Philip Morris
Environmental Tobacco Smoke and Lung Cancer Mortality in the American Cancer Society's Cancer Prevention Study II
Fields
- Type
- SCRT, REPORT, SCIENTIFIC
- BIBL, BIBLIOGRAPHY
- CHAR, CHART, GRAPH, TABLE, MAPS
- FOOT, FOOTNOTES
- QUES, QUESTIONNAIRE
- BIBL, BIBLIOGRAPHY
- Area
- CARCHMAN,RICHARD/OFFICE
- Characteristic
- MARG, MARGINALIA
- MISS, MISSING PAGES
- OVER, OVER SIZE DOCUMENT
- MISS, MISSING PAGES
- Named Organization
- Acta Oncol
- Aje
- Ajph
- American Cancer Society
- Bjc
- Bmj
- Can Epid Blom Prev
- Can Res
- Cancer
- Epa, Environmental Protection Agency
- Gan No Rinsho
- Hhs, Dept of Health and Human Services
- Iarc
- Ijc
- Ije
- Jnci
- Lancet
- Natl Center for Health Statistics
- Natl Death Index
- Natl Research Council
- NCI, Natl Cancer Inst
- Smoking + Health
- Tncs
- Toh J Exp Med
- Toxicology Forum
- Ucla
- US Census
- Who, World Health Org
- Aje
- Named Person
- Akiba
- Breslow
- Brownson
- Brownsonet
- Buffler
- Butler
- Calle
- Chang
- Cheng
- Correa
- Cox
- Dahlager
- Dalager
- Fielding
- Fontham
- Friedman
- Fung
- Gann
- Gao
- Garfinkel
- Geng
- Greenland
- Grundmann
- Haenszel
- Hirayama
- Hole
- Humble
- Inoue
- Janerich
- Kabat
- Kalandidi
- Kaplan
- Katada
- Kilburn
- Kleinbaum
- Koo
- Lam
- Lee
- Liu
- Mantel
- Meier
- Mizzell
- Percy
- Pershagen
- Rothman
- Selikoff
- Shimizu
- Sobue
- Steenland
- Stockwell
- Surgeon General
- Susser
- Svensson
- Trichopoulos
- Wu
- Wuwilliams
- Wynder
- Breslow
- Master ID
- 2063620519/0720
Related Documents: - Litigation
- Iwoh/Produced
- Site
- R530
- Date Loaded
- 07 Jun 1999
Document Images
Table 11. Age-adjusted prevalence* of current, former, and
never cigarette smoking, CPS II and NHIS-83
Current Former Never
CPS H HIS CPS HIS CPS HIS
II H
Men
White 30.1 31.1 44.4 43.5 25.5 25.4
Black 42.5 41.8 31.6 32.1 25.9 26. i
Women
White 20.4 26.0 22.5 19.7 57.1 54.3
Black 26.2 27.4 I5.8 14.4 58.0 58.2
*(Percent). Standard population: CPS H
62
I
i
I
I
I
I
I
I
I
I
I
I
I
I
I
I
I

I
I
I-
I
I
I
I
I
I
I
I
I
I
I
I
I
I
I
63
Chapter 5: Validity and Completeness
Information
I
On the Outcome Variable
i. Follow-up Procedures
of the
A validation study of the CPs II automated follow-up procedure has been
conducted previously using the National Death Index (ND1) (Calle, 1993). In a
linkage of over 15,000 persons whose vital status through 1988 had been traced
through manual follow-up, 4,686 out of 5,046 (or 92.9 percent) of all deaths
known to ACS volunteers were identified by the National Death Index. Since
the use of automated foliow-up in CPS rr started in 1988, when there were 340
deaths from lung cancer ascertained by volunteers, another 22 have been
ascertained by the use of the NDI. At a false-negative rate of 7% for the
automated procedure, less thad two deaths would have been missed in our study
(i.e. 0.07"22=1.54), by using the automated procedure instead of ascertaining
deaths by ACS volunteers . As noted earlier, follow-up of vital status is
complete for 99.8 % of all enrolled subjects, and of those 101,541 deceased
subjects only 3,258 (3.2%) did not have a death certificate (ACS: Update of the
CPS-II Master Index Vital Status report, April 12, 1993).
ii. Results of Validation Study of Death Certificate Diagnoses of
Lung Cancer '~
For 30 deaths for which lung cancer was considered the underlying cause of
death in CPS II nonsmoking participants who resided in SEER registry areas,
SEER diagnosis was compardd with the underlying cause of death on death
certificates.
In 29 subjects classified as primary lung cancer by death certificates, SEER
Cancer Registries also diagnosed primary lung cancer in 27, and for two, the
primary site was listed unknown in the SEER database. For no cases was the

