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Published by the International Agency for Research on Cancer, 150 cours Albert Thomas, 69372 Lyon cedex 08, France @ International Agency for Research on Cancer, 1998 Publications of the World Health Organization enjoy copyright protection in accordance with the provisions of Protocol 2 of the Universal Copyright Convention. For rights of reproduction or translation of WHO publications, in part or in toto, application should be made to the Office of Publications, World Health Organization, Geneva, Switzerland. The World Health Organization welcomes such applications. The designations employed and the presentation of the material in this publication do not imply the expression of any opinion whatsoever on the part of the Secretariat of the World Health Organization concerning the legal status of any country, territory, city, or area or of its authorities, or concerning the delimitation of its frontiers or boundaries. The mention of specific companies or of certain manufacturers' products does not imply that they are endorsed or recommended by the World Health Organization in preference to others of a similar nature that are not mentioned. Errors and omissions excepted, the names of proprietary products are distinguished by initial capital letters. The authors alone are responsible for the views expressed in this publication. Distributed on behalf of the International Agency for Research on Cancer by the Secretariat of the World Health Organization. IARC Library Cataloguing in Publication Data European multicentre case-control study of lung cancer in non-smokers : detailed results on exposure to environmental tobacco smoke ! Paolo Boffetta ... let al.] (larc technical report ; 33) 1. Lung Neoplasms 2. Neoplasms - epidemiology 3. Tobacco Smoke Pollution f. Boffetta, Paolo. II. Title Ill. Series ISBN 92 832 2405 1 (NLM Classification: W1) 100 Printed in France

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ETS exposure The questionnaire on ETS exposure was organized in five sections: (1) exposure during childhood (2) exposure from spouses and other cohabitants during adulthood (3) exposure at the workplace (4) exposure in vehicles (5) exposure in public settings. The amount of information we obtained varied between sections and was greater in sections (1), (2) and (3) than in the other ones. The questionnaire was based on a similar tool used in an international study of urinary cotinine and ETS [Riboli et af., 19901. A copy of the questionnaire is presented in section 2.2. 1.2.3 ETi S Exposure Variables The following circumstances of ETS exposure were considered separately: - childhood (parents and other adults in the house during age 0-18) - spouse - spouse and other cohabitants during adulthood (above age 18) - workplace - spouse and workplace combined - vehicles - other indoor settings In preliminary analyses, we also considered (i) ETS exposure in childhood after excluding subjects exposed during adulthood; (ii) separate analyses of ETS exposure during age 1-10 and 11-18; (iii) ETS from spouse only among subjects who were ever married; and (iv) combined ETS exposure from vehicles and other indoor settings. These analyses, however, did not add to the interpretation of the results and are not presented here. For each exposure circumstance several qualitative and quantitative exposure variables were derived from the information collected in the questionnaire. They are summarized in Table 2.1.2 and described in detail in section 2.2. 1.2.4 Statistical Analysis Odds ratios and 95 percent confidence intervals were calculated based on logistic regression models. We fitted five regression models including, in addition to the exposure variables, different potential confounders:

2.3.3 ETS from spouse .......................................................................................i27 S1 EV: Ever exposed 31TP: Exposure to different tobacco products S1 UD: Duration (years) (non overlapping) S1 DH: Duration (hours/day x years) S1 CU: Cumulative exposure (packs/day x years) S1AV: Average exposure (cigarettes/day) S1 CS: Cumulative exposure of smoking spouse (packs/day x years) SiTS: Time since last ETS exposure (years) 2.3.4 E T S from spouse and other cohabitants ...................................................181 S3EV: Ever exposed S3TP: Exposure to different tobacco products S3UD: Duration (years) (non overlapping) S3CU: Cumulative exposure (packs/day x years) S3AV: Average exposure (cigarettes/day) S3TS: Time since last ETS exposure (years) 2.3.5 ETS from workplace ..................................................................................219 WOEV: Ever exposed WOUD: Duration (years) (non overlapping) WOH: Duration (hours) (non overlapping) WOWD: Weighted duration (hours x level) WOTS: Time since last ETS exposure (years) 2.3.6 ETS from spouse and workplace .............................................................. 255 SWEV: Ever exposed SWUD: Duration (years) (non overlapping) SWDH: Duration (hours/day x years) SWTS: Time since last ETS exposure (years) 2.3.7 ETS from vehicles ..................................................................................... 283 VEEV: Ever exposed VEUD: Duration (years) (non overlapping) VEWD: Weighted duration (days x level) 2.3.8 ETS from other indoor settings ................................................................. 305 INEV: Ever exposed INUD: Duration (years) (non overlapping) INWD: Weighted duration (days x level) 2.4 Additional results ................................................................................................327 2.4.1 Test of Interaction terms 2.4.2 Comparison of conditional and unconditional logistic regression analysis 2.4.3 Test of heterogeneity of results among centres 2.4.4 Test for trend and dose response analysis, p-vaiues 2.4.5 Scatter plots: ETS during childhood ETS from spouse ETS from spouse and other cohabitants N ~ ETS from workplace ~ ~ ETS from spouse and workplace ~ ETS from vehicles ~ ~ ETS from other indoor settings ~ 0 11

1.1: introduction 1.1.1 Aims This report presents the detailed results on environmental tobacco smoke (ETS) of the analysis of the IARC European case-control study of lung cancer in non-smokers. The purpose of the presentation of the detailed results is to allow any interested person to access the many results produced that cannot be presented in scientific journals. The report is not intended to discuss in detail the interpretation of the results: this is done in a series of articles dealing with the various aspects of the results, both at the national and the international level [Boffetta et al., 1998; Nyberg et af., 1998a; Jockei et af., 1998]. 1.1.2 Scope The iARC case-control study of lung cancer in non-smokers also investigates risk factors other than ETS, namely occupational exposures, sources of indoor air pollution other than ETS, and dietary factors. This report presents only the detailed results for variables related to ETS exposure. 1.1.3 Outline The report includes a presentation of the questionnaire on ETS exposure used in the study, a description of the ETS exposure variables derived for the study, a description of the common database, and detailed tables of results. For each i= T S exposure variable, results are presented for the whole data set, for each centre and for several subgroups of cases and controls. For each set of results, we report the number of unexposed and exposed cases and controls, the odds ratios (ORs) and 95 percent confidence intervals iCis) based on various logistic regression models [Breslow and Day, E 980], the number of cases and controls with missing values and, for quantitative variables, the p-value of the test for linear trend. The tables represent a selection of the results produced during the analysis. Additional, usually computationally more complex, approaches were attempted but in most cases did not provide results different from those presented here. For example, for all quantitative variables of ETS exposure (see below), categories were re-calculated based on the centre-specific distribution rather than on the distribution of the pooled set of controls: the results of the two approaches were remarkably similar. Similarly, we treated the exposure variables continuously rather than categorically. We also performed analyses based on lagged ETS exposure and time windows: again, the results were very close to those of the corresponding uniagged and unrestricted analyses.

Exposure to_ ETS in vehicles and indoor settings (sections 2.3.7 and 2.3.8) i he results on two further sources of exposure to i= i"S, vehicles and public indoor settings, were not consistent among the centres. The range of centre-specific ORs for exposure in vehicles (based on a total of 125 exposed cases and 310 exposed controls) ranged from 0 to 2.85, with an overall estimate of 1.14 (CI 0.88-1.48). The range of estimates for ETS exposure in public indoor settings, such as restaurants (174 exposed cases and 454 exposed controls) was 0.24-2.32, with an overall estimate of 1.03 (CI 0.82-1.29). Analyses by duration of exposure did not suggest any consistent pattern for either of these two sources of ETS exposure.

Table of Contents ....................................................................................... iii List of contributors and affiliations "' Acknowiedgements .................................................................................................... ......... iii 1. Text .................................................................................................... ............................1 1.1 introciuction .................................................................................................... ........ 3 1.2 Methods .................................................................................................... ............. 4 1.3 Results .................................................................................................... ............... 8 1.4 References .................................................................................................... .......12 2. Tables .................................................................................................... ....................... e 3 2.1 Descriptive tables .................................................................................................15 2.1.1 Selected characteristics of study areas and design of study 2.1.2 ETS exposure variables 2.1.3 Missing information on potential confounders included in the regression models by centre 2.1.4 Number of cases and controls by centre 2.1.5 Distribution of subjects by centre and gender 2.1.6 Distribution of subjects by age, centre and gender 2.1.7 Mean age of subjects by centre and gender 2.1.8 Distribution of subjects by educational level, centre and gender 2.1.9 Distribution of cases by histological type, centre and gender 2.2 ETS questionnaire and description of exposure variables ................................... 27 ETS questionnaire Weights Occasional smoking ETS during childhood ETS from spouse ETS from spouse and other cohabitants ETS from workplace ETS from spouse and workplace ETS from vehicles ETS from other indoor settings 2.3 Risk estimates and descriptive statistics .............................................................. 47 2.3.1 Occasional smoking ....................................................................................49 OSTR: Ever tried to smoke OSOC: Ever smoked occasionally OSUD: Duration (years) (non overlapping) OSCU: Cumulative exposure (packs/lifetime) 2.3.2 ETS during childhood ..................................................................................73 01 EV: Ever exposed C1 EM: Ever exposed to mother C1 EF: Ever exposed to father C,1TP: Exposure to different tobacco products C1 UN: Number of smokers d1 WN: Weighted number of smokers Di US: Smoking parent years C1 WS: Weighted smoking parent years 01 UD: Duration (years) (non overlapping) C1 WD: Weighted duration (years)

1.3: Results 1.3.1 Presentation of Detailed Results The presentation of the detailed results consists mainly of tables (section 2.3) with descriptive statistics and risk estimates for the 1= s S exposure variables, organized in the following sections (the codes of each section used in naming the variables are given in parentheses): - Occasional smoking (OS) - Childhood exposure during 0-18 years of age (Cl) - Exposure from the spouse (Si) - Exposure from the spouse and other cohabitants (S3) - Exposure at the workplace (WO) - Exposure from the spouse or at the workplace (SW) - Exposure in vehicles (VE) - Exposure in other indoor settings (IN) Additional tables (section 2.4) present additional results for selected variables on heterogeneity among centres (analyses based on continuous variables) and scatter plots. g.3.2 Summary of the Main Results i he database for the analysis contained 650 cases and 1542 controls (table 2.1.4). Two of the German centres and the centres in Sweden, France and Spain contributed the largest numbers of cases. Approximately 22 percent of cases and 35 percent of controls were men. The distribution of age was very similar among cases and controls: mean age was 58 in male cases and 59 in male controls; corresponding figures for women were 62 and 62 (tables 2.1.5, 2.1.6, 2.1.7). The distribution of study subjects by education is shown in table 2.1.8, that of cases by histology in table 2.1.9. Occasional smokina (section 2.3.1) Fifteen cases and 130 controls reported that they ever tried to smoke, resulting in a significantly decreased OR (this information was missing for 170 cases and 454 controls). No overall increase in risk was present for occasional smoking of less than 400 cigarettes in total; a small excess, however, was found for squamous cell carcinoma, with the suggestion of a trend by cumulative exposure but not for duration of exposure. Childhood E i S ex osure (section 2.3.2) A total of 389 cases and 1021 controls reported exposure to ETS during childhood, and the overall OR was 0.78 (Cl 0.64-0.96). In all but three centres the OR was below 1. Subjects' fathers were more likely to be smokers than subjects' mothers were. The risk estimate was similar for exposure to ETS from the father and the mother; the estimated OR for ETS from

T ahie 2.1.3 Missing information on potential confounders included in the regression models, by center I France Germany 1 Germany 2 Germany 3 Italy I Italy 2 Italy 3 Portugal I Spain Sweden Urban residence Education Missing Note: Information on exposure to occupational carcinogens was available in all centers

List of Contributors and their Affiliations Paolo Boffetta (1), Antonio Agudo (2), Wolfgang Ahrens (3,4), Ellen Benhamou (5), Simone Benhamou (6), Sarah C. Darby (7), Gilles Ferro (1), Cristina Fortes (8), Carlos A. Gonzalez (2), Karl-Heinz Jbckei (3), Martin Krauss (1,9), Lothar Kreienbrock (9), Michaela Kreuzer (9), Anabela Mendes (10), Franco Merletti (11), Fredrik Nyberg (12), Goran Pershagen (12), Hermann Pohlabeln (4), Elio Riboli (1), Giovanni Schmid (13), Lorenzo Simonato (14), Jean Tredaniel (15), Elise Whitley (7), Heinz-Erich Wichmann (9), Carlos Winck (16), Paoia Zambon (13), Rodolfo Saracci (1, 17) 1. International Agency for Research on Cancer, Lyon, France 2. Institute for Epidemiological and Clinical Research, Matarb, Spain 3. Institute for Medical Informatics, Biometry and Epidemiology, Essen, Germany 4. Bremen Institute for Prevention Research, Bremen, Germany 5. Institute Gustave Roussy, Paris, France 6. National Institute of Health and Medical Research, Paris, France 7. Imperial Cancer Research Fund, Oxford, United Kingdom 8. Epidemiology Unit Latium Region, Rome, Italy 9. GSF Institute for Epidemiology, Munich, Germany 10. Regional Health Administration, Lisbon, Portugal 11. Unit of Cancer Epidemiology, University of Turin, Turin, Italy 12. Karolinska Institute, Stockholm, Sweden 13. Forianini Hospital, Rome, Italy 14. Venetian Cancer Registry, Padua, Italy 15. St Louis Hospital, Paris, France 16. Hospital Viana do Castelo, Viana do Castelo, Portugal 17. National Research Council, Pisa, Italy Acknowledgements The study was partially supported by the following grants: IARC: European Commission DG-XII (Contract No. EV5V-CT94-0555) for the coordination France: Association pour Ia Recherche sur ie Cancer; European Commission (90CVV01018); Caisse Nationale d'Assurance Maladie des Travailleurs Sociaux Germany 1: Federal Ministry for Education, Science, Research and Technology (grant No. 01 HK 546); Federal Ministry of Work and Social Affairs (grant No. IIIb 7-2.'/13) Germany 2: Federal Office of Radiation Protection, Salzgitter (grant No. St Sch 1066, 4047, 4074/1) Germany 3: Federal ®ffice of Radiation Protection, Salzgitter (grant No. St Sch 4006, 4112) Italy 1: MURST; Italian Association for Cancer Research (AIRC); Regione Piemonte- Ricerca Finalizzata Italy 2: National Research Council (contract No. 91.00327.CT04); Italian Association for Cancer Research (AIRC) Portugal 1: Junta Nacional de investigagao Cientifica e Tecnologica (JNICT, contract No. PMCT/C/SAU/815.90) Portugal 2: Comissao de Fomento de investigaqao em Cuidados de Saude 111

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1.4: References Becher H, Zatonski W, Jockef KH. Passive smoking in Germany and Poland: comparison of exposure levels, sources of exposure, validity, and perception. Epidemiology 1992;3:509- 514. Boffetta P, Agudo A, Ahrens W, Benhamou E, Benhamou S, Darby SC, Ferro G, Fortes C, Gonzalez CA, Jockel KH, Krauss M, Kreienbrock L, Kreuzer M, Mendes A, Merietti F, Nyberg F, Pershagen G, Pohlabeln H, Riboli E, Schmid G, Simonato L, `l°redaniel J, Whitley E, Wichmann HE, Winck C, Zambon P, Saracci R. Multicenter case-control study of exposure to environmental tobacco smoke and lung cancer in Europe. J Natl Cancer Inst 1998;90 (in press). Bresiow NE, Day NE. Statistical Methods in Cancer Research, Vol. I, The Analysis of Case- Control Studies (IARC Scientific Publications No. 32). Lyon: International Agency for Research on Cancer, 1980. Jockei KH, Pohlabeln H, Ahrens W, Krauss M. Environmental tobacco smoke in Germany. Epidemiology (in press). Nyberg F, Agrenius V, Svartengren K, Svensson C, Pershagen G. Environmental tobacco smoke and lung cancer in nonsmokers - does time since exposure play a role? Epidemiology 1998a;9:301-308. Nyberg F, Agudo A, Boffetta P, Fortes C, Conzalez CA, Pershagen GA. European validation study of smoking status and environmental tobacco smoke exposure in nonsmoking lung cancer cases and controls. Cancer Causes Control 1998b;9:173-182. Riboli E, Preston-Martin S, Saracci R, Haley NJ, Trichopoulos D, Becher H, Burch JD, Fontham ETH, Gao YT, Jindal SK, Koo LC, Le Marchand L, Segnan N, Shimizu H, Stanta G, Wu-Williams AH, Zatonski W. Exposure of nonsmoking women to environmental tobacco smoke: a 10-country collaborative study. Cancer Causes Control 1998; 1:243-252.

INTERNATIONAL AGENC r FOR RESEARCH ON CANCER WORLD HEALTH ORGANfZATION European W-fuiticentre Case-Coritrol Study of Lung Cancer in Non-smokers Detailed Results on Exposure to Environmental Tobacco Smoke Paoio Boffetta, Antonio Agudo, Wolfgang Ahrens, Ellen Benhamou, Simone Benhamou, Sarah C. Darby, Gilles Ferro, Cristina Fortes, Carlos A. Gonzalez, Karl-Heinz Jockei, Martin Krauss, Lothar Kreienbrock, Fviichaela Kreuzer, Anabela Mendes, ~=ranco Merletti, Fredrik Nyberg, Goran Pershagen, Hermann Pohlabein, Elio Riboli, Giovanni Schmid, Lorenzo Simonato, Jean Tredaniei, Elise Whitley, Heinz-Erich Wichmann, Carlos Winck, Paola Zambon, Rodolfo Saracci IARC Technical Report No. 33 Lyon, 1998

1.2: Methods 1.2.1 Study Setting The study was conducted in twelve centres from seven European countries: three each from Germany and Italy, two from Portugal, and one each from Sweden, the United Kingdom, France and Spain. Details of the study design varied among centres; Table 2.1.1 presents selected features of the design. The period of enrolment of cases and controls lasted from 11988 to 1994. The most important difference in the study design among centres was the selection of controls: clinic-based in the centres from France, Portugal, Spain and in one Italian centre; both clinic- and community-based in the centre from the United Kingdom; and community-based in the other centres, The diagnoses of clinic-based controls varied among centres: patients with smoking-related diseases were excluded from the control series in all centres. i here were minor differences among centres regarding age restriction and diagnostic criteria for case eligibility. In some centres there was no age restriction, while in others subjects aged 76 or older were excluded. This combined analysis is therefore restricted to cases and controls up to age 75. Apart from a section on ETS (see below), the common questionnaire included sections on demographic variables, residential history including history of cooking and heating habits, and exposure to known and suspected occupational lung carcinogens. In addition, the centres from Germany, Sweden, Spain, the United Kingdom and France and one Italian centre collected information on dietary habits, from which indicators of intake of vegetables were derived based on country-specific tables of food composition. 1.2.2 The ETS Questionnaire Occasional smoking I he questionnaire included a section aimed at identifying regular smokers, defined as smokers of at least 400 cigarettes or the equivalent amount of cigars or tobacco for pipe. This amount corresponds to about one cigarette per day during one year. Smokers were to be excluded from the study and the questionnaire on ETS exposure was intended to be administered to never smokers. However, the identification of very weak smokers was problematic: therefore, the questionnaire on ETS exposure was introduced by a detailed questionnaire on occasional smoking, aiming to identify low level or discontinuous smoking habits.

(I) age (5 categories), sex, centre and sex-centre interaction terms; (ii) as (i), plus proportion of residence in urban setting during the last 35 years (3 categories); (iii) as (ii), plus education level (3 categories); (iv) as (i), plus duration of exposure to occupational lung carcinogens (4 categories); (v) as (i), plus frequency of consumption of vegetables (2 categories). Educational level was categorized in 3 levels, based on country specific cutpoints aimed to identify low (usually equivalent to primary school), intermediate (equivalent to iunior high school or secondary school) and high educational level (Table 2.1.8). Exposure to occupational carcinogens was categorized in 4 levels (unexposed, 1 st-75th percentile, ?5th-90th percentile and >90th percentile). Consumption of vegetables was categorized based on the median of the consumption of controls. Information on some of the confounders was not collected in selected centres. These cases and controls were excluded from the corresponding analyses (Table 2.1.3). All analyses were repeated after restriction to centres with information on education and residential history and those with information on vegetable consumption. The interaction terms between sex and centre were retained in all regression models since in preliminary analyses their inclusion improved significantly the fit of the models (Table 2.4.1). Their inclusion however affected the results of the ETS exposure indicators only to a minor extent. For selected exposure variables we compared the risk estimates derived from conditional and unconditional logistic regression for the four centres with individually matched data (France, Portugal 1, Spain and United Kingdom) (Table 2.4.2). The unconditional regression model was adjusted for sex, age and centre, as well as for the interaction term sex*centre as in model (i) above. In order to evaluate the differences between the centre-specific results a test for heterogeneity was calculated. This was done by comparing the deviances of regression models excluding and including the interaction terms between the exposure variables and the centre (Table 2.4.3). The difference in the deviances of these two models follows aX2 distribution with degrees of freedom equal to the number of interaction terms. A test for linear trend was calculated by including a trend variable in the logistic model and by testing the significance of the corresponding regression parameter. This was done using a categorical variable with values taken at the median of each exposure category of the variable (Table 2.4.4). We also produced scatter plots of the centre-specific results for selected variables by plotting the ORs against the inverse of their variance (section 2.4.5).

wo ETS from WORKPLACE WOEV Everexposed WOUD Duration (years) n _ jAage, non overlapping WOH Duration (hours) n _~(Aage x 52 x(hours / day) x (days / week)), non overlapping ~ WOWD Weighted duration (hours x level) » _~(Aage x 52 x TrVT3 x(hours / day) x(days / week)) , WOTS Time since last ETS exposure (years) ionnaire and descriotion of exoosure variables

Questionnaire on occasionai smoking and environmental tobacco smoke k'E TS) Tobacco smoking e Did you ever smoke for longer than one year? Yes..1; No..2 I or more cigarettes/day or half a pack of cigarettes/week or 2 or more packs/month or 4 or more cigarillos/week or 3 or more cigars/week or 3 or more pipes/week if YES to at least one of the questions, go to "Active smoking" section if NO, continue with the next question • Did you ever try to smoke? Yes..".; No ..2 1--i • Have you ever smoked cigarettes, cigar or pipe, even very few occasionally during a social occasion andlor at a particular period of your life? Yes ..1,; No ..2- 17 If yes, from what age did you smoke occasionally? What did you smoke? Cigarettes Filter ....................... I Non filter ................. 2 Cigar ........................ 3 Pipe .......................... 4 Cigarette & pipe ....... 5 ~ ~ i-j U • Did you inhale tobacco smoke? 1:1 Not at all, only in the mouth ....... I A little, just in the throat 2 ............. ~ Deeply into the lung ................... 3 If during this period you smoked mainly the same brand, indicate the brand (otherwise skip) How many? Frequency Per day ......... I Per week ...... 2 Per month ..... 3 Per year........ 4 Per lifetime ... 5 D o` ETS auestionnaire and description of exposure variables

For most quantitative variables, the categorization was done based on the distribution of controls, with cut-points chosen at the 75th and the 90th percentile. Such variables therefore have four categories(unexposed, ist-75th percentile, 76th-90th percentile and >90th percentile); their names start with the letter C. For selected quantitative variables an additional approach was chosen, after combining the unexposed and the lowest exposed groups: the names of these variables begin with the letter D (Table 2.1.2). The choice of the cut-point at the 75th percentile was based on a European study indicating that misclassification of ETS exposure is higher below the 75th percentile of the distribution [Becher et al., 1992]. In general, subjects with missing information on some items of the questionnaire, resulting in a missing exposure variable, were excluded from the analysis for that variable. However, if information for less than 25 percent of the duration of ETS exposure from cohabitants or at the workplace was missing, the average value of the rest of the period of exposure was assigned to the missing period. 1.2.5 Analysis of Subgroups of Cases and Controls Analyses were performed for all centres and for each centre separately. In addition, analyses were conducted on men and women and on centres with popufation-based controls (the three German centres, Italy 1, Italy 2, Sweden and United Kingdom) and centres with clinic- based controls (Itafy 3, France, Spain and the two centres from Portugal). An additional analysis excluded occasional smokers (164 cases and 438 controls who smoked between 1 and 400 cigarettes during their life). We conducted analyses stratified on age (<55, 55-64, and 65-75) and on type of residence (>75 percent of life in urban areas and >75 percent in non-urban areas). Finally, we restricted the analysis to histologically confirmed cases (627/650) and we classified them as squamous cell carcinoma (109 cases), small cell carcinoma (70 cases), adenocarcinoma (333 cases), and other and unknown histologies (115 cases) (Table 2.1.9). In the analysis by histological type, each group of cases was compared with the whole series of controls. 't .2.6 Validation Study We carried out a validation study by interviewing relatives of cases and controls on the non- smoking status of the study subjects. in one of the centres, spouses have also been interviewed regarding their own smoking habits, to validate the report of exposure to ETS ~ from the spouse given by the study subjects. The results of the validation study have been ~ reported separately [Nyberg et ai., 1998b] and are not discussed in detail here. ~ ~ ~ ~ ~ ~

C1 ETS during CHILDHOOD Childhood 0-18 years C'i EV C1 EM C1 EF CITP C'I UN Everexposed Ever exposed to mother Ever exposed to father Exposure to different tobacco products Number of smokers rt _ ~TTSE I C1WN Weighted number of smokers n WTSPE ~ E C1 US Smoking parent years n = 7 (AagexWTSE) I C1 WS Weighted smoking parent years ~ m ~ (dage x WTSPE ) *711 C1 UD Duration (years) n 7:age, non overlapping C1 WD Weighted duration (years) n = 7 (dagexWT,20 I €T_S auestionnair_e_andslescdaYioo_of-exaosure-variahias

IIEIGHTS Tobacco product (WT1) Cigarette =1 Cigarette, filter =1 Cigarette, non filter =1 Cigar =3 Pipe =3 Cigarette & pipe =1 Cigarette & cigar =1 Cigar & pipe Cigarette & cigar & pipe Cigarillo _2 Cigarette & cigarillo Pipe & cigarillo _4 Cigar & cigarillo =3 Pipe & cigar & cigarillo =4 Cigarette & cigar & cigarillo =1 Cigarette & pipe & cigarillo Cigarette & cigar & pipe & cigarillo =1 Cigarettes consumption frequency (WT2) Every day = 1 5-6 days/week = 0.75 2-4 days/week = 0.5 Rarely = 0.1 Level of smokyness (WT3) Very smoky ~ I Fairly smoky = 0.5 A little smoky = 0.2 Consumption frequency (WT4) Per day = 365 Per week = 52 Per month = 12 Per year = 1 -~ ~ S k i l t WTSE mo er equ va en s ( ) ~ Each single relative 1 w ~ (Father, mother other) ~ , ~ Smoking parent equivalents (WTSPE) Mother = 1 Father = 0.75 Other relatives = 0.25 -=-'r-C n..ne~tinn..ni.n nn.i_d.-.-...:..Fl.... ..F ..v ........... ..n....l.l'...__

VE ETS from VEHICLES VEEV Ever exposed VEUD Duration (years) .11 = 7.:5age, non overlapping VEWD Weighted duration (days x levei) ®age x 365 x WT3 x hour~s / day ') ,~ 4 ` FTS questionnaire and description of exposure variables

SW SWEV ETS from SPOUSE and WORKPLACE Everexposed SWUD Duration (years) n = ' ::uzge, non overlapping SWDH Weighted duration (hours/day x years) = ~i ~agexWT2x (Sxhour.~WD)+(2xhours'WE)1 ~ SWTS WD=Weekday WE=Weekend a , ,. - Time since last ETS exposure (years) ETS auestionnaire_andd-escrin tw-of-ex2osu_re uaria6lPc

2,3,1 Occasionai smokim~ Risk estimates a Risk estimates - Occasional smoking

IN ETS from OTHER INDOOR SE177 INGS INEV Everexposed INUD Duration (years) n -Aage, non overlapping INWD Weighted d uration (days x level) Aagex365xWT3xhoursfdayI ; ~4 ~ E2,Q.allacfinnnaira anri rioccdntienn nf._exn~surP variahfps

the father was 0.76 (Cl, 0.61-0.94), while that for ETS from the mother was 0.92 (0.57-1.49). There was no trend in risk according to number of smokers in the household and a decreasing trend according to cumulative exposure expressed either as smoker-years or weighted smoker-years. The risk of lung cancer from exposure to ETS during childhood was similar in men and women. No pattern emerged according to age at diagnosis or histological type of lung cancer. Results similar to those derived for any exposure in childhood, although more unstable because of small numbers in the various categories, were obtained after excluding subjects who reported exposure to ETS during adulthood. When exposure to ETS in childhood was subdivided into two periods, from age 0 to 10 and from age 11 to 18, to take into account the different status of the growth of the lung, the results for either period were similar to those for the entire childhood. Exposure to ETS from the spouse (sections 2.3.3 and 2.3.4) Exposure to spousal smoke was reported by 344 cases and 700 controls, yielding an OR of 1.16 (Cl 0.93-1.44). The twelve centres in the study showed some heterogeneity in the risk estimate for this variable, with an OR higher than 1.5 in four centres and an OR lower than 0.7 in one centre. The tests of heterogeneity performed on centre-specific results, however, did not suggest significant differences: the addition of the interaction terms between spousal exposure and centre did not improve significantly the model (difference in deviance 11.28, 11 degrees of freedom, p=0.42). There was some indication of an increasing risk of lung cancer with increasing cumulative exposure to ETS from the spouse, while no clear trend emerged for average exposure or for years of exposure. When duration of exposure was expressed as the product of hours per day and years of exposure, a positive dose-response was shown. The analysis on type of tobacco product smoked by the spouse was hampered by the small number of cases (N=12) and controls (N=27) who reported exposure to smoke from cigar and pipe only. The OR in this group was OR 0.84 (Cl 0.41-1.73), while the ORs for exposure to E i S from cigarettes were similar to those for E i S from any type of tobacco product. The other potential risk factors of lung cancer, educational level, residence in urban areas, occupational exposure to carcinogens and intake of vegetables exerted only a minor confounding effect on the association between exposure to spousal smoke and lung cancer. When study subjects were stratified by gender, the OR for exposure to spousal smoke was 1.47 (CI 0.81-2.66, based on 23 exposed cases and 68 exposed controls) among men, compared to 1.11 (CI 0.88-1.39) among women. The small number of exposed men hampered more detailed quantitative analyses. When we stratified the data by age at interview, no increase in risk was present among subjects age less than 55 (OR 0.99, Cl 0.64-1.552).

Questionnaire on occasionai smoking and environmental tobacco smoke (E'1'S) ETS from other cohabitants Smokers who lived with you in the same house or visited your house regularly, other than your spouse. Use more than one line for subjects who smoked more than one tobacco product in the same period. Did heishe smoke in your presence? What did he/ she smoke? I-Every day ...............1 Period Almost every day....2 Ci g a rette s...........1 (5-6 da_ysiweek) 3 s/week 2 2 4 d i How many cigarettes (cigars, pipes) did he/she smoke in your presence on average? For how many hours/day were you exposed to tobacco smoke from him/ her on average? ........ - ay gars ................. From To C age age Pipe .................... 3 Rarely .....................4 (years) (years) Cigarette & pipe.. 4 Never ......................5 Holidays Weekdays Weekends Weekdays Holidays Weekends ®D FIC ~CC ®~ ~ ® 00 07 ED 00 0 ~ EID ®© 1:1 L-J ®~ ~® ~~ ®i ®EI ®71 L ' J ® ME ®E D0 ED 710 ID® El D® E:11-1 00 D0 00 ~~ ~~ ~~ 100 (iG 0 El DC ED ED DD ETS nrrPStionnaira anci riPCnrfotion oi_exn4SUr_e-marialoles

~'able 2. 1.4 Number of cases and controls by center Subjects ~ Excluded (1) Excluded (2) i Excluded (3) Subjects in the database fn the analysis i Cases Controls ~ Cases Controls 3 I Cases Controls Cases Controls I Cases ~ Controls ~ 11 France 99 1 198 13 29 ( 9 I 18 ) 77 i51 ~ Germany 1 88 j 273 9 32 ~ ~ 3 ~ 12 I 76 229 Germany 2 148 170 6 7 I i ~ 142 ~ 163 Germany 3 32 ~ 52 1 . ; . ~ .~ 31 ° 52 Italy 1 451 243 E 5 22 ~ E 40 221 ~ E Italy 2 ~ 21 ~ _ 185 ~ 2 11 . 1 19 173 Italy 3 18 56 ~ 21 2 4 16 50 Portugal 1 541 47 I , 1€ 2 € 4 I 6 491 39 Portugal 2 38 59 1 2~ 1~ 3 4 ~ 33 53 Spain 881 . 1991 3 3 . i 14 37 71 159 Sweden 97 E 1731 7! 15 I 20 I I 46 70 112 ~ United Kingdom 271 1451 1 ~ 5 26 140 Total 755~ 18001. 491 1301 1 55 128~ 650 1542 Exclusions (1) Occasional smokers of more than 400 cigarette-equivalents/lifetime (2) Subjects with unknown age (3) Subjects older than 75

0S OCCASIONAL SMOKING OSTR 0S0C OSUD Ever tried to smoke Ever smoked occasionally Duration (years) n = ~ :~age, non overlapping OSCU Cumulative exposure (packs/lifetime) = i 7 (AaggexWTlxWT4x.No.smoked)l /20 7 (IT'T1 x 1Yo.smoked ) 1l 20, when W'14=1,ifetime " , 1 f ETS questionnaire and description of exposure variables

The association between lung cancer exposure to ETS from the spouse was stronger for squamous cell and small cell carcinoma than for adenocarcinoma. For squamous cell carcinoma, a dose response relation, although weak, was present with duration of exposure and cumulative exposure to spouse smoke. The other histological types, and in particular adenocarcinoma, did not show such a pattern. The small number of cases of small cell carcinoma limited the precision of the risk estimates for this histological type. T he questionnaire comprised questions on smoking habits of cohabitants other than the spouse during the adult life of the study subjects. A total of 44 (6.8 percent) cases and 123 (8.0 percent) controls who were not exposed to spousal smoke reported this source of exposure to ETS. The risks from exposure to ETS from any cohabitant were somehow lower than those of exposure to spousal smoke only (OR of ever exposed 1.10, Cl 0.89-1.37; ORs of cumulative exposure 0.96, 1.02 and 1.37 for 0.1-13.0, 13.1-25.0 and 25.1+ pack-years). Workplace exposure to ETS (section 2.3.5) A total of 374 cases and 855 controls reported exposure to ETS at the workplace, yielding an OR of 1.17 (Cl 0.94-1.45). The estimates in eight centres were above 1, although some heterogeneity was present among the centres (inclusion of the interaction terms: p-value 0.23). Exposure at the workplace resulted in a similar risk estimate in men (OR 1.13, Cl 0.68- 1.86, based on 105 exposed cases and 379 exposed controls) and in women (OR 1.19, Cl 0.94-1.51); a similar pattern was found for duration of exposure to workplace ETS. No pattern was found according to age at interview. The effect of exposure to ETS at the workplace and of its duration was stronger for squamous cell carcinomas than for other histological types. The potential confounders - educational level, residence in urban areas, occupational carcinogens and intake of vegetables, retinoids and carotenoids - had no appreciable effect on the ORs of workplace ETS exposure. Combined s o~usaf and workplace ETS exposure (section 2.3.6) Exposure to either of the two major sources of ETS, the spouse and the workplace, was associated with an OR of 1.14 (Cl 0.88-1.47); the heterogeneity among centres was smaller than exposure to ETS from the spouse and the workplace taken separately. A weak increase in lung cancer risk was present for increasing duration of exposure. The trend was stronger when duration was expressed as the product of hours/day and years of exposure (OR in the highest category 1.46, Cl 0.96-2.22). ETS exposure from the two sources that had stopped since 15 years or more was not associated with an increased risk of lung cancer. The effect of exposure to either source was similar in men (OR 1.13) and in women (OR 1.15), and was higher among subjects aged 65 or more than among younger subjects. Duration of exposure to ETS from either sources exerted a stronger carcinogenic effect on squamous cell and small cell carcinomas than on other histological types. A lower risk among subjects whose ETS exposure ceased 15 or more years before was found for all histological types.

Questionnaire on occasional smoking and environmental tobacco smoke (ETS) ETS during childhood and until subject left parents' home • Going back to your childhood, I would like to know if you ever lived with any person who used to smoke in your presence. First of all, I would like to know whether your father or your mother used to smoke when you were a child. if the subject is aware that one or both parents smoked since his/her birth, starting age=0. What did he/she smoke? Did heishe smoke in your presence? €,igarettes ............... I Cigars ..................... 2 Pipe ........................ 3 Cigarette & pipe ..... 4 Don't remember ..... 8 Relationship Non-smoker............ 9 Father J Mother E:11 E17 70 1171 • Now I would like to know about any other person who lived in your home or with whom you lived for longer than six months or who was a very regular visitor to your home, who used to smoke in your presence (brother, sister, other relatives, friends, visitors, etc...). .................... .................... .................... 77 F7F7, F77 17 F7 aF-I 771 • I would like you to try to remember how long you used to spend in a smoky room (outside the home, including school but excluding the workplace and vehicles). Would you say that the room was usually: How many hours From To in a room with age age tobacco smoke? 10C ~® ~11 E 117- 0® . :11117 Y ............. ~ Fvery da ~ Almost every day. .2 (5-6 days/week) 2-4 daysiweek...... 3 i2arefy ...................4 From i o Never ....................5 age age Very smoky ............................................. I Frequency (you could see clouds of smoke in the air) Fairly smoky ........................................... 2 Per day..........1 (you could see diffuse smoke in the air) Per week .......2 A little smoky .......................................... 3 Per month......3 (you could only smell the smoke) r-; ~ ~ •At what age did you leave your parents' home? (still leaving there =99) E17 intinn of Pxnnaure variables

2063593265 6 m I= W % IDEIIIWWI0II ;p

Table 2.1.7 Mean age of subjects by center and gender Men Women Both genders ~ Cases Controls I Cases Controls i Cases ~ Controls N 14 ( 23 63 128 77 151 France ~ Mean 51.7 ~ 55.0 59.2 59.6 57.9 58.9 ~~ Stddev 16.2 16.2 10.6 ~ 9.7 12.0 11.0 f N 18 129 58 100 1 76 ~ 229 ~ Germany I j Mean 54.6 58.4 65.1 I 62.7 62.6 i 60.3 i I; Stddev 11.2 . 9.3 ~ 8.3 8.8 ~ 10.0 ~ 9.3 ~ N 29 ~ 65 113 ~ 98 142 163 Germany 2 ! Mean 56.2 ~ 57.1 61.0 61.3 60.0 59.6 ~ Stddev 9.4 8.2 8.5 8.4 8.9 8.6 N 10 14 21 38 31 52 Germany 3 ~ Mean 57.8 ~ 59.6 63.0 62.9 61.3 f 62.0 ~ --S tddev 7.1 i 10.1 7.0 8.0 I 7.9 I 8.6 ~ I N 8 103 ~ 32 118 40 221 Italy I Mean 60.8 l 61.1 61.1 62.0 61.1 61.6 Stddev 8.9 I 9.4 ~ 7.7 9.6 7.8 9.5 ~ N 3 ~ 97 16 76 19 173 Italy 2 f Mean 61.3 60.8 ( 62.0 62.1 61.9 61.4 ' ~ Stddev 16.3 8.3 I 6.5 i 8.4 8.0 8.3 N 1 12 I 15 38 16 50 j Italy 3 1 Mean 39.0 f 53.2 I 65.7 i 61.0 ~ 64.1 59.1 j Stddev . i 12,0 ~ 6.6 ~ 11.1 ~ 9.3 11.7 N 16 8 ~ 33 31 49 39 Portugal 1 Mean 59.3 I 52.5 ~ 57.1 i 57.0 57.8 56.1 ~ Stddev 10.5 ' 6.6 ~ 9.1 ~ ~ 10.1 9.5 9.6 N 10 17 23 36 33 53 Portugal 2 ~ Mean , 57.5 ` 51.4 60.3 59.8 59.5 57.1 ! Stddev 8.1 I 9.0 11.7 10.4 10.7 10.6 N 6~ 13 65 i 146 71 159 Spain I Mean 63.2 ~ 62.8 61.9 , 61.6 I. 62.0 61.7 ' . _. _. Stddev F- .._.. ._ _ 12.8 ~ . 8.8 10.7 I. . 9.9 10.8 9.8 N 23 36I 47I 76 70 112 Sweden ~ Mean 62.6 ~ 60.6 ( 62.0 II 59.7 I 62.2 60.0 : Stddev 9.9 11.6 1 10.8 I 11.0 10.4 11.2 E N 3 1 14 23 126 26 140 United Kingdom ~ Mean 57.7 I 64.7 ~ 65.3 65.3 64.5 65.2 ~ Stddev 18.1 ~ 11.3 5.4 5.9 7.7 6.5 ~ N 141 531 509. 1011 650 1542 Total Mean 57.7 59.1 i. 61.6 61.6 60.8 60.8 F Stddev 11.1 I 9.9 9.4 ~ 9.3 9.9 9.6

Table 2.1. 1 Selected characteristics of study areas and design of study Sources of cases ~ Specific Sources of I Diseases of Response ( Study ~ inclusion criteria ~ controls, matching hospital controls i rate ~ ~ period . j variables i. ~ fca/co) I ~ rance Patients from 12 _ ~ Patients from hospitals I. Diseases not related to A ~ 1989-1993 hospitals (9 in Paris) ~ of cases ~ tobacco smoking G 1 Residents in Bremen and F tr lit kf t Birth ,1913, P l ti i t NA { 69/68 1988 1993 1 ermany me opo an ran ur iGerman nationality ~ opu on reg a s ers + ; - areas i I Residents in parts of ~ Residence in Population registers Germany 2 Northrhine-Westfalia, Germany > 25 years and random digit NA 79/38 1990-1993 Eifel and Saarland dialing Germany 3 Residents in Thuringia Residence in Population registers i NA 73/45 1990-1993 and Saxony Germany > 25 years Italy 1 Residents in Turin ; : Population registers I I NA 77/83 1991-1992 € Italy 2 Residents in 5 areas of ~- ~ Population registers f NA 72174 1990-1994 Veneto region ~ i i taly 3 Patients from one Age > 34, residence Patients from hospitals I Orthopedic, minor j I I 74/63 993-1994 hospital in Rome l in Rome region i of cases l endoc ine d seases ~ ~ i P fr it l ti t 3 h I Port ~ Patients from hos itals I Disea es not elated to I Portugal 1 a en om osp a s s uguese p s r { 55/47 1989 1992 In Lisbon i i nationali ty of cases tobacco smoking I Portugal 2 Patients from one i hospital in Vila Nova de i- Visitors in hospitats of I NA l 77/96 f 1989-1994 i Gala cases , Residents in Barcelona I Patients from hospitals f Diseases not related to Spain metropolitan area i i i i of cases tobacco smoking ~ 91/97 1988 1992 Sweden Residents in Stockholm IAge > 30 Population registers I NA ~ 86/83 ; 1989-1994 county i United Kingdom Residents in Devon and jResidence in study l l Population registers and patients from IDiseases not related to 79/93 (C ); 1988-1993 area > 20 years Comwall hospitals of cases tobacco smoking 74 (P) ~ NA Not avallable C Clinic bases P Population bases controls ENT Ear, nose and throat CYN

S3 E T Sfrom SPOUSE and OTHER COHABITANTS S3EV S3TP S3UD Ever exposed Exposure to different tobacco products Duration (years) „ _ 7 Aage , non overlapping ~ S3CU Cumulative exposure (packsfday x years) `AtigexW7lxTT'T2x (5xamouniO+(2 xamounfW ~ /20 ~ 7 S3AV S3TS Average exposure (cigaretteslday) = 20 x (C'umulative exposure/Duration ) Time since last ETS exposure (years) WD=Weekday WE=Wekend ETS auestionnaire a~d_i~escli4t on of exoosure_v__ariables

Table 2.1.2 Es S exposure variables 1 Variable Childhood Spouse Spouse Workpiace i Spouse Vehicles ~ Other ~ (C1) (Si) and other ~ (1NO) j and (VE) 1 indoors ~ cohabitants ~ I workplace (IN) ~ (S3) ~ (SW) Everexposed E_C1EV E S1EV ~ E_S3EV ! E_WOEV 1 I ESWEV f E VEfEV 1 I ~ E INEV Ever exposed - mother E_C1 EM Ever exposed -father F E_C1EF ' Exposure to different E C1TP ~ E S1TP i E S3TP E i 1 i tobacco products 1 ~ Number of smokers C_ C1 UN f Weigthed number of ~ ; ! ~ 1 WN C smokers ~ ~ j Smoking parent years ® C~ C1US' F~ ~ I , Welgthed smoking parent C C1WS' ~ years -- i : j N Duration (years) C~C1UD ! C_S1UD' ~ C~S3UD' ~ C_'1VOUD' CsSWUD' f 1 CiVEUD' C_lNUD' Weigthed duration (years) j WD- C._.C1 ~ CQWOWD' ' ~ C~~~~EWD' C_INWD~ ' I Duration (Hours/day x ~ i S1DH' ~ C ~ C SWDH' years) 11 I ~_ ! _ Duration (Hours) ~ ! C WOH* i I Cumulative exposure ( C S1CU, ; C S3CU' I (packs/day x years) I f 1 ' ~ Average (cigarettes/day) ~ C S1AV* € C~S3AV ! I Cumulative exposure of ~ smoking spouse (packs/day x years) C_S1CS' ~ e -0 Time since last exposure i S1TS { C C S3TS C WOTS C SWTS ~ol ~~ (years) . i i (') Also D- variables with reference category including non-exposed and exposed up to 75'" percentile

S1 ETS from SPOUSE SIEV SITP S1 UD Ever exposed Exposure to different tobacco products Duration (years) n rige, non overlapping _ ' j A S1 DH Weighted duration (hours/day x years) = _(&zgexYYT2x (5xhours`WD)+(2xhour9'Tm) E , '' l S1 CU Cumulative exposure (packsfday x years) vagexw71xWTlx(SxamountWDj+(2xamountWEj )/20 7 S'1 AV Average exposure (,cigarettesiday) = 20 x (Gumul'ative exposure/Duration) S1 CS Cumutative exposure of smoking spouse (packsiday x years) ,= n r = f~(Aage x WT l x amount / day ) +/ 20 rz SITS Time since last ETS exposure (years) WD=Weekday WE=Weekend

Questionnaire on occasional smoking and environmentai tobacco smoke (ETS) ETS indoors In places other than the home, work premises or vehicles e.g. restaurants, bars, pubs, cinemas, theatres, friends' homes, etc. e E would like to know if you have ever spent regularly (at least once a week) some time in a smoky place (or where you could at least smell tobacco smoke) indoors other than at home or at work. Yes ..1; No..2 [] If NO, go to next page. Specify where exposure took place Would you say that the place was Period usuali_v: How many hours per From To week were you Very smoky ......... 1 age age exposed to tobacco Fairly smoky ........2 (years) (years) smoke in this place? A iittle smoky .......3 .................... 17Ca El ................... 110 0~ ................... DE] 7E] .................... ................... ~C D C 7711 El .................... 11 C 11Ci 7 F7 ~ .................... ~C C7C El Q ~ ~7G 11® El C ~ .................... .................... LI C El E-1 7Ci ~ ETS euestionnaire and description of exposure variables

Spain: Spanish Ministry of Health (Ref. 89002300) Sweden: Swedish Match (8913/9004/9109/9217); Swedish Environmental Protection Agenc,y (5330071-1) UK: Imperial Cancer Research Fund; Department of Health; Department of the Environment; European Commission We thank the following persons for their contribution to the study in the different centres: IARC: J. Siemiatycki, Lyon France: C. Schrameck, J. Azorin, P. Baideyrou, J.P. Battesti, J. Benoit, J. Bignon, F. Blanchon, J.J. Bonerandi, C. Brambilla, J.L. Breau, J.M. Brechot, J. Briere, J.M. Brisset, C. Buffet, G. Cathelineau, Y. Chapuis, J.P. Chevrei, J.P. Droz, L. Dubertret, F. Dubois, F. Fekete, P. Girard, C. Gisselbrecht, D. Grunenwaid, A. Hirsch, V. Izraei, A. Jardin, J.P. Kleisbauer, J.A. Krivitzkv, A. Laugier, T. Le Chevaiiier, F. Mal, F. Mazas, C. Menkes, F. Mignon, B. Milleron, E. Modigliani, R. Modigliani, P. Morel, J.F. Muir, J.Y. Nordin, J. Paoiaggi, J.B. Paolaggi, R. Pariente, S. Pretet, A. Puissant, J. Roussy, J.C. Sarles, B. Sastre, J. Sauvaget, G. Schaison, P. Testas, J. Tredaniel and D. Valeyre, Paris Germany 1: W. Hartmann, H. LOllig, K. Eberhardt, H.H. Jend, F.K. Kossling, K. Brandt and S. utadtler in Bremen; W.J. utelter, H.J. Becker, E.O.M. Hassenstein, E. Marz and W. Rosch in Frankfurt; and K.-M. Muller in Bochum Germany 2: G. Dingerkus in Wuppertal; N. Konietzko in Essen; Zeidler, Blessing, Brockmann and Seel in Koin; G. Sybrecht and Remberger in Homburg; U. Cegla in Bad Ems; R. Schubotz in Mayen; H.-J. Stein, W. Lenz and Schafer in Koblenz; E. Hugl in Andernach; H.G. Straaten, Mausie, Uhl, Hinkeidey and Hennekeuser in Trier; Macha, Kunze and Brightman in Hemer; Habich in Kutzenberg; Boleskei, Wunsch and Mittelmeier in Nurnberg; M. Gerken, Siemon and von Bultzingsiowen in Donaustauf; K.-M. Muller, Morgenroth and Burger in Bochum; Remmele in Wiesbaden; Zimmermann in Coburg; Korb and Gietl in Weiden; and Rockiein in Regensburg Germany 3: J. Heinrich and G. Wolke in Erfurt; Al-Zand, Weber and Drewnick in Zschadrass; Bonnet, Wiesner and Schmidt in Bad Berka; Matthiesen and Baudrexl in Coswig; Neudeck, Schuster and Urgan in Gera; Schmidt, Schaarschmidt and Habeck in Chemnitz; Haupt in Leipzig; Kunze in Dresden; and Schieck in Grimma Italy 1: Italy 3: S. Massacesi, M. Tedeschi and M. Artom, Turin F. Anatra and T. Trequattrini, Rome Portugal 1: Portugal 2: J. Maganita, E. Teixeira, R. Sotto-Mayor, M. Cancela de Abreu, H. Lucas, M.J. Melo and M.M. Crist6vao, Lisbon R. Neveda in Viana do Castelo; J.M. Calheiros in Porto; and A. Carvaiho, F.F. _ ~v Spain: Rodrigues, J. Moura e Sa and B. Parente in Vila Nova de Gaia C. Pallares, X. Fabregat, J. Roseilo, J. Estape, J. Planas, N. Malats and ~ i. Machengs in Barcelona; A. Barnadas and M.G. Esteve in Badalona; ~ 1. Martinez-Ballarin in L'Hospitafet de Llobregat; and A. Badia in Mataro :' Sweden: V. Agrenius, K. Svartengren and C. Svensson, Stockholm r1o UK: R. Doll, P. Silcocks and B. Thakrar, Oxford iv

2,3,1 Occasional smo Descriptive statistics of quantitative variables Descriptive statistics - Occasional smoking

Questionnaire on occasional dmoicing and environmental tobacco smoke (ETS) ETS from the spouse The person with whom the subject lives/lived in a marital type relationship. • Are you or have you ever been married or living with someone in a marital type relationship? Yes ..1; No ..2 L-1 If the subject has been married more than once, start with the first marriage and add additional lines for subsequent marriages. • Did your first spouse ever smoke? Yes..1; No..2 711 if NO, go to next spouse or next page. • Starting with your marriage (or the time you lived in marital status), I would like to know how much and how often you were exposed to his/her tobacco smoke at home, in vehicles or anywhere else indoors. I would also like to know whether the smoking habits of your spouse ever changed. Two types of changes need probing: 1. Change in spouse smoking habits: Type of product, amount smoked, change to non filter/fflter. 2. Change In subject's exposure to spouse: Moving house, spouse away from home. Use more than one line when spouse smoked more than one tobacco product in the same period. Start on first line with subject's age when he/she was first exposed. Did he/she smoke in your presence? What did he/ she smoke? How many Period cigarettes Cigarettes............1 (cigars, From To Cigars ..................2 pipes) age age Pipe .....................3 smoked (years) (years) Cigarette & pipe ..4 per day? Every day ..............1 Almost every day..z (5-6 days/week) 2-4 daysiweek....... 3 Rarely ...................4 por how many How many cigarettes hours/day were you (cigars,pipes) did exposed to tobacco he/she smoke smoke from your in your presence spouse on on average? average? Never ....................5 Weekdays Holidays Holidays Weekends Weekdays Weekends ' ®® F771 ED ®G EIE ~ 0 ~0(~ ~ ~ 071 ® 70 1:1 D 0 00 EIC El []r7, c, co ET_S puestionnaiand-de3rnntion of_exQOSUre variables_

I= M mQk mimmmrm IM m~ w @ n rmpL ~@ ~ mMIM® mu , IIMIM h1 l i `VlYlli~ W ~ ; ' ~~ ,; lil ll1lill~" ~~ulll~~~ll~ Fog, Mk IIIIIIIMNI ml u.Mmml ml 6V U 6 q E:9 e'"i-("

Table 2.1.5 Distribution of subjects by center and gender Cases ~ Controls I N TIC, N ~ !V men 14 18.2 ~ 23 ~ 15.2 France ! ~ - Germany 1 Women ~ Men Women 63 18 58 81.8 23.7 € 76.3 128 129 100 84.8 ` ~ 56.3 ' 43.7 Men 29 20.4 65 39.9 Germany 2 Women 113 79.6 I 98 ; 60.1 [ Men 10 32.3 1 14 26.9 Germany 3 I ~ Women 21 ' 67.7 38 73.1 wlen 8 ~ 20.0 7,03 1 46.6 ° Italy I ~ Women 32 ( 80.0 I 118 ± 53.4 Men ~5 15.8 ; 97 56.1 Italy 2 Women 16 84.2 ~ 76 43.9 Italy 3 i Men ~ Women 1 15 6.3 93.8 12 38 24.0 76.0 ~ Men 16 32.7 8 20.5 Portugal1 ' ' ~ Women 33 67.3 31 79.5 ~ Men 10 s 30.3 E 17 32.1 Portugal 2 Women 23 ~ 69.7 f 36 67.9 Men 6 8.5 13 8.2 Spain ; Women 65 91.5 146 91.8 en wt e n 23 32.9 36 32.1 Sweden I Women 47 67.1 ~ 76 67.9 ~ Men 3 11.5 ~ 14 4 10.0 ~ United Kingdom Women 23 ~ 88.5 i 126 90.0 Men 141 F 21.7 531 f 34.4 Total ~ i Women 509 ~ 78.3 ~ 1011 65.6 ~

Questionnaire on occasional smoking and environmental tobacco smoke (ETS) 9 ETS at the workplace • i would like to know if you ever worked in an indoor place where you were exposed to tobacco smoke. Yes..1;No..2 El If NO, go to next page. If YES, rill in one line for each job in which the subject was exposed to ETS. Would you say that the place Exposure to ETS was usually: Job number From To Very smoky.....1 (refer to age age Fairly smoky ...2 job history) (years) (years) A little smoky ..3 ® ......... M ......... 11 .......... 17 .......... ~ •......... ~ ~ .......... How many hoursiday on average were you exposed to tobacco smoke at work, including time spent at the canteen or during breaks? How many days per week were you exposed to tobacco smoke at work? Approximately how large was the room? Small (under 40 m2) ...'i Medium (40-80 m2).....2 ! arge (80 -200m2) .......3 Very large (>200 m2) ..4 ®71 0 ®71 ~ ~ OC ~ ~ 771 ~ ~ 71 i.u ~ ~ C ~ ~ -~ ~ ~ ~ 71 El C ^ ~ ~ DII : L I

2.3.2 Childhood OM estimates (819 ~~r~ ~ Risk estimates - Childhood 0-18 years

Questionnaire on occasional smoking and environmental tobacco smoke (ETS) Residential history • I would like to know about all houses/residences where you lived for longer than two years, starting with the home where you were born. Period From To age age Town, (years) (years) village County (if abroad, the country) What is/was the principal means In your of cooking? opinion, is/was it a rural or Gas ................... 1 urban area? Electricity ..........2 Coal stove ........3 Rural .... I Wood stove ......4 fJrban...2 Other (specify)..5 What is/was the principal means of heating? (no more than 2 methods for each residence) Central heating'............ 1 Gas stove or similar.....2 Wood stove .................. 3 Coal stove ....................4 Kerosene or other fuel .5 Other (specify) .............6 ~ 171 ................. C ~ ................. El 7-1 .................. El 1:1 .................. El El ................. El El .................. ~ 0 : ................. El ® .................. El El .................. 'Uentral heating: a system for which there is no combustion unit in the fiving or sleeping area of the house. ETS questionnaire and description of exposure variables

Questionnaire on occasional smoking and environmentai tobacco smoke (ETS) ETS in vehicles • Have you ever (lifetime) traveled daily or at least a couple of times per week by car, train, bus or another enclosed vehicle which was smoky (or where you could at least smell tobacco smoke) most of the time? Yes..1;No..2 El if NO, go to next page. if YES, please state from what age to what age, on which t,vpe of vehicle and for how many hours per day or per week you were exposed to tobacco smoke. Type of vehicle Period From age (years) To age (years) Car ....................... 1 i rain ....................2 Bus/tram ..............3 Other (specify).....4 DE, C1® ~ .................. ~~ ~0 ~ .................. 71E] a® ~ .................. -EIC ®® i .................. 1111 110 ~ .................. E= EIF I DC ®E1 C .................. ~ .................. - ®EI ®Ell ~ .................. ®~ ®® ®® ®® LI .................. 1:1 .................. How many hours per day or week were you in this vehicle while you were exposed to smoke? Per day Would you say that the vehicle was usually: Very smoky...... I Fairly smoky .... 2 A little smoky... 3 Exposure already covered, e.g. occupational and from spouse should be excluded. Exposure during daily commuting to work should be reported in this section. ETS auestionn ire and_deGaiotion of exoosure variahlas__

2,232 Childhood Owl 00 virs zff Descriptive statistics er" quantitative variables Descontive statistics - Childhood_0-1 8_vears___ __

Table 2.'! .8 Distribution of subjects by educational level, center and gender Men ~ Women E Both genders ~ Cases Controls Cases ! Controls i Cases Controls N °r'o N °lo N So lV `/o ( !V °lo N j au Low education 1 7.1 . 7 11.1 7 5.5 8 10.4 7 4.6 France Middle education 1 7.1 5 21.7 23 ~ 36.5 51 39.8 24 ~ 31.2 1 I 56 37.1 Hi9heducation 5 35.7 8 34.8 9 14.3 20 15.6 14 18.2 1 28 18.5 Missin9 50.0 43.5 24 38.1 50 39.1 31 40.3 60 39.7 Low education 14 '7.8 90 1 69.8 39 67.2 69 1 69.0 53 69.7 159 69.4 Gettnany 1 Middle education 3 1 16.7 15 11.6 ~ 16 ~ 27.6 23 23.0 ~ 19 . i 25.0 38 16.6 High education 1 ~ 5.6 24 18.6 3 5.2 1 8 8.0 4 5.3 32 14.0 hlissi ; . ; ~ Low education 16 55.2 1 40 61.5 92 81.4 59 60.2 108 76.1 99 60.7 Middleeducation 9 31.0 7 10.8 10~ 8.8 24~ 24.5 19 13.4 31 19.0 Gerrnany2 Hkgh education 4 13.8 ~ 18 27.7 ~ 11 I 9.7 15 15.3 15 10.6 331 20.2 ~ Missi ' .; ` LaveducaGon 91 90.0 81 57.1 19 90.5 29 76.3, 28 90.3 37 71.2 y Getman 3 Middle education 1~ 10.0 4 1 28.6 2 9.5 3 7.9J 3 9.7 ' 13.5 Higheducat~n M ssln~ :1 2~ 14.3 I ~ 6 , 15.81 .I I 8 15.4 Low education 2 25.0 1 401 38.8 19 59.4 651 55.1 21 52.5 105 47.5 Ilal 1 Middle eduration ~ 1 12.5E I 26 25.2 10 31.3 29 24.6 11 27.5 55 24.9 y Hgheducation 4( 50.01 371 35.9 31 9.4 20 16.9 7 17.5 57 25.8 1 Misslnq 1 12.5 ~ 1 4 3.4 1 2.5 4 1.8 Loweduc~tron 2 66.7 291 29.9 8~ 50.0 35 46.1 10 52.6 64 37.0 Middle education i .; 18 18.6 2i 12.5 10 13.2 d 10.5} 28 16.2 ifal 2 y i High education j 23 1 23.7 1 f 6.3 1 8 10.5 1 5.3 I 31 17.9 I Missi~_ ng 1~ 33.3 . 271 27.8 5 31.3 23 30.3 6 31.6 50 28.9 ( Low education ., 6 50.0 13 86.7 21 55.3 131 81.3 27 54.0 Italy 3 ~ Middle educa(ion ~ I 2, 16.7I 1 6.7 11 28.9 1 6.3 13 26.0 ~ High educaGon 1~ 100.0 ~ 4 j 33.31 11 6.7 6 15.8 2 12.5 10 20.0 Missing - .~ l ~ LcweducaUon , Potiuqal 1 ~ l education n j ! e I High edu ! I f ~ Missina 16 100.0 81 100.0 33 100.0 31 100.0 49 100.0 39 100.0 Low education Pottugal 2 ~ Middle education High educatwn 1 i • i ~ ~ I ~ Missino 10 100.0 17~ 100.0 23 100.0 361 100.0 33 100.0 53 100.0 Low education 4 66.71 10 76.9 60 92.3 131 89.7 64 90.1 141 88.7 ~ M~dlaeducat~n ~ ~ 2 ;5.4 1 1.5 8 5.5 1 1.4 10 6.3 Spain ~ Hi9h education 2~ 33.3 ~ 7.7 3 4.6 , 4 2.7 5 7.0 I 5 3.1 ~ Mtssina j 3 2.1 1 ;.4 3 1.9 Low education . ; I ~ SWeden Middle education ' I ~ High education ~ i .; { Missing 23 100.01 361 100.0 47 100.0 761 100.0 70 100.0 112 100.0 Low educat;on ~ . ; • 1 • I UnitedKingdom Middleeducation High education 1 2 33.3j 66.7i 7~ 71 50.0 50.0 15! 8i 65.2 34.8 67 59 53.2 46.8 16 10 61.5 38.5 74I 66 52.9~ 47.1/ Missin Law education 48 34.0 I 223 42.0 ~ 257 50.5 416 41.1 305 46.9 639 41.4 ~ Middleeducation 161 11.31 86 16.2 80 15.7 226 22.4! 96 14.8 312 20.2~ Total i ft educa6on 19 13.5~ 124 23.4I 39 7.7 146 14.4 58 8.9 270 17.51 Missing 58 41.1 981 18.5~ 133 26.1 223 I 22.1 191 29.4 321 20.81

E OSTR Ever tried to smoke Casas ) Con1ro13 ) OR(1) 95x CI ) d65 958 1.00 151 1301 0.49 ( 0.26- 0.89)1 Excludid/Trind! 1701 454 ALL CENTERS WITH EDUCATIONAL LEVEL AND TYPE OF RESIDENCE Non eXpOSetl 332 745 7.00 Exposed 13 111 0.51 ( 0.26- 0.99) fxcludad/Trendl 1591 4821 ALL CENTERS WITH D(ETARY DATA Non axpotad 362 670 1.00 32 0.53 ( 0.21- 1.30) E%pOStd 7 OR(2) 95% CI ( OR(3) 95% Ct ) OR(4) 95X CI ( OR(5) 95% CI 1.00 1.00 1.00 1.00 0.54 ( 0.29• 1.00)1 0.54 ( 0.28. 1.06)1 0.48 ( 0.26- 0.90)1 0.53 ( 0.22- 1.32) 7.00 1.00 1.00 1.00 0.51 ( 0.26- 0.99)i 0.54 ( 0.28- 1.06) 0.49 ( 0.25- 0.98) 0.52 ( 0.20- 1•39)( E € 1.00 1.00 1.00 1.00 l 0.60 ( 0.24- 1.49) 0.57 ( 0.21- 1•54)1 0.56 ( 0.23- 1.40) 0.53 ( 0.22- 1.32)~ Excludad/Tnnd 140 3641 FRANCE lion exposao Exposed 44 71 1.00 1.00 1.00 1.00 1.00 0 2 0.00 ( 0.00•99.99) 1 0.00 ( 0.00-99.99) 0.00 ( 0.00•99.99) 0.00 ( 0.00-99.99) 0.00 ( 0.00•99.99)~ Exclud.d~rr.nd 33 784 I E ( GERMANY 1 Non oxposao 63 177 1.00 1.00 1.00 1.00 1.00 ~xposad 0 4 o.oo ( o.oo•ss.9s) 0.00 ( 0.00-99.99) 0.00 ( 0.00-99.99)~ 0.00 ( 0.00•99.99) 0.00 ( 0.00•99.99)~ tttl Excluded/Trtnd 13 48 Non exposeo 137 ~xcludad/Trondj 5 GERMANY 3 Non expottd 30 Excluded/Trend1 1 ITALY I Non exposad 22 Exposed 6 fxcluded/Trend 12 1471 1.00 f6 491 1.00 3 1.00 1.00 1.00 ~ 1.00 96 1,00 1.00 1.00 ( 1.00 58 0,51 (, 0.19- 1.39) ( 1 0.55 ( 0.20- 1.52) 0.61 ( 0.21- 1.75) ~ 0.47 ( 0.16- 1.39) f f 67 - ITALY 2 Non exposed 13 111 1.00 1.00 ; 1.00 Exposed 2 34 0.46 ( 0.09- 2.40) 0.23 ( 0.03- 1.76)~ 0.35 ( 0.03- 4.48) fxcludcd/Trend~ 4 28 ~ ITALY 3 Non exposad 1.00 Expotad 0.14 ( 0.01- 1.71) sxcluded/Trtndl PORTUGALI Non exnosto Exposad ~cluded/rrend POR7UGAL2 Non exposed 21 391 1.00 1.00 Excluded/rrsnd( 121 14 SPAIN Non expoteo 48 98 1.00 1:00 ~ 1.00 Exposed 4 12 0.66 ( 0.19- 2.32)1 0.76 ( 0.21- 2.73)~ 0.82 ( 0.20- 3.26) Cxcluded/Trend 9 I 49 1.00 ( ~ 0.48 ( 0.09• 2.55)~ 1.00 0.32 ( 0.05- 1.99) 1.00 0.63 ( 0.09- 4.56) 1.00 0.00 ( 0.00-99.99) 1.00 7.00 1.00 0.70 ( 0.19- 2.51)~ 0.72 ( 0.20• 2-55) Non expotao 20 40 1.00 1.00 ( 1.00 1.00 Exp03ad 1 0 99.99 ( 0.00•99.99) 99.99 ( 0.00-99.99) ~99.99 ( 0.00-99.99) 99.99 ( 0.00-99.99) Excludtd/Trand~ 49 72 UNITED WNGDOM Non ®xposed Exposed 13 :1 1.00 1.00 1.00 1.00 1.00 0 1 0.00 ( 0,00•99.99) 0.00 i 0.00•99,99) 0.00 ( 0.00-99.99) 0.00 ( 0.00-99.99) 0.00 l, 0.00-99.99) Excludad/rrandl ;3~ 68 ~ E ~ (1) Model Indude sex, center, sex•canter and age (2) Modej fndude sex, center, se%'Center, age and proportion of residential type in the last 35 yrs (REUP) (3) Model Include sex, center, sex•center, age, proponion of residential type in the last 35 yrs (REUP) and educational level (EDUC) I4t Mode! I+tck4e 9ex, CGnter, seX'Crnte , aS'e and durrtron of ~posure to II3t A aSentS (OCIAY) (5) Model )nC7ude Sex, center, sex•center, age and frequency consumption oi vegetables (VEGE) 7 € Risk estimates - Occasional smoking

E ®Soc Ever smoked occasionally 438( 0.94 ( 0.73- 1.21)! 1.01 ( 0.78- 1.32)1 1.01 ( 0.74- 1.40)f 0.95 ( 0.74- 1.23)( 0.85 ( 0.64- 1.13) Excluded/Trend[ 01 01 ALL CENTERS WITH EDUCATIONAL LEVEL AND TYPE OF RESIDENCE 868 1,00 1 1.00 1 1,00 1.00 1.00 292 0.98 ( 0.71- 1.34)1 0.98 ( 0.72- 1.35)1 1,01 ( 0.74- 1.40) 0.98 ( 0.71- 1.36) 0.87 ( 0.61- 1.24) dxxcluded/Trendl 671 !78 ALt. CENTERS WITH DIETARY DATA Non oxposed Exposed FRANCE 074' 128. I _ Controls I OR(1) 95% CI I OR(2) 95% CI ; OR(3) 95% Cl ( OR(4) 95•f. CI ( OR(5) 95•. Ct 11041 1.00 1.00 1•00 ( 1.00 1.00 715 321 Excluded/Trendl 71 20 Non oxposed 44 73 1.00 1.00 1.00 1.00 1.00 Exposed E 33 78 0.67 ( 0.38• 1.19) 0.84 ( O.a4• 1.60)~ t.21 { 0.$2• 2.81 ) 0.67 ( 0.37- 1.19) 0.68 1 0.38- 1.20) Fxcludad/Trendl 0 0 ~ ~ Non exposed 63 181 1.00 1.00 1.00 1.00 1.00 Exposed l 131 48 i 0.89 ( 0.43- 1.83) E 0.84 { 0.38- 1.86)~ 0.80 ( 0.36- 1.79) 0.85 ( 0.41- 1.80) 0.94 ( 0.45- 1.94) Excluded/Trend 0 1 01 ~ Non exposed 137 147 1.00 1.00 1.00 1.00 1.00 Exposed 5 16 0.36 ( 0.12. 1.04) 0.35 ( 0.12- 1.02) 0.36 { 0.12- 1.03) 0.36 ( 0.12- 1.03) 0.29 ( 0.09- 0.92) E.xcludod/Trendl 0 01 Non lxpdi®tl 30 49 1.00 1.00 1,00 1.00 1.00 Exposed ~ 1 ~ 3 0.48 ( 0.04- 5.22) 0.45 ( 0.04- 5.28)f 0.38 { 0.03. 5.48) 0.53 ( 0.05- 5.89) 0.37 ( 0.03- 4.24)i Excluded/frend l ®! 0 ITALY I Non cxposod Exposed Fxcluded/Trend ITALY 2 Non exposetl Exposed @xcluded/Trend ITALY 3 Non exposed Exposed s'xcluded/Trend PORTUGALi Non exposea Exposed Exc1 uded/Trend PORTUGAL2 Non exposed Exposed Exc1 uded/Trend SPAIN Non e%posetl Exposed E)rc1 uded/Trend SWEDEN Non exposed Exposed excl uded/Trend UNITED KINGDOM 155 66 1.00 1.30 ( 0.60• 2.83) 1.00 1.22 ( 0.53- 2.80) 01 0) f 15 146 1.00 1.00 4 27 2.02 ( 0•56• 7.38)I 1.58 ( 0.35- 7.24) 0 15 6( 1,00 4` 1.60 ( 0.12-20.63) ! 0! 01 42 7 21 12 40 13 01 Oj 1.00 2.78 ( 0.88• 8.81) 1.00 1.50 ( 0.05-42.32) 1.00 2.74 ( 0.77- 9.82) 57 123 1.00 1.00 14 36 0.85 ( 0.41• 1.75) 0.96 ( 0.46- 2.02) 0i 01 40 72 21 49 0 1.00 1.00 I 1.54 ( 0.78- 3.04)~ 1.50 ( 0.76- 2.94) 111~ ~ 1.00 1.36 ( 0.58- 3.21) 1.00 1.52 ( 0.68• 3.37) 1.00 T1•00 3.11 t 0.56-17.37)~ 1.85 ( 0.49- 6.93) Ilf 1 1.00 0.90 ( 0.03•27.22) 1.00 ( 1.00 ( 1.89 ( 0.13•26.61)1 1.75 ( 0.12-24.720_- > .00 ~ 2.59 ( 0.81- 8.31) 1.00 1•00 1.03 ( 0.48- 2.20) 0.82 ( 0.39- 1.72) ! 1.00 0.89 ( 0.43- 1.84) Non exposed 13 '2 1.00 1.00 1.00 1.00 1.00 Exposed 13F 68 1.06 (, 0.45- 2.50) 1.11 ( 0.46• 2.66) 1.10 ( 0.46- 2.65) 1.10 ( 0.45- 2.68)~ 1.03 ( 0.43- 2.44) &cluded/frendi 0~ 0 (1) Model Include sex, center, sex'center and age (2) Modd Mdudo s¢x, center, sex'center, age and proport on of residential type in the last 35 yrs (REUP) (3) Model Indude sex, center, sex'oenler, age, proportion of residential type in the ast 35 yrs (REUP) and eduqtional level (EDUC) ,4j h(odct (n6lQdQ sCx, cen(er, scX•cGn(er, age and Gura(wn of expasure to hst A agents (OCLAY) (5) Model Include sex, centcr, sex'center, age and frequency consumption of vegetables (VEGE) 28 12 Risk estimates - Occasional smoking

