Report 'health Effects of Passive Smoking: Assessment of Lung Cancer in Adults and Respiratory Disorders in Children.' Epa/600/6-90/006a
- 2501073556 Passive Smoke A Cause of Cancer, Panel Concludes Epa Told Risk of Respiratory Illness in Children Also Increased by Involuntary Exposure
- Date Loaded
- 05 Jun 1998
- UCSF Legacy ID
- ewu32e00
Document Images
USE CONSISTENT EXPOSURE INDEX
Among women who have never smoked
Compare
1. Husbands who have NEVER smoked
2. Husbands who have EVER smoked
Relevant to Hirayama
Trichopoulos
Garfinkel (case-control)
9tisELoxosz
'--, ~
` -_
LUNG CANCER
AND ETS EXPOSURE
AT WORK
Garfinkel 1I* Female 0.88 (0.66 - 1.18)
0.93 (0.73 - 1.18)
Kabat I Female 0.68 (0.32 - 1.47)
Male 3.27 (1.01 - 10.6)
Kabat II Female 1.00 (0.49 - 2.06)
Male 0.98 (0.46 - 2.10)
Lee Female 0.63 (0.17 - 2.33)
Male 1.61 (0.39 - 6.60)
Shimizu Female 1.20 (0.44 - 1.37)
Varela** Both 0.91 (0.80 - 1.04)
Wu Female 1.30 (0.50 - 3.30)
-LVS6L0T0S3 *Exposure in last 5 years and in last 25 years
**Per 150 person/years smoking in the workplace
LUNG CANCER
AND ETS EXPOSURE
IN CHILDHOOD
Akiba Combined Parents "No association"
Correa Combined Parents "No sig increase"
Gao Female Cohabitant 1.10 (0.70 - 1.70)
Garfinkel II Female Any 0.91 (0.74 - 1.12)
Kabat II Female Family 1.68 (0.86 - 3.27)
Male 0.73 (0.34 - 1.59)
Koo Female Household 0.55 (0.16 - 1.77)
Pershagen Female Parents 1.00 (0.40 - 2.30)
Sobue Female Father 0.60 (0.40 - 0.91)
Mother 1.71 (0.95 - 3.10)
Other family 1.13 (0.69 - 1.87)
Svensson Female Father 0.90 (0.40 - 2.30)
Mother 3.30 (0.50 - 18.8)
Varela Combined Household 1.30 (0.85 - 2.00)
Wu Female Parents 0.60 (0.20 - 1.70)
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LUNG CANCER RELATIVE RISK
FOR SPOUSE SMOKING
FEMALES
Studies with obvious failure to compare like with like
are highlighted
Inoue 2.55 Koo 1.55 Shimizu 1.08
Humble I ~ 2.34 Aki ba 1.52 Lee 1.03
Geng 2.16 Hirayama 1.38 Pershagen 1.03
Trichopoulos ~ 2.08 Svensson ~ 1.26 Sobue 0.94
Correa ~ 2
07.
. Buffler 0.80
Lam I ~ 2.01 Garfinkel II 1.23 Kabat II 0.90
Hole 1.89 Wu 1.20 Kabat I 0.79
Brownson x 1.82 Gao 1.19 Chan 0.75
Lam il ~- 1.65 Garfinkel 1 1.17 Varela x~ 0.75
6VSEL0t0SZ
SOURCES OF BIAS
(SAB issue v)
o Failure to compare like
with like
o Publication bias
o Confounding
o Misclassification of active
smoking status
SPOUSE SMOKING AND LUNG CANCER
EVIDENCE OF PUBLICATION BIAS
IN STUDIES ON FEMALES
8 Studies with highest relative risk estimates (>1.80)
Numbers of lung cancers 6, 19, 20, 22, 22, 54, 60, 77
mean 35 median 22
8 studies with lowest relative risk estimates (<1.05)
Numbers of lung cancers 24, 32, 41, 53, 70, 84, 120, 144
mean 71 median 61.5
(p<0.05)
t956Lotosz
MISCLASSIFICATION OF
ACTIVE SMOKING STATUS
o Misclassification as NEVER smokers
o Misclassification as a proportion
of EVER smokers
o Adjust study by study
0 Use parameters relevant to study
ZSSELOtQSZ
BIAS FROM MISCLASSIFICATION
IN FOUR SCENARIOS
Scenario % Ever
Smoked % ETS
Exposed RR
Smoking Misciass
Rate
Bias *
US women 49.0 54.3 6.73 1°l0 1.06
2 °/0 1.12
5 °l0 1.35
10% 2.02
US men 77.1 38.7 11.83 1% 1.52
2 °l0 2.38
Asian women 24.5 56.9 2.99 10% 1.07
25% 1.26
40 °l0 1.73
50 °/0 2.82
Asian men 80.8 6.6 3.48 1 °/0 1.20
2% 1.42
5% 2.36
essscoiosz
* Assuming concordance ratio of 3.0
INCLUDE ASIAN EVIDENCE?
(SAB issue iii)
Highly dubious because:
0 Extent of exposure may differ
0 No Asian misclassification data
0 Objective to provide US estimate
tiSSEL0t0Sz
CHARACTERIZE UNCERTAINTIES
(SAB issue vi)
0 US vs All
0 Ex-smokers
0 Dosimetric vs Epidemiological
sssECOiosZ
