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Michael W. Ogden, Ph.D. R. J. Reynolds Tobacco Co. Tobacco Company Research & Development P.O. Box 1236 Winston-Salem, NC 27102-1236 Telephone: 910-741-5787 Facsimile: 910-741-5019 E-mail: ogdenm@rjrt.com October 2, 1997 MINUTES OF CORESTA'S ETS SUB-GROUP MEETING Hamburg, Germany September 11, 1997 Attendees: Gunnar Anderson, Jan Arnarp, Takuya Asai, Ian Bailey, Hoy Bohanon, Barrie Frost, Evan Gregg, Jurgen Hollweg, Keon Joong Hwang, Michael Intorp, Isao Ishii, Shinichi Kanematsu, Michael Ogden, Rolf Olsen, Jean-Jacques Piade, Stephen Purkis, Moon Soo Rhee, Yves Saint-.Taim, Joaquin Sarabia, Gerhard Scherer, Matthias Schorp Introduction Mike OGDEN welcomed participants to the half-day meeting. The 21 Sub-Group members present signed the attendance list and received the agenda (attached as Appendix 1). Ventilation Study Progress For the restaurant indoor air quality survey, the participants discussed the next steps in completing their final report on the survey of 34 restaurants which has been conducted in six countries. The next steps involve data analysis, conclusions, and drafting of the final report. By November, there should be a draft of the following sections of the report for study participants to review: (1) Chemical methods - J-J PIADE; (2) Questionnaires - Matthias SCHORP; (3) Ventilation - Hoy BOHANON; (4) Observational Data - Hoy BOHANON; (5) Protocol - Yves SAINT-JALM. The objective is to have the final report completed by June, 1998. As an aid to the laboratories participating in the collaborative study, J-J PIADE agreed to look at some measures of within-lab variability for the chemical analytes determined in the restaurant study as an aid to identifying potential areas of improvement for any given analyte in any given lab. Collaborative Study Progress The list of participating laboratories was reviewed and all lab representati-v"es present indicated their continued willingness to participate. All labs were reminded that the proposed methods under study had been sent out in October, 1996 and the study could not proceed until all labs indicated their readiness. Mike OGDEN asked that all labs try to become ready for analysis by the end of October, 1997 and indicate their status to him in a letter by that time. Several technical details of the study design which were discussed at the spring meeting in Paris were revisited and the following resolutions were reached. (1) XAD tubes - the XAD tube:that will be used for collecting nicotine and 3-EP is the new tube described in Paris (one section of XAD-4 resin in a 6- mm od glass tube; part no. S2-0361 from SKC, Inc.). (2) Definition of RSP (respirable suspended particles) - the previously described filter (Fluoropore PTFE 1-µm pore size, 37-mm diameter) will be

used along with a cyclone which gives a mass median diameter cut-point of 4 p.m. (See later section for more discussion on the RSP definition.) (3) Sample collection - all samples will be collected in the RJR environmental chambers in Winston-Salem. Participants will only be responsible for sending the necessary sampling materials to Mike OGDEN in advance of the final collaborative experiments and for the laboratory analysis. On this latter point, Michael INTORP made a presentation to the group outlining his understanding of acceptable sampling procedures within ISO and the VDI. His conclusions were that (1) it would be desirable to have all participants collect their own samples but that (2) it was recognized that the performance of joint experiments was dependent on the practicality of technical and financial concerns. It was the agreement of the Sub-Group that involving all laboratories in the sample collection phase of the collaborative study would be technically and financially impractical, and that the originally-devised experimental plan should be acceptable to ISO. Definition of RSP In a continuation of the discussion held in Paris, there was discussion around what the definition of "respirable" should be in the context of respirable suspended particles (RSP). Two issues were discussed: (1) should the particle size collection definition conform to the "respirable" convention (or to some other convention such as "thoracic" or "inhalable" or "high-risk respirable"; and (2) if the "respirable" convention is used, what should the median cut-point diameter be. Mike OGDEN presented a summary of "RSP and Other Particle Size Definitions in Member Countries of the CORESTA ETS Sub-Group" which was based on information collected by the following volunteers: Korea (Moon Soo RHEE); Germany (Gerhard SCHERER); Switzerland (Matthias SCHORP); UK (Barrie FROST); USA (Katherine MAIOLO); Sweden (Jan ARNARP); Japan (Takuya ASAI); France (Yves SAINT-JALM); and Spain (Joaquin SARABIA). Most of the countries surveyed had adopted particle size definitions for indoor andlor workplace air that are compatible with the ISO definition of "respirable"; i.e., median particle size diameter cut-point of 4 lcm. Therefore, the Sub-Group agreed to proceed with the originally-proposed definition of particles as "respirable". The sample collection systems that will be used in the collaborative experiments are compatible with the ISO definition of "respirable". Next Meeting It was agreed that the next full meeting of the Sub-Group would be held in the spring of 1998 in Europe. In the absence of any invitations received from prospective hosts before the end of the year, a meeting will be arranged on a "cost sharing" basis (similar to the 1996 meeting in Milan). Tentative dates are currently either the Ist or 2nd week of May, 1998. Details of the meeting place and time will be mailed to Sub-Group members in advance of that meeting. Respectfully submitted, Michael W. Ogden, Convenor r'.) ~ Q' ON co o~ Ul N 1

! AGEIVDA CORESTA ETS SUB-GROUP MEETING September 11, 1997 Kempinski Atlantic Hotel Hamburg, Germany Thursday, September 11 14: 30 - Sub-group Meeting 1. Welcome 2. Sub-group business 3. Discussion of ventilation study progress and next steps 4. Discussion of collaborative study progress and next steps 5. Review of information gathered on definition of RSP 6. New business 7. Date and place of next meeting -18: 00 -Adjourn