Philip Morris
Dosimetry and Cardiopulmonary Function in Rats Chronically Exposed to Cigarette Smoke.
Fields
- Author
- Carr, D.B.
- Hilton, D.I.
- Jaffe, R.A.
- Loscutoff, S.M.
- Phelps, D.W.
- Wehner, A.P.
- Hilton, D.I.
- Characteristic
- EXTR, EXTRA
- Master ID
- 2063594010/4240
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- Site
- R530
- Area
- CARCHMAN,RICHARD/OFFICE
- Litigation
- Iwoh/Produced
- Type
- SCRT, REPORT, SCIENTIFIC
- Named Organization
- Maddox
- NCI, Natl Cancer Inst
- Ornl
- Toxicology + Applied Pharmacology
- NCI, Natl Cancer Inst
- Date Loaded
- 07 Jun 1999
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~74
AUTH(~R= Loscutoff, Susan M., Richard A. Jaffe, D. lan Hilton, Daniel W. Phelps, Daniel B.
Carr, and Alfred P. Wehner
DATE: 1982
TITLE: DOSIMETRY AND CARDIOPULMONARY FUNCTION IN RATS CHRONICALLY
EXPOSED TO CIGARETTE SMOKE.
.CITATION= TOXICOLOGY AND APPLIED PHARMACOLOGY 64, 335-352 (1982)
STUD,Y DESIGN:,,Groups of 80 female F-344 rats were exposed in Maddox-ORNL smoking
machines to smoke from three types of research cigarettes provided by NCI : high tar, low
nicotine (HT-LN), low tar, high nicotine (LT-HN), and high tar, high nicotine (HT-HN). Rats were
exposed to 10 puffs of smoke (1:10 dilution), during each of eight daily exposure sessions, 7
days/week for 24 months. Additional groups were sham-exposed on same schedule, or served
as untreated "shelf" controls. Heart rate and breathing pattern (tidal volume, respiration rate, and
minute volume) were measured both during exposure and while the animals were not exposed to
smoke.
RNDINGS/RESULTS:
During exposure, smoke-exposed rats inhaled 75% less air and had 40% lower heart rates than
sham-exposed rates. Results were similar for all smoke-exposed groups, and differences
between sham- and smoke-exposed groups persisted throughout the 24-month exposure. When
not being exposed, heart rate and breathing pattern were also different between smoke and
sham-exposed groups; tidal volumes were higher and respiration and heart rates were lower in
smoke-exposed than in the sham exposed groups; tidal volumes were higher and respiration and
heart rates were lower in smoke-exposed than in sham-exposed rats. In general, these
differences between smoke and sham-exposed groups developed during the first 12 months of
exposure and diminished thereafter. Of the smoke-exposed groups, rats exposed to LT-HN
cigarettes showed the greatest changes, and the rats exposed to HT-LN cigarettes showed the
least changes, in heart rate and breathing pattems. Arterial blood pressure was consistently
higher in smoke-exposed than in sham-exposed animals following 18 and 24 months of
exposure.
This study showed that cardiopulmonary function in rats was significantly affected by chronic
cigarette smoke exposure.
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