E OSTR Ever tried to smoke MEN ONLY @XpOa@tl !! 93 294 Expoa@d ~ 3 64 L.wl of osuro Cases Controls Non 5xcluded/Trendl Non 45~ >73 WOMEN ONLY e%p0a@0 372 664 EXpoa@d 12 66 OR(1 95% CI OR(2) 95% Cl OR(3 95X CI ) OR(4 95% CI OR(5 95% CI € 1.00 1.00 1.00 1.00 1.00 0.34 ( 0.08- 1.43) 0.39 ( 0.09• 1.66) 0.46'( 0.10- 2.07)~ 0.32 ( 0.08- 1.34) 0.77 ( 0.10- 6.20) ~ ~ 1.00 1.00 1.00 1.00 1.00 0.53 ( 0.27- 1.04) 0.60 ( 0.30- 1.18) 0.58 ( 0.28- 1.23) 0.53 ( 0.26- 1.07) 0.49 ( 0.18- 1.35) Excludad1rrendj 125 281 POPULATION BASED STUDIES Non exposed 285 620 1.00 1.00 1.00 1.00 1.00 Exposed 9 96 0.56 ( 0.26. 1.23)1 0.58 ( 0.26- 1.27) 0.57 ( 0.23- 1.39) 0.54 ( 0.24- 1.24) 0.68 ( 0.07- 6.69) ~ { € ~xcluded/Trond 84 234 HOSPITAL BASED STUDIES Non exposed 167 267 1.00 1.00 ` 1.00 1.00 1.00 Exposed 8 6 33 0.42 ( 0.16- 1.10) 0.54 1 0.20- 1.46)~ 0.55 ( 0.20- 1.53) 0.43 ( 0.16- 0.55 ( 0.20- 1•50)~ yxcluded/rrend~ ;3~ 152 ! YIRTHOt1T OCCASIONAL SMOKERS Non @Xpoaed 465 958 1.00 1.00 1.00 1.00 1.00 Exposed 15 130 0,49 ( 0.26- 0.89) 0.54 ( 0.29- 1.00) 0.54 ( 0.28- 1-06) 0.48 ( 0.26- 0.90) 0.53 ( 0.22• 1.32) c'xcluded/Trend 6 ~ 16~ AGE t55 YEARS Non expoa@a 111 196 1.00 1.00 € 1.00 1.00 9.00 Exposed 3 27 0.32 ( 0.08- 1.26) 0.44 ( 0.10- 1.85)~ 0.45 ( 0.10- 1.97) 0.21 ( 0.04- 1.03) 0.27 ( 0.03- 2.74) Excluded/rrendl 51 138~ ( 9 AG E 55-C4 YEARS Non eXpoaetl t44 Expoaed 6 348 1.00 1.00 1.00 1.00 1.00 54 0.47 ( 0.16• 1.37) 1 0.48 ( 0.16. 1.42)) 0.55 ( 0.16- 1.91)I 0.51 ( 0.17- 1.52) 0.98 ( 0.18- 5.32) l € cxcluded/Trend 60 150 ~ ~ ~ AGE 65+ YEARS Non expos@d 210 Exposed 6 ~xcluded/Trendl 594 HISTOLOGICALLY CONFIRMED DIAGNOSIS 414 1.00 1•00 49~ 0.64 ( 0.25- 1.68)~ 0.66 ttt ( 166! Non exposed 44a 658 EXpOaed 15 130 i Excluded/Trendl SQUAMOUS CELL CARCINOMA Non exposed Exposed 4541 1.00 0.65 ( 0.16- 2.62) 1 F 0.49 ( 0.26- 0.91)1 0.54 ( 0.22- 1.33) ~ 77 a58 1.00 1•00 1.00 1.00 1.00 5 130 1.00• 1.00) 1.74 ( 0.58- 5.16) 1.31 f 0.34- 5.06)~ 1.31 ( 0.34- 5.06) 1.49 ( 0.31- 7.16) Excluded/Trend ~ 27 ~ 454 ~ SMALL CELL CARCINOMA Non exposed Exposed 56 95s 1.00 1.00 ' 1.00 1.00 1.00 0 130 0.00 ( 0.00•99.99) 0,00 ( 0.00-99.99) 0.00 ( 0•00•99•99)~ 0.00 ( 0•00•99•99) 0.00 (, 0.00-99.99) ttti Excluded/Trend 14 454I ADENOCARCINOMA Non exposeo Exposed €xcluded/Trend 454 1.00 1.00 ( 0.32 ( 0.09- 1.12) 0.29 ( 0•04- 2.39)I Excluded/rrendl 291 4541 ~ ~ a755G OF LIFESPAN IN RURAL AREA OR INTERMEDIATE CITIES Non exposeo 197 376 1.00 1 1.00 1.00 1.00 1.00 Exposed ~ 0 151 0.00 ( 0.00-99.99)! 0.00 ( 0.00•99.99) 0.00 ( 0.00-99.99) 0.00 ( 0.00-99.99) 0.00 ( 0.00-99.99) € Excluded/Trendl 59 184 ~-7590 OF LIFESPAN IN URBAN AREA r Non @XpOS@d 156 1.00 1.00 1.00 12 Exposed ~ 0.57 ( 0.28- 1•19) 0.57 ( 0.27- 1.18) 1•00 ( 0.37• 2.71)i .xcluded/Trendi 751 199 (1) Model tnelude sex, center, sex'centerand age (2) Model Include sex, e0nter, sex'center. age and proportion of residential type in the last 35 yrs (REUP) (3) Model Indude sex, center, sex'center. age, proportfon of residential type in the last 35 yrs (REUP) and educational level (EDUC) (4/ MOder (nctuda scx, cencer, sex-csncer, age and durati0n of exposure to list A agencs (OCLAIn (5) Model include sex, center, sex'center, age and frequency consumption of vegetables (VEGE) 1631 1.00 0.25- 1.72)1 0.63 ( 0.22- 1.82)! 0.68 ( 0.26- 1.79) 3iSL~est€maie_c- O~caeinnal cmnkinn

E-OSOC `ver smoked occasionally MfiN ONLV axposurc Lwal of Non exposed Exposed Cases 1 Controls tOR 1 95% CI OR(2) 95% CI OR(3 95% CI ( 5R 4 95% CI OR 5 95% CI ( 97 359 1.00 1.00 1.00 1.00 1.00 44 172 0.61 ( 0.37- 1.01) 0.72 ( 0.42- 1.23) 0.51 ( 0-25- 1.06) 0.59 ( 0-36• 0.99) 0.48 ( 0.26- 0.89) Exc1 uded/Trend 0 0 Y`lOMEN ONLY Non QxposQd Exposed 389 120 745 266 Excluded/Trendl 01 0 POPULAT10N BASED STUDIES Pon exposad 294 718 Exposed ( 84 232 1.00 1.10 ( 0.82- 1.47) 1.00 € 1.00 1.16 ( 0.85- 1.58)1 1.28 ( 0.89- 1.85) 1.00 y 1.00 1.13 ( 0.84- 1.52)If 1.03 € ( 0.74- 1.43 1.00 1.00 1.00 1.00 1.00 1.01 ( 0.71- 1.44) 0-98 ( 0.68- i.41) 0.92 ( 0.58- 1.46) 1-01 ( 0.71- 1.45) 0.89 ( 0.59- 9.36)~ Excluded/Trendl 0 0f HOSPITAL BASED STUDIES Non QxposQtl 179 314 Exposed 67 138 E Excluded/Trenrl~ 0~ 0 WITFIOUT OCCASIONAL SMOKERS Non exposed 486 1104 € Excluded/Trend 0~ 01 1.00 ~ 1.00 1.00 1.00 i 1.00 0.86 ( 0.58• 1•26) EEE 1.08 ( 0.70- 1.66) 1.08 ( 0.64- 1.84) 0.88 ( 0.60• 1.30) 0.77 ( 0.50- 1.20) 1.00 1.00 1.00 1.00 1.00 € AG€ t55 YEARS Non Qxpoaad 116 226 1.00 1.00 1.00 1.00 1.00 1 Exposed 49 135 0.66 ( 0.41- 1,06) 0.74 ( 0•44• 1.26) 0,78 (, 0.41- 1.46) 0.66 ( 0.40- 1.08) 0.69 ( 0.40- 1.20) ~ Excluded/Trend 0 0 i t t ~ ~ AGE 55•b4 YEARS Non Qxposetl Exposed i52 405 1,00 1.00 ( 1.00 1.00 1.00 58 147€ 1.49 ( 0.95- 2.33) 1.47 (, 0.92- 2.35) 1.20 ( 0.69- 2.08)~ 1.56 ( 0.99- 2.46) 1.32 ( 0.78- 2.23) Excluded/Trendl 0 01 AGE 65+ YEARS Non Qxposeo Exposed 218 57 Excluded/Trend[ 01 HISTOLOGICALLY CONFIRMED DIAGNOSIS 1.00 1.00 1.00 ( 1.00 0.90 ( 0.60. 1.35) 0.96 ( 0.63• 1.47)1 1-05 ( 0.62- 1.77)I 0.91 ( 0.61- 1.37) Non exposed 470 1104 1.00 1.00 1.00 1.00 1.00 ExpOSed 157 438 ~ 0.94 ( 0.73- 1.2')~ 1.01 ( 0.77- 1.33)' 1.02 ( 0.74- 1.41) 0.95 ( 0.74- 1.23) Ilj 0.85 ( 0.64- 1.14) Excluded/Trendl 0~ 01 ! ~ € SQUAMOUS CELL CARCINOM A Non Qxposltl "2 1104 1.00 1.00 1.00 1.00 1-00 Exposed 27 438 1.20 ( 0-71• 2.03) 1.30 ( 0.74- <^-27)~ 1.14 ( 0.58- 2.24) 1.33 ( 0.78- 2.26) 1.03 ( 0.55- 1.91) ~ Excluded/Trend o 0 ~ ~ SMALL CELL CARCINOMA iion exposea 56 1104 1,00 1.00 1.00 1.00 1.00 Exposed ( 14 438 1.05 ( 0.53• 2.08)~ 0.92 ( 0.44- 1.90)~ 0.91 ( 0.41- 2.00) I 0.91 ( 0.44- 1.86) 1.03 ( 0.51- 2.11) Excluded/Trendj 01 0 ADENOCARCINOMA Non QXp038tl 246 1104 1,00 1.00 1.00 1 1.00 E 1.00 1 Exposed 1 87 438 0.90 ( 0.65• 1.25) 0.98 ( 0.69- 1.38) 0.97 ( 0.63- 1-50)1 0.95 ( F 0.69- 1.32)1 0.80 ( 0.55- 1.15)~ Excluded/Trendi OTHER 0 0 1 ( Non exposetl ~ 86 1104! 1.00 1.00 1.00 1.00 1.00 E Exposed € 29 4381 0.76 ( 0.46- 1.26) 0.96 ( 0.57- 1.61) 1.05 ( 0.57- 1.94) 0.73 ( 0.44- 1.22) 0.79 ( 0.45- 1.38) I F €( ~ €xcluded/Trendf 01 01 ~75'ti OF LIFESPAN IN RURAL AREA OR INTERMEDIATE CITIES Non OxpOSQO 98 1 393 1 . 00 1 00 1.00 1.00 1.00 € Exposed 58 182 81 ( 0.53- 1.22) 0. 0.81 (, 0.53- 1.22) 0.78 ( 0.47- 1.29)~ 0.80 ( 0.53- 1.22) 0.68 ( 0.43- 1.06)~ Excluded/Trend 0 0 Non QxpofQO 171 321 1.00 1.00 1.00 1.00 1-00 Exposed 73 190 1.25 ( 0.85- 1.83) 1.25 ( 0.85- 1.83) 1.19 ( 0.75• 1.89)1 1.25 ( 0.84- 1.84)~ 1.24 ( 0.79- 1.96) E,rcluded/Trend 01 Ol [ I ~ ( (1) Model /ndude sex, center, Sex'eenterand age (2) Model kidOde sex, conter, sex'center, age and proportion of residential type in the last 35 yrs (REUP) (3) Modet Include sex, oonter, sex'canter. age, proportion of res,dential type in the Last 35 yrs (REUP) and educetionat level (EDUC) {4j rWodef r`nctudc sex, r.anter, sex'ccnfeG sgs and duration o( exposure to list A a9enes (CCIAY) (5) Modet include sex, center, sex'center, age and frequency amsumplion of vegetables (VEGE) Risk estimates - Occasional smoking

Table 2.1.9 Distribution of cases by histological type, center and gender Men cases Women cases i Both genders ~ N i •o N % N % I Squamous cell carcinoma 1 I 7.1 8 12.7 9 11.7 Small cell carcinoma , . ., 7.9 5 j 6.5 France € Adenocarcinoma 7 50.0 40 63.5 47 61.0 ~ ; Other 6 42.9 10 15.9 16 20.8 Unknown . i i 1 E Squamous cell carcinoma 3 16.7 9 15.5 12 15.8 Small cell carcinoma 4 22.2 16 27.6 20 26.3 ~ Germany 1 Adenocarcinoma 5 27.8 24 41.4 29 38.2 Other 6 33.3 ~ 9 15.5 15 19.7 F Unknown -~~ - Squamous cell carcinoma 4 I. 13.8 ~ 19 16.8 23 16.2 ~ Small cell carcinoma 2 ; 6.9 ~ 17 15.0 19 13.4 ~ Germany 2 € Adenocarcinoma 19 65.5 j ~ 61 54.0 80 56.3 Other 4 13.8~ 16 14.2 20 14.1 i Unknown j ' ; Squamous cell carcinoma 5 50.0 I 4 19.0 9 29.0 Small cell carcinoma 5 50.0 I 5 23.8 , 10 ~ 32.3 Germany 3 ` Adenocarcinoma . 11 52.4 11 I 35.5 ~ Other . . 1 4.8 1 j 3.2 Unknown ~ ~ ? Squamous cell carcinoma 1 ~ 12.5 5 15.6 6 15.0 ' Small cell carcinoma . . 1 3.1 1 2.5 Italy 1 Adenocarcinoma 3 I. 37.5 18 56.3 21 52.5 Other 4 1 50.0 8 25.0 12 30.0 ~ ~ Unknown . ; € ! Squamous cell carcinoma 1 I 33.3 5 31.3 6 31.6 ~ ~ Small cell carcinoma . E . j 1 6.3 1 5.3 Italy 2 ~ Adenocarcinoma 1 33.3 I 6 37.5 7 36.8 ~ Other 1 I 33.3 1 3 18.8 4 21.1 Unknown 1 6.3 1 5.3 ; Squamous cell carcinoma . i 1 6.7 1 6.3 Small cell carcinoma ~ 6.7 1 6.3 Italy 3 i Adenocarcinoma 1 100.0 I 7 46.7 8 1 50.0 I Other . . j 6 40.0 6 37.5 Unknow n i ; Squamous cell carcinoma 4 25.0 11 33.3 15 30.6 Small cell carcinoma I . . Portugal 1 ; Adenocarcinoma 8 1 50.0 18 54.5 2 6 .1 53 Other 3` 18.8 4 12.1 i ~ 14.3 Unknown -~ 1 I 6.3 ! 1 2.0 ® Squamous cell carcinoma 2 20.0 2 i 8.7 4 i 12.1 Small cell carcinoma . . 2 ~ 8.7 ~ 2; 6.1 Portugal 2 I Adenocarcinoma 4 40.0 7 ~ 30.4 11 I 33.3 I Other . . . j i Unknown 4 40.0 12 I 522 16 j 48.5 Squamous cell carcinoma . 11 16.9 11 15.5 ! Small cell carcinoma 1 16.7 2':. 3.1 3 I 4.2 ~pain ~ Adenocarcinoma 4 66.7 39 I 60.0 43 60.6 ? Other ~ 1 ~ 16.7 13 I 20.0 14 I 19.7 Unknown Squamous cell carcinoma 1 4.3 6 i i2.8 7 ~ 10.0 j Smal( cell carcinoma . . 2' 4.3 2 2.9 Sweden Adenocarcinoma 19 82.6 26 55.3 45 64.3 Other 3 13.0 13 ~ 27.7 16 22.9 Unknown ~ Squamous cell carcinoma 1 6 26.1 6 23.1 Small cell carcinoma i j 33.3 ~ 5 21.7 6 ~ 23.1 United Kingdom Adenocarcinoma 1 j 33.3 ~ 4 17.4 5 i: 19.2 ~ Other 1 j 33.3 3 ',3.0 4 ~ 15.4 ~ Unknown ., . 5 21.7 5 19.2 Squamous cell carcinoma 22 , 15.6 ( 87 17.1 109 16.8 ; Small cell carcinoma 13 9.2 ~ 57 11.2 70 10.8 Total i Adenocarcinoma 72 51.1 261 51.3 333 51.2 i! Other 29 20.6 86 16.9 115 17.7 ~ ! Unknown 5 3.5 18 3.5 23 3.5 ~

E _CIEV Childhood Q-18 yrs, ever exposed Oas" 1 Controls j OR(•1) 95Y. Ci ) ORt2) 95% Ct 252 1 00 3891 1021~ 0,78 ( 0.64- 0.96]) 0.83 ( 0.66- 1.04) E f ~ fxcludid/Trsnd e 251 1 ALL CENTERS W1TH EDUCATIONAL LEVEL AND TYPE OF RESIDENCE Non eXpoaOd Exposed 350 7891 1.00 0.82 ( 0.64- ~ 1.00 1.06)! 0.83 ( 0.64- F €XCludrd/Trondj 741 1991 ALL CENTERS VNTN DIETARY DATA Non axp0aed 189 320 1•DO 1.00 1.00 1.00 1.00 Exposed 306 706 0.76 ( 0.60- 0.97)~ 0.80 ( 0.63- 1.03) 0.81 ( 0.61- 1.08) 0.77 ( 0.61- 0.98)~ 0.77 ( 0.61• 0.98)~ ` fxcludad/Trand 14 30 ~ ~ Non exposed 32 37 1.00 I 1.00 1.00 1.00 1.00 ) Exposed 44 114 0.45 ( 0.25- 0.82) 0.68 ( 0.35• 1.34) 1.12 ( 0.45- 2,82)~ 0.44 ( 0.24- 0.80) 0.46 ( 0.25- 0.83) Ezcluded/Trond : 01 ~ Non exposed 62 63 1.00 I 1.00 1.00 t 1.00 1.00 Exposed 79 98 0.82 ( 0.51- 1.33)' 0.84 ( 0.52- 1.36) f 0.81 ( 0.50- 1.33)~ 0.82 ( 0.51- 1.32) ~ 0.83 ( 0.51- 1.33) fxcludafd/Trond 1 2~ ~ ~ € I€ ~ GERMANY 3 Non exposod i 15 18 1.00 1.00 1.00 1.00 1.00 Exposed 15 33 0,55 l, 0.19- 1.59)l 0.54 ( 0.18. 1.57) 0.52 ( 0.17- 1.62) 0.69 ( 0.23- 2.08) 0.46 ( 0.15• 1.40) fxcl udld/Tlvnd ~ I ~ . d ITALY 1 Non exposed ~ 11 49 1,00 1.00 1.00 1.00 Exposed 27 162 0.62 ( 0.27- 1.40) 0.86 ( 0.34- 2.13) 0.85 ( 0.33- 2.16)1 0.64 ( 0.27- 1.50) ro 1.00 1 1.00 ( 1.00 3.53 ( 0.98-12.76)I 1.60 ( 0.36- 7.09)I 2.29 ( 0.76- 6.83) fxcludad/Trend ITALY 3 Non exposed Exposed 1 7 19 1.00 1.00 1.00 1.00 ; 1.00 t 9 31 0.60 ( 0.17- 2.12) 0.51 ( 0.13- 1.99) 0.40 { 0.08- 1.91) 0.51 ( 0.14- 1.89}1 0.60 ( 0.13- 2.71) fxcludid/Trandl 0 0 E PORTUGALI Non exposed ( 24! 15 Exposed 251 21 fzcludad/Trend PORTUGAL2 Non exposed Exposed 1.00 0.77 ( 0.31- 1.92) I E 0.79 ( 0.31- 2.02)I 1.00 17 1•00 1.00 00 16 12 0.95 ( 0.38• 2.35) 0.69 ( 0.25- 1.89) 0.89 ( 0.35- 2.26) f,rcludid/Trandl 0 SPAIN Non exposed Exposed f xcl uded/Trend SWEDEN Non exposed Exposed fxcluded/Trend UNITED KINGDOM Non axposad EXposed 29 41 45 67 1.00 i 1.00 0.94 ( 0.51- 1.75), 0.89 ( 0.47- 1.68) 1.00 0.89 ( 0.47- 1.68) [ 7 41 1.00 1.00 1.00 1.00 ~ 1.00 i 19 ~ 991 1.08 { 0.42- 2.81) 0.99 ( 0.38• 2.62) ~ 0.93 ( 0.35- 2.49) 0.93 ( 0.35- 2.47) 1.15 ( 0.44- 's.00) fxcluded/7rvndl 0~ 01 (1) Modo! Inchfde sex, csnter, sex•cantor and age (2) Model kulude sox, calter, st'x'csnter, age and proportion of residential type in the last 35 yrs (REUP) (3) Modst Include sox• oonter, sex'center, age, proportion of residential type in the last 35 yrs (REUP) and educational level (EDUC) (4J M@del rrtGhtdG sax, aan(vfF iRX'oentorE age and duradon of exposure to list A agents (OCLAY) (5) Mod®1 ii1clud4 s®x, center, sex'canter, age and frequency consumption of vegetables (VEGE) € 1.00 1.00 1.07)I 0.81 ( 0.63- 1.05)1 0.83 ( 0.64- 1.08) 0.82 ( 0.62- 1.08) OR(3) 95% CI j OR(4) 95% CI ( a`5R(5) 1.00 1.00 1.00 0.81 ( 0.63- 1.05)~ 0•79 ( 0.64- 0.98) 0.77 ( 0.61- 0.98) ~ 1.00 Risk estimates - Childhood_0-18 Years

OSUD Occasional smoking, Duration (years) (non overiapping) fTALY2 Tolat Ecposed Unexsed Excluded Min P10 ~ 01 Median ~ 03 i P90 ~ Max Mean ~ Std j Mon Csscf 3 0 3 0 Contrnls 97 18 78 1 0.50 0.50 1.00 2.00 10.00 25.00 1 31.00 6.22 8.68 AH 1001 18 81 1 0.50 0.50 1.00 2.00 10.00 25.00 31.00 6.22 8.68 Wom@n CasOs 16 4 12 0 1.00 1.00 2.00 4.00 16.00 27.00 27.00 9.00! 12.11 Controls 76 8 68, 0 0.50 0.50 0.75 4.00~ 7.50 10.00 10.00f 4.38/ 3.92 A11 92 12 80f 0 0.50 0.50 1.00 4.00f 7.50~ 10.00 27.00i 5.92i 7.41~ Cl36f 19 4 15 0 1.00 1.00 2.00 4.00 16.00! 27.00 27.00 9.00 12.11 Controls 173 26 146 1 0.50 0.50 1.00 2.50 ~ 10.00 f 10.00 31.00 I 5.65 7.50 AH 192 30 161 1 0.50 0.50 1.00 3.00 I 10.00 17.50 31.00 6.10 8.06 I7ALY 3 MOn € Cisas 1 0 1 0 ~ Controls 12 3 9 0 0.50 0.50 0.50 1.00 14.00 1 14.00 14.00 5.17 7.65 AH 13 3 10 0 0.50 0.50 0.50 1.00 14.00 14.00 14.00 5.17 7.65 VWmEn Cassf 15 1 14 0 1.00 ! 1.00! 1.00 1.00 1.00 1.00 1.00 1.00 . corxrotf 30 1 37 0 100' 1.001 1.00 1.00 1.00 1.00 1.00 1.00 AII 63 2 51 0 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 0.00 AII CasCs 96 1 15 0 1.00 1.00 1.00 1.00 1.00 '1.00 1.00 1.00 . Controls 50 4 46 0 0.50 0.50 0.75 1.00 7.50 14.00 14.00 4.13 a.59~ All 66 5 61 0 0.50 O.SD 1.00 1.00 1.00 1a.00 tA.00 3.50 5.67 PORTUGALI Men Cases 16 3 13 0 1.00 1.00 1.00 2.00 12.00 12.00 12.00 5.00 6.08 Controls 8 3 4 1 2.00 2.00 2.00. 4.00 12.00 12.00 12.00 6.00 5.29 All 24 6 ',7 1 1.00 1.00 2.001 3.00 12,00 ',2.00 12.001 5.50 5.13 Womin CaSms 33 4 29 0 1.00 1.00 1.50 6.00 12.50 15.00 15.00 7.00 6.68 Controls 31 1 28 2 4.00 4 00 4.00 4.00 4.00 4.00 4.00 4.00 . All 64 5 57 2 1.00~ ' ~ 1 00 2.00 4.001 10.00 15.00 15.00 6.40 5.94f AN ClSaf 49 7 42 0 1.00 1.00 1.00 2.00I 12.00 15.00 15.00 6.141 5.98 Controls 39 4 32 3 2.00 2.00 3.00 4.00! 8.00 12.00 12.001 5.50 4.43 PAA 88 ':1 74 3 1.00 1.00 2.00 4.00 12.00 12.00 15.00~ 5.91 5.24 POR7UGAL 2 Man Casat 10 9 0 0.50 0.50 0.50 2.00 4.00 41.00 41.00 9.72 15.91 Controls 17 6 10 1 1.00 1.00 2.00 2.50f 4.00 6.00 6.00 3.00 1.79 All 27 15 11 1 0.50 0.50 1.00 2.00f 4.001 34.00 41.00 7.03 12.54 'r'JOmsn 23 1 20 2 2.00 2.00 2.00 2.00 2.00 2.00 ~ 2.00 2.00 . I Controls 36 5 30 1 2.00 2.00 2.00 3.00 5.00 20.00 i 20.00 6.40 7.70 E All 59 6 50 3 2.00 2.00 2.00 2.50 5.00 20.00 20.00 5.67 7.12 yU Casas 33 10 21 2 0.50 0.50 0.50 2.00 4.00 37.50 41.00~ 8.95 15.19 Controls 53 11 40 2 1.00 2.00 2.00 3.00~ 5.00 6.00! 20.0 0 4.55 5.34 Aq 86 21 61 4 0.50 0.50 2.00 2.00 4.00 20.00f 41.0 01 6.64 11.10 SPAIN M.n CasCS 6 4 1 0.50 0.50 0.50 0.50 0.50 0.50 0.50 0.50 . Controls 13 1 61 6 0.50 0.50 0.50 0.50 0.50 0.50 0.50 0.50 A41 19 2 10 0.501 0.50 0.50 0.50 0.50 0.50 0.50 0.50 0.00 WomOn CasOf 65 4 531 8 0.50 0.50 12.75 28.50 36.00 40.00 40.00 24.38 17.05 Controls 146 16 117 13 0.50 0.50 1.00 7.00 31.50 35.001 45.00 14.19 15.89 All 211 20 170 21 0.50 0.50 1.00 9.00 33.50 37.50 45.00 16.23 16.21 AIl COSOf 71 a 57 9 0.50 0.50 0.50 25.00 32.00 40.00 40.00 19.60 18.23 1 Controls 159 17 123 19 0.50 0.501 1.00 5.00 28.00 35.00 45.00~ 13.38 15.741 iAll 230 22 180 28 0.50 0.50 1.00 7.00 32.00 35.00 45.00 14.80 16.10 SWEDEN Men CBSOf ^e3 16 7 0 1.00 1.00 1.00 1.50 93.001 31.00 44.00 8.50 12.94 Contr0ls 36 26! .0! 0 0.50 1.00I 1.001 2.00 5.00 40.00 45.00 7.88 13.27 All 1 59 42I 7I 0 0.50 1.001 1.00f 2.00 I ) 10.00 31.00 45.00 8.12 12.99 Woman Casas 47 33 14. 0 0.50 1.00 1.00 1.00 5.00 20.00 44.00 5.91 9.85 Controls 76 46 301 0 0.50 1.00 1.00 1.00~ 7.00 30.00 50.00 7.47 12.45 AH 123 79 441 0 0.50 1.00 1,00 1.00~ 5.00 26.00 50.00 6.82 11.39 All Casas 70 49 E1 0 0.50 1.00 1.00 1.00 5.00 21.00 44.00 6.76 10.89 Controls 112 72 40 0 0.50 1.00 1.00 1.25 6.00 30.00 50.00 7.62 12.66 AIl 182 121 61 01 0.50 1.00 1.00 1.00 5.00 26.00 50.00 7.27 11.93 Men Cssof J 0 0. 3 € I -- / onirols f ~ 6 17 0 01 ~ 7 Wofian Casas 23 0 0 23 € i € Controls 126 0 0 126 I ~ AA 149 0 0 149~ ~ All Cases ConUOls 26 140 0 0 0 0 26 140 ON ~ ~ AH 1661 o1 0 166 € ( rn Descriotive_statistics - Occasional smoking

Childhood 0-18 yrs, ever exposed to mother MEN ONLY L.v.lotl sur. Cases Controls OR1 95%Cf Non oxposCG Ess 201 1.00 Exposed 11 26 1.02 ( 0.39- 2.68) Frcluded/rrnndi WOMEN ONLY Non oxpototl Exposed 65 304 ~ OR(5) 95% CI .00 0.97 ( 0.32- 2.97) 187 295 1.00 1.00 1.00 1.00 1.00 26 54 0.84 l, 0.47- 1.48) 0.74 ( 0.39- 1.41) 0.97 ( 0.47- 2.02) 0.75 ( 0.42• 1.34) 0.71 ( 0.3738) fzcluded/Trvnd 296 662 ~ POPULATION BASED STUDIES Non exposed 152 326 1.00 1.00 1 .00 1.00 1.00 Exposed 17 45 0.77 ( 0.40• 1.49) 0.85 ( 0.43- 5.68) 1 1.03 ( 0.43- 2•49}~ 0.73 ( 0.37- 1.44) 0.80 ( 0.39- 1.65) Erclud>rd/Trend 209 579 HOSPITAL BASED STUDIES Non exposed Exposed 93 129 1.00 1.00 1.00 1.00 1.00 16 12 1.26 ( 0.53- 3.00) 0.81 ( 0-24- 2.74) 1.76 ( 0.38- 8.06) 1.17 ( 0.48- 2.82) 0.59 ( 0.18• 1.93) fxclud#d/Trend1 137 31Y WTTHOUT OCCASIONAL SMOKERS Non exposod Exposed 1 .~kc1 uded/Trend ~ AGE e53 YEARS Non exposod 67 14 1,00 Exposed 1 18 27 1,37 ( 0.61- 3.07 6xc1 udtd/Trend l 801 220 AGE b5•84 YEARS Non exposed ~ 76 76 1.00 Exposed 12 33 0.70 ( 0.30. 1.65) Erc1 uded/Trend 1?21 343 AGE 65+ YEARS Non oxposeo 109 206 1.00 Exposed , 20 0.74 ( 0.23• 2.33) Excluded/rrendl 1591 403 HISTOLOGICALLY CONFIRME D DIA GNO SIS Non exposeo 242 Exposed ~ 35 1 6xcluded/Tren.d~ 3501 966( € SQUAMOUS CELL CARCtNOMA Non expo=ed 52 496 1.00 ~ Exposed I ' r 80! 0.98 ( 0.39- 2.43)1 Excluded/rrend j 60l 966 SMALL CELL CARCINOMA Non exposea 28, 496 1.00 Exposed ~ 11 80 0.39 ( 0.04- 3.33)1 wxcluded/ Trendj 41 966 ADENOCARCINOMA 4961 1.00 80 1.02 ( 0.40. 1 6xcluded/rrei 701 966! >76% OF LIFESPAN IN RURAL AREA OR INTERMEDIATE CITIES Non exposed 113 188 1.00 Exposed ~ 6 33 0.49 ( 0.18• Excluded/Trendl 1371 363 >75% OF LIFESPAN IN URBAN AREA Non expoae0 70 215 1,00 Exposed ~ 12f I 35 0.85 ( 0.36• dxcludad/Trend~ 9621 4611 (1) Model Includa sox, center, sox'centar and age OR(2 95°4 Ci { OR(3) 95% CI ) OR(4 95% CI 1.00 1.00 1.00 1.13 ( 0.39- 3.30) 1.91 ( 0.32-11.36) 1.01 ( 0.37- 2.75) 1.00 1.00 1.00 1.00 0.96 ( 0.45- 2.06)~ 1.07 ( 0.46- 2.48) 0.91 ( 0.46. 1.80) 0.74 ( 0.33- 1.67)1 ! i 1.00 1.00 1.00 1.00 1.57 ( 0.60- 4.09) 1.97 ( 0.55- 7.03) 1.29 ( 0.54- 3.04) 1.48 ( 0.58- 3.77) 1_nn E i.nn t i nn 1.00 0.59 ( 0.22• 1.58)1 0.99 1 0.32- 3.04) 0.63 ( 0.26- 1.51) 0.47 ( 0.17- 1.27) 1.00 ~ 1.00 1.00 ----- P.00 0.61 ( 0.17- 2.18) 1.56 ( 0.39- 6.31)~ 0.73 ( 0.23- 2.33)1 0.77 ( 0.22- 2.68) ~ ~ 1.00 1.00 1.00 1.00 0.71 ( 0.23- 2.23) 1.12 ( 0.31- 4.04) 0.69 ( 0.24- 1.94) 0.55 (, 0.15- 2.01)' 1.00 1.00 1.00 1.00 0.42 ( 0.05- 3.68) 0.42 ( 0.05- 3.68)~ 0.48 (, 0,05- 4.32) 0.34 ( 0.04- 3.00) 1 1.00 2.61)~ 0.90 ( ! 0.32- 2.53) 1.00 1.00 1.11 ( 0.30- 4.14) 1.00 0.97 ( 0.38- 2.49) 1.00 1.08 0.37- 3.11) 1.00 1.00 ' 1.00 1.00 1.33) 0,49 ( 0.18. 1.33) 0.35 ( 0.10• 1.23), 0.41 ( 0.14• 1.18) 0.52 ( 0,19- 1.47) ~ 1.00 1.00 1.00 1.00 2.01) 0.85 ( 0.36- 2.01)~ 1.62 ( 0.55• 4.78) 0.76 ( 0.31• 1.85) 0.73 ( 0.27- 1.98) (2) Model Indude sex, csnter, sex'centar, age and proportion of residential type in the last 35 yrs (REUP) (3) Mode) Include sex, tanter, sex'oenter, age, proportion of residential type in the last 35 yrs (REUP) and educational level (EDUC) (4) Model Include sex, center, sex'center, age and duration of exposure to list A agents (OCLAY) (S) hfoda( hwuda aox, cen(ar, sax-ccn(cr, agc and frequency consumption of ve9etaotes (VEGE) ~ ---'-= - 38 Risk estimates - Childhood 0-18 years

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D_®SUD Occasional smoking, Duration (years) (non ovedapping) ALLCENTER; 1.aV11 ot a7cposuta Caaaz Contols OR(1 s5'f. Ct 9R(2) 95% CI ( OR 3 95% Ct 1 rJR(4 95% CI ( OR(5) 95% C( ~ NE., OSUD<5 569 1278 1.00 1.00 1.00 1.00 1.00 ,<0SU0<17 26 60 1.15 ( 0.69- i.91)~ 1.03 ( 0.59• 1.80) 1.40 ( 0.68- 2.86) 1.19 ( 0.71- 1.98) 1.03 ( 0.57- 1.88) 17<OSUD 17 34] 1.04 ( 0.56- 1.94)f 1.06 ( 0.57- 1.98) 0.91 ( 0•35- 2.39) 1.03 ( 0.55- 1.93)~ 0.95 ( 0.48- 1.88) Excluded/Trend 38l 1701 0.80 1 0.79 0.73 ~ 0.84 8 0.80 ALL CENTERS W€TH EDUCATIONAL LEVEL AND TY PE OF RES IDENCE NE,, OSUO<5 378 946 1.00 1 1.00 1.00 1.00 1.00 8<0SU0<s17 12~ 36 1.29 ( 0.63- 2.63)1 1•29 ( 0.63- 2.64) 1.40 ( 0•68• 2.86)~ 1.41 ( 0.68- 2.90) ~ 1.11 { 0.46- 2.66) 17<OSUD 6 19 0.86 ( 0.33- 2.27) 0.87 ( 0.33- 2.29) 0.91 ( 0,35- 2.39)i 0.87 ( 0.33- 2.29) 0.83 ( 0.28- 2.44) €Xcludad/Trendl 102) 337! 0.83 1 0.86 ~ € 0.96 0.83 0.83 ALL CENTERS WITH DIETARY DATA NE., OSUO<6 434 810 1.00 1.00 1.00 1.00 1.00 5<OSUD<17 98 37 1.02 ( 0.56- 1.86) 0.97 ( 0.52- 1.82) 1.19 ( 0.49- 2 84) 1.06 ( 0.58- 1.94) 1.03 ( 0.57- 1.88) 17<OSUO 14 26 0.95 ( 0.48- 1.88) 0.97 ( 0.49- 1.92) 0.87 ( 0.30- 2.56) 0.92 ( 0.46- 1.83) 0.95 ( 0.48- 1.88) Excluded/Trend 431 183 0.88 0.87 0.92 0.80 0-88 ~ FRANCE NE,r 0SUD<5 5<0SUD<.17 17<OSUD 07 131 1.00 1.00 1.00 1.00 1.00 7 15 0.90 ( 0.34- 2.36) 0.86 ( 0.30- 2.45) 1.43 ( 0.34- 6.08) 0.91 ( 0•35• 2.39) 0.89 ( 0.34- 2.33) 3 5 1.12 ( 0.26- 4.92) 1.23 ( 0.27- 5.67) 1.35 ( 0.20- 9.39) 1.11 ( 0.25- 4.88) ~ 1.12 ( 0.26- 4.91) :xcluded/Trandl 0 0 0.95 0.98 ~ 0.99 0.99 0.96 i GERMANY 1 _ NE,, OSUO<5 72 218 1.00 1.00 1.00 1.00 1-00 5<0SUD<17 3 7 1.43 ( 0.33• 6.19)] 1.19 ( 0.18• 7.71) 1.53 ( 0.23- 9.99) 1.64 ( 0.37• 7.38) 1.66 ( 0.37- 7.50) 17<0SU0 0 0.00 ( 0.00•99-99)/ 0.00 ( 0.00-99.99)( 0.00 ( 0.00-99.99) 0.00 ( 0.00-99.99) 0.00 ( 0.00-99.99) 5xcludod/Trend •I 3 0.75 0.70 ~ 0.79 0.78 0.82 ~ GERMANY2 ~ SUD<5 HE,, t7 141 157 1.00 1.00 1.00 1.00 1.00 6<0SU0<.17 1 4 0.36 ( 0.03- 3,76) 0.32 ( 0.03- 3.37) 0.35 ( 0.04- 3.51)1 0.36 ( 0.03- 3.75) 0.35 ( 0.03- 3.75) 17<OSUD 0 2 0.00 ( 0.00-99.99) 0.00 ( 0•00-99-99) 0.00 ( 0.00-99.99)1 0.00 ( 0.00-99.99) 0.00 ( 0.00•99.99) fxcludad/Trend l 01, 0 0.23 0.22 0.26 ~ 0.23 ~ 0.23 GERMANY3 NE•, u5U0<.6 t 30 51 1.00 1.00 ] 1.00 1.00 1.00 5<0SUD<r17 !, 1 0 99.99 ( 0.00-99.99) 99.99 ( 0.00-99.99)~99.99 (, 0.00-99.99) 99.99 ( 0.00-99.99) 99.99 ( 0.00-99.99) Exc1 uded/Trend l 1~ 0.99 0.99 ~ 0.99 0.99 ~ 0.99 ITALY I NE., 0SU0<5 36 206I 1.00 1.00 1.00 1.00 I 5<OSUD<17 4 9 f 3.69 ( 0.94•14.56) 2.91 ( 0.65-13.01) 2.87 ( 0.63-13.18) 4.97 ( 1.17-21,19) ~ 17<OSUD 0 Si 0.00 ( 0.00-99.99) 0.00 ( 0.00-99.99) t 0.00 ( 0.00-99.99) 0.00 ( 0.00-99.99) Excluded/Trand 0 11 0.64 0.67 ~ 0.67 E ' 0.64 (' ITALY 2 NE., 0S1.10<26 17 160 1.00 t.00 ] 1.00 1.00 + 5<OSUD<i7 1 10 1,04 ( 0.10-10.58) 1.60 ( 0.14•17.76) 1.93 { 0.14-26.53) 0.67 ( 0.05- 8.52) 17<OSUO ~ 1 2 1.20 ( 0.57-99.99) 6.14 ( 0.00-99.99) 5 7.85 ( 0.01-99.99) 14.28 ( 0.49•99.99)~ ] excludad/Trand 0~ 1 0 .14 j 0.58 0.39 ~ 0.18 ~ ITALY 3 NE., bsu0<5 5<OSUD<17 16 49 1.00 ! 1.00 1.00 1.00 1.00 0 1I E 0.00 ( 0.00•99.99)~ 2.78 ( 0.00-99.99) 99.99 ( 0.00-99.99) 0.00 ( 0.00-99.99) 0.00 ( 0. ~xcludad/Trand 0 II 01 ~ 0.99 ~ 1.00 E 1.00 0.99 ~ 0.99 PORTUGALI ~ NE., 05U0<5 46 35 1.00 1 00 ( s<osuD<17 3 1 2.16 j 0.21-22.54) ~ ~ 2.06 ( 0.20-21.77)~ ~ II 8'xc1 uded/Trand 0~ 3~ 0.52 ( F ~ ~ 0.50 ~ II ~ PORTUGAL2 NE., oSUO<3 29 48 1.00 1.00 1.00 6<OSUD<17 0 2 0.00 ( 0.00•99.99) 0.00 { 0.00•99.99)1 0.00 ( 0.00-99.99) E 17<OSUD E 2 1 ~ 4.29 ( 0.33-55.47) 1 4.41 ( 0.28-69.13) 4.46 ( 0.34-58.20) €xcluded/Trendl~ 2 2 1i 0.34 ] 0.27 ~ 0.33 ~ SPAlN NE., OS(1 O<5 5<OSUDe17 17<OSUD ( 59 131 1.00 1.00 1.00 1.00 1.00 ~ 0 3 0.00 ( 0.00-99.99) 0.00 ( 0.00•99.99) 0.00 ( 0.00-99.99) 0.00 ( 0.00•99,99) 0.00 ( 0.00-99.99) € 3 6 1.22 f, 0.29- 5.13) 1.17 1 ( 0.27- 5.03) 1.32 ( 0.30- 5.82)~ 1.19 ( 0-28- 5.02) 1.23 ( 0.29- 5.23) Excluded/Trandl 9 191 0.89 0.91 ~ 0.80 ~ 0.88 0.89 SWEDEN NE., 0SUD<5 56 92 1.00 1.00 i 7.00 c 1.00 5<0su0<17 6 8 1.32 ( 0.42- 4.09) 1.26 ( 0.40• 3.93) 1 1.30 ( 0.41- 4.08)~ 1.35 ( 0.43- 4.23) 17<0SU0 12 1.11 ( 0.42- 2.93) 1.14 ( 0.43- 3.01) 1.02 ( 0.37- 2.79) 1.10 ( 0.41- 2.95) Excludad/Trend UNITED K)NGDCM 01 0.79 0.76 t 0.92 ~ 0.80 (1) Medel Indude sex, center, sex'ccnter and age (2) Mode) inciude a0X, eenter, sex'center, age and proport)on of residential type in the last 35 yrs (REUP) (3) Model indude sox, center, sex'center, age, proportion of residential type in the last 35 yrs (REUP) and educational level (EDUC) (4) htoac( induae aex, estlear, SCx-c6n(G(, c7g0 and duraqon or exposurg to list A a9ents (OCLAY) (5) Model include aex, center, sex•center, age and frequency consumption of vegetables (VEGE) Risk estimates - accasional smoking 00-99.99)

0SCU Occasional smoking, Cumulative exposure (packsilifetime) MEN CNLY Total ExoosCd Urexposad Exduded Min ~ P10 01 Median 1 03 ~ P90 Max ( Mean Std ! Ma1 Caaos 964 40 110 d 0.05 0.08 0.25 2.40 5.30 8.40 18.00 3.74 4.40 Controls 566 145 397 24 1 0.05 0.13 0.50 2.05 6.90 13.00 ~ 20.00 4.55 5.40 AN 737 1$5 5071 45 f 0.05 0.10 0.50 2.40 6.50 13.00 20.00 4.38 5.20 Womon Casaa 0 0 0 0 € gg Controls 0 0 0 0 ' All 0 0 0 0 AN C8s8s 157 40 110 7 0.05 0,08 0.25 2.40+ 5.30 I 8.40 18.00I 3.74 4.40! ~ls ~ 2.05 s ~ 13 01 ~ 1 At 737 185 507 45 0.05 0.10 0.50 z.40 6.50+ 13.00 20.00 4.38 5.20 MOR GOSOS 0 0 0 0 Carttrois 0 0 0 0 ~ i Al€ 0 0 0 0 € € ! V40ntan f CasOS 527 93 419 15 0.03 0.05 0.15 0.75 3.00 9.00 18.25 2.90 4.77 [ Controls 950 179 747 24 0.03 0.05 0.15 1.00~ 4.00 40 ~ i1. 99.20 3.11 4.63~ All 1626 272 1166 198 0.03 0.05 0.1 5 5 .60 .20 1.00 3 11 19.20 3.04 4.671 AH Cases `S50 93 419 38 0.03 0.05 0.15 0.75 3.00 9.00 18.25 2.90 4.771 Controls 1076 179 747 150 0.03 0.05 0.15 1.00 4.00 11.40 19.20~ 3.11 ~ 4.631 All 1626 272 1166 188 0.03 0.05 0.151 1.00 3.601 11.20 19.20( 3.04 4.67t POPULA11ON 9ASE0 TUDIE Men Cases Controls All 91 444 535 23 115 138 58 314 382 0 15 15 0.05 0.05 0.05 0.05 0.15 0.10 0.50 0.10 0.40 1.00 1.50 1.40 4.00 5.30 5.20 5.40 13.00 "2.00 16.30 20.00 20.00 2.32 4.04 3.76 3.68 5.17. 4.98' WomOn Casss 287 60 226 1 0.03 0.05 0.10 0.50 2.00 7.40 18.25 2.17 3.96 Controls 508 99 404 3 0.03 0.05 0.08 0.50 3.60 12.00 18.25 2.96 4.791 Att 793 159 630 4 0.03 0.05 0.10 0.50 2.60 10.40 18.25 2.66 4.50' Aft Cases 378 83 294 1 0.03 0.05 0.10 0.50 2.60 6.50 18.251 2.21 3.86 Controls 950 214 718 18 0.03 0.051 0.25 <.00 5.00 12.00 20.00, t 3.54 5.02 All 1328 297 1012 19 0.03 0.0s 0.15 1.00 4.00 10.50 20.001 3.17 4.75 HOSPITAL BASED STUDIES t.tan CasCS 47 16 27 4 0.10 2.05 2.45 4.48 7.80 13.00 18.00 5.98 4.63 j Controls 73 28 36 9 0.05 0.20 1.00 3.75 12.051 15.00 17.55 6.11 5.68 All ; 120 44 63 13 0.05 0.25 2.22 3.83 9.40 13.00 18.00 6.06 5.27 roman Cases 199 33 152 14 0.05 0.10 0.401 1.50 5.20 15.50 18.00 4.23 5.80 Controls 379 80 278 21 0.03 0.10 0.48~ 1.20 5.10 10.60 19.20 3.31I 4.45 All 678 113 430 35 0.03 0.10 0.45 1.20 5.20 12.00 19.20 3.58f 4.88 .N Cases 246 49 179 18 0,05 0.10 0.50 2.50 7.80 15.50 18.00 4.80 5.46 Controls 452 108 314 30 0.03 0.10 0.50 2.00 6.00 13.00 19.20 4.03 4.93 All 698 157 493 48 0.03 0.10 0.50 2.40 7.20 13.00 19.20 4.27 5.10~ ~Man Cases 112 0 110€ 2 - ~ ~~~ ! Controls 406 0~ 397 9 '~(D3J~~ ~ ~ ~AN 518 01 507 11 ~ Vvoman Cases 430 0 41s 1t ` ~ ~ -- -- "~ Controls 810 63 0 747 All 1240 0 1166 74 ~ AA €Casas 642 0 52s 13 ConUols 1216 0 1144 72 ~ ~ i A11 1758 0 1673 851 ! Man Cases 56 16 39 1 0.15 0.50 1.98 5,10 7.50 9.00 18.00 5.27 4.39 Controla 170 51 116 3 0.05 0.25 0.751 1.80 7.80 15.60 20.00 4.93 5.89 All 229 67 155 7 0.05 0.25 1.001 2.50 7.80 15.60 20.00 5.01 5.54 Woman Casas 138 28 106 4 0.05t 0.05 0.13 0.801 1.75 15.50 18.25 2.82 5.37 Controls 254 72 174 8 0.031 ! 0.05 0.25 0.95 f 3.80 11.401 15.60 3.02 4.33 All 392 100 280 12 ' 0.03 0.05 I 0.15 0.95 3.05 11.70 18.25 2.97 4.62 Atl Casas 195 44 145 6 0,05 0.10 0.18 1.381 5.30 9.00 18.25 3.71 S.13 Controls 426 123 290 13 0.03 0.05 0.30 1.20 5.20 13.00 20.00 3.81 5.1C All 621 167 435 19 0,03 0.08 0.30 1.20 5.20 13.00 20.00 3.79 5.05 AGE SS.84 YEARS MAt1 CaSas 52 13 38 1 0.05 0.05 0.25 2.051 2.60 5.20 16.30 ~ 2.90 4.32 Controls 216 47 163+ 6 0.05 0.05 0.38 2.50 5.20 12.00 20.00 3.961 4,74 All 268 60 201f 0.05 0.05 0.31 2.45 5.00 ':1.00~ 20.00 3.73 4.64 WCmOn Cases 166 34 127 5 0.03 0.05 0.13 0.50 3.00 7.80 18.00 2.531 . 4.5E Controls 304 56 243 5 0.03 0.05 0.10 0.50 2.70 9.00 18.25 22.631 4,35 AN $35 90 370 75 0.03 0.05 0.10 0.503.00 8.40 18.25 2.59 4,4- AA Cases 228 47 166 16 0.03 0.05 0.13 0.50 3.00 7.80 16.00 2.63 4.4; Controls 575 103 406 66 0.03I 0.05 0.20 1.00 5.00~ 10.00 20.00~ 3.24 4.5E All 803 _150 571 82 0.03 0.05 0.151 1.00 3.90 9.30 20.00 3.05 4.5~ AGE 65+ YEARS Mon Casos ! 46 11 33 2 0.05 0.05 0.10 0.25 4.00 7.80 13.00 2.50 4.2- CONrols ~ 180 47 118 15 0.05 0.10 0.50 1,85 9.00 13.00 19.80 4.74 5.5i All 240 58 151 31 0.05 0.10 0.30 1.40~ 6.90 13.00 19.80 4.31 5.3= Woman Cisos 223 31 186 6 0.05 0.05 0.50 1.00 5.20 12.50 15.60 3.39 4.5' Controls 392 51 330 11 0.05 0.05 0.15 1.20 S.aO 12.00 19.201 3.77 5.25 All 699 82 516 101 0.05 0.05 0.20 1.201 5.20 12.60 19.20~ 3.62 4.9E Afl Casas 284 42 219 23 0.05 0.05 0.15 1.00 5.00 12.60 15.60 3.161 4.4i Controls 655 98 448 109 0.051 0.05 0.30 1.40 6.75 13.00 19.80 4.23( 5.4t All 939 140 667 132 0.05 0.05 0.25 1.20 5.70 13.00 19.80 3.91i 5.1: Descriptive statistics - Occasionai smoking

2.3.3 Spouse Risk estimates

C _S~SU D Occasional smoking, Duration (years) (non overlapping) av.~CS_t~as Leve1 of ex osure Non exposed 0<OSUD<5 g<OSUD<H 7 17<OSUD CaSes Controls OR11) 95% Cl OR(2 95X CI OR(3 95% CI j OR 4 95% CI OR(5) 95% CI I, ! 473 1032 1.00 1.00 1.00 1.00 1.00 96 246 0.89 ( 0.66- 1.22) 0.98 { 0.71- 1.37) 0.94 ( 0.62• 1.44) 0.92 ( 0.67- 1.26) 0.78 ( 0.54- 1.11) 26 60 1.11 ( 0.66- 1.86) 1.03 ( 0.58- 1.81) 1.38 ( 0.67• 2.84) 1.16 ( 0.69• 1.95) 0.94 ( 0.51• 1.74) 17 34 1.00 ( 0.53- 1.88) 1 1.D6 ( 0.56- 1.99) 0.90 ( 0.34- 2.37) 1.00 ( 0.53- 1.89) 0.86 ( 0.43- 1.73) Excludtd/Trend 28 170 0.84 0.83 0.75 O.B9 0.84 ALL CENTERS WITH EDUCATIONAL LEVEL AND TYPE OF RESIDENCE Non expos.d 0<OSUD<5 5<0SUD<17 17<0SUD Excluded/Trand~ 102 ALL CENTERS WITH DIETARY DATA Non exposed 0<OSUD<5 g<0S(10<17 17<OSUD €xcludad/Trend FRANCE Non .xpozatl 0<o$UDtrS 5<0$UD<.17 17<OSUD 543 167 37i 26i( 183 1.00 ( 1.00 1.00 t.00 1.00 0.91 ( 0.59• 1.38) 0.91 ( 0.60- 1.39) 0.94 ( 0.62- 1.44) 0.92 ( 0.60- 1.42) 0.76 ( 0.47- 1.24) 1.26 ( 0.62• 2.59) 1.27 ( 0.62- 2.60) 1.38 { 0.67- 2.84) 1.38 ( 0.67- 2.87) 1.04 ( 0.43- 2.52) 0.85 ( 0.32- 2.23) 0.86 ( 0.33- 2.26) 0.90 ( 0.34- 2.37) 0.86 ( 0.33- 2.26) 0.79 ( 0.27- 2.33)i 0. 73 0.77 0.87 0.73 0.73 Et 1.00 1.00 1.00 1.00 1.00 0.78 ( 0.55- 1.12) 0.87 ( 0.60- 1.26) 0.78 ( 0.48- 1.27) 0.78 ,( 0.54- 1.12) 0.78 ( 0.54- 1.11) 0.94 ( 0.51• 1.73) 0.92 ( 0.48- 1.75) 1.12 ( 0.46- 2.70) 0.97 ( 0.52- 1.81) 0.94 ( 0.51• 1.74) 0.86 ( 0.43• 1.73) 0.92 ( 0.46- 1.85) 0.83 ( 0.28- 2.46) 0.83 ( 0.41- 1.69) 0.86 ( 0.43- 1.73) 0.81 0.80 0.86 { 0.73 0.80 44 73 1.00 1.00 1.00 1.00 1.00 23 58 0.63 ( 0.34- 1.18) 0.83 ( 0.41• 1.67) 1.14 ( 0.47- 2.77) 0.62 ( 0.33- 1.18) 0.6a ( 0.34- 1.20) 7 15 0.75 ( 0.28- 2.03) 0.80 ( 0.27- 2.35) 1.55 j 0.33- 7.23) 0.75 ( 0.28• 2.04) 0.75 ( 0.28- 2.01) 3 5 0.92 ( 0.20• 4.14) 1.12 ( 0.24- 5.33)~ 1.46 ( 0.20-10.75) 0.90 ( 0.20- 4.08) 0.92 ( 0.21- 4.15) Excluded/Tr.nd 0 0 0.96 ( 0.90 0.92 0.92 1 0.96 ~ GERMANYI Non exposed 0<0SU0<5 5<0SUD<17 17<OSUO 63 181 1.00 1.00 1.00 1.00 1.00 9 37 0,85 ( 0.37• 1.95) 0.95 ( 0.40. 2.26) 0.86 ( 0.35- 2.11) 0.77 ( 0.32- 1.84) 0.88 ( 0.37• 2.05) 3 7 1.40 ( 0,32• 6.07) 1.18 ( 0.18- e'.68) 1.49 ( 0.23- 9.81) 1.59 { 0.35- 7.15) 1.64 ( 0.36• 7.40) 0 1 0.00 ( o.00•s9.99) 0.00 ( 0.00•99.99) 0.00 ( 0.00-99.99)i 0.00 ( 0.00•99.99) 0.00 ( 0.00-99.99) Exclud~d/Trond 1 a 0.71 0.65 0.72 i 0.74 0.76 GERMANY 2 Non exposed 137 1471 0<0SUD<.5 4 10 5<OSUD<17 1 4 17<OSUD 0 2 c'xc1 uded/Trend 0 0 GERMANY 3 Non exposed 0<0SU0<r5 5<0SUD<17 excluded/Trendl 01 ITALY I NOn eXpOSed 28 0<OSUD<5 8 3<0SUD<17 4 17<0SU0 0 &cludtd/Trendl 0 ITALY 2 Non exposed 15 0<05U0<5 2 5<0SU0<17 i 17<0SU0 r<xcluded/Trend ITALY 3 1.00 0.45 !, 0.13• 1.49) 0.35 ( 0.03- 3.63) 0.00 ( 0.00•99.99) 0.21 49 1.00 0.00 2 i ( 0.00•99.99) 0199.99 ( 0.00-99.99) ' 0.40 155 1.00 51 1,16 ( 0.47- 2.86) 9+ 3.81 ( 0.95-15.27) 5I 0.00 ( 0.00•99.99) ' 0.65 1461 1.00 14 1.99 ( 0.35-11.31) 10 1.09 ( 0.11•11.18) 2116.58 ( 0.53•99.99) ,* 1 0.13 1 .00 1.15 ( 3.00 ( 0.00 ( 0.68 0.44- 2.99) 0.66-13.65) 0.00-99.99) 1.00 1.35 ( 3.07 f, 0.00 ( 0.68 0.51- 3.62) 0.65-14.44) 0.00•99.99) 1.00 1.35 ( 5.33 ( 0.00 ( 0.65 0.54- 3.38) 1.22-23.23) 0.00-99.99) 1.00 1.00 E 1.00 1.48 ( 0.21•10.57) 3.68 ( 0.39•34.66) 2.15 ( 0.37-12.43) 1.63 ( 0.15•18.24) 2.18 ( 0.16•30.30) 0.69 ( 0.05- 8.98) 6.86 ( 0.00-99.99) 11.11 ( 0.01•99.99) 15.59 ( 0.51-99.99) 0.56 t 0.39 ) 0.17 1.00 0.34 ( 0.09- 1.30) 0.35 ( 0.03- 3.62) 0.00 ( 0.00-99.99) 0.21 F i Non exposeo 15 46 1.00 = i.oo 1.00 1.00 1.00 0<OSUD<5 ', 3 1.83 ( 0.14•24.62) 1.50 ( 0.05-42.32) 0.90 ( 0.03•27.22) 2.20 ( 0.15-33.19) 2.26 ( 0.14•37.10) 5<OSUD<17 0 11 0.00 ( 0.00•99.99) 2.83 j 0.00-99.99) 99.99 ( 0.00-99.99) 0.00 j 0.00-99.99) 0.00 ( 0.00-99.99) fxcluded/Trend 0 01 0.91 0.93 { 0.99 0.96 0.91 PORTUGALI Non exposoc 42 0<0SU0<5 ~ 4 6<0SUD<17 tt 3 .Excluded/Trendi 0 PORTUGAL2 Non Rxposed 21 32 3 3 1.00 ; 0.71 ( 0.14- 3.76) 2.08 ( 0.20•21.93) 0. 56 1 00 1.18 ( 0.19. 7.56) 2.09 ( 0.20•22.12) 0.54 40 1.00 1.00 1.00 0<OSUD<r5 8 8 2.62 ( 0.66-10.32) 2.40 ( 0.45-12.44) 2.37 ( 0.59- 9.52) ~ 5<OSUO<17 0 2 0.00 ( 0.00•99.99) 0.00 ( 0.00-99.99) 0.00 ( 0.00-99.99) ~ 17<OSUO 2 1 6.34 ( 0.45-89.99) 5.70 ( 0.35-93.61) 6.30 ( 0.44-90.01) Excluded/7rand l 2 21 0.30 ~ 0.25 ~ 0.29 ~ 57 123 1.00 1.00 1.00 1.00 1.00 0<OSUD<r5 2 8 0.52 ( 0.10- 2.77) 0.62 ( 0.11- 3.39) 0.55 ( 0.09- 3.30) 0.63 ( 0.11- 3.44) 044 ( . 0.08- 2.39) 5<OSUO<r17 ~ 0 ~ 3 I 0.00 ( 0.00•99.99) 0.00 ( 0.00-99.99) 0.00 ( 0.00-99.99) 0.00 { 0,00-99.99) 0 .00 ( 0.00•99.99) 3 ' i.i9 ( 0.28• 4.99) 1.14 ( 0.27- 4.91) 1.28 1 0.29- 5.65) 1.17 ( 0.28- 4.92) 1.18 ( 0.28- 5.05) f.YCluded/Trandl 9~ 191 0.91 0.93 0.83 ~ 0.90 0.92 ~ SWEDEN Non axposad 21 ao 1.00 1.00 1.00 ~ 1.00 Of0$UD<5 351 52 1.49 ( 0.73- 3.05) 1.54 ( 0.75- 3.16) 1.41 ( 0.69- 2.90) 1.45 ( 0.71- 2.99) 5<OSUD<il 6i 8 1.68 ( 0.50• 5.69) 1.63 ( 0.48- 5.54) 1.60 ( 0.47- 5.48) 1.69 ( 0.49- 5.77) 17<OSUO ~ 8 f 12 1.42 ( 0.49- 4.13) 1.48 ( 0.51- 4.34) E 1.26 ( 0.42- 3.79) 1.38 ( ~ 0.47- 4.09) Exc1 uded/Trond 0 I {Ill 0 0.75 0.72 €t 0.88 0.76 UNITED KINGDOM Exclutled/Trendl 26 140 i (1) Model indude sex. center. sex•center and age (2) Model include sex. center, sex'ccnter, age and proportion of residential type in the last 35 yrs (REUP) (3) Model include sexx center, sex'center, age, proportion of residenUat type in the last 35 yrs (REUP) and eduqtional level (EDUC) (4) Model include sex, center, sex•center, age ano duratiOn of exposure to list A agents (OCIAY) (5) Model )ndude sex, center, sex'center, age and frequency consumpoon of vegetabtes (vEGE) Risk estimates - Occasional smoking

OSUD Occasional smoking, Duration (years) (non overiapping) HISTOLOGICALLY CONFIRMED DIAGNOSIS Tola1 Exposed Unexposed Man Cassz 149 39 109 Controts 566 556 397 An 732 195 506 Womon Casos 513 97 408 Controls 950 186 747 All 1607 283 1153 Excluded Min P10 01 1 Median 1 03 i P90 Max ~ Mean Std 1 0,50 1.00 1.00 2,00 10,001 31.00 44.00 7.37 11,39 13 0.50 0.50 1.00 2.00 4.50 12.00 46.00 4.88 'a.50 31 0,50 0.50 1.00 2.00 5.00 12.00 46,00 5.37 9.17 10 0,50 0.50 1,00 2.00 5.00 20.00 44.00 6.23 9.68 17 0.50 0.50 1.00 2.00 5.00 20.00 50.00 6.18 9.83 171 0.50 0.50 1.00 2.00 5.00 20.00 50.00 6.20 9.76 AA Cassz 683 136 515 32 0.501 1.00 1.00 2.001 6.00 20.00 §4.00 6,56 1 10.17 Controls 1656 342 144 170 0.50! 0.50 1.00 2.00 4i 5.00 16.00 ~ 50.00 5.58 ! I 9.2E Afl 2339 478 1659 202 0.50 0.50 1.00 1 2.00 5.00 18.00 50,001 ' 5.86 9.52 80UA14OUS CELL CARCINOMA Mon Cases 28 8 20 0 1.00 1.00' 1.00 7,50 13.50 41.00 41.00 10,75 13.38 Controls 568 156 397 13 0.50 1 0.50~ 1.00 ~ 2.00 4.50 12.00 46.00 4.88 8,50 °All 608 164 417 27 0.50 0.50 1.00 2.00 5.00 12.00 46.00 5.16 8.83 Women Cases 91 /7 72 2 0.50 1.00 1.00 2.00 4.00 15.001 25.00 4.21 6.37 Controls 950 186 747 17( 0.50 0.50 1.00 2.00 5.00 20.00 50.00 6.18 9,83 All !173 203 819 151 0.50 0.50 1.00 2.00 5.00 20.00 s0.00 6.01 9.59 AlI CaSOs 125 25 92 8 0.50 1.00 1.00 2.00 5,00 15.00) 41.00 6.30 9.43 ~ Controls 1656 342 1144 170 0.50 0.50 1.00 2.00 5.00 16.00 f 50.00 5.58 9.25 All l761 a67 1236 178 0.50 0.50 1.00 2.00 5.001 1l 16.00 50.00 5.63 9.2E SMALL CELL CARCINOMA Mon Cases 13 Controls 666 All 594 ' 12 0 3.00 3.00 1 3.00 3.00 3.00! 3.00! 3.00 3.00 156 397 13 0.50 0,50 1.00 2.00 4,50! 12.00 I 46.00 4.88 8.5C 167 409 28 0.50 0.50 1.00 2.00 4.00i 12.00 46.00, 4.861 8.47 Wommn Cascz 62 8 52 2 1.00 1.00 1 1.00 2.50 6.00 10.00 10.00 3.75 3.3: Controls 950 186 747 17 0.50 0.50 1.00 2.00 5.00 20.00 50.00 6.18 9.8: All 1143 194 799 150 0.50 0.50 1.00 2.00 5.00 20.00 50.00 6.08 9.65 All CisaS 31 9 64 8 1.00 1.00 1.00 3.00 5.00 10.00 10.00 3.67 3.12 Controls 1656 342 1144 170 0,50 0.50 1.00, 2.00 5.00 16.00 50.00 5.58 9.2E 1737 351 1208 178 0.50 0.50 1.001 2.00 5.00 15.00 50.00 5.54 9.1E ADENOCARCINOMA Men Casas 79 566 Controls All 680 23 55 1 0.50 1.00 1.00 2.00 10.00 31.00 44,00 8.13 12.2E 156 397 13 0.50 0.50 1.00 2.00i' 4.50 12.00 46.00 - 4.88 S.SC 179 452 29 0.50 0.50 ':.00 2.001 5.00 12.00 46.00 5.29 9.1C Women Cases 277 55 218 4 0.50 0.50 1.00 1.00 5.00 15.00 32.00 5.21 7.8E Controls 950 186 747 17 0.50 0.50 1.00 2.00 5.00 20.00Jf 50.00 6.18 9.85 All 1367 241 965 151 0.50 0,50 ':.00 1.00 5.00 20.00i 50.00 5.96 9.41 ~tl CosaS 361 78 273 10 0.50 0,50 1.00 1.50 5.00 20.00 44.00 '.07 9.4: Controls 1656 342 9144~ 170 0.50 0.50 1.00 2.00 5.00 16.00 50.00 5.58 9.25 AII 2017 420 ?417 180 0,50 0.50 7,00 2.00 5.00 17.50 50.00 5.68 9.27 OTHER -Men 62541 29 22 0 1.00 1.00 1.00 1.00 3.00 3.50 3.50 1.64 1.19 Controls 566 156 397 13 0.50 0.50 1,00 2.00 4.50 12.00 46.00 4.88 8.5C A11 610 163 419 28 0,50 0.50 1.00 2.00 I 4.00 11.001 46.00 4.74 8.3~ CasoS 83 17 64 2 0.50 1.00 1,00 3.00 27.00 40.00 44.00 12.74 15.8: Controls 950 186 747 17 0.50 0.50 1.00 2.00 5.00 20.00 50.00 6.18 9.8: All !96z 203 s11 148 0.50 0.50 00 2.00 6.00 24.00 50.00 i 6.73 10.5E AA 9 116 24 86 6 0.50 1.00 1,00 2.00 14.00 40.00 44.00 9.50 14.15 1656 342 1144 170 0.50 0.50 1.00, 2.00 5.00 16.00 50.00 5.58 9.2 1772 366 1230 ".76 0.50 0.50 t.00 2.00 5.00 19.00 50.00 5.84 9.6E >75% OF LIFESPANIN Man Casos 73 20 53 0 0.50 0.75 9.00 2.50 7.50 32.50 47.00 7.90 12.2~ CGnlf013 212 52 1 157 3 0,50 0.50 1.001 2,00~ 5.00 10.0C 40.00 4.46 7.2i All 301 72 210 !9 0,50 0.50 1.00 2.00 5.00 12.00i 41.00 5.42 8.9' F Woman Cas a S 220 28 189 3 0.50 0.50 1.00 1.00 4.50 18.00 40.00 5.45 9.6- Controls 361 75 285 1 0,50 1.00 1,00 1.00 5.00 20.00 50.00 6.08 10.0, A1M 699 103 474 122 0.501 1.00 1.00 i.00 5,00 19.00 50.00 5.91 9.9{ A)I Cmsos 313 6 242 23 0,50 0.50 9.00 1.00 5.00 31.00 41.00 6.47 10.7t 687 127 442 118 0,50 0.50 1.00 2.00 5.00 16.00 50.00 5.42 9.0~ ~ All 1000 `.75 684 141 0.50 0.50 1.00 1.00 5.00 18.00 50 .00 5.71 9.5 >75% OF LIFE5PAN IN URBAN AREA Man Cases 48 Controls 257 17 30 1 0.50 0.50 1.00 1.00 10.001 20.00 44.00 6.91 11.1 76 174 7 0.50 0.50 i.00 2,001 4.00 10.00 46.00 4.39 8.4 All 305 93 204 8 0.50 0.50 1.00 2,00 4.00 10.00 46.00 4.85 8.9 tiYcxllon Cases 193 47 141 5 0.50 0.50 1,00 2.00 5.00 20,00 44,00 5.93 10.0 Contro:s 435 85 339 11 0.50 0.50 1,00 2.00 10,00 26.00 45.00 7.41 10.5 All 650 132 480 38 0,50 0.50 1.00 2.001 6.50 23.00 45.00 €.88 10.3 All Ca:aS 244 64 171 9 0,50 0,50 1.00 2.00 5.00 20.00 44.00 6.19 10.3 Controls 711 161 513 37 0.50 0.50 1 1.00 2.00 5.00 20.00 46.00 5.99 9.7 A~ 955 225 684 46 0.50 0.50 1.00 2.00 5,00 20.00 46.00 6.04 9.8 RURAL AREA OR INTERMEDIATE CI71ES Descriptive statistics - Occasional smoking

