Philip Morris
Expression of P53 and C-Myc in Mouse Lung Cancer Induced by Coal Burning
Fields
- Author
- Dai, X.
- Lin, C.
- Shi, Y.
- Song, L.
- Sun, X.
- Lin, C.
- Characteristic
- EXTR, EXTRA
- Master ID
- 2081782960/3432
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- Type
- ABST, ABSTRACT
- SCRT, REPORT, SCIENTIFIC
- Site
- R100
- Litigation
- Mile/Produced
- Author (Organization)
- Heilongjiang Cancer Research Inst
- Area
- CENTRAL FILES/STORED FILES
- Date Loaded
- 05 Mar 2003
- UCSF Legacy ID
- spw81c00
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EXPRESSION OF P53 AND C-MYC IN MOUSE LUNG CANCER INDUCED
BY COAL BURNING
Lin Chun-van, Dai Xu-dong, Song Lan-ying,
Shi Yu-bo and Sun Xi-wen
Heilongjiang Cancer Research Institute, Harbin, China
Previous epidemiological studies have reported an association between coal burning and human
lung cancer. To confirm the relationship between coal burning and lung cancer initiation and
progression, the expression of p53 and c-myc in mouse lung cancer induced by burning coal smoke was
studied by in-situ hybridization techniques (ISH). A total of 240 mice were divided into four groups
according to the weight of burning coal (160g, 105g, 60g and control) and were exposed to burning
coal
for sixty minutes/day for two years. The lung cancers induced were all adenocarcinomas. The
incidence
of lung cancer was 9/37 (24.3%) in the "160g-coal" group, 6/47 (12.8°l) in the "105g-coal" group,
5/53
(9.4%) in the "60g-coal" group, and 2/52 (3.6%) in the "control" group. Thirteen samples with
obvious
signs of cancer in adjacent tissues were taken from the experimental groups. Five lung tissue
samples
were obtained from the controls. The tissues were fixed with formalin and processed in paraffin wax.
Samples were all analyzed for the expression of c-myc and p53 by ISH, using a biotin-labeled probe.
Specifically, tissue sections were digested with proteinase K. DNA-RNA hybrids were demonstrated
with
an alkaline phosphatase streptavidin conjugate nitroblue tetrazolium (NBT) detection system. There
was
an over-expression of p53 mRNA in all 13 lung cancer samples and in 5 of the adjacent tissue
samples.
Likewise, c-myc was found to be over-expressed in 9 lung cancer samples and in 1 adjacent tissue
sample. By contrast, no expression of p53 and c-myc in control samples was detected. Thus, a
significant difference in the expression of c-myc gene (P= 0.002) and p53 gene (P =0.001) was found
between the experimental group and the controls.
The data confirm that over-expression of p53 and c-myc are common molecular events of lung
cancer induced by burning coal and provide further evidence that burning coal is a risk factor for
lung
cancer.
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