Philip Morris
Development of Alterations in the Primary Immune Response of Mice by Exposure to Fresh Cigarette Smoke
Fields
- Author
- Holt, P.G.
- Keast, D.
- Thomas, W.R.
- Keast, D.
- Characteristic
- EXTR, EXTRA
- Master ID
- 2063594010/4240
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- Site
- R530
- Area
- CARCHMAN,RICHARD/OFFICE
- Litigation
- Iwoh/Produced
- Type
- SCRT, REPORT, SCIENTIFIC
- Named Organization
- Hamburg
- Int Arch Allergy
- Date Loaded
- 07 Jun 1999
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# 99
AUTHOR; THOMAS, W. R., P.G. HOLT, AND D. KEAST
DATE: 1974
TITLE; DEVELOPMENT OF ALTERATIONS IN THE PRIMARY IMMUNE RESPONSE OF
MICE BY EXPOSURE TO FRESH CIGARETTE SMOKE
CITATION; INT. ARCH. ALLERGY 46:481-486 (1974)
STUDY DESIGN:
Groups of five C57 Black mice were exposed to fresh cigarette smoke for 0,9,36,120,182, and
294 days. Smoking machine was the Hamburg II set to deliver a mixture of smoke/air (1:7) at a
puff volume of 35 ml. Animals were exposed daily to the mixture for 7-8 minutes. The plaque-
forming cell response present in the lung, mediastinal and cervical lymph nodes, blood and
spleen of exposed animals was measured 7 days after intratracheal inoculation with sheep
erythrocytes. This was compared to the response in age-matched controls.
RNDINGS/RESULTS:
The response in all organs showed progressive impairment over the exposure period. The
response of the lymph nodes was initially enhanced by the smoking, but after continued
exposure became severely depressed.
CONCLUSIONS/COMMENTS:
The study indicates that cigarette smoke exposure progressively impairs the primary immune
response, rather than exerting an immediate toxic effect.