Table 2.1.6 Distribution of subjects by age, center and gender Men Women ~ Both genders Cases ? Controls Cases Controls Cases Controls N ( °'o N .°-o E N % N io N % N ( °o <45 years 6 42.9 5 21.7 5 7.9 9 ! 7.0 11 14.3 14 9.3 45-54 1 7.1 4 17.4 18 28.6 33 1 25.8 ( 19 24.7 37 24.5 France 55-84 3 ~ 21:4 7 i 30:40 16 25.4 34 26.6 18 ~ 23.4 37 24.5 71-75 3 21.4 4 17.4 7 11.1 16 12.5 10 13.0 20 13.2 <45 years 4 22.2 8 6.2 1 1.7 ~ 5 5.0 5 6.6 1 3 5.7, 45-54 4 22.2 31 24.0 7 12.1 1 11 11.0 11 14.5 42 18.31 Germany 1 55-64 5 27.8 57 1 44.2 ~ 12 20.7 ~ 33 1 33.0 ~ 17 22.4 90 39.3 65-70 4 22.2 19 1 14.7 19 32.8 1 31 31.0 I 23 30.3 ~ 50 21.8 71-75 1 5.6 1 14 1 10.9 19 1 32.8 20 ' 20.0 ( 20 26.3 34 1 14.8 <45 years 4 13.8 5 7.7 3 2.7 2 2.0 7 4.9 7 4.3 45-54 7 24.1 14 21.5 1 21 18.6 19 19.4 28 19.7 33 20.2 Germany 2 55-64 14 48.3 38 58.5t 45 39.8 37 1 37.8 59 41.5 -'5 46.0 85-70 2 ~ 6.9 4 6.2 ~ 27 23.9 22 ~ 22.4 I 29 20.4 ~ 26 16.0 71-75 2 ! 6.9 1 4 6.2~ 17 15.0 18 18.4 19 13.4 22 13.5 <45 vears I y ~ . 1 2.6 1 1.9 45•54 3 30.0 j 6 42.9 4 ~ 19.0 3 7.9 7 22.6 9 17.3 Germany 3 55-64 5 50.0 1 3 21.41 7 33.3 15 39.5 12 38.7 18 34.6 ~ 65-70 2 20.0 1 1 7.1 4~ 19.0 11 28.9 6 19.4 12 23.1 _ f 71•76 .; 4~ ~ 28.6 6I 28.6 8 21.1 6 19.4 12 23.1 ~ <45years 6j 5.8 7 5.9 f 13 5.9 45-54 2 ~ 25.0 ~ 19 18.4 9 28.1 23 19.5 11 27.5 421 19.0 Italy 1 55-64 31 37.51 35~ 34.01 10 31.31 28 23.7 I 13 32.5 63 28.5 65-70 21 25.0 30 29.11 9 28•1 37 31.4 , 11 27.5 67 30.3 f 71•75 1 12.5 131 12.6 4 12.5 23 19.5 5 12.5 36 16.3 ~ <46years 1 33.3 1 1.01 . 5 6.6 1 5.3 6 3.5 45-54 ; i 22 22.7~ 1 ~ 6.3 101 13.21 1 5.3 32 18.5 Italy 2 55-64 .i , ' 37 38.1 ~ 9 56.3~ 32 I 42.1 9 47.4 69 39.9 1 65-70 1 33.3 21 21.6 3~ 18.8I 16 21.1 4 21.1 37 21.4 1 71-75 1 33.3 16 16.5 3I 18.8 13j 17.1 4 21.1 29 16.8 <45 years 1 1 100.01 4 33.3 . . 3 7.9 1 6.3 7 14.0 ~ 45-54 ~ 1 2 16.7 I 1 6.7 6 15.8 1 ) 6.3 8 16.0 Italy 3 ( 55-64 i 3, . 25.0 3 20.0 11 28.9 3 18.8 14 28.0 ~ 65-70 31 25.0f 7 46.7 11 28.9 7 43.8 14 28.0 i 71-75 ; I 4 26.7 7 18.4 4 25.0 7 14.0 g <45vears 1 6.3 F .' 5~ 15.2 41 12.9 6 ^:2.2 4 10.3 45-54 4~ 25.01 51 62.5 I 71 21.2 ~ 8 25.8 11 I 22.4 13 33.3 Portugal 1 55-64 6 . 37.5~ 3 37.51 14 42.4 10 32.3 20 40.8 13 33.3 1 65•70 2 12.5, . ~ 4 12.1 7 22.6 6 12.2 7 17.9 ; 71-75 3~ 18.8I 3 9.1 2 6.5 6 12.21 2 5.1 <ASyears 11 10.0~ 4~ 23.5 4 17.4 51 13.9 5 15.2 9 17.0 45-54 31 30.01 5 29.4 ~ 3 13.0 ~ 4I 11.1 6 18.2 9 17.0 Portugal 2 5564 51 50.01 7~ 41.2~ 6` 26.1 13( 36.1 11 33.3 20 37.7 ~ 65-70 1 I 10.01 1 5.91 3 I 13.0 ~ 9 I 25.0 4 12.1 10 18.9 71-75 ,~ 71 30.4 5' 13.9 21.2 5 9.4 <45 years 1 I 16.7. 1 7.7 6 9.2 14 9.6 7 9.9 15 9.4 45-54 . 1 7.7 8 12.3 12 8.2 8 11.3 13 8.2 Spain j 55-64 1I 16.7 41 30.81 21 32.3 54 37.0 22 31.0 58 36.5 ~ 65-70 2; 33.3 61 46.2 13 20.0 37 25.3 15~ 21.1 43 27.C 71-75 21 33.3 1 t r'.7I 17, 26.2 29 19.9 19 26.8 30 18.9 <45 years 1 4.3 4 11.1 8.5 5 6.6 5 7.1 9 8.0 ! 45-54 4 17.4 5 13.9 9 19.1 18 23.7 13 18.6 23 20.5 Sweden 55-64 5 :1.7~ 111 30.6 10 21.3 23 30.3 15 21.4 34 30.2 ~ 65-70 ~ 9 39.1 9 25.0 12 25.5 ? 2 15.8 21 30.0 21 18.8 71-75 4I 17.4 ; 19.4 12 25.51 i8 23.7 16 22.9 25 22.2 ~ <45 years 1 33.3( 2 14.3 .1 I . . 1 3.8 2 1.4 45-54 I United Kingdom 55-64 .; .I .~ 10 43.51 55 43.7 10 38.5 55 39.3 65-70 1 j 33.3' 71 50.0 ~ 9 39.1 40 31.7 10 38.5 47 33.6 ; ~ 71 •75 1 33.31 5 35.71 41. 17.4 31 24.6 5 19.2 36 25. i ; <45years 21 14.9. 40 7.5 28 5.5 60 5.9 49 7.5 100 6.5 45-54 28 19.9( 114 21.5 88~ 17.3 147 14.5 115~ 17.8 261 16.9 Total 55-64 47j 33.3) 205 38.6 163{ 32.0 347 34.3 210 32.3 552 35.8 65-70 271 19.1 104 19.6 127 25.0 ~ 267 26.4 154 23.7 371 24.1 71-75 181 12.81 68 12.8 103 20.2 190 18.8 121 18.6 258 16.7 2063593261

~_~~ u~ ~hildhood 0-18 yrs, Duratlon (years) (non overiappina) ALL CENTERS Lava€ ot oxpoauro Cases ~ Controls OR(1) 95% Cf OF2(21 95% CI OR(3) 95% CI ` OR(4) 95% CI OR(5) 95% CI Non axposed 25z 49s t.oo 1.00 1.00 1.00 1.00 ~ 0<C1110<a17 235 536 0.83 ( 0.65• 1.04) 0.87 ( 0.68- 1.12) 0.83 ( 0.63• 1.11) 0.83 ( 0.65- 1.05) 0.81 ( 0.62- 1.05) S7<C1UD 954 485 0.73 ( 0.56• 0.95j 0.76 ( 0.57- t.02) 0.77 ( 0.54• 1.09j 0.74 ( 0.56- 0.97j 0.70 ( 0.51- 0.96J frcludod/Trand~ 9 25 0.01 O.OY ~ 0.01 0.01 ( 0.01 AL CENTERS YYITH EDUCATIONAL LEVEL AND TYPE OF RESIDENCE NOn expOSmtl 149 350 1.00 1.00 ( 1•00 E 1.00 € 1.00 0<C1U0<.17 180 428 0.85 ( 0.64- 1.13) 0.85 ( 0.64- 1.13) 0.83 ( 0.63- 1.11) 0.85 ( 0.64- 5.14) 0.64 ( 0.62- 1.14) S7<C1U0 95 361 0.77 (, 0.54- 5.08) 0.77 ( 0.55- 1.09)~ 0.77 ( 0.54- 1.09) 0.78 ( 0.55- 1.11) 0•77 ( 0.52• 1.14) Eraluded/Trend 74~ 999 O.OY ~ 0.01 ~ 0.01 0.01 0.01 ALL CENTERS WITH DIETARY DATA Non expoietl 189 320 1.00 1.00 1.00 1.00 1.00 0<C1U0<17 200 418 0.80 ( 0.62- 1.04) 0.83 ( 0.64- 1.09) 0.82 ( 0.61• 1.11) 0.81 ( 0.62- 1.05)' 0.81 ( 0.62• 5.05) S7<C1UD 106 288 0.70 ( 0.51- 0.96) 0.75 ( 0.54- 1.04) 0.79 ( 0.53• t.18) 0.70 ( 0.51- 0.97)~ 0.70 ( 0.51- 0.96)~ fkcludsd/Trrnd f4 3C 0.01 € O•0> O,Of 0,01 € 0.01 ~ FRANCE Non exposed 0<CSUD<17 17<C1UD 32 37 1.00 1.00 1.00 € 1.00 1.00 20 44 0.55 ( 0.27- 1.12J 0.86 ( 0.39- 1.92) 1.33 { 0.44- 4.02) 0.52 ( 0.25- 1.08) 0.56 ( 0.27- 1.15) 24 70 0.39 ( 0.20- 0.77) 0.57 ( 0.27• 5.23) 1.01 ( 0.37- 2•75) ~ 0.39 ( 0.19- 0.77) 0.40 ( 0.20- 0.78) tkcludsd/Trend Y 0 0.01 0.0> ( 0.01 0.01 ( 0.01 GERMANY 1 No0 exposad O<C1UD<r17 S7<C1UD 1 29~ 74 1.00 1.00 1.00 1.00 1.00 t 35I S17 0.58 ( 0.31- 1.OSJ 0.60 ( 0.30- 1.20) ~ 0•58 ( 0.29- i.18) 0.62 ( ~ 0.33- 1.17) 0.61 ( 0.32- 1.16) i 10~ 35 0.65 ( 0.27- 1.57) 0.81 ( 0.32• 2.08) 0.87 { 0.33• 2.27) 0.71 { 0.29- 1 JS)~ 0.74 ( 0.30- 1.83) ~ I 6xc1 udid/Tnnd 2~ p s~ 0.15 i o.12 ~ 0.15 fi.15 € ~ 0.18 GERMANY2 Non exposed 0<CSUO<17 s2 63 1.00 1.00 1.00 1.00 1.00 79 98 0.82 ( 0.51- 1.33) 0.84 ( 0.52- 1.36) 0.81 { 0,50- 1.33) t 0.82 ( 0.51- i.32) 0.83 ( 0.51- i.33) r'zc1 uded/Trvnd 2 0.42 ~ 0.44 ! 0.39 0.41 0.42 GERMANY3 Non exposed 0<CSUD<17 95 18 1.00 1•00 1.00 1.00 1.00 15~ 33 0.55 ( 0,19- 1,59) 0.54 { 0.18• 1.57) 0.52 ( 0.17- i.62) 0.69 t, 0.23• 2.08) 0.46 ( 0.15 _1.40) .xcludad/Trend Yf ? 0.27 ~ 0.2f G.26 0.30 0.17 + ITALY 1 Non exposed 0<C1U0<17 11 a9 t.oo 1.00 1.0o t.oo t3 62 0.81 ( 0.32• 2.06) 1.05 ( 0.38• 2.86)~ 1.06 ( 0•38- 2.97) 0.79 ( 0.30• 2.10) 17<C1UD € 14 100 0.50 ( 0.20• 1.24) 0,71 ( 0.26- 1.95) 0.69 ( 0.24- 1.94)~ 0.53 ( 0.20• 7.38) s"xcludad/Trend~ 2 10 0. 13 I 0. 33 ~ 0. 34 0. 13 lTALY 2 Non exposetl ,'7 1,00 ( 1.00 1.00 9 7 ( 1.00 0<C1U0<17 3 34 1.39 ( 0.31- 6.26)f 1.70 ( -70. l 0.58 ( 0.2 0.05- 6.61) 1.57 ( 0.34- 17<C1UD 10 60 2.49 ( 0.79• 7.81)~ 5.01 ( 1.24-20.27)I. 2•27 ( 0.47-11.04) 2.66 ( 0.83• Exc1 uded/Trend ~ 0 2 ~ 0. 12 0. 02 0. 04 0. 10 ITALY 3 Non exposea 7 19 1.00 1.00 1.00 1.00 0<C1UD<17 2 6 0.67 ( 0.09• 4.73) 0.63 ( 0.08- 4.74) 0.47 ( 0,05• 4.88) 0.74 ( 0.10• 17<C1UD 7 25~ 0.58 ( 0.15- 2.21) 0.48 ( 0.11- 2.05) 0.39 ( 0.08- 1.97) 0.45 ( 0.11- €xcl uded/Trend Oi 0' 0.43 j 0.41 0.48 0. 27 PORTUGAL 1 Non exposea 24 15 1,00 1.00 0<C1UD<17 10 8f 0.79 l, 0.24- 2.57) 0.77 ( 0.24- 17<C1UD 15 13~ 0.75 ( 0.26- 2,14) 0.80 ( 0.27- Excl uded/Trsnd 0 3f 0.57 ~ 0. 54 PORTUGAL2 ~'J ~ ~ (li € 7.26)+ 8.50 ') 5.40) 1.85) 0.48 ( 0.05• 4.22) 0.64 ( 0.13• 3.11) 0.43 i 2.53) 2.37) Non exposmd i7 zs t.oo 1.00 1.00 0<C1UD<17 12 0.93 ( 0.29• 2,94) 0.86 ( 0.22- 3.49) 0.80 ( 0.24- 2.67) t7<C1UD ( 9 15 0.97 (, 0.33- 2,82) 0.59 { 0.18- 1.90) 0.97 { 0.33- 2.84) £rcluded/Trend~ 0~ 0 0.93 ~ 0.94 € O.B4 ~ SPAIN Non eXposetl 0<CSUD<17 17<C1U0 13! 32 1.00 1.00 1.00 1.00 1.00 21( 34 1.49 ( 0.63- 3.52) 1.19 ( 0.49- 2.88) 1.24 { 0.49- 3.15) 1.39 ( 0.58- 3.30) 1.48 ( 0.62- 3.55) 35 89 0.94 ( 0.44- 2.02) 0.77 t 0.35- 5.72) 0.89 ( 0.38- 2.04) 0.95 ( 0.44- 2.06) 0.94 ( 0.43- 2.05) frcltldad/Tr4ndi 2~ 4 0•68 0.75 ~ 0.98 t 0.67 0.70 ~ SYYEDEN Non mxposed ~ 29 as 1.00 1,00 1.00 1.00 0<C1UD<17 20 32 0.95 ( 0.45• 2.02j 0.92 ( 0.43- 1.96) 0.94 ( 0.44- 2.00) 0.93 ( 0.43- 9.98) ~ 17<C1UD 21 35 0.93 ( 0.45• 1.93) 0.87 ( 0.41- 1.82) 0.87 ( 0.42- 1.83) 0.86 { 0.41- 5.81) 0 5xclud~djTrend~ 0+ 0. 84 0. 70 I I E 0. 72 O. 69 UNITED KINGDOM NOn expOSetl 41 1.00 1.00 1.00 € 1.00 1,00 0<C1UD<17 10 56 1.01 ( 0.35- 2.89) 0.89 ( 0.30- 2.62) 0.85 ( 0.29• 2.51) 0.86 ( 0.29- 2.54) 1.09 ( 0.37- 3.20) i7<C1U0 ~ 9 43 1.19 ( 0.40• 3.57) 1.14 r, 0.37- 3.47)~ 1.06 ( 0.34- 3.28)~ 1.03 { 0.33• 3.22) t.21 ( 0.40- 3.64) ~ i j 2XCludtd/Trend 0 0 0.76 ~ 0.78 ~ 0.90 ; 0.83 0.74 (1) Model Irtuude sex, centor, sax'center and age (2) Model nckxlo sax contar, sax'cmntor, age and proportion oi residential type in the last 35 yrs (REUP) (?, Mqda! incWda sex, wMar, sazYenrx, aya, proportian af residentia! type In the tast 35 yrs (REUP) and edueationat tevel (EDUC) (4) Model includo sax, center, sex'tanter, age and duratlon of exposure to list A agents (OCLAY) (5) Model IncJudo aex, oenter, sex'CCnter, age and frequency consumption of vegetables NEGE)

Childhood D-98 yrs, ever exposed MEN ONLY twat ot • aure t Hon expoaed Exposed z G'~un z Co~trots ® Rf1 95'. Ct OR(2 95% C1 ORf3 95% C1 1 OR(4 95% CI E OR(5) 95% C( ( 65 201 1.00 1.00 1.00 1.00 1.00 75 321~ 0.79 ( 0.52- 1.21) 0.93 ( 0.59- 1.48) 0.73 ( 0.42- 1.28) 0.82 ( 0.53- 1.26) 0.76 ( 0.46- 1.24) ..~xc1udod/Trend 1~ ( 91 I € ( 1 Non exposed 187 295 1.00 1.00 1.00 1.00 1.00 l Exposed 314 700 0.77 ( 0.61. 0.98) 0.80 ( 0.62- 1.04) 0.82 ( 0.61- 1.10) 0.77 ( 0.61• 0.99)~ 0.77 ( 0.58- 1.01)~ &cluded/Tnn d 31 16 POPULATION BASED STUDIES Non exposed 162 326 1.00 1.00 1.00 1.00 1.00 Exposed 220 806 0.79 ( 0.61- 1.04) 0.85 ( 0.64- 1.12) 0.76 ( 0.55- 1.04) 0.82 ( 0.63• 1.08) 0.77 ( 0.57• 1.05) bYC1ud1dlTrtnd 6 18 ) HOSPITAL BASED STUDIES Non sxposod 93 129 1.00 1.00 1.00 1.00 1.00 Exposed 150 316 0.70 ( 0.49- 0.99) 0.72 ( 0.47• 1.09) 0.84 ( 0.50. 1.42) 0.67 ( 0.47- 0.96) 0.67 ( 0.43- 1.03) Ercluded/Trvnd~ 3 7 ~ j NITHOUTOCCAStONAL SMOKERS Hon axposeo 1 8 1 364 1.00 1.00 1.00 1.00 1.00 Exposed 299 723 0.90 ( 0.70- 1.14) 0.94 ( 0.72• 1.22) 0.90 ( 0.67- 1.21) 0.92 ( 0.72- 1.18)0.85 ( 0.64- 1.13) ~ c^xcludid/Trsnd~ 6 f7 Non oxposetl 67 114 1.00 1.00 1.00 1.00 1.00 Exposed 97 243 0.69 ( 0.46- 1.06)~ 0.90 ( 0.56- 1.44) 1.07 ( 0.59- 1.94) 0.67 ( 0.44- 1.04) 0.66 ( 0.41- 1.09) Excluded/Trand g l 4 AGE 66-64 YEARS Non sxpcaed Exposed 1 76 ?76 1,00 1.00 1.00 1.00 1.00 130 363 0.61 ( 0.56- 1.18) 0.78 ( 0.53- 1.16)~ 0.75 ( 0.48- 1.18) 0.78 ( 0.53- 1.14) 0.70 ( 0.45- 1.08) 4 Excludtd/Trandi f3 AGE 85+ YEARS Non exposetl Exposed 109 182 c"XCludsd/Trendl 41 HISTOLOGICALLY CONFIRMED DIAGNOSIS 206 4?5 8 1.00 0.80 ( 0.58- 1.11) 1.00 1.00 1 1.00 0.81 ( 0.58- 1.15)1 0.73 ( 0.49- 1.09)f 0.84 ( 0.60- 1.16) 1.00 0.83 ( 0.58- 1.19) Non expoaed 242 496 1.00 1.00 1.00 1.00 1.00 Exposed 376 9021 0.77 0.96) 0.83 ( 0.66- 1.04) 0.79 ( 0.61- 1.03) ( 0.63. 0.78 ( 0.63- 0.97)' 0.75 ( 0.59- 0.96) 5keludid/Trend 9 25 SQUAMOUS CELL CARCINOMA lion exposen 52 496 1.00 1.00 1.00 1.00 1.00 Exposed ~ 56 10211 0.53 { 0.35- 0.80) 0.53 ( 0.33- 0.84)~ 0.58 ( 0.35- 0.98) 0.51 ( 0.33- 0.78)y 0.50 ( 0.30- 0.81) Excludtd/Trand SMALL CELL CARCINOMA I Non expose0 28 496 1,00 1.00 1.00 € 1.00 1.00 i Exposod 41 1021 0.74 ( 0.44• 1.25) 0.75 ( 0.43• 1.29) 0.62 ( 0.35- t.09)~ 0.79 t, 0.46• 1.35) 0.63 ( 0.37- 1.08) EXCluded/Trandl 1 ADENOCARCINOMA Non exposetl 124 496 1.00 1.00 1.00 1.00 I 1.00 Exposed 204 1 021 0.80 ( 0.61- i.05) 0.88 ( 0.66- 1.18) 0.87 ( 0.62• 1.23) 0.81 ( 0.62- 1.06)f 0.78 ( 0.58- t.06' €xcludad/Trend ( 5~ ?5 I t ~ OTHER Non exposed Exposed 38 75 496 1.00 1021 0.96 ( 0.62- 1.46) Excluded/Trend! 21 251 >75% OF LIFESPAN IN RURAL AREA OR INTERMEDIATE CITIES 1.00 1.00 1.07 ( 0.67- 1.70)! 0.98 ( 0.58- 1.67) I Hon exposetl 113 89 1 1 , 00 1.00 1.00 1.00 1.00 Exposed 139 381 0.46- 0.89) 0.64 ( 0.60 ( 0.41• 0.88)~ 0.64 ( 0.46• 0.90) 0.64 ( 0.46• 0.89) 0.64 ( 0.45- 0.91) Excluded/Trandl 4 6 i € >75'~ OF LIFESPAN IN URBAN AREA Non exposed ~ 70 215 1.00 1 1.00 1.00 1.00 1.00 Exposed 170 481 1.17 (, 0.82• 1.68) 1.17 ( 0.82- t•68)I 1.17 ( 0.77- 1.78) 1.16 ( 0.81- 1.68) 1.14 ( 0.76- 1.73) € Excludad/Trend E 4 15~ I (1) Model inctude sox, cantnr, sex•center and ac~e (2) Modmt Isdude sex, conter, aex'center, a0e and proportx~ of residential type in the last 35 yrs (REUP) (3) Model Include sox, contar, sex'canter, a0e, proportion of residential type in the last 35 yrs (REUP) and educational level (EDUC) (4) Modal klelude sox, oant®r, sax'conter, a9e and duration of exposure to list A a9ents (OCLAY) (5) Modat krcluda sax, cantor, sax'centv , ago and frequanc7 wnsvmpt(vn of vegetaoles (VEGE) 5 1.00 f 1.00 0.96 ( 0.63- 1.47) 1 1.15 ( 0.70. 1.89) Risk estimates - Childhood 0-18 years , co

®SCU Occasionaf smoking, Cumulative exposure (packs/)ife6me) HISTOLOGICALLY CONFIRMED DIAGNOSIS Total Exposed Man Casot 149 36 Controls 566 145 All 732 181 Min € 03 109 4 0.05 0.05 0.25 '< .22 2.22 5.30 9.00 18.00 3.76 4.55 397 24 0.05 0.13 0.50 2.05 6.90 3.00 0.00 4.55[ 5.40 506 d5 0.05 0.13 0.50 2.05 6.50 13.00 20.00 4.40{ 5.24 YYOmen CJSts 513 93 406 14 0.03 0.05 0.15 0.75 3.00 9.00 18.25 2.90 4.77[ COntrois 950 179 0.03 0.05 0.15 1.00 4.00 11.40 19.20 3.11 4.63 ~ All 1607 272 1153 182 0.03 0.05 0.15 1.00 3.60 11.20 19.20 ~ 3.04 4.67 AN Casas 683 129 515 39 0.03 0.05 0.15 1.00 3.75 9.00 18.25 3.14 4.71 CoMtolm 1656 324 11441 188 0.03 0.05 0.25 1.20 5.20 12.50~ 20.00 5.04 3.76 AH 2339 453 16591 227 0.03 0.05 0.25 1.00 5.20 12.10 20.00 _ 3.58 4.95 fMw1 CLSAs 28 8 20 0 0.15 0.15 0.43 2.53 6.10 13.00 ! 13.00 3.91! 4.43 Controls 566 145 397 24 0.05 0.13 0.50 ~ 2.05 6.90 13.00 ~ 20.00 4.55 5.401 ` AH 808 153 417 38 0.05 0.15 0.50 2.05[ 6.90 13.00 20.00 4.52 5.341 Wqrttan Cas03 91 17 ?2 2 0.05 0.10 0.15 1.00 5.20 13.00 15.60 3.54 4.90 ConUok 950 179 747 24 0.03 0.05 0.15 1.00 4.00 11.40 19.20 3.11 4.63 A% 1173 196 819 158 0.03 0.05 0.15 1.00 4.00 11.40 19.20 3.15 4.65 AA Cases 125 25 92 a 0.05 0.15! 0.20 1.50 5.20 1.3.00 15.60 3.66 4.66 Controls All 1656 1781 324 349 1144 1236 188 196 0.03 0.03 0.05~ 0.05 0.25 0.25i 1.20 5.20_ 1.20 5.20[ 12.50 t3.00 20.00 20.00 3.76 3.75 5.04 5.00 M0n Cases 1 13 1 12 0 5.40 5.40 5.40 5.40 5.40 5.40 5.40 5.40 . Conlrols 566 145 397 24 0.05 1 0.13 1 0.50 2.05 6.90~ 13.00 20.00 4.55 5.40 594 Afl 146 409 39 0.05 0.13 0.50 2.22 6.90 13.00 20.00 4.56 5.38 Woman Cases 62 8 52 0.05 0.05 0.45 1.50 6.10 7.50 7.50 2.96 3.14 Conttofrt 950 179 747 24 0.03 0.05 0.151 1.00 4.00 11.40 19.20 3.11 4.63 All 1143 187 799 157 0.03 0.05 0.15 1.00 4.00 11.20 19.20 3.111 4.57 All CJeOf 81 9 ti4 8 0.05 , 0.05 0.50 2.40 5.40 7.50 7.50 3.23 3.05 ContfolS 1658 324 1144 188 0.03 0.05 0.25 1.20 5.20 12.50 20.OD 3.76 5.04 All 1737 333 1208 196 0.03 0.05 0.30 1.20[ 5.20 12.10 20.00 3.74 4.99 ADENOCARCINOMA Man Cases 79 20 $5 4 0.05 . 0.05 0.13 i.40 5.85 *,2.65 18.00 3.85 5.35 Controls 566 145 397i 24 0.05 0.131 0.50 2.05 6.90 13.00f 20.00 4.55 5.40 Atl 680 `:65 4S2f 43i 0.05) 0.10 0.50 2.00 6.75 13.00 20.00 4.47 5.38 -'.oman Cases 277 52 218 7 0.05 0.05 0.10 0.50 2.80 13.00 18.25 3.19 5.52 Controls 950 179 747 24 0.03 0.05~ 0.15 1.00 4.00 11.40 19.20~ 3.11 4.63I All 1357 231 965 161 0.03 0.05 0.13 1.00 3.75 12.00 19.20 3.13 4.84[ ~,5 Cases 351 72 273 16 0.05 0.05 0.10 0.70 3.68 13.00 18.25 3.37 544 Conlfola 1656 324 '144 188 0.03 0.05 0.25 1.20 5.20 12.50 20.00 3.76 5.04 1 All 2017 396 1417 204 0.03 0.05 0.25 1.00 5.20 13.00 20.00 3.69 5.i1 OTHER Ma0 Cases 29 7 22 0 1.00 1.00 1.25 2.50 5.20 7.80 7.80 3.13 2.49 Controls 666 145 397 24 ~ 0.05 0.13 0.50 2.05 6.90 13.00 20.00 4.55 5.401 All 610 152 419 39 0.05 1 0.15 0.50 2.221 6.83 13.001 20.00 ~ 4.49 5.31 N/omen C®sa9 83 16 64 3 0.03 0.05 0.13 0.55 2.35 3.00 5.00 1.26 1.47 Controls 950 179 747 24 0.03If 0.05 0.15 1.00 4.00 11.40 19.20 3.11 4.63 All 1162 195 811 156 0.031 0.05 0.15 1.00 3.60 10.40 19.20 2.96 4.49 AII Cases 116 23 86 0.03 0.10 0.25 1.20 2.70 5.00 7.80 1.83 1.98 Controls 1656 324 1144 188 0.03 0.05 0.25 1.20 5.20 12.50 20.00 3.76 5.04 All 1772 347 1230 195 0.03 0.05 0.25[ 1.20 5.20[ 12.00 20.00 3.63 4.91 >7340 OF LIFESPAN IN RURAL AREA OR INTERMEDiA7€ CITIES Men CJSaO 73 18 53 2 9.05 0.10 0.25 Z 22 5.00 7.80 13.00 2.98 3.44 COntf0li 212 48 157 7 0.05 0.20 0.63 3.30i 8.40 13.00 20.00 5.20 5.53 A11 301 66 210 25 0.05 0.13 0.50 2.80 6.00 13.00 20.00 4.59 5.11 Wom®n CJsBS 220 28 189 3 0.03 0.05 0.10 0.55/ 3.00 9.00 15.50 2.62 4.18 Controls ~ 361 74 285 2 0.03 0.05[ 0.451 1.00 i 3.60I 7.80 19.20 2.84 4.18 AI1 ~ 899 102 474 123 0.03 0.05 ` o.isl 1.00 3.501 7.80 19.20 2.78 4.16 AII C®sof 313 46 242 25 0.03 0.05 0.13 0.88 3.00 7.80 15.50 2.76 3.87 Controls 887 122 442 123 0.03 0.0 5 1 0.50 7.30[ 5.20 12.00 20.00 3,77 4.87 ' Atl 10001 168 684 148 0.03 00 . 5 0.43 1.231 5.10 12.00 1 20.00 3.49 4.63 '.7SY. OF LIFESPAN IN URBAN AREA .+n CSsOs II 48 17 30 1 0.05 0.05 0.25 1.55 4.00 16.30 18.00 3.92 5.43 Controls ~ 257 72 174 11 0.05 0.10 0.50 i.501 5.10 13.00 20.00I 3.80 4.93 All 305 89 204 12 0.05 0.10 0.50 1.50 5.00 13.00 20.00 3.82 5.00 NlCnian CJSeS 183 45 141 . 0.05 0.05 0.15 0.90 2.60! 7.00 15.60[ 2.29 3.64 ConUols 435 79! 339 '7 0.03 0.05 0.10 1.00 4.751 10.40 18.25{ 3,24 4.88 AII 650 1241 4801 46 0.03 0.05 0.13 1 0.95 3.35i 10.00 18.25` 2.89 4.48 Alt Casas 244 62I 171 11 0.05 0.051 0.15 1.00 3.60 7.80 18.00 2.74 4.22 Controls 711 151I 513 47 0.03 0.05 0.25 1.00 5.00 11.20 3.51 20.00 4.90 1 AII 955 213 684 58 0.03 0.05 0.20 `:.00[ 3.90 10.40i 1 20.00 3.28 _4_.72 P10 [ Qt ~ Median F P90 Max [ Mean Descriptive statistics -Occasional smoking

CIUN Childhood 0-18 yrs, Number of smokers ITALY 2 Total Exposcd Unexposed Excluded Min P10 01 Median 03 ~ P90 Max Mean j $td I MQn Cases 3 1 2 0 1.00 1.00 1.00 1.00 1.00~ 1.00 1.00 1.00 . ConIrGE ~ 97 65 41 1 1.00 1.00 1.00 1.00 p 2.00 p 3.00 4.001 1.56 0.90 All 100 56 43 1 1.00 1.00 1.00 i.00 2.00 3.00 4.001 1.55 0.89 WO~nCn Ci3E7 ~ 16 12 4 0 1.00 1.00 1.00 1.50 3.00 3.00 4.00 1.92 1.08 ControlS 76 39 36 1 1.00 1.00 1.00 1.00 2.00 3.00 4.00 1.67 0.93 All 92 51 401 1.00 1.00 1.00 1.00, 2.00 3.00 4.00 1.73 0.96 All Cases 19 13 6 0 1.00 1.00 1.00 1.00 3.00 3.00 4.00 i.85 1.07 Controls 94 77 2 1,00 i.00 1.00 1.00 2.00~ 3.00 4.00 1.61 0.91 Atl 107 83 2 1.00 1.00 1.00 1.00 2.00 3.00 4.00 1.64 0.93 ITAIY3 Mcn CasCS 1 0 1 o ~ COntrClS 12 5 7 0 1.00 1.00 1.00 1.00 1.00 3.00 3.00 1.40 0.891 ~ AA 13 5 8 0 1.00 ':.00 1.00 1.00 1.00 3.00 3.00 0.89~ 1.40 Women CaECi 15 9 6 0 1.00 1 .00 1.00 ?.00 1 .00 2.00 2.00 1.11 0.331 Controls 36 26 12 0 1.00 1.00 1.00 1.00 1.00 2.00 ~ 3.OOp 1.19 0.49 ~ All 63 35 18 0 1.00 1.00 1.00 p 1.00 1.00 2.00 3.001 1.17, 0.45 All Cases 16 9 7 0 ?.00 1.00 1.00 1.00 1.00 2.00 2.00 ?.11 0.33 COntrols 60 31 19 0 1.00 1.00 1.00 1.00 1.00 2.00 3.00 1.23 0.56 All 66 40 26 0 1.00 1.00 1.00 1.00 1.00 2.00 3.00 1.20 0.52 PORTUGAL 1 Men C.isCE 16 6 10 0 1.00 1.00 1.00 1.00 1.00 1.00/ 1.00 1.00 0.00 C~lttds 8 4 E 4 0 1.00 1.00 *,.00 1.50 3.00i 4.00 f 4.00 2.00 1.41 All 24 10 14 0 1.00 1.00 1.00 f 1.00 1.00` 3.00 4.00 1.40 0.97 WOR Cn C9sef 33 19 14 0 1.00 1.00 1.00 1.00 2.00 2.00 3.00 1.32 0.58 Controls 31 17 11 3 1.00 1.00 1.00 1.00 1.00 2.00 3.00 1.18 0.531 AIl 64 36 25 3 1.00 1.00 1.00 1.00 1.00 2.00 3.00 ".25 0.551 AA Cis®S 49 25 24 0 1.00 1.00 1.00 1.00 1.00 2.00 3.00 L 24 0.52 Controls 39 21 15 3 1.00 1.00 '.00 ~ 1.00 1.00 2.00 4.00 1.33 0.80 AI/ 881 46 39 3 1.00 1.00 1.00 1.001 1.00 2.00 4.00 1.28 0.66 PORTUGAL2 Men CBSes 10 4 Ci 0 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 0.00 Controls 17 7 10 0 1.00 1.00~ 1.00 1.00 1.00 3.00 3.00 1.29 0.76 Alt 27 11 16 0 1.00 1.00 1.00 `:.00 1.00 1.00 3.00 ` 1.18 0.60 WOn}Mt C2sCS 23 12 11 0 1.00 1.00 1.00 1.00 1.00 2.00 2.00 1.17 0.39 ConUGS 36 20 16 0 1.00 1.00 1.00 1.00 1.00 2.00 2.00 1.15 0.37 Afl 591 32 27 0 1.00 1.00I 1.00 1.00 1.00 2.00~ 2.00 1.16 0.37 All C71sef 33 16 17 0 1.00 1.00 1.00 1.00 1.00 2.00 2.00 1.13 0.34 COntrOls .`~i3 27 26 0 1.00 1.00 1.00 1.00 1.00 2.00 3.00 1.19 0.48 Afl ®6 43 43 0 `..00~ 1.00 1.00 1.00 i.00 2.00I 3.00 1.16 0.43 MCn Cases 6 4 2 0 1.00 1.00 ?.00 `:.00 2.50 4.00 4.001 1.75 1.50 Controls /3 12 1 0 1.00 1.00 1.00 1.00 1.00~ 2.00 2.00 1.17 0.39 All 19 16 3 0 1.00 1.00 1.00 '.00 1.00~ 2.00 4.00 1.31 0.79 WOn1Ctt CiseE 55 52 _ 11 21 1.00 1.00 1.00 1.00 1.00 2.00 3.00 1.29 0.61 COI1Ubls 146 111 31 4t.00 1.00 1.001 1.00 2.00 2.00 4.00 1.38 0.74 All 211 163 42 6 1.00 1.00 1.001 1.00 1.00 2.00 4.00 1.35 0.70 All C7ses 71 56 13 21 1.00 1.00 '.00 1.00 1.00 2.00 4.00 1.32 0.69 COntrOts 189 123 32 41 ~.00 1.00 1.00 1.00 2.00 2.00 4.00 1 1.36 0.71 Al 230 ?79 45 6 1.00 1.00 1.00 1.00 1.00 2.00 4.00 ?.351 0.71 SWEOEN Men C~s®s 23 16 71 0 1.00 1.00 1.00 1.00 1.50 2.00 4.00 1.38 0.81 ! CQntrots 36 ~ 20 16I 0 1.00 1.00 .00 '.00 1.00 2.00 2.00 2.00 ' .35 0.49 All ! 6fl 36 23 0 1.00 1.001 1.00 1.00 2.00~ 2.00 4.00 1.36 0.64 Woman Cases 47 25 22 0 1.00 1.00 1.00 1.00 2.00 2.00 3.00 1.40 0.65 COntr01E 76 47 29 0 1.00 1.00 1.00 1.00 2.00 2.00 3.00 1.32 0.591 All € 123 721 51 0 1.00 1.00 1.00 1.00 2.001 2.00 3.00 1.35 0.61 All Cases 70 41 29 0 1.00 1.00 1.00 1.00 2.00 2.00 4.001 1.39, 0.70 Controls 112 67 45 0 1.00 1.00 1.00 i.00 2.00 2.00 3.00i 1.331 0.56 All 162 108 74 0 ?.00 1.001 1.00 1.00 2.00 2.00 4.00 1.35 0.62 UNITED K1NG00M MCn Cases 3 2 0 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 0.00 Con4tols 14 10 4 0 1.00 1.00 1.001 2.00 2.00 2.00 2.00 1.70~ 0.481 17 12 5 0 '..00 1.00 1.001 2.00 2.001 2.00 2.00 1.s81 O.si Women Cases 23 17 4 0 1.00 1.00 1.00 1.00 1.00 4.00 5.00 1.41 1.181 ConUO~s 126` 39 37 0 ~.00 1.00 1.00 1.00 ~ 2.00 2.00 4.00 1.37 0.71 149 106 43 0 1.00 1.00 1.00 1.001 1.00 2.00 5.00~ 1.38 0.80 A!I Ca,cE 26 19 1 0 1.00 1.00 1.001 1.00 1.00 4.00 5.00 1.37 ;.12 Cdntras 140 99 ~ 41 0j 1.00 1.00 1.00 1.00~ 2.00 2.00 4.00 1.40 0.701 AA 168 118 48 0 ',.00 1.00 1.00 1.001 2.00 2.00 5.00 1.40 0.78 2063593334 I7acrrintiva statistir•_c - C`hilrihnnd f1-iR_vaarc -

F-_C 1 E F Childhood 0-18 yrs, ever exposed to father ALL CENTER3 twH ot.aposuts Non axposeC Exposed Casta Controls ORtt 95% C! ~ 252 496~ 1.00 333 898 0.76 ( 0.61- 0.94) fxcluded/Trendl 651 1481 ALL CENTERS YNTH EDUCATIONAL LEVEL AND TYPE OF RESIDENCE OR(2) 95% CI `; ®R(3) 95% Cl ( OR(4) 95% CI ( ®R(5)_ 95% Cf 1.00 1.00 1.00 1.00 0.82 ( 0.65- 1.03) 0.82 ( 0.63- 1.07) 0.76 ( 0.61- 0.95) 0.74 ( 0.58- 0.95) ~ ~ Non expos@o 149 350 1.00 1.00 1.00 1.00 1, 00 Exposed 1 247 695 0.82 ( 0.63- 1.07) 0.83 ( 0.63- 1.07) 0.82 ( 0.63- 1.07) 0.83 ( 0.64- 1.08) 0.82 ( 0.62- 1.09) :.xcluded/Trendl 1021 L 2931 A L CENTERS WITH DIETARY DATA Non @xposetl Exposed 189 320 00 1.00 ) 1.00 1. 1.00 1.00 272 643 0 . 74 ( 0.58- 0.94) 0.78 ( 0.61- 1.00)~ 0.83 ( 0.62- 1.10) 0.75 ( 0.58- 0.95) 0.74 ( 0.58- 0.95) Excluded/Trend~ 48 93 ( FRANCE Non @XpoS@tl 32 37 1.00 1.00 1.00 ' 1.00 1.00 Exposed 38 101 0.45 ( 0.24- 0.82) 0.65 ( 0.33- 1.30)~ 1.29 ( 0.49- 3.38) 0.43 ( 0.23- 0.80j 0.45 ( 0.24- 0.83) Excludad/Trond GERMANYI Nan e%p09tid 29 74 i.00 1.00 ; 1.00 1.00 1.00 EXposld 42 138 F 0.60 ( 0.33- 1.10) 0.64 ( 0.33- 1.27)i 0.63 ( 0.32- 1,27) ~ 0.64 ( 0.34• 1.18) 0.63 ( 0.33- 1.17)~ c"xcluded/Trend 51 17 Non @Xpos@tl 62 63 1.00 1.00 t 1.00 1.00 1.00 Exposed ~ 76 { S71 0.87 ( 0.54. 1.42) 0.90 ( 0.55- 1.47) 0.88 ( 0.53- 1.45)~ 0.87 ( 0.53- 1.41) 0.88 ( 0.54- 1.43) €xcluded/Trendi 4 ;31 E { Non @xpoa@o 15 18 1.00 1.00 1.00 1.00 1.00 Exposed 12 31 0.56 ( 0.19• 1.66) 0.54 ( 0.18- 1.61) 0.54 ( 0.17- 1.71) 0.70 ( 0.23- 2.17) 0.47 ( 0.15• 1.47) J Excluded/Trend 41 { €xcl uded/Trvnd l ITALY 2 Non @Xp03@d i Exposed ( 11i 201 €- 9~ Excluded/Trendf 11 ITALY 3 Non @xpos@d ~ 7 Exposed I 9 Excludid/Trend0~ PORTUGALI Non @xpos@a Exposed 24 12 fxcluded/Trendi 731 PORTUGAL2 Non @xpos@d I 17 Exposed i 15 2xcluded/Trend!!i <~ SPAI IN 49( 1.00 i 1.00 i 1.00 ; 1.00 1281 0.61 ( 0.85 ( 0.26- 1.43) 0.33- 2.18) 0.83 ( 0.32- 2.19)~ 0.59 ( 0.24- 1.46) I ~ ! iT 1 ~ 44 ~ ! 107 ~0 77 1.00 1.00 1.00 1.00 80 2.44 ( 0.78- 7.68) 4.97 ( 1.14-21.75) 1.83 ( 0.35- 9.61)~ 2.71 ( 0.84- 8.74) J ~ !6! ~ 19 1.00 1.00 1.00 1.00 1.00 30 0.61 ( 0.17- 2.18) 0.53 ( 0.13- 2.11)1 0.40 ( 0.08- 1.91) 0.51 ( 0,14• 1.93) 0.61 ( 0.13- 2.81) ° I i5 1.00 1.00 17 0.44 ( 0.15- 1.27) 0.46 ( 0.16- 1.36) 7 26 1.00 1.00 s 1.00 - 20 1.39 ( 0.52• 3.71) 0.85 ( 0.29- 2.48)~ ! 1.28 ( 0.47- 3.47) 7 Non exposed Exposed 13 50 32 1.00 03 ( 0 49- 2 117 1 15) 1.00 --- 1.00 ! 1.00 i 94 ( 0 84 { 0 39- 1 42- 2 09)1 1 02 ( 0 14)I 0 80)i 0 48- 2 1.00 1 04 ( 0 18) 49- 2 . . . . . . . . . . . . `I . . . Sxcluded/Trond 8~ € E 101 ~ SWEDEN Non exposed 29 Exposed ~ 31 Fxcluded/Trendl i01 UNITED KINGDOM 45 60 7i 1.00 ~00 { 0,77 ( 0.40- 1.49)~ 0.71 ( 0.36- 1.40)~ 1.00 0.72 ( 0.37• 1.40) 1.00 0.74 ( 0.38- 1.45) Non @xpos@d ~ ? 41 1.00 1.00 ! 1.00 1.00 1 1.00 Exposed 16~ 89 1.02 ( 0.38- 2.71) 0.91 ( 0.34• 2.48) 0.87 ( 0.32- 2.40)1 0.91 ( 0.34- "<.47)~ 1.02 ( 0.38• 2.75) Excluded/Trend~ 3~ 10 (1) Model Includo s@x, oant@r, sox'canter and age (2) Model Include sex, center, sex'cantor, age and proportion of residential type in the last 35 yrs (REUP) (3) Model &xludo sex, centar, sox'centor, age, proportion of residential type in the last 35 yrs (REUP) and educational level (EDUC) FA) ModeJ /nclude sex, canter, sex'centar, age and durat;on of exposure to list A aqents (OCLAY) . (5) Model Include sex, cantor, scx'conter, age and frequency consumption of vegetables (VEGE) Risk estimates - Childhood 0-18 years

a;IUN Childhood 0-18 yrs, Number of smokers MEN ONLY ( Totel Exposed Unexposedl Exduded Min P10 Q1 I Median 03 P90 ~ Max Mean Std Men C85c3 157 76 80 1 1.00 1.0 Of 9.00 1.00 1.00! 2.00 4.00 1.25 0.64 ConGCls ~ 580 335 236 9 1.00 1.00 i 1.00 1.00~ 2.00 f 2.00 1 5.00 1.42 0.74 AII j 737 411 316 10 1,00 I 1.00 1.00 1.001 2.00 2.00 5.00 1.39 0.73 WofiCn CB;fs 0 0 Controls 0 0 iiiiiiiiiJI iiiiii All 0 0 i .......I ~ ~ AII C95C4 157 76 1.00 1.00 1.00 1.00( 1,001 2.00 4,00 1.25 0.64 Controls 680 335 236 9 1.00 1.00~ 1.00 1,00' 2.00~ 2.00 5.00 1.42 0.74 All 737 411 316 10 ':.00 1.00f 1.00 1.00f 2.00 2.00 5,00 1.39 0.73 Men C85fS 0 0 0 0 Controls 0 0 0 0 An 0 0 0 o ~ i WOR1en C~.SC3 550 344 198 8 1.00 1.00 1.00 1.00 2.00 2.00 5.00 1.37 0.71 Conh019 1076 716 344 16 1.00 1.00 1.00 1.00 2.00 2.00 4.00 1.36 0.71 All 1626 1060 542 24 1.00 1.00 1.00 1.00 2.00 2.00 5.00 1.36 0.71 AN C35C5 550 344 198 88 1.00 1.00 4.00 i.00 2.00 2.00 1 5.00 1.37 0.71 Controls 1076 716 344 16 1.001 1.00 1.00 1.00 ' 2.00 2.00 1 4.00 1.36 0.71 AN 1626 1060 542 24 1.00( 1.00 € 1.00 1.001 2.001 2.00 5,00 1.36 0.71 POPULATION BASED STUDIES Men Cases 91 55 35 1 1.00 1.00 1.00 1.00 1.00 2.00 4.00 1.271 0.62 Controls 444 266 169 9 1.00 1,00 1.00 1 00 2.00 2.00 5.00 `:.43 0.77 All 535 321 204 10 1.00 1.00 1.00 1.00 2.00 2.00 5.00 1.40 0.75 Women Ca;eS 287 165 117 5 1.00 1.00, 1.00 1.00 2.00 3.00 4.00 1.39 0.75 Controls 506 340! 157 9 1.00 1.00 1.00 1.00 i 2.00' 2.00 4.00~ 1.41 0.75 A11 793 505~ 274 14 1.00 1.00 I 1.00 1.00 2.00i 3.00 4.00 1.41 0.75 A11 C8.c3 378 220 152 6 1.00 1.00 ':.00, ':.00 1.00 3.00 4,00 1:.36 0.72 Controls 950 606 326 18 1.00 1.00 1.00 1.00 2.00 2.00 5.00 1.42 0.76 AN 1328 826 478 24 1.00 :.00( 1.00 1.001 2.00 2.00 5.00 1.41 0.75 HOSPITAL BASED STUDIES Men CiSM 47 18 29 0 1.00 1.00 1.00 1.00 1.00 2.00 4.00 1.22 0.73 Controls 73 45 28( 0 1.00 1.00 1.00 1.00 1.00 j 2.00 4.00 1.31 0.67 AJI 120 63 57 0 1.00 1.00 1.00 1.00 ?.00 ( 2.00 4.00 1.29 0.68 Wofnetl C9sCs 199 132 64 3 1.00 1.00 1.00( 1.00( 1.00 2.00 3,00 1.25 0.53 ConVols 379 271 101 7 1.00 1.00 1.00 1.00( 1.00 2.00 4.00 1.271 0.64 All 578 403 165 10 1.00 1.00 1.00 1.001 1.00 2.00 4.00 1.26( 0.61 AN CASCS 246 150 93 3 1.00 1,00 1,00 1.00 1.00 2.00 4.00 1.25 0.55 ContrGs 452 316 129 7 1.00I 1.00 1.00 1.00 1.00 2.00 4.00 1.28 0.64 AIl 698 466 222 10 ':.00 1.00 1.00 1.00 1.00 2.00 4.00 1.27 0.62 Men CSSQs 112 55 56 1 1.00 1.00 1.00 1.00 1.00 2.00 4.00 1.27 0.71 Conir0ls 406 228 173 5 1.00I 1.00 1.00) 1.00 2.00 2.00 4.00 1.42 0.71 All 518 283 229 6 1.00 1.00 `:.00 1.00 2.00 2.00 4.00 1.391 0.71 women Cascs 430 275 150 6 1.00 1.00 1.00 1.00 2.00 2.00 4,00! 1.37 0..70 COntl0lf 810 525 273 12 1.00 i.00 1.001 1.00 1.00~ 2.00 4.00 1.351 0.70 All 1240 800 423 17 1.00 1.00 1.00 1.00 2.00 2.00 4.00 1.36 0.70 A11 CiSes 542 330 206 6 1.00 1.00 1.00 1.00 1.00 2.00 4.00 '..36 0.70 Controls 1216 753~ 446 17 1.00 1.00 1.00 1.00 2,00( 2,00 4.00 1.37 0.70 Af 1758 1083 652 23 1.00 1.00 1.00 1.00 ^.00! 2.00 4.00( 1.37 0,70 AGE <55 YEARS Men Ceses I 57 31 26 0 1,00 1.00 1.00 1.00 2.00 2.00 4.00 1.42 0.76 ` Controls I 172 100 72 0 1.00 ?.00 i.00 7.00 2.00~ 3.00~ 5.00 1.53 0.9C All 229 131 98 0 1.00 1.00 i,001 1.00 2.00 3.00 5.00 1.54 0.87 Women Cases 138 82 55 1 1.00 1.00 1.00 1.00 2.00 2.00 4.00I€ 1.37 0.69 Controls 254 159 91 4 1.00 1.00 1.00 1.00 2.00 2.00 4.001 1.38 0.71 All 392 241 146 5 1.00 1.00 1.00 1.00 2.00 2.00 4,00( 1.37 0.7C AII Ciscs 195 113 81 1 1,00 1.00 1.00 1.00 2.00 2.001 4.00 1.38 0.71 CCnlr0ls 426 259 163 4 1.00 1.00 1.00 1.00 1 2.00 3.00[ 5.00 5.46 0.75 All 6211 372 244 5 1,00 '.00 1,00 1.00 2.00 2.00 5.00~ 1.43 0.7 Men C85c3 52 25 26 1,00 1.00 1.00 1.00 1.00 1,00 2.00 1.08 0.28 ConVGs 216 118 92 6 1.00 1.00 1.00 1.00 I 1.00 2.00 4-00 1.33 0.67 AN 268 143 118 1,00 ':.00 1.00 ?.00 ?.00 2.00 4.00 1.291 0.62 wORSen ~ Gses 176 115 58 3 1.00 1.00 1.00 1.00 2.00 2.00 4.00 1.37 0.6~ Conlroia 359 ` 250 102 1,00 1.00 1.00 1.00 2.00 2.00( 4.00 1.38 0.6, AN 936 365 160 10 1,00 1.00 1.00 1.00 2.00 2.00 4.00 1.38 0.69 All Cases 226 140 84 4 1,00 1.00 1.00 1.00 1.00 2.001 4,00 1.32 0.65 Conlrols 575 368 194 13 1,00 1.00~ 1.00 1.00 2.00 2.00 4.00 1.37 0.6E AN 803 508 278 17 1.00 1.00I 1.00 1.00 2.00 2.00 4.00 1.35 0.67 AGE 65+ YEARS Men CBses € Controls AH woman Cascs Conlro+s All All Cises Controls AN 48 20 28 0 1.00 1.00 1.00 1.00 1.00 1.50 4.00 1.20 - 0.7C 192 117 1 72 3 ,00 1,00 1.00 1.00 2.00 2.00 4.00 1.38 0.64 240 137 100 3 1.00 1.00 1>00 1.00 2.00 2.00 4.00 1.361 0.6E 236 147 85 4 1.00 1.00 1.00 1.00 1.00 2.00 5.00 1.37 0.7= 463 307 151 5 1,00 1.00 1.00 00 1.00 2.OOi 4.00 1.33 0.7£ 699 464 236 9 1.00 1.00 1.00 1.00 1.00 2.00 I 5.00~ 1.34 0.72 284 167 113 41 1.00 1,00 1.00 1.00 1.00 2.00 5.00 1.35 0.74 655 424 223 3 i.00 1.00 1.00 1 00I 1.00 2.00 4.00 1.35 0.7C 939 591 336 12 1.00 1.00 1.00 . 00 1.00 2.00 5.00 1.35 0.7. d_fi_9.R_v- . .

D _®SU D Occasional smoking, Duration (years) (non overfapping) TTiE?1 ONLY Lavalo! oaurs NE., USUD<5 $<0SUO<17 17<0SUD 1 Caaea i Controls OR 1 95% C! ' OR 2) 95% C! OR(3 95% C! OR(4 95% CI OR(5 95% CI 125 467 1.00 1.00 1.00 1.00 1.00 7 27 0.94 ( 0.36- 2.46) 1.16 j 0.42- 3.23) 1.74 j 0.51- 5.92) 0.93 ( 0.35- 2.44) 0.75 ( 0•22• 2.54) 1 5 10 1.15 ( 0.34- 3.82) 1.32 ( 0.39- 4.49) 0.00 ( 0.00-99.99) 1.07 ( 0.31- 3.66) 0.64 ( 0.15- 2.75) Excludod/Trend~ 4f 27 0.85 0.72 0.69 0.93 0.86 tNOMEN ONLY NE., 0SU0<5 444 5<0SUD<17 19 17<OSUD 12 811 1.00 1,00 ~ 1.00 1.00 1.00 33 ~ 1.26 ( 0.69• 2.29) 1.00 ( 0.51- 1.94)( 1.29 ( 0.54- 3.11) 1 1.34 ( 0.73- 2.46) 1.14 ( 0.57- 2.29) 24 1.01 ( 0.49- 2.10) ~ 1•OS ( 0.50- 2.17)~ 1.15 ( 0.42- 3.11) 1 1.02 ( 0.49- 2.12)l 1.06 ( 0.49- 2•32)~ Ercludad/Trand 941 143 1 0.82 ~ 0.75 ~ 0.69 ~ 0.82 ~ 0.81 ~ POPULATION BASED STUDIES OSUOc5 NE., 352 88a 1.00 " 1.00 1.00 1.00 1.00 5<OSUD<77 6 38 1.46 ( 0.76- 280) . 1.35 ( 0.68• 269) 1.70 ( 0.70- 4.12) 1.49 ( 0.77- 2.87) 1.29 ( 0.58- 2.87) t7<OS(10 9 22 0.84 ( 0.36- t .95j 0.87 ( 0.37- 2.01) 0.37 ( 0.04• 3.13) 0.84 ( 0.36• 1.95) 0.83 ( 0.33- 2.06) cxcludmd/Trsnd 1 6 0.94 , 0.95 0.97 0.89 ~ 0.94 H0.SPITAL BASED STUDIES NE., OSUD<5 277 394 1.00 1.00 g 7.00 1.00 1.G0 5<OSUO<17 10 22 0.84 ( 0.37- 1.88) 0.68 l, 0.26• 1.78)1 1.07 ( 0.31- 3.69) 0.87 ( 0.39• 1.98) 0.77 ( 0.31- 1.95) '.7<OSUD 8 12 1.39 ( 0.55- 3.51) 1.47 ( 0.58- 3.75)!!f 1.38 ( 0.44- 4.35) 1.40 ( 0.55• 3.53) 1.16 ( 0.41- 3.24) ~YCludad/TiYnd ;1 24 0.58 0.54 ~ 0.53 0.57 ~ 0.59 ~-~---_.-€.-- - ----~ 2063593292 fxcluded/7/Yndl 4861 1104 AG€ <55 YEARS NE,, OSUD<S 5<OSUD<.17 17<0SUD ( fxcludad/Trrndi 157 309 1.00 1.00 1.00 1.00 1.00 6 23 0.52 ( 0.19- 1.40) 0.40 ( 0.12- 1.26) 0.99 ( 0.28- 3.50) 0.49 ( 0.18- 1.35) 0.63 ( 0.21- 1.91) 4 18 0.40 ( 0.13- 1.24)i p 0.47 ( 0.15- 1.49) 0.26 ( 0.03- 2.17) 0.41 ( 0.13- 1.28) 0.50 ( 0.15- 1.63) 4 11 0.07 II 0.07 ~ 0.07 0.07 0.07 AGE 55-64 YEARS NE•, 05U0<5 5<OSUD<.17 17<0SU0 182 472 1.00 - 1.00 1.00 1.00 ' 1.00 8 18 1.28 ( 0.51- 3.22) 0.90 { 0.3?• 2,65) 1•02 ( 0.25- 4.09) 1.39 1 0.54- 3.53) 0.96 ( 0.33- 2.81) 8 S 3.29 ( 0.95-11.39) 3.26 ( 0.94•11.34) 1.52 ( 0.26- 8.79) 3.32 ( 0.96-11.49) 2.68 ( 0.63-11.45} E'xcluded/Trentl 14 57! 0.05 0.05 0.05 0.05 0.05 AGE65+YEARS NE., 0SUD<5 5<05U0<.17 17<0SUD 236 497 1.00 1•00 1.00 ( 1.00 1.00 12 19 2.31 j 1.00- 5.32) 2.32 ( 0.96- 5.60) 2.43 ( 1.04- 5.69) 2.63 ( 0.81- 8.55) 1.59 ( 0,58- 4.38) 7 11 1.11 ( 0.40- 3.10) 1.07 ( 0.38• 3.01) ~ 1.64 f 0.36- 7.54) 0.98 ( 0.34- 2.83) 0.93 ( 0.31- 2.78) FXCIudBd/TtQnd~ 201 1021 0.48 0.51 ~ 0.43 l 0.61 0.56 HlSTOLOGICALLY CONFIRMED DIAGNSIS NE., OSUD<5 552 1278 5<0SU0<17 26 60 17<OSUD 17 34 Fxcludid/Trsndl 32! 170 SQUAMOUS CELL CARCINOMA NE., OSUD<.5 92 1278 WSUD<17 60 17<0SU0 2 j 34 Exo1 udtd/Trand SMALL CELL CARCINOMA B 1.00 1,18 ( 0.71- 1.95) 1.09 ( 0.58• 2.02) 0.69 1.00 ~ 1.00 1.06 ( 0.61- 1.85)I 1.40 ( 0.68- 2.86) 1.11 ( 0.60- 2.07)If 0.91 ( 0.35- 2.39) ! 0.68 1.00 1.00 2.31 ( 0.96- 5.57) 2.61 ( 1.03• 6.63) 1.05 ( 0.24• 4.69) 1.02 ( 0.23• 4.58) 1701 0.52 ~ 0.54 i ~ 0.62 1.00 3.68 ( 1.14-11.88) 1.10 ( 0.14- 8.98) 0.44 i.00 ( i:Oo 1.22 ( 0.73- 2.03) 1.03 ( 0.57- 1.88) 1.08 ( 0.58- 2.01) 0.95 ( 0.48- 1.88) 0.73 ~ 0.69 1.00 1.00 2.48 ( 1.02- 6.06) 1.96 ( 0.64- 5.96) 1.07 ( 0.24- 4.77) 0.57 1, 0.07- 4.49) 0.52 i 0.52 NE., OSUO<.8 59 278 1.00 1.00 1.00 1.00 1.c0 5<0SU0<17 3 60 2.02 ( 0.55• 7.42) 1.28 ( 0.27- 6.06) 2.56 ( 0.50-13.04) 2.05 ( 0.55- 7.61) 2.33 ( 0.61- 8.86) 17<0SUD 0 34 0.00 ( 0.00•99.99) 0.00 ( 0.00-99.99) 0.00 ( 0.00-99.99) 0.00 ( 0.00-99.99) 0.00 ( 0.00-99.99) fxclud#d/Trlndl 81 170I 0.67 ! 0.62 ~ 0.68 ! 0.67 0.67 ADENOCARCINOMA NE., OSUO<5 299 1278 1.00 1.00 1.00 1.00 1.00 5<OSUO<17 15~ 60 1.16 ( 0.62• 2.16) 1.23 ( 0.48- 3.17) 0.96 ( 0.48- i.95) 1.20 ( 0.64- 2.26) 0.89 ( 0.42- i.90) t7<OSUD 9 34 0.87 ( 0.40• 1.90) 1 0.91 ( 0.41- 2.00) 0.24 { 0.03- 1.86) 0.84 ( 0.38- 1.86) 0.82 ( 0.36- 1.90) fxcludad/Trend 10 ~ 170 0.82 0.85 i 0.90 0.75 [ 0.79 OTHER NE,, 0SU0<5 5<0SU0<17 17<OSUD 60 0,21 ( 0.03- 4 1,79 ( 0.70- fxcluded/Trendl 61 170 0.42 >75% OF UFESPAN IN RURAL AREA OR INTERMEDIATE CITIES NE,, 05UD<5 220 422 1.00 5<0SU0<•17 7 23 0.68 ( 0•27• 17<OSUD I 6 12~ 0.96 ( 0.34- fxclud.d/Trend l 3 1181 0.75 >755G OF LIFESPAN IN URBA N AREA tiE,, OSUO<5 I 216 626 1.00 5<0SU0<17 11 30 1.29 ( 0.59• 17<OSUD 1 8 18 1 09 ( 0.44• Excludad/Trend 9 071 0.74 1 100 . 100 . ~ 100 . ( 100 . 1.60) 0.25 ( 0.03- 1.89) 0.00 ( 0.00•99.99)~ 0.21 ( 0.03- i.60)( 0.29 ( 0.04- 2.22) 4.62) 1.94 ( 0,75- 5.02) 2.97 ( 0.92- 9.57)~ 1.80 ( 0.70- 4.64) 1.57 ( 0.56- 4.42) 0.40 I 0.40 ~ 0.40 0.40 1.00 1.00 1.00 1.00 1•68) 0.68 ( 0.27- 1.68) 1.43 ( 0.46- 4.48) 0.70 ( 0.28- 1.74) 0.79 ( 0.31- 2.00) 2.72) 0.96 ( 0.34- 2.72) 1.02 ( ~ 0.18- 5.76) 0.99 ( 0.35- 2.82) 0.68 ( 0.20- 2.30) 0.75 0.84 (! ( 0.75 0.73 1.00 i 1.00 1.00 1.00 2.80) 1.29 ( 0.59- 2.80) 1.17 ( 0.41• 3.38) 1.30 ( 0.59- 2.88) 0.98 ( 0.37- 2.61) 2.70) 1.09 ( ~ 0.44- 2.70) 0.81 ( 0.21- 3.09) 1.07 ( 0.42- 2.69) 1.31 ( 0.49- 3.48) ~ 0.73 0.78 0. 73 (1) Model (nclude sex, Oenter, sex-center and age (2) Model uulude sex, center, sex'center, age and proportion of residen(ial type in the lasl 35 yrs (REUP) (3) Alvde) lndude scx, cenlcr, srx'center. age, proportion of residential type in the last 35 yrs (REUP) and educational level (EDUC) (4) Modal Includa sex, center, sex'center, age and duration of exposure to list A agents (OCLAY) (5) Model Cndude sex, center, sex'oenter, age and frequency consumption of vegetables (VEGE) 1278 1.00 Bisk-es=ate - Occasionaf smoking 1