disease known to be metastatic from other sites to the lung. I.n 25 of these 29
I
lung cancers (86.2 percent), the specific histologic type was known to the SEER
Cancer Registries, and in 64 percent they were adenocarcinomas.
From this small validation study we conclude that lung cancers coded from death
certificates generally correctly classify deaths fro~ primary lung cancer. The
confirmation rate was 93. I percent (27/29), similar to that found in the TNCS
study (Percy I981). Even in the two instances in our validation study in which
the primary site of cancer was unknown, the diagnosis of lung cancer was not
ruled out.
Main Exposure Variables
i. Self Reported ETS Exposure in CPS II and NI=IIS
As mentioned above, because the CPS II questionnaires did not require
respondents to complete all fields, many questionnaires contained blanks (Table
12). Twenty-three percent of the questionnaires filled by men and thirteen
percent of those f'Llled by women were left blank in the three spaces provided for
self-reported number of hours exposed to ETS (i.e., at home, work and other
places). Table 13 displays in detail the patterns of answers from CPS II
enrollees to the questions: " Whether or not you smoke, on the average, how
many hours a day are you exposed to cigarette smoke of others? At home?
(hours); At work (hours); In other areas? (hours)". As shown in this table,
most times a space was left blank when valid answers were provided for at least
one of the three environments.
0
0~
0'~
0
0'~
0
I
I
I
I
I
I
I
I
I
I
I
I
I
i
I
I

I
I
I
65
I
I
I
I
I
I
I
I
I
I
I
I
I
I
Table 12. Answers to question in CPS II on reported hours
of ETS exposure at different settings
a. All Men in CPS II
Hours Home % Work % Other %
Places
0 196,031 38.5 I24,114 24.4 101,533 20.0
I I5,107 3.0 52,856 10.4 71,040 14.0
2 12,258 2.4 24,834 4.9 26,533 5.2
3 8,649 1.71 9,089 1.8 6,979 1.4
4 18,363 3.6 13,359 2.6 6,240 1.2
5 8,678 1.7 5,059 1.0 1,714 0.3
6 11,904 2.3 8,527 1.7 1,384 0.3
7 2,621 0.51 3,985 0.8 280 0.1
8+ 37,827 7.4 80,478 15.8 4,710 0.9
Blank 180,924 35.6 163,357 32. i 261,885 51.5
Unclass 16,232 3.2 22,936 4.5 26,296 5.2
Total 508,594 100.(~ 508,594 100.0 508,594 100.0
All three fields left blank 65,999 (13.0%)
All three fields with unclassifiabIe data 5,006 (1.0%)
~0
0
O~
0~
0
I

66
I
I
I
I
b. All Women in CPS II
'i:Iours Home % Work -% Other % '
Places
0 208,404 30.8 [54,373 22.8 99,953 14.8
1 16,103 2.4 40,117 5.9 46,088 6.8
2 14,029 2. I 16,636 2.5 20,148 3.0
3 10,952 1.6 6,243 0.9 7,06 [ 1.0
4 20,430 3.0 8,937 1.3 4,726 0.7
5 13,642 2.0 4,766 0.7 1,385 0.2
6 15,753 2.3 7,204 1.1 928 0.1
7 4,097 0.6 6,630 1.0 181 0.0
8+ 59,412 8.8 59,133 8.7 4,393 0.6
Blank 282,326 41.7 345,165 51.0 433,178 64.0
Unclass 31,382 4.6 27,326 4.0 58,489 8.6
Total 676,530 100.0 676,530 i00.0 676,530 100.0 .
All three fields left blank 156,249 (23.1%)
All three fields with unclass data 6,285 (0.9%)
0
0
0
I
I
I
I
I
I
i
I
I

