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! I I I I I I I I I i I I I I I I I # 105 AUTHOR: WEHNER, ALFRED P., ROBERT H. BUSCH, AND RICHARD J. OLSON DATE: 1974 TITLE: EFFECT OF CHRONIC EXPOSURE TO CIGARETTE SMOKE ON TUMOR INCIDENCE IN THE SYRIAN GOLDEN HAMSTER CITATION: in EXPERIMENTAL LUNG CANCER . CARCINO_GENSIS AND BIOASSAYS, International Symposium held at Battelle Seattle Research Center, June 23-26, 1974, ED: Eberhard Karbe and James F. Park, Springer-Verlag, New York STUDY DESIGN: The results reported in this paper are part of a much larger research program. In this paper, the effect of life-span exposure to cigarette smoke on tumor incidence in the Syrian golden hamster was described. A group of 51 male Syrian golden hamsters received lifespan exposures to cigarette smoke in Hamburg II smoking machines for 10 minutes 3 times per day, 5 days per week. An additional group of 51 served as controls and received sham exposure only. At death, lungs, trachea,larynx, liver, kidneys, and tissues showing gross lesions were histopathologically examined. RNDINGSIRESULTS: The smoke-exposed hamsters had a significantly higher incidence of the following lesions than the controls= Total number of tumors Malignant tumors Epithelial lesions of the larynx = 28% vs 6% (p<0.05) = 18% vs 2% (p<O.05) = 22% vs 0% (p<O.01) The increased tumor incidence in the smoke-exposed hamsters is not necessarily a direct effect of the exposures to cigarette smoke, but might be explained by the significantly longer mean lifespan of 19.6 months of the smoke exposed group compared to 15.3 months for the controls. CONCLUSIONS/COMMENTS: The most surprising result of these experiments was the fact that the smoke-exposed animals outlived the controls by a significant margin. Factors contributing to this phenomenon might be the significantly lower mean body weight of the smoke exposed group as compared to the controls and a significantly delayed onset of amyloidosis in the smoke-exposed group.