C_®SU D Occasional smoking, Duration (years) (non overlapping) Controls ~ OR 1 95% Cl OR(2) 95% Cl OR(3 95% Cl OR 4 95% Cl OR(5) 95% Cl Non Oxposoo 95 350 1.00 1.00 1.00 1.00 1.00 0<OSUD<nb 30 117 0.65 ( 0.37- 1.14) ~ 0.71 ( 0.39- 1.32) 0.42 ( 0.16- 1.06) 0.64 ( 0.36• 1.14) 0.51 ( 0.25- 1.04) 5<OSUO<17 7 27 0.82 ( 0.31- 2.18) 1.03 ( 0.36• 2.94) 1.48 ( 0.43- 5.07) 0.80 ( 0.30- 2.15) 0.59 ( 0.17- 2. 09) 17<OSUD 5 10 0.92 ( 0.27- 3.17) 1.11 ( 0.31- 3.93) 0.00 ( 0.00-99.99) 0.85 ( 0.24- 3.03) 0.45 ( 0.10- 2.03) 27 0.94 0.81 0.78 0.98 0.95 Non .xpos.d 376 682 1.00 1.00 t.0o t.oo 1.00 .00 0<OSUD<5 ~ 66 129 1.04 ( 0.72- 1.51) 1.15 ( 0.78- 1.70) 1.31 ( 0.79- 2.15} 1.09 ( 0.75- 1.58) 0 ( 0.60- 1.41) b<OSUO<17 19 33 1.27 ( 0.69- 2.34) 1.04 ( 0.53- 2.05) 1.38 ( 0.57- 3.36) 1.38 ( 0.74- 2.56) 1.11 ( 0.55- 2.25) 17<OSSJD 12 24 1.03 ( 0.49- 2.14) 1.09 ( 0.52- 2.29) 1.20 ( 0.44- 3.27} 1.05 ( 0.50- 2.20) 1.03 ( 0.47- 2.29) Ez0ludld/Trend 34 1 143 0.81 0.75 0.67 0.81 0.81 POPULATION BASED STUDIES Non expo=ed 294 716 1.00 1.0o t.o0 1.00 1.00 0<OSUD<5 58 166 0.96 ( 0.64- 1.43) 0.97 ( 0.65- 1.46) 0.89 ( 0.52- 1.53) 0.96 ( 0.64- 1.44) 0.87 ( 0.54- 1.39) 5<OSUD<17 16 38 1.45 ( 0.75- 2.79) 1.34 ( , 0.66- 2.70) 1.67 ( 0.69- 4.07) 1.47 ( 0.76- 2.87) 1.23 ( 0.54- 2.78) 17<OSUD 9 22 0.83 ( 0.35- 1.95) 0.86 ( 0.36- 2.03) 0.36 ( 0.04- 3.09) 0.82 ( 0.35- 1.95) 0.77 ( 0.30- 1.97) Ezcluded/rrend 1 61 0.92 0.93 0.98 0.87 0.92 HOSPiTAL BASED STUDIES Non exposed 179 314 1.00 1.00 1.00 1.00 ` 1.00 0<0SU0<5 38 80 0.79 ( 0.49- 1.30) 1.01 ( 0.58• 1.76) 0.96 ( 0.47- 1.96)~ 0.84 ( 0.51- 1.38) I 0.66 ( 0.37- 1.16) 5<OSUD<n17 10 22 0.78 ( 0.34- 1.77) 0.69 ( 0.26- 1.83) 1.05 ( 0.29- 3.75)!!! 0.82 ( 0.36- 1.89)!!!I 0.67 ( 0.26• 1.72) 17<OSUD 8 12 1.31 ( 0.52- 3.36) 1.47 ( 0.57• 3.81) 1.37 ( 0.43- 4.35)( 1.34 ( 0.53- 3.40) 1.05 ( 0.37- 2.97) E.reludid/Trand 11 24 0.62 0.58 0.56 0.61 ~ 0.63 a WiTHOUT OCCASIONAL SMOKERS Non .xposod Excludtd/rrtnd AGE t55 YEARS Non exposed 0<0SUD<6 StOSUD<17 17<OSUD Excludtd/rrend AGE 55-64 YEARS Non expasea 0<0SUD<rs 5<0SUD<17 17<0SU0 Excluded/Trend AGE G5+ YEARS 115 225 1.00 1.00 1.00 1.00 1.00 36 64 0.85 ( 0.49- 1.46) 0.93 (, 0.51- 1.70) 0.83 ( 0.39- 1.79) 0.88 ( 0.50- 1.55) 0.76 ( 0.40- 1.44) 6 23 0.49 ( 0.18• 1.34) 0.39 ( 0.12- 1.26) 0.94 ( 0.26- 3.39) 0.47 ( 0.17- 1.32) 0.57 ( 0.18- 1.77) 4 18 0.37 ( 0.11- 1.19) 0.45 ( 0.14- 1.49) 0.25 { 0.03- 2.09) 0.38 ( 0.12- 1.24) 0.44 ( 0.13- 1.49) 4 11 0.05 0.07 0.07 ~ 0.07 0.07 148 383 1.00 1.00 1.00 1.00 1.00 34 89 1.25 ( 0.74- 2.14) 1.27 ( 0.73- 2.22) 1.04 ( 0.52- 2.09) 1.27 ( 0.74- 2.18) 1.16 ( 0.61- 2.20) 8 ' 18 1.39 ( 0.54- 3.55) 1.00 ( 0.33- 2.98) 1.03 ( 0.25- 4.17) 1.51 ( 0.58- 3.93) 1.02 ( 0.34- 3.07) 6 5 3.58 ( 1.02•12.55) 3.56 ( 1.01-12.59) 1.53 ( 0.26- 8.90) 3.62 ( 1.03-12.73) 2.86 ( 0.65-12.51) 14 ' 57 0.05 0.04 0.04 0.04 0.05 Non exposed 210 424 1.00 1.00 1.00 1.00 1.00 0<0SUD<5 26 73 0,70 1:00 ( 0.40- 1.23) 0.80 ( 0.44- 1.44) 0.97 ( 0.43- 2.20) 0.75 i 0.42- 1.32) 0.52 ( 0.27- 0.99) 5<0SU0<17 12 19 2.14 ( 0.92- 4.98) 2.20 ( 0.90- 5.38) 2.62 ( 0.80- 8.58) 2.27 ( 0.96- 5.39)~ 1.35 ( 0.48- 3.79) 17<0SUD 7 11 1.02 ( 0.36- 2.87) 1.02 ( 0.36- 2.88) 1.64 ( 0.36- 7.54) 0.92 ( 0.31- 2.67)i 0.78 ( 0.26- 2.38) Excluded/Trend .20 102 0.53 0.57 0.48 1 0.67 tl 0.63 HISTOLOGICALLY CONFIRME D DIAG NO SIS Non exposetl ~ 460 1032 1.00 1 00 1.00 1.00 1.00 0<0SUD<5 92 246 0.88 ( 0.64- 1.20) 0.97 ( 0.69- 1.34) 0.94 ( 0.62- 1.44) 0.91 f, 0.66. 1.24) 0.78 ( 0.54- 1.11) ~ 5<0SU0<17 26 60 1.13 f, 0.68- 1.90) 1.05 ( 0.60- 1.85) 1.38 l, 0.67- 2.84)f 1.18 ( 0.70- 1.99) 0.94 ( 0.51- 1.74) 17<0SU0 17 34 1.04 ( 0.55- 1.95)I 1.09 ( 0.58- 2.06) 0.90 ( 0.34- 2.37) ' 1.04 ( 0.55- 1.96) 0.86 ( 0.43- 1.73) Excluded/Trendl 32! 170I 0.73 i 0.73 ! 0.66 0.78 0.73 SQUAMOUS CELL CARCINOMA Non exposatl 77 1032 1.00 1.00 1.00 1.00 1.00 0<0SU0<5 15 246 1.32 ( 0.68• 2.55) 1.40 ( 0.68- 2.87) 1.28 ( 0.52- 3.17) 1.41 ( 0.72- 2.74) 1.35 ( 0.63- 2.89) 5<OSUDtr17 60 2.50 ( 1.02- 6.16) 2.88 ( 1.11- 7.51) 3.85 ( 1.18-12.58) 2.75 ( 1.10- 6.89) 2.16 ( 0.69- 6.78) 17<0SUD 2 34 1.15 (, 0.25- 5.17) 1.13 ( 0.25- 5.16) 1.15 { 0.14- 9.36) 1.19 ( 0.26- 5.37) 0.63 ( 0.08- 4.99) Zxcludtd/Trend 8 170 0.50 0.51 0.47 0.49 0.50 SMALL CELL CARCINOMA Non expose0 53 1032 1.00 1.00 1.00 1.00 1.00 0<0SUD<5 1 8 246 0.83 ( 0.32- 2.15) 0.89 ( 0.34- 2.33) 0.66 ( 0.21- 2.06) 0.69 ( 0.25- 1.93) 0.74 ( 0.26- 2.08) 5<0SUD<a17 3 60 1.94 ( 0.52- 7.23) 1.25 ( 0.26- 5.99) 2.37 ( 0.46-12.22) 1.90 ( 0.50- 7.15)~ 2.19 ( 0.57- 8.42) 17<OSUD 34 0.00 ( 0.00•99.99) 0.00 ( 0.00-99.99) 0.00 ( 0.00-99.99) 0.00 ( 0.00-99.99) 0.00 ( 0.00-99.99) E-xcl udtd/ rrand 170 0.64 0.60 0.65 0.64 1 0.65 ADENOCARCINOMA Non exposed 245 1032 1.00 1.00 1.00 1.00 1 1.00 0<OSUD<.5 54 246 0.87 ( 0.59• 1.28) 0.93 ( 0.62- 1.41) 0.93 ( 0.54- 1.60) 0.93 ( 0.63- 1.37) 0.73 ( 0.47- 1.14) b<OSUD<.17 15 60 1.10 ( 0.58- 2.09) 0.94 ( 0.46- 1.93) 1.21 ( 0.47- 3.14) 1.17 ( 0.61- 2.24) 0.80 ( 0.37• 1.72) 17<OSUD 9 34 0.82 ( 0.37- 1.82) 0.89 ( 0.40- 1.98)~ 0.24 ( 0.03- 1.84) 0.82 ( 0.36- 1.83) 0.73 ( 0.31- 1.72) Excluded/7rend 10 1 170 0.78 O.B1 1 0.86 0.71 ~ 0.75 OTHER Non exposed 85 1032 1.00 1.00 1.00 1.00 t 1.00 0<0SU0<5 ~ 17 246 0.67 ( 0.36• 1.23) 0.85 ( 0.45- 1.60) 0.82 ( 0.36- 1.88) 0.69 ( 0.37- 1.28) 0.65 ( 0.32- 1.29) 5<05UD<17 ~ ' 60 0.19 t 0.03- 1.43)I 0.24 ( 0.03- 1.81) 0.00 ( 0.00•99.99) 0.19 { 0.03• 1.44) 0.25 ( 0.03- 1.94) 17<oSUO 1 6~ 34 1.56 ( 0.59- 4.12) f 1.83 ( 0.69- 4.86) 2.86 ( 0.88- 9.30)' 1.58 ( 0.60- 4.19) 1.34 ( 0.46- 3.89) axcluded/rrend~ u 170 0.46 !! ( 0.44 0.43 EEEI 0.44 0.44 >75% OF LIFESPAN IN RURAL AREA OR INTERMEDIATE CITIES Non exposed 186 332 1.00 1.00 1.00 1.00 1.00 0<OSUO<5 34 90 0.80 ( 0.47- 1.34) 0.80 ( 0.47- 1.34)' 0.67 ( 0.34- 1.33) 0.76 ( 0.44- 1.29) 0.67 ( 0.38- 1.17) v<OSUD<17 7 231 0.63 ( 0.25- 1.58) 0.63 ( 0.25• 1.58) t/ 1.29 ( 0.41- 4.08) 0.64 ( 0.25- 1.61) 0.69 ( 0.26- 1.78) 17<OSUD 6 12 0.87 ( 0.30- 2.52) 0.87 ( ! 0.30- 2.52) 0.91 ( 0.16- 5.18) 0.88 ( 0.30- 2.57) 0.57 ( 0.16- 1.98) cxcludedtrrend 23 1 718 0.71 0. 71 1 0.80 1 0.77 0.69 ~ >75% OF LIFESPAN IN URBAN AREA Non exposed 171 513 1.00 1.00 1.00 1.00 1.00 0<oSUD<5 45 113 1.31 ( 0,82- 2.09) 1.31 ( 0.82- 2.09) 1.33 ( 0.73- 2.43)1 1.34 ( 0.83- 2.15) 1.32 (, 0.74- 2.34) 6<OSUD<17 11 30 1.40 ( 0.64- 3.07) 1.40 ( 0.64- 3.07) 1.23 ( 0.43- 3.58) 1.43 ( 0.64- 3.21) 1.08 ( 0.40- 2.94) 17<OSUD 8 18 1.17 ( 0.47- 2.94) 1.17 ( 0.47- 2.94) 0.83 ( 0.22- 3.18) 1.16 ( 0.46- 2.93) 1.42 ( 0.53- 3.82) Excludtd/rrend 9 37 0.69 0.69 0.68 0.74 t 0.69 (1) Model Include sex, center, sex'center and age (2) Model Incfude sex, center, sex'center, age and proponion of residential type in the last 35 yrs (REUP) (3) Mode) (ndude sex, center, sex'center, age, proWlon of residential type in the last 35 yrs (REUP) and educational level (EDUC) S4f hlode( Frtclude sex, center, sox'center, age and duratron of exposure to Ost A aSents (OCLAY) (5) Model Include sox, center, sex'ccnter, age and frequency consumption of vegetables (VEGE) Risk estimates - Occasional smoking

rr_s. I vv Childhood 0-18 yrs, Smoking parent years MEN ONLY Level of exposure Cases Controls ORH1 95% CI I OR 2 95 b CI OR(3) 95% Cl I OR(4 95X CI OR(5 95X CI ( N7:. ~ GlUS~18 116 365 1.00 1.00 1.00 1.00 1.00 1D<C1US<31 21 120 0•58 ( 0-32- 1.06) 0.65 ( 0.34- 1.24) 0.66 ( 0.29- 1.49) 0.57 ( 0.31. 1.05) 0.48 ( 0.22- 1.02) 3t<cws l 3 37! 0.23 ( 0-06- 0.85) 0.35 ( 0.10- 1.26) 0.20 ( 0.02- 1.76) 0.28 ( 0.08- 1.00) 0.45 ( 0.12- 1.77) Exclud.d/rrond 1 91 0.01 0.01 € 0.01 0.01 0.01 WOMEN ONLY NE.r C1U$<1D 99<G1US<31 31<C1US 364 660 1.00 1.00 1.00 1.00 1.00 I 120 267 0.91 ( 0.69- 1.20) 0.94 ( 0.70- 1.26) 0.96 ( 0.68- 1.36) 0.94 ( 0.71• 1.25) 0.92 ( 0.66- 1.27) l 17 68 0.67 ( 0.38- 1.20) 0.57 ( 0.30- 1.06) 0.47 ( 0.22- 1.01) 0.66 ( 0.36. 1.19) 0.60 ( 0.27- 1.36 ) Erclud.d/rrond 8 16 0.18 0.19 0.18 0.17 0.18 POPULA7ION BASED STUDIES NE., C1US<1fl 19<C1US<31 31<C1US I fxcludid/Trond HOSPITAL BASED STUDIES NE.r C1US<.1G 1D<C1US<31 31<C1US &cl uded/Trend Wi7HOtYP OCCASIONAL SMOI<ERS 300 60 12 I 668 201 62 181 1,00 1•00 ( 0.74 ( 0.53 0•70- 0.37- 1.43) 1•48) 1.00 1.07 ( 0.81 ( 0.74- 1.55) 0.40- 1•63) 1.00 1.18 ( 0.68 ( 0.75- 1.85) 0.28- i•66) 1.00 1.04 ( 0.71 ( 0.72- 0.35- 1•50) 1-46) 1.00 1•05 ( 1.42 ( 0.67- 0.51- 1.64) 3.99) 242! 1,00 1.00 1•00 ( 1•00 1.00 178~ 0,73 ( 0.51. 1.03) 0.68 ( 0.46- 1•02)~ 0•74 ( 0.47- 1•18)' 0.73 ( 0.52- 1.05) 0.67 ( 0.45- 1.01) 25 0•38 ( 0.15- 0.92) 0.22 ( 0.06- 0.77) 0.24 ( 0.05- 1.11)' 0.41 ( 0.17- 1.01) 0.27 ( 0.08- 0.94) 0•01 ~ 0.01 1 0.01 I 0.01 0.01 NE.~ C1U5<•19 360 750 1.00 1.00 1•00 1.00 1•00 tD<C1us<.31 105 266 1,02 ( 0•75• 1.37) 1.04 ( 0.75- 1•43)1 1.08 r, 0.75- 1•56) 1.04 ( 0.77- 1.41) 1.01 ( 0.70- 1.46) 31<C1US 15 71 0.70 ( 0.38• i.30) 0.67 ( 0.35- 1.28) ~ 0.55 ( 0.25• 1•20) 0.68 ( 0.36- 1.30) 0.68 ( 0.28- 1.67 ) s"xcludad/rrond~ 6 ! '71 0.47 I 0.46 0.50 ~ 0.46 0.52 AGE<55YEARS NE., C1U$<18 1D<C1US<31 31<C1U5 1 228 1.00 1.00 1.00 1.00 I 1.00 98 0.86 ( 0,53• 1.41) 1.00 ( 0.58- 1.71) 1.21 ( 0.64- 2.29) 0.91 ( 0.55- i.50) 0.72 ( 0.41- i.27) 7i 31 0.58 ( 0.22- 1.49) 0.79 ( 0.28- 2.28) 0.32 ( 0.06• 1,76) I 0.53 ( 0.19- 1.48) 0.82 ( 0.22- 3.10)y ` fxcluded/Trend 41 0.24 0.24 1 ! 0.28 0.21 I 0.23 IE AGE 55-84 YEARS NE.r C1U5<19 19<C1US<r31 31<C1US 164 386 1.00 1.00 1.00 I 1.00 1.00 119~ 0.78 ( 0.49• 1.25) 0.73 ( 0.45- 1.20) 0.82 ( 0.46• 1.48) 0.82 ( 0.51- 1•32) 0,68 ( 0.38- 1.23)1 34 I 0.44 f, 0.16- 1.20) 0.37 ( 0.12- 1.09) 0.34 ( 0.10• 1.19) 0.45 ( 0.16- 1.25) 0.26 ( 0.06- 1.17) fxcluded/Trond 4~ 13J 0,07 0.08 0.06 0.08 0.0 7 ~ I AGE 65+~ YEARS NE., C1U 5< 19 197 411 1,00 1.00 1.00 1.00 1•00 19<C1U5<31 66 170 0.89 ( 0•61- 1.31) 0.97 ( 0.65- 1.45) 0.92 ( 0.56- 1•51) 0.87 ( 0.59- 1•28) 1-02 ( 0.66- t.58) 31<C1US 8 40 0.58 ( 0.25- 1.36) 0.46 ( 0.18- 1,18) 0.55 ( 0-19- 1•56) I ~ 0.59 ( 0.25- 1.37) 0.74 ( 0.26- 2.15) fxcluded/Trand 4 81 0.22 0.22 j 0.23 I ~ 0•18 ~ 0.24 HISTOLOGICALLY CONFIRMED DIAGNO SIS NE., C1US<19 463 1025 1.00 1.00 1 1.00 1.00 1.00 1D<C1US<.31 136 387 0,85 ( 0.66- 1.09) 0.89 { 0.68- 1,16) 0.91 ( 0.66- 1.25) 0.87 ( 0-67- 1,12) 0.82 ( 0.61- 1.10) 31<C1US 19 105 0.52 ( 0.30• 0.89) 0.50 ( 0.28- ~ 0.90) 0•40 ( 0•19- 0.83) 0.53 ( 0.30- 0.91) 0.52 ( 0.25- 1.07) EXCluded/Trendl 3 25 0.01 0.01 0.01 0.01 0.01 SOUAMOUS CELL CARCINOMA NE,s C1US<19 85 1025 1.00 1.00 1.00 1.00 1.00 19<C1U5<31 20 387 0.73 ( 0.42- 1.26) 0.63 ( 0.33- 1.19) 0.88 ( 0.43- 1.79) f 0.74 ( 0.42- 1.29)f 0.62 ( 0.30- 1.27) 31<C1US 3 105 0.4( ( 0.13• 1.55) 0.40 ( 0•09- 1.71) 0.55 ( 0.12- 2.48)I 0.33 ( 0.08- 1.45) 0.00 ( 0.00-99.99) fxcluded/rrlnd I 25 0.17 ! 0.11 0.10 ~ 0• 10 ~ 0.11 SMALL CELL CARCINOMA NE,, C1US<18 59 1025 1.00 1.00 1.00 1.00 1.00 19<C1US<r31 ~ 9 387 0.84 ( 0.38- 1•86) 0.86 ( 0.38- 1.97) 0.87 ( 0.35- 2.16) 0.89 ( 0.40- 2.01) 0.87 ( 0.37- 2.06) 31<C1US 11~ 1 105 0•55 ( 0.07- 4.32) 0.54 ( 0.07- 4.25) 0.00 ( 0.00-99.99) 0.63 ( 0.08- 5.01) 0.00 ( 0.00-99•99) fxclud~d/rrend ~ 1 25 0.51 0.46 ~ 0.46 ~ 0.52 0.50 ADENOCARCINOMA NE.~ C1US<19 ! 19<C1US<.31 ~ 31<C1US 243 1025 1.00 1.00 1.00 1.00 1.00 74 387 0.83 ( 0.60- 1.14) 0.89 ( 0.63• 1.26) 0.87 ( 0.58- 1.33)1 0.83 ( 0.60- 1.15) 0.78 ( 0.54- 1.14) 11 105 0.57 ( 0.29- 1.14) 0.59 ( 0.28- 9-<^S) 0.54 { 0.22- 1.34) 0.61 ( 0.31- t•21) 0.70 ( 0.30- 1.64) fxcluded/Trendl 5 25 0.06 ~ 0.07 0.08 i 0.05 I 0•07 OTHER NE,, C1US<1fl 75 1025 1•00 1.00 1. 00 7. 00 1.00 19<C1US<31 33 387 t•17 ( 0.66• 2.09) 1.07 (. 0.67- 1.71)~ 1.22 ( 0.75- Z 01)~ 7. 12 ( 0.70- 1.79) 1.20 ( 0,70- 2.06) 31<C1US 4 105 0.19 ( 0.03- t.a6) 0.50 ( 0.17- 1.45) 0.44 ( 0.13- 1•50) O.Sa ( 0.19- 1.58) 0.82 ( 0.23- 2.88) fxcluded/Trand ( i 2 25 0.44 0.44 0.44 0.47 0.45 >75SG OF LIFESPAN IN RURAL AREA OR INTERMEDIATE CI71ES NE.r C1US<tfl 215 421 1.00 1.00 I 1.00 0.96) 0.62 ( 0.34- 1.14) 19<C1US<.31 35 115 0.60 ( 0.37- 0.96) 0.60 ( 0.37-0.18 ( 0.04. 0.80) 0.18 ( 0.04- 0.80) 0.00 ( 0.00-99.99) 31<C1US 2 34 1.00 1.00 0.62 ( 0.38- 1.00) 0.60 ( 0.35- 1.01) ~ 0.19 { 0.04- 0.83) 0.12 { 0.02- 0.93) fxcluded/Trend! ' 4 5 0.00 0.00 0.00 0-00 ~ 0.00 >73')C OF LIFESPAN IN URBAN AREA C1US<19 162 425 NE., 19<C1US<r31 69 211 31<C1US 9 60 1.00 1.00 1.00 1.00 1.00 1,00 ( 0.69- 1.44) 1.00 ( 0.69- i.44)1 1.05 ( 0.69- 5.60) 1.04 ( 0.71- 1.50) 0.96 ( 0.62- 1.50) 0.54 ( 0.25- 1.18) I 0.54 ( 0.25• i.18)~ 0.54 ( 0.21- 1.38) 0.50 ( 0.22- 1.13) 0.59 ( 0.20- 1.73) fxcludld/Trendl 41 151 0.27 ~ 0.27 i 0.27 ~ 0.25 0.27 (1) Model kidude sax, c®nter, sex'center and age (2) Model lrloludo ssx, oonter, sex'eonter, age and proportion of resldential typa in the last 35 yrs (REUP) (3) Model lndudc sox, contor, sex'conter, age, proportion of residential type in the last 35 yrs (REUP) and educational level (EDUC) (4) Mode! include sex, center, sex•c®rtter, age and duration of exposure to list A agents (OCLAY) (5J Mad¢(irtctuCe sex, can(er, sax'aanter, ege anti frequency cOnsumpitwl of vegeta0les (VEGE) 2063593322 Risk estimates - Childhood 0-18 years

CSCU Occasional smoking, Cumulative exposure (packs/lifetime) ALLCENTERS i Total Exqosed Unexposed ( Excluded Min P10 01 ~ Median 03 ! P90 1Max . ~ Mean € Std Mtui Ca'Cf 138 39` 95 4 0.05 0.05 0.25 ((( 2.40 5.40 9.001 18.00 3.82 4.43 Control: 517 1431 350 24 0.05 0.13 0.50 ~ 2.00 6.90~ 13.001 20.00 4.45 E 5.32 All 672 18211 445 45 0.05 0.10 0.50 2.22 6.50~ 13.00 20.00 4.31 5.14 WOnlen Ci50f 486 93 378 15 0.03 0.05 0.15 0.75 3.00 9.00 18.25 2.90 4.77 Controll 8B5 179 682 24 0.03 0.05 0.15 1.00 1 4.00 i1.40 19.20 3.11 4.63 A11 1520 272 1060 188 0.03 0.05 0.15. 1.00 3.60 11.20 19.20 3.04 4.67 A8 C35es 650 132 473 45 0.03 0.05 0.15 1.00 3.75 9.00 18.25 3.17 4.671 Controlf 1642 322 1032 988 0.03 0.05 0.25 1.20 5.20 12.10 20.00 3.71 4.99 !U1 2192 454 1505 233 0.03 0.05 0.25 1.00 5.20 12.00 20.00 3.55 4.90~ MOn Ca303 89 14 74 1 0.15 0.50 2.50 4.50 7.80 13.00~ 18.00 5.78 5.02 Controls 456 109 326 21 0.05 0.15 0.50 2.50 6.90 13.00 20.00 4.70 5.39 All 582 123 400 39 0.05 0.15 0.75 2.50 7.80 13.00 20.001 4.82 5.34 YYom6n Cases 363 57 315 11 0.03 0.10 0.15 9.00 3.60 13.00 18.25 3.37 4.91 ~ Controls 742 127 594 21 0.03 0.10 0.30 1.20 5.40 13.00 19.20 3.68 6.04 A11 1274 184 909 181 0.03 0.10 0.25 1.00 5.20 13.00 19.20 3.58 4.99 AII Casof 498 71 389 38 0.03 0.10 0.30 1.55 5.40 1•3.00 18.251 3.85 4.99 CMlrolf 1330 236 920 182 0.03 0.10 0.50 `:.50 5.80 1300 . ~ 20.00 i 4.15 5.22 AH 1836 307 1309 220 0.03 0.101 0.50 1.50 5.60 13 .00 I 20.00 4.08 5.16 ALL CENTERS WITH DIETARY DATA MOn Casss 101 27 73 1 0.05 0.05 0.15 1.80 4.50 13.00 18.00 4.05 5.10 Controls 292 81 196 15 0.05 0.15 ~ 0.50 1.80 5.30~ 13.00 20.00 4.18 5.13 All 410 108 269 33 0.05 0.10 0.50 1.80 5.75~ 13.00 20.00 4.15 5.10 Wommn Oasss 382 77 294 11 0.03 0.05 0.13 0.60 2.60 7.80t 18.00 2.42 3.93 Controls 624 142 463 19 0.03 0.05 0.10I 0.95 3.10 10.20~ 19.20 2.73 4.22 Atl 1155 219 757 179 0.03 0.05 0.10 0.60 3.00 9.00 19.20 2.62 4.11 AII CasOf 509 104 367 38 0.03 0.05 0.14 0.95 3.68 8.40 18.00 2.84 4.30 Controls 10561 223 6591 174 0.03 0.05 0.25 1.00 5.00 11.20 20.00 3.26 4.62 All 1565 327 1026 212 0.03 0.05 0.15 1.00 4.80 10.40 20.00 3.12 4.51 FRAN Man Casos 14 8 8 0 2.50 2.50 7.80 8.40 13.00 18.00 18.00 9.68 5.28 ! Controls 23 16 7 0 0.25 0.50 1.50 3.45 12.50 15.00 17.55 6.31 5.94 AIt 37 22 15 0 0.25 0.50 2.50 6.50 13.00 15.00 18.00 7.23 5.85 :om6n Cases ®3 27I 36 0 0.05 0.10 0.40 1.00 5.20 13.00' 18.00 3.65 5.00 Controlf All 128 191 62If 89 66 102 0 0 0.05 0.05 0.10 0.10 0.50 0.50 1.00 1.00 5.00 5.20 12.00IIIIII/ 19.20 13.00 19.20 3.35 3.44 4.73 4.79 .+1 O.afOf Controlf Atl '7 151 228 33 78 111 44 73 117 " 0 0 0 0.05 0.05 0.05 0.15 0.15 0.15 0.50 0.50 0.50 2.40 1.35 2.00 7.80 5.60! 6.501 13.00 18.00 13.00 19.20 13.001 19.20 4.74 3.96 4.19 5.50~ 5.11 5.21 .: ERMANY 1 an Cases ~~18 3t 15 0 0.50 0.50 0.50 2.60~ 5.40 5.40 5.40 2.83 2.46 ! 129 Controls 26 97 6 0.08 0.15 0.75 1.50 4.80 10.20 19.80 3.54 4.68 All P 147 29 112 6 0.08 0.15 0.75 1.80 4.80 10.20 19.80 3.47 4.48 WOn10n Cases 3e 9 48 1 0.03t 0.03 0.50 1.00 3.60 7.80 7.80 2.62 2.961 Controls ~ 100 i5 84 1 0.03 0.03 0.50 1.20 7.80 12.00 15.60~ 3.86 5.20 All 158 24 1 132 2 0.03 0.03 0.50 1.10 5.45 11.40 15.60 3.39 4.46 All Casaf 76 12 63 1 , 0.03 0.15 0.50 1.80 4.50 7.00 7.80 2.67 2.73 Controls 229 41 181 7 E 1 0.03 0.13 0.50 9.20 4.80 11.40 19.80 3.66 4.81 AII 305 53 244 8 0.03 0.13 0.50 1.20 4.80 10.20 19.80, 3.43 4.42 GERMANY 2 Mon Gsef 29 28 0 5.00 5.00 5.00 5.00 5.001 5.00 5.00 5.00 . Controis 85 8 56 1 0.05~ 0.05 - 0.85 3.38 5,10~ 16.50 16.50 4.40~ 5.33 A11 94 9 84 0.05 0.05 1.20 5.00 5.00 16.50 16.50 4.47 4.99 Woman Cases 113 4 109 0 0.08 0.08 0.10 0.131 6.56 13.00 13.00 3.33 6.45 t Controls 98~ 7I 91 0 0.08 0.08 0.30 1.80~ 5.40 1 0.40E 10.40 3.27 3.66 A11 211 1 ~ 00 0 0.08 0.08 0.13 1.30 5.40 10.40 13.00 3.29 4.53 All CasOs 142 5 137 0 0.08 0.08 0.13 0.13 5.00 13.00 13.00 3.671 5.63 ConUols 163 15 147 1 0.05 0.08 0.50 I 1.80 5.20 10.401 16.50 3.87 ~ 4.51 All 305 20 284 1 0.05 0.08 0.21 1.78 5.10 11.70 16.50 3.82 4.65 3ERMANY3 dan Cases 10 0 101 0 bb ~ Controls 14 1 11 1 2 ?.00 1.00~ 1.00 1.00 1.00 1.00 1.00 1.00 . € All 24 1 11 21 2 1.00 1.00 1.001 1.00 1.00 1.00 1.00 1.00 WOman Cases ~1 1 20 0 9.00 9.00 9.00 9.00~ 9.00 9.00 9.001 9.00 . Conlrois 38 0 38 0 ! Afl 59 1 58 0 9.00 9.00 9.00 9.00~ 9.00 9.00 9.001 9.00. Ali CasCf 31 1 30 0 9.00 9.00 9.00~ 9.00 9.00 9.00 9.00 9.00 Controls 52 1 49 2 1.00 1 1.00 1.00 `:.00 1.00 1 ~ 1.00 1.00 1.00 All 83 2 79 2 1.00 1.00 1.00 5.00 9.00 9.00 9.00 5.00 5.66 tTALY I Men Cascl Controls All 8 3 5 0 0.15 0.15 0.15 1.55 4.00 4.00 4.00 1.90 1.95 103 37 62 4 0.05 0.10 0.25 1.50 6.90 14.00 20.00 4.32 5.47 111 40 67 4 0.05 0.10 0.25 1.53 6.13 13.50 20.00, 4.14 5.32 Womon Cases 32 9 23 0 0.10 0.10 0.15 0.50 1.00 3.00 3.00 0.93 0.98 Controls 118 23 93 2 0.05 0.10 0.25 0.75 7.50 15.00 18.25~ 4.29( 5.91 All 150 32 116 2 0.05 0.10 0.251 0.63 3.50 13.00 18.25 3.34 5.23 All Cases 40 12 28 0 0.10 0.15 0.15 0.75 1.78! 3.00t 4.00 1.18 1.26 Controls 221 60 155 6 0.05~ 0.10 0.25 1.40 7.351 14.50{{{ ~ 20.00 4.31 5.59( AN 2611 72 183 6 0.05 0.10 0.25 1.00 5.28~ 13.00 20.00 3.78 { 5.26I ~0635`~330]. Descriptive stetistics - Occasional smoking

-[_C'9TP Childhood 0-18 yrs, exposure to different tobacco products ALL CENTERS taval o9 expcsaro `~ - Cas es ) Contr ols OR{l) 95% c1 Non eXpOsen 252 496 1.00 Only cigarette 231 577 0.79 ( 0.62- 1.00) Never Qigarette 92 205 0 79 ( 0 58- 1 09) Cigarette + other ~f 42 140 . 0.58 ( . 0.39- . 0.87) Excluded/Trend 93 124 ALL CENTERS W1TH EDUCATIONA_L LEVEL AND TYPE OF RESIDENCE OR(2) 95% CI ( OR(3) 95% Cl ( OR(4) 95% C( ( G'R(5) 95% Cf ( 1.00 1•00 ( 1•00 1.00 1 0.82 ( 0.63- 1.07) 0.85 ( 0.62- 1.16) 0.88 ( 0.63- 1,22) 0.80 ( 0.55- 1.17) 0.64 ( 0.42- 0.96) 0.57 ( 0.35- 0.92) 0.80 ( 0.63- 1.02)/ 0.75 ( 0.57- 1.00) 0.81 ( 0.59- 1.12)lif 0.81 ( 0.58- 1.14) 0.58 ( 0.39- 0.87) 0.55 ( 0.35- 0.87) Non exposed 149 350 1.00 1.00 1.00 1•00 1•00 Only cigarette 153 419 0•86 ( 0.63- 1.17) 0.86 ( 0.63- 1,17) 0.85 ( 0.62- 1.16) 0.88 ( 0.64- 1.20) 0.84 ( 0.59- 1.17) Never cigaretta 70 165 0.79 ( 0.54- 1.14) 0.79 ( 0.54- 1•15) 0.80 ( 0.55- 1.17) 0.80 ( 0.55- 1.17) 0.81 ( 0.55- 1.21) Cigaretto + other 30 107 0.59 ( 0.36• 0.96) 0.59 ( 0.37- 0.96)1 0.57 ( 0.35- 0.92) 0.58 ( 0.36- 0.96) 0.53 ( 0.31- 0.94) €xcludod/Tivndl 96 1 297 ALL CENTERS WfTH DIETARY DATA ( Non @xposotl 169 320 1.00 1.00 1•00 1.00 1.00 Only cigarotte 165 359 0.75 ( 0.57- 1.00) 0.77 { 0.57- 1.04) 0.83 ( 0.59- 1.17) 0•75 ( 0.56- 1.00) 0.75 ( 0.57- 1.00) Never cigarette 86 161 0.81 ( 0.57- 1.13) 0.88 ( 0.62- 1.25) 0.84 ( 0.56- 1.25) 0.83 ( 0.59- 1.17) 0.81 ( 0.58- 1.14) Cigaratto + other 33 87 0.55 ( 0.34• 0.86) 0.58 ( 0.37- 0.93) 0.52 ( 0.29- 0.91)1 0.56 ( 0.35- 0.89) 0.55 ( 0.35- 0.87) EXcluded/Trend .76 1291 ( € € FRANCE Non OXpOSan Only cigarette Never cigarette Cigar@tto + other cXCludtd/Trtnd GERMANY1 Non exposed Only cigarette Never cigarette Cigarette + other Bxc1 udtd/Trend 32 37 1.00 1.00 1•00 1.00 1.00 35 91 0•45 ( 0.24- 0.83) 0.64 ( 0•31- 1.30) 0.97 ( 0•37• 2.54) 0.43 { 0•23- 0.89) 0.45 ( 0.24- 0.83) 6 11 0.66 ( 0.22- 2.02) 1.69 ( 0.49- 5•90) 3.35 ( 0.65-17.26) 0.65 ( 0.21- 1.98) 0.68 ( 0.22- 2.09) 3 12 0.31 ( 0•08- 1.21) 0.44 ( 0.11- 1•78) 1.14 ( 0.18- 7.26) 0.30 (•0•08• 1.19) 0.31 ( 0•08- 1.24) ; 0 ~ ~ 29 74 1.00 1.00 t.o0 1.00 1.00 18 58 0.68 ( 0•32• 1.44) 0.68 ( 0.29- 1.60) ) 0.69 ( 0.29• 1.64) 0.78 ( 0.36- 1.68) 0.69 ( 0.32• 1.51) 25 68 0.68 ( 0.34- 1.35) 0.75 ( 0.36- 1.57 0.75 ( 0.35- 1.62) 0.71 ( 0.35- 1.42) 0.72 { 0.36- 1-44) f 2 26 0.17 { 0.04- 0.80) 0.20 ( 0•04• 0.97) 0.21 ( 0.04- 1•04)~ 0.18 ( 0.04- 0.85) 0.21 ( 0.04- 0.98) I 2 3 GERMANY2 Non exposed 62 63 1.00 1.00 1•00 1.00 ! 1.00 Only cigarette 1 35 37 1.00 ( 0.55- 1•84) 1.01 ( 0.55- 1.87) 1.02 ( 0.54- 1-90) 1.00 ( 0.54- 1.83) 0.99 ( 0•54- 1•82) Navor cigarette t 26 41 0.64 ( 0.34- 1.20) 0.66 (, 0.35- 1.24) 0.63 ( 0.33- 1.20) 0.64 ( 0.34- 1.19) 0.65 ( ~ 0.35- 1.22) Cigarette + other ~ 15 20 0.71 ( 0.33- 1•56)~ 0.73 ( 0.33- 1.60) 0.68 ( 0.30- 1•51) 0.71 ( 0.33- 1.55) 0.73 { 0.33- 1.59) Excluded/Trtndlll 4 2 € Non expoa@n 15 18 .oo 1.00 1.00 I 1.00 1.00 Only cigaretta 5 14 4i ( 0.11- 1.60) 0.41 ( 0.10- 1.60) 0.39 ( 0.09- 1.65) 0.52 ( 0.13- 2.10} 0.36 ( 0.08- 1.49) cigaratto 9 16 76 ( [ 0.22- 2.66) 0.76 ( 0.21- 2.67) 0.68 ( 0.18- 2.52)~ 0.99 ( 0.27- 3.62) 0.59 ( 0.16- 2.20)1 Cigarotte + other 1 3 0, 33 ( 0.03• 3,91) 0.32 ( 0.03- 3.87) 0.38 ( 0.03- 5.33)) 0.38 ( 0.03- 4.54) 0.37 ( 0.03- 4.48)~ P Excludtd/Trend > ; 666 ITALY I @XpOa@q {S ~ Non Only cigarette NtVOr cigarette Cigarette + other €xc1udad/Trend~ 11 49 1.00 1.00 1.00 1.00 ~ 18 103 0,59 ( 0,24- 1.43) 0.81 ( 0.31- 2•16) 0.86 ( 0.32- 2.33) 0.68 ( 0.27- 1.72)1 4 24 0.75 ( 0,20- 2.77) 0.96 ( 0.25- 3.78) 0.70 ( 0.16- 3.10) 0.57 ( 0.13- 2.42) 7 35 0.63 ( 0,21- 1.92) 0.90 ( 0.28- 2.96) 0.93 ( 0.28- 3.14) 0.56 ( 0.17- 1.82) ~ 2 10 , ITALY 2 expos@q Non Only cigarette Ncw r cigarette 6 77 1.00 1.00 1.00 1.00 10 64 2.28 ( 0.73- 7.06) 3.96 ( 1.04-15.10) 2.29 { 0.47•11.11) 2.46 ( 0.78- 7.75) 1 17 0.92 ( 0.10- 8.77) 1.79 ( o.1s-2o•ao) 0.00 ( 0.00-99.99) 1.02 ( 0.10- 9.96) Cigarette + other 2 13 2.89 ( 0•46-18•33) 3.64 ( 0.33-39.97) 1.15 ( 0.08-16.14) 3.43 ( 0.52-22.54) €xc2uded/Trendi 0 2 ITALY 3 Non @xpos@c ~ 7 19 1-00 1.00 ) 1.00 1.00 1.00 Only Ciparett! 4 27 0.35 ( 0.08- 1•50) ~ 0•29 ( 0.06- 1.46) 0.24 ( 0.04- 1•45) 0.29 ( 0.06• 1.37) 0.38 ( 0.07- 2.01) Never cigarltt! 3 3 1.52 ( 0•21-11•00) 1.10 ( 0.14- 8.52) 0•59 (, 0.07- 5•07) 1.59 ( 0•21-11•90) 1.09 ( 0.12- 9.59) Cigarette + Other 2 1 3.25 ( 0,21•50.54) 2,42 ( 0•15-39•34) 99•99 ( 0•00•99.99) 1.78 { 0.08•38.60) 99.99 { 0.00-99.99) Excludtd/Trendl 0 0 ~ ( PORTUGALI YOn OXpcatO 24 15 1,00 ' I 1.00 Only cigarette 1 22 21 0,66 ( 0.26- 1,68)I E€ 0.68 ( 0•26• 1.77) ~ ' Never cigarette 0 99.99 ( 0•00-99•99)fi ~ 99.99 ( 0.00•99.99) 6 5xcludtd/Tr.ndl 2 3 PORTUGAL3 Non expos00 17 26 1.00 1.00 ( 1.00 Only cigarette 16 24 1.05 ( 0.42- 2.62) 0.78 ( 0.28- 2•17)I 0.99 ( 0.39- 2.53) Never Cigarette 0 2 0.00 ( 0•00-99•99) 0.00 ( 0•00-99.99) 0.00 ( 0•00•99.99) Cigarette + othor 0 1 0.00 ( 0•00•99•99) 0.00 ( 0•00-99•99)i ( 0.00 ( 0.00•99•99) Excluded/Trend 0 ~ 0~ € ! ~ i SPAIN Non e xpoaen 13 32 1,00 1.00 1•00 1.00 1• 00 Only ciparette 55 1051 1.26 ( 0•60- 2.63) 1.05 ( 0•49• 2.27) 1•38 ( 0.59- 3.20) 1.21 ( 0•58- 2.54) 1•26 ( 0.60- 2.67) r cipa n tt! Nevo ' 6 0.45 ( 0.05- 4.15) 0.35 ( 0.04- 3.25) 0.48 ( 0.05- 4.73) 0.56 ( 0.06- 5•37) 0.43 ( 0.05- 4.09) Cigarott@ + other 0 12 0.00 ( 0.00-99.99) 0.00 ( 0.00-99.99) 0.00 ( 0•00•99•99) 0.00 ( 0•00•99•99) 0.00 ( 0•00-99•99) uded/Trend €xc1 2 4 i ~ SWEDEN Non exposen 29 45 1.00 1.00 00 1. 1.00 ) Only cigarette ~ 15 33 0.73 ( 0.33- 1.61) 0.68 { 0.31- 1.52) ( = 0.74 ! 0.33- 1.63 0.69 0.31- i.53 )1 ( ) Never Cigerette 16 17 1.35 ( 0.58- 3.18) 1.33 ( 0.56- 3.14) 1.30 ~ ( 0.55- 3.07) 1.22 0.51- 2.90) I { Cigarotte + other 10 17 0.91 ( 0.36- 2.31) 0.84 ( 0.33- 2.17) 0.80 ' ( ~ 0.31- 2.10)I 0.94 0.37- 2.40) ( Excluded/Trtnd1 0 0 Ili EEE( UNITED KINGDOM Non expoaeq :.xcluded/Trend~ 191 (1) Model k)akxlo sex, conter, sex'oantor and age 41 99 1.00 1.00 (2) Model inckx4e sex, center, sox'center, age and proportion of residential type in the last 35 yrs (REUP) ;(3) Model wsctude sex, cen(or, sex'center, age, proportion of residential type in the tast 35 yrs (REUP) and educational level (EDUC) (4) N(oQe( kletuCa Sox, cCnfer, ScX-Gen(er, age end durafion of exposare to I'rst A agents (OCLAY) (5) Model iriclude sex, contor, sox'contor, age and frequency consumption of vegetables (VEGE) 1 7 i i 1.00 1•00 ---~ . ---- - -- 20b3593313 Risk estimates - Childhood 0-18 years

®SCU Jccasional smoking, Cumulative exposure (packs/lifetime) tTALY 2 Total Expo9ed UnexooSad l Excluded I Mfn P10 ~ 01 Median 03 P90 Max Mean ( $td Men Cases 3 0 3 0 Co(1tro/l 97 17 78 2 0.15 0.30 1.25 3.90 7.80 18.00 18.25 5.61 5.90 All 100 17 81 2 0.15 0.30 1.251 3.90 7.80 18.00 18.25 5.61 i 5.90 WOmen CasQ1 16 4 12 0 0.10 0.10 1.40 9.15 16.93 18.25 18.25 9.16 9.09 Conttol3 76 8 68 0 0.05 0.05 0.20 2.05 12.30 18.25~ 18.25 5.93 7.42 A!I 92 12 80 0 0.05. 0.10 0.20 2.65 15.60 18.25~ 18.25 7.00 7.76 AU CiSe1 1 9 4 15 0 0.10 0.10 1.40 9.15 ~ 16.93 18.25 _ 18.25 9.16' 9.09 Conlrols 31 7 1 25 146 2 0.051 0.15 0.75 3.00 9.00 18.00 18.25 5.71 6.27 All 192 29 161. 2 0.05 0.15 0.75 3.00 10.00 18.25 18.25 , 6.19 6.64 ITALY 3 Men Casat 1 9 0 Controls 12 3 9 0 5.20 5.20 5.201 9.80 13.00 13.00~ 13.00 9.33 3.92 AM 13 3 f 1 0 0 5.20 5.20 5.201 9.80 13.00 13.00 13.00 9.33 3.92 fWort10(1 CBsOf 1B 1 14 0 0.30 0.30 1 0.30 0.30 0.30 0.30 0.30 0.30 ` Controls 38 1 37 0 5.20 5.20 5.20 5.20 5.20 5.20 5.20 5.20 .$` ? AN 53 2 51 0 0.30 0.30 0.30 2.75 5.20 5.20 5.20 2.751 3.461 AIl C6sef 16 1 15 0 0.30 0.30 0.30 0.30 0.30 -0.30 0.30 0.30 Controls s0 4 48 0 5.20 5.20 5.20 7.50 11.40 13.00 13.00 8.30 3.81 All 66 5 61 0 0.30 0.30 5.20 5.20 9.801 13.00 93.00 6.70 4.87 PORTUGALI Man CQSOS 16 2 13 1 5.20 5.20 5.20 6.20 7.20 7.20 7.20 6.20 1.41 Controls 8 3 1 4 1 2.40 2.40 2.40 7.20 15.60 ~ 15.60 ~ 15.60 8.40 6.68 All 24 s 17 2 2.40 2.40 5.20 7.20 7.20 15.60f 15.60 7.52 4.93 Women Ciset 33 2 29 2 18.00 18.00 18.00 18.00 18.00 18.00 18.00 18.00 0.00 Controls 31 1 28 2 7.20 7.20 7.20 7.20 7.20 7.20 ~ 7.20 7.20 All 64 3 L7 4 7.20 7.20 7.20 18.00 18.00 18.00 18.00 111 14.40 6.24 AA Casei 49 4 42 3 5.20 5.20 6.20 12.60 18.00 18.001 18.00 12.10 6.86 Controls 39 4 32 31 2.40 2.40 4.80 7.20~ 11.40 95.60 15.60 8.10 5.49 AJ1 88 8 74 6 2.40 2.40 ^.20 >'.20i 96.80 18.00 18.00 10.10 6.14 PORTUGAL2 '.`Qn CeSQ1 10 7 1 21 0.101 0.10 2.05 2.40 3.75 7.80 7.80 3.07 2.37 Controls 17 5 10 2 0.05/ 0.05 0.20 1.00 3.60 12.10 12.10 3.39 5.07 Afl z7 12 '1 4 0.05 0.10 0.60 2.40 3.68 7.80 '.2.10 3.20 3.53 :9mQn C81e= 23 1 20 2.40 2 2.40 2.40 2.40 2.40 2.40 2.401 2.40 .~ ConUoii 36 5~ 30 ~ 1.00 1 1.00 2.40 2.40 4.00 1 7.20 7.20~ 3.40 2.37~ AII 59 6 50 f 3 1.00 1.00 2.401 2.40~ 4.00 7.20 7.20 3.23 2.16 ... ClSQL 33 8 21 4! 0.10 0.10 2.22 2.40 3.38 7.80 7.80 2.99 2.20 Controls 53) 10 40 31 0.05 0.13 1.00 2.40 4.00 9.65I 12.10 3.40 3.73 All 86 18 61 7 0.05 0.10 1.00 2.40 3.75 7.80 12.10 3.21 3.07 SPAIN Mon CQSOf 6 1~4 1 3.601 3.60 3.60 3.60 3.60 3.60 3.60 3.60 Controls 13 1 6 6 0.13~ 0.13 0.13 0.13 0.13 0.13 0.13 0.13 All 19 2 10 7 0.13~ 0.13 0.13 1.86 3.60 3.60 3.60 1.86 2.46 Women Castt 65 2 53 10 0.05 0.05 0.05 1.28 2.50 2.50 2.50 1.28 1.73 ConU01t 146 11 117 18 0.03 0.05 0.08 0.90 2.25 9.00 11.20 2.46 3.89 AII 211 13 170 28 0.03 0.05 0.08 0.90 2.25 9.00 11.20 2.28~ 3.61 AII CLSQD 71 3 57 11 0.05 0.05 0.05 2.50'2 3.60 3.60 3.0"0 2.05 1.82 Controls 169 12 /23 24 0.03 0.05 0.09 0.601 2.13 9.00 11.20 23.77 ~ AiI 230 95 180 35 0.03 0.05 0.08 0.90~ 2.50 i 9.00 11.20 c^.23 3.41 SWEDEN Man C7tet 23 16 71 0 0.05 0.05 0.08 0.25 i.531 6.50 16.30 2.13 4.24 Conlro;t 36 26 10 0 0.05 0.05 0.30 0.68 5.001 10.00 20.00 3.14 4.82 All 59 42 17 0 0.05 0.05 0.15I 0.55 3.00 9.60 20.00 2.764.58 Womon CateS 47 33 14 0 0.05 0.05 0.10 0.40 1.00 3.75 12.60 1.19 2.37 € Controls 76 46 30 0 0.05 0.05 0.05i 0.13 1.001 5.20 12.50 1.43 3.01 E All 123 79 44 0 0.05 0.05 0.05f 0.25 1.00 4.75 12.60 1.331 2.75 AH Caet 70 49 21 0 0.05 0.05 0.10 0.25 1.20 5.00 16.30 1.50 3.09 Controls 112 72 40 0 0.05 0.05 0.05 0.50 1.38 7.25 20.00 2.05 3.82 All 182 121 61 0 0.05 0.05 0.05 0.50 1.20 5.20 20.00 1.83 5.54 UNITED KINGDOM MQn Casot Controls All tNoman CasQ1 Convois All 3 0 0 3 ! 14 0 0 1 4 ~ 171 0 0 17 11 ~ ~ 23 0 0 23 126 0 0 '•26 149 0 0 149 ~ All CSSQt ConUab 26 140 0 0 0 0 26 140 E € ~ ! ~ ~ All 166 0 0 166 Descriptive statistics - Occasional smoking

C' UN Childhood 0-18 yrs, Number of smokers ALL CENTERS Totat Excosed Unexoosed Excluded Min P10 Q1 Median e 03 P90 ~ Max _ ~ Mean _ ~_ Std Men CasC3 141 75 65 1 1.00 1.00 1.00 1.00 1.00 2.00 4.00 1.25 0.64 Controls 531 321 201 9 1.00 1.00 1.00 1.00 2.00 2.00~ 5.00 ~ 1•42 0.75 L All 672 396 266 10 1.00 1.00 00 1.00 2.001 2.00~ 5.00 1.39_ _ 0.73 WofTHIn CB,Cs 509 314 187 8 1.00 1.00 1.00 1.00 1.00 2.00 5.00 1.33 0.70 Controls 1011 700 295 16 1.00 1.00 1.00 1.00 1.00~ 2.00 4.00 1.35~ 0.71 A1l 1520 1014 482 24 1.00 1.00 1•00 1.00 1.00 2.00 5.00 1.35 0.70 All CiSQS 650 389 252 9 1.00 1.00 1.00 1.00 1.00 2.00 5.00 1.32 0.68 CCnU015 1542 1021 496 25 1.00 1.00 1.00~ 1.00 2.00 2.00 5.00 1.38 0.72 An 2192 1410 748 34 1.00 1.00 1.00I 1.00 2.00 2.001 5.00 1.36 0.71 ALL CENTERS WITH CDUCATIONAL LEVEL AND TYPE OF RESIDENCE Mcn Cases 92 49 42 1 1.00 1.00 1.00 1.00 1.00 2.00 4.001 1.27 0.64 Controls 470 290 171 9 1.00 1.00 1.00 1.00 2.00 2.00 5.00 1.42 0.76 AN 882 339 213~ 10 1.00 1.00 1.00 1.00 2.00 2.00 5.00 1 1,40 0.7e WOrttM GisCS 406 258 140 8 1.00 1.00 1.00 1.00 1.00 '<.00 5.00 1,34 0.72 Contr0l6 868 616 239 13 1.00 1.00 1.00 1.00 2.001 2.00 4.00 1,37 0.73 AII 1274 974 379 21 1.00 1.00 1.00 1.00 1.00 2.00 5.00 1.36 0.73 All CSSCS 498 307 182 9 1.00 1.00'E 1.00 1.00 1.00 2.00 5.00 1.33 0.77 Controls 1338 906 410 22 1.00 ;.00I 1.00 q.00~ 2.00 2.00~ 5.00~ 1.39 0.74 All 1836 1213 592 31 1.00 .00i 1.00 .00 2.00 2.00 5.00~ 1.37 0.73 MCn CBses 104 a8 45 i 5.00 1.00 1.00 1.00 1.00 2.00~ 4.00 I 1.28 0.70 ConU015 306 185 118 3 1.00 1.00 1.00 1.00 1.00 2.00 5.00 / 1.28 0.5E AN 410 43 163 4 1.00 1.00 1.00 ',.00 1.00 1 2.00 5.00 1.28 0.59 Women Cases 40 250 149 6 1.00 1.00 1.00 1:.00 1.00 2.00 5.00 1.30 0.6: CDnUoIS 750I 532 211 7 1.00 1.00 1.00 1.00 1.00 2.00 4.00 1.27 0..6' All 1155 782 360 13 1.00 1.00 1.00 1.00 1.00 2.00 5.001 1.28 0.6: dN Cases SoB 308 194 7 1.00 1.00 1.00 1.001 1.00 2.00 5.OO 1.29 0.oc Controls 1056 717 329 10 1.00 1.00 1.00i 1.OOf 1.00 2.00 5.00 1.27 0.6C AII 1565 1025 523 '>7 1.00 1.00 1.00~ 1.00 1.00 2.00 5.00 1.28 C C: MCtI CaSCs I 14 4 10 0 1.00 1.00 1.00 1.00 1.50 2.00 2.00 1.25 0 5: Controls ~ 23 17 6 0 1.00 1.00 1.00` 1.00 1.00 2.00 2.00 1.24 0 41 All ° 37 21 16 0 1.00 1.00 1.00 1.00 1.00 2.00 2.00 1.24 C s Wofrien Cises b3 40 22 i.00 1.00 1.00 1.00 1.00 2.00 i 3.00 1.23 0 at Controls 128 97 31 0 1.00 1.00 1.00 1.00 1.00 2.00 4.00 1.21 0 t All 191 137 53 1 1.00 1.00 1.00 1.00 1.00 2.00 4.00 1.21 0 5" AA Cases 77 44 32 S 1.00 1_00 1.00 1.00 ?.00 2.00 3.00 .•23 C 4, ConUols 151 114 371 0 1.00 1.00 1.00 00 1.00 2.00 4.00i 1.21 0 5~ A11 228 158 69 1.00 ':.00 1.00 1.00 1.00 2.00 4.00 1.22 G 5 GERMANYI MCn I CaseS ConUOls All 18 129 147 11 75 86 7 53 60 0 1 1.00 1.00 1,00 1.00 1.00 '.00 1.00 1.00 ':.00 1.001 1.00 1.00 1.00 1.00 1.00 2.00 1.00 2.00 2.00 1.09 5.00 .24 5.00 1.22 05. C e 0 5F Women 58 34 22 1,00 1.00 1•00 1.00 1.00 2.00 3.00 1.18 C s• 100 77 21 2 1,00 1.00 1.00 1.00 1.00 2.00 2.00 1.21 0 4' 158 111 43 4 1.00 1.00 1.00 1.00 1.00 2.00 3.00 1,20 C a' AN Cases 76 45 29 2 1,00 1.00 5.00 1.00 i.00 2.00 3.00l 1.16 0 4. 229~ 152 74 3 1.00 5.00 t.00 1.00 1.00~ 2.00 5.00 1.22 C c: 305 197 103 5 1.00 1.00` 1.00 1.00 ?.00 2.001 5.00 1.21 0 Y GERMANY2 Men Cases 29 18 10 1.00 1.001 1.00 1.00 1.001 3.00 3.00 1.28 0.6` COnlrWS ' i"5 39 25 1~ 1.00 1.00 1.00 1.00 2•00 2.00 3.00 1.31 0.5` Alt 94 57 35 21 1.00 1.00 1.00 1.00 9.00 2.00 3.00 ?.30i 0.6C Women Cases 113 611 52 0 1.00 1.001 1.00 1.00 1_00 3•00 4.00 1.36 0,7 Controls 98 59 38 1 1.00 `.00 ',.00 1.00 1.00 2.00J 3.00 1.19 0.51 All 211 120 90 1•00 1 1.00 1.00 1:.00 1.00 2.001 4.00 1.28 0.6~ AII Cases ContrGs AIt 142 163 305 79 52 98l 63 177 125 ; 1.00 2 1.00 3 1.00 1.00 1•00 1.00 1.00 ( 1.00 1.00 1.00 1.00 1.00 1.00 3.00 1.00 2.00 1.00 2.00 4.00 3.00~ 4.00 L 34 1.23 1.28 0."' 0.5:. 0.6: GERMANY3 Men Cases 10 3 7 0 1.00 1•00 1.00 1.00 1,00 1.00 1.00 1.00 0.0C Controls 14 ? 6 '. .00 1•00 1.00~ 1•00 1.00 1.00 1.00 1.001 0.0: Al1 24 10 13 1 1.00 1.00 1•00 1.00 1.00 1.00 1.00 1.00 O.OC Women Cases 21 12 9 1 1•00 1.00 1.00 1.00 1.50 2.00 3.00 1.33 0.6; Conlr0i5 38 26 12 0 `:.00 1.00 1.00 1.00 1.00 1.00 1.00 ~ 1.00 0.0: Alt 59 38 20 1~ 1.00 1•00 1.00 1.00 1.00 1.00 3.00 1.11 0.35 AA G1ses 31 15 15 1.00 1.00 ':.00 1.00 1.00I 2.00 3.00 1.27 0.55 Controls 52 33 18 1.00 1.00 1.00 1.00 1.00 ! 1.00 1.00 1.00 0.0C All 83 48 33 ',.00 1.00 1.00 1.00 1.00' 1.001 3.00 1•081 0,3: ITALY 1 Men Cases 8 s 2 0 *<.o0 1.o0 1.00 1.50 2.00 2,00 2.00 ;.SO o.se SSS Controls ~ 103 70 28i 5 1.00 1.00 1.00V 1.00 2.00~ 3.00 1 5.00 1.67 0.9; Ap 111 76 ~ 30f 5 1.00 1.00 ?.00~ 1.00 2.00 3,00 5.00 1•66 0.9C w0(rien Cases 32 21 9 1.00 1.00 1.00 1.00 2.00 3.00 4.00 1.57 0.9e Controls 118 92 21! 5 1.00 1.00 1.00 1.00 2.00 3.00 4,00 1.79 0.9E Atl 150 113 301 7 1.00 1.00 1.00~ 1.00 2.001 3.00 4.00 1.75 0.98 AI! Cases 40 27 2 1.00 1.00 1.00 1.00 2.00 3•00 4.00 1.56 0. 65 Controls 221 162 49 10 1.00 1.00 1.00 '. .00 3.00 2,00 5.00 7a 1. o.9_ All 261 189 60. 12 00 1 1.00 1.00 00 1 2.003.00 5.00 1.71 27p63593333

C _c1 US Childhood 0-18 yrs, Smoking parent years ALLCENTERS Level oY exaoauro Hon exposetl 0<C1uS<19 19<C1US<31 31<C1US ALL CENTERS WITH EDUCATIONAL LEVEL AND TYPE OF RESIDENCE Non exposetl 149 350 1-00 0<c1uS<19 174 423 0.86 ( 0.65- 1.14) 19<C1US<31 91 283 0.84 ( 0.60- 1.19) 31<C1US 10 83 0.41 ( 0.20- 0.85) Exclud,wd/Trsnd 74 199 0.00 ALL CENTERS W1TH DIETARY DATA Non eXposetl 189 1.00 0<C1U3<.19 193 0.80 ( 0.61- 1.04) 19<C1US<.31 102 0.75 ( 0.54- ~ 1•03) 31<C1US 11 0.49 ( 0.24- f 0.99) X.vcludro11rr.ndj 14 FRANCE Non ex O<C1US 19<C1U3 0R12) 95% Cl 1 0 3) 95% CI OR 4 95% CI 1.00 1 1.00 1.00 0.88 ( 0.68- 1.13)/ 0.84 ( 0.63- 1.12) 0.83 ( 0.65- 1.05) 0.83 ( 0.62- 1.11) 0.85 ( 0.60. 1.20) 0.80 ( 0.61- 1.05) 0.48 ( 0.27- 0.86) 0.40 { 0.19- 0.82) 0.49 ( 0.29- 0•85) 0.00 0.00 0.00 1.00 1.00 ( 1•00 ( 0.86 ( 0.65- 1.14) 0•84 ( 0.63- 1.12) 0.85 ( 0.64- 1.14) 0.85 ( 0.60- 1.20) 0.85 ( 0.60- 1.20) 0.88 ( 0.62- 1.25) 0.41 ( 0.20- 0.85) 0.40 ( 0.19- 0.82) 0.39 ( 0.18- 0.82) 0.00 0.00 1 0.00 1.00 1•00 1.00 0.83 ( 0.64- 1.09) 0.83 ( 0.61- 1.12) 0•80,( 0.61- 1.04) 0.81 ( 0.58- 1.13) 0.86 ( 0.58- 1.27) 0.76 ( 0.55- 1.05) 0.47 ( 0.23- 0.98) 0.35 ( 0.13- 0.96)~ 0.51 ( 0.25- 1.03) 0. 01 ®Rf5) 95% CI 1.00 0.81 ( 0.75 ( 0.50 ( 0.00 0.62- 0.54- 0.25- 1.05) 1.03) 1•02) 1.00 ( 0.84 ( 0.63- 1.14) 0•84 ( 0.57- 1.24) 0.36 ( 0.13- 0.97) 0.00 posetl 32 37 1.00 1 1.00 1 1.00 1.00 1.00 <.19 20 48 0.51 ( 0.25- 1.04) 0.84 ( 0.37- i.87) 1.47 ( 0.49- 4.40)~ 0.49 ( 0.23- 1.00) 0.52 ( 0.25- f.07) <•31 23 59 0.45 ( 0.23- 0.90) 0.68 ( 0.32- 1.47) 1.03 ( 0.37- 2.86) 0.45 ( 0.22- 0.91) 0.46 ( 0.23• 0.91) $1<C1US 1 7 0.14 ( 0.02- 1.27) 0.00 ( 0.00-99.99) 0.00 ( 0.00-99.99) 0.14 (-0.02- 1.21) 0.14 ( 0.02- 1.24) 2xcludad/Trond 1 0 0.01 0.01 0.01 0.01 0.01 GERMANYI Non exposetl 0<C1US<.19 19<C1US<31 31<C1US Sxclud@d/Trand GERMANY 2 29 74 1.00 1.00 f.0o 1.00 1.00 34 106 0.60 ( 0.32- 1.13) 0.61 ( 0•30- 1.23) 0.60 ( 0.29- 1.21) 0.65 ( 0.34- 1.23) 0.63 ( 0.33- 1.20) 10 42 0.57 ( 0.24• 1.35) 0.71 ( 0.28- 1.79) 0.75 { 0.29- 1.94) 0.61 ( . 0.25- t.46)1 0.65 { 0.27- 1.59) 1 4 0.65 ( 0.06- 6.73) 1.21 ( 0.11-13.60) 1.19 ( 0.10-14.10) 0.76 ( 0.07- 8.14)i 0.94 ( 0.08-10.62) 2 3 0.14 0.13 0.16 E 0.15 1 0.19 eXpOSetl Non 62 63 1.00 1.00 1.00 1 1.00 1.00 0<CiUS<19 66 91 0.74 ( 0.45- 1.21) 0.75 ( 0.45- 1.23) 0.72 ( 0.44- 1.20) 0.73 ( 0.45- 1.20) 0.74 ( 0.45- 1.21) 19<CtUS<31 12 6 1.98 ( 0.67• 5.84) 2.21 ( 0.73- 6.68) 2.35 ( 0.76• 7.33) 1.97 { 0.67- 5.82) 2.00 ( 0.68- 5.90) 31<C1US 1 1 1.20 ( 0.07•22.10) 1.17 ( 0.06-21.49) 0.89 ( 0.05-16.97) 1.19 ( 0.07-21.78) l 1.25 ( 0.07•23.05)~ ~ Ekcludod/Trond 1 i ~^ 0.91 0.96 1 0.88 0.89 t 0.91 E GERMANY3 Non oxpoaetl 15 1US<.19 14 0<0 19<01US<.31 1 18 1.00 1.00 1.00 1,00 1•00 33 0.54 (, 0.19• 1.57) 0.52 ( 0.18- i.54) 0.51 ( 0.16- 1.59)~ 0.67 { 0.22- 2.04) 0.44 ( 0.14- 1.35) 0 99.99 ( 0.00•99.99) 99.99 ( 0.00-99.99) 99.99 ( 0.00-99.99)~99.99 ( 0.00•99.99) 99•99 { 0.00-99.99) Excluded/Trond 1 1 1 0.39 0.38 1 1 0.37 ~ 0.43 , 0.28 lTALY 1 Non exposeC 11 0<C1US<.19 13 19<C1US<31 10 31<C1US 4 c-XcludQd/rrond 2 49 1.00 1.00 1.00 1.00 54 0.90 { 0,35- 2.31) 1.15 ( 0.42- 3.17) 1.08 ( 0.37- 3.10) 0.88 ( 0.33- 2.35) 71 0.54 f, 0.20- 1.44) 0.75 { 0.26- 2.17) 0.80 ( 0.27- 2.35) 0.62 ( 0.23- 1.72) 37 0.35 ( 0.10- 1.25)I 0.51 ( 0.13- 1.96) 0.53 ( 0.13- 2•10)1 0.28 ( 0.07- i•17) 10 0.07 ffE 0.16 0.17 E 0.07 ( ITALY 2 Non exposetl 0<C1US<.19 19<C1US<31 31<C1US &cludad/Trsndl ITALY 3 Non axposetl 0<C1US<e19 19<C1US<31 31<C1US excluded/Trend PORTUGALI Non exposec 0<C1US<.19 19<C1US<31 31<C1US Excluded/Trond PORTUGAL2 Non exposetl 0<C1US<.19 19<C1US<31 31<C1US Ezcluded/Trlnd SPAIN Non eXpoSetl 0<C1US<.19 19<C1us<31 31<C1US Ex0ludadIrrend 2 10 0 0 OR(1) 95% 1.00 CI 0.83 ( 0.65- 1.05) 0.78 ( 0.60- 1.03) 0.49 ( 0.28- 0.83) 1.00 1.17 ( 0.21- 6.55) 2.73 ( 0.86- 8.65) 1.25 ( 0.13-12•42) 0.26 19 1.00 3 0•47 ( 0.07. 3•16) 20 0.79 ( 0.20- 3.10) 3 0.00 ( 0.00-99.99) 01 0.29 151 1.00 8! 0.79 ( 0.24• 2.58) 10 0.80 ( 0.25- 2.52) 3 0.62 ( 0.11- 3.60) 9 0.54 1.00 1.00 1.99 ( 0.31-12.90) 0.91 ( 0.07-11.28) 4.54 ( 1.13-18.34) 1.85 ( 0.38- 8.93) 3.19 1 ( 0.27-38.06) 1.66 ( 0.11-25.22) 0.06 ~ 0.12 ( 1.00 ~ 1.00 0.44 !, 0.06- 3.12) 0.32 ( 0.04- 2.86) 0.69 ( 0.16- 3.02) 0.44 ( 0.08- 2.33) 0.00 ( 0.00-99.99) 0.33 ( 0.00-99.99) 0.28 0.48 1.00 1.34 ( 2.91 ( 1.34 ( 1 0.22 1.00 0.51 ( 0.62 ( 0.00 ( 0.20 1 00 0.23- 7.69)1 0.91- 9.34) 0.13-13.53) ( 1.00 0.07• 3.42) 0.46 ( 0.05- 3.85)1 0.15- 2.60) 0.79 ( 0.16- 3.92)1 0•00-99.99) 0.00 ( 0.00-99.99) 1 0.29 . 0.77 ( 0.24- 2.52)1 ~ 0.77 ( 0.24- 2.46)1 ` 0.94 ( 0.13- 6.63)~ ~ 0.50 11 17 26 1.00 1.00 1.00 8 13 0.99 ( 0.32- 3.05) 0.93 ( 0.24- 3.54) 0.86 ( 0.27- 2.78) 7 12 0.92 ( 0.29- 2.95) 0.49 ( 0.13- 1.77) 0.91 ( 0.28- 2.9a) 1 2 0.86 ( 0.06•11.40) 1.05 ( 0.08-14.33) 0.96 ( 0.07•12.79) ~ 0 0 0.87 0.89 0.82 13 32 1.00 1.00 1.00 1.00 1 1,00 23 36_ 1.62 ( 0.69- 3.80)1 1.30 ( 0.54- 3.11) 1.39 ( 0.56- 3.48) 1.51 ( 0.64- 3.56) 1,66 ( 0.70- 3.94) 31 77 0.93 ( 0.43- 2.04) 0.77 ( 0.34- 11.76) 0.88 ( 0.37- 2.06) 0.95 ( 0.43- 2.09) 0.90 { 0.41- 2.00 ) 2f 10 0.49 ( 0.09- 2•60)1 0.36 ( ~ 0.07- 1.97) 0.43 ( 0.08- 2.40) 0.45 ( 0.08- 2.45) 0.58 ( 0.11- 3.18) 2! 4 0.33 0.33 ) 0.44 0.32 ) 0.39 SWEDEN Non exposetl 0<C1US<19 19<C1US<31 31<C1US 29 45 1.00 1.00 1.00 1•00 19 29 1.02 ( 0.4$• 2.18) 0.99 (, 0.46- 2.13) 0.98 ( 0.45- 2.11) 0.96 ( 0.44- 2.07) 17 ~ 32 0.81 ( 0.37- 1.74) 0.77 ( 0.35- 1.66) 0.76 ( 0.35- 1.66) 0.74 ( 0.34- 1.63) S I 6 1.35 ( 0.36- 5.10) 1.17 (, 0.30- 4.52) 4 1.41 ( 0.37- 5.29) 1.51 ( 0.39- 5.78) Excluded/Trand O EEEi 0 0.99 ~ 0.83 E ~ 0.97 0.99 UNITED KINGDOM Non exposed 0<C1US<19 19<C1US<31 31<C1US &cludied/Trand 41 1.00 1.00 1.00 1. 00 t.oo ~ 17 731 1.32 ( O.SD•,3.50) 1.22 ( 0.45• 3.30) 1•15 ( 0•42• 3.14) 1.12 ( 0.41- 3•02) 1.45 ( 0.54- 3.90) 1 8 0.77 ( 0.08• 7.54) 0.76 ( 0.08• 7.58) 0.75 ( 0.07- 7.46) 0.72 ( 0.07- 7.15) 0.90 ( 0.09- 5.04) 1 18 0.21 ( 0.02- 2.39) 0.14 ( 0.01- 2.00) 0.12 (, 0.01- 1.79) 0.20 ( 0.02- 2.42) 0.19 ( 0.02- 2.31) 0 01 0.22 0.17 1 0.13 1 0.19 0.22 (1) Mode( inc)udo sex, center, sox'center and age (2) Model )neAldo sex, center, sex'conter, apo and proporlion of residential type in the last 35 yrs (REUP) (3) Model Include sex, Oenter, sex'canter, ape, proportion of residential type in the last 35 yrs (REUP) and educational level (EDUC) {R) h1aQa( mWe sex, ventar, sex-centsr, age and ducation of exposure to tist A agents (OCtAY) (5) Model'utc)ude sex, center, sex•centor, age and frequency consumption of vegetables (VEGE) '7 30 50 14 2 Excludid/Trandl 9! 25! 0.00 1 2;063593319 Risk estimates - Childhood 0-18 years-

