Tobacco Smoke Inhalation Studies in Rats
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- Caton, J.
- Dalbey, W.
- Griesemer, R.
- Guerin, M.
- Kendrick, J.
- Maddox, W.
- Nettesheim, P.
- Rubin, I.
- EXTR, EXTRA
- Master ID
- 2063594012-4016 Biennial Report 960000 / 970000
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- 2063594041-4042 Passive Smoking Doesn't Cause Cancer - Official
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- 2063594050 Others' Cigs 'not Danger'
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- 2063594054-4055 Passive Smoking
- 2063594056-4059 Who Report on Passive Smoking
- 2063594060-4067 Passive Smoking
- 2063594068 Un - Passive Smoking
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- 2063594070 Second-Hand Smoke 'may Protect You'
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- 2063594077 Who Denies Quashing Passive - Smoking Study
- 2063594078 British Newspaper Says Who Withheld Smoking Study Report
- 2063594079 Un Health Agency Industry Passive Smoking Row
- 2063594080-4081 Uk: Experts Reject 'passive Smoking Safe' Claim
- 2063594082 Estudo Questiona Risco Do Fumo Passivo
- 2063594083-4084 Study Doubts of the Risk of Passive Smoking
- 2063594086 Smoking Out Bad Science
- 2063594087 Debate Gets Heated Over Interpretation of European Results
- 2063594088 Saude: Risco De Fumante Passivo E Insignificante, Diz Pesquisa.
- 2063594089-4090 Health - Second Hand Smoking Risk Is Insignificant, Say Research
- 2063594092 Rtf 03/12 0601 Interview - Gallaher Plays Down Down Passive Smoking Risk
- 2063594093 Passive Smoking Riposte to Tobacco Companies
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- 2063594098-4099 Smokescreens
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- 2063594113-4125 NCI Smoking and Health Program
- 2063594126 Carcinogenicity of Inhaled Cigarette Smoke in the Nmu - Pretreated Hamster Larynx
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- 2063594129 A Survey of Pathological Changes Associated with Long-Term High Tar Tobacco Smoke Exposure in A Murine Model
- 2063594131 the Effect of Cigarette Smoke Exposure in Europe in European Hamsters
- 2063594132 Pathological Alterations in Syrian Golden Hamsters Lungs After Passive Exposure to Cigarette Smoke
- 2063594133 Mucus Hypersecretion and Viscoelasticity Changes in Cigarette Smoking Dogs
- 2063594134 A Study of Tobacco Carcinogenesis. Xii. Epithelial Changes Induced in the Upper Respiratory Tracts of Syrian Golden Hamsters by Cigarette Smoke.
- 2063594135 Simultaneous Exposure of Chinese Hamsters to Ethanol and Cigarette Smoke, Cytogenetic Aspects
- 2063594136 Action of Intensive Cigarette Smoke Inhalations on Rat Lung. Role of Particulate and Gaseous Cofactors
- 2063594137 Differential Response of Snell's and C57 Black Mice to Chronic Inhalation of Cigarette Smoke
- 2063594138 Establishing Aerosol Exposure Concentrations for Inhalation Toxicity Studies.
- 2063594139 Dosimetry and Cardiopulmonary Function in Rats Chronically Exposed to Cigarette Smoke.
- 2063594140 the Effect of Long-Term Exposure to Cigarette Smoke on the Height and Specificity of the Secondary Immune Response to Influenza Virus in A Murine Model System.
- 2063594141 Chronic Cigarette Smoke Inhalation and Aging in Mice: 1. Morphologic and Functional Lung Abnormalities
- 2063594142 Murine Lung Response to Kaolin Conveyed by Cigarette Smoke
- 2063594143 Diesel Exhaust Is A Pulmonary Carcinogen in Rats Exposed Chronically by Inhalation
- 2063594144 Influence of Vitamin A on the Laryngeal Response of Hamsters Exposed to Cigarette Smoke
- 2063594145 Etude Des Effects De La Fumee De Cigarettes Par Inhalation Chezle Rat
- 2063594146 Effects of Chronic Daily Exposure to Tobacco Smoke on the High Leukemic Akr Strain of Mice
- 2063594147 Chronic Cigarette Sidestream Smoke Exposure Increases Rat Trachea Ornithine Decarboxylase Activity
- 2063594148 An Animal Model of Cigarette Smoking in Beagle Dogs - Correlative Evaluation of Effects on Pulmonary Function, Defense, and Morphology
- 2063594149 Experimental Respiratory Carcinogenesis in Small Laboratory Animals
- 2063594150 the Regional Deposition of Tar From Cigarette Smoke in the Rodent Respiratory Tract
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- 2063594155 Bronchial Reactivity to Inhaled Methacholine in Cigarette Smoking Baboons
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- 2063594157 Cigarette Smoking by Baboons: in Vivo Assessment of Particulate Inhalation Using Bronchoalveolar Lavage to Recover (C)Dotriacontane.
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- 2063594159 Thyroid Hormone Levels and Cigarette Smoking in Baboons
- 2063594160 Immune Responsiveness of Monkeys Exposed Chronically to Cigarette Smoke.
- 2063594161 Preliminary Studies of the Interaction Between Puo2 and Cigarette Smoke in the Mouse Lung
- 2063594162 Cellular Immunity in Mice Chronically Exposed to Fresh Cigarette
- 2063594163 Development of Alterations in the Primary Immune Response of Mice by Exposure to Fresh Cigarette Smoke
- 2063594164 the Growth of Transplanted Tumours in Mice After Chronic Inhalation of Fresh Cigarette Smoke.
