Philip Morris
Chronic Inhalation of Marijuana and Tobacco in Dogs: Pulmonary Pathology
Fields
- Author
- Boutet, M.
- Huy, N.D.
- Magnanlapointe, F.
- Roy, P.E.
- Huy, N.D.
- Characteristic
- EXTR, EXTRA
- Master ID
- 2063594010/4240
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- Site
- R530
- Area
- CARCHMAN,RICHARD/OFFICE
- Litigation
- Iwoh/Produced
- Type
- SCRT, REPORT, SCIENTIFIC
- Named Organization
- Research Communications in Chemical Path
- Date Loaded
- 07 Jun 1999
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~94
AUTHOR: ROY, P,E., F. MAGNAN-LAPOINTE, N.D. HUY, AND M. BOUTET
DATE: 1976
TITLE: CHRONIC INHALATION OF MARIJUANA AND TOBACCO IN DOGS: PULMONARY
PATHOLOGY
CITATION: RESEARCH COMMUNICATIONS IN CHEMICAL PATHOLOGY AND
PHARMACOLOGY 14(2) 305-317 (1976)
STUDY DESIGN: The pulmonary effects of chronic marijuana (M) and tobacco (T) smoke
inhalation were studied in adult female dogs. The smoke was inhaled through a tracheostomy
tube; four cigarettes containing either tobacco (3.2 g/dog) or marijuana (3.0 g/dog) were used per
day over 900 days.
RNDINGS/RESULTS:
At autopsy, the pulmonary volume and alveolar surface of the tobacco group decreased,
compared to controls and the marijuana group. The tracheostomy itself resulted in a decreased
alveolar surface and a high incidence of bronchiolitis; in the order of severity the marijuana >
tobacco > tracheostomy > control group. The incidence of squamous metaplasia also followed
this order, but the tobacco group showed more abnormalities affecting the mucosal membrane.
CONCLUSIONS:
Chronic inhalation of marijuana and tobacco produced the bronchiolitis with marcrophage
infiltration in the wall of the terminal air-passages.