©_~.1WS Childhood 0-18 yrs, Weighted smoking parent years MEN ONLY Levelot surc t Cases Controls ORN) 955L Ct ©R(21 95% G DR(3 95!G G OR{4) 95% CI ( OR(5) 95% Cf ( NE.' G1WS<•14 120 389 1.00 1.00 1.00 1.00 1.00 14<C1WS<.18 11 93 0.38 ( 0.17• 0.82) 0.45 ( 0.20- 1.00) 0.46 ( 0.16- 1.36) 0.38 ( 0.17- 0.82)1 0.26 ( 0.10- 0.77) 18<CiWS 9 40 0.54 ( 0.23- 1.29) 0.61 ( 0.23- 1.63) 1.06 ( 0.33• 3.40) 0.56 ( 0.23- 1.38) 0.65 ( 0.23• 1.80) €XCludid/Trend 11 9 0.01 ~ 0.01 0.02 o,0f ~ 0.01 ; WOMEN ONLY NE., C1WS<14 14<C1W3<.18 18<C1WS 380 689 1.00 1.00 1.00 1.00 1.00 93 239 0.83 ( 0.62- 1.12) 0.85 ( 0.62- 1.17) 0.91 ( 0.63• 1.33) 0.85 ( 0.63- 1.15) 0.86 ( 0.61- 1.23) 28 67 1.03 ( 0.63• 1.68) 0.90 ( 0.52- 1.55) 0.83 ( 0.45- 1.53) 0.96 ( 0•58• 1.59) 1.15 ( 0.62• 2.15) EXCludsd/Trond1 15 0.43 0.44 0.45 ~ 0.41 ~ 0.42 ~ POPULATION BASED STUDIES NE., C11YS<14 317 - 708 1.00 1.00 1.00 1•D0 ( 1.00 54<C1WS<.18 39 161 0.84 ( 0.55- 1.29) 0.90 ( 0.56- 1.38) 1.01 ( 0.58- 1.77) 0.89 ( 0.58- 1.36) 0.86 ( 0.49- 1.51) 18<C1W5 ~ 16 63 0.82 ( 0.44- 1.51) 0.88 ( 0.47- 1.64) 0.97 ( 0.46- 2.07) 0.78 ( 0.42- 1.47) 1.24 { 0.57- 2.69) ~XCludad/rrand 6~ 18 0.35 0.33 0.33 0.36 0.37 ~ HOSPITAL BASED STUDIES NE., ctws<.ta 161 255 1.00 1.00 1.00 1.00 1.00 14<C1WS<.18 64 166 0.66 ( 0.46- 0.96) 0.65 ( 0.43- 0.98) 0.75 ( 0.46- 1.20) 0.67 ( 0.46- 0.98) 0.66 ( 0.44- 1.01) 18<CiWS 18 24 0.95 ( 0.48• 1.85) 0.67 ( 0.28- 1.60) 0.94 ( 0.34- 2.59) f 0.99 ( 0.50• i.96) 0.81 ( 0.33- 2.00) fxcl0ded/rrtnd 3~ 7 0.08 0.07 ~ 0.11 0.07 ~ 0.08 6VITHOUT OCCASIONAL SMOKERS NE., ciw5<.1, 377 788 1.00 1.00 1.00 1.00 1.00 ( 14<CiWS<18 77 225 0.93 r, 0.67- 1.30) 0.98 ( 0.69- 1.41) 1.05 ( 0.70- 1.58) i 0.95 { 0.68- 1.33) 1.05 ( 0.70- 1.59) 18<C1WS 26 74~ 0.94 ( 0.56• 1.57) 0.82 ( 0.46- 1.47) 0.83 ( 0.44• 1.59) 0.85 ( 0.49- 1.45) 0.93 { 0.46- 1•88) Excltldtd/Trend 61 17! 0.65 0.65 ~ 0.73 II 0.63 0.71 AGE <55 YEARS N€.t C1W5<14 14<C1WS<.18 98<C1WS 125 242 1.00 1.00 1.00 1.00 1.00 24 79 0.66 ( 0.37- 1.18) 0.71 ( 0.37- 1.37) 0.90 ( 0.40- 1.99) 0.69 ( 0.38- 1,26)i 0.47 ( 0.23- 0.96) 15 36 0.95 ( 0.47• 1.91) 1.16 ( 0.54. 2.52) 1.04 ( 0.42- 2.62) I 0.95 ( 0.46• 1.96)1 1.23 ( 0.52- 2.90) Excludsd/Trend f~ 4 0.37 6 0.37 ~ 0.41 0.33 ~ 0.36 AGE 65-64 YEARS NE., C1w'S<014 19 74 05 1.0 0 1•00 1.00 1.00 1.00 14<C1WS<r18 7 7 6 ( 0.0.39- 1.13) 0.65•( 0.37- 1.13) 0.71 ( 0.36• 1.39) 0.70 ( 0.41- 1.19) 0.60 ( 0.30- 1.19) 18<C1WS 3 3 ( 0.43- 1.98) 0,79 ( 0.34- 1.83)1 1.01 ( 0.39- 2.60) 0.85 ( 0.39- 1.87) 0.88 ( 0.35- 2.21) Excluded/Trend 4 131 0.26 0.27 ' 0.24 ~ 0.27 0.25 1 AGE 85+ YEARS NE., G1WS<14 94<CiWS<10 18<C1WS 206 431 1.00 , 1.00 1.00 1.00 1.00 55 154 0.85 ( 0.57- 1,26) 0.90 ( 0.59- 1.37)1 0.93 ( 0.56- 1.56) 0.82 ( 0.55- 1.23) 1.00 ( 0.63- 1.58) 10 36 0.64 ( 0.27- 1.49) 0.51 ( 0.20- 1.31) 0.63 ( 0.22- 1.80) 0.62 ( 0.27- ?.46)~ 0.77 ( 0.27- 2.25) Excladed/rrend[ 4 ~ 8~ 0.24 0.24 ~ 0.27 0.18 ( 0.25 HISTOLOGICALLY CONFIRMED DIAGNOSIS NE., O1WS<s14 14<C1WS<e18 18<C1WS Excluded/rrend! 483 100 35 .91 1078 332 107 251 1.00 0.74 0.87 0.06 ' ( 0.56- ( 0.56- 0,98) 1.33) 1.00 0.77 ( 0.83 ( 0.06 0.57- 1,04) 0.51- 1.34) ( 1.00 0•83 ( 0.58- 0.87 ( 0.50- 0.07 1.18) 1.52) 1.00 0.76 ( 0.83 ( 0.06 1.00 0•57- 1.00) 0.74 C 0.53- 1.30) 0.97 ( i 0.07 0.53- 0.56- 1.03) 1.66) SQUAMOUS CELL CARCINOM A NE., C1WS<14 14<C1WS<18 18<C1WS cxcluded/Trand~ SMALL CELL CARCINOMA 87 12 9 1078 1,00 332 0.53 107. 1.24 251 0.41 ( 0.27- ( 0.57• 1.03) 2.73) 1•00 0.53 ( 1.03 ( 0.40 E 0.25• 1.10)! 0.39- 2.71)~ IIIEEE 1.00 0.76 ( 0.33• 1.49 ( 0.53- 0.39 1.74) 4.17) 1.00 0.53 ( 0.99 ( 0.39 0.27- 1.04) 0.41• 2.36)I j 1.00 0.47 ( 0.87 ( 0.41 0.20- 0.25- 1.11)` 2.97)1 ~ NE., C1WS<.14 60 1076 1.00 1,00 1 .00 1.00 1 1.00 ~ 14<0 1WS<.18 7 332 0.87 ( 0.35- 2.16) 0.87 ( 0.34- 2.20) 0.89 ( 0.31- 2•51) 0.93 ( 0.37- 2.32) 0.87 ( 0,32• 2.35) 18<C1WS II 2 107 0.87 (, 0.20• 3.87) 0.87 ( 0.19- 3.91) 0.44 ( 0.06- 3.52) 0.94 ( 0.21• 4.24)~ 0.50 ( 0.06• 3.92) Excluded/Treno'I il 251 0.74 0.69 ~ 0.69 0.74 I 0.75 ADENOCARCINOMA NE., CiWS<14 259 1078 1.00 1.00 t 1.00 1.00 ; 1.00 14<C1WS<18 ~ 54 332 0.67 ( 0.47- 0.95) 0.69 ( 0.47- 1.01) 0.72 ( 0.45- 1.16) 0.67 ( 0.47- 0.96)i 0.65 ( 0.43- 0.99) 18<CiWS 15 107 0.70 ( 0.38• 1.29) 0.73 ( 0.38• 1.41) 0.88 ( 0.42- 1.85) 0.70 ( 0.38- 1.30)I 0.92 ( 0.45- 1.88) .xcluded/rrendl 6 25~ 0.02 t 0.02 ~ 0.03 ~ 0.02 ~ 0.02 OTHER NE., Ciw5t•14 7 1078 1.00 1•00 1•00 1.00 1.OD ( 14<C1WS<18 1 271 332 1.07 ( 0.64- 1.77) 1.24 ( 0.73• 2.12) 1.24 ( 0.66- 2.34)i 1.12 ( 0.68- 1.87) 1.26 ( 0.70- 2.27) 18<C1WS j f 9 107 1.20 0.56• 2.56) 1.15 ( 0.49- 2.68) 0.87 ( 0.29- 2.58)1 1.27 f, ~ 0.59- 2.71) 1•75 ( 0.73- 4•22) ExCluded/TrOnd L 2 ~ 251 0.64 0.64 ~ 0.63 ~ 0.63 ~ 0.63 >761G OF LIFESPAN IN RURA AREA OR INTERMEDIATE CITIES NE., O1WS<14 221 434 1.00 1.00 1.00 1 1.00 1.00 14<C1WS<.18 26 95 0.56 ( 0.33- 0.98) 0.56 ( 0.33- 0.98) 0.55 ( 0.26- ?.17) 0.58 ( 0.33- 1.00) 0.58 ( 0.31- 1,07) 18<C1WS 5 41 0.37 (, 0.14- 0.99) 0,37 ( 0.14• 0.99) 0.41 ( 0.13• 1.28) 0.30 ( 0.10- 0.87) 0.36 ( 0.12- 1.09) cxcludad/rrond 41 5 0.01 ~ 0.01 ! 0.01 ~ 0.01 0.01 a765G OF LIFESPAN IN URBAN AREA NE., G1w5<14 174 a5a 1.0o 1.00 1.00 1.00 1.00 14<C1WS<18 ~ 53 191 0.80 ( 0.54• 1.19) 0.80 ( 0.54- 1.19) 0.93 ( 0.59- 7.47)1 0.84 ( 0.56• 1.25) 0.74 ( 0.46- 1.19) 18<C1WS 13 51 0.84 ( 0.42. 1.66) 0.84 ( 0.42- i.66) 0.91 ( 0.40- 2.05)f 0.78 ( 0.38- 1.59) 1.25 ( 0.52- 2.99) ~ 6xcluded/Trend 41 15 0.28 0.28 0.28 ~ 0.27 0.27 ; (1) Madel include sex, canter, sox•eenter and age (2) Model incfude sax, eenter, sax'center, age and proportion of residential type in the last 35 yrs (REUP) (3) Model inelOdo sox, cantor, sex'center, age, propoation of residential type in the last 35 yrs (REUP) and educational level (EDUC) (d) Mad®1 inek~ds ssx, eanter, sex•center, ago and duraLOn of exposure to hst A agents (OCLAY) - (5) Modof Includo sox, canter. sox'canter, age and frequency consumption of vegetables (VEGE) Risk estimates - i,hildhood 0-18 years

Occasional smoking, Cumulative exposure (packs/Jifetime) ALL CENTERS LaveI of axpOture NE.~ 05CU<6 g<OSCU<12 12<OSCU Controls ORI'p 95Y. CI OR12) 95% CI OR(3) 95% CI } OR(4) 95% C) j_ OR(5~ 957. CI 1259 ?.00 1.00 1 1.00 100 . 1.00 521 0.70 { 0.39• 1.27)1 0.68 ( 0.36- 1.31) 0.82 ( 0.37- 1.82) 0-68 ( 0.37- 1.25) 0.80 ( 0.41- 1.54) 33 0.92 ( 0.45- 1.90) 1.04 ( 0.48- 2.26)! 1.13 ( 0.40- 3.14) 1.04 ( 0.60- 2.14) 0.88 ( 0.36- 2.16) 1881 0.43 ~ 0.42 ~ 0.45 ALL CENTERS WiTH EDUCATIONAL I.EVEL AND TYPE OF RESIDENCE NE., OSCU<6 379 929 1.00 1.00 1.00 1.00 1.00 3<OSCU<r12 9 35 0.81 ( 0.37• 1.78) 0.82 ( 0.37• 1.81) 0.82 ( 0.37. 1.82)~ 0.75 ( 0.33- 1.73) 0.99 (, 0.43- 2.26) 12tOSCU 6 21 1.10 ( 0.40- 3.03) 1.08 ( 0.39- 3.00) 1,13 ( 0.40- 3.14) 1.11 ( 0.40- 3.08) 1.02 ( 0.27- 3.83) Fxcludad/Trtnd 104 353 0.51 0.50 ) 0.54 ~ 0.51 0.48 ALL CENTERS YdITH DfETARY DATA NE,~ OSCUC5 442 8T1 1.00 1.00 ( i.00 1.00 1.00 S<OSCUt.12 14 35 0.78 ( 0.41- 1.51) 0.74 ( 0.37• 1.47) 0.96 ( 0.42- 2.21) 0.73 { 0.37- 11.44) ~ 0.80 ( 0.41- 7.54) 12<OSCU 8 16 0.93 ( 0.38- 2.27) 1.20 ( 0.48. 3.01) 1.07 ( 0.29- 4.00) 0.96 ( 0.39- 2.34) 0.88 ( 0.36- 2.16) 1 2XCludtd/Tttnd 45 f94 0.55 0.56 0.55 0.55 ~ 0.50 FRANCE NE., OSCU<5 64 129 1.00 1.00 1 .00 1.00 t.oo 5<03CU<12 8 12 1.29 ( 0.49- 3.38) 1.33 { 0.46- 3.86) 1.47 ( 0.42- 5.16) 1.24 ( 0•47- 3.27) 1.31 ( 0.50- 3.45) 12<OSCU 5 10 0.97 ( 0.31- 3.07) 1.15 { 0.33- 3.97) 1.01 ( 0.18• 5.75) 0.95 ( 0.30- 3.02) 0.92 ( 0.29- 2.95) €xc1udtd/Trandl 0 0 0.85 0.85 0.84 ) 0.94 0.89 GERMANY1 NE., 0SCU<5 5<OSCU<a12 12<OSCU 72 212 1.00 1-00 1.00 1.00 1.00 3 7 1.07 ( 0.24- 4.76) 1.33 ( 0.28- 6•43)~ 1.44 ( 0.30- 6,81) 0.69 ( 0.12- 3.96) 1.16 ( 0.25- 5.35) 0 3 0.00 ( 0.00-99.99) 0.00 { 0.00-99.99) 0.00 ( 0.00-99.99) 0.00 ( 0.00-99.99) ) 0.00 ( 0.00•99.99 1~ €xcludad/Trandl 7~ 0.58 0.54 ~ 0.55 0.69 ( 0.56 GERMANY2 NE., OSCU< 5 141 158 1,00 1.00 1.00 1.00 1.00 6<OSCU<12 0 3 0.00 ( 0.00-99.99) 0.00 ( 0.00•99.99) 0.00 ( 0.00•99.99) 0.00 ( 0.00-99.99) 0.00 ( 0.00-99,99j 12<OSCU ~ ? 1 1.05 ( 0.06-18.51) 1.02 ( 0.06-17.87) 1.19 ( 0.06-23.23) 1.04 ( 0.06-18.42} 1.t0 ( 0.06-19.58j Exclllded/Trtndl 0 11 0.42 ~ 0.40 ~ 0.45 0.41 0.42 ( GERMANY3 O5CU<5 NE., 5<03CU<.12 30 60 1.00 i.00 1.00 1.00 1.00 0 99.99 ( 0.00-99•99) 99.99 ( 0.00-99.99)~99-99 ( 0.00-99.99)~ 99.99 ( 0.00-99.99) 99.99 ( 0.00-99.99) €XCludtd/Trend 0 21 0.99 ~ 0.99 ~ 0.99 ~ 0.99 0.99 NE., USCU<.5 40 186 1.00 1.00 1.00 1.00 ( 5<OSCU<.12 0 90 0.00 { 0.00-99.99) 0.00 ( 0.00-99.99) 0.00 ( 0,00-99.99) 0.00 ( 0.00-99.99) f 12<O5GU 0 9 0.00 ( 0.00•99.99) 0.00 ( 0.00-99.99) 0.00 ( 0.00-99.99) 0.00 ( 0.00-99.99) ~ €xcluded/Trend 0 6 0.97 1 0.97 0.97 0.97 ITALY 2 N., 0SCU<5 ~ 6<OSCU<1 !2 12<OSCU cxcluded/Trandl ITALY 3 HE., OSCU< 163 3 S 17 0 2 2 0.34 iii I 0.43 i 0.16 6 16 46 1.00 1.00 1.00 o 1 00 1.00 5<OSCU<•12 0 ~ 3 0.00 ( 0,00-99.99} 0.00 ( 0.00-99.99) 0.00 ( 0.00-99.99) 0.00 ( 0.00-99.99) 0.00 ( 0.00-99.99) 12<OSCU 0 ~ 1 0.00 ( 0-00•99.99) 3.01 ( 0.00-99.99) 0.12 ( 0.00•99.99) 0.00 ( 0.00-99.99) __ 0~ Sxcl ud'td/Trendl 0 0.97 0.97 { 0.97 0. 96 0.97 PORTUGALI NE., OSCU<5 1 42 3<OSCU<:12 j 2 12<OSC fU 2 Excludad/Trend a PORTUGAL2 NE., OSCU<5 { 28 5<05CU<r12 1 12<OSCU €xcluded/Trendl 4 SPAIN NE., OSCU<5 60 5<OSCU<12 0 I SWEDEN NE, OSCU<5 5<0SCU<r12 12<OSCU €xcluded/Trend €xcludtd/Trend UNITED KINGDOM r 33 1.00 2 0.44 ( 1 1.42 ( 31 0.93 1.00 3 133 2 24 0 1.00 1.00 1.00 1.00 0.00 ( 0.00•99•99)~ 0.00 ( 0.00-99.99)~ 0.00 ( 0.00•99.99)I 0.00 ( 0.00-99.99) 4.99 ( 0.68•36.86) 3.39 ( 0.36•31.44) 18.17 ( 0.84-99.99)llt 5,01 ( 0.68-36.95) 0.16 1.74 ( 0.00 ( 0.73 1.00 0,00 ( 0.99 1.00 0.35 ( 1.84 ( €xcluded/Trendl 26~ 140 (1) Model Include sex, canter, seat'center and age 0.05• 3.81) 0.12-17.04) ( 1.00 0.10-30.17) 0.88 { 0.04-20.12) 0.00-99,99)" 0.00 ( 0.00-99•99) 0.58 1.00 0.00-99.99)1 0.00 ( 0•00-99.99) ! 1 0.99 1.00 0.07• 1.79) 0•38 ( 0.07- 1.92) 0.25-13.76) 1.90 ( 0.25-14.43) 1.00 0.00 ( 0.00-99.99) 0.99 (2) Model {nclude Sex, center, sex'eenter, age and proportion of residential type in the last 35 yrs (REUP) (3) Modet Include aex, center, sex•center, age, proportion rtion of residential type in the last 35 yrs (REUP) and educational level (EDUC) ;4) Model Include sex, center, saX'center, age and duration n of exposure to list A agents (OCLAY) (5) Model Include sex, center, sex'center, age and frequency consumption of vegetabies (VEGE) €Xcluded/Trendl 451 1.00 0.41 ( 0.05- 3.62) 99.99 ( 0.00-99.99) 0.97 1•00 0.00 ( 0.00-99.99) 0.99 1.00 0.00 ( 0.00-99•99)1 0.99 Risk estimates - Occasional smoking

c1WS Childhood 0-18 yrs, Weighted smoking parent years ITALY 2 Total ExDOsed Unex0o5ad Exduded Mln P10 01 ~ Median ~ 03 1 P90 Max ~ Mean Std E Men Cases 3 1_ 2 0 0.13 0.13 0.13 0.13 0.13 0.13 0.13 0.13 COn17014 97 35 41 1 0.25 4.00 9.00 14.25 14.25 19.00 27.25 12.38 6.171 All 100 56 43 1 0.13 1.50 8.44 14.251 14.25 19.00 27.25 12.16 6.331 WOmCn 03sCS 16 12 4 0 12.25 13.88 14.25 14.25 14.75 15.75 33.25 15.851 5.54 Controls 76 39 36 1 0.75 3.38 10.13~ 14.25 15.25~ 19.00~ 34.38 12.98 6.74 All 92 51 40 1 0.75 4.50 12.25 14.25 15.00 16.881 34.38 13.65 6.54 AN CBses 19 13 6 0 0.13 12.25 14.25 14.25 14.75 15.75 33.25 14.64 6.86 Controls 173 94 77 2 0.25 4.00 9.38 14.25 14,63 19.00 34.38 12.63 6.38 All 192 107 83 2 0.13 4.00 10.13 14.25 14.75 19.00 34.38 12.87 6.44 ITALY 3 Men Ca.es 1 0 1 0 Controls 12 5 7 0 1.38 1.38 10.88 14.25 14.25 14.25 14.25 11.00 5.58 All 13 5~ 8 0 1.38 1.38 10.88 14.25 14.25 14.25 14.25 11.00 ~ 5.58 Women C3 15 9 6 0 6.38 6.38 14.25 94.25 14.25 16.25 16.25 12.72 3.66 Controls 38 26 12 0 4.13 6.38 14.25 14.25 14.25 19.00 34.25 14.73 6.50 AII 531 35 18 0 4.13 6.38 14.25 14.25 14.25 16,251 34.25 14.21 5.92 AB CasCS 16 9 7 0 6.38 6.38 14.25 14.25 54.25{ 16.25 16.25 12.72 3.66 COnttola 50 31 19 0 1.38 6.38 13.88 14.25 1 4.251 16.00 34.25 14.13~ 6.43 All 66 40 26 0 1.38 6.38 14.06 14.25 14.25~ 16.13 34.25 13.81 5.91 PORTUGALI Men CaBCs 16 6 10 0 10.50 10.50 10.88 16.06 19.00 19.00 19.00 15.25 4.20 Controls 8 4 4 0 9.38 9.38 11.81 16.63 19.69 20.38 20.38 15.75 4.99 All 24 10 14 0 9.38 9.94 10.88 16.63 19.00 19.69 20.38 15.45 4.27 WOnSC71 CaSCa 33 ';9 14 0 3.38 3.50 4.75 14.25 19.00 22.88~ 23.75 12.67 6.82 Controls All 31 64 17 36 11 25 3 3~ 0.25 0.25 3.50 5.63 3.50 5.19 14.251 14.25 14.25 14.25/ 18.50 19.00 19.00 23.75 ~ 10.89 5.56 11.83 6.24 AIl CasCi Controls AII 491 39 88 26 21 46 24 15 39 0 3 3 3.38 0.25 0.25 3.50 9.38 4.13, 7.88 3.501 7.88 14.25 14.25 14.25 19.00! 14.25I[ 19.00 19.00 23.75 19.00 20.38 19.00 23.75. 13.29~ 6.31 11.82 5.69 12.621 6.01 PORTUGAL2 Man CaSef 10 4 6 ] ~ 0 5.63 5.63 9.00 12.38 13.31t 14.25 14.25 11.16 3.79 Controls ~ 17 7 101 0 1.38 1.38 4.13 14.25 14.25~ 35.00 35.00 12.70 11.231 Aq 27 ':1 ?6 0 7.38 4.13 5.63 12.38 14.25 14.25 35.00 12.14 8.96 womcn G85C5 - 23 12 11 0 5.00 8.63 9.00 13.88 14.25 14.25` 18.00 12.17 3.59 COr11f0if ~ 36 20 16 0 0.25 1.13 4.25 13.31 14.25 16.00 18.50 10.04 6.00 All 59 32 27 0 0.25 1.38 7.50 13.50 I 14.25f 15.25 18.50 10.84 5.26 All Cases 33 16 17 0 5.00 5.63 9.00 12.94 ?4.25 14.25 18.00 11.91 3.54I Corltrola 53 27 26 0 0.25 1.38 4.13 13.50 14.25 16.75 35.00 10.73 7.53 ! All 86 431 43 0 0.25 1.38 5.63 13.50 14.25 15.251 35.00 11.17 ` 6.32 SPAIN hten Cases ~- 6 4 2 0 14.25 14.25 14.25 14.25 16.50 18.75 18.75 15.38 2.25 Controls 13 12 1 0 9.38 13.50 14.06 1 :4.251 14.25 14.75 17.00 1.701 14.02 All 1 9 6 1 3 0 9.38 13.50 14.25 14.25~ 14.25 17.00 18.75 ~ .36 1.87} 14 WOmon Cases 65 52 11 2! 0.38 1.63 9.19 1.4.25 14.25 15.63 23.75 5.06 11.62 Controls 146 111 31 41 1.00 7.50 1Z 38 14.25 14.25 15.88 19.50 12.91 3.81 All 211 163 42 6 0.38 4.88 10.88~ 14.25 14.25 15.88 1 23.75 12.50 4.28 Al! 71 56 13 2 0.38 t.63 10.13 14.25 14.25 t6.00 23.75 11.89 5.00 Controls AN 1591 230 123 179 32 45 4 6~ 1.00 0.38 7.88 5.63 13.13 11.63 14.25 14.25 14.25~ 14.25 15.88 16.00 19.50 23.75 13.02 3.67 12.67~ 4.15 MCn CiSCS ~ ^3 16 7 0 1.00 1.63 6.56 10.88 13.69 15.75 27.13 10.45 6.32I 1 Controls 36 20 16I 0 1.13 3.25 12.75 14.25 /7.19 28.25 33.25 14.90 8.17I All 59 36 23i 0 1.00 ~ 2.63 9.00 13.50 14.56 I 23.25 33,25 12.92 7.64. I Women CasS 47 25 22 0 0.75 4.25 10.63 14.25 14.25 17.75 33.25 12.98 6.47 Controls 76 47 29 0 0.38 4.13 8.63 14.25 14.25 16.00 33.25 12.40 6.15 All 123 72 Si 0 0.38 4.25 9.00 14.25 14.25 '6.25 33.25 12.60 6.22 Atl CasC3 70 41 29 0 0.75 3.63 8.38 13.13 14.25 17.50 33.25 11.99 6.45 Controls All 112 182 67 108 45 74 0 0 0.38 0.38 3.88 3.63 9.38 9.00 14.25 14.25 14.25 14.25 17.50 17.50 33,25 33.25 13.15 12.71, "0.85 6.59 UNITED KINGDOM Men lr.7scs 3! 2 1 0 13.88 13.88 13.88 13.88 73.88 13.88 13.88! 73.88 0.00 Controls 14I 10 4 0 0.88 1.75 13.13~ 13.56 30.63 32.38 32.38 16.84 11.45 All E 17 12 5 0 0.88 2.63 13.13 13.75 ~ 23.38 32.36 32.38 16.341 10.42 WOR1Cn CiSfS 23 17 5 0 3.38 8.50 13.13 13.13 13.68 18.50 34.38 14.36 6.15 Controls ~ 126 89 37 0 1.50 6.50 13.13 13.88 13.88 30.63 32.75 14.85 7.53 AII 149 106 43 0 1.50 7.13 13.13 13.13 13.88 30.63 34>38 14.77 7.31 All CaSCS 26 19 7 0 3.38 8.50 13.13 13.13 13.88 18.50 34.38 54.31 5.80 Controls 140 99 41 0 ~ 0.88 4.75 13.13 13.63 14.63 30.63 32.75 95.05 7.96( AIl 166 118 48 0 0.88 6.50 13.13 13.56 , 14.13 30.63 34.38 14.93 7.64~ _~~OJ~ 7 J+74t'~

Occasional smoking, Cumuiative exposure (packsAifetime) MEN ONLY LW!) Ot: %pOiUrO Non exposed 0<OSCU<5 6<0SCU<12 12<OSCU fxcl udsd/Trrnd WOMEN ONLY QR11) 957: C 9 OR(2) 959. CI ) OR(3) 95% CI ( OR(4) 95% Cl [ OR(5) 95% Cl ~ 1.00 1.00 1 1.00 E 1.00 ( 1.00 0,76 ( 0.42. 1.38) 0.87 ( 0.47- 1.62) 0.74 ( 0.31- 1.77) 0.75 ( 0.41- 1.37) 0.52 ( 0.25- 1.10) 0.86 ( 0.34- 2.18) 0.79 ( 0.26• ~ 2.42) 0.33 ( 0.04- ~ 2.$4) 0.72 ( ~ 0.27- 1.88) 0.75 ( 0.24• 2.31) 0.38 ( 0.10. 1.49) 0.59 ( 0.15- 2.37) 0.52 ( 0.09- ' 3.06) 0.48 ( 0.12- 1.87) 0.56 ( 0.13- 2.45) 0.24 0.24 € 0.27 ( 0.26 0.23 Non oxpoza 378 682 1.00 1.00 t.oo 1.0o 1.00 p<OSCUaS 76 138 1.14 ( 0.79- 1.64) 1.22 ( 0.83- 1.79) 1.37 ( 0.83- 2,25) 1.18 ( 0.81- 1.71) 1.01 ( 0.67 53) - 4. $<OSCU<12 8 27 0.58 ( 0.26- 1.32) 0.68 ( 0.30- 1.56) 1.15 ( 0.47• 2.84) 0.63 ( 0,28- 1.45) 0.73 { 0.31• 1.70) 12<OSCU a 14 1.46 ( 0.60- 3.54) 1.39 ( 0.53• 3.67) 1.64 ( 0.44- 6.15)1 1.51 ( 0.62- 3.66) 1.04 ( ~ 0.32- 3.33) Ekcluded/Trnnd 38 1 t50 0.97 0.90 ~ 0.90 : 0.97 0.95 POPULATION BASED STUDIES Non axpos.d 294 718 1.00 1.00 1.00 ( 1.00 1.00 q<OSCU<5 72 182 1.22 ( 0.83- 1.80) 1.18 ( 0.79- 1.77) 1.12 ( 0.66- 1,91) 1.23 ( 0.83- 1.82) 1.03 ( 0.65- 1.64) a<OSCU<12 6 32 0.52 ( 0.20- 1.31) 0.55 ( 0.21- 1.40) 0.73 ( 0.23- 2.31) 0.44 ( 0.16. 1.20) 0.63 j 0.23- 1.68) 12<OSCU ° 20 1.02 ( 0.35- 2.95) 1.09 ( 0.37- 3.19) 1.12 ( 0.29- 4.40) 1.05 ( 0.36- 3.03) 0.96 ( 0.22- 4.14) Excluded/Tnnd 1 18 ~ 0.41 0.42 0.48 ~ 0.43 0.40 NOSPITAL BASED STUDIES Non •xposotl 179 q<0SCU<5 31 8<OSCU<12 11 12<OSCU 7 fxc1udid/Trand 18 WiTHOUT OCCASIONAL SMOKERS Non axposad 3141 1.00 75 0.72 ( 0.43- 1.21) 20 0.87 ( 0.38- 1.97) 13 0.87 ( 0.32. 2.37) 0 0.85 fxcludad/Trand~ 131 12 AGE <55 YEARS Non exposetl 115 225 1.00 t.00 1.00 1.0o t.oo 0<OSCU<S 32 90 0.65 ( 0.37- 1.14) 0.71 ( 0.39- 1.28) 0.78 ( 0.36- 7.67)~ 0.68 ( 0.38- 1.19) 0.67 ( 0.35• 1.26) S<OSCU<12 8 19 0.80 ( 0.31• 2.07) 0.66 ( 0.21- 2.02) 0.48 ( 0.09- 2.46) 0.65 ( 0.24. 1.78) 0.71 ( 0.25- 2.06) 12<OSCU 4 14 0.61 ( 0.17• 2.12) 1.05 { 0.28- 3.91) 1.12 ( 0.23- 5.44) 0.76 ( 0.21- 2.68) 0.64 { 2.85) 0.15- fXCltKftd/TrOnd 6 73 0.54 ; 0 .53 0.53 0.52 ~ 0.52 AGE 55•64 YEARS 1.00 j 1.00 0.74 ( 0.43- 1.24) 0.64 ( 0.36- 1.13) 0.93 ( 0.40- 2.16) 0.87 ( 0.34- 2.21) 1.06 ( 0.38- 2.91) 0.73 ( 0.23- 2.35) 0.86 ( 0.76 Non exposed 148 383 1.00 1 .00 t.oo 1.00 1•00 O<OSCU<'~ 39 80 1.78 ( 1.Oa• 3.04) 1.84 { 1.05- 3.23) 1.33 ( 0.67- 2.68) 1.78 ( 1.03- 3.07) 1.54 { 0.81- 2.92) 5<OSCUc13 ~ 4 15 0.70 ( 0.21• 2.35) 0.61 ( 0.16- 2.33) 1.16 ( 0.27- 5.10) 0.77 ( 0.22• 2.63) 0.63 ( 0.16• 2.52) 12<OSCU 3 8 0.86 ( 0.20• 3.73) 0.36 ( 0.04- 3.19) 0.00 ( 0.00-99.99) 0.88 ( 0.20- 3.86) 0.63 f 0.06- 6.33) rxcludod/Trendj 1s 1 6s 0.49 0.50 ~ 0.55 [ 0.51 - 0.49 xpos0tl 210 424 1,00 1.00 1.00 1.00 1.00 ( 0<OSCU<S 32 67 0.91 ( 0.52- 1.58) 0.98 ( 0.55- 1.72) 1.25 ( 0.56- 2.80) 0.93 ( 0.53• 1.62) 0.60 ( 0.32- 1.13) G<OSCU<12 5 18 0.66 ( 0.22- 1.93)1 0.86 ( 0.29- 2.60) 1.18 ( 0.33- 4.17)i 0.70 ( 0.24- 2.09} 0.81 ( 0.25- 2.64) 12<OSGU 1 5 11 1.37 ( 0.42- 4.46)/ 1.67 ( 0.50- 5.56)1 3.30 ( 0.64-17.12) 1.41 ( 0.43- 4.59) 1.09 ( 0•27• 4.44) EXC1lIdOd/Tl•Qnd E 29 F09 0.93 i 0.90 ( 0.93 ~ 0.92 0.96 • D DIAGNOSIS HISTOLOGICALLY CONFIRM 0%pos9tl 460 Non 0<OSCU<S 100 $<OSCU<.12 72<OSCU ~ 16 12 Excl~nJod/Trind 39 SQUAMOUS CELL CARCINOMA 1032 1.00 1.00 1.00 1.00 1.00 237 1.00 ( 0,73- 1.36) 1.09 ( 0.76• 1.51) 1.11 ( 0.73• 1.70) 1.02 ( 0.75• 1.4C) 0.85 ( 0.59- ',.21) 52 0.66 ( 0.36- 1.23) 0.66 ( 0.33• 1.30) 0.84 ( 0.38- 1.88) 0.65 { 0.34• 1.22)~ 0.75 ( 0.38- 1.47) 33 0.94 ( 0.45- 1.95) 1.09 ( 0.50- 2.40) t.16 ( 0.41- 3.24) 1.06 ( 0.51- 2.21j! 0.83 ( 0.33- 2.05) 788 0.42 0.42 0.45 ` 0.44 I 0.39 Non oxposfo 77 1032 t.o0 1.00 1.00 1.00 7.00 0<OSCU<$ 17 237 1,68 ( , 0.87• 3.23) 1.71 ( 0.85- 3.45) 1.37 ( 0.53- 3•56)I 1.76 ( 0.9t- 3.41) 1.a1 ( 0.65• 3.07) 6<OSCU<.12 4 52 1,46 ( 0.47- 4.53) 1.67 ( 0.47- 5.93) 2.33 ( 0.61- 8.91)~ 1.51 ( 0.47- 4.79) 1.88 ( 0.52- 6.86) 12<OSCU 3 33 2.07 ( 0.55- 7.77) 2.94 ( 0.77-11.17) 6.61 ( 7.36-32.15)I 2.64 ( 0.71- 9.78) 2.29 ( 0.44-12.09) fxCludsd/Trlnd 8 188 0,30 0.31 0.31 i 0.31 ~ 0.32 SMALL CELL CARCINOMA Non Qxposeo 53 1032 1.00 7.00 1,00 1.00 ' 1.00 0<OSCU<5 5 237 0.74 ( 0.27- 2.03) 0.60 ( 0.19- 1.84) 0•39 ( 0.09- 1.74) 0.74 ( 0.26- 2.06) 0.63 ( 0.20• 1.94) $<OSCU<12 4 52 3.06 ( 0,93-10,12) 2.95 ( 0.87• 9.98) 3.63 ( 0,98-13.47) 2.07 ( 0.54- 7.92) 3.39 ( 0.98•11.72 ) ~ 0 72<OSCU I 33 i 0.00 ( 0.00-99.99) 0.00 ( 0.00•99.99) 0.00 ( 0.00-99.99) 0.00 ( 0.00-99.99) 0.00 ( 0.00-99.99) 8 7 88 0.44 0.46 0.48 0.46 0.44 Non exposatl 245 1032 1.00 1.00 1.00 1.00 1.00 0<OSCU<5 57 237 0.91 ( 0.62- 1.34) 1.02 ( 0.68• 1.53) 1.06 ( 0.62- 1.81) 0.94 ( 0.63- 1.40) 0.79 ( 0.51- 1.22) ~<OSCU<12 6 52 0.40 ( 0.16- 1.00) 0.25 ( 0.07• 0.85) 0.32 ( 0.07- 1.41) 0.43 ( 0.17- 5.08) 0.41 ( 0.15- 1.10) 12<OSCU 9 33f 1.24 ( 0.54- 2.83) 1.39 ( 0.55- 3.48) 1.01 ( 0.26- 3.92) 1.45 ( 0.63- 3.30) 1.04 ( 0.38- 2.89) Excluded/Trtnd I 76 188' 0.63 0.59 I o•s2 ' 0.66 E 0.58 OTHER Non exposeo € a5 1032 1.00 1.00 1.00 1.00 1.00 0<OSCU<5 ( 21 237 0.85 ( 0,47- 1.53) 1.05 ( 0.57- 1.92) 1.28 ( 0.61- 2.68) 0.85 ( 0.47- ?.54) 0.76 ( 0•39- 1.47) 5<08CU<12 f 2 52 0.34 ( 0,08• 1.48) 0.45 { 0.10• 2.00) 0.00 ( O,OD-99.99) 0.35 ( 0.08• 1.56 ) 0.43 ( 0.10• 1.94) 12<OSCU ~ 0 33 0.00 ( 0• 00-99.99) 0.00 ( ~ 0.00•99.99) 0.00 ( 0.00-99.99) 0.00 ( 0.00-99.99) 0.00 ( 0.00-99.99) fxcludad/Trond ?~ 788 0.04 0.04 0.04 ~ 0.04 0.04 >7544 OF LlFESPAN IN RURAL AREA OR INTERMEDIATE CITIES Non exposed 186 332 1.00 1.00 1.00 1.00 1.00 0<OSCU<5 35 90 0.81 { 0•48• 1 .36) 0.81 ( 0.48- 1.38) 0.88 ( 0.44- i.77) 0•82 ( 0.48- 1.40) 0.73 ( 0.41- i.28) 5<OSCU<12 7 20 0.74 ( 0.29• 1.90) 0.74 ( 0.29- 1.90) 0.69 ( 0.23- 2.09) 0.56 ( 0,20- 1.53) 0.61 { 0.22- 1.67j 12<OSCU 3 10 0.58 ( 0.15- 2.27) 0.58 ( 0.15• 2.27) 0.94 ( 0.15- 6.07) 0.57 ( 0.14- 2.25) 0.56 ( 0.14- 2.33) fxcluded/Trend 25 123 0.38 ~ 0.38 ( 0.37 0.31 0.32 375x OF LIFESPAN IN URBAN AREA Non •xp05ltl 171 513 1.00 1.00 1.00 1.00 1.00 0<OSCU<5 52 114 1.42 ( 0.90- 2.24) 1.42 ( 0.90- 2.24) 1.41 ( 0.79- 2.51) 1.42 ( 0,89- 2.25) 1•24 { 0.70- 2.16 ) 5<OSCU<.12 5 23( 0.77 ( 0•27- 2.24) 0.77 ( 0.27- 2.24) 0.80 ( 0.21- 3.10) 0.88 (, 0.29- 2.51) 1.32 ( 0.41- 4.31) 12<OSCU 5 14 1.83 ( 0.59• 5.66) 1.83 ( 0.59- 5.66) 1.10 ( 0.20• 5.90) 1 1.94 ( 0.62- 6.05) 3.77 ( 0.72-19.66) fxcl udtd/Tnnd 1T! 1 47 0.62 0.62 0.61 0•56 1 0.65 (1) Model includa sex, eenter, zex•center and age (2) Model Inofudo sex, center, sex'center, age and proporttion of residential type in the last 35 yrs (REUP) (3) Model Indudo sex, center, sex'center, age, proportion of residential type in the last 35 yrs (REUP) and educational level (EDUC) ,r4) Modc' lndudv sex, ccnfc , sex'eenter, ape and duratlen ~ expesure fo list A agenes (OCLAY) (5) Model include sox, center, sex'center, age and frequency consumption of vegetables (VEGE) Risk estimates - Occasional smoking

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C _C1 WD Childhood 0-18 yrs, Weighted duration (years) ALLCENTERS Lwe1 of expoaurn Cas es Contr ols I OR(1) 95% C1 Non exposed 252 496 1.00 0<C1YW<19 274 638 0.83 ( 0.66- 1.04) 19<C1riD<28 90 279 0.73 ( 0.54- 0.99) 26<C1YfD 25 104 0.59 ( 0.36- 0.97) Excludtd/Tr®nd 9 25 0.01 ALL CENTSR$ W1TH EDUCATIONAL LEVEL AND TYPE OF RESIDENCE OR(2) 1.00 0.88 (, 0.69- 1.12) 0.78 ( 0.56- 1.08) 0.59 ( 0.35- 1.00) 0.01 OR(3) 95% C/ ) OR(4) 95% CI 1.00 1.00 0.84 ( 0.64- i.10)1 0.83 ( 0.66- 1.05) 0.81 ( 0.55- 7.20)~ 0.74 ( 0.54- 1.01) 0.56 ( 0.30- 1.04) 0.60 ( 0.36- 0.99) 0.01 0.01 OR(5) 95% Ct ( 1.00 0.79 ( 0.62- 1.02) 0.75 ( 0.52• 1.08) 0.59 ( 0.33- 1.08) 0.01 Non exposed 149 350 1.00 1.00 1.00 1.00 1.00 ( 0<C1W0<19 201 504 0.85 ( 0.65- 1.11) 0.85 ( 0.65- 1.12)1 0.84 ( 0.64- 1.10) 0.85 ( 0.64- 1.12) 0.83 ( 0.62• 1.10) 1g<CfliD<-26 59 205 0.82 ( 0.56- 1.20) 0.83 ( 0.56- 1.21) 0.81 ( 0.55- 1.20) 0.85 ( 0.58- 1.26) 0.86 ( 0.55- ~ 1.34) 26<C1Y10 15 80 0.59 ( 0.32- 1.09) 0.59 ~ ( 0.32- 1.09) 0.56 ( 0.30- 1.04) 0.56 ( 0.30- 1.06) 0.64 ( 0.31- 1.30) dxcludid/Trendf 74 199 0.01 0.01 EE 0.01 0.01 0.01 1 ALL CENTERS WITH DIETARY DATA Non expos.d 169! 320 1.00 1.00 1.00 1.00 1.00 0<C1WD<e10 225 ' 494 0.79 ( 0.61- 1.01) 0.83 ( 0.64- 1.07) 0.81 ( 0.61- 1.09) 0.80 l, 0.62- 1.03) 0.79 ( 0.62- 1.02) 19<C1WD<.26 64 153 0.75 ( 0.52• 1.08) 0.80 ( 0.54- 1.17) 0.88 ( 0.56- 1.38) 0.74 ( 0.51- 1.08) 0.75 ( 0.52- 1.08) 26<Ct1YD 17 59 0.58 ( 0.32- 1.05) 0.59 ( 0.32- 1.09)~ 0.60 ( 0.30- 1.23) 0.59 ( 0.33- 1.07) 0.59 ( 0.33. 1.08) ~cluded/Trand 14 30 0.01 0.01 t 0.01 0.01 0.01 FRANCE Non exposed 0<C1Y~<19 19<C1Yt0<26 26<CiWD Exc1 udad/Trend GERMANYI Non exposed 0<C1W0<19 19<C1P(D<26 26<C1Yt0 fxcludrd/Trsnd GERMANY2 32 37 1.00 1.00 1.00 1.00 1.00 23 62 0.45 (, 0.23- 0.89) 0.72 ( 0.33- 1.56) 1.01 ( 0.35- 2.90) 0.44 ( 0.22- 0.88) 0.46 ( 0.23. 0.91) 19 43 0.51 ( 0.24- 1.05) 0.76 ( 0.33- 1.72) 1.33 ( 0.46- 3.88) 0.50 ( 0.24- 1.05) 0.51 ( 0.25- 1.06) 2 9 0.24 ( 0.05- 1.22) 0.20 ( 0.02- 1.72) 0.72 ( 0.07- 7.74) 0.23 ( 0.05- 1.18) 0.24 ( 0.05- 1.21) ? 0 0.02 , 0.02 0.02 ~ 0.02 0.02 29 74 1.00 1.00 1.00 1.00 1.00 37 115 0.61 ( 0.33• f.14) 0.64 { 0.32- 1.27) 0.62 ( 0.31- 1.24) 0.66 ( 0.35- 1.24) 0.65 ( 0.34- 1.23) 7 32 0.55 ( 0.21- 1.46) 0.67 ( 0.24- 1.88) 0.74 ( 0.26- 2.14) 0.58 ( 0.22- 1.57) 0.60 ( 0.22- 1.64) ~ 1 5 0.39 ( 0.04- 3.98) 0.59 ( 0.05• 6.56) 0.65 ( 0.06- 7.48) 0.44 ( 0.04- 4.59) 0.47 ( 0.04- 3.88) 2 3 0.09 0108 0.11 0.10 0.13 oxposoq Non 2 63 1.00 1.00 1.00 1.00 1.00 ! 0<C1WD<•1D 68 93 0.74 1 0.46- 1.22) 0.75 ( 0.46- 1.23) 0.73 ( 0.44- 1.22) 0.74 ( 0.45 - 1.21) 0.75 ( 0.46• t.22) 9<C t VYO<26 1 7 4 1.59 ( 0.43- 5.95) 2.01 ( 0.51- 7.97) 2.15 ( 0.52- 8.80) 1.58 ( 0.42- 5.89) ~ 1.62 ( 0.43- 6.08) 26<C1WD 4 1 5.66 ( 0.58-55.38) 5.06 ( 0.51-50.27) 4.41 ( 0.42-45.79)1 5.87 f, 0.58-58.97) 5.68 ( 0.58-55.61) EXCludid/Trsnd ? 2 0.71 1 0.68 0.77 0.72 0.70 ( GERMANY3 Non expoaea 15 18 1.00 1 1.00 1 1.00 1.00 1.00 0<C1YfD<t9 14 330.54 ( 1 0.19• 1.57) 0.52 ( 1 0.18- 1.54) 0.51 ( 0.16- 1.59)1 0.67 ( 0.22- 2.04) 0.44 ( 0.14- 1.35) 19<C1SV0<26 ~ 9 9.99 ( 0 0.00•99.99) 99.99 ( 0.00-99.99j 99.99 ( 0.00-99.99)99.99 (, 0.00-99.99) 99.99 ( 0.00-99.99) Excludad/Trend r 1j 0.39 f 0.38 0.37 1 0.43 0.28 I ITALY I Non exposod 0<C1W0<19 19<C1WD<26 26<C1WD Excluded/Trend ITALY 2 11 49 1.00 i 1.0o t.oo 11 00 18 70 1.07 ( 0.44- 2.57)I 1,37 ( 0.52- 3.57) 1.30 ( 0.48- 3.50) 1.09 ( 0.43- 2.72) ' 7 68 0.33 ( 0.11- f 0.96) 0.46 ( 0.15- 1.4 6) 0.49 ( 0.15- 1.59) 0.37 ( 0.12• 1.12) 1 [ 2 24 0.27 ( 0.05- I 1.38) 0.39 ( !!! 0.07- 2.10) 0.40 ( 0.07- 2.23) 0.15 ( 0.02- 1.28) ~ I 2 10 0.02 ~ 0.07 1 0.07 + 0.02 t Non Qxposen 1 6 77 1.00 1.00 1.00 1.00 0<C1VW <•19 2 40 0.80 ( 0.15• 4.37) 1.34 ( 0.21- 8.47) 0.58 ( 0.05- 6.57)~ 0.89 ( 0.16- 4.94) 19<C1WD<26 ~ 1 9 38 3.53 ( 1.06•11.81) 7.18 ( 1.62-31.77) 2.95 ( 0.55- 15.85) 3.78 ( 1.11• 12.81) 26<C1W0 1 2 16 1.97 ( ~ 0.32-11.99) 2.69 ( 0.27-27.14) 1.07 ( 0.08- 14.60) 2.14 ( 0.34- 13.26) fxcludid/Trendl 0 2 0.13 0.05 t a 11 ~ 0.11 ) ITALY 3 Non expo3etl 19 1.00 1.00 t 1.00 1.00 1.00 0<C1YtD<19 4 10 0.70 ( 0.14- 3.45) 0.61 ( 0.12- 3.25) 0.40 ( 0.06- Z 56) 0.76 ( 0.15• 3.81) 0.77 ( 0.12• 4.87) I 19<C1W0<26 ' 5 17( 0.77 ( 0.18• 3.37) 0.70 ( 0.14- 3.59) 0.41 ( 0.07- 2.52) 0.53 ( 0.11- 2.66) 0.73 ( 0.13- 3.98) I 26<C1WD Illl 0 - 4 0.00 ( 0.00-99.99) 0.00 ( 0.00-99.99) 0.14 ( 0.00-99.99) 0.00 ( 0.00-99.99) 0.00 ( 0.00-99.99) 6xcluded/rrsndl 0 0 ~ 0.21 0.21 0.39 0.13 0.21 PORTUGALI Non exposeo 2• 15 00 1.00 0<C1YfD<19 15 12 0.85 ( 0,30- 2.45) ~ ~ 0.85 ( 0.29• 2.47) 19<C1YN<•26 7 7 0.58 ( 0.16- 2.12) 0.51 ( 0.13- 1.92) I 28<C1ND 3( 2 0.94 ( 0.13- 6.61) ~ i 2.18 ( 0.19•24.87) € 0'xcluded/Trend 01 3 0.62 )t 0.58 ffit PORTUGAL 2 Non expofed 17 26 1.00 1.00 0<C11~<19 ' 12 17 1.11 (, 0.41- 3.06) 0.93 ( 0.30• 2.93) 1.02 ( 0.36- 2.89) 19<C1'flDu26 ~ 3 8 0.62 ( 0.14- 2.80) 0.25 ( 0.04• 1.48) 0.61 ( 0.14- 2.79) ! 26<C1Y/D t 1 2 ' 0.85 ( 0.06-11.29) 1.03 ( 0.06- 14.15) ~ 0.95 ( 0.07- 12.66 ) 1 1! E"xcl udad/Trend l 0 0 tttf 0.73 0.72 0.68 1 1 SPAIN Non e%pOSOtl 13 32 1.00 1.00 1.00 1.00 1.00 O<C1W0<19 37 75 1.18 ( 0.55• 2.55) 0.98 ( 0.44• 2.16) 1.09 ( 0.47- 2.52), 1.15 ( 0.53- 2.50)~ 1.17 ( 0.54- 2.55) <•26 19<C1W0 14 34 ~ 1.02 ( 0.40• 2.56) ( 0.80 ( 0.30- 2.12) 0.89 ( 0.32- 2.42) I 1.04 ( 0.41- 2.64) I 1.00 ( 0.39• 2.56) 2B<C11YD ~ 5 14 0.76 ( 0.22- 2.62) 0.66 ( 0.19- 2.32) 0.72 ( 0.20- 2.62)I 0.72 ( 0.21- 2 53) I 0.87 l, 0.25- 3.07) 5XC1 uded/Trend l€ 2 I 4 ' ! 0.66 ~ 0.67 0.75 1 0.65 tl 0.80 SWEDEN txp030tl Non 29 45 1.00 1.00 1.00 1. 00 ! 0<C11W< 19 19 27 38 1.07 ( 0.53• 2.16) 1.01 ( 0.50- 2.06) 1.04 ( 0.52• 2.10) 1.01 ( 0.50- 2.05) 19<C1YN< 26 10 21 0.72 ( 0.29• 1.80) 0.67 ( 0.27- 1.69 ) 0.66 ( 0.26- 1.68) 0.63 ( 0.25- 1.60) 26<C1Y(D 4 8 0.88 ( 0.24- 3.24) 0.90 { 0.24- 3.34) 0.89 { 0.24- 3.27) t.OS ( 0.28- 3.97) bxcluded/Trend 0 0 0.66 0.60 i 0.60 0.67 UNITED KINGDOM Non exposed 7 41 t.0o 1.00 1.00 t.oo 1.00 0<C1YfD<i9 17 73 1.32 ( 0.50• 3.50) 1.22 ( 0.45- 3.30) 1.15 ( 0.42• 3.13) 1.12 ( 0.41- 3.02) 1.45 ( 0.54- 3.90) ~ 1fl<C1YfD<26 1 7 0.86 ( 0.09- 8.71) 0.84 ( 0.08- 8.63) 0.85 ( 0.08- 8.71) 0.82 ( o.os- s.4a) 0.99 ( 0.10-10.11) 26<C1Y(D 1 19 0.20 ( 0.02- 2.29) 0.14 ( 0.01- 1.93)1 0.12 ( 0.01- 1.72) 0.19 ( 0.02- z.2s) 0.19 ( 0.02- 2.24) Excluded/TrCndl 0 0~ 0.23 0.18 1 0.14 0.20 ~ 0.23 (1) Modci indudo sex, t:anter, sex'center and age (2) Model kxk~de sex, center, sox'oenter, age and proportion of residential type in the last 35 yrs (REUP) (3) Modei trxlude aex, center, atx'center, age, proportion of residentiai type in the last 35 yrs (REUP) and educational level (EDUC) {1J h(pQ¢r t(iGft(d¢ Q¢K, GQrt(ar; ~ex Gentar, eqc and dvratron of exposure to list A acvents (OCLAY) (5) Model Indudo sex, center, sox'oonter, age and frequency consumption of vegetables (VEGE) '~ - 206359332? Risk estimates - Childhood 0-18 years

Childhood 0-18 yrs, Weighted number of smokers ldEN ONLY Lwel e} o suro Casoa i ConVols O 1 95X CI OR(2 95% Cl { O 3 95% Cl OR 4) 95% Cl 6R 5 95% Cl ~ Non .xpoa.0 ss 201 1.00 1.00 1•00 1.00 - E 1.00 0<G1MM<0.75 58 231 0.86 ( 0.55- 9.35) 1.01 ( 0.62• 1.64) 0.77 ( 0.43- 1.39) 0.89 ( 0.57- 1.40) 0.85 ( 0.51- 1.42) 0.75<CiYM<1.00 9 49 0.61 ( 0.25- 9.50) 0.57 ( 0.20- 1.63) 0.44 ( 0.13- 1.48) 0.57 ( 0.22- 1.43) 0.20 ( 0.04- 0.93) 1.00<C1WN 8 41 0.59 ( 0.24- 1.44) 0.78 ( 0.31- 1.95) 0.80 ( 0.24• 2.62) 0.68 { 0.28- 1.67) 0.80 ( 0.30- 2.10) €xcluded/Trend 71 9 0.17 0.17 ( 0.17 0.78 0.17 WOMEN ONLY Non lxposed 187 295 1.00 1.00 1.00 1•00 1•00 0<C115N<0.76 238 535 0.74 ( 0.58- 0.96) 0.79 ( 0.60- 5.03) 0.82 ( 0.60- 1.11) 0.75 (, 0.58- 0.96) 0.74 ( 0.55• 0.98)1 0.76<C10<1.00 39 82 0.85 ( 0.55. 1.33) 0.80 ( 0.50. 1.28) 0.76 ( 0.44- 1.30) 0.84 ( 0.53- 1.31)~ 0.99 ( 0.58- 1.67)! 1.00<C1Wl1 ~ 37 83 0.92 ( 0.59- 1.45) 0.90 ( 0.56- t.45)~ 0.93 ( 0.55- 1.68) 0.92 ( 0.58- 1.46)I 0.83 ( 0.49- 1.42)~ EXCldded/Trend 8 16 0.60 0.59 0.48 0.59 ~ 0•65 POPULA110N BASED STUDIES Non oxposed tsz 326 1.00 1.00 1.00 1.00 1.00 0<C1WN<0.75 168 ! 440 0.79 { 0.60- 1.06) 0.84 ( 0.63- 1.12) 0.76 ( 0.54• 1,06) 0.83 ( 0.62- 1.11) 0.76 ( 0.55- 1.05) 0.76<CiMAI<1.OU 21 90 0.63 ( 0.36- 1.10) 0.69 ( 0.39• 1.20) 0•49 ( 0.25- 0,95) 0.64 ( 0.37- 1.11) 0.68 ( 0.36- 1.31) 1.00<C1YrN 31 76 ~ 0.96 ( 0.56- i.59) 1.06 ( 0.64- 7.78) 1.14 ( 0.62- 2.08) 0.98 ( 0.59- 1.63) 0.98 ( 0.53- 1.81) cskcluded/Trend 6 18 0.62 0.61 0.52 0.65 0.62 HOSPITAL BASED STUDIES Non !%pOSatl 93 129 1.00 1.00 1.00 1.00 1.00 0<C11VN<0.7b 114 258 0.67 ( 0.46• 0.97) 0.73 ( 0.48- 1.12) 0.82 ( 0.48- 1.41) 0.64 ( 0.44- 0.92) 0.66 ( 0.42- 1.03) 0.76<C1wN<1.00 ' 24 33 0.89 ( 0.48- 1.65) 0.67 ( 0.31• 1.42) 0.92 ( 0.39- 2.18) 0.86 j 0.46- 1.61) 0.68 ( 0.31- 1.52) 1. 00 <C 1 VYN 12 25 0.71 ( 0.33- 1.53) 0.66 (, 0.28- 1.57) 0.97 ( 0.36- 2.59) 0.75 (-0.35- 1.62) 0.73 ( 0.31- 1.70) Ezcluded/Trand 3 7 0.29 0.27 I 0.30 0.26 0.34 WITHOUT OCCASIONAL SMOKERS axpo:oa Non t6t 364 1.00 1.00 1.00 5.00. 1.00 0<CiWN<0.78 230 546 0.88 ( 0.68• 1.14) 0.95 ( 0.72- 1.25) 0.91 ( 0.67- 1.24) 0.91 ( 0.70- 1.19) 0.84 ( 0.63- 1.13) 0.75<C1WT1<1.00 36 99 0.80 ( 0.50- 1.27) 0.66 ( 0.41- 1.15) 0.63 ( 0.35- 1.11) 0.79 ( 0.49- 1.26) 0.65 ( 0.36- 1.16) 1.00<C1M'N 33 78 1.14 ( 0.70- 1.86) 1.22 ( 0.73- 2.02) 1.16 ( 0.67- 1.99) 1.15 ( 0.70- 1.90) 1.18 ( 0-66- 2.12) Ezcludad/Trand 6 17 0.82 0.82 0.74 0.85 0.89 AGE <55 YEARS Non QxpOSltl 67 114 1.00 1.00 : 1.00 1.00 1.00 ' 0<C1YM<0 ,76 67 ':70 0.64 ( 0.41• 1.01) 0.85 ( 0.51• 1.40)1 1.04 ( 0.56- 1.94) 0.62 ( 0.39- 0.99) 0.60 ( 0.36- 1.02) ~ 0.76<C1W'N<1.00 13 33 0.83 { 0.38• 1.81) 0.91 ( 0.38- 2.18)j 0.94 ( 0.35- 2.57) 0,81 { 0.37- 1•79) 0.73 ( 0.28- 1.90) ° .00<C1WN 17 40 0.85 ( 0.42- 1.74) 1.16 ( 0.53- 2.51) 1.38 ( 0.54- 3.52) 0.85 ( 0.41- 1.76) 0.99 ( 0.43- 2.24) EXCludid/Trendi 1 41 0.31 0.30 ~ 0.29 ~ 0.27 ~ 0.30 AGE 55-64 YEARS Non oxposatl 76 176 1.00 1.00 1.00 1.00 1.00 0<C1YM<0.75 101 274 0.84 ( 0.57- 1.24) 0.83 ( 0.55- 1.25) 0.79 ( 0.49- 1.27) 0.81 ( 0.54- 5.20) 0.74 { 0.47- 1.16) 0,75:CiWN<1.00 18 48 0.79 ( 0.41. 1.53) 0.66 ( 0.32- 1.35) 0.59 ( 0.26- 5.34) 0.72 ( 0.36- 1.41) 0.63 ( 0.27- 1•45) 1 ,00<C1NT! 11~ 41 0.65 ( 0.30- 1•41) 0.59 ( 0,26• 1.32) 0.70 ( 0.30- 1,65) 0.64 ( 0.29- 1.40) 0•50 ( 0.21- 1.23) ~ frcludid/Trend 111 4 73 0.25 0.25 0.19 ~ 0.26 0.26 AGE 65+ YEARS Non lxposotl 1 09 aos 1,00 1.00 1.00 1.00 ; 1.00 0<GiWN<0,75 128 322 0.79 ( 0.56- 1.10) 0.80 ( 0.56- 1.14) 0.70 ( 0.46- 1.07) 0.82 ( 0.58- 1.15)f 0.81 ( 0.56- 1,17) 0.75<C1YIN< 1 . 00 17 50 0.74 ( 0.38- 1.44) 0.76 ( 0•36• 1.52) 0.67 ( 0.30- 7.49) 0.77 ( 0.39- 7.51)i 0.97 { 0.46- 2.07) t.00<C1WN 17 43 1.02 ( 0.52- 1.97) ~ 1.00 ( 0.50- 2.00) 1.04 ( 0.47- 2.31) 1.06 ( I 0.55- 2.07) 0-95 { 0.43- 2.10} Exc1 uded/Tnnd 4 8 0.65 0.66 !!! 0.59 0.65 IIII 0.61 HISTOLOGICALLY CONFIRMED DIAGNOSIS !%pOSetl Non 242 496 1.00 1.00 1.00 1.00 I 1.00 0<G114N<0.75 286 766 0.76 i 0.61- 0.95) 0.83 ( 0.65- t.05) 0.80 ( 0.61- 1.04) 0.77 { 0.62• 0.96)) 0.75 ( 0•58- 0.96) 0,75<C1WN<1.00 47 131 0,82 ( 0.55• 1.22) 0.79 ( 0.51- 1.21) 0.69 ( 0.43- i.13) 0.79 ( 0.53- 1.19)1 0.77 ( 0.48- 1.25) 1.00<C1VYN 43 124 0.81 { 0,54• 1.21) 0.86 (, 0.56- 1.31) 0.89 ( 0.55- 1.45) 0.83 ( 0.55• 1.26) 0.77 ( 0.48- 1.24) €.rc1 udad/Trand 9 1 25 0.25 0.25 0.21 0.26 ~ 0.27 SQUAMOUS CELL CARCINOMA exposed Non 12 496 1.00 1.00 1.00 1.00 1.00 0, ~ 0<C1fSN<75 39( 766 0.47 ( 0.30. 0.74) 0.50 ( 0.31- 0.82) 0.56 1 0.32- 0.97) 0.47 { 0.30• 0.75) 0•49 { 0.29- 0.82 ) 0, 76<C1WN< 1.00 8~ 131 0.62 ( 0.27• 1.40) 0.40 ( 0.14- 1.16) 0.34 ( 0.10- 1,18) 0.53 ( 0.22• 1.25) 0.38 ( 0.11- 1.29) ~ t .00<CiVFN 9 124 0.85 ( 0.39- i,64) 0.87 1.12 ( 0.46- 2.70) 0.81 ( 0.36- ?•82) 0.64 ( 0.24- 1.75) t €zcluded/Trand 7~ 25 0.11 0.11 j 0.08 : 0, 10 0,11 ~ SMALL CELL CARCINOMA Non e%posea ( z8 4ss 1.Oc 1.00 1.00 1.00 1.00 O<C1YfN<0 75 j . 36 766 0.79 ( 0,46• 1.35) 0.79 ( 0.45- 1.37) 0.67 ( 0.38- 1.19) 0.83 ( 0.48- 1.45) 0.67 ( 0.38- 1•17) ,0 (0 0.75<C1WN<1 4 131 0.73 ( 0.24- 2.22) 0.81 ( 0.26• 2.50) 0.54 ( 0.15- 1.93) 0.79 ( 0.26• 2.46) 0.56 ( 0.16• 2.00) I 1,QO<C11S'N 1 124 0.23 ( 0.03- 1.79) 0.24 ( 0.03- 1.88) 0.23 ( 0.03- 1.77) 0.25 ( 0.03- 1.98) 0.23 ( 0.03- 1.82) €xcludad/Trandl 25 0.33 ~ 0.31 ~ 0.27 I 0.37 ~ 0.33 ADENOCARCINOMA Non exposld 0<C1WN<0.75 124 496 t.oo 1.00 1.00 1.00 i 1.00 155 766 0.78 ( 0.59- 1.04)i 0.87 ( 0.64- 1.18) 0.86 ( 0.60- 1.23) 0.79 ( 0.59- 1•05)) 0.76 ( 0.55• 1.05) 0,75<C1WN<1.00 I 24 131 0.84 (, 0.50• 1.40) 0.86 (, 0.50• 1.50) 0.84 ( 0.45- 1.55) 0.81 ( 0.48- 5.37)I 0.88 ( 0.49• 1.60) 1.00<C1WN 25 124 0.91 ( 0.55- 1.52) 0.99 ( 0.58- 1.70) 1.00 ( 0.52- 1.89) 0.97 !, 0.58- 5.62)i 0.84 ( 0.46- 1.52) Excludsd/Trrnd 5 25 0.64 0.64 I 0.60 ~ 0.60 1 0.68 Non CXpOSStl 38 496 1.00 1.00 ( 1.00 1.00 1.00 0<C1VYN<0 .75 56~ 766 0.94 ( 0.60- 1.48) 1•07 ( 0.66- 1.75} 0.98 ( 0.57- 1.70) 0.95 ( 0.60• 1.49) 1.10 ( 0.66- 7.86) 0.76<C1K'N<1.00 11' 131 1.13 ( 0.55- 2.32) 7.06 (, 0.48- 2.37) 0.83 ( 0.32• 2.75) 1.12 ( 0.54- 2.32) 1.20 ( 0.49- 2.94 ) ~ 1 .00<C115'N 8 Ef 124 0.85 ( 0.38- 1.93) 1.02 ( 0.44- 2.37) 1.20 ( 0.48- 3.01) 0.89 ( 0.39- 2.02) 1.42 ( 0.60- 3.38) I udsd/Trend EXC1 ' 2 25 0.98 ~ 0.99 0.99 I 0.97 0.97 >75% OF LIFESPAN IN RURAL AREA OR INTERMEDIATE CITIES Non exposed 113 189 1.00 F1 .00 1.00 { 1.00 1.00 0<C1VrN<0.75 116 299 0.66 ( 0.47• 0.92) 0.66 ( 0.47- 0.92) 0.61 ( 0.41• 0.91) 0.67 ( 0.47- 0.94) 0.65 ( 0.45- 0.94) 1.00 0.7b<CiWN< 14 38 0.75 ( 0.37• 1.51) 0.75 ( 0.37- 5.51) 0.87 ( 0.40- 1.90)1 0.70 ( 0.34- 1.44)1 0.81 ( 0.39- 1.71) 1 .00<CiHkl 9 44 0.40 ( 0.18- 0.89) 0.40 ( 0.18- 0.89) 0.30 ( 0.12- 0.80)I 0.41 ( 0.18- 0.91) 0.42 ( 0.18- 0-94) Excludad~rrend 41 d 0.13 0.13 I 0.13 E 0.12 I 0.13 >75% OF UFESPAN IN URBAI Non exposed 0<011YN<0.75 0:76<01WN<1.00 1.00<C1YrN Excl uded/77•end 1.00 1•00 ': 1.00 ~, 1.00 0.84- 1.78) 1.22 ( 0.84- 1.78) 1.19 ( 0.77- 1.85)] 1.22 ( 0.83- 1.78) 1.18 ( 0.77- 7•81) 0.49• 1.70) 0.91 ( 0.49- 1.70) 0.78 ( 0.37- 1.63)f 0.90 ( 0.48• ~ 1•69) 1.02 ( 0.49- 2.12) 0.63- 2.24) 1.19 ( 0.63- 2.24) 1.53 ( 0.75- 3.15) 1.15 ( 0.60- 2.20) 1.02 ( 0.46- 2.25) ~ 0.61 E 0.61 ~ 0.63 E 0.57 !1) Modei fncUo s®x, nmter, sox'canter and age (2) Modol Indude sox, eontar, sox•cantar, age and proponion of residential type in the last 35 yrs (REUP) (3) Modol Ircludo sex, c©ntK, sox'contor, ogo, proport+on of rasidential type in tt+e last 35 yrs (REUP) and educatwnal level (EDUC) (4) Model axlude sex, eantlr, sox'cantor, age and duration of exposure to list A agents (OCLAY) (5) hfouot 1nUucto sex, oantar, sax-contar, aga and fraquenoy cwnsumption of vegeta6les (VEGE) - qK 2063593318 Risk estimates - Childhood 0-18 years

c_va I r Childhood 0-18 yrs, exposure to different tobacco products VEN ONl.Y LevN of exaosuro Cases Controls OR(1 95% CI O 2 95% CI ' O 3 95•b C( I O . 4 95°G CI O 5 95% C! Non .xposao ss 201 1.00 1.00 1.00 1.00 1.00 Only cigarette 43 182 0.79 ( 0.48- 1.31) 0.88 ( 0.51- 1.53) 0.79 ( 0.41- 1.54) 0.81 ( 0.49- 1.35) 0.76 ( 0.41- 1,40) Never cigarette 21 80 0.90 ( 0,48- 1.67) 1.18 ( 0.62- 2.26) 0.76 ( 0.34• 1.68) 0.94 ( 0.50- 1,76)' 0.87 ( 0,45- 1,70) + other cigarette 8 49 0.54 ( 0.23- 9.30) 0.68 ( 0.27- 1.67) 0.43 ( 0.11- 5.65) 0.57 { 0.24- 1.37) j 0.51 ( 0.20- 1.34) c'xcludid/Trand 4 18 ( EEEEEE WOMEN ONLY Non axpasea 187 295 1.00 1,00 1.00 1 1,00 1.00 Only cigarette 186 395 0.78 ( 0.59- 1.03) 0.79 ( 0.59- 5.07) ~ 0.85 ( 0.60- 1.21) 0.79 ( 0.60- 1.04) 0.75 ( 0.54- 1.03) Never cigarette 71 125 0.75 ( 0.52- 1.09) 0.81 ( 0.55- i.19) 0.82 { 0.53• 1.26) 0.76 ( 0.52- 1.11) 0.78 ( 0.53- 1.17) Cigarett0 + other 34 91 0.58 ( 0.37- 0.92) 0.63 ( 0.39- 1.00)~ 0.57 ( 0.33- 0.97) 0.56 ( 0.35- 0.90) 0.55 ( 0.33- 0.93) Ercludad/Trend s9 105 ' E POPULATtON BASED STUDIES Non exposed 752 326 1.00 1.00 1.00 1.00 1.00 Only cigarette 99 309 0.81 ( 0.59- 1.73) 0.85 { 0.60- 1.19) 0.83 (, 0.56- 1.22) 0.87 ( 0.62- 5.21) 0.77 ( 0.52- 1.13) Never cigarette 81 183 0.81 ( 0.57- 1.16) 0.88 ( 0.61- 1.26) 0.73 ( 0.48- 1.09) 0.84 ( 0.58• 1.20) 0.83 ( 0.57- 1.20) Ciqarettm + other 37 114 0.85 ( 0.42• 1.03) 0.71 ( 0.45- 1.12) 0.58 ( 0.34• 1.00) 0.66 ( 0.42- 1.04) 0.62 ( 0.37- 1.04) Excluded/Trsnd 9 15 ( HOSPITAL BJ18ED STUDIES eXpOfmtl Non Only cigarette Never cigarette CiqarOttf + other 93 129 1.00 1.00 1.00 1.00 1.00 132 268 0.71 ( 0.50. 1.02) 0.73 ( 0.48- 1,12) 0,85 ( o.4s- 1.45) o.6a ( 0.47. 0.98) O.ss ( 0.44- 1•07) 11 22 0.79 ( 0.36- 1.74) 1,00 ( 0.42- 2.37) 1.27 { (,47• 3.49) 0.83 ( 0.37- 1.85) 0.80 { 0.34- 1.88) 6 26 0.32 ( 0.12- 0.87) 0.34 ( 0.12- 0.96) 0.44 ( 0.14- 1.46) 0.27 0.81) 0.35 ( 0.12- 1.00) Excludad/Trand( 5 ( ) YlITHOUT OCCASIONAL SMOKERS Non exposed Only cigarette Never cigarette Cigarette + other 181 364 1.00 1.00 1•00 1.00 1.00 185 417 0.94 ( 0.71- 1.25) 0.98 f, 0.72- 1.33) 0.97 ( 0.69- 1.38) 0.97 ( 0.73- 1.29) 0.90 { 0.65- 1.26) 68 158 0.77 ( 0.53- 1.12) 0.84 ( 0.57- 1.23) 0.78 ( 0.52- 1.19) 0.79 ( 0.54- 1.15) 0.74 ( 0.50- 1,10) 30! 99 0.63 ( 0.39- 1.03) 0.70 ( 0,43- 1.15) 0.63 ( 0.37• 1.07) 0.64 ( 0.39- 1.05) 0.55 ( 0.31- 0,96) Excludld/Trand 22 ( ' 6S ! ( 1 E ) AGE <55 YEARS Non eXposetl ' 57 114 1.00 ~ 1.00 ~ 1.00 1.00 ~.00 Only cigarette 73 182 0.73 ( 0.47- 1.14)1 0.96 ( 0.58- 1-60 1.23 ( 0.65- 2.33) 0-72 ( 0.45- 1•13)0.73 ( 0.43- 1•25) Never cigarette ~ 13 26 0.66 ( 0.30- 1.45)1 0.98 ( 0.42• 2.26)~ 0.81 ( 0.31• 2.12) 0.67 ( 0.30- 1.48)I 0.67 ( 0.30• 1.51) Cigarette + other 9 33 0.46 ( 0.20- 1.08) 0.57 ( 0.24- 1.38) 0.76 ( 0.27- 2.14)1 0.40 ( 0.16- 0.98) l 0.38 ( 0.15- 1,00)1 Excluded/Trand ~ 3 6 E € i AGE 65-64 YEARS € Non eXpOfetl 76 176 1,00 1,00 1•00 ,00 1 1.00 Only cigarette 69 201 0,72 ( 0,46• 1.12) 0.68 ( 0.42- 1.10) 0.73 ( 0.42- 9.29) 0.71 ( 0.45- 1.10) 0.57 ( 0.33- 0.98) Never cigarette 34 69 1.13 ( 0.65- 1.98) 1.13 ( 0.64- 1.99) 0.96 ( 0.51- 1.81) 1•08 ( 0.61- 1.90) 1.00 ( 0.54- 1.85) Cigarette + other 17 50 0.68 ( 0.35• 1.32) 0,69 ( 0.35- 1.35) 0.60 ( 0.28- 1.31)~ 0.69 ( 0.35- 1.36) 0.60 ( 0.28- 1.26) Excluded/Trend 14 56 AGE 65+ YEARS Non eXposotl 109 206 1. 00 1•00 T 1•00 1.00 1.00 only cigarette 89 194 0•9 ( 8 0.60• 1.31) 0.88 ( 0.58- 1.33) 0.74 ( 0.45- 1.21) 0.92 ( 0.62- 1.37) 0.90 ( 0•58- 1.42) Never cigarette 45 110 0,66 ( 0.41- 1.05) 0.68 ( 0.42- 1.10) 0.65 ( 0.37- 1.15) 0.70 ( 0,44- 1.12) 0.70 ( 0.42• 1-1s) Cigarette + other 16 57 0.56 ( 0.29- 1.08) 0.60 ( 0.31- 1.17) 0.42 ( 0.19- 0.96) 0.55 ( 0.28• 1.08) 0.57 ( 0.26- 1•21) Excluded/Trend 16 62 HISTOLOGICALLY CONFIRMED DIAGNOSIS Non exposeo 242 496 1.00 1.00 1.00 1.00 1.00 Only cigarette 223 577 0.79 ( 0,62• 1.01) 0.84 ( 0.64- 1.09) 0.85 ( 0.62- 1.16) 0.80 ( 0.62- 1-02) 0.75 ( 0.57- 1.00) Never cigarette f 92 205 0.80 ( 0.58- 1.10) 0.89 ( 0.64- 1.24) 0.80 ( 0.55- 1.17) 0.82 ( 0.59- 1.13) 0.81 ( 0.58- 1.14) ~ Cigarette + other i 42 140 0.58 ( 0.39• 0.87) 0.64 ( 0.43- 0.97)1 0.57 ( 0.35- 0.92) 0.58 ( 0.39- 0.88)~ 0.55 ( 0.35- 0.87) Excludad/Trend ' ! 23 124 SQUAMOUS CELL CARCINOMA Non exposed 52 496 1.00 1.00 1.00 1.00 1.00 Only ciqarottm ! 27 5 7 0.39 ( 0.23- 0.67) 0.37 ( 0.21- 0.68) 0.41 ( 0.21- 0.82) 0.39 ( 0.23- 0.67) 0.35 r, 0.18- 0.67) Never ciqaretta 90 205 0.43 ( 0.21- 0.91) 0.45 ( 0.21- 0.95) 0.48 ( 0.21• 1.08) 0.44 { 0.21- 0.91) 0.45 ( 0.21- 0.96) ~ 11 cigarette + other 140 0.79 ( 0.38- 1.63) 0.83 ( 0.40- 1.74)1 0.87 ( 0.38- 1.97) 0.74 ( 0.35- 1.57) 0.57 ( 0.24- 1.37) fxcludad/Trand 9 11{{ 124 i SMALL CELL CARCINOMA Non exposed 28 496 1.00 1.00 1.00 1.00 1.00 Only cigarette 19 577 0.83 ( 0.42- 1,61) 0.77 ( 0.38- 1.55) 0.57 ( 0.26- 1.23) 0.91 ( 0.46- 1.79) 0,58 ( 0.28- 1.20 ) Nevm r cigarette 17 205 0,84 ( 0.43- 1.67) 0.93 ( 0.46- 1.67) 0.83 ( 0.41- 1.71) 0.92 ( 0.46- 1,85) 0,79 ( 0,39- 1.56) Cigarette + otha r • 140 0.14 ( 0.02- .04) 0.14 ( 0.02. 1.10) 0.12 { 0.02- 0.97)~ 0.15 ( 0.02• 1.1a) 0.14 ( 0•02• 1•07) Excludad/Trend s 124, ( ADENOCARCINOMA _ Non exposeo Only cigarette ~ Never ciqarette € Cigarette + other ExcludId/Tivnd OTHER 124 129 48 n E2 10 496 1.00 677 0.85 ( 0.62• 1.15) 205 0.83 ( 0.55- 1.25) 140 0.57 ( 0.34- 0.96) 124 Non exposed 381 496 1.00 Only cigarotte 48 577 1.06 ( 0.66- Never cigarette 17 205 1.00 ( 0.53- Cigarette + other 8! 140 0.69 ( 0.31- Excluded/Trand 4f 124 >75% OF LIFESPAN IN RURAL AREA OR INTERMEDIATE CITIES Non exposeo Only cigarette Never cigarette 13 61 45 Cigarette + other 16 Exc2uded/Trendl 21 >76% OF LIFESPAN IN URBAN AREA 189 161 93 44 88 Non exposetl 70 215 Only cigarette 105 310 Never cigarette 40 85 Cigarette + other 22 75 Excluded/Trend 7 26 1,00 0•60 0.67 0.47 ( 0.40- ( 0.42- ( 0.24- 1,00 1.00 0•95 ( 0.68- 1•32) 0.98 ( 0.66• 1.46) 0.92 ( 0.60• 1.41) 0.85 ( 0.52- 1.39) 0.64 ( 0.38- 1.09) 0.57 ( 0.29- 1.09) 1.00 71.72) 1.19 1.88) 1.17 1.56)f 0.79 0.70- 2.03) 0.61- 2.26) 0.34- 1.81) 1.00 1.30 ( 0.72- 0.81 ( 0.36- 0.62 ( 0.22- 1.00 1.00 0.91) 0.60 ( 0-40- 0.91) 0.58 ( 0.35- 1.08) 0.67 ( 0.42- 1.08) 0.58 ( 0.34• 0.92) 0.47 (, 0.24- 0.92)1 0.45 ( 0.21- F 1,00 1,00 1.14 ( 0.76- 1.70)i 1.14 ( 0.76• 1.70) 1.29 ( 0,77• 2.18)i 1.29 ( 0.77- 2.18) 0.90 ( 0.49- 1.63)1 0.90 ( 0.49- 1.63) I 1.00 1•16 ( 0.73• 1.23 ( 0.67- 0.80 ( 0.39- 1.00 2.37) 1 1.07 ( 0.66- 1.75) 1.83) f 1.02 ( 0.54- 1.92)) 1.74) 0.69 ( 0.30- 1.56)~ F 1.00 0.98) 0.60 ( 0.40- 0.92) 0.98) 0.71 ( 0.44- 1.15) 0.94) 0•46 ( 0.23• 0.90) 1.00 1.84) 1.15 ( 0.77- 1.73) 2.27) 1.27 ( 0.75- 2.16) 1.66) 0.86 ( 0.46- 1.59) (1) Modol W.hido sex, conter, sex'certter and a,e (2) Modol fndude sax, center. sex'cenfer, aae and propoRion of residential type in the last 35 yrs (REUP) (3) Model Indudo sox, contor, sex'conter, age, proportion of residential type in the last 35 yrs (REUP) and educational level (EDUC) (4) Model inctudo sex, contor, sex'center, age and tluration of exposure to list A agents (OCLAY) (SJ M11ode( inctucfe sex, centor, sex-cenlor, age and frequency consumpt on of vegetables (VEGE) 01 _ 1.00 0,84 ( 0.59- 1.19] 0.82 ( 0.53- 1.27) 0.51 ( 0.28- 0,92) 1.00 1.25 ( 0,70- 2.23) 1.20 ( 0.59- 2.41) 1.12 ( 0.48- 2.65) 1.00 0•56 ( 0.35- 0.88) 0.71 ( 0,44• 1.16) 0•46 ( 0.24- 0.91) 1.00 1.08 ( 0.67- 1.73) 1.28 ( 0.72- 2.29) 0.85 ( 0.41- 1.76) -- - `'06359i3 14---. Risk estimates - Childhood 0-18 years