!
I
I
I-
I
I
I
I
I
I
I
I
I
I
I
I
I
I
I
Table 13. Patterns of answers given by CPS [I participants to self-
assessment
of number of hours exposed,, to ETS
~.i.~ Men w~m~fi -' '
Home Work Other
hours hours hours ,
• 65,999
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
I to
1 to
1 to
1 to
1 to
I to
0 5,732
1 to 8' 26,097
9 * 8,993
0 l 4,422
0 0 186
0 1 to 8 130
0 9 30
1 to 8 50,206
1 to 8 0 319
I to 8 1 to 8 7,361
I to 8 9 373
9 . 9,208
9 0 25
9 1 to 8 110
9 9 1,733
7,704
0 2,334
1 to 8 2,216
9 431
11,190
65,314
28,323
4,791
1 21,994
1 19,818
I 28,225
1 1,284
654
522
299
932
31,703
0 145
1 to 8 5,311
9 167
0 2,244
0 0 4,146
0
0 0
0 I to8
0 9
to 8
to 8 0
to 8 I to 8
to 8 9
9
9 0
9 Ito8
9 9
12.98 156,249 23.10
l. 13 8,565 1.27
5.13 24,543 3.63
1.77 22,486 3.32
0.87 5,434 0.80
0.04 173 0.03
0.03 100 0.01
0.01 80 0.01
9.87 47,135 6.97
0.06 186 0.03
1.45 4,265 0.63
0.07 745 O. I 1
1.81 9,946 1.47
0.00 18 0.00
0.02 l I9 0.02
0.34 2,282 0.34
1.51 18,908 2.79
0.46 4,372 0.65
0.44 3,743 0.55
0.08 2,613 0.39
2.20 27,148 4.01
12.84 72,162 I0.67
5.57 22,997 3.40
0.94 13,632 2.01
4.32 19,751 2.92
3.90 8,292 1.23
5.55 10,249 1.51
0.25 1,871 0.28
0.13 841 0.12
O. 10 354 0.05
0.06 265 0.04
0.18 1,206 0.18
6.23 77,326 11.43
0.03 142 0.02
1.04 6,890 1.02
0.03 876 O. 13
0.44 5,009 0.74
0.82 4,022 0.59
67
o
o~
0~
0~
o
o~
o

68
I
I to 8 0 1 to 8 3,050 0.60 2,810 0.42
1 to 8 0 9 174 0.03 505 0.07
1 to 8 1 to 8 . 46,980 9.24 44,622 6.60
1 to 8 1 to 8 0 2,897 0.57 1,518 0.22
i to 8 1 to 8 1 to 8 17,191 3.38 8,415 1.24
1 to 8 1 to 8 9 791 0.16 1,316 0.19
1 to 8 9 . 206 0.04 432 0.06
1 to 8 9 0 t7 0.00 19 0.00
1 to 8 9 1 to 8 123 0.02 96 0.01
1 to 8 9 9 262 0.05 420 0.06
9 . 5,362 1.05 14,569 2.15
9 0 15 0.00 15 0.00
9 1 to 8 69 0.01 133 0.02
9 . 9 1,079 0.21 3,735 0.55
9 0 37 0.01 71 0.01
9 0 0 27 0.01 76 0.01
9 0 1 to 8 11 0.00 23 0.130
9 0 9 39 0.01 131 0.02
9 1 to 8 390 0.08 922 0.14
9 1 to 8 0 I0 0.00 II 0.00
9 1 to 8 I to 8 137 0.03 62 0.01
9 I to 8 9 211 0.04 306 0.05
9 9 3,586 0.71 4,815 0.71
9 9 0 26 0.01 28 0.00
9 9 1 to 8 227 0.04 200 0.03
9 9 9 5,006 0.98 6,285 0.93
Total 508,594 100.130 676,530 100.00
*a 9 code means that unquantifiable answ~rs(~vor~g like a ,,10t,,or "little"),
as well as question marks, were answered.
The comparisons of CPS-II data on ETS exposure at home, with data from the
1988 National Health Interview Survey (NCHS NHIS 1988) is presented in
table 14, stratified by age, race and gender. If spaces left blank for number of
hours exposed to ETS at home in CPS II are considered.to represent zero hours
(i.e., unexposed), and persons with "unclassifiable" ETS information are
excluded, then the prevalence figures from self reported data on ETS exposure at
home in CPS rr resemble the prevalence in NHIS. Indeed, all age-adjusted
comparisons of gender and racial specific prevalence figures agree within 3.3
percent. The category of "unclassifiable" ETS represent vague wording (e.g., a
question mark, 'Iittle') that could not be converted into hours during coding of
questionnaires. We concluded that when self-reported ETS exposure in CPS II
o
0~
o
0~
o
o~
I
I
I
,|