- 2063594165 the Effects of Cigarette Smoke Inhalation Upon Mice During Pregnancy
- 2063594166 Chronic Inhalation of Nickel Oxide and Cigarette Smoke by Hamsters.
- 2063594167 Chronic Inhalation of Asbestos and Cigarette Smoke by Hamsters.
- 2063594168 Effect of Chronic Exposure to Cigarette Smoke on Tumor Incidence in the Syrian Golden Hamster
- 2063594169 Effects of Diethylnitrosamine and Cigarette Smoke on Hamsters
- 2063594170 Inhalation Bioassay of Cigarette Smoke in Rats
- 2063594171 Increased Life Span and Decreased Weight in Hamsters Exposed to Cigarette Smoke
- 2063594172 Relevance of Gas and Particulate Phases of Tobacco Smoke for Lung Cancer Formation: An Experimental Study in Syrian Golden Hamsters
- 2063594173 Clinical and Pathological Effects of Cigarette Smoke Exposure in Beagle Dogs
- 2063594185-4239 Cardiovascular Effects of Long-Term Cigarette Smoking and Nicotine Administration
- 2063594222-4239 Cardiovascular Effects of Long-Term Cigarette Smoking and Nicotine Administration
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! I I I I I I I I I I I I i i I I I AUTHOR: KEHDRICK, J., P IqETTESHEIM, M GUERIN, J. CATON, W. DALBEY, R. GRIESEMER, I. RUBIN AND W, MADDOX _D_..~T.~; 1976 TITL~ E; TOBACCO SMOKE INHALATION STUDIES IN RATS CITATION: TOXICOLOGY AND APPLIED PHARMACOLOGY 3_Z7, 557-569 (1976) .S_ .T U D,,Y I~ES, IGN: 3.4 month old F~male Filler-344 rats used. The intermittent MMdox/ORNL smoking machine was used for exposures.drawing a 2-see. 35 cm~ l~lff into a 3~ocm; exposure ch,'unber to produce a 10% smoke ,"cresol. Smoke remained in chamber for 28 sec. ('hamher then purged with air (4000 m Umin) for 30 sec before next puff taken. Ten rats exposed at a time. with only nostrils protruding into the chamber. Experimental cigarettes (Cmies 9 and 16) supplied by NC[. delivered 29.8 and 22.7 mg TPM and 1.75 and 1.1 mg nicotine per cisarette r~spectively. A total of 160 rate were exposed to 7-10 cigarettes/day. Ninety received lifetime exposure. 20 age-controls as ",'.'ell as 30 container controls (shams). were kept for the survival study. 70 of smoke exposed rats were sacrificed ~ter 12. 18 and 24 month of exposure for extensive biochemical, physiological, and histological evaluation. Equal numbers of controls were sacrificed at each time interval Overt signs of k'~xicity during the first exposures of the clvonic study was avoided by gradually increasing the number of ci~day ~t a weel,3y rate of I cig'day over ~t 7-10 wk period. Experimental cig,'vettes were labeled with [I~C] dotriacontane as a tr.~er for smoke-particulate deposition experiments. For tl~ del~SitK~n stud,s, rats previously adapted to tobacco smoke were expo~d first to smoke from an unlabeled cigarette and then. after a 5 rain, interval, to that from a labeled cigarette. Deposition data were expressed as amount of TPM/o~an [TPM/organ-tdpm in orgaWdpm m cigJxITPMJcig)]. F1NOINGS/RESUL TS: Both tidal volume and respiratory rate were markedly reduced during smoke exposure (25%). however respiration r~turned to nomml during the 30-sec break between puffs. For the smoke de~x~sition studies: Both hamstet.'s and rats were used. Total deposition was .38 and .34 mg of TPM in mrs and hamsters respectively, amounting to about 1.4 and 1.3% of the radioactivity offered in the smoke chamber, Of Ihe organs examined, the lung contained ,27 mg TPM while the stomach contained. 12 mg TPM. indicating movement o£ the smoke particles £rom the large airways and/or nose. Only O. 1 mg TPM was observed both the lat)'nx and head. In the lung most of the particles were localized in the dN~t inferior and left lobes. A progressive increase in total radioactivity was observed with successive exposures. Carboxyhemoglobin in these rats reached 17% atler I cigmvtte, but did not inct~ease above 30% after 5 or I0 cig. Chron.ic Ex~ure to Ci_marette Smoke Studies: The mean body weights of container controls were xveil below those of the age.controls. Restraint for 8-rain periods. 7 time per day in containet.'s used for smoke exposure apparently constitutes a major stress. The mean weights of smoke exposed t,'ats were only sliN~tly less than those of tile container controls, Survival (18 month of experiment) in the group exposed to 7 ci~day is only sliN~tly below Ihnt of the control g~oups. The moriality rate in the group exposed to t0 cig/day is consider,ably above that of the control groups (53% vs 3% container controls vs 11% age controls). Of the pathological lesions observed in the histological materials available fl'om smoke exposed rats. the mtvlt significant appear to occur in the bronchioles and alveoli. Only mild focal epithelial hyperplasias were observed in the upNr airways, BronchMitis of the terminal bronchioles and marked focal ,'-dveolitis occun'ed, each nmrked by epithelial hyperplasia and pigmented macrophages. .Q,ONCL.=US_,I,ONS: The chrorfic smoke exposure studies ate ongoing, but preliminary ~vsults indicate that the mt as a model for tob~co smoke inhalalion studies xvill offer advantages such as the l~k of chronic ~vspiratory infection and longer survival expcctan,:y. This study demonstrated that the great sertsitivity of rats to smoke toxicity could be overcome by ,~t,ndual adaptation, Smoke .induced pathological changes were observed in the tvspiratory tract only.