C C1UN Childhood 0-18 yrs, Number of smokers MEN ONLY t" oc ca casn: i con>sots O 4) 95X CI OR12 95% C1 OR(3) 95% CI ( OR(4 95% CI OR 5 95% Cf No smoker 65 201 1.00 1.00 1.00 1.00 1.00 ( 1 sroker 62 222 0.91 ( 0.58- 1.42) 1.05 ( 0.64• 1.70)1 0.81 ( 0.45- 1.45)1 0.93 ( 0.59- 1.46) 0.87 ( 0.52• 1.46) 2 smokers 9 74 0.41 ( 0.18• 0.93) 0.52 ( 0.22- 1.19) 0.41 ( 0.14- 1.18)1 0.42 ( 0.19- 0.96) ` 0.29 ( 0.11- 0.77) >3 sasokors 4 25 0.75 ( 0.22• 2.57) 1.07 ( 0.31- 3.74) 0.90 ( 0.21- 3.92) 0.99 1 0.29- 3.38) ~ 2.86 ( 0.59•13.96) Excluded/Trend 1 9 0.14 0.14 ) 0.13 0.15 0.14 'WOMEN ONLY Yo smokar 1 snoker 2 smokers 187 295 1.D0 1.00 1.00 1.00 1.00 243 528 0.76 ( 0.59- 0.98) 0.80 ( 0•61- 1•04) 0.84 ( 0.62- 1.14) 0.76 ( 0.59- 0.98) 0.74 ( 0.56- 0.99) 43 117 0.69 ( 0.46- 1.04) 0.67 ( 0.43- 1.03) 0.61 ( 0.37- 1.01) 0.70 ( 0.46- 1.06) 0.79 ( 0.49- 1.27) >3 a.okars 28 55 1.13 ( 0.67- 1.91) 1.17 ( 0.68- 2.01) 1.10 ( 0.61- 2.01) 1.12 ( 0.66- 1.91) 1.09 ( 0.56- 2.12) Excludad/Trend 8~ 16 0.54 0.55 0.44 0.54 0.59 POPULATION BASED STUDIES No ssrokar 152 326 1.00 1.00 1.00 1.00 1.00 tstokar 1 167 426 0.79 ( 0.60- 1.06) 0.84 ( 0.62- 1.12) 0.76 ( 0.64• 1.06) 0.83 ( 0.62- 1.11) 0.75 ( 0.55- 1.03) 2 sswkars 30 126 0.61 ( 0.38- 0.99) 0.67 ( 0.41- 1.09) 0.56 ( 0.31- 1.00) 0.63 ( 0.39• 1.01) 0.68 ( 0.39- 1.17) ?3 saokors 23 54 1.28 ( 0.71- 2.32) 1.45 ( 0.79- 2.64) 1.24 ( 0.63- 2.43) 1.29 ( 0.71- 2.37) 1.95 ( 0.79- 4.81) ~xcludod/Trend 6 18 0.72 0.71 0.60 ~ 0.74 0.71 Ht9SPtTAL BASED STUDIES ?lo sta0ker I smoker 2 smokers a3 s/aokers Excluded/Tr+ndl 3 INlTHOUT OCCASIONAL SMOKERS 129 1.00 1.00 255 0.70 ( 0.49• 1.01) 0.73 ( 0.48- 1.13) 43 0.72 ( 0.40• 1.32) 0.67 ( 0.34- 1.32) 18 0.57 ( 0.22- 1.47) 0.61 ( 0.22- 1.71) 7 0.16 0.15 No snaker 181 364 1.00 1.00 t 1.00 1.00 1.00 1 smoker 235 834 0.90 ( 0.69• 1.16) 0.94 ( 0.71- 1.24) 0.92 ( 0.68• 1.25) 0.92 ( 0.71- 1.19) 0.84 ( 0.62- 1.12)1 2 smokers 37iE 135 0.70 ( 0.45- 1.08) 0.71 ( 0.45- 1.12) 0.65 ( 0.39- 1.09) 0.72 ( 0.47- 1.13) 0.66 ( 0.40- 1.11) >3 smokars l 27/ 54 1.48 ( 0.85• 2.59) 1.59 ( 0.90• 2.81) 1.35 ( 0.73• 2.49) 1.51 ( 0.85- 2.67) 2.01 ( 0.96- 4.22)l Ercludad/Trend 6f 17~ 0.85 0.86 0.74 0.89 0.92 ) AGE <55 YEARS No smoker I smoker 2 smokers >3 smokara €xcluded/Trend AGE SS-C4 YEARS No smoker 1 smoker 2 smokers >3 smokers e'xc1 uded/Trend AGE e5+ YEARS 76 105 16 9 4 No smoker 10® I smoker 127 2 smokers 21 >3 Smokers 14 Excluded/Trend 4 HISTOLOGICALLY CONFIRMED DIAGNOSIS No smokar t 242 1 smoker 2 smokers >3 smokers €xcluded/Trend SQUAMOUS CELL CARCINOMA 294 52 30 9 178 265 73 25 13 1.00 0.88 ( 0.60• 1.30) 0.53 ( 0.28. 1.01) 0.83 ( 0.34- 2.02) 0.21 1.00 1.00 ) 1.00 0.88 ( 0.54- 1.46) 1.08 ( 0.58• 2.01) 0.67 ( 0.43- 1.06) 0.74 ( 0.34- 1.60) 0.79 ( 0.31- 2.01) 0.61 ( 0.30- 1.27) 1.57 ( 0.59- 4.23) 1.95 ( 0.63- 6.02) 0.87 ( 0.33- 2.28) 0.17 1 0.1 6 0.14 1.00 0.86 ( 0.57- 1.30) 0.49 ( 0.25- 0.96) 0.74 ( 0.30- 1.86) 0.21 1.00 t 1.00 0.83 ( 0.52- 1.34) 0.84 ( 0.57- 1.25) 0.45 ( 0.21- 0.99)1 0.52 ( 0.27- 0.99) 0.75 ( 0.29- 1.96)1 0.81 ( 0.33- 1.99) 0.16 E 0.22 206 1.00 1.00 ! 1.00 1.00 0.66 ( 0.46• 0.96) 0.72 ( 0.39- 1.32) 0.63 ('0.24- 1.63) 0.14 € 00 1. 1.00 0.75 ( 0.48- 1.18) 0.44 ( 0.20- 0.97) 0.75 ( 0.25- 2.24) 0.22 1 .00 316 0,78 ( 0.55. 1.09) 0.79 ( 0.55- 1.13) 0.72 ( 0.47• 1.09) 0.81 ( 0.58- 1.14)1 0.80 ( 0.55• 1.16) 70 0.71 ( 0.40- 1.27) 0.69 ( 0.37- 1.27) 0.61 (, 0.29- 1.26) 0.74 ( 0.41- 1.32) 0.80 ( 0.41- 1.55) 29 1.44 ( 0.68- 3.05)i 1.51 ( 0.70- 3.25) 1.19 ( 0.49- 2.89) 1.52 ( 0.71- 3.28) 1.84 ( 0.71- 4.79) 5 0.50 E 9.51 0.47 1 0.50 ~ 0.47 4B6 1.00 7501 0.79 ( 0.63• 0.98) 191 0.64 ( 0.44- 0.92) 80 0.98 ( 0.60- 1.60) 25 0.21 1.00 0.82 ( 0.62- 1.08) 0.59 ( 0.37- 0.92) 1.00 ( 0.57- 1.75) 0.17 1.00 ( 1•00 0.79 ( 0.63• 0.99) 0.76 ( 0.65 ( 0.45- 0.94) 0.63 { 1.02 ( 0.62- 1.68) 1.10 ( 0.22 0.23 0.59- 0.42- 0.59- 0.97) 0.97) 2.04) No smoker III 52 496 1.00 1.00 1.00 1.00 1.00 1 smOker ~ 41 750 0. 49 ( 0.31• 0.77)1 0.51 ( 0.31- 0.82) 0.56 ( 0.32• 0.97) 0.a8 ( 0.30• 0.76) 0.49 ( 0.29- 0.81; 2 smokers 7 191 0 . 43 ( 0.18- 0.99) 0.36 ( 0.14- 0.94) 0.35 ( 0.12- 1.06) 0.43 ( 0.18- 1.00) 0.36 ( 0.12- 1.051 >3 amokers 8 80 1.17 ( 0.50- 2.73) 1.27 ( 0.51- 3.12) 1.48 ( 0.56- 3.89) 1.13 ( 0.46- 2.76) 1.02 ( 0.33• 3.19) €xcluded/Tr®ndl f 25 0.09 ~ 0.09 0.07 ; 0.09 0.10 SMALL CELL CARCINOMA NO slAOker 26 496 1.00 III 1.00 t.oo t.oo 1.00 I smoker ~ 37 7501 0.80 ( 0.47- 5.37)1 0.81 ( 0.46- 1.41) 0.69 ( 0.39- 1.22)1 0.85 ( 0.49• t.d8) 0.69 ( 0.39• 1.19j 2 smokers { 3 191 0.38 ( 0.11- 1.34)I 0.41 ( 0.12- 1.47) o.2s ( 0.06- 1.1a) o.at ( 0.12- 1.as) 0.25 ( O.as- 1.1a~ >r3 smokers ~ 1 80 0.57 ( 0.07- 4.49) 0.58 ( 0.07- 4.51) 0.53 ( ~ 0.07- 4.32) 0.65 ( 0.08• 5.17) 0.65 ( 0.08- 5.24) €xcluded/Trend 1 15 0.38 ~ 0.35 0 . 31 0. 44 t 0.38 ADENOCARCINOMA No smoker 1 smoker 124 496, 1.00 1.00 1.00 1.00 1.00 i 158 750 o.so ( o.so• 1,06) 0.87 ( 0.64- 1.18) 0.89 ( 0.62- 1.27) 0.80 ( 0.60- 1.07)i 0.77 { 0.ss• 1.05) 2 amokera 29 191 0.70 ( 0.44- 1.12) 0.77 ( 0.47• 1.26) 0.71 ( 0.40- 1.27) 0.72 ( 0.45• t.15) 0.73 ( 0.43- 1.24) >3 smokars 17 80 1.10 ( 0.60- 2.03) 1.34 ( 0.72- 2.50)~ 1.07 ( 0.51- 2.22) 1.18 j 0.63- 2.19) 1.17 ( 0.54- 2.52) EXC1udOd/Trond 5 25 0.59 1 0.60 0.55 0.55 0.63 OTHER No smoker 1 smoker 2 smokers >3 smokers Excluded/Trend 496 1.00 750/ 0.99 1911 1 0.91 80 0.70 1.00 0.84 ( 0.66- 1.07) 0.66 ( 0.45- 0.97) 1.12 ( 0.67- 1.84) 0.21 1.00 { 0.64• 1.55)1 1.11 ( 0.46- 1.79)I 0.96 ( 0.23- 2.10) 0.87 25 0.84 >75',C OF UFESPAN IN RURAL AREA OR INTERMEDIATE CITIES 0.83 1 0.68- 1.80)I 0.47- 1.97) 0.29- 2.67))I I 1.00 100 1.00 ( 0.58- 1.73) 1..00 ( 0.64- 1.56) 0.92 ( 0.40- 2.11) 0.89 ( 0.45- 1.76) 0.98 ( 0.31- 3.11) 0.76 ( 0.25- 2.29) 0.82 1 0.85 1.00 1.13 ( 0.67- 1.89) 1.11 ( 0.50- 2.44)~ 1.73 ( 0.54- 5.51) 0.85 NO smoker 113 189 1.00 € 1.00 - 1.00 1.00 ' 1.00 I smokor 1 118 297 0.68 ( 0.48• 0.95) 0.68 ( 0.48• 0.95) 0.64 ( 0.43- 0.95) 0.68 ( 0.48- 0.96) 0.68 ( 0.47- 0.97) 2 smokers 14 63 0.45 (, 0.23- 0.87) 0.45 ( 0.23- 0.87) 0.43 ( 0.20- 0.92) 0.46 ( 0.23- 0.89) 0.43 ( 0.21- 0.88) >•3 smokers 7 21 0.61 ( 0.23• 1.59) 0.61 ( 0.23- 1.59) 0.51 ( 0.17- 1.58) 0.62 ( 0.24- 1.63) 0.66 ( 0.24- 1.76) zxcludrd/Trrnd1 41 5 0.15 0.15 0.15 0.14 i 0.15 >75% OF LIFESPAN IN URBAN AREA NO smoker 70 215 1.00 € 1•00 1.00 1.00 1.00 1 SmOker 129 331 1.22 ( 0.84• 1.78)1 1.22 ( 0.84- 1.78) 1.20 ( 0.78- 1.87)1 1.22 ( 0.83• 1.79) 1.15 ( 0.75- 5. 77) 2 smokers 25 102 0.86 ( 0.49• 1.50}I 0.86 ( 0.49- 1.50) 0.84 ( 0.43- 1.65) 0.85 ( 0.48- 1.50) 0 .93 ( 0.48- t.79) >3 smokara 16 48 1.63 ( Ei 1.63 ( 0.80- 3.31) 0.80- 3.31) 1.54 ( ~ 0.71- 3.35) 1.54 i 0.74- 3.21) 1.94 ( 0.69- 5.45) rxcluded/Trand1 41 15 0.47 II 0.47 0.47 ) 0.50 0.43 (1) Modai Inckude sex, center, sox'centcr and age (2) Model tncfude s.x, oan(ar, sax'cantar, age and proportion of reskentiat type in the last 35 yrs (REUP) (3) Modat ktokxfe sex, Contor, sex•oanter, age, proportan of residential type in the last 35 yrs (REUP) and educational level (EDUC) (4) MOdat inCAtde sax, Canter, sex•oenter, age and duration ot exnosure to list A agents (OCLAY) (5) Modal )~ sex, arntar, sex'centor,.aga and frequency consumption of vegetables (VEGE) ®~ 38 58 13 41 21 Risk estimates - Childhood 0-18 years

C1 UD Childhood 0-18 yrs, Duration (years) (non overiapping) ITALY 2 Total Fcpascd Unexoosed Exduded Min P10 i 11 " Median 03 P90 Max Mean E Std ~ Men Cases 3 2! 0 0.50 0.50 0.50 0.50 0.50 0.50 0.50 0.50 Contr011 97 55 41I 1 0.50 5.00 12.00 ?8.50 18.50 18.50 18.50 14.87 5.81 A1) 100 56 49f 0.50 3.50 11.50 18.50 18.50 18.50 18.50 14.62 6.07 Wom0n Casts 16 12 4 0 11.50 14.50 18.25 18.50 18.50 18.50 18.50 17.54 2.22 Contr0la 76 39 36 1 0.50~ 5.00~ 14.00 18.50 18.50 18.50 18.50 15.55 5.22 AN 92 , 51 40 1 0.50i 10.00 95.00 18.50I 18.50 18.501 18.50 16.02~ 4.74 AH CisC3 19 13 6 0 0.50 11.50 18.00 18.50 18.50 18.50 18.50 16.23 5.18 ~d$ 94 77 2 0.50 5.00 ~ 0 i Al~ 192 10 7 83 2 0.50 5.00 94.001 ~8.50i 18.50 18.50 18.50 15.28 5.50 1TALY 3 Mon Cis®s 1 0 ; 0 ' Controls 12 5 7 0 5.00 5.00 13.00 18.50 18.50 18.50 18.50 14.70 5.92 A11 13 5 8 0 5.00 5.00 13.00 18.50 18.50 18.50 18.50 14.70 5.92 WOrnCn Casts 15 9 5 0 8.00 8.00 18.50 18.50 1:8.50 18.50 18.50 16.17 4.63 Controls 38 26 12 0 5.00 8.00 1 18.50 ~ 18.50 18.50 18.50 18.50 16.81 4.08 A11 531 35~ 18 0 5.00 8.00 18.50 18.50~ 18.50 18.50 18.50 16.64 4.17 All CiSCS 1B 9 7 0 8.00 8.00 18.50 18.50 18.50 18.50 18.50 16.17 4.63 COnVdf 50 31 19 0 ~ 5.00 8.00 18.00 18.50 1$.50 18.50 18.50 16.47 4.38 AII 66 40 26 0 5.00 8.00 18.25 18.50 18.50 18.50 18.50 16.40 4.38 MOn CAS@4 16 6 10 0 10.00 10.00 14.00 17.75 18.50 18.50 18.50 16.08 3.46 ConIr01S 8 4 4 0 12.00 12.00 15.25 18.50 18.50 18.50 18.50 16.87~ 3.25 AII 24 10 14 0 10.00 11.00 14.00 18.50 18.50 18.50~ 18.50 16.40I 3.21 Women Cases 33 19 14 0 3.00 5.00 12.00 18.50 18.50 18.50 18.50 15.001 5.23~ Controls 31 17 11 3 0.50 5.00 10.50 18.50 18.50 18.50 18.50 14.471 5.85 AH 64 36 25j* 31 0.50 5.00 12.00 18.50 18.50 18.50 18.50 14.751 5.46~ A}! C35L7 49 25 24 0 3.00 6.00 12.50 18.50 18.501 18.50 18.50 4.82 15.26 Controls 39 21 16 3 0.50 7.00 12.00 18.50 18.50! 18.50I 18.50 ~ 14.93 5.47 AJI 88 46 39 3 0.50 6.00 12.00 18.50 18.50f 18.50 18.50 15.111, 5.07 PORTUGAl2 Men Casts 10 4 6 0 7.00 7.00 11.50 16.00 17.25 18.50 18.50 14.37 5.06 Contr0ls 17 7 10 0 5.00 5.00 I 7.00 18.50i 18.50 18.50j 18.50 14.57 5.95 AII 27 11 /6 0 5.00 7.00 7.00 16.00 18.50 18.50~ 18.50 14.50 5.38 WomCn Ci5'"f 23 "2 11 0 11.00 11.00 13.50 18.00 18.50 18.50 18.50 16.25 3.14 COrUrOls 36 20 16 0 0.50 3.75 6.50 17.75~ 18.50 18.50 18.50 13.50 6.53 AII 591 32~ 27 0 0.50 5.00 11.50 17.75~ 18.50 18.50 18.50 14.53 5.61 All Ci68s 33 16 17 0 7.00 11.00 13.50 17.50~ 18.50 18.50 18.50 15.78 3.61 Controls 53 27 26 0 0.50 4.50 7.00 18.00 18.50 18.50 18.50 13.78~ 6.29 All 861 43 43 0 0.50 5.00 i1.00 17.50 18.50 18.50 18.50 14.52 5.49 SPAIN Men Cases 6 4 1 2 0 16.00 16.00 17.25 18.50 18.50 18.50 18.50 17.87 1.25 Controls 13 12 ' 0 12.00 17.00 17.75 18.50 18.50 18.50~ 18.501 17.71 1.86 All 19 16 3 0 12.00 16.00 ':7.75 18.50 18.50 18.50 18.501 17.75 9.69 Women Casts 65 52 11 2 0.501 5.50 13.00 18.50 18.50 18.50 18.50 14.89 5.531 Controls 146 111 31 4 2.00 11.00 16.00 18.50 18.50 18.50% 18.50 16.50 3.851 AH 211 163 42 6 0.50 9.50 15.00 18.50 18.50 18.50 18.50 15.99 4.501 AII t;9S9s '1 66 13 0.50 5.50 13.50 18.50 18.50 18.50 18.50 15.11 5.391 Controls 169 123 32 4 2.00 12.00 17.00 18.50 18.50 18.5018.50 16.62 3.721 All 230 179 45 6 0.50 10.00 15.00 18.50 18.50 18.50 98.50 96.15 4.35~ SWEDEN Mcn Cases 23 16 0 3.50 6.00 9.75 14.00 17.75 18.50 18.50 13.34 4.69 Controls 36 20 16i 0( 1.00 5.501 14.00 17.50~ 18.50, 18.50 18.50 15.05 5.26 Ap 59 36 23~ 0 1.00 6.00 12.50 15.50 18.50 18.50 18.50 14.29 5.02 WOtflCn aSOS 47 25 23 0 2.50 6.00 16.00 18.50 18.50 18.50 18.50 15.46 5.22 Controls 76 47 29 0 1.00 5.00 11.00 18.00' 18.50 ~ 18.50 18.50 14.77 5.15 AU 123 ?2 51 0 1.00 6.00 11.00~ 18.50 18.50 18.50 18.50 15.01 5.15 All CisCS 70 41 29 0 2.50 6.00 11.00 18.00 18.50 18.50 . 18.50 14'.63 5.07 Controls ~ 112 67 45 0 1.00 5.00 12.00 18.00 18.50 18.50 18.50 14.85 5.14 All I 182 108 74 0 1.00 6.00 ~ 11.50 18.00118.50 18.50 18.50 . 14.77 5.09 UNlTED KINGDOM MGn CaSCS 3 2 1 0 18.00 18.00 18.00 18.00 78.00 18.00 18.00 18.00 0.00 Controls 14 10 4 0 2.50 2.75 17.00 17.501 18.00 18.25 18.50 14.70 6.32 ~ All 17 12 5 0 2.50 3.00 17.00 18.00 18.00 18.00 18.50 95.25 5.86 Women Cases 23 17 6 0 4.00 8.00 17.00 17.00 18.00 18.50 18.50 16.12 3.93 Controls 126! 89i 37 0 1.00 10.001 17.00 17.00 18.00 18.00 18.50 15.80 4.24 All 149 906~ 43 0 1.00 10.001 17.00 17.00 18.00 18.00 18.50 ~ 15.85 4.17 AI/ CiSCf 26 19 0 4.00 8.00 17.00 17.00 18.00 18.50 18.50 16,32 3.75 COnlr019 140 99 41 0' 1,00 9.001 17.00 17.00 18.00 18.00 18.50 15.69~ 4.46 All 166 118 48 01 1,00 9.00 i7.00 17.00 18.00 18.00 18.50 15.79/ 4.35 "0p,.,75wJ5V

dIWN Childhood 0-18 yrs, Weighted number of smokers I7ALY 2 ?ota( Exooscd Unexposed ~ Exduded Min I P10 Q1 Median I Q3 ~ P90 Max Mean Std ~ Men CaSAa 3 1 2 0 0.25 0.25 0.25 0.25 0.25 0.25 0.25 0.25 CCnt7DlE 97 55 41 1 0.25 0.50 0.75 0.75 .1.00 1.50 E ~ 2.00 0.86 0.35 1 Afl 100 56 43 0.25 0.25 0.75 0.75 1.00 1.50 I 2.00 0.85 0.36 WOrt1Cn CiSM 16 12 4 0 0.75 0.75 0.751 0.88 1.25 1.50 1.75 1.04 0.35 ControlS 76 39'E 36 0.25 0.75 0.751 0.75 1.00 1.50 2.25 0.90 0.35 AII 92 511 40 0.25 0.75 0.75 0.75 1.00 1,50 2.25 0.93 0.35 AIl C33La ~ 19 13 b' 0 0.25 0.75 0.75 0.75 1.25 1.50 1.75 0.98 0.40 COnltol3 173 94 77 2 0.25 0.50 0.75 0.75 1.00 1.50 2.25 0.88 0.35 AH 192 107 83 2 0.25 0.50 0.75 0.75 1.00 1.50 2.25 0.89 0.36 ITALY 3 Men Cases 1 0 1 0 e { Controls 12 5 7 0 0.25 0.25~ 0.75 0.75 0.75 1.25 1.25~ 0.75~ 0.35' A11 13 a 8 0 0.25 0.25 0.75 0.75 0.75 1.25 1.25f 0.75 0.35 WOri1Cn Ca&o8 15 9 ~6 0 0.75 0.75 0.75 0.75 0.75 1.00 1,00 0.78 0.08 Controls All 38 53 26 35 12. 18 0 0 0.75 0.75 0.75 0.75 0,75 0.75 0.75 0.75 0.75 1.00 0.75 1.00 2.00 2.00 0.86~ 0.31 0.841 0.27 AlI ;Ca Ci ConttOla AH 16 50 66 9 31 40 19 28 0! 0 0 0.75 0.25 0.25 0.75 0.75 0.75 0.751 0.75 0.75/ 0,75 0.75t 0.75 0.75 1.00 0.75 1.00 0.75 1.00 1.00 2.00 2.00 0.781 0.06 0.84 0.31 0.83 0.28 PORTUGALI Men Cases Controls AH 16 8 241 6 4 /0 10 4 14 0 0 0 0.75 0.75 0.75 0.75 0.75 0.75 0.75 0.75 0.75 1.00 0.88 1.00 1.00 1.25 l 1.00 1.00 1.50 1.25 1.00 1.50 1.50 0.92 1.00 0.95 0.13 0.35 0.23 WOrtfCn GSCI 33 19 14 0 0,25 0.25 0.75 0.75 1.00 1.25 1.25 0.83 0.28 COntf0ls 31 17 1! 3 0.25 0.25 0.75 0.75 ~ 0.75 1.00 1.25 0.72 0.23 ` Afl 64 36 251 3 0.25 0.25 0.75 0.75 1.00 1.00 1.25 0,78 0.26 Atl Cases 49 25 24 0 0.25 0.50 0.75 1:.00 1.00 1.00 1.25 0.85 0.25 Controls 39 21 SS 3 0.25 0.50 0,75 0.75 I 0.75 1.00 1.50 0.77 0.27 All 88 46 39 3 0.25 0.50. 0.75 0.75 1.00 1.00 1.50 0.82 0.26 POR7UGAL2 Msn Cases Cantrots All Warcn CasEs Controls All Atl Cisaa Controls Atl 10 4 s 0 0.75 0.75 0.75 0.75 0.75 0.75 0.75 0.75 0.00 ~ 17 ' 10J 0 0.25 0,25 0.25 0.75 0.75 2.00 2.00 0.79 0.59 27 11 16~ 01 0.25 ~ 0.25 0.75 0.751 0.75 0.75 2.00 0.77 0.45 23 12 11 0 0.50 0.75 0.75 0.75 0.75 0.75 1.00 0.75 0.11 36! 20' 16 0 0.25% 0.25 0.50 0.75 0.75I 1.00 1:00 0.66 0.26 591 E 321 27 0 0.25~ 0.25 0.75 0.75 0.75~ 1.00 1.00 0.70i 0.22 33 16 17 0 0.50 0.75 0.75 0.75 0.75 0.75 i.00 0.75! 0.09 53 27 26 0 0.25 0.25 0.25 0.75 0.75 1.00 2.00 0.69' 0.36 66 43 43 0 0.25 0,25 0.75 0.75 0.75 1.00 2.00 0.721 0,29 SPA1N MCn Cases 6 41 2 0 0.75 0.75 0.75 0.75 1.13 1.50 1.50 0.94 0.38 Controls f 13 121 1 0 0.75f 0.75 0.75 0.75 0.75 1.00 1.00 0.79 0.10 E All € 19 161 3 0 4 0.751 0.751 0.75 0.75 0.75 1.00 1.50~ 0.83 0.20 Wonton Cases 65 Controls 1461 52 11 111l 31 2 4~ 0.25 0.25 0.50 0.751 0.75 0.75 0.75 0.75 0.75 0.75 1.00 1.00I ?.25 1.s0 0.76 0.82 0.23 0.21 A11 All ~ 2111 asls 71 163 42 56 13 6 2 0.25 0.25 0.75 0.50 0.75 0.75 0.75 0.75 0.75 0.75 1.00 1.00 1.50 1.50 0.80 0.78 0.22 0.24 ~ Controls 159 32 123 4 0.25 0,75 0.75 0.75I 0.75 1.00i 1.50 0.82 0.20 All 230 . 1791 45 6 0.25 0.75 0.75 0.75 0.75 1.00i 1.50 0.80 0.22 SWEDEN MCn Cases 23 16 7 ~~~o.z s 0.251 0.501 o.7s 0.881 1.7s 1.7s 0.80 0.47 C~1tro{a 36 20 161 0 0.25 0.75~ 0.75 0.75 1.25 1.75 1.75 0.99 0.44 All 59 36 23 OI 0.25 0.255 0.75 0.75 1.13I 1.?5 5.75 0.90 0.46 WOrt1Cn WCS 47 25 22 1 01 0.25 0.501 0.75 0.75 1.00II 1.25 1.75 0.83 0.30 Controls 76 47 29 0 0.25 0.75 0.75 0.75 1.00~ 1.75 2.00 0.88 0.40 All 123 72 1 51 1 0 0.25 0.75 0.75 0.75 1.00 1.25 2.00 0.86 0.37 Ail Ci15Cf 70 41 29 0 0.25 0.25 0.75 0.75~ 1.00 1.25 1.75 0.82 0.37 Controls 112 67 45 0 0.25 0.75 0.75 0.75I ?.00 1.75. 2.00 0.91 0.41 AU 182 108 1 T4 0 0.25 0.25 0.75 0.75,1 1.00 1.751 2.00! 0.88 0.40 MCn CisCs 3 2 1 0 0.75 0.75 0.75 0.75 0.75 0.75 0.75 0.75 0.00 Controls 14 10 4 0 0,50 0.63 0.75 1.00 1.75 1.75 1.751.18 0.51 All 17 12 5 0 0.50 0.75 0.75 0.88 1.75 1.75 1.75 1.10 0.49 Women Cases I 23 i7 6 0 0.75 0.75 0.75 0.75 1.001 1.50 2.50 0.941 0.45 i Controls ~ 126 89 37 01 0.25i 0.75 0.75 0.75 1.00( 1.75 2.25 0.951 1 0.41 All 149 106 43 0 0.25i 0.75 0.751 0.751 1.00 1.75 1 2.50 0.95 0.42 A}1 Cases 26 19 ' 0 0.75 0.75 0,75 0.75 1.00 1.50 2.50 0.92 0.43 ~Contfol3 140 991 41 0 0.25 0.75'p 0.75~ 0.75 1.00~ 1.75 2.25 0.97 0.43 Au 166 118 [ 4e 0 0.25 0.751 0.7s 0.75 1.00 ':.75 2.50 0.97 0.42 206-359?338

OSUD Occasional smoking, Duration (years) (non overlapping) MEN ONLY I Tolal Exposed Unexposed Excluded Min ~ Plo 01 1 Median Q3 P90 Max I Mean Std Mart Casaf 154 43 110 1 0.50 0.50 1.00 2.00 10.001 20.00 44.00 6.81 10.99 Controls 566 156 397 13 0.50 0.50 1.00 2.00 4.50! 12.00 46.00 4.88 8.50 All 737 199 507 31 0.50 0.50 1.00 2.00_ 5.001 12.00 46.00 5.29 9.10 Wornon Casos o 0 0 0 Controls o 0 0 ~ 0 ~ Atf 0 01 0 0 Pdl Ca3es 157 43 110 4 0.50 0.50 1.00 2.00 10.00 20.00 44.00 6.81 10.99 ConV01s 660 156 397 27~ 0.50 0.50 1.00 2.00 4.50 12.00 46.00 4.88 8.50 All 737 199 507 31 0.50 0.50 1.00 2.00 5.00 12.00 46.00 5.29 9.10 iNOMEN ONLY Man Casas 0 0 0 0 I Controlz 0 0 0 0 ~ € ~ P ~ All 0 0 0 0 P r 'r6nten Cases 527 97 419 11 0.50 0.50 1.00 2.00 5.00 20.00 44.00 6.23 9.68 Controls 950 186 747 ?7 0.50 0.50 ~ 1.00 2.00 1 5.00 20.00 50.00 6.18~ 9.83 All 1625 283 1166 177 0.50 0.50 1.00 2.00 5.00 20.001 50.00 6.20j 9.76 Atl Cfis©s 550 97 419 34 0.50 0.501 1.00 2.00 5.00 20.00 44.00. 6.23 9.68 Controls 1078 1 1 1 747 143 0.50 0.50 1.00 2.00 5.00 20.00 50.00 6.18 9.83 All 1626 8 3 , 2 1166 177 0.50 0.50 1.00 2.00 5.00 20.00 50.00 6.20 9.76 POPULATION BASED STUDIES MM Cases 9 1 23 681 0 1.00 1.00 1.00 3.00 10.00 20.00 44.00 7.76 10.93 Controls 444 125 3141 5 0.50 0.50 ':.00 'E 2.00 4.00 10.00 46.00 4.74 8.53 All 535 148 382 5 0.50 0.50 1.00 ' 2.00 5.00 11.00 46.00 5.211 8.97 Won18n Cases 287 60 226 1 0.60 0.50 1.00 1.00 5.00 16.50 44.00 4.88 8.29 Controls 506 ?01 404 0.50 0.50 1.00 1.00 5.00 23.00 50.00 6.27 10.31 AN ?93 161 630 2 0.50 0.50 1.00 1.00 5.00 1 20.00 50.00 5.75 9.60 Atl Cases 171 83 294 1 0.50 0.50 1.00 2.00 5.00 18.00I 44.00 5.68 9.12 Controls 950 226 718 6 0.50 0.50~ 1.00 2.00 5.00 15.00! 50.00 5.42 9.38 All 1328 309 1012 7 O.SO 0.50 1.00 2.00 5.00 7.00( 50.00 5.49 9.30 HOSPITAL BAS€D STUDIES nan Casas 47 Corltrols 73 All 120 `.~om an Cases 199 Controls 379 At1 $78 8 Coses 246 ConUols 452 All 698 19 27 1 0.50 0.50 0.50 1.00! 4.00 34.001 41.00 5.97 11.48 29 36 8 0.50 0.50 1.00 1.00' 4.00 14.00 39.00 4.95 8.52 48 63 9 0.50 0.50 1.00 1.00 i 4.00 14.00 41.00 5.35 9.70 371 152 10 0.50 1.00 1.00 3.00 10.00 31.00 40.00 8 42 11.37 asi 278 16 0.50 1.00 s.00 2.00 5.00 20.00 45.00 122 430 26 0.50 1.00 1.00 2.00 7.00 20.00 45.00 5.78 9.97 179 it 0.50 0.50 1.00 2.00 10.00 31.00 41.00 7.59 ':1.36 :14 314 24 0.50 1.00 1.00 2.00 5.00 18.00 45.00 170 493 35 0.50 1.00 1.00 2.00 5.001 20.00 45.00 YUITHOUT OCCASIONAL SMOKERS Men Ca scs~ 112 0 110 2 ----- - Controls 406 0 397 9 I ~ ! 2f~' 635c~'~~~~ . AG $18 0 507 11 1 ' WomCn Casa 430 0 a1s r ' --- Controlf 310 0 747 63 I Alf 1240 0 1166 74 AlI Cases 642 0 G29 13 E Controls 1216 0 1144 72 All 1758 0 1673 85 AGE <55 Y€ARS Man Casaa ae ~ Controls 170 17 39 0 0.50 0.50 i.00 2.00 4.00 12.00 31.00 4.76 7.5~ 52 116 2` 0.50 0.50 1.00 2.00 6.00 22.00 40.00 6.08 9.74 AH 229 69 155 51 0.50 0.50 1.00 2 00 5.00 22.00 40.00 5.75 9.21 Nrornan Casas 1a8 29 106 3 0.50 i.00 1.00 1.00 3.00 18.00 31.00 5.09 7.52 Controls 254 73 174 0.50 0.50 1.00 2.00 6.00 24.00 50.00 6.96 10.24 All 392 102 280 10 0.50 1.00 1.00 2.00 6.00 21.00 50.00 6.43 9.55 :rVl Cases 195 45 145 4 0.50 1.001 1.00 ':.50 4.00 15.00 31.00 4.97 7.44 E Controls 42s 125 290 11 0.50 0.50 1.00 2.00 6.00 24.00 50.00 6.59 10.01 All 1 62 171 435 15 0.50 0.50 1.00 2.00 5.00~ 21.00 50.00 6.75 9.35 ~84YEARS Man Cases 62 14 38 0 0.50 0.50 1.00 2.00 3.00 41.00 44.00 7.57 14.85 ContrOls 216 51 163 2 0.50 0.50 1.00 1.00 4.00 6.00 42,00 ) 3.39 6.1E All 269 65 201 2 0.50 0.50 1.00 2.00 4.00 10.00 44.00 4.29 8.81 Woman 60 3 0f 166 35 127 4 0.50 0.50 1.00 2.00 5.00 20.001 44.00 6.40 10.1C ls Controls 304 61 243 0 0.500.50 1.00+ 1.00 4.00 10.00! 35.00 4.11 7.4C All 535 9s 370 69 0.50 0.50 1.00 l 1.001 4.501 15.00 i 44.00 4.951 a.s Al1 Casaf 228 ® d 165 i4 0.50 0.501 1.00 2.00 5.00 27.00~ 44.00 5.73 11.SC Controls 675 12 406 57~ 0.50+ 0.50 1.00 1.00 4.00 10.00 42.00 3.79 6.8E AI1 803 161 571 71f O.SOI 0.50 1.00 1.00 4.00 10.00 4a,00 4.6 8 8.6' AGE 65+YEARS Man Casas Controls All Worns n Ca 'sas ~ CCntr810 Al AN Casef Controls All 46 12 33 1.001 1.00 1.00 5.50 13.00 20.00 34.00 8.83 10.35 180 53 178+ 9 0.501 0.50 1.00 2.00 5.00 12.00 46.00 5.12 9.Oc 240 65 151 24 0.50 0.50 1.00 2.00 7.00 15.00 46.00 5.81 9.3£ 223 33 186 4 0.50 0.$0 1.00 2.00 7.00 25.00 40.00 i.06 11.OC 392 52 330 10 0.50 0.50 1.00 2.00 8.50 30.00 45.00 7.51~ 11.4C 699 85 516 98 0.50 0.50 1.00 2.00 7.00 30.00 45.00 7.34 11.1F 284 45 21s 20! 0.50 1.00 1.00 2.00 10.00 25.00 40.00 7.s3 10.7: 655 105 448 102' 0.501 0.50 1.00 2.00 6.00 17.00 46.00 6.301 90.3C 939 150 667 122 0.50 0.50 1.00 2.00 7.00 20.00 46.001 6.67 10.4~ Descriptive statistics - Occasional smoking

~ E i6 E E9 Spous Descriptive statistics of quantitative variables

NE,, O1WS<14 53 91 1.00 1.00 1.00 1.00 1.00 € 14<C1WS<.18 17 51 0.57 ( 0.30- 1.09) 0.61 ( 0.30- 1.26) 0.80 ( 0.32- 2.03) 0.58 ( 0.29• 1.13) € 0.57 ( 0.29- 1.09), 18<C1WS 6 9 1.01 ( 0.33- 0.95 ( 0.27- 3.33) 1.71 ( 0.39- 7.46) 0.99 ( 0.32- 3.08) f) 1.00 ( 0.32- 3.09) Excluded/Trend 1 0 0.21 ~ 0.14 E 0.17 0.25 0.20 ~ NE., C1WS<14 28 120 1.00 1.00 i 1.00 1.00 14<Ctw3<18 7 61 6• 1.04) 0.41 { 0.1 0.49 ( 0.19- 1.24)iI 0.54 ( 0.21- 1.41) 0.48 ( 0.19- 1•22) ~ 18<C1WS 3 30 08• 0.31 ( 0. f.14) 0.39 { 0.10- 1.47 )I 0.40 ( 0.10• 1.57 ) t 0.21 ( 0.04- 1.00) Exeluded/Trendl 2 ~ 101 0.02 0.04 I i 0.04 ) 0.02 ~ NE., C1'!4S<14 37 73 1.00 1.00 1.00 1,00 1.00 14<C1WS<•18 301 76 0.73 ( 0.40• 1.321 0.69 ( 0.37- 1,30} 0.76 ( 0.40- 1.45) 0.78 ( 0.43- 5•41)f 0.69 ( 0.38• 1.27) 1<C1WS 21 6 0.59 ( 0.11• 3.15) 0.49 ( 0.09- 2,70) 0.51 ( 0.09- 2.82) 0.56 ( 0-10• 3.11)ffff 0.76 ( 0.13- 4.30) 6xc2uded/rrend 21 4 0.25 E 0.31 ~ 0.42 ~ 0.25 ~ 0.25 ~ ALL CEtiT€RS Layel of exp,osuro NE., C?WS<.14 14<C1Ws<.18 1e<c1Ws Exc2udid/Trendl 741 1991 0.10 ALL CENTERS WITH DIETARY DATA NE., CiW5<.14 394 14<C1WS<.18 78 18<C1WS 23 Cases I Controls I OR 1 95% Cl OR(2) 95% CI 500 1078 1.00 1.00 104 332 0.75 ( 0.57- 0.99) 0.78 ( 0.58- 1.05) 37 107 0.88 ( 0.57- 1.34) 0.82 ( 0.52- 1.32) Ekcluded/rrendl 9! 25! 0.08 ALL CENTERS WITH EDUCATIONAL LEVEL AND TYPE OF RESIDENCE NE., C1WS<14 335 818 14<C1W8<.18 68 240 21 81 0.92 0.84 ( 0.59- 1. 18<C1WS Exc1 uded/Trond FRANCE 3.13) 1t GERMANYI NE., C)WS<r14 14<C1WS<18 18<CtVYS 63 9 2 5xc2uded/Trend GERMANY2 NE „ C1WS<14 1 136 1591 1.00 18<C1WS ~ 5 21 3.45 ( 0.62•19.10) 2 ITALY 1 l Exc.t udid/Trend ITALY 3 NE., CiWS<.14 14<C1WS<18 18<C1w3 Exc2 uded/Trend PORTUGALI _ NE., C1W5<14 14<C1WS<18 18<C1WS Excluded/Trend PCRTUGAL2 ~`xcluded/Trendj SPAIN SWEDEN NE., C1WS<14 14<C1WS<18 1e<c1Ws 6xcluded/Trend ~ ! ITALY 2 NE., C1W5<14 14<C1WS<.18 18<C1WS 9 9 1 0) 0i 4 0 0 51 14 5 ~ ~xcluded/Trendj UNITED KINGDOM NE., C1WS<r14 € 22 14<C1W5<18 18<C1WS 768 1,00 1.00 200 0,76 ( 0.55- 1.06) 0.78 ( 0.55- 1.09) 581 0.97 ( 0.57- 1.64)~ 0.99 ( 0.58• 1.70) 30 0.17 !!0.18 190 1.00 25 1.11 ( 0.47. 2.65) 11 0.62 ( 0.12- 3.10) 2 113 46 12 31 0.83 2 27 20 61 24 1.00 0.98 ( 0.28- 3,47) 31 0.00 ( 0.00-99,99) 1 0 0•56 8 4 3 0 29 ® ~1WS Childhood 0-18 yrs, Weighted smoking parent years 0.16 1.00 2.51 ( 1.27 ( 0.16 1.00 0.38 ( 0.10• 1.49) 1.39 ( 0.38- 5.19) 0.84 0.80 751 1.00 0.64 ( 0.30- 1.37) 8( 1.00 ( 0.30- 3.36) 0! 0,42 0.08 1.00 ( 1.00 19)~ 0.85 ( 0.60- 1.21) 0.54- 1. ( 57) 0.91 ( 0.53- 1.55) 0.09 1.00 1.37 ( 0.56- 3.39) 0.86 ( 0.16- 4.57) 0.82 0.10 t 1.00 0.87• 7.25) 3.59 ( 1.05-12.23) 0.13-12.20) 2.56 ( 0.23-28.02) 0.05 1.00 ~ 1.00 ~ 1.00 1.00 0.88 ( 0.22- 3.45)I 0.64 ( 0.15- 2.83)I 0.75 ( 0.20- 2.87) 1.05 (, 0.26- 4.30) 0.00 ( 0.00-99.99)! 0.39 ( 0.00•99•99), 0.00 ( 0.00•99.99) 0.00 ( 0.00-99.99) E ~ 0.74 ~ 0.36 1 0.56 0.50 1.00 ( 1.00 ! 0.87 ( 0.28• 2.76)I 0.45 ( 0.13- 1.63)I 0.86 ( 0.07•11,17)'i 1.08 ( 0.08-14.53 !!!{) ! F 0.85 1,00 0.61 ( 0.28- 1.31) 0.88 ( 0.25- 3.02) j 0.31 OR(3) 95% Cl 1.00 0.86 ( 0.60- 1.22) 0.90 ( 0.52- 1.54) E ; 0•08 1.00 0.86 ( 0.60- 1.22) 0.90 ( 0.52- 1.54) 0.10 1.00 0.88 ( 0.59- 1.33) 1.10 ( 0.59- 2.07) 0.23 0.14 1.00 2.85 ( 0.64•12.80) 3.74 l, 0.23-61.39) ~ 0.10 115 1.00 1 1.00 1.00 5~ 1.16 ( 0.13-10.63)I 0.89 ( 0.09- 9,11)E 0.97 ( 0.10- 9.77) 20 0.65 ( 0.16- 2.60) 0.57 ( 0.14- 2.37) 0.54 ( 0.13- 2.27) ~ 0.48 ~ 0.44 (1) Modo) ildude sox, center, sax'center and age (2) Modol inch)de sox, conter, sex'center, age and proportion of residential type in the last 35 yrs (REUP) (3) Mode) ine/cde ser, center, sax•cant®r, ag®• proportion of residential type in the last 35 yrs (REUP) and educational level (EDUC) (4) Modol InUude sox, center, sex'o®nter, age and duration of exposure to list A agents (OCLAY) (B) Model InGude sax, canter, sex•canter, age and frequency consumption of vegetables (VEGE) OR 4) 95% CI OR(5) 95% Cl 1 00 1 0 . 0 0.77 ( 0.58- 1.02) 0.75 ( 0.54- 1.05)1 0.85 ( 0.55- 1.31) 0.99 ( 0.59- 1.69) 1.00 1,00 0.87 { 0.61- 1.24}~ 0.84 ( 0.56- 1.26) 0.84 ( 0.48- 1.47) 1.12 ( 0.60- 2.09) 0.09 1.00 1.00 0.77 ( 0.55- 1.07) 0.75 ( 0.54- 1.05) 0.95 ( 0.55- 1.62) 0.99 ( 0.59- 1.69) 0.16 ~ 0.18 ~ 0.15 1.00 2.58 ( 0.88- 7.51) 1.31 ( 0.14-12.76) 0.15 1.00 0.38 ( 0.10- 1.51)' ~ 1.76 (, 0.41- 7.46) 0.81 F 0.85 ~ 1.00 0.63 ( 0.29- 1.37) ~ 1.05 ( 0.31- 3.53) i ~ 0.44 0.57 1 E € 0.10 1•00 1.00 0.60 ( 0.28- 1.29) 1.06 ( 0.31- 3.62) 0.38 .,.,.< n_<n ....•,..- 1,00 1.00 1.00 1.54 1 0.61- 3.89) 1.16 ( 0.48- 2.78)~ 1.21 ( 0.50• 2.92) 1.09 ( 0.20- 6.05) 0.65 ( 0.13- 3.32) 0.74 ( 0.14- 3.82) ~ 0.93 ) 0.88 0.96

55 NE., 99 1.00 ; 1.00 1.00 1.00 1.00 19<C1WD<  26 19 1 43 0.77 ( 0.40- 1.46) 0.90 ( 0.44- 1.85) 1.33 ( 0.54- 3.30) 0.76 f, 0.39- 1.48) 0.77 ( 0.40- 1.46) ) 2 9 0,35 ( 0•07- i,74) 0.23 ( 0.03- 5.96) 0.71 ( 0.07- 7.25) 0.34 ( 0.07- 1.69) ( 0.35 ( 0.07- 1-70) Erc1 uded/Trend 1 0 0,16 0.12 0.14 ~ 0.19 0.16 NE., 66 189 1,00 1.00 1.00 1.00 ~ 1.00 32 0,73 ( 0.30- 1•82) 0.89 ( 0.35- 2.27) 1.01 ( 0.39- 2.65) 0.75 ( 0.30- 1.87)1 0.79 ( 0.31- 1.97) a6<ctwD 1 5 0.53 ( 0.05- 5,21) 0.79 ( 0.07- 8.3$) 0.89 ( 0.08• 9.71) 0.57 ( 0.06- 5.75)1 0.62 ( 0.06- 6.21) 2 3 0.40 0.39 0.53 0.43 ~ 0.44 NE., C11'(D<19 130 156 1.00 1.00 1.00 € 1.00 1•00 7 4 1.87 ( 0.52- 6,8T) 2.35 ( 0.61- 9.08) 2.55 ( 0.64-10.15) 1.86 ( 0.51- 6.76) 1.91 ( O.S2- 6.94) $ 1 6.72 ( 0.70•64,60) 5.98 ( 0.61-58.35) 5.35 ( 0.53•54.48) 6.99 ( 0.71-69.02) 6.73 ( 0.70-64.75) Excluded/Trend + 1 2j 0.06 E 0.05 ~ 0.05 0.05 0.05 N€., CiMO<s19 114 1.00 I 1.00 1.00 1.00 1.00 19<C11W <.26 7 0.72 ( 0.08- 6.61)~ 0.74 t 0.08- 6.84) 0.78 ( 0.08- 7.27) 0.76 ( 0.08- 7.15)~ 0.78 ( 0.08- 7.13) 26<C1WD ` 19 0.16 ( 0.02- 1.68) I 0.12 ( 0.01- 1.49 ) 0.11 ( 0.01- 1.37) 0.18 ( 0.02- 1.90) 0.15 ( 0.01- 1.57) € Excluded/Trsnd1 01 0! 0.12 ~ 0.09 ; 0.08 ~ 0.11 ~ 0.10 €.rcluded/Trsndl 9 ALL CENTERS VYiTH EDUCATIONAL LEVEL NE., 01Yf0<18 350 19<C1WD<•26 26<C1hD NE., C1H'0<19 19<C1PFD<26 2e<C1WD ~YCluded/Trend FRANCE C71S9<19 26<c1wD GERMANY 1 C11'~<.19 19<C1WDu26 Excludsd/Trend GERMANY2 19<C1YtDt26 28<C1Yf0 G RMANY3 NE., C1W0<19 19<C1H'0<.28 Excluded/Trend ITALY I NE, , 1Yf0<19 19<C14fD<26 26<C1W0 Excludid/Trend ITALY 2 NE., C1140<.19 19<C1W0<28 26<01WD Excluded/Trend ITALY 3 NE., C1Pf0<19 19<C114D<28 28<C1iYD E'xcluded/Trend! PORTUGAL1 NE., C14<.19 ~ 39 19<C11Y0<.28 , 28<C1S'(D 3 cxcluded/Trend PORTUGAL2 NE., C1W0<.19 19<CiP10<26 26<C1PfD Exc1 udedlrrend SPAIN NE., C1YrD<19 19<C1WV<28 26<C1W0 5'xc1 uded/Trend SWEDEN NE,, C1WD<19 19<C1PfD<26 26<C1W0 5`xc1 uded/Trend I UNITED KINGDOM 01 0 0 29 3 50 14 5 2 56 10 4 199 251 0.03 AND TYPE OF RESIDENCE 854 1.00 205 0.90 ( 0.64- 1.28) 80 0.65 ( 0.36- 1.17) 114 1,00 153 0•86 ( 0.61- 1.20) 59 0.66 ( 0.37- 1.18) 301 0.09 10 107 34 14 21 0.08 29 17 4 0 < 31 0.66 43 8 2 0 4 83 21 8 0 0.05 1.00 1.00 1.00 0.32 ( 0.13- 0.80) 0.37 (, 0.15- 0.95) 0.41 ( 0.16- 1.06) 0.26 ( 0.06- 1.21)~ 0.31 ( 0.07- 1.47) 0.34 ( 0.07- 1.62) 0.01 0.26 1.00 0.62 ( 0.19- 2.09) 1.00 ( 0.15- 6.73) 1.00 0.59 0.82 0.56 D_C1 WD Childhood 0-18 yrs, Weighted duration (years) ( 0.14• 2.52)1 ( 0.06•10.77)1 0.03 E 0.02 ~ 0.02 1.00 1.00 1.00 3.76 ( 1.22•11•57) 6.54 ( 1.71-25.10) 3.38 ( 0.69-16.70) 2.10 ( 0.37•12•07) 2,45 ( 0.27-22.58) 1.23 ( 0.10-15.85) 1.00 1-00 ( 1.00 0.88 ( 0.23• 3.41)i 0,84 ( 0.19- 3.80)1 0.60 ( 0.12- 3.05) 0.00 { 0.00-99.99)~ 0.00 ( 0.00•99•99)~ 0.14 ( 0.00-99.99) 0.26 0.54 1.00 0.26 1.05 ( 0.08-14.17) 0.56 ( 0.05- 1.43) 1.00 ~ 1.00 0.90 ( 0,43• 1.89) 0.82 (, 0.37- 1-78) 0.67 ( 0.22- 2.03) 0.67 { 0.22- 2.04) 0.49 1.00 0.70 ( 0.30- 1.64) 0.85 ( 0.24- 3.01) 0.51 0.51 1.00 0.67 ( 0.28- 1.57) 0.89 ( 0.25- 3.18) 0.51 OR(3 95% Cf OR(4) 95% Cl ~ OR(5 95% CI 1.00 1.00 1.00 0.90 { 0.64- 1.29)~ 0.81 ( 0.61- 1.08) 0.8s ( 0•61- 1.20)~ 0.62 ( 0.34- 1.13) 0.66 ( 0.41- 1.08) 0.68 ( 0.38- 1•21 () 0.04 ~ 1.00 1.00 0.85 ( 0.60- 1.19) 0.85 ( 0.61- 1.20) 0.67 ( 0.38- 1.20) 0.68 ( 0.38- 1.21) 0.09 1•00 0.83 0.68 0.51 0! 2$ ;1) Model includo sex, center, sox'eantor and age (2) Mod®1 fnckudo sex, eentor, sex`center, age and proportion of residential type €n the last 35 yrs (REUP) (3) Model inGuda sox, canter, sex'cenler, ag®, proportion of residential type in the last 35 yrs (REUP) and educational level (EDUC) (4) Model )na}tlde sex, eenter, sex'center, a9e and duration of exposure to list A agents (OCLAI) (5) Modal /nGudo sex, center, sex'center, age and frequency consumption of vegetables (VEGE) { ( 0.03 1.00 1.00 0.94-( 0.66- 1.34)/ 0.97 ( 0.65- 1.45) 0.62 ( 0.34- 1.15)i 0.72 ( 0.36- 1.44) 0.05 0.99 1.00 0.35 ( 0.14- 0.89) 0.14 ( 0.02- 1.12) 0.01 0.14 1.00 ; 1•00 0.59 ( 0.13- 2.64) 0.82 ( 0-19- 3.61) 0.00 ( 0.00-99.99)! 0.00 ( 0.00-99.99) 1 0.26 E 1.00 ; 0.55 ( 0.16• 1.89)1 2.35 f, 0.22-25.52)1 ~ 0.63 € 1.00 0.61 ( 0.14- 2.59) 0.95 ( 0.07-12.45) 0.61 1.00 0.37- 1-85) 0.94 ( 0,45- 1.99) 0.22- 2.08) 0.65 ( 0•21- 1-98) 0.48 i 0.48 0.06 0.10 0.99 f 0.57 1.00 ( 1.00 ( 0 65 ( 0 27- 1 56) 0 63 ( 0 26- 1 50) ~ 0.87 ( 0.25- 3.08)~ 1.05 ( 0.29- 3.81) 1€ ~ 1.00 0.90 ( 0.42- 1.90)1 0.78 ( 0.25- 2.40)I 0.63 stimates - Childhood 0-18 vears 0.06 0.05 1.00 1.00 0.89 ( 0.63- ~ 1.26) 1.00 ( 0.66- 1.50) 0.66 ( 0.37- 1.20) 0.69 ( 0.35- 1.37) - ~ 0.10

E_Q1EV Spouse, ever exposed MA-e€ctmRs Lavml of @xnosuro Cas@s Cont rols OR(1) 95%Ct OR(2 95% CI ~ OR(3) 95% CI E OR(4 95% CI OR(5 95% Ci Non exposed ExpoSCd 305 344 838 700 1.00 1.16 ( 0.93• 1.44) 1 i 1.00 1.16 (0.92-1.46) 1.00 ~ 1.11 ( 0.85• 1.46) 1.00 1.18 ( 0.94-1.46) 1.00 1.14 ( 0.89-1.45) Exdud"l'rond i 1 1 4 1 ~ IIE I ALL CENTERS WITH EDUCAT IONAL LEVEL AN D TYPE OF RESIDENCE EJon exposetl 187 620 1.00 °ratposed 244( 53711 ,15 ( 0.88-1.50) EcdudodlTrond~ 671 151!i ALL CENTERS WITH DIETARY DATA Non expos@d E%posed 231 534 1.00 1.00 1.00 1.00 1.00 271 499 1.14 ( 0.89- 1.45) 1.16 ( 0.90- 1.49)~ 1.15 ( 0.86- 1.54) 1.15 ( 0.89- 1.47) 1.14 ( 0.89• 1.45)~ cluded/Trend €x clu d e d/Trend 7 <3 99~ E ~ ~ FRANCE Non @xposea 39 65 1•00 1.00 1.00 7.00 7-00 Exposed 38 86 0•78 ( 0.43- 1.44)~ 0.62 ( 0-31- 1-24) 0.63 ( 0.26- 1.53) 0.77 ( 0.41- 1.42) 0.77 ( 0.42- 1.41) Exclurfed/Trend 0I o ! Non exposed 34 153 1.00 1.00 1.00 1.00 1•00 E%poLed 41 76 1.43 ( 0.77- 2.65) 1 1•56 ( 0.79- 3.08) 1.51 ( 0.76- 3.00) 1.45 ( 0.77- 2.73) 1•56 ( 0.83- 2.94) fxcluded/Trend~ 0~ ~ GERMANY2 Non exposea 66 96 1,00 ~ 1.00 1.00 1•00 1.00 Exposed 1 76 65 1.17 ( 0.68- 1.99) 1.10 ( 0.64- 1.89) 1.03 ( 0.60- 1.78) 1.16 ( 0.68- 1.98)~ 1.14 ( 0.67- 1.95) Excluded/Trendi 01 o GERMANY3 Non mxposmo 22 35 E%posmd 9 i7 s'xcludid/Trendi 0 0 ITALY 1 1.00 1.00 1.0o j 1.00 1.00 0.88 ( 0.30- 2.61) 0.84 ( 0.27- 2-64)i 0-55 ( 0.16- 1•88)~ 0.97 ( 0.31- 3.02) 0.78 ( 0.25- 2•39) € Non @xpoa@tl 16 123 00 1 . 00 1 . 1.00 1.00 E%pos@d 241 97 ( 0.45- 2.25) . 00 1 ( 0.55- 3.02) 1 . 29 1.13 ( 0.48- 2.66) 1.30 ( 0.55- 3.04) EXcluded/Trend i 01 € ITALY 2 @xposod Non 0 1 106 .00 1.00 1 € 1.00 1.00 ExpO aetl 9 67 0.51 ( 0.17- 1.56) 0.46 ( 0.13- 1.57) { E 0.55 ( 0.12- 2.58) 0.50 ( 0.16- 1.49) I Excl udid/Trend 0 0 ~ ITALY 3 Non exposmd Exposed 4 23 1.00 1.00 1.00 1.00 1.00 12 I 26 1.94 ( 0.47- 8,07) 1.76 ( 0.39. 7.93) 0.84 ( 0.16- 4.48) 1.75 ( 0.40- 7.58) 2.93 ( E 8 + 1 0 Exc1uded/Trend~ 511 ~ ~ ~ PORTUGAL 1 Non @xposea 29 25 1.00 1-00 Exposed 20 14 1.63 ( 0.63- 4,21) ~ 1.58 ( 0.61- 4.09) <zcludod/Trend 01 0 PORTUGAL 2 Non exposed Exposed 16 38 1.00 1.00 1.00 17 15 6.16 ( 1.71•22•22)~ 3.85 ( 0.94-15.86) E 5.79 ( 1.60-20.97) Ezcluded/Trend 0 OI € SPAIN Non exposed Exposed 23 50 1.00 1.00 1.00 1 1.00 1.00 48 107 0.95 ( 0.49- 1.85) 1.00 ( 0.49- 2.02) 0.97 ( 0.47- 2.00)~ 0.99 ( 0.50- 1.96) 0.98 ( 0.50- 1.92)1 € Excl uded/Trendi 0 ~ 2 ~ €€€ I 1 l SWEDEN Non exposed Exposed 38 62 1.00 € 1.00 1.00 1.00 321 50 1.16 ( 0.61- 2,20)1 1.15 ( 0.60- 2.19) ~ 1.19 ( 0.63- 2.25) 1.19 ( 0.62- 2.26) Exeluded/Trend 01 0 ~ ~ € S UNITED KINGDOM Non exposed Exposed 8 60 1.00 1.00 1.00 1.00 1.00 E € 18 80l 1.80 (, 0.71- 4.59) 1.79 ( 0.69- 4.66) 1.67 ( 0.63- 4.44) E 1.78 ( 0.68- 4.66)i 1.89 ( 0.73• 4.89)I Excluded/Trend 01 01 _ 0.58-14.77) (1) Model usUudA se c, an(er, sex'canter and age (2) Modcl include sex, center, sex'center, age and proponion of residential type in the tast 35 yrs (REUP) j3)1~IodN indude sax etnler, sr~r•renter, age• proporlion of residential type in the tast 35 yrs (REUP) and educational level (EDUC) (4) Modml include sex, center, sex'center, age and duration of exposure to list A agents (OCLAY) (5) Model Indude sex, center, aex'center, age and frequency consumption of vegetables (VEGE)

C1UN Childhood 0-1 H yrs, Number of smokers HiSTC/LOGICALLY CONFIRMED DIAGNOSIS Tot91 Exoosed Unexposed ~ Exduded Min P10 Q1 Median ~ 03 P90 Max Mean Std I Men 3e3 152 ' 4 77 1 1.00 1.00 `:.00 1 1.00 1.00 2.00 4.00! 1.26 0.64 Controls 560 335 236 9 1.00 1.00 1.00 1.00 ~ 2.00 2.00 5.00 1.42 ~ 1 0.74 AI 732 409 313~ 10~ 1.00 1.00 1.00 1.00~ 2.00 2.00 5.00 1.39 0.73 Wortien Se9 531 333 190 8 1.00 1.00 1.00 1.00 2.00 2.00 4.00 1.36 0.68 Controls 1076 716 344 16 1.00 1.00 1.00 1.00 2.00 2.00 4.00 1.36 0.71 All 1607 1049 534 24~ 1.00 1.00 1.00 1.00 2.00 2.00 4.00 1.36 0.70 AN CSLCS 683 407 267 9 °s.00 1.00 1.00 1.00 1.001 2.00 4.00 1.34 0.67 Controis 1656 1051 580 25 1.00 1.00j 1.00 1.00 2.00 2.00 5.00 1.38 ~ 0.72 A4f 2339 1458 847 34 1.00 1.00~ 1.00 1.00 2.00' 2.00 5.00 1.37 0.75 =UAMOUS CELL CARCINOMA Men ~ ~ ~ c on tras 500 335 236 9 1.00 '.00 1.00 1.00 2.00 2.00 5.00 1.42 0.74 All 608 339 260 9 1.00 1.00 1.00~ 1.00 2.00 2.00 5.00 1.42 0.74 WOn1M1 C33C3 97 59 37 1 1.00 1.00 1.00` 1.00 2.00 3.00 4.00 1.58 0.93 Controls 1078 716 344 16 1.00 1.00 1.00 1.00 2.00 2.00 4.00 1.36 0.71 All 1173 '.`75 381 17 1.00 1.00 1,00 1.00 2.00~ 2.00 4.00 1.38 0.731 IJI C850s 125 63 61 1 1.00 1.00 1.00 1.00 2.00 3.00 4.00 1 54 0.91 Controls 1656 1051 680 25 1.00 1.00 1.00_ 1.00 2.00 2.00 5.00 : ~ 1 38 0.72 AJI 1781 t114 641 26 1.00 1.00 1.00 1.00 2.00 2.00 5.00 1.39 0.73 SMALL CELL CARCINOMA Mcn Cases a t 7 7 0 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 0.00 Controls 500 335 236 9 1.00 1.00 1.00 1.00 2.00 2.00 5.00~ 1.42 0.74 All 594 342 243 9 1.00 1.00 ?.001 1.00 2.00 2.00 5.00 1.42 0.74 WOrt1Cf1 CafC3 67 42 24 1.00 1.00 1.00 1.00 1.00 2.00 3.00 1.19 0.45 Controls 1076 716 344 16 1.00 1.00 1.00 1.00 2.00 2.00 4.00 1.36 0.71 All 1143 758 368 17 1.00 1.00 1.00 1.00 1.00 2.00 4.00 L 35 0.70 AIl CSSes Controls All 81 1856 1737 49 1051 1100 31 580 611 1 25 26 ?.00 1.00 1.00 1.00 1.00 1.00 1.001 1.00 1.00 1.00 1.00 1.00 1.00 2.00 2.00 2.00 2.00 2.00 3.00 5.00 5.00 1.16 !.38~ 1.37 0.43 0.72 0.71 ADENOCARCINOMA Men Cases 80 44 35 1 DO ?.00 1.00 ?.00 i.00 2.00 4.00 1.23 0.60 Controls ~ 580~ 335 236 9 1.00 1.001 1.00~ ?.00 2.00 2.00 5.00 1.42 0.74 All 660 379 271 10 1.00 ':.001 1.00 ;.00 2.00 2.00 5.00 1.40 0.73 WORHIR Cases 281 176 101 4 1.00 1.00 1.00 1 1.00 2.00 2.00 4.00 1.37 0.65 Controls 1076 716 344 16 1.00 1 1.00 1.00 1.00 2.00 2.00 4.00 1.36 0.71 1 All 1357 892 445 20 1.00 1.001 1.00 1.00 2.00 2.00 4.00 ?.36 0.70 AII CaSe1 361 220 136 5 1.00 1.00 1.00 i.00 2.00 2.00 4.00 1,34 0.65 Controls 1656 1051 580 25 1.00 1.00 1.00 1.00 2.00 2.00 5.00 1.38 0.72~ AII 1 2017 1271 716 30 1.00 1.00 1.00 1.001 2.00 2.00 5.00 1.37~ 0.711 OTHER MOn Cise~ 30 19 11 0 1.00 1.00 1.00 1.00 2.00 3.00I 4.00 1.47I 0.841 Controls ~ 580 335 238f 9 1.00 ?.00 1.00 1.00 2.00 2.00/ 5.00 ?.42I 0.741 All 610 354 247f 9 1.00 1.00 i.00 1.00 2.00 2.00' 5.00 1.43f 0.75 WorrrGn t;ases 86 56 28 2 1.00 1.00 1.00 1.00 1.00 2.00 3.00 1.23 0.50 Controls 1076 716 344 16~ 1.00 1.00 1.00 1.00 2.00 2.00 4.00 1.36 0.711 All ?162 772 372 18?.00 1 1.00 1.00 1.00 1.00 2.00 4.00 1.35 0.70 AH C35c9 116 75 39 1.00 1.00 1.00 `.00 1.00 2.00 4.00 1.29 0.61 Controls 1656 1051 580 25i 1.00 1.001 1.00 1.00 2.00 2.00 5.00 1.38 0.72 Atl 1772 1126 619 271 i.00 1.001 1.00 1.00 2.00 2.00 5.00 1.37 0.71 >78% OF LI ESPAN IN RURAL AREA OR INTERMEDIATE CITIES MCn CiseS I~® 76 30 45 `.00 1.00 1.00 1.00 1.00 1.50 4.00 i.17 0,59 Controls ~ 225 120 103 2 I ',.00 1.00 1.00~ 1.00 2.00 2.00 3.00 1.34 0.54 AIl 301 150 148 3 1.00 1.00 1.001 1.00 2,00 2.00 4.00 1.31 0.55 WCfnen CifOf 237 140 94 3 1.00 1.00 1.00 1.00 2.00 2.00 4.00 1.34 0.65 Controls 462 290 169 3 1.001 1.00 1.00 1.00 1.00 2.00 4.00 1.29~ 0.63 All 699 - 430 263 6 1.00 1.001 1.00i 1.00 1.00 2.001 4.00 1.311 0.64 t Al CSSCS ~~ 313 170 139 4 1.00 1.001 1.00 1.00 1.00 2.00 4.00 1.31 0.64 Controls ~ 687 410~ 272 5 1.00 1.OOf 1.001 1.00 1.00 2.00 4.00 1.31 0.60 All 1000 I 580 411 9 1.00 1.00i 1.00 1.00 1.00 1 2.00 4.00 1.311 0.62 >75'F OF LIFESPAN IN URBAN AREA Men Cases 46 Controls I 257 All 4, 305 33 155 188 15 96 111 0 1.00 6 `:.00 6 1.00 1.00 1.00 1.00 1.00 1.00 1.00~ 1.00 1.00 1.00 2.00 2.00 2,00 2.00~ 3.00 3.00~ 4.00 5.00 5.001 1.39 1.50 1.48 0.75 0.82 0.81 WOn1Ct1 C8s0 ~196 137 55 41 1.00 1.00 1.00 1.00 1.00 2.00 4.00 1.34 0 .69 1 Controls ~ 454 326 119! 9! 1.00 1.00 ?.00 1.00) 2.00 2.00 4.00 1.44, 0.78 All 650 I 463 174 .3f 1.00 1.00 1.00 1.00 00 2.001 2.00 4.00 1.41 0.76 All WSO II~ 244 170 70 4~I- 1.00 1.00 1.00 1.00 1.00 2,00 4.00 1.35 0.70 ~ 711 Controls 481 ~ 215f€ 15 1.00 ~ 1.00 1.00 1.00 2.00 2.00 5.00 1.46 0.80 AI7 955 651 265 i 19 1.00 1.00 1.00 1,00 2.00 2.00 5.00 1.43 0.77 206359333Ei