I
I-
I
I
I
I
I
I
I
I
I
I
I
I
I
I
69
I
was left blank, persons should be considered unexposed, and that
"unclassifiable" data on ETS exposure in the three blanks should be excluded
from the analyses.
Table 14. Percentage of nons~aokers reportedly exposed to ETS at
home* in CPS II ** and NI:IIS *** by age, race and gender.
White Men Black Men White Black
Women Women
Age CPS NI-IIS :kDiff CPS NHISI :k CPS NHIS :k CPS NHIS _.+
lI lI Diff lI Diff II
Diff
30-34 12.8 10.2 2.6 12.9 II.6 1.3 21.2 15.9 5.3 22.9 21.8
1.I
35-39 10.5 9.2 1.3 12.7 I2.4 0.3 I9.9 14.9 5.0 20.1 18.1
2.0
40-44 8.7 7.7
45-49 9.1 7.3
t.0 t4.4 9.4 1 5.0
1.8 9.6 18.1 -8.5
19.3 15.3 4.0 22.4 20.7 1.7
18.9 17.6 1.3 21.1 18.4 2.7
50-54 8.7 15.5 -6.8 I1.0 14.2 -3.2 18.3 18.6 -0.3 19.4 30.0
-10.6
55-59 8.3 14.4 -6.1 12.0 17.9 -5.9 16.4 11.5 4.9 17.1 22.8
-5.7
60-64 7.3 11.4 -4.1 10.3 25.01 -14.7 13.1 13.0 0.1 15.5 24.0
-8.5
65+ 5.2 5.9 -0.7 5.4 12.0 -6.6 8.4 7.2 1.2 11.7 11.7 0.0
Total 7.8 9.4 -1.6 9.9 13.4 -3.5 14.7 12.8 1.9 17.0 19.2
-2.2
8.8§ 9.8 -t.0 t0.9 14.2 -3.3 15.8 13.2 2.6 18.5 19.9 -t.4
ETS exposure as self-repoSed'- ~umb~ oi"h~'~'~f'~xt~osurc to ETS at home in CPS IL m~d as
living with a smoking person who smokc~ at home in NHIS.
** Excludes "unelassifiable" ETS exposure at home. Considers I-8 hours as exposed, and blanks
in spaces provided to write ETS exposure at home, as well as O's as unexposed.
*** Weighted percentages (i.e., weights are inverse of selection probabilities)
§Age adjusted prevalence figures using the 1980 US Census sub-populations as standards
I

7O
Comparisons of CPS II participants in the analytic cohort for self-reported ETS
analyses were conducted to contrast characteristics such as age, schooling and
'race', for individuals who filled all three spaces and those who left spaces
blank. Those who left any space blank were more likely to be older, and less
educated, and more likely to be non-whites than those who f'ti1ed the three spaces
(Table 15). However, persons who f'tlled all three fields for hours of exposure
at home, work and other places and who reportedly had zero hours of exposure
to ETS, were similar to those who left any blank space for ETS in CPS II
questionnaires. As will be discussed in Chapter 8, a possible implication of this
distribution of missing data is that perhaps blanks might not represent ETS
unexposed subjects.
Table 15. Characteristics of CPS II nonsmokers in analytic cohort
for self-reported ETS by completeness of the information provided
for ETS
Characteristic Left any ETS field Completed all ETS
blank fields Cross-product
(Column percent) (Column percent) . rati~
Age group
65 +
30-64
Schooling
<12 years
12+
'Race'
Non-whites
Whites
25.4 20.5
74.6 79.5
15.6 8.1
84.4 91.9
8.3 5.5
91.7 94.5
1.4
2.1
1.7
!
!

I
I
I
I
I
I
I
I
I
I
I
I
I
I
I
I
I
71
ii. CPS II Self-reported Exposure to ETS and Spousal Smoking
Habits
Results of the second validationlstudy that compared self-reported ETS exposure
with the smoking status of cohabitees and spouses are presented in tablel6.
Table 16.a. and 16.b show that seE-reported exposure to ETS at home by CPS
nonsmoking women and men, respectively, agreed with having at least one
current smoker among cohabi~ees: the observed agreement was 88.4% for.
women, and 94.5% of men (k=56.0%; 95% CI=55.6-56.45 for women, and
k=63.5%; 95% CI=62.7-64.3 for men). Self reported ETS (hours of exposure
at home) agreed better with the smoking status of spouses (Table 16.c. and
16.d.) than with the number of ~moking cohabitees (Table 16.a. and I6.b.); the
observed agreement was 87.8% and 95.4% for wives (Table 16.c.) and
husbands, respectively (k=62.6%; 95% CI=62.2-62.9 for nonsmoking wives,
and k=69.8%; CI=69.0-70.6, for nonsmoking husbands). We concluded that
self-reported ETS exposure in CPS II was internally consistent with the smoking
habits reported by spouses. We also concluded that self-reported ETS is closer
to spousal ETS than to smoking of cohabitees. Using current smoking status of
spouses as standard, self-reported ETS would misclassify 4.6% of the subjects,
with a specificity of 98%.
Table 16.a. Comparison of self-reported exposure to ETS at
home by CPS II nonsmoking women and the number of
........ _current smokers among cohabitees.
I
Cohabitees status
Self-reported At least one Nonsmoker and Total
ETS current smoker former smokers
.................... only,
Yes 33,951 (9.8) 17,250 (5.0) 51,201(14.8)
No 22,850 (6.6) 271,947 (78.6) 294,797 (85.2)
Total 56,801 (16.4) 289,197 (83.6) 345,998 (100.0)
kL-~6~0% (˘5% CI=55.6-56.4) ..........
I
0
0
~0
