Tobacco Documents Online

31/10 14:52 ~+49 2203 303362 INBIFO Koeln ~ FTR S&T 15.8ep.94 KHO/MWO X:\MWO\MISC\GLANTKHO.DOC PAGE 1 Stanton Glantz Claims "Heart disease is actually a much more important endpolnt of passive smoking than lung cancer and causes 30,000 to 60,000 heart disease deaths annuai/y."~p'z~ < ~ and "The American Heart Association has concluded that ETS is a major risk factor for heart disease In both adults and children." Comment: The role of passive smoking in causing coronary heart disease turns out different in different epidemiological studies. Some studies show that the risk related to smoking almost disappears when correcting for the intake of alcohol (Rylander, t 994; Renaud et el., 1993). Should this be generally true, the biological plausibility of a relation between ETS and cardiac disease is nil, and certainly passive smoking cannot be causative for 30,000 to 60,000 heart diseases annually in the US. R~ferences: Rylander, R., Passive smoking at work as a risk factor for coronary heart disease in Chinese women who have never smoked, Letter to the editors (He Y., I.am, T.H., U, L.S., Du, R.Y., Jia, G.L., Huang, J.Y., Zheng, J.S.) Renaud, S., de Lorgedl, M., The French.paradox: Dietary factors and cigarette smoking-related health risks, in Tobacco smoking and nutrition Diana, J.N., Pryor, W.A. (ads). Annals New York Academy Sci 231,299-309, 1993

~i/I0 '97 14:S~ ~+49 220~ ~0~2 INBIFO Koeln ~ FTR S&T 15,8ep,94 KHO/MWO X:\MWO\MISC\GLANTKHO.DOC PAGE 2 'q'he existence of short-term effects of passive smoking on the cardiovascular system greatly strengthens the evidence that passive smoking causes heart diseases." ~ c,~ z Comment; The reported short-term effects of passive smoking on the cardiovascular system were observed to be followed by a quick recovery (Sinzinger p,t el., 1989). The thrombotic risk for smokers, however, develops gradually over tim~.. Therefore the relevance of short,term reversible changes for the long-term cardiovascular risk remains que.~tienable. aeferenoe: Sinz[nger, H., Virgolinl, !., Besitzen Passivraucher ein erh6htes Thrombo~erisiko?, Wiener kiln Wochenschrift, 101,20, 694-698, 1989

'~'+49 2203 .303362 INBIFO Koeln ~ FTR $&T KHO/MWO X:\MWO\MISC\GLANTKHO.DOC PAGE[ 3 "The body normafly extracts more than 90 % of the oxygen from the blood during exercise, so even small reductions in the efficiency of the oxygen transport system can effect exercising in nonsmokers."~ p o ~ ~ ~ /) Comment: Oxygen extraction from the blood is different at different orcjans and depends on the kind and intensity of the workload (Silbernacjel et al., 1979), Thus the claim that normally 90 % of the oxygen will be extracted from the blood during exercise depends on the definition of the n~grmal intensity, of exercising, Silbernagel, $., Despopoulos, A., Taschenatlas der Physiolo0ie, Georg Thieme Vedag, Stuttgart, 1979