C1 WS Childhood 0-18 yrs, Weighted smoking parent years HdSTOl.OGICALLY CONFIRMED DIAGNOSIS T ot9! Etposed ~ Unexposed ~ Excluded Min I P10 `, 01 { Median 03 P9o { Max Mean ~ Std ~ MCn GsCS 752 74 77 1 0.13 2.25 8.25 10.31 14.25 18.25 27.13 / 10.45 5.37 Contraf S80 335 236 9 0.25~ 3.00 7.88 12.63 14.25 19.00 40.13 1 11.60 6.64 Afl 732 409 313 10 0.13~ 3.00 7.88 11.25 14.251 18.75 40.13 f 11.39 6.44 WOfTIM 531 333 190 8 0.25 4.13 8.25 13.13 14.25 78.63 40.13 11.69 6.17 ~ Controk 1076 6 71 344 16 0.25 3.50 8.25 13.81 14.25 17.50 35.00 11.94 6.20 All 1607 1049 1 534 24. 0.25 3.75 8.25 13.13 ~ 14.25 18.38 40.13. 11.861 6.19 AH CasCS 663 407 267 9 0.13 3.88 8.25 11.88 14.25 18.63 40.13 11.47 6.05 Contras 1656 1051 580 25 0.25 3.38 8.25 13.13 14.25 18.13 40.13 11.83 6.35 /W 2339 1458 847 34 0.13 3.50 8.25 13.13 14.25 18.50 40.13 11.73 6.26 SQUAMOUS CELL CARCINOMA MCtt WSCS 28 4 24 ~ 0 5.63 5.63 6.94 8.25 13.63 19.00! 19.00 10.28 5.94 COnUOIs 680 335 236 9 0.25 3.00 7.88 12.63 14.25 19.00 40.13 11.60 6.64 All 608 339 260 8 0.25, 3.00 7.88 12.63 14.25 19.00 40.13 11.58 6.63 lhbRlOn OSCS 87 59 37 1 1.25 3.38 8.25 13.13 14.75! 23.63 40.13 13.57 7.57 Controls 1076 716 344 16 0.25 3.50 8.25 13.81 14.25 f 17.50 35.00 11.94 6.20 AIl 1173 775 381 17 0.251 3.50 8.25 13.63 14.25 18.38 40.131 12.07 6.33 AA ClSf2 125 63 61 1 1.25 5.63 8.25 13.13 14.75 19.00 40.13 13.36 7.48 COnttas 1656 1051 580 25 0.25 3.38 8.25 13.13 14.25 18.13 40.13 ~ 11.83 6.35 All 1781 1114 641 26 0.25 3.38 8.25 73.131 14.25 18.50 40.13 11.92 6.42 SMALL CELL CARCINOMA Men C.asca 14 7 0 2.25 2.25 7.88 8.25 8.25 13.86 13.88 $.14 3.36 Controls 580 ' 335 236 9 0.25 3.00 7.88 12.63 14.25 19.00 40.13 11.60 6.64 All 594f 342 243 9 0.25 3.00 7.88 12.00 14.25 18.75 40.13 11.53 6.61 Woman cases 67 42 24 1 0.38 3.50 8.25 12.38 14.25 18.00 19.00 10.82 5.16 Controls 1076 718 344 16 0,25 3.50 8.25 13.81 14.25 17.50 35.00 11.94 6.20 AH 1143 758 368 17 0.25 3.50 8.25 13.50 14.25 17.75 35.00 11.88 6.15 All Fn15CS 81 48 31 7 0.38 3.13 8.25 8.63 14.25 18.00 19.00 10.44 5.00 I Controls 1051 580 25 0.25 3.38 8.25 13.13f 14.251 18.13 40.13 11.831 6.35 i100 611 26 0.25 3.38 8.25 13.13I 14.25 1 18.06. 40.13 11.77 6.30 Men C25CS 80 44 35 0.13 1.88 7.31 10.31 14.25 15.75 20.88 9.83 5.00 Cantrols 580 335 236 9 0.25 3.00 7.88 12.63 14.25 19.00 40.13 11.60! 6.64 All 660 379 ~ 271 10 0.13 3.00 7.88 11.63 14.25~ 18.50 40,13 11.39 6.49 WINnfn G3CS 281 176 101 4 0.25 4.13 7.88 10.94 14.25 18.50 33,25 11.28! 6.23 Controls 1076 716 344 16 0.25 3.50 8.25 13.81 14.25 17.50 35.00 11.94iI 6.20 All 1357 892 945 20 0.25 3.63 8.25 13.13 14.25 17 J5 35.00 11.81 6.21 Atl CSSCS 361 220 136 5 0.13 3.69 7.88 10.88 14.25 14.25 17.88 33.25 10.99 6.02 Controls 1656 1051 580 25 0.25 3.38 8.25 "3.13~ 18.13 40.13 11.83 6.35 AU 2017 1271 716 30 0.13 3.38 8.25 13.13 14.25 18.13 40.13 11.69 6.30 OTHER MCSt C850S ;30 19 ?1 0 1.13 1.88 6.25 13.13 15.75 19.75 27.13 12.77 6.23 1 CCfltf018 580 335 236 9 0.25 3.00 7.88 12.63 14.25 19.00 40.13 11.60 8.64 E AII 610 354 247 9 0.25 3.00 8.13~ 13.13 14.25 19.00 40.13~ 11.66 6.62 WOrtron CmSf3 86 56 28 2 0.25 5.63 8.25 14,25 14.25! 16.50 19.00I 11.69'€ 4.61 Controls 1076I 716 344 16 0.25 3.50 8.25 13.81 14.25I 17.50 35.00 11.94I 6.20 All 1162 f '72 372 18 0.25 3.75 8.25 13.88 14.25~ ~ 17.50) 35.00 11.93' 6.10 AO CtSQS 116 75 39 2 0.25 5.63 8.25 13.88 14.25 18.38 27.13 11.96 5.05 Contlat 1656 1051 580~ 25 0.25 3.38 5{ 13.13( 14.25 8. 18.13 40.13 11.83 5.35 All 1772 1126 619 7 0.25 3.38 ~ 8...5I 13.31I 14.25 18.131 40.13 11.84 6.27 >7554 OF LIFESPAN IN RURAL AREA OR INTERMEDIATE CITIES Men GSC4 76 30 45 0.13 4.19 6.75 8.25 11.25 14.06 15.75 92 8. .79 3 COiltOis ~ 225 '20 103 2 0.25 3.00 '.88' 9.63 14.25 19.00 1 35.00 i . 23 i .64 6 All 301 150 148 3 0.13 3.19 7.88i 9.19 14.25~ 18.00 35.00 10.77 6.23 Women CiSCS 237 140 94 3 1.13 5.25 8.25 12.75 14.25 19.00 40.13 12.01 5,92 Controls 462 290 169 3 0.25 3.06 8.25 13.13 14.25 18.00I 33.25 11.84 6.61 All 60D 430 283 6 0.25 4.13 8.25 13.13 14.25 18.50i 40.13 i 1 .89 6.38 Rll 3 CaSC 313 170 139 4 0.13 4.94 8.25 10.94 14.25 78.50 40.13 Conlraf 687 410 272 5 0.25 3.00 8.25 13.13~ 14.25 18.38 35.00 Alf 1000 680 411 9 0.13 3.75 8.25 12.38 14.25 18.50 40.13 ~755G OF LIPESPAN IN URBAN AREA Men CiSC4 48 33 15 0 1.00 1.88 8.25 11.63 14.25 19.25 27.13 11.48 6.07 COntras ~ 257 155 96 6 0.25 2.63 7.50 13.75 14.25 18.50 40.13 11.77 6.82j A11 i 305 188 111 6 0.25 2.63 7.88 13.13 14.25 19.00 40.13 11.72 6.68 WOfnCn Ca;CB 196 137 55 4 0.25 3.38 7.88 11.50 14.25 ;5.00 39.25 10.87 5.80 Contro's 464 326 119 9 0.75 I 4.25 8.25 14.25 14.25 18.00 35.00 12.61 6.00, AH 650 463 174 13! 0.25 4.13 8.25 13.88 14.25 17.00 39.25 12.07 5.00 All Ca:CS 244 170 70 4 0.25 2.63 7.88 11.56 14.25 16.06 39.25 10.94 5.84 COntrai 711 481 215 15 0.25 4.00 8.25 14.25 14.25! 18.00 40.13 12.34 6.29 AII 955 651 285 19 0.25 3.75 8.25 13.88, i4.251 17.25 40.13 11.97 6.20 ,O~~C 93,~j48 0-18 vears Cescrio6ve statistics - Childhood

CIWD Childhood 0-18 yrs, Weighted duration (years) ITALY 2 Total Exoosed UnexpOsed Excluded Min P10 Q1 ( Median 03 P90 ~ Max Mean ~ Std ( Men C3ses ' 3 1 2 0 0.50 0.50 0.50 0.50 0.50~ 0.50€I 0.50 0.50 COnltO{S ~ 97 55 41 l 1 0.75 1.90 10.13 19.00 19.00 ~ 34.504 65.50 17.98 12.21 AM 100 56 43 0.50 1.55 8.81 19.00 19.00 34.50 ' 65.50 17.67 12.32 WOn1Cn ~d 12 4 0 18.50 19.00 19.00 20.00 23.50 27.50 38.00 22.33 5.67 Controls 76 39 36 1 0.10 3.00 13.50 19.00 23.00 ~ 33.50 45.00 18.48~ 10.341 All 92 51 40 1 0.10 5.50 14.50 19.00 23.00 31.50 45.00~ 19.39 9.54 Ak C85es 19 1 13 6 0 0.50 18.50 19.00 19.00 22.00 27.50 38.00 20.65 8.13 COnttO93 17 1 94 7 7 2 0.10 2.00 13.13 19.00 21.50 33.50 65.50 18.19 11.42 A11 192 107 83 2 0.10 2.00 13.50 19.00 21.50 33.50 0°5.50 18.49 11.07 i7dLY 3 M6n CSSCS 1 0 1 0 COnlrOls 12 5 7 0 2.85 2.85 5.50 19.00~ 19.00 19.00 19.00 13.07 8.17 AH 13 5 8 0 2.85 2.85 5.50 19.00 19.00 19.00 19.00 13.07 8.17 WCroCn F Ca.,es 16 9 6 0 1.90 1.90 8.50 19.00 19.00 23.00 23.00II 13.9211 7.38 Controls 38 26 12 0 1.90 5.50 18.50 19.00 19.00 38.00 42.00~ 18.92~ 9.41 AM 53 35 18 0 1.90 5.50 12.50 19.00 19.00I 26.00 42.00 17.63 9.10~ Rtl CS.3CS 16 9 0 1.90 1.90 8.50 19.00 19.00 23.00 23.00 13.92 7.38 Controls 50 31 19 0 1.90 5.50 14.25 19.00 19.00 26.00 42.00 17.96 9.35 AN 66 40 26~ 1 0 1.90 4.88 11.00 19.00 19.00 24.50 42.00 17.06 9.02 MCn CosCs 16 6 10 0 10.50 10.50 10.88 16.06 19.00 19.00 19.00 15.25 4.20 Controls 8 4 4 0 12.50 12.50 15.75 19.95 32.70 44.50 44.50 24.23 13.99 Af/ 24 10 14 0 10.50 10.69 12.50 19.00 19.00 32.70 44.50 18.84 9,8: WOmen Cases 33 19 14 0 0.55 1.401 2.55 14.25 19.00 34.50 35.15 14.02 11.1: Controls 31 17 11 3 1.00 1.901 8.50 14.25 19.00! 19.00 27.00 13.17 7.00 All 64 36 25 3 0.55 `:.901 6.00 14.25 19.00 27.00 35.15 13.62 9 28 All CaSef 49 25 24 0 0.55 1.90 6.50 14.25 19.00 28.50 35.15 14.31 5.b: COnlr0ls 39 21 15 3 1.00 5.50 9.50 14.25 ~ 11.1 0 20.90 44.50 15.28 9.4G1 AM 88 46 39 3 0.55 1.90 8.50 14.25 0 , 19.0 27.00 44.50 14.75 9 5. PORTUGAL2 MOn cases 10 4 6 0 7.50 7.50 6.50 13.00 16.50 16.50 16.50 12.50 4 69 COntr0ls 17 7 10 0 1.65 1.65 2.75! 14.25 19.00 36.75 36.75 14.41 12.tE~ All 27 11 16 0 1.65 2.75 7.501 14.25 19.00 19.00 36.75 13.72 9 P• WOrt1Cf1 Cases 23 12 11 0 5.75 9.50 12.00 15.38 19,00 I 19.00 27.00 .15.52 6 5C Controls 36 20 16 0 0.50 1.15 4.25 11.00 19.00 f 21.50 32.38 11.98 E 94 All 59 32 27 0 0.50 1.90 6.25 14.25 I 19.00 20.00 32.38 13.31 ' 9: Atl Cis@s 33 16 17 0 5.75 7.50 10.50 15.38 18.50 19.00 27.00 14.77 ; ~_ COnIr01s 53 27 26 0 0.50 1.65 3.50 12.50 19.00 23.00 36.75 12.61 9 68 A11 86 43 43 0 0.50 1.90 6.75 14.25 19.00 20.00 36.751 13.41 E 3: SPA1N MCn Cases 6 4 2 0 19.00 19.00 19.00 19.00 '27.88 36.75 36.75 23.44 'e Br l COnUOiS 13 12 I 0 9.38 13.88 16.13 19.00 19.00 20.25 30.00I 18.31 : oc ~UI 19 16 ! 31 0 9.38 13.88 18.50 19.00 19.00 30.00 € 36.751 19.59 ` E•O Wofian C85l9 ~ 65 52 11 21 0.25 1.90 9.81 14.25 19.00 20.25 57.00 13.92 5 2t Controls 146 '<11 31 4 1.55 2.95 10.13 14.25 ~ 19.00 25.63 38.25( 15.21 b'd All 211 163 42 6 0.25 2.00 10.13 14.25 19.00 25.63 57.00 14.80 8 sc A1~ ClSGS °1 55 13 2 0.25 1.90 10.31 14.25 19.00 21.00 57.00 14.60 : + nIf01f C 159 123 1 32 4 1.55 3.00 10.88 5 1 19.00 25.63 .1.25 5.51 8 ~ ~, 2 30 179 45 6 0.25 2.50 10.50 14.25 19.00 25.63 7.00 15.23 5 8 4? MCn CaSC2 23 16 7 0 1.45 1.45 9.93 12.50 16.28 19.00 36.00 10.99 9,45 36 20! 16 0 0.35 1.38( ?.90 16.75 19.00 31.50 38.00 t4.75 t'.CE AB 59 361 23 0 0.35 1.45I 1.90 14.38 18.75 28.00 38.00 13.08 10.6CI Women ases ~ 47 25 22 0 0.30 1.70 3.40 18.50 ',9.00 26.00 38.00 14.20 10.4E 76 47~ 29 0 0.40 `:.15 4.13~ 17.80 19.00( 26.00 38.00 13.84 9.29~ AI) 123 72 511 0 0.30 ?.20 3.76! 18.15 19.00 26.00 38.00I 13.97 9.64 Ap C6s0f 70 ° Controls 112 ~Atl 182 41 2 0 fi7 45!!! 0 108 74 0 0.30 0.35! 0.301 1.70 1.20 1.45 2.00 14.25 19.00 19.50 3.10 17.50 19.00 27.00~ 2.55 16.50 19.00~ 26.00 38.00 38.00 38.00 12.94 14.11 13.67 10.09 9.87 9.93 UNtT€D ItlNGDOM Men Cases ~~ 3 ( 2 ~ 0 18.50 18.50 18.50 18.50 18.50 18.50 18.50 18.50 0.00 Controls 14~ 10 4 0 3.50 3.50f 17.50 19.001 35.00~ 37.00 37.00 20.85 12.27 All 17 12 5 0 3.50 3.50f 17.50 18.75 27.25 37.00 37.00 20.46 11.14 WOrt1Cn Ciies 23 17 6 0 4.50 8.50 17.50 17.50 18.50 23.00 45.00 18.38! 8.02 Controls 126 39 37 0~ 1.50 12.50 17.50 18.00 18.50 36.00 43.50 19.68'( 8.65 AM 149 106 43 0 1.50 12.50 17.50 17.50 18.50 35.00 45.00 19.471 8.53 At C35fi 26 19 ? 0 4.50 8.50 17.50 17.50 18.50 23.00 45.00 18.39 '.56 Controls ~ 140 99 1 41 0 1.50 9.50 17.50 I 18.50 19.00 36.50 1 43.50 19.80 9.01 1 1 A!1 166 118 48 0 1.50 9.50 17.50 18.25 18.50 36.00 45.00 19.57 6.78 2063593354

C®SCU Occasional smoking, Cumulative exposure (packs/Iifetime) ALI. CENTERS Levol of~posuro Cas oz Controls OR 11 95 h Ct 1 OR(21 955: C1 ( OR 3 957. CI OR 4) 95% CI OR(5) 95% CI E Non oxposed 473 1032 1.00 1.00 1.00 1.00 1.00 0<05CU<5 103 237 1.01 ( 0.74- 1.37) 1.09 ( 0.79- 1.51) 1.11 ( 0.73- 1.70) 1.03 ( 0.75- 1.40) 0.85 ( 0.59- 1.21) 5<OSCU<12 17 52 0.70 ( 0.38• 1.28) 0.70 ( 0.36- 1.36) 0.84 ( 0.38- 1.88) 0.88 ( 0.37• 1.27) 0.75 ( 0.38- 1.47) 12<OSCU d d d T 12 33 45 188 0.92 ( 0 44 0.45- 1.91) 1.07 ( 0 43 0.49- 2.35) 1.16 ( 47 0 0.41• 3.24) 1.05 ( 45 0 0.51- 2.17) 0.83 ( 0 40 0.33• 2.05)~ l Fzclu / a ren 1 . . . . . ALL CENTERS VYITH EDUCAT IONAL LEVEL AND TY PE OF RES IDENCE Non expoled 337 795! 1.00 1.00 1.00 1•00 1.00 F 0<OSCU<5 42 133 1.05 ( 0.69- 1.60) 1.06 ( 0.69- 1.61) 1.11 ( 0.73- 1.70) 1.10 ( 0.72- 1.68) 0.79 ( 0.48- 1.31) 5<0SCU<12 9 35 0.82 ( 0.37- 1.82) 0.83 ( 0.37- 1.84) 0.84 ( 0.38• 1.88) 0.77 ( 0.33- 1.79) 0.94 ( 0.41- 2,16) 12<0SCU 6 21 1.11 ( 0.40- 3.08) 1.10 ( 0.40- 3.05) 1.16 ( 0.41- 3.24) 1.14 ( 0.41- 3.17) 0.96 ( 0.25- 3.62) €xcludad1rrend 104 353 0.48 0.47 0.52 0.48 E 0.44 1 ALL CENTERS WTTN DIETARY DATA exposad Non 361 643 1.00 1.00 1.00 1.00 ) 1.00 0<OSCU<8 81 168 0.85 ( 0.60- 1.22) 0.93 ( 0.64- 1.35) 0.84 ( 0.51- 1.39) 0.86 ( 0.60- 1.24) 0.85 ( 0.59- 1.21) g<OSGU< 13 14 35 0.74 ( 0.38- 1.44) 0.72 ( 0.35- 1.45) 0.92 ( 0.40- 2.13) 0.69'( 0.35• 1.38) 0.75 ( 0.38- 1.47) 12<OSCU 8 16 0,88 ( 0.35- 2.16 j 1.16 ( 0.46- 2.96) 1.02 ( 0.27- 3.84) 0.90 ( 0.36- 2.24) 0.83 ( 0.33- 2.05) Exclurltd/rrind 45 194 0.51 0.52 0.52 0.51 E 0.46 FRANCE Non exposetl 0<0SCU<5 6<OSCU<12 12<OSCU 44 73 1.00 1.00 1.00 ~ 1.00 1.00 20 56 0.57 ( 0.30• i.09)1 0.74 ( 0.36- 1.51) 1.14 ( 0.45- 2.92) 0.57 ( 0.29- 1.11) 0.58 ( 0.30- 1.11)~ 8 12 1.05 ( 0.39- 2.82) 1.18 ( 0.39- 3.54) 1.57 ( 0.41- 5.98} 1.01 ( 0.37• 2.73) 1.07 ( 0.40- 2.89) ! € 5 10 0,78 ( 0.24- 2.55)~ 1.01 ( 0.28- 3.61) 1.06 ( 0.18- 6.30) 0.76 ( 0.23- 2.50) 0.75 ( 0.23- 2.47) 6zcluded/Trand 1111 0 0 0.92 EEE 0.93 0.90 0.98 0.97 ~ GERMANYI Non expossd 63 181 100 . 1.00 1.00 1.00 1.00 0<OSCU<s 9 ! 3T 1.02 ( 0.44• 2.38) 0.97 ( 0.39- 2.42) 0.89 ( 0.34- 2.32)i 1.08 ( 0.46- 2,53) 0.47- 2.63) 1.11 ( 3<03CU< 13 3J 7 1.07 ( 0.24• 4.79)I 1.33 ( 0.27- 6.45) 1.42 ( 0.30- 6.75)1 0.69 ( 0.12- 4.00) 1.17 ( 0.25- 5.43) 92<OSCU O f 3 i 0.00 ( 0.00•99.99) 0.00 ( 0.00-99.99) 0.00 ( 0.00-99.99) 0.00 ( 0.00-99.99) 0.00 ( 0.00-99.99) sxcludrd/Trand l 7 ll I 0.58 0.53 0.54 EEE 0.70 ` 0.56 GERMANY2 Non ®xposad 137 147 7.00 1.00 1.00 1.00 1.00 0<OSCU<S 4 11 0.43 ( 0.13- 1.42) 0.42 ( 0.13- 1.40) 0.42 ( 0.13- 1.40)i 0.43 ( 0.13• 1.42) 0.33 ( 0.09• 1.25) 5<O5CU<•12 0 3 0.00 ( 0.00-99.99) 0.00 ( 0.00-99.99) 0.00 ( 0.00-99.99) 0.00 ( 0.00-99.99) 0.00 ( 0.00-99.99) 12<OSCU 1 1 1.00 ( 0.06-17.65) 0.97 ( 0.06-17.01) 1.16 ( ~ 0.06-22.52) 1.00 ( 0.06•17.66) 1.03 ( 0.06-18.15) 5zcludod/rrand 0 ' 0.37 0.35 0.40 ( 0.36 0.37 GERMANY3 Non exposeo 0<09cu<s 5<08CU<12 Excludad/rrendl ITALY i Non exposed 0<OsCU<5 S<09CU<12 12<OSCU ,'!~xcludad/Trend 1.00 1.00 1.00 0.00 ( 0.00-99.99)0.00 ( 0.00•99.99)0,00 ( 0.00-99.99) 99.99 ( 0.00.99.99)199.99 ( 0.00.99.99)199.99 ( 0.00-99.99) 0.47 0.45 155 1•00 1-00 41 1.98 ( 0,88- 4.48) 1.79 ( 0.75- 4.25) 10 0.00 ( 0.00-99.99) 0.00 ( 0.00-99.99) 9I 0.00 ( 0.00-99.99) 0.00 ( 0.00-99.99) 8!!!I 0.28 0.31 ITALY 2 Non exposed 1s 0<05CU<5 2 5<OSCU<s12 0 12<OSCU 2 Exc1 udad/Trand 0 ITALY 3 146 17 3 5 2 Non exposed 15{ 0<0SCU<5 5<OSCU<12 01 12<OSCU 0 cxcluded/Trend 0! PORTUGALI 461 0 3 1 0 Non exposfo j 42 32 0<05CU<5 1 01 1 g<0SCU<12 ~ 2 2 12<o50U I 21 1 5zo1udad/Trendi 3! 3. PORTUGAL2 Non exposed 21 40 O<05CU<5 8 5<OSCU<12 1 11 12<0SCU 0 1 r',rcluded/Trendi 4 3 SPAIN 1.00 1.51 ( 0.28• 8.03) 0.00 ( 0.00-99.99) 5.20 ( 0.70-38.84) 0.15 1.00 1.16 ( 0.16- 8.67) 0.00 ( 0.00-99.99) 3.45 ( 0.37•32•43) 0.34 1.00 99.99 1 0.00-99.99) 0.00 ( 0.00-99.99) 0.00 ( 0.00-99.99) 0.54 1.00 0.00 ( 0.00-99.99)~ 0.38 ( 0.04- 3.38) 1.29 ( 0.11-15.64) 0.91 ~ 1.00 2.25 ( 0.58- 8.80) 2.21 ( 0.12-39.55) 0,00 ( 0.00-99.99) 0.81 1.00 2.10 ( 0.86• 5.10) 0.00 ( 0.00-99.99) 0.00 ( 0.00-99.99) 0.30 1.00 1.72 ( 0.20-15.03) 0.00 ( 0.00-99.99) 19.05 ( 0.88-99.99) 0.43 1.00 1.00 99.99 ( 0.00•99.99) 99.99 ( 0.00•99.99) 0.00 ( 0.00-99.99) 0.00 ( 0.00•99.99) 2.48 ( 0.00•99.99) 0.13 ( 0.00-99.99) 0.45 i 0.43 1.00 1.71 ( 0.37• 7.98) 1.12 ( 0.04-28.69) 0.00 ( 0.00-99.99) 0.62 ) i 1.00 0.00 ( 0.00-99.99) 99.99 ( 0.00•99.99) € 0.47 1.00 2.23 ( 0.97- 5.10) 0.00 ( 0.00-99.99) 0.00 ( 0.00-99.99) 0.28 1.00 1.24 ( 0.21- 7.15) 0.00 ( 0.00•99.99) 5.09 ( 0.69-37.73) 0.15 1.00 99.99 ( 0.00•99.99) 0.00 ( 0.00-99.99) 0.00 ( 0.00-99.99) 0.55 1.00 ' 0.00 ( 0.00-99.99) ~ 0.35 ( 0.04• 3.16) 99.99 ( 0.00-99.99) 0.95 f 1.00 1.99 ( 0.50• 7-98) 2.33 ( 0.13-42.27) 0.00 ( 0.00-99.99) 1 0.84 1.00 0.00 ( 0.00-99.99) 99.99 ( 0.00-99.99) 0.51 1.00 99.99 { 0.00-99.99) 0.00 ( 0.00-99.99) 0.54 Non oxposetl 57 123 1.00 1.00 1.00 1.00 t.00 0<OSCU<5 ~ 3 10 0.61 ( 0.15- 2.42) 0.68 ( 0.17- 2.77) 0.68 ( 0.16- 3.00) 0.69 ( 0.17- 2.81) 0.56 ( 0.14- 2.27) 5<OSCU<a12 0 2 O.QO j 0.00-99.99) ~ 0.00 ( 0.00-99.99)~ 0.00 ( 0.00-99.99) 0•00 ( 0.00-99.99) 0.00 ( 0.00-99.99) Ezcludad/rrendl 241 0.47 ~ 0.48 j 0.45 0.47 0.41 SWEDEN Non exposad ( 21 401 1.00 700 . 1.00 1.00 OtOSCU f€ <•5 45 61 1.58 ( 0.80• 3.13) 1 .61 ( 0.81- 3.20) 1.48 ( 0.75- 2.94) 1.55 ( 0.78- 3.07) 6<OSCU<12 2 9 0.49 { 0.09- 2.67) 0.53 ( 0.10- 2.93) 0.49 ( 0.09- 2.70) 0.50 (, 0.09- 2.80) 12<OSCU 2 2 2.54 ( 0.32-20.22) 2.67 ( 0.33-21.65) # 2.51 ( 0.31-20.12) 2.26 ( 0.28•18.12) cxcludad/rrendl 0 0 0186 0.94 ~ 0.91 ~ 0.84 UNITED KINGDOM txcludad/rrendl 26i 1401 (1) Modet Mdude sexx center, sex'center and age (2) Model indude sex, oenter, sex'cenler, age and proportion of residential type in the last 35 yrs (REUP) (3) Modoi indude sex, center, sex'center, age, propon on of residential type in the last 35 yrs (REUP) and educaGonal level (EDUC) (4) R{GdCf fficYude acx, ccrtfc~, sex'xnter, age and duration of exposure to Ifst A agents (OCLAY) (5) Model include sex, center, sex'eenter, age and frequency consumphon of vegetables (VFGE) Risk estimates - Occasional smoking

®SUD Occasionaf smoking. Duration (years) (non overiappina) ALL CENTERS Total Ex sed Unaxoosed Excluded Min P10 ° 01 ! Medlan j 03 P90 Max ~ Mean Std RSSn Ca30! 138 42 95 1 0.50 0.50 1.00 2,00 ! 10.00 20.00 44.00 6.95 11.0E Control! 617 154 3501 13 0.50 0.50 1.00 2.001 4.00 11.00 46.00 4.78 8.51 All 672 196 445 31 0.50 0.50 1.00 2.00I 4.50 12.00 46.00 5.24 9.13 YYOnlon Caso! 488 97 378 11 0.50 0.50 1.00 2.00 5.00 20.00 44.00 6.23 9.6E Controls 885 186 682 17 0.50 0.50 1.00 2.00 5.00 20.00 50.00 6.18 9.8: All 1520 283 1060 177 0.50 0.50 1.00 2.00 5.00 20.00 50.00 6.20 9.7E AN Cases 650 139 473 38 0.50 0.50 1.00 2.00 6.00 20.00 ' 44.00 6.45 10.0 Controls 1542 340 1032 170 0,50 0.50 1.00 2.00 5.00 16.50 50.00 5:54 9.2E AN 2192 479 1505 208 0.50 0.50 9.00 2.00 5.00 18.00 50.00 5.81 9.5' ALL CENTERS WITH EDUCATIONAL LEVEL AND TYPE OF RESIDENCE MOn CiS1i 89 14 0.50 0.50 1.00 3.00 5.00 1 10.00 10.00 3.82 3.63 COnttolE 456 119 328 11 0.50 0.50 1 00~ 1.00 4.00 10.00 46.00 4.16 7.29 Atl 682 133 4001 29 0.50 0.50 : 1 00 1.00 4.00 10.00 46.00 4.12 6.94 1MOnthn Ca3aS 383 59 315 9 0.50 0.50 1.00 2.00 7.00 25.00 40.00 6.43 9.9:; Controls 742 734 594 14 0.50 0.50 1.00 2.00 5.00 19.00 45.00 5.75 8.9+ AII 1274 193 909 172 0.50, 0.50 1.00 2.00 5.00 19.00 45.00 5.96 9.2! AfI Casa! 498 73 389 36 0.50 0.50 1.00 2.00 5.00 15.00 40.00' 5.93 9.1'.. Cont101s 1338 253 920~ 165 0.50 0.50 1.00 2.00 5.00 14.00 46.00 ~ 5.00 8.21 A11 1836 326 1309 201 0.50 0.50 1.00 2.00 5.00 14.00 46.00 5.21 8.4' ALL CENTERS WITH biETARY DATA Mon Cases 101 27 73 1 0.50 1.00 1.00 1.00 5.00 20.00 44.00 6.15 10.4( Controls 292 87 196 9 0.50 0.50 1.00 1.50 4.00 14.00 45.00 5.18 9.3' All 410 114 269 27 0.50 0.50 1.00 1:.25 4.00 14.00 45.00 5.41 9.5- Women Cases 382 79 294 9 0.50 0.50 1.00 1.00 5.00 21.00 44,00 6.511 10.2: Controls 624 147 463 14 0.50 0.50 1.00 1.00 5.00 24.00 50.00 6.27 10.3' A!( 1155 226 757 172 0.50 0.50 1.00 1.00 5.00 21.00 50.00 6.35I 10 2• A}I Cases 609 106 367 36 0.50 1.00 1.00 1.00 5,00 20.00 44.00 6.421 10.2. COntrols 1056 234II 659 163 0.50 0.50 1.00 1.00 5.00 19.00 50.00 5.871 9.9s All 9565 3401 9026 199 0.50 0.50 1.00 1.00 5.001 20.00 50.00 6.04 10 0: FRANCE Man Cases 14 6 8 0 0.50 0.50 1.00 1.00 3.00I 4.00 4.00 1.75 1.4 Conlrols 23 16 7 0 0.50 1.00 1.00 1.00 2.50I 25.00 ~ 39.00 5.72i 1a.9. All 37 22 15 0 0.50 1.00 1.00 1.00 3.00J 12.00 39.00 4.64 7 4- Woni9n CasCt 83 27 36 0 1.00 1.00 1.00 3.00 10.001 18.00 40.00 6.78 9 7_ s Controls 128 62~ 68 0 0.50 1.00 1.00 1.50 5.00 10.00 27.00 4.06 I Atl 191 891 102 0 0.50 1.00 1.00 2.00 5.00 14.00 40.00 4.89 7 1: All Cases 7 33 44 0 0.50 1.00 1 00 2.00 5.00 15.00 40.00 5.86 8,9" ConUols 151 78 73 0 0.50 1.00 : ~ 1 00 1.00 5.00 12.00 39.00 4,40 6 9. All 228 111 117 0 0.50 1.00 1.00 1.00 5.00 14.00 40.00 4.84 GERMANY 1 Man Casas" c18 3 15 0 1.00 1.00 1.00 3.00 10.001 10.00 10.00 4.67 4 1. Controls 0.50 0.50 1.00 3.00 7.00 14.00 2.62 'E 129 30 97 2 0.50 Al1 ! 147 331 112 2 0.50 0.50j 0.50 1.00 3.00 9.00 14.00 2.80 3 3' VYOntan 59 9 48 0.50 0.50 1.00( 1.00 2.00j 7.00 7.00 2.22 2 Controls 100 15 84 1! 0.50 0.50 0.501 1.00 3.00I 10.001 19.00 3.33 5 0 158 24 132 21 0.50 0.50 0.50 1.00 3.00i '.00 19.00 2.92 41 Aq fUl :~8 2 63 0.50 0.50 ';.00 1.50 4.00 7.00 10.00 ".83 '' l:aEm! 229 45 181 3 0.50 0.50 0.50 1.00 3.00 9.00 19.001 2.86 ' 3 81 ConUol! All ~OS 57 244 4 0.50 0.50 0.50 1.00 3.00 9.00 19.00 2.85 3 6 Men Cases 29 28 0 5.00 5.00 I 5.00 5.00 5.00 5.00 5.00. 5.00 Conlrols 65 3 56 0 0.50 0.50 2.00 2.00 10.00 22.00 22.00 6.28 ., . All 94 10 84 0 0.50 0.751 2.00 3.50 10.00 16.00 22.00 6.15 6.6' Wonlan Cases 113 4 109 0 0,50 0,50 0.50 0.50 0.75 1.00 1.00 0.63 0.2: Controls 98 7 91 0 0.50 0.50 0.50 1.00 6.00 36.00 36.00 6.93 13.0( All 211 11 200 0 0.50 0.50 0.50 0.50 4.00 6.00 36.00 4.64 90.51 . All E Cases Controls All 142 183 305 5 16 21 137 147 284 0 0 0 0.50 0.50 0.5 0 0.50 0.50 0.50 0.50 0.75 0.50 0.50 2.00 2.00 1.00 8.50 6.OOj 5.00 22.00 10.00 5.00 36.00 36.00 1.50 6.56 5.36 1.9 9.6' 8.7' GERMANY3 Mon Casaf 10 0 10 o I Controls 14 2 11 1 1.00 1.00 1.00 1.50 2.00 2.00 2.00I 1.50 0.7 Afl 24 2 21 1.00 1.00 1.00 1.50 •2.00 2.00 2.00 1.50 0,7 ~YOf11 00 I CBSOS 21 1 20 0 15.00 15.00I 15.00 15.00 15.00 15.00~ 15.00 15.00 . i COnlf01C 38 0 38 0 1 All 59 58 0 15.00 15.00 15.00 15.00 15.00 15.00 15.001 15.00 CasCS All 31 1 30 0 15,00 15.00 15.00 15.00 15.00 15.00 15.00 15.00 , Controia 52 2 I 49 ~ ': 1.00 1.00 1.00 1.50 2.00 2.00 2.00 1 1.50 0.7 Atl 83 3 79 1.00 1.00 1.00 2.00 15.00 15.001 15.00 6.00 7.8 ITALY 1 Man Cases 8 3 5 0 3.50 3.50 3.50 10.00 10.00 10.00 10.00 7.83 3.7 Controls 103 40 62 1 0.50 0.50 1.00~ 1.00+ 3.00 7.00 46.00 3.43 7.3 I All 111 43 67 1 0.501 0.501 1.00 2.00' 3.00 10.00 46.00 3.73 7.2 Womon Cas®! 32 9 23 0 0.50 0.50 0.50 1.001 4.00 10.00 10.00 2.72 3.1 Contlols '18 25 93 0 0.50 0.50 0.50 2.00 6.00 23.00 30.00 6.26 9.0 All 150j 34 116 0 0.50 0.50 0.50i I 1.50 5.00 20.00 30.00 5.32 8.0 AM Caso! 40 12 28 0 0.50 0.50 0.75 2.75 7.50 10.00 10.00 4.00 3.9 Conlr0l! 221 65 155 1 0.50 0.50 1.00 1.00 3.00 12.00 46.00 ~ 4.52 8.0 All 261 77 183 1 0,50 0.50 t.00 2.00 4.00j 10.00 46.00 4.44 7.5 2't?b3593298 Descriptive statistics - Occasional smoking

ciws Childhood 0-18 yrs, Weighted smoking parent years MEN ONLY j ToLaI ExOosed Unexposed Excluded Min P10 j 01 Median Q3 j P90 j Max Mean Std MCn C35QS 157 76 80 1 0.13 2.25 8.25 10.69 14.25 18.75 27.13 10.59 5.39 Controls 580 335 236 9 1 0.25 3.00 7.88 12.63 f 14.25 19.00 40.13 11.60 6.64 AJI 737 411 316 10 0.131 3.00 7.88 11.63 14.25 18.75 - 40.13 11.41 6.44' Womcn Csses 0 0 0 0 ~ ~ Controts ~ 0 0 0 0 AU 0 0 0 0 ! i AII 510 157 76 80 0.13 2.25 8.25 10.69 ':4.25 18.75 27.13 10.591 5.39 Controls 580 335 236 9 ~ 0.25 3.00 7.881 12.63 14.25 19.00 ~ 40.13 11.60 6.64 All 737 411 316 10 0.13 3.00 7.881 ':1.63 14.25 18.75 40.13 11.41 6.44 WOMEN ONLY Msn Cafes 0 0 0 0 ~ 2063593347 COnlrolf 0 0 0 0 ~ ~ IAII 0 0 0 0 ~ WOfOCn CiSf-3 550 344 198 8 0.25 4.13 8.25 13.13 14.25 18.63 40.13 11.78 6.22' Controls ~ 1076 716 344 16 0.25 3.50 8.25 13.81 14.25 17.50 35.00 11.94~ 6.20, AM 1826 1060 542 24 0.25 3.75 ^0.251 13.13 14.25 18.25 40.13 ':1.89 6.21' All CeseS 550 344 198 8 0.25 4.13 8.25 13.13 14.25 18.63 40.13 .1.78 6.22; CCnltolf 1076 716 344 16 0.25 3.50 8.25 13.81 14.25 1 17.50 35.00 11.94 6.20= All 1626 1060 542 24 0.25 3.75 8.25 13.13 14.25 18.25 40.13 11.89 6.21 POPULATION 9ASED STUDIES MCn (s3C3 91 55 35 1 0.13 1.88 6.38 8.25 13.13 15.75 27.13 9.36 5.481 444 Controls [ 266 169 9 0.25 2.75 7.13 ~ 9.81 14.25 17.75 40.13 10.85 6.30f AN 5351 321 ~ 204 10 0.13 2.63 7.13 9.38 14.25 17.50 40.13 10.59 6.19( WomCn CaSCS 287 5 16 117 5 0.25 3.38 7.13 6.25 14.25 14.75 39.25j 9.95 5.941 COntr0lf ~ 506 340 157 9 0.38 3.19 7.88 6.75 14.25 16.69 34.38 10.74 6.95! i AG 793 505 274 14 0.25 3.38 7.88 8.25 14.25 16.00 39.25 10.48 5.95? AIl Ci4Cf 378 220 152 6 0.13 3.06 6.75 ".25 14.06 15.13 39.25 9.80 5.82; Controls 950 606 326 18 0.25 2.75 7.75 9.38 14.25 17.50 40.13 10.79 6.10'1 All 1328 826 478 24 0,13 2.75 7.50 8.69 14.25 16.88 40.13 10.52 6.04' HOSPITAL BASED STUDIES MCn C7sCf 47 18 29 0 5.63 7.88 10.881 13.69 18.25 19.00 19.00 13.76 3.92 COntrolm 73 45 28 0 1.38 8.63 13.13 14.25 14.25 19.00 35.00 14.17 6.53 A11 120 63 57 0 1.38 8.63 10.88 14.25 14.25 19.00 35.00 14.06 5.88 WOfrien CesOf 199 132 64 3 0.38 4.13 8.63 14.25 14.25~ 16.50 28.38 12.19 5.27 COnIrGt 379 271 101 0.25 4.13 9.75 14.25 14.25 15.88 35.00~ 12.42 5.34: AU 678 403 165 10 0.25 4.13 9.38 14.25 14.25 16.25 35.00 1.2.34 5.31 AII Cases 246 150 93 3 0.38 4.75 9.38 14.25 14.25 18.50 28.38 12.38 5.14: Controls 452 3161 129 0.25 4.13 10.13 14.25 14.25 16.25 35.00 12.67 5.55- AIl 698 466~ 222 10 0.25 4.13 10.13 14.25 14.25 16.88 35.00 12.58 5.41;~ MOn I C2fCf 112 55 56 1 0.13 1.88 5.25 9.63I 14.25 19.00 20.88 10.44 5.41; ~ COntr0ls 406 228 173 5 0.25 2.75 7.88 11.13! 14.25 18.75 35.00 11.28 6.40 All 518 283 229 6 0.13 2.75 7.88 10.88I 14.25 18.75 35.00 11.11 6.22 ~WOR'.Cn 0126Cf 430 275 150 5 0.25 4.75 8.25 12.38 14.25 18.50 40.13 '.1.68 6.03 j COnU01f 810 525 273 12 0.25 3.38 8.25 13.13 14.25 17.50 34.38 11.60 5.94 A11 1240 800 423 17 0.25 3.759.25 13.13 14.25 18.06 40.13 11.63 5.97 All C9s0f 642 330 206 6 0.13 4.00 8.25I 11.63 14.25 18.69 40.13 11.48 5.95 CoNf018 1216 753 446 17 0.25 3.38 8.25, 13.13 14.25 18.00 I 35.00 11.50 6.08 All 1758 1083 652 23 0.13 3.50 8.25 12.50 14.25 18.38 40.13 11.50 6.04 AGE e55 YEARS Men Cases 57 31 26 0 1.13 4.75 8.25j 10.88 14.251 19.25 27.13 11.25 5.84 ContrO!8 172 100 72 0 0.25 3.75 7.88 j 11.63 15.25 19.00 40.13 12.30 7.45 Atl 229 131 98 0 0.25 4.13 8.25 I 11.00 15.25 19.00 40.13 12.05 7.09 Women Casos 138 82 55 1 0.38 6.38 8.25 14.25 14.25 19.00 39.25 13.08 6.32 Contr011 254 159 91 4 0.25 4.13 7.88 14.25 14.25 18.50 34.25 11.87 5.99 ~ Atl 392 241 146 51 0.25 4.50 8.25 14.25 14.25 19.00 39.25 12.28 6.12 A!I Ges@f 195 113 81 1 0.38 5.63 8.25 13.88 14.25 19.00 39.25 12.58 6.22 Controls 426 259 163 4 0.25 4.13 7.88 13.75 14.25 19.00 40.13 12.04 6.58 Afl 621 372 244 5 0.25 4.13 8.25 /3.75 14.25 19.00 40.13 12.20 6.47 AGE 55-Pr4 YEARS Men Casef ! 62 E 25 26 1 0.88 2.25 5.63 8.25 13.13 14.25 19.00 8.82 4.76 Conltolt 218 I `:18 92 6 0,25 2.75 6.75 9.19 ~ 14.25 15.13 33.25 ~ 10.51 ~ 6.29 All 268 j 143 118 0.25 2.75 5.63 8.88 14.25 14.501 33.25 10.21 6.07 WOn1Cn CS3Cf 176 115 58 3 0,25 3.50 8.25 11.63 14.25 19.00 40.13 11.56 6.51 ' Conirds 359 I 2501 102! 7 0.25 2.38 7.50 13.13 14.25~ 17.94 35.00 11.73 6.94 All ! 535 365 160 10 0.25 2.75 7.88 13.13 14.25 18.50 40.13 i1.68 6.83 All 228 Cases 140 84 4 0.25 3.44 7,88 9.88 14.25 18.56 40.13 11.07 6.39 575 Controls 368 194 13 0.25 2.63 7.31 t2.88 14.25 17.50 35.00 11.34j 6.76 All 803 508 278 17 0.25 2.75 7.50 51.63 14.251 18.381 40.13 11.27 6.65 AGE 65* YEARS Men GSfOf 48 20 28 0 0.13 4.63 8.50 13.131 14.25 18.88 19.00 11.77 S.iC~ Controlf 1921 117 72 3 0.25 2.63 8.25 14.25 14.25 18.38 35.00 1 12.09 6.16 All i 240 137, 100 3 0.13 2.63 8.25 14.25 14.25 18.50I 35.00 -- i2.05 -- 6.00 -- WOmron CASCf 238 147 85 4 0.25 3.88 8.00 12.25 14.25 16.001, 34.38 11.22 5.78 COMr01f 463 3071 151 5 0.88 4.75 8.25 ~ 13.88 14.25 16.88 34.38 12.15 5.66 All 699 454 __ 236 9 _ 0.25 _ 4.75 _ 8.25 13.50 14.25 16.2 _ 34.38 _ 11.85 _ 5.71 ~ j OnIf01f I, C 223 8 ` 0 2 1 4. 1 1 2 80 All 939 591 36 3 12 0.1 3 4.25 8.25 13.88 14.25 16.75 35.00 1 1.90 5.

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C1WN Chifdhood 0-18 yrs, Weighted number of smokers H13TOLOGICALLY CONFIRMED DiAGNOSIS Total ~ Exoosed Un6xoosed Exduded Min ( P10 01 Median ~ Q3 P90 1 Max ~ Mean Sid ( Men CaSCS 152 74 77 i 0.25 0.75 0.75 0.75 0.75 1.25 2.00 0.83 0.36 COnlras 580 335 236 9 0.25 0.50 0.75 0.75 1.00 1 1.25 2.50 0.84 0.36 Al1 732 409 313 10 0.25 0.50. 0.75 0.75 1.00 1.25 2.50 0.84 0.36 WINflCn Cases 531I 333 190 8 0.25 0.75 0.75 0.75 1.00 1.25 2.25 0.84 0.32 Conttols 0G7~ ; 716 344 16 0.25 0.75 0.75 0.75 0.75 1.25 ~ 2.25 0.84 0.32 AJI 6 1049 534 24 0.25 0.75 0.75 0.75. 1.00 1.25 2.25 0.84 0.32 Ap Cases 683 407 267 9 0.25 0.75 0.75 0.75 1.00 1.25 2.25 0.84 0.33 Controls 1656 1051 580 25 0.25 0.75 0.75 0.75 1.00 1.25 2.50 0.84 0.34 A!I 2339 1458 847 34 0.25~ 0.75 0.75 0.75 1.00 1.25 2.50 0.84 0.33 SQUAMOUS CELL CARCINOMA MCn C85C3 Controls All ~ 28 580 608 4 335 339 24 236 260 0 9 9 0.75 0.25 0.25 0.75 0.75 0.50 0.75 0.50 0.75 0.75 0.88 0.75~ 1.00 0.75 1.00 1.00 1.25 1.25 1.00 2.50 2.50 0.81 0.13 0.84 0.36 0.84 0.36 WofiCn CzsCs 97 59 37 1 0.25 0.75 0.75 0.75 1.00 1.75 ! 2.25 0.95 0.44 COnttols 1078 716 344 16 0.25 0.75 0.75 0.75i 0.75. ~ 1.25 i 2.25 0.84 0.32 All 1173 775 381 17 0.25 0.75 0.75 0.75 1.00 1.25 2.25 0.851 0.34 All Cases 125 63' 61 1 0.25 0.751 0.75 0.75 1.00 1.25 2.25 0.94 0.43 Contt0ls 1656 1051f 580 25 ~ 0.25 0.75! 0.75 0.75f 1.00 ~ 1.25 2.50~ 0.84 0.34 AN 1781 1114 641 26 0.25 0.75 0.75 0.75 1.00 1.25 2.50 0.85 0.34 SMALL CELL CARCINOMA MCn Cases 14 7 7 0 0.75 0.75 0.75 0.75 0.751 0.75 0.75 0.75 0.00 COnlras 580 335 236 9 0.25 0.50 0.75 0.75 1.001 1.25 2.50 0.84 0.36 All 594 342 243 9 0.25 0.50 0.75 0.751 1.00 1.25 2.50 0.84 0.35 wwnen Cases l 67 42 24 1 0.25 0.25 0.75 0.751 0.75! 1.00 1.25 0.74 0.22 Controls i 1076 716 344 16i 0.25 0.75 0.75 0.75f 0.751 1.25 2.25 0.84~ 0.32 , '.143 758~ 368 17 0.25 0.75 0.75 0.75f 0.75. 1.25 2.25 0.84 0.32 A11 Cases 61 49 31 1 0.25 0.25 0.75 0.75 0.75 1.00 1.25 0.74 0.20 i Controls 1656, 1051 580 25 0.25 0.75 0.75 0.75 1.00i€ 1.25 2.50' 0.84 0.34 All 1737 1100 611 26 0.25 0.75 0.75 0.75 1.00/ 1.25 2.50~ 0.84 0.33 ADENOCARCINOMA MCn Cases Controls AIl 60 560 660 44 35 335 236 379 271 1 9 10 0.25 0.25 0.25 0.25 0.50 0.50 0.75 0.75 0.75 0.75 0.75 0.75 0.75 1.00 1.00 1.25 1.00 1.2s 2.00 2.50 2.50 0.78 0.84 0.84 0.37 0.36 0.36 WCtT1Cn Cases 261 176 101 4 0.25 0.75 0.75 0.75 1.00 1.25 1.75 0.84 0.31I Controls 1076 716 344 16 0.25 0.75 0.75 0.75 0.75 1.25 2.25 0.84 0.32 All 1357 692~ 445 20 0.25 0.75 0.75 0.75 0.88 1.25 2.25 0.84 0.32 AII Cases 361 220 136 5 0.25 0.50 0.75 0.75 1.00 1.25 2.00~ 0.83 0.32 Controls 1656 1051 580 25 0.25 0.75 0.75 0.75 1.00~ 1.25 2.501 0.84 0.341 AR 2017 1271 716 30 0.25 0.75 0.75 0.75 1.00 1.251 2.50 0.84 0.33 OTHER Men f,iSCS 30 19 11 0 0.75 0.75 0.75 0.75 1.00 1.75 2.00 0.99~ 0.42 ~ Controts 580 335 236 9 0.25 0.50 0.75 0.75 1.00~ 1.25 2.50f 0.84 0.35 AN 810 354 247 9 0.25 0.50 0.75 0.75 1.00 1.25 f 2.50 0.85 ~ 0.361 wornEn Cases 86 56 28 2 0.25 0.75 0.75 0.75 0.75 1.00 1.75 0.82 0.25 Controls 1076 716i 344 16 0.25 0.75 0.75 0.75 0.75 1.25 2.25 0.84 0.32 ~ A11 1162 772 372 18 0.25 0.75 0.75 0.75 0.75 1.25 2.25 0.84 0.321 All 116 75 39 2 0.25 0.75 0.75 0 75 1.00 1.25 2.00 1 0.86 0.3 Controls 1656 1051 580 25 0.25~ 0.75 0.75 0.75 1.00 1.25 2.50 0. 0.84 J 34 1772 1126 619 27 0.25 0.75 0.75 0.75 `:.00 1.25 2.50 0.84i 0.33 a75'A OF LIFESPAN IN RURAL AREA OR INTERMEDIATE CITIES f 76 30 45 MC~1 C83e COnlf0;4 225 120 103 2 Afl 301 150 148 3 0.25 0.25 0.251 0.63 0.25 0.50 0.75 0.75 0.75 0.75 0.75 0.75 0.75 1.00 0.75 0.88 1.00 1.00 1.75 2.00 2.00 0.74 0.83 0.81 0.28 0.31 0.31 WomCn Ca5N3 237 140 94 3 0.25 0.75 0.75 0.75 1.00 1.00 2.25 0.85 0.29 Controls 462 290 169 3 0.25 0.75 1 0.75 0.75 0.75 1.25 2.25 0.84 0.34 Afl 699 430 263 6 0.25 0.75 0.75 0.75 0.75 1.25 2.25 0.84 0.32 Ali Cases 313 170 139 4 0.25 0.75 0.75 0.75 0.75 1 .00 2.25 0.83 0.29 Controls 687 410 272 S 0.25 0.75 0.75 0.75~ 0.75 1.25 2.25 0.84 0.33 All 1000 580 411 9 0.251 0.75 0.75 0.75 0.75 1.25 2.25 0.84 0.32 >75% OF LIFESPAN IN URBAN AREA MCtt Cases 48 33 15 0 0.25 0.75 0.75 0.75 1.00 1.75 2.00 0.89 0.43 Controls 257 155 96 6 0.25 0.50 0.75 0.75 1.00 1.25 2.50 0.85~ 0.37 AN 305 188 111 6 0.25 0.50 0.75 0.75 1.00 1.50 2.501 0.86~ 0.38 WCmCn Cases 196 137 55 4 0.25 0.50 0.75 0.75! 0.75 1.25 2.25 0.81 0.32 Controls 454 326 119 9 0.25 0.75 0.75 0.75 1.00 1.25 2.25 0.86 0.32 A}I 650 463 174 13 0.25 0.75 0.75 0.75 1.00 1.25 2.25 0.85 0.32 AIl CiSC3 244 170 70 4 0.251 0.50 0.75 0.75 0.75 1.25 2.25 0.82 0.35 Controls 711 481 215 15 0.25 0.75 0.75 0.75 1.00 1.25 ~ 2.50 0.86 0.33 All 955 651 285 19 0.25 0.75 0.75 0,75 1.001 1.25 2.50I0.85 0.34 1 2lJI.T~]57~? J"'1'Q Descriptive statistics - Childhood 0-18 years ~oa _ -

D1 UD Childhood 0-18 yrs, Duration (years) (non overiapping) ALl. CEN7ERS Total i Exposed I UnexRosed ! ExGuded Min R10 ` Q1 ~ Median 03 P90 Max Mean Std Men Cases 141 75 65 1 0.50 6.00 10.00 11.00 98.00 18.50 18.50 12,57 ! 5.1 Coritrol3 531 321 201 9 0.50 5.00 10.50 i5.00 18.50 18.50~ 18.50 13,49~ 5.31 A11 672 398 266 10 0.50 5.00 10.50 14.00 18.50 18.50 18.50 13.32 5.3 Women CaSCs 509 314 187 8 0.50 6.001 10.50 14.25! 18.50 18.50 18.501 13.37 5.2 ~ COntrOfs 1011 700 295 16 0.50 6.00 10.50 17.00( 18.50 18.50~ 18.50~ 14.27 5.1 AI1 1520 1014 482 24 0.50 1 6.00 10.50 17.00' 18.50 18.50 18.50 13.99 5.2 Ap C~.SC3 650 389 252 9 0.50 6.00 10.50 14.00 18.50 18.50 18.50 13.22 5.2 COnttOiS 1542 1021 496 25 0.50 6.00 10.50 17.00 18.50 18.50 18.50 14.02 5.2 AH 2192 1410 748 34 0.50 6.00 10.50 17.00 18.50 18.50 18.50 13.80 5.2 Men Cases 92 49 42 1 0.50 2.50 10.00 10.50 18.00 18.50 18.501 11.73 5.2~ ContrOis 470 290 171 9 0.50 5.00 10.50 13.75 18.50 18.50 18.50 l I 13.31 5.3t AIl 562 339 213 10 0.50 5.00 10.50 ?2.50 18.50 1 18.50 ?8.50 13.08 5.3•. WUTrCn C.iSM 406 258 140 8 0.50 6.00 10.00 10.50 18.50 18.50 18.50 12.91 5.2 Controls 868 616 239 13 0.50 6.00 10.50 17.00 18.50 ~ 18.50 18.50 14.25 5.1. AII 1274 874 379 21 0.50 6.00 10.50 17.00 18.50 18.50 18.50, 13.86 5.1 M C05C3 498 307 182 9 0.50 6.00 10.00 10.50 18.50 18.50 18.50 12.73 5.2 Controls 1338 906 410 22 0.50j 6.00 10.50 17.00 18.50 18.50 18.50 13.95 5.2 AIl 1836 1213 592 31 0.50 6.00 10.50 16.00 18.50 18.SOf 98.50 13.64 5.2 Men C95es Controls AN 104 306 410 58 185 243 45 118 163 1 3 4 1.00 1.00 1.00 3.50 5.00 5.00 10.00 10.50 10.50 10.50 10.50I 10.50f 16.00 18.50 18.00 18.50 18.50 18.50 18.50 18.50 18.50 11.76 4.8 12.58 5.0 12.38 5.0' Won1Cn Cases 405 250 149 6 0.50 6.00 10.50 10.50 18.50 18.50 18.50 13.03 5.0 Controls 760 532 211 7 1.00 6.00 10.50 17.00 18.50 18.50 18.50 13.98 5.0 All 1155 782 360 13 0.50 6.00 10.50 16.00 18.50 18.50 18.50 13.68 5.0 A!I Cases 509 308 194 7 0.50 6.00 10.00 10.50 18.50 18.501 18.50 12.791 5.0 Controls 1056 717 329 10 1.00 6.00 10.50 15.50 18.50 18.501 18.50I 5.1 1 3.62 A1! 1565 1025 523 17 0.50 6.00 f0.50 14.00 18.50 18.501 18.501 1 13.37 5.1 FRANCE Men Cases 14 4 10 0 10.00 10.00 12.00 /5.50 17.75 4B.50 18.50 54.87 3.7 Controls 23 17 6 0 11.00 11.001 16.00 18.5018.50 18.50 18.50 16.68 2.8 All 37 21 16 0 10.00 11.00 14.00 18.00 18.50 18.50 18.50 16.33 3.0 Women CaSaE 63 40 22 1 3.00 9.75 13.00 18.25 18.50 18.50 18.50 15.50 4.2 Cor1U01s 128 97~ 31 0 1.50 8.50 11.00 18.50/ 18.50 18.50 18.50 15.12 4.8 All 191 '37 53 1 1.50 8.50 12.00 18.50 18.50 18.501 18.50 15.23 4.6 AR CaSes 77 44 32 1 3.00 10.00 13.00 18.00 18.50 18.50 18.50 15.44 4.1 i Controls 151 114 37 0 1.50 9.00 12.00 18.50 18.50 18.50 18.50 15.35 4.6 All 228 158( 69 1.50 9.00 12.50 18.25 18.50 18,50 18.50. 15.38 4.5 GERMANYI Men Cases 18 11 7 0 1.00 2.50 8.001 10.50 15.00 18.00 18.50 10.32 5.5 COntfdS 129 75 ~ 53 ? 2.00 5.00 10.50 10.50 18.50 18.50 18.50 12.08 4.8 AII 147 86 60 1 1.00 4.50 10.00 10.50 18.00 18.50 18.50 71.85 4.9 WOn1C71 C9SCS 58 34 22 2 2.00 6.00 7.50 10.50 14.50 18.50 18.50 10.94 4.9 Conlras 100 '7 21 2 2.00 5.00 i 8.50 10.50 12.50 18.50 18.50 11.04 4.4 All 158 ':11 43 4 2.00 5.50 8.00 10.501 13.00 18.50 18.50 11.01 4.u' A11 CiSCS 76 Conlr0ls ~ 229 All ~ 305 45 152 197 29 74 103 2 3 5 1.00 2.00 1.00 4.50 8.00 ?0.50 S.OOI 10.OOI 10.50 5.00 8.50 10.50 14.50 18.50 18.50 17.00~ 98.50 18.50 17.001 18.501 18.50 10.79 11.55 11.38 5. 4.^ 4.7 GERMANY 2 MMI C35Q5 29 18 10 1 2.00 2.00 8.00 10.50 10.50 10.50 10.501 8.72 3.1 Controls 65 39 25 1 1.00 5.00~ 3.00 10.50 10.50 10.50 10.501 8.86 2.? AA 94 57 35 1.00 3.00 8.00 10.50 10.50 10.501 _10.50 _ _ 8.82 _ 2.8 WOrnCn Cases 113 61 52 0 1.00 6.00 10.00 10.50 10.50 10.50 10.50 9.45 2.2 Controls 98 59 38 1 7.00 3.00 9.00 10.50 10.50 70.50 ! 70.50~ 8.90 2.8 Atl 211 120 901 1 '..00 4.50 10.00 10.50 10.50 10.50 10.50f 9.18 '-' E AIl CBfEs 142 79 f2 1 1.00 5.00 10.00 10.50 10.50 10.50 10.50 9.28 2.E Controls 163 98 63 2 1.00~ 4.00 8.00 10.50E 10.50 10.50 10.50 8.88 2.E At! 305 `;77 125 3 1.00 4.00 9.00 10.50 10.50 10.50 10.50 9.06~ 2. E G€RMANY3 Men C4ses 10 Controls 14 An 24 Women CasCS 21 Controls 38 All 59 Alt Cases 31 Controls 52Afl 83 3 7 0 10.00 10.00 10.00 10.501 10.50 10.501 10.50 10.33I 0.2 6 4.00 4.00 5.00 10.00 10.50 10.501 10.50 8.36! 2.7 10 13 4.00 4.50 8.00 f 10.25 10.50 10.50 10.50 8.951 2.4 12 8 1 5.00 6.00 7.00 10.50 10.50 10.50 10.50 9.08 2.' 26~ 12 0 2.00 2.00 8.00 I 10.50 10.50 10.50 10.50 8.71 3.C 38 20 1 2,00 4.00 7.00 10.50 10.50 10.50 10.50 8.83 2.- 15 15 1 5.00 6.00 7.00 10.50 10.501 10.50 10.50 9.33! 1.e 33 18 2.00 4.00 8.00 10.50 10,50, 10.50 10.50 8.64J 2.~ 48 33 2 2.00 4.00 7.50 10.50 10.50 10.50 10.50 8.851 2.F ITALY 1 Mcn Cas®s 8 Controls 103 All ?11 6 70 76 2 28 30 0 5 5 14.00 1.00 1.00 14.00 5.50 6.50 18.00 18.50 11.00 18.00 71.25 16.00 18.50 18.50 18.50 18.50 18.50 18.50 I 18.50 18.50 18.50 17.67T 14.51 14.76 1.e °' 5.: WOrnen CSSCs i 32 21 9 2 0.50 1.00 4.00 17.00I 18.50 18.50 18.50 11.901 7.-. Contr018 118 92 21 5 1.001 6.00 14.75 18.50{ 18.50 18.50 18.50 15.54 S.' All 150 113 30 7 0.50 4.00 12.00 18.50 18.50 18.50 18.50 14.861 5._i A!1 Cases 40 27 11 2 0.50 1.00 7.00~ 18.00 18.50 18.50 8.50 18.50 j 13.18 .. Controls 221 162 49 10 1.00 6.00 12.00 18.50 18.50 1 18.50 15.09 5.: AH 261 189 60 12 0 10 0 4.50 17.50 18.50 18.50 18.50 18.501 94.82 5.: 21063593349 Descriotive statistics - Childhood 0-18 years

1U Childhood 0-18 yrs, Smoking parent years ALL CENTERS t.evel W exposure ` Cas es Cont rols 1 gR(1 95% Cl NE., c1uS<+19 480 1025 1,00 19<C1US<.31 941 387~ 0.85 ( 0.67- 1.09)1 37eC1US 20 705 0.53 ( 0.37- 0.90) £xcluded/Trendl 91 251 0.01 ~ €€€~ ALL CENTERS WITN EDUCAT IONAL LEV EL AN D TYP E OF RES IDENC .1 02-.1 04 (.2 08) E 0.14 f 0. 16 0. 15 OR(4) 95X CI OR(5 95% CI 1.00 1.00 0.88 ( 0.68- 1.13) 0.83 ( 0.62- 1.12) 0.54 ( 0.32- 0.93) 0.56 ( 0.28- 1.13) 0.01 ~ 0.02 NE., 01U5<19 323 773 1.00 1.00 1.00 1.00 1.00 19<C1US<31 T 91 283 0.91 ( 0.67• 1.25) 0.92 ( 0.67- 1.26)~ 0.93 ( 0.68• 1.28) 0.96 ( 0.70- 1.31) 0.92 ( 0.64• 1.31) 31<C1U5 10 83 0.45 ( 0.22• 0.91) 0.45 ( 0.22- 0.91) 0.44 ( 0.22- 0.89) 0.42 ( 0.20- 0.88) 0.40 ( 0.15- 1.05) £xcludid/Trendl ALL CENTER3 WRN DIETARY DATA 74 1991 0.01 0.01 ~ 0.01 0.01 ~ 0.01 NE., C1us<1a 382 742 1.00 1.00 1.00 1.00 1.00 19<C1U8<031 102 237 0.84 ( 0.63- 1.13) 0.89 ( 0.66- 1.20) 0.95 ( 0.67- 1.36) 0.85 ( 0.63- 1.15)1 0.83 ( 0.62• 1.12) 31<C1US 11 47 0.55 ( 0.27- 1.10) 0.52 ( 0.25- 1.07) 0.39 ( 0.15- 1.05) 0.57 ( 0.28- 1.15)~ 0.56 ( 0.28- 1.t3) Ercluded/Trend 14 30 0.04 0.04 0.05 0.03 1 0.04 ( FRANCE NE., C1US<19 19<C1US<31 31<clus 52 85 1.00 1.00 1.00 1.00 1.00 23 59 0.62 ( 0.34- i.14) 0.74 ( 0.38- i.44j 0.85 ( 0.36- 2.01) ~ 0.64 ( 0.34- 1.18} 0.62 ( 0.34- 1 .14) 1 7 0.19 ( 0.02- 1.65) 0.00 { 0.00•99.99) 0.00 ( 0.00•99.99) 0.18 ( 0.02• 1.59) 0.18 ( 0.02- 1.59) £xcluded/Trend 1 0 0.04 ( 0.03 0.04 ~ 0.04 0.03 GERMANYI NE.! C1US< 19 19<C1US<• 31 31<C7US ~ 63 180 1.00 1.00 1.00 1.00 1.00 10 ~ 42 0.76 ( 0.35- 1.67) 0.96 ( 0.42- 2.19) 1.04 ( 0.45- 2 41) 0.79 ( 0.36- 1.74) 0.87 ( 0.39- 1.93) ~ 1 4 0.87 ( 0.09- 8.67) 1.59 ( 0.15-17.27) 1.65 ( 0.15-18.54) 0.98 ( 0.10•10.08) 1.25 ( 0.11-13.61) £xcludad/Trand l 2~ 31 0.54 0.54 0.67 ~ 0.59 r 0.62 € GERMANY2 Ne ., C1US<19 19<C1US<31 31<C1US 128 154 1.00 1.00 1.00 1.00 1.00 12 6 2.34 ( 0.82• 6.65) 2.59 ( 0.89- 7•57)1 2.81 ( 0.94- 8.46) 2.33 ( 0.82- 6.66) 2.36 ( 0.83• 6.71) 1 1 1.44 ( 0.08•26.19) 1.39 ( 0.06-25.29) 1.08 ( 0.06-20.47) 1.43 ( 0.08-25.92) 1.49 { 0.08-27.29) £.tcl4ded/Trend 1 2 0.16 ~ 0.13 ~ NE., C1uS<19 19<C1US<31 £xcluded/rrendl 29 1 ITALY 1 N€., C1US<19 ) 19<C1US<31 31<C1US P £xcluded/Trandi ITALY 2 24_ 10~ 4+ 2~ NE., 1US<19 8 19<C1US<31 ~ 10 31<clus t 1~ £xclud.d/Trendl ITALY 3 0 N€., 01U5<19 19<C1US<31 31<C1US 0 £xclUded/Trend PORTUGAL 1 0 1 N€., C1US<19 34 19<C1U3<31 12 31<clus 3 £xc1 uded/Trend PORTUGAL 2 N€., C1US<19 19<C1US<31 31<clus l 01 £xcluded/rrend SPAIN NE., C1US<.19 ~ 19<C1U5<31 31<C1U8 Exc1 uded/Trend I SWEDEN N€., C1U5< 25 7 i a( 36 311 2 t.oo I 1.00 0.00-99.99)i99.99 ( 0.00-99.99)199.99 ( 0.00-99.99) 103 1.00 71 0.57 ( 0.25- 1.32) 37 0.37 ( 0.11- 1.16) 10! 0.06 107 50 14 1.00 2.63 ( 0.90- 7.66) 1.21 ( 0.13-11.42) 2 0.26 OR121 95% Ct (. pR(3) 95% Cl 1.00 1.Oo 0.89 ( 0.68- 1.16) 0.93 ( 0.68- 1.28) 0.01 0.99 0.99 1.00 ; 1.00 0.69 ( 0.29- 1.62)~ 0.76 ( 0.32- 1.84) 0.46 ( 0.14- 1.53) 0.50 ( 0.15- 1.70) 0.12 0.12 7.00 1.00 3.77 ( 1.08-13.22)1 1.89 ( 0.43- 8.25) 2.61 ( 0.24-28.59) 1.70 ( 0.12•23.85) 3*77 0.08 0.15 1.00 1•00 0.88 ( 0.22• 3.45) 0.64 ( 0.15- 2.83) 0.00 ( 0.00-99.99) 0.39 ( 0.00-99.99) 0.41 23 1.00 1.00 ~ 10 0.86 (, 0.29- 2.53) 0.84 ( 0.28- 2.49) 3 0.66 ( 0.12- 3.72) 1.02 ( 0.15- 6.93) 3 0.61 0.58 39 1.00 1.00 1.00 12 0.92 ( 0.31- 2.76) 0.50 ( 0.14- 1.71) 0.96 ( 0.32- 2.88) 2 0.86 ( 0.07-11.22) 1.06 ( 0.08-14.33) ~ 0.99 ( 0.08-13.03) 0 0.86 0.94 ~ 0.92 68 1.00 1.00 -i 1 00 1.00 1.00 77 0.70 ( 0.39- 1.28) 0.66 ( 0.35- 1.24)~ 0.72 ( 0.38- 1.37) 0.75 ( 0.41- 1.37) 0.68 ( 0.37- 1.24) 10 0.37 ( 0.08- 1.81) 0.31 ( 0.06• 1.56) 0.35 ( 0.07. 1.79) 0.35 ( 0.07- 1.76) 0.43 ( 0.09- 2.18)( 4 0.12 0.13 € 0.18 0.12 0.14 19 48 74 1.00 1.00 1.00 1.00  19<C1US< 31 17 ~ 32 0•80 ( 0.39- 1,63)I 0.77 ( 0.38- 1.57) 0.77 ( 0.37- 1.58) 0.76 ( 0.37- 1.56) 31<clus 5 6 1.34 ( 0.37- 4.85)Itt! 1.18 ( 0.32- 4.35) 1.42 ( 0.39- 5.13) 1.54 ( 0.42- 5.66) £xcludad/rrond l 01 0 ~ t 0.97 ( 0.81 ~ 0.97 0.99 ~ UNITED K)NGDOM N€., C1U5<19 24 114 1 00 19<C1US<31 ? 0..64 ( 0.07- 5.72) 8 18 0.17 ( 0.02- 1.75) 31<clus 1 1.00 1.00 1.00 1.00 0.66 ( 0.07- 6.00)I 0.68 ( 0.08- 6.19) 0.67 ( 0.07- 6.05) 0.71 ( 0.08- 6.34) 0.12 i, 0.01- 1.54)Ilf 0.11 ( 0.01- 1.43) 0.19 ( 0.02• 2.00) 0.15 ( 0.01- 1.62) c`xcluded/Trend 0 0 0.12 ¢ 0.09 ~ 0.08 ~ 0.1> i 0.11 ~ (1) Model k)ctude sax, canter, sex'canter and 9p® (2) Model ktctude sex, center, sox'eenter, ag® and proportion of residential type in the last 35 yrs (REUP) (3) Model hcludo sex, center, sax'center, age, propartion of residential type in the last 35 yrs (REUP) and educational level (EOUC) )4) Mode) indude sox, center, sex•eenter, ago and duration of exposure to list A agents (OCLAY) (5) Model Ine)udo sex, center, sex'canter, age and frequency consumption of vegetables (VEGE) 1.00 f 1.00 1 99.99 ( 0.00-99.99) 99.99 ( 0.00-99.99)~ E 0.99 0.99 € 1.00 0.67 ( 0.29- 1.57) 0.30 ( 0.08- 1.12) 0.06 1.00 2.72 ( 0.92• 8.01) 1.25 1, 0.13-11.98) ( ~ 0.24 Risk estimates - Childhood 0-18 years

01WN Childhood 0-18 yrs, Weighted number of smokers ALL CENTERS ToL3i Exoosed Unexposed l Excluded l.1in ' P10 01 Median 03 P90 ~ Max t Mean Std MCn CSSC3 141 75 65 1 0.25 0.75 0.75 0.75 0.75 1.25 2.00 0.84 0.3E Controls 531 321 201 9 0.25 0.50 0.75 0.75 1.00 1.25 ~ 2.50 0.85 0.3E AU 672 3961 266 10 0.25 0.50 0.75 0.75 1.00 1.25 2.50 0.84 0.3E Wo~rren cases 509 31a 187 8 0.25 0.75 0.75 0.75 0.75 1.25 2.50 0.83 0.31 Contr018 1011 700~ 295 16 0.25 0.75 0.75 0.75~ 0.75 1.25 2.25 0.84 0.32 All 1520 1014 482 24 0.25 0.75 0.75 0.75 0.75 1.25 2.50 0.84 0.32 All Cescf 650 388 252 9 0.25 0.75 0.75' 0.75' 0.75 1.25f 2.50 0.83! 0.32 C nVaf 6 ~ f f ~ f ~ A li 21 92 14~0 748 34 0.25 0.75 0.751 0.75 0.75 Z.25 2.50 0.84 0.32 ALL CENTERS WTTH EDUCATIONAL LEVEL AND TYPE OF RESIDENCE Mett CasCf 92 49 42 1 0.25 0.75 0.75 0.75 0.75 1.50 2.00 0.85 0.3E Controls 470 290 171 9 0.25 0.50 ~ 1 0.75 0.75 1.00 1.25 2.50 0.83 0.35 All $62 339 213 10 0.25 0.50 0.75 0.75 1.00 1.25 2.50 0.84 0.3E WOntetl CisCS 406 258 140 8 0.25 0.75 0.75 0.75 0.75 1.25 2.50 0.83 0.32 Controls 868 816 239 13 0.25 0.75 0.75 0.75 0.75 1.25 2.25 0.85 0.31 All 1274 874 379 21 0.25 0.75 0.75 0.75 0.75 1.25 2.50 0.84 0.32 Ap C35E3 498 307 182 9 0.25 0.75 0.75 0.75 0.75 1.25 2.50 0.83 3 0.3 1 Controls 1330 906 410 22 0.25 0.75 0.75 0.75 1.00 1.25 2.50 0.84 0.92 All 1836 1213 592 31 0.25 0.75 0.75 0.75 0.75 1.25 2.50 0.84 0.3z Men CBsef 104 58 45 1 0.25 0.25 0.75 0.75 0.75 1.75 2.00 0.84 0.4C Controls 306 185 118 3 0.25 0.75 0.75 0.75 0.75~ 1.25 2.50 0.84 0.34 A11 410 243 163 4 0.25 0.75 0.75 0.75 0.75~ 1.25 2.50 0.84 0.36 Wonten cases 405 250 149 6 0.25 0.75 0.75 0.75 0.75! 1.25 2.50 0.83 0.3C Controls 750 532~ 211 7 0.25 0.75 0.75 0.75 0.75 1.25) 2.25 0.84 0.31 All 1156 782~ 360 13 0.25 0.75 0.75 0.75 ~ 0.75 1.25 2.50 0.83 0.31 All C915of 509 308 194 7 0.25 0.75 0.75 0.75 0.75 1.25 2.50 0.83 0.32 Controls 1056 '17 329 10~ 0.25 0.75 0.75 0.75 0.75 1.25 2.50 0.84 0.32 All 1 565 1025 523 17 0.25 0.75 0.75 0.75 0.75 1.25 2.50 0.84/ 0.32 Men Casef Controls Alf 14 23 37 4 10 17 6 211 16 0 0 0 0.75 0.75 0.75 0.75 0.75 0.75 0.75 0.75 1.25 0.75 0.75 0.75 0.75 0.75 0.75 1.75 1.75 1.75 1.751 1.00 1.75 0.90 1.75~ 0.92 0. E 0.33 0.3E Women Casef 831 40 22 1 0.25 0.63 0.751 0.75 0.75 1.13 1.75 0.83 0.31, Controls 1281 97~ 311 , 0 0.25 0.25 0.75 0.75 0.75 1.00 2.25 0.78 0.3C Afl 191 137~ 53 1 0.25 0.25 0.75 0.75 0.75 1.00 2.25 0.79 0.33 All Cases :7 44 32 1 0,25 0.75 0.75 0.75 0.75 1.25 1.75 0.84 0.34 Controls 151 114 37 0I 0.25 0.50 0.75 0.75` 0.75 1.00 2.251 0.80 0.33 A11 228 158~ 69 0.25 0.50 0.75~ 0.751 0.75~ ?.00 2.25/ 0.81 0.34 GERMANYI Men cases Controls All 18 129 147 11 75 36 7 53 60 0 0.25 1 0.25 1 0.25 0.75 0.75 0.75 0.75 0.75 0.75 0.75 0.75 0.75 0.75 0.75 0.75 0.75! 1.00.I 1.00 1.751 0.80 2.501 0.81 2.50~ 0.81~ 0.35 0.33 0.33 Worrten _ CisGf 58 34 22 21 0.25 0.75 0.75 0.75 0.75 1.00 1.75 0.83 0.2E CCnttoif 100 7 21 2 1 0.25 0.75 0.75 0.75 0.75 1.00 1.75 0.84 0.2E All 1S8 11 43 i 4 0.25 0.75 0.75 0.75 0.75 1.00 ?.75 0.84 0.2- All CBfef 76 45 29 2! 0.25 0.75 0.75 0.75. 0.75 1.00 1.75 0.82 0.3C Controls 229 152 74 3 0.25 0,75 0.75 0.75 0.75 1.00 2.50 0.83 0.3C All 305 197 103 5 0.25 0.75 0.75 0.75 0.75 1.00 2.50 0.83 0.3C GERMANY2 MCn I cases Controls All 29 1B 10 ': 0.25 0.75 0.75 0.75i 0.75 2.00 2.00 0.88 O.ab 65 391 25~ 1 0.25 0.25 0.75 0.75I 0.75 1.00 1.75 0.78 0.25 94 57 35 2 0.25 0.50 0.75 0.751 0.75 1.00 2.00 0.81 0.33 Won10n Cases 113 61 52 0 0.25 0.75 0.75 0.75 0.75 1.25 2.25 0.87 0.31 Controls 98 59 38~ 1 0.25 0.75 ~ 0.75 0.75M 0.75 1.00 1.75 0.78 0.2: AII 211 120 90 0.25 0.75 0.75 0.75i 0.75 ^5 2.25 0.83 0.2' A8 Cases 142 79 62 1 0.25 0.75 0.75 0.75 0.75 1.25 2.25 0.87 0.3~ I Contraf ~ 163 98 63 2 0.25 0.75 0.75 0.75 0.75 1.00~ 1.75 0.78 0.2° All ' 3051 177 125 31 0.25 0.75 0.75 0.75 0.75 1.25 2.25 0.82 0.27 GERMANY3 MCn cases 10 3 7 0~ 0.75 0.75 0.75 0.75 0.75 0.75 0.75 0.75 0.0C COnIlOff 14 :' 6 1~ 0.25 0.25 0.75 0.75 0.75 0.75 0.75~ 0.68 0.1E A11 4 1 ~ ~ ~~ 10 13 1 0.25 0.50 0.75 0.75 0.75 0.75i 0.75, 0.70 0.16 Women cases ' 21 ® 121 8 1 0.25 0.25 0.50 0.75 0.88 1.00 1.25 0.711 0.3: ConUols 38 261 12 0 0.25 0.75 0.75 ~ 0.75 0.75 0.75 0.75 0.73 0.1c ~ AII 69 38 20 1 0.25 0.25 0.75 0.75 0.75 0.75 0.15 1.25 0.72 All Cases 31 15 15 1 0.25 0.25 0.75 0.75 0.75I 1.00 1.25 0.72 0.2t Controls 52 33 18 1 0.25 0.75f 0.75 0,75 0.75! 0.75 0.75 0.72 0.1: All 83 48 33 2 0.25 0.25I 0.75 0,75 0.75', 0.75 1.25 0.72 0.1£ ITALY I Man Cases 8 6 2 0 0.75 0.75 0.75 0.881 1.001 1.00 1.00 0.88 0.1- Controls 103fp 701 28 5 0.25 0.25 0.75 0.75 100 1.25 2.50 0.83 111! 76 30 5 0.25 0.25 0.75 0.75 1.00 1.25 2.50 1 _ 0.84~ 0,3: Women Cases 32 21 9 2 0.25 0.25 0.25 0.75 0.75 1.25 2.25 0.76 0.4'. Control3 118 92 21 1 5 0.25 0.50 0.75 0.75 1.00 1.50 2.00 0.901 0.3: Ah 1S0 '13 30 71 0.25 0.50 0.75 0.75 1.00 1.50I 2.25 0.88L_ 0.3: - --= AII C9sef 40 27 11 2 0.251- -0.25 0.75 - - 0.75 _ - - _ 1,00 1.25 2.25f - 0 79 0.4' Contrcls 221 162 49 10 0.25 0.50 0.75 0.75 1.00 1.50 2.50! 0.87 [ 0.3 All 261 189 60 ?2 0.25 0.25 0.75 0.75 1.00 1.25 2.50 - 0.86 _ 0.3' 2063593337

alws Childhood 0-18 yrs, Weighted smoking parent years ALL CENTERS Total Exposed UnexDosed Excluded M n P10 Q1 Median 03 € P90 Max ~ Mean I Std Men ses 141 `)5 65 1 0.13 2.25 8.25 10.501 14.25 18.75 27.13 10.54 1 5.411 Controls 531 321 201 9 0.25 3.00 7.88 11.63 14.25 18.38 40.13 11.50 ti 6.691 All 672 396 266 10 0.13 2.75 7.88 11.00 14.25 18.50 40.13~ 11.32 6.471 Womcn ses 509 314 187 8 0.25 3.75 8.00 11.63 14.25 16.25 39.25 11.13 5.81; Controls 1011 700 295 16 0.25 3.63 8.25 13.81 14.25 17.25 35.00 11.91 6.101 AIl 1520 1014 482 24 0.25 3.63 8.25 13.13 14.25 16.88 39.25 11.67~ 6.02 AII CmsCs 650 389 252 9 0.13 3.50 8.00 11.00 14.25 16.38 39.25 11.01 5.73 Contro(s 1542 1021 496 25 0.25 3.38 8.25 13.13 14.25 17.50 40.13 11.78 6.29 A11 2192 1410 748 34 0.13 3.38 8.25 13.13 14.25 17.50 40.13 11.57 6.15 ALL CENTERS WfTH EDUCATIONAL LEVEL D TYPE OF RESIDENC MCn Cases 92 48 42 1 0.13 1.88 7.88 8.25 13.88 18.25 20.88 9.94 5.171 ConUols 470 290 171 9 0.25 2.88 7.88 11.00 14.25 17.81 40.13 11.18 6.411 All 562 339 213 10 0.13 2.751 1 7.88 10.50 14.25 17.88 40.13 11.00 6.25 1 WORkl1 CaS@s 406 25B 140 8 0.25 3.50 7.88 10.50 14.25 15.25 39.25 10.79 5.72 Conlrotz 868 G16 239~ 13 0.38 3.75 L 8.251 13.56~ ~ 14.25 17.38' 35.00~ 11.97 6.11', All 1274 874 379 21 0.25 3.75 6.25 13.13 14.251 16.50 39.25 11.62 6.02 Afl CasM 498 307 182 9 0.13 3.38 7.88 10.13 14.25 15.75 39.25 10.65 5.64, Controls 1338 906 410 22 0.25 3.38 8.25 13.13 14.25 17.50 40.13 11.71 6.22 All 1836 1213 592 31 0.13 3.38 8.25 13.13 14.25 17.00 40.13 11.44 6.09 e1LL CENTERS WITH DIETARY DATA MCn Cases 104 58 45 1 0.88 1.88 7.88 8.25 93.88 18.25 27.13 9.89 5.43 COnlrCls 306 185 118 3 0.38 3.38 7.88 9.00 14.25 17.50 ~ 33.25 10.90 6.36 AJI 410 243 163 0.38 3.00 7.88 8.63 14.25 17.50 33.25 10.66 6,15 Women G.lses 1 405 250 149 6 0.38 4.13 8.00 10.75 14.25 15.56 34.38 10.78 5.30 Controls 750 532 211 7 0.38 4.13~ 8.25 13.13 14.25 15.88 i 35.00 11.69 5.98 All 1155 782 380 13 0.38 4.13 8.25 12.44 14.25 15.63 35.00 11.40 5,78 - Ak C9SOS 509 308 194 7 0.38 3.75 7.88 10.13 54.25~ 15.75 34.38~ 10.61I! 5.3_ Corllrols ~ 1056 717 329 10 0.38 3.75 8.25 12.63 14.25, 16.13 35.00, 11.49i 6.0s AIl 1565 1025 523 17 0.38 3.75 8.25 11.25 14.25 16.001 35.00 11.22i 5.88 FRANCE Men Casos 14 4 10 0 7.88 7.88 9.38 12.00 15.69 18.25 12.53 18.25 4.36 Controls 23 17 6 0 8.63 8.63 13.13 14.25 1 14.25 32.38 1 33.25 15.45 7.0: All 37 21 16 0 7.88 8.63 10.88 14.25 14.25 19.00 33.25 14.89 6 e' Women Cases 63 40 22 1 0.88 4.44 9.00 14.25 14.25 18.25 28.38 12.58 5.5c Controls 128 ~ 97 31 0 0.50 2.75 8.63 14.25 14.25 15.00 35.00 `1.99 All 1911 137 53 1 0.50 3.131 8.63 14.25 14.251 16.00 35.00 12.17 5 9: All Casas ~ 77 44 32 0.88 5.00 9.00 14.25 14.25 18.25 28.38 12.58 5 4; Controls 151 114 37 0 0.50 3.13 8.63 ?4.25 14.25 15.50 35.00 12.51 6.3~ All 228 158 69 0.50 3.38 8.63 14.25 14.25 17.00 35.00~ 12.53 6^~ GERMANY 1 Men Ceses 18 11 7 0 1.13 2.25 3.88 8.25 13.881 14.25 19.25 8.41 5•E Controls 129 75 53 1 0.88 3.75 7.13 8.25 14.25 15.25 21.88 9.87 4-: A11 147 861 60 0.883.38 6.75 8.25 14.25 15.25 21.88 9.68 4 e; WORien Cases 68 34 22 2 0.63 4.88 5.63 8.25 14.25 14.25 27.88 9.21 S 11 Controls 100 77 211 2 0.63 4.50 6.75 8.25 11.63 14.25 33.25 9.42 4 9' AlI 168 111 43 4 0.63 4.88 6.38 8.25 12.63 14.25 33.25 9.36 4 9, All Cases 76 45 29 2 0.63 3.75 5.63 8.25 13.88 14.25 27.88 9.02 ~. Controls 229 152 74 3 0.634.13 6.75 8.25 13.81 14.25 33.25 9.64 4 8: AU 305~ 197 103 5 0.63 3.75 6.38 8.25 13.88 14.25 33.25 9.50 4.8= 29 18 10 0.88 1.88 6.38 8.25 8.25 19.75 20.88 8.33 5.ta 651 39 251 1 0.38I 1.88 4.88 8.25 8.25 9.88 18.75I 7.18 94 57 35 2 0.38) 1.88 5.50 8.25 8.25 9.88 20.88 i 7.54 3.94 VJomcn C9Sef 113 61 52 0 0.38 4.88 8.25 8.25 8.25 11.25 18.88 8.42 3.2" Controls 98 59 38 1 0.38 2.25 6.50 8.25 8.25 ~ 9.88~ 19.25 7.36 3.1;: All 2111 120 90 11 0.38 3.38 7.88 8.25 8.25 10.94 19.25 7.89 3.23 Aq CisCs 142 79 62 1 0.38 3.50 7.88 8.25 8.25 11.88 20.88 8.40 3.7c Controls ~ 163 98 63 2 0.38 2.25 5.63 8.25 8.25 9.881 19.25 7.29 3.2C ~' All t 305 177 125 3 0.38 2.75 7.13 8.25 8.25 10.88 20.88 7.78 3.4< GERMANY 3 Men CisCS 10 3 7 0 7.88 7.88 7.88 8.25 8.25 8.25 8.25 8.13 0.2, Controls 14 7 6 1 1.36 ?.38 ) 3.38 7.88 8.25 8.25 8.25 6.25 2.75 All 24 101 13 1 1.38 2.38 6.38 8.06 8.25 8.25 8.25 6.81 2.4= Womcn Cases E 1 12 3 1 1.88 2.75 3.44 6.94 8.56EI 9:63 11.88 6.43 3.1c Contro!8 i 381 26 12 0 1.13 1.88 6.38 8.25 ~ 8.25 8.25 8.25 6.82~ .< ' AU €E 59 38 20 1.13 1.88 88 8.25 I 8.25 8.25 11.88_ 6.70 .6E A!! Cases j 31 15 75 1 1.88 2.75 4.13 8.25 8.25 9.63 11.88 6.77 2,92 Conlrol5 52 33 18 1 1.13 1.88 6.38 8.25 8.25 8.25 8.25 6.70 2.SC All ~ 83 48 33 2 1.13 `:.88 4.88 8.25 8.25 8.25 11.88 6.72 2.6' ITALY I idM1 CBSes 8 6 2 0 9.63 9.63+ 10.88 14.06 15.75 16.13 16.13 13.42 2.62 Controls 103 70 28 5 0.38 2.06 8.63 I 13.25 14.25 ~ 19.251 40.13 12.04 7.4( All 111 76 30 5 0.38 2.13 8.63 13.56 1a.25 19.00 40.13 12.14 7.1- WoriCrl Cases 32 21 9 0.25 0.38 3.38 9.381 74.25 23.75 39.25 10.61 9.7. Controls 118 Alt 150 92 113 21 30 5 7 0.75 0.25 2.63 2.13 9.00 7.88 14.25j 14.25f 16.79I 95.75 21.38 ' 21.SD 33.25 39.25 13.33 ! 12.83 6.4E 7.2' All Cis€s ~ 40 Controls 221 All 261 27 162 189 11 49 60 2 10 12 0.25 0.38 0.25 0.38 2.25 2.13 4.75 8.63 8.63 11.63 14.25 14.25 14.25I 5.38 55.13 23.75~ 20.00 ~ 21.25 39.25 0.13 40.13 11.23 2.77 12.55 8.6n 6.8t 7.1' . 4. V©.,~573J`'1'+.J DescriQtive statistics - Childhood 0-18 years

C_C1 UN Childhood 0-18 yrs, Number of smokers A11. C€NT€R3 Lw.lofauwun ( Casos ) Contnots_)_ OR(1) 95%CI ( OR(2 No sroKOr 252 496 1.00 1 aaoker 306 750 0.80 ( 2 s.okers 52 191 0.63 ( >3 sMokera 32 80 1.05 ( £XCludtd/Tr~nd j 9 25 0.24 ALL CENTERS WITH EDUCATIONAL LEVEL AND TYPE OF RESIDENCE No sswker I smoker 2 s.okors >3 snokers fxCludsd/Trsnd) 74 ALL CENTERS WITH DIETARY DATA No aewker 1 saoker 1.00 0.84 ( 0.64- 1.10) 0.59 ( 0•37- 0.92) 1.10 { 0.64- 1.91) 0.19 350 1.00 1•00 1•00 571 0,84 ( 0.64- 1.10) 0,84 ( 0.65- 1.11) 0.84 ( 0.64- 1.10) 153 0.60 ( 0.39- 0.94) 0.60 ( 0.38- 0.94) 0.59 ( 0.37- 0.92) 65 1,18 ( 0.69• 2.03) 1.18 ( 0.69- 2.03)~ 1.10 ( 0.64• 1•91) 199 0•52 0.53 0.44 OR(4) 95% CI OR(S) 95% CI 1.00 1 1.00 0.80 ( 0.64- 1.00)~ 0.77 ( 0.60- 0.99) 0.64 ( 0•44- 0.92) 0.64 ( 0.42- 0.97) 1.10 ( 0,67• 1.79) 1.24 ( 0.68- 2.27) 0.25 ~ 0.26 1.00 0•85 ( 0.64- 1.11) 0.62 ( 0.39- 0.97) 1.18 { 0.68- 2.06) ~ 0.54 1 1.00 0.83 ( 0.62- 1.10) 1 0.65 ( 0.39• 1.06) ~ 1.30 ( 0.66. 2.56) ; 0.54 189 320 1.00 1.00 ( 1.00 1.00 1.00 244 558 0.77 ( 0.60- 0.98) 0.81 ( 0.62- 1.04) O.H2 ( 0.62- 1.10) 0.77 ( 0.60- 0.99) 0.77 ( 0.60- 0.99)I saokors 2 40 116 0.62 ( 0.41- 0.94) 0.66 ( 0.43- 1.01) 0.63 ( 0.38- 1.04) 0.64 ( 0.42- 0.98) 0.64 ( 0.42- 0.97) >3 aslokars 22~ 32 1.23 ( 0.68- 2.25) 1.29 ( 0.70- 2.38) 1.24 ( 0.63- 2.45) 1.27 ( 0.69- 2.33) 1.24 ( 0.66• 2.2?)~ vxcluded/Trand 14 30 0.65 0.65 0.59 0.67 0.68 ( FRANCE No sswKe r 3z 37 1.00 1.00 I 1.00 1.00 1.00 1 sswkar 35 97 0.42 ( 0.23- 0.79) 0.65 ( 0.32- 1.32) 1.03 ( 0.40- 2.66) 0.41 ( 0.22- 9.77) 0.43 ( 0.23. 0.80) 2 sookors 8 13 0.68 ( 0.25- 1.89) 0.90 ( 0.30- 2.71) 1.81 ( 0.44- 7-35) 0.66 ( 0.24- 1.82) 0.70 { 0.25- 1.94) ~ .3 selOker3 4 0.30 ( 0.03- 2.84) 0.47 ( 0.05- 4.62) 0.00 ( 0.00•99.99) 0.30 ( 0.03- 2.83) 0.29 ( 0.03- 2.73) c'.rcludod/Trsnd 0 0.46 0.49 0.52 0.49 0.45 Gf.RMANY 1 No amwker I smoker 2 sewkers 29 74 1.00 1.00 1.00 ' 1.00 1.00 39 122 0.65 ( 0.35• 1.19) 0.66 ( 0.33- i.30) 0.64 ( 0.32- 1.29) 0.70 ( 0.37- 1.30) 0.68 ( 0.36- 7.28) 5 28 0.32 ( 0.11- 1.00) 0.41 ( 0.13- 1.35) 0.43 ( 0.13- 1.43) 0.34 ( 0.11• t•O6) 0.37 ( 0.12- 1.16) 3 >• aMOkers 2 1.73 ( 0.14-21,18) 99.99 ( 0.00-99.99) 99.99 ( 0•00-99•99) 2.17 ( 0.17-27.87) 3.45 ( 0.18-66.70) Exclud.d~Trsnd e 9 0.62 0.58 0.62 0.63 0.61 j GERMANY2 No smoker 1 smoker 2 smokers >3 saokers f:rc1udsd/Trsnd GERMANY3 62 63 1.00 1.00 ~ 1.00 1.00 1.00 ~ 62 80 0.79 ( 0.48- 1.30) 0.79 ( 0•48• 1.32)( 0.78 ( 0.46- 1.30) 0.78 ( 0.47- 1•29) 0.79 ( 0.48- 1.30) ; 8 13 0.65 ( 0.24- 1.76) 0.74 ( 0.27- 2.02) 0.70 ( 0.25- ?.94)( 0.65 ( 0.24- 1,75)' 0.66 ( 0.25- 1.78) ! 9 5 1.81 (, 0.56- 5.89) 1.73 ( 0.53- 5.84) 1.70 { 0.50- 5.72) 1.81 { 0.55- 5•92)~ 1.84 ( 0.57- 5.99) I 2 0.91 ~ 0.93 1 0•87 0.89 0.91 No smoKer 1 smoker 2 smokers >3 smokers 8xcluded/Trand 15 18 1.00 ( 1.00 1•00 1.00 1.00 12 33 0.47 ( 0.16- 1.42)I 0.46 ( 0.15• 1.38) 0.41 ( 0.12- 1.35) 0.59 ( 0.19- 1.83) 0.36 ( 0.11- 1.18) 2 0 99.99 ( 0.00-99.99) 99.99 ( 0.00-99.99) 99.99 ( 0.00-99.99) 99.99 ( 0.00-99.99) 99.99 ( 0.00-99•99) l 1 0 99.99 ( 0.00-99.99) 99.99 ( 0.00-99.99) ~ 99.99 ( 0.00-99.99) 99.99 ( 0.00-99.99) 99.99 ( 0•00-99.99) 1 i 1 0• 74 0. 74 ~ 0.71 0.67 0.72 ITALY 1 No smoker I smoker 2 sArokers >3 a®okers fkcluded/Tr®nd 11 49 1.00 1.00 1.00 1.00 18 86 0.80 (, 0.33- 1.93) 1.09 ( 0.42- 2.86) 1.10 ( 0.40- 3.00) 0.88 ( 0.35- 2.22) 4 45 0.33 ( 0•09• 1.15) 0.44 !, 0.12- 1.63) 0.44 ( 0.12- 5.65)' 0.33 ( 0.09- 1.18) 5 31 0.57 ( 0.17- i.94)1 0.87 ( 0.24- 3.20) 0.92 ( 0.24- 3•54)I 0.50 { 0.13- 1.86) 2 10 0.61 ~ 0.80 [ 0.80 1( 0.59 ITALY 2 No sawKer 1 smoker 2 smokers b ;7[ 1.00 1.00 1.00 1.00 ; 7 57 1.85 ( 0.56• 6.12) 3.31 ( 0.83-13.16) 1.55 ( 0.30• 8.12) 2.05 ( 0.60- 6.93)~ ~ 2 24 1.27 ( 0.22- 7.36) 1.68 ( 0.19-14.88) 0.82 ( 0.07- 9.78) 1.35 ( 0.23- 7.86) >3 smokers 4 13 4.90 ( 1.05•22,96) 7.82 ( 1.29-47.24) 2.87 ( 0.36-22.92) 5.76 ( 1.18-28.21)! Excludod/Trondi o 2 0.31 0.16 ~ 0.14 f 0.27 ( ITALY 3 No smoker 1 smoker 2 spokers >3 smokers Excludid/Trvnd PORTUGALt No sAoker 1 smoker 2 smokers >3 smokers Pxc1 uded/Trsnd PORTUGAL2 No sa»ker 1 smoker 32 smokers >3 smokers fxcl udad/Trrnd 19 1.00 261 0.66 ( 0.18- 2.40) 31 0.45 ( 0.04• 5.78) 2 0.00 (, 0.00.99.99) 01 0.33 151 1.00 17 0.79 ( 0.30• 2.08) 2 1.27 ( 0.19- 8.32) 2 0.30 ( 0.02- 3•73) 3 0.11 1.00 0.56 ( 0.14- 2.28) 0.41 ( 0.03- 5.42) 0.00 ( 0.00-99.99) 0. 33 1 00 0.34 ( 0.07- 1.70) 99.99 ( 0.00-99.99) 99•99 ( 0.00•99.99) 0.52 1.00 0.55 ( 0.14- 2.12) 0.45 ( 0.03• 5.91) 0.00 ( 0•00-99.99) 0.27 1.00 0.75 ( 0.28- 1.99) 1.27 ( 0.19- 8.38) 0.64 ( 0.03-11.81) 0.10 1.00 0.63 ( 0.13- 3.00) 0.65 ( 0.04-11.07) 0.00 (, 0.00-99.99) 0.33 `;7 26 1.00 1.00 1.00 14 23 1.00 ( 0.38• 2.59) 0.71 ( 0.24• 2.07) 0.92 ( 0.35- 2.46) 2 3 1.00 ( 0.14- 7.32) 0.78 ( 0.10• 6.10) ~ 1.06 ( 0.15- 7.74) ( 0.00•99.99) ( 0.00-99.99) 0 ( 0.00-99.99) 0 0 0.7T 1 0.74 ~ 0 6 SPAIN No spoker 1 smoker 2 smokers >3 smokers ;3 321 1.00 1.00 1.00 1.00 1.00 44 92~ 1.18 ( 0.55• 2.49) 0.97 ( 0.44- 2.13) 1.06 ( 0.47• 2.39) 1.16 1 0.54- 2.47) 1.15 1 0.53- 2.46)4 ' 22 0.70 ( 0.23- 2.07) 0.58 ( 0.19- 1.75) 0.71 ( 0.22- 2.22) 0.70 ( 0.23- 2.09) 0.72 ( 0•24- 2.18) 5 9I 1.26 ( 0.35- 4.58) 1.00 ( 0.27- 3.72) 1.10 ( 0.29- 4.18) 1.23 ( 0.33- 4.52) 1.52 ( 0.40- 5.71) d'.rcludod/Trtnd 2 4! 0.85 0.92 0.84 0.85 ~ 0.56 :VYEDEN No smoker 29 45 1.00 1.00 1.00 ( 1.00 i smoker 291, 48 0.92 ( 0.47- 1.79) 0.87 ( 0.44- 11.72) j 0.89 ( 0.45- 1.75) 0.84 ( 0.43• 1.67) 2 smokers 9 16 0.85 ( 0.32- 2.25) 0.74 ( 0.27- 2.00) 0.77 ( 0.28- 2.08) 0.85 ( 0.32- 2.27) >.3 anoksra 3j 3 1.73 ( 0.32- 9.33) 2.03 ( 0.36-11.30) ~ 1.72 ( 0.32• 9.25) 1.86 ( 0.34-10.21) Exctudsd/Trend 0 0 0.93 0.98 ~ 0.95 0.95 UNITED KINGDOM NO aROker 41 1.00 1•00 t.00 1.00 1.00 < smoker 17 69 1.39 { 0.52• 3,71) 1.29 ( 0.47- 3.53) 1.23 ( 0.44- 3.40)1 1.16 ( 0.43- 3.19) 1.47 ( 0.54• 3.99) 2 smokers 0 22 0.00 ( O.oo-s9.ss) o.oo ( 0.00-99.99) 0.00 ( o.oo-ss.ss) 0.00 ( 0.00-99.99) ~ 0.00 ( 0.00-99.99) >•3 sCdokera 2 a 1.50 ( 0.26- 8.76) 1.16 ( o.1S- 7.45) 1.07 ( o.ts• 7.04) 1.64 ( ~ 0.27• s.ao) 1.50 ( 0.26- 8.82) CxCluded/TrOndl 0 0 0.51 : 0.40 0.34 0.45 ~ 0.54 1.00 0.64- 0.99) 0.84 ( 0•44• 0.80) 0.64 ( 0.65- 1.70)! 1.19 ( ( 0.24 95% CI ( OR(3) 95% CI t4) Modei i0cWe sex, canter, sexbantar, age and duration of exposure to list A agents (OCLAY) (5) Model k ckudo sex, canter, sox'centor, age and frequency consumption of vegetables (VEGE) R' k oetimatoc r'hilrihnnri fl 1 A

C1WN Childhood 0-18 yrs, Weighted number of smokers MEN ONLY TOtaI Exoosed UnexROSCd Excluded Min P10 ~ Ql t.ledian 03 j P90 Max I Mean Std MCn Cazcs 187 76 80 1 0.25 0.75 0.75 0.75 0.75 1.25 2.00 0.84 0.36 Controls S80 335 236 9 0.25 - 0.50 0.75 0.75~ 1 1.00 1.25 2.50 0.84 0.361 All 737 411 316 10 0.25 0.50 0.75 0.75 1.00~ 1.25 2.50 0.84 0.36 wornCn Cascs 0 0 0 0 ~ Controls 0 0 0 0 ~ All 0 0 0 0 ~ ~ All OasCs 157 76 80 0.25 0.75 0.75! 0.75 0.75 1.25 2.00 0.84 0.3fi Controlf 580 335 236 9 0.25 0.50 0.751 0.75 1.00 1.25 2.50 0.84 0.36 A!1 737 411 316 10 0.25 0.50 0.750.75 1.00 1.25 2.50 0.84 0.36 WOMEN ONLY MCn Case3 ` Conlrola Alt 0 0 0f 0 ~ 0 0 0 001 00 0 ~ ~ W001Gf1 CdSCS 650 44 198 8 0.25 0.75 0.75 0.75! '<.00 1.25 2.50 0.85 0.33, Controls 1076 116 344 16 0.25 0.75 0.75 0.75' 0.75 1.25 2.25 0.84 0.32} All i 1626 1060 's42 24 0.25 0.75 0.75 0.75~ 1.00 1.25 2.50 0.84 0.33 Afl CisC3 550 344 198 8 0.25 0.75 0.75 0.75 1.00 1.25 2.50 0.85 0.33 Controls 1076 716 344 16 0.25 0.75 0.75 0.75 0.75 1.25 2.25 0.84 0.32 All 1626 1060 542 24 0.25 0.75 0.75 0.75 1.00 1.25 2.50 0.84 0.33 POPULATION BASED STUDIES Mon sG9 91 Controls 444 All 535 Woman C3sos 287 Controls 506 All 7931 55 266 321 35 169 204 1 9 10 0.25 0.25 0.25 0.25 0.50 0.25 0.75 0.75 0.75 0,75 0.75 0.75 0.75 1.25 1.00 1.25 1.00 1.25 2.00 2.50 2.50 0.82 0.83 0.83 0.39 0.36 0.36 165 117 5 0.25 0.75 0.75! 0.75 0.75 1.251 2.25 0.84 0.34 340 157 9 0.25 0.75~ 0,75 0.75 1.00~ 1.25 2.25! 0.85 0.31 505 274 14 0.25 0.75f I 0.75 0,75~ 1.00( 1.25 2.25f 0.85 0.32 An CesCf 378 2201 152 6 0.25 0.75 0.75 0.751 0.75 1.25 2.25 0.84 0.35 Controls 950 606 326 18 0.25 0.50 0.75 0.75I 1.00 1.25 2.50 0.84 0.33 A11 1328 826 478 24 0.25 0.75 0.75 0.75 1.00 ':.25 2.50 0.84i 0.34 HOSPITAL BASED STUDIES Man Cases 47 18 29 0 0.75 0.75 1 0.75I 0.75 1.00' 1.501 1.75 0.90 0.29 Controls 73 45 28 0 0.25 + 0.75 0,75 0.75 ~ 0 7 1. 25 2.00 2 . 0.84 0.34 0 A(1 120 63 57 0 0.25 0.751 0.75 0.75 . 00 1 .25 00 2 . 0.86 .32 0 WOfiCn Cases 199 132 64 3 0.25 0.50 0.75 0.75 0.75 1.00 1.75 0.79 0.26 Controls 379 271 101 7 0.25 0.75 0.75 0.75 0.75 1.00 2.25 0.79 0.28 All 578 403 165 10 0.25 0.75 0.75 0.75 0.75 1.00 2.25 0.79 ~ 0.27 A11 Cases 2461 150 93 3 0.25 0.75 0.75 0.75 0.75 1.00 1.75~ 0.81 0.26 Controls 452 316 129 7 F 0.251 0,75 0.75 0.75 1 0.75 1.00 2.25 0.80 0.29 All 698 466 2221 t0 0.25 0.75 0.75 0.75 0.75 1.00 2.25 0.60 0.28 wITHOUT OCCASIONAL SMOKERS MOn 'CJ6CS 112 55 56 1 0.25 0.75 0.75 0.75 0.75 1.50I 2.00 0.86 0.37 ! Controls ~ 406 228 1731 5 0.25 0.50 0.75 0.75 1.00 1.25 ! 2.00 0.841 0.34 All 518 283 229 6 0.25 0.50 0.75 0.75 1.00 1.25I 2.00 0.85 0.34 WOnfOn Cases 430 275 150 5 0.25 0.75 0.75 0.75 i.00II 1.25 2.25 0.841 0.32 controls 8101 525 273 12( 0.25 0.75 0.75 0.75 0.75~ 1.25 2.25 0.83 0.3C AU 1240 800 423 17 0.25 0.75 0.75 0.75 0.75 ?.25 2.25 0.83 0.31 All CisQS <4a-i-330~ 206 6 0.25 0.75 0.75 0.75 1.00 1.25 2.25 0.85 0.33 Contrcls /216 753 446 17 0.25 0.75 0.75 0.75I 1.00 1.25 2.25 0.83 0.31 All 1 1 1758, 1083 652 23 0.25 0.75 0.75 0.75 1.00 1.25 2.25 0.84 0.32 MM C85Ca ~ 1.'Oillroi& An 57 172 229 31 100 131 26 72 98 0 0 0 0.25 0.25 0.25 0.75 0.50 0.75 0.75 0.75 0.75I 0.75 0.75 0.75 ?.00 1.00 ':.00 1.75 1.50 1.75 2.00 2.50 2.50 0.98+ 0.90 0.92 0.45 0.42 0.43 WonIDn Cases 138 82 55 0.25 0.75 0.75 0.75 1.00 1.251 2.25 0.87 0.33 Controls 254 159 91 4 0.25 0.50 0.75 0.75 1.00 1.25 2.00 0.86 0.35 AI1 392 241 146 5 0.25 0.75 0.75 0.75 1.00 1.25 2.25 0.86 0.34 AIl CasCf 195 113 81 1 0.25 0.75 0.75 0.75 1.00 1.50 2.25 0.90 0.37 Controls 426 259 163 4 0,25 0.50 0.75 0.75 9.00 1.50 2.50 0.87 0.3£ All 621 372 244 5 0.25 0.75 0.75 0.75 1.00 1.50 2.50 0.88 0.3E AGE 5-G4 YEARS MM CasCf 9 52 25 26 1 0.25 0.25 0.75 0.75 0.75 1.00 1.00 0.70 0.22 Controls C 216 118 92 6 0.25 0.25 1 0.75 0.75 0.75 1.00 2.00 0.79 0.31 NI 268 143 1187 0.25 0.25 0.75 0. 75 0.75 1.00 2.00 0.78 0.3- WOn1Cn C9s€s 175 115 58 3 0.25 0.75 0.75 0.75 1.00 1.25 2.25 0.87 0.3< ConUO+f 359 250 1027 0.251 0.75 0.75 0.75 1.00 1.25 2.25 I 0.85 0.3c 9 835 365 160 10 0.25 0.75 0.75 0.75 1.00 1.25 2.25 0.86 0.3- AI Cases 228 140 64 41 0.25 0.75 0,75! 0.75 1.00 1.13 2.25 0.84 0.3: Controls 575 368 194 13 0.25 0.5 0 ' 0.75 0.75 0.88 1.25 2.25 4.83 0.3~ 803 508 278 17 0.25 0.5 01 i 0.75 0.75 1.00 1.25 2.25 0.84 0.3. AGE b5+ YEARS MCn Cms~f 48 20 28 0 0.25 0.50 0.75 0.75 0.75 1.00 ":.50 0.78 0.2E Conuols 192 117 '2 3 0.25 0.50 0.75 0.75 1.00 i.25! 2.00J 0.851 0.3: All 240 137 100 3 0.251 0.50 0.75 0.75 1.00 1.25 2.00 0.84 0.35 wortsan Cas~s 236 147 85 4 0.25 0.50 0.75 0.75 0.75 1.25 2.50 0.82 0.31 Controls 483 307( 151 5 0.25 0.75 0.75 0.75 0.75~ 1.25 2.25 0.83 0.25 All 699 454 236 9 0.25 0.75 0.75 0.75 0.75 1.25 2.50 0.82 0.3( A1) CiSAa 284! 167 i13 4 0.25 0.50 0.75 0.751 0.751 1.25 2.50 0.81 0.3 Controls 655 424 223 8 0.25 0.75~ 0.75 0.75 0.75 1.251 ~ 2.25 0.83 0.3: AII 1 939 591 336 12 0.25 0.75 0.75 0.75 1.25( 0.75 2.50 0.83 0.3

E _S1TP Spouse, exposure to different tobacco products OR(1) 95% C! { OR(2) 95% C! 1.00 1.00 1.11 ( 0.88- 1.40) 1.11 ( 0.87- 1.43) 0.84 ( 0.41- 1.73) 0.64 ( 0.29- 1.43) 1.27 ( 0.81- 2.01) 1.28 ( 0.80- 2.04) ALL CENTERS V1n'TH EDUCATIONAL LEVEL AND TYPE OF RESIDENCE Non expo3oG -- - 187 Only cigarette 178 Never cigarotte 8 Cigarette + other 28 €xcludtd/Tr.nd .97 ALL CENTERS VYrfH DIETARY DATA 620 1.00 377 1.10 ( 0.82• 1.47) 24 0.64 ( 0.27- 1.49) 41 1.23 ( 0.71- 2.13) OR(3) 95% CI lO")_ 95% C! ( OR(5) 95% CI ( 1.00 1.00 1.00 ( 0.80- 1.42) 1.13 ( 0.89- 1.43) 1.06 ( 0.81- 1.39) ( 0.28• 1.55) 0.94 ( 0.45- 1.95) 0.87 ( 0.42- l 1.81) ( 0.69- 2.09) 1.27 ( 0.80- 2.02)~ 1.26 ( 0.78- 2.04)1 1.00 1.00 ( 0.80- 1.42) 1.11 ( 0.83- 1.49) 1.15 ( 0.83- 1.58) ( 0.28• 1.55) 0.72 ( 0.31- 1.71) 0.69 ( 0.29• 1.63) ( 0.69- 2 09) 1.21 ( 0.69- 2.11) 1.22 ( 0.69- 2.18) 1.06 0.66 1.20 1.00 1.06 0.66 1.20 276 € NOn e%p03ftl 231 534 1.00 1.00 1.00 1.00 1.00 Only ciqarette 191 326 1.07 ( 0.82• 1.40) 1.10 ( 0.84- 1.4 6) 1.09 ( 0.79- 1.51) 1 1.08 ( 0.82- 1.42) 1.06 ( 0.81- 5.39) Never cigarette 12 26 0.86 ( 0.41- 1.77) 0.66 ( 0.30- 1.48) 0.71 ( 0.30- 1.68) 0.95 ( 0.46- 1.99) 0.87 ( 0.42- 1.81) Cigarette + other 38 51 1.27 ( 0.79• 2.05) 1.27 ( 0.78• 2.08) 1.17 ( 0.65- 2.11) l 1.26 ( 0.78- 2.04) 1.26 ( 0.78- 2.04)1 uded/Trrnd Excl 37 .'r9 ~ FRANCE Non exposea 39 ss 1.00 1.00 1.00 ( 1.00 1.00 Only cigaratt. 32 69 0.82 ( 0.44- 1.54) 0.70 ( 0.34- 1.42) 0.76 ( 0.31• 1.89) ) 0.80 ( 0.42- 1.51) 0.81 ( 0.43- 5.52) Never oigarette 3 7 0.74 ( 0.17- 3.17) 0.19 ( 0.02- 1.72) 0.24 ( 0.02- 2.54) ( 0.74 ( 0.17- 3.14) 0.71 ( 0.16- 3.04) Cigarette + other 3 10 0.53 ( 0.13• 2.13) 0.34 ( 0.06• 1.79) 0.00 ( 0.00-99.99) 0.54 ( D.13- 2.16) 0.51 ( 0.13- 2.05) Eroluded1rrond 0 0 ~ GERMANYI Non oxposotl 34 153 1.00 1.00 1.00 1.00 1.00 Only cigarette 27 56 1.38 ( 0.71- 2.69) 1.52 ( 0.73- 3.18) 1.44 ( 0.69- 303) . 1.41 ( 0.72- 2.77) 1.53 ( 0.77- 3.01) Never cigarette 3 4 1.75 ( 0.35- 8.82) 1.86 ( 0.36- 9.63) 1.91 ( 0.38- 9 .71) 2.73 ( 0.48•75.38) 2.00 ( 0.39•10.12) Cigarftta + other 11 16 1.50 ( 0.59- 3.82) 1.58 ( 0.58- 4.31) 1.61 ( 0.59• 4.40) 1.39 ( 0.53- 3.64) 1.57 ( 0.61- 4.06) ~clud.d/rr.nd~ °~ 0 GERMANY2 Non axpasaa Only cigarette xcludOd/Trond NOVar cigarette Cigarette + other E CSQaretta + other GERMANY3 Non axpOS9a Only ciqaretto Nevor Gigarttte Excludsd/Trand PTALY I 6' 98 1.00 1.00 1.00 t.oo 1.00 65 5 3 1.22 ( 0.70- 2.12) 1.17 ( 0.67• 2.Oa) 1.10 { 0.62- 1.93) 1 1.22 ( 0.70- 2.11) 1.19 ( 0.69- 2.06) 2 4( 0.47 ( 0.08- 2.74) 0.21 ( 0.02- 1.98) 0.24 ( 0.02• 2.31) 0.47 ( 0.08- 2.73) 0.47 { 0.08• 2.77) 9 8f 1.08 ( 0.37- 3.14) 1.02 ( 0.35- 2.97) 0.95 ( 0.32- 2.80)~ 1.07 ( 0.37- 3.12) 1.09 ( 0.38- 3.17) i 0 !0 1 22 35 1.00 1.00 1.00 1.00 1.00 € 7 14 0.83 ( 0.26- 2 62) 0.79 ( 0.24- 2.67)1 0.52 ( 0.14- 1.90) 0.86 ( 0.26- 2.89) 0.75 1 0.23- 2.44) ~ 1 2 0.84 ( 0.06-11.43) 0.72 ( 0.04-13.09) 0.39 ( 0.02- 8.28) 1.27 ( 0.08-19.68) 0.54 ( 0.04- 7.80) ? 1 1.70 ( 0.09-30.98) 1.68 ( 0.09•30.64)~ 1.16 ( 0.06-21.55) 2 50 ( 0.12-50.31) 1.81 ( 0.10-33.98) ~ 0 0 1 ~ Non exposed 16 123 1.00 1.00 1.00 1.00 E Only cigarette 22 92 0.98 ( 0.44- 2.22) 1.26 ( 0.54- 2.98) 1.10 ( 0.46- 2.62) 1.27 ( 0.54- 3.02) Cigarette + other ~ 2 5 1.39 ( 0.23- 8.55) 1.90 ( 0.30-12.15) 1.61 ( 0.25-10.46) 1.72 ( 0.27-10.79) Excluded/Trvndl 0~ 9 ~ ITALY 2 Non exposed Only cigarette New r cigarette CiQarottf + other Excludsd/Trend ITALY 3 Non exposed Only cigarette 10 106 1.00 ! 1.00 € 1.00 1.00 t 9 63 i 0.55 ( 0.18- 1.65)1 0.49 ( 0.14- 1.67)1 0.56 { 0.12- 2.58) 0.53 ( 0.18~ 1.58) 0 1 0.00 ( 0.00-99.99) 0.00 ( 0.00•99.9s)'I 0.00 ( 0.00-99.99) 0.00 ( 0.00•s9.9s) 0 2 0.00 ( 0.00•99.99)I 0.00 ( o.oo-s9.ss)( 0.00 ( 0.00 -99.99) 0 4 23 1.00 1.00 1.00 1.00 1.00 12 26 1.94 { 0.47- 8.07) 1.76 ( 0.39- 7.93) 0.84 ( 0.16- 4.48) 1.75 ( 0.40• 7.58)' !!€ 2.93 ( 0-58-14.77) €zc1 udod/Tr.nd l 0 ( ' E f ~ ! PORTUGAL 1 Non expoaea 29 25 1.00 E 1.00 ~ Only cigarette 20 ~ 14 1.63 t• 0.63- 4.21) ~ 1.58 ( 0.61- 4.09) Excluded/Trtnd~ ~ ~ ~ I ! € PORTUGAL2 Non exposed 16 38 1.00 1.00 1.00 Only cigarette 18 151 5.82 ( 1.61-21.09) 3.62 ( 0.87-14.98) 5.42 ( 1.49-19.75)~ €xcluded/Trend 1 0 ~ SPAlN Non 0%p03etl 23 50 1.00 1.00 1.00 1.00 1.00 Only cigarette 28 77 0.77 ( 0.37• 1.58) 0.83 ( 0.39- 1.78) 0.81 ( 0.37- 1.78) 0.79 ( 0.38- i.64) 0.73 { Never c.garet;e 7 0.70 ( 0.13• 3.84) 0.66 { 0.12- 3.65) 0.55 ( 0.09- 3.25) 0.84 ( 0.15• 4.80; 0.77 ( + other Cigarette 6 7 1.76 ( 0.51• 6.11) 1.73 ( 0.49- 6.14) 1.70 ( 0.47- 6.06) 1.83 ( 0.53- 6.38) 2.18 ( cxcluded/Trand !2 18 € SWEDEN Non exposed Only cigarette Never cigarette Cigarette + other I. :xcludad/Trand! UNITED IUNGDOM Non oxposoo 6 €xcluded/Trendl 181 ,1) Model utdudo sex, center, sex'center and age 60 1.00 ! 1.00 1.08 ( 0.55• 2.14) 1.08 ( 0.54- 2.15) I 0.61 ( 0.05- 7.37) 0.60 ( 0.05- 7.32) 1.81 ( 0.60• 5.50) 1.74 ( 0.57• 5.31) 1.00 .00 80 1.00 (2) Model include sex, csnler, sex'csnter, age and proportion of residential type in the last 35 yrs (REUP) (3) Model ndudG sex center, aex'cenler, age, proportion of residential type in the last 35 yrs (REUP) and educational level (EDUC) (4) ModC( (nC(udo scx, csntor, SeX•center, age and duration of exposure to list A agents (OOLAY) (5) Model Include sex, center, sex•center, age and frequency consumption of vegetables NEGE) 0.35- 1.53) 0.13- 4.42) 0.61- 7.85) i 1.00 1.00 1.11 ( 0.56- 2.19) 1.08 ( 0.54- 2.15) 0.66 ( 0.06- 8.03) 0.83 ( 0.07-10.34) 1.83 ( 0.60- 5.56) 1.96 ( 0.63- 6.04) 1.00 1.00 Risk estimates - SDOu-se

Childhood 0-18 yrs, Duration (years) (non overlapping) PENONLY Lavet of ex osuro Cases ( Controls Non axposed 0<C1UD<17 54 17<C1U0 21 fxcluded/rrendl 1 WOMEN ONLY 9 Non axpos.d 187 295 1.00 1,00 ; 1.00 1.00 1.00 0<C1UD<17 181 354 0.78 ( 0.59- 1.03) 0.82 ( 0.61• 1.09) 0.84 ( 0.61- 1•16) 0.78 ( 0.59- i.02)~ 0.77 ( 0.57- 1.05) 17<C1U0 1331 346 0.77 ( 0.57• 1.03) 0.78 ( 0.57- 1.08) 0.79 ( 0.54- 5.15) 0.77 ( 0.57- 1.04) 0.76 ( 0.53- 1.08) F Excludld/Trend B 16 0.05 ~ 0.06 0.05 0.05 ~ 0.06 POPULATION BASED STUDIES Non oxpo3ad 152 32s 1.00 1.0o t t.00 1.00 1.00 0<C1UD<w17 165 376 0.79 ( 0.59- 1.06) 0.84 ( 0.62- 1,13) 0.75 ( 0.54- 1.05) 0.82 { 0.61• i.tt) 0.77 ( 0.56- 1.05) 17<C1UD 55 230 0.79 ( 0.53• 1.19) 0.87 ( 0.57- 9.31) 0.78 ( 0.45- 1.33) 0.83 ( 0.55• 1.25) 0.82 ( 0.48• 1.38) £XCluded/Trsnd 6 18 0.12 0.11 0.08 0.12 ~ 0.12 HOSPITAL BASED STUDIES Non oxposod 93 0<C1UD<17 60 17<C1UD 90 Excludldl rrlnd 11 3 WITHOUT OCCASIONAL SMOKERS Non exposao ~ 181 D<C1UD<17 189 17<011.10 ~ 110 fxcluded/Trendl 61 AGE <55 YEARS Non oxposoa 67 0<C1UD<17 59 17<C1UD 381 .xcluded/rrendl ' AGE 55•64 YEARS Non expoaotl 0<C1U0<17 17<C1UD Ercludtd/Trend AGE 65+ YEARS Non exposetl 0<C1UD<17 17<C1UD 76 85 45 r"xcluded/Trendl 41 HISTOLOGICALLY CONFIRMED DIAGNOSIS oxposoo 242 Non O<C1UDe.17 230 17<C1UD 146 129 104 212 OR(11 95X Cl B OR(21 95% Ct ( OR(3) 95R C7 ( OR(4) 95^6 CI 1.00 1,00 F 1.00 - 1.00 0.98 ( 0.62- 1.56) 1.07 ( 0.65- 1.77) 0.77 ( 0.42- 1.42) 1.01 ( 0.63• 1.62) 0.50 ( 0.27- 0.94) 0.66 ( 0.33- 1.31) 0.62 ( 0.26- 1.50)! 0.51 ( 0.08 0,85 ( 0.55• 1.30) 1.00 0.62 ( 0.42- 0.92) 71 0.02 1.00 0,95 ( 0.57- 1.58) 0.61 ( 0.39- 0.96) ~ 0.02 € 0.10 C 0.08 1,00 1.07 ( 0.56- 2.05) 0.75 ( 0.43- 1.31) 0.02 364 1.00 1.00 t 1.00 390' 0.91 ( 0.69- 1.20) 0.97 ( 0.72• 1,29)i 0.91 ( 0.66• 1.25) 333If 0.87 ( 0.63• 1.20) 0.88 ( 0.62- 1.26)t' 0.88 ( 0.59- 1.33) 171 0.36 0.36 '14 1,00 128 0.73 ( 0.45- 1.18) 115I 0.64 ( 0.37- 1.11) 4 0.08 0.34 1.00 1.00 0.91 ( 0.54- 1.55) 1.09 ( 0.58- 2.06) 0.87 ( 0-47- 1.61)~ 1.01 ( 0.45- 2.26) 0.08 0.09 1.00 t 1.00 0.78 ( 0.50- 1.21)~ 0.85 ( 0.51- 1.44) 0.61 ( 0.41- 0.91) 0.58 ( 0.36- 0.92) 0.01 1.00 0.94 ( 0.71- 1.24) 0•88 ( 0.63• 1.23) 0.36 1.00 0.69 ( 0.42- 1.13) 0.65 ( 0.37- 1.14) 0.02 1•00 0.87 ( 0.64- 1.17) 0.81 ( 0.54- 1•22) 0.41 1•00 0,79 ( 0.45- 11.36) 0.49 ( 0.25- 0.96) 0.06 176 1.00 1.00 1.00 4 1.00 209 0.83 ( 0.55- 1.25) 0.81 ( 0.53- 1.25)~ 0.73 ( 0.45- 1.18)I 0,78 ( 0.52- 1.19) 154 0.78 ( 0.48- 1.27)! 0.72 ( 0.43- 1.22)I 0.82 ( 0.44- 1.53)I 0.77 ( 0.47- 1.26) 131 0.27 ~ 0.29 ~ 0.19 206 1.00 1.00 199 0.85 ( 0,59• 1.24) 0.86 ( 0.58- 1.26) 216 0.74 ( O.w9- 1.10) 0.76 ( 0.50- 1.16) 0.28 1•00 1.00 0•77 ( 0.49- 1.20)~ 0.91 l, 0.63• 1.33) 0.67 ( 0.40- 1.12) 0.75 ( 0.50- 1.12) j 0.18 0.11 0•08 1.00 ' 0.73 ( 0•46- 1.17)i 0•62 ( 0.34- 1.15) 0.29 1.00 0.82 ( 0.55- 1.23) 0.85 ( 0.54- 1.35) 0.74 496 1.00 1.00 1.00 1.00 1.00 536 0.82 ( 0.65• 1.04) 0.88 ( 0.68• 1.13) 0.82 ( 0.62- 1.09) 0.82 ( 0.65- S.OS) 0.80 ( 0.61- 1.04) 485 0.71 ( 0.54• 0.93) 0.75 ( 0.56• 1.01) 0.73 ( 0.52. 1.04) 0.72 ( 0.54- 0.94) 0.67 ( 0.48- 0.92) EXCIOded/Trend 9 25 0.01 ~ 0.01 t 0.01 0.01 0.01 t SCUAMOUS CELL CARCINOM A Non a%posetl 52 49s 1,0o 1.00 1.00 1•00 1-00 0<C1U0<17 34 536 1 0,54 (, 0.33• 0,88)1 0.58 ( 0.35• 0.97) 0.58 ( 0.33- 1,02) 0.54 ( 0,34- 0•88)1 0.54 ( 0.32- 0.92) 17<C1UD 22 485 0.50 ( 0.28- 0.89) 0.43 ( 0.22• 0.84) 0.60 ( 0.28- 1.27) 0.46 ( 0.26- 0.83) 0.40 ( 0.19- 0.85) f 2XC1(Ided/rrlnd! 5 2 I 0.00 I 0.00 ~ 0.00 0.00 ~ I1 0.01 SMALL CELL CARCINOMA Non exposao 25 496 1.00 1.00 1.00 1.00 - 1.00 0<C1U0<17 31 536 0.75 ( 0,4"- 5.32) 0.76 ( 0.42- 1 .36) 0.63 ( 0.35- 1.15) 0.79 ( 0.44• 1.40) 0.64 ( 0.36• 1,14) 17<C1UD 10( 485 0.70 ( 0.3i- 1.61) 0.71 ( 0.31- 1.66) 0.59 ( 0.23- 1•52) 0.78 ( 0.34- 1.83) 0.59 ( 0.24- 1.46) BXCIOded/Trtnd 1~ 251 0.27 ~ 0,26 0.25 0.33 0.28 ADENOCARCINOMA Non exposetl 124 496 1.00 1.00 1.00 1.00 ( 1.00 0<C11.10<217 125 536 0.88 (- 0.65• 1.19) 0.96 ( 0.69• 1.32)f 0.92 ( 0.64• 1.34) 0.88 ( 0.65- 1.20) 0.85 ( 0.61- 1,19) i7<C1U0 79 485 0.70 ( 0.49• 0.99) 0.77 ( 0.53• ` 1.13)] 0.76 ( 0.48- 1.22) 0.70 ( 0.49- ~ 1.00) 0.67 ( 0.44- 1,00) SXCluded/Trand 6~ 25 1 0.05 0.05 k t 0.06 ~ 0.03 0.05 OTHER Non exposad 38 496 t.0o t.oo 1. 00 1.00 1. 00 0<C1U0<17 40 536 0.98 ( 0,60• 1.59) 1.06 ( 0,63- 1.79) 1.03 ( 0.58- 1.84) 0.96 ( 0.59- 1.56) 1.18 { 0.68. 2.06) 17<C1UD 35 485 0.92 ( 0.55• 5.55) 1.07 ( 0.61- 1.89) 0.92 ( 0.47- 1.78} 0.97 ( 0.57- 1.63) 1.10 ( 0.59- 2 04) fxeluded/Trtnd ~ I 2 ~ II 25 I ~ 0.78 0.76 ~ 0.74 0.81 0.78 ~ 9755G OF LIFESPAN IN RURAL AREA OR INTERMEDIATE CITIES Non exposed 113 189 1.00 0<C1U0<17 ~ 100 231 0.67 ( 0.47• 0,97) 17<C1UD 39 150 0.56 ( 0.35• 0.92) 1,00 ( 1.00 1.00 1.00 0.67 ( 0.47• 0.97)i 0.62 ( 0.41- 0.94) 0.68 ( 0.47- 0.98) 0.66 ( 0•45- 0.96) 0.56 ( 0.35- 0.92) 0.54 ( 0.29- 1.01) 0.56 ( 0.34- 0.93) 0.58 ( 0.34- 1.00) Exc1udad/Trendl 4 ( S 0.01 0.01 0.01 ~ 0.00 0.01 ~-75'ti OF LIFESPAN IN URBAN AREA axposad 70 215 Non 0<C1U0<17 98~ 215 17<C1UD 72 266 1,00 ° 1.00 1.00 , 1.00 1.00 1.32 ( 0,88- 1,97) 1.32 ( 0.88- 1.97) 1.26 ( 0.79- 2.00) 1.28 ( 0.85- 1.93) 1.29 ( 0.82- 2.03) 1.01 ( 0.66- 1.55) 1.01 ( 0.66• 1.55) 1.05 ( 0.63- 1.73) 1.03 ( 0.67- 1.59) 0.93 ( 0.56- 1.56) ExCluded/Trenj 4~ 15 0.84 t 0.84 I 0.85 0.93 0•86 ~ (1) Model include sex, contar, acx•canter and age (2) Model xtcfuda sex, center, sex'canter, age and proportion of residential type in the tast 35 yrs (REUP) (3) Mode( include sox, center, sex'cente[, age, proportion of residential type in the last 35 yrs (REUP) and educational level (EDUC) (4) Model Fnc}uda sax, oanter, sox'center, ase and duration of exposure to list A agents (OCLAY) (5) Modal klcsude sex, centor, sex'center, age and frequency consumptton of vegetables (VEGE) 0 S Risk estimates - Childhood 0-18 years --

C1 US Childhood 0-18 yrs, Smoking parent years H1S70LOGICALLY CONFIRMED D{AGNOSIS Total Ezooscd UneyRosed~ Excluded Min I P10 1 01 Median 1 03 P90 ~ Max Mean Std 4 Men G®aC3 152 74 771 1 0.50 6.50 11.00 14.50 19.00 25.00 42.00 15.14 7.65 COntt0ls 580 335 236 9 1.00 6.50 11.00 19.00~ 19.00 35.00 65.50 18.04 10.69 AII 732 409 313 10 0.50 6.50 11.00 18.00f 19.00 33.00 65.50 17.52 10.26 Women Cases 531 333 190 8 0.50 6.50 11.00 18.50 19.00 28.50 68.00 17.49 10.111 Controls 1076 716 344 16 1.00~ 6.50 11.00 18.50 19.00 31.00 60.00 17.75 9.451 All 1607 1049 534 24 0.50! 6.50 11.00 18.50 19.00 30.50 68.00 17.67_ 9.66 A1! CaSCS 883 407 267_ 9 0.50 6.50 11.00 17.50 19.00 27.50 68.00 17.06 3.75 Controls 1656 1051 580 25 1.00 6.50 11.00 18.50 19.00 32.50 65.50 17.85 9.86 All 2339 1458 847 34 0.50 6.50 /1.00 18.50 19.00 31.00 68.00 17.63 9.83 SQUAMOUS CELL CARCINOMA MCn CBSCS 28 4 24 0 7.50 ! 7.50 9.25 11.00 15.00 19.00 19.00 12.13 4.87 Controls 580 335 236 9 1.00 6.50 11.00 19.00 19.00 35.00 65.50 18.04 10.69 AI 606 339 260 9 1.00 ~ 6.50 11.00. 18.50 19.00 35.00 65.50~ 17.97 10.65 . WOinGn ses Ci 97 39 37 '1 4.50 8.50 11.001 18.50 21.50 38.00 68.00 20.68 13.72 ConlrOls 1076. 716 344 16 1.00 6.50 11.00 18.50 19.00 31.00 60.00 17.75 9.45 All 1173 775 381 ' 1.00 6.50 11.00` 18.50 19.00 31.00 68.00 17.98 9.86 A11 C9sCs 125 83 61 1 4.50 8.50 11.00 18.50 21.00 28.50 68.00 20.13 13.48 Controls 1656 1051 580 25 1.00 6.50 11.00 18.50 19.00 32.50 65.50 17.85 9.86 All 1781 1774 641 26 1.00 6.50 11.00 18.50 19.00 32.50 68.00 17.97 10.10 MCn CoSCS Controls A8 14 5a0 594 7 335 342 236 243 0 9 9 3.00 4.00 1.00 3.00 6.50 6.50 10.50 11.00 11.00 1.00 1.00 19.00! 19.00 18.501 19.00 18.50 35.00 35.00 18.50 10.86 65.501 18.04 65.50 17.90 4.48 10.69 10.64 Wo(ttINt CiS05 67 42 24 1 1.50 7.50 11.00i 17.50 19.00 27.50 38.00 16.49 8.65 Controls 1076 716{ ~ 344 16 1.00 6.50 11.00 I 18.50 19.00 31.00 60.00 17.75 9.45 All 1143 758 368 17 1.00 6.50 11.00 18.50 19.00i 31.00 60.00 17.68 9.41 All Cases 81 49 31 1 i.50 7.50 11.00 15.50 19.00 27.50 38.00 15.68 8.39 Controls 1856 1051 580 25 1.00 6.50 11.00 18.50 ?9.00 32.50 i 65.50 17.85 9.86 Atl 1737 1100 611 26 1.00 6.50 11.00 18.50~ 19.00 32.50 65.SD 17.75 9.80 ADENOCARCINOMA Men Cascs 80 44 35 0.50 6.50 11.00 14.50 19.00 22.00 36.00 14.70 6.93 Controls 580 335 236 9 1.00 6.50 `;1.00 I 19.00~ 19.00 35.00 65.50 18.04 10.69 All 660 379 271 ?0I 0.50 ~ 6.50 11.00 18.50 19.00 34.50 65.50 17.66 10.37 WOmCf1 CBSCa 281 176 101 4 0.50 5.50 11.00 18.50 19.00 31.50 57.00 17.03 9.70 CCtttlCis 1076 716 344 16 1.00 6.50'! 11.00 18.50 19.00 31.00 60.00 17.75 9.45 All 1357 892 445 20 0.50 6.501 11.00 18.50 19.00 31.00 60.00 17,61 9,50 A!! CasCS 361 220 136 5 0.50 6.00 11.00 17.25 19.00 28.75 57.00 16.56 9.25 Controls 1658 1051 580 25 i.00~ 6.50 11.00 18.50 19.00I 32.50 65.50 17.85 9.86 All 2017 7271 716 30 0.50 6.50 ?1.00 18.501 19.00 32.00 65.50 17.82 9.76~ MCn CdSCb 30 19 `,1 0 1.50 2.50 11.00 18.50 25.00 31.00 42.00 18.34 9.58 Controls 1 580 335 236 9 1.00~ 6.50 11.001 19.00 19.00 35.00 65.50 18.04 10.69 A11 610 354 247 9 1.001 6.50 11.00 18.50 19.00 35.00 65.50 18.06 10.62 Women Cases a6 ss za 2 ® 1.00 7.50 ?t.oo 'a.oo 19.00 21.00 38.00 16.32 7.041 Controls 1076 716 344 ?6i 1.00 6.50 11.00 18.50 19.00 31.00 60.00 17.75 9.451 All !182 772 372 18i 1.00 6.50 11.00 18.50 19.00 30.00 60.00 17.65 9.30 All Cases '16 75 39 2 1.00 7.50 11.00 18.50 19.00 25.50 42.00 16.83 7.74 Controls 1856 1051 580 25~ 1.00 5.50 11.00 18.50! 19.00 32.50 65.50 17.85 9.86 All ~ 1772 1126 619 27 1.00 6.501 11.00 18.501 19.001 32.00 65.50 17.78 9.73 >75'' OF UFESPAN IN RURAL AREA OR INTERMEDIATE CITtES Men Cases 76 30 45 1 0.50 8.00 11.00 11.00 18.00 19.00 36.00 13.57 6.43 Conlfol6 225 120 103 2 1.00 5.50 11.00 16.25 19.00 35.00 45.00 17.10 10_05 AI1 301 150~ 148 3 0.50 5.50 11.00 15.00 19.00 34.75 45.00 16.39 9.53 Wofnen Cases ° 237 140 94 3 1.50 a.75 11.00 17.50 19.00 34.50 68.00 17.90 9.90 Controls 462 290 169 3 1.00 6.50 11.00 17.50 19.00 29.50 51.00 16.79( 8.641 All 699 430 263 6~ 1.00 7.25 11.00 17.50 19.00 29.50 68.00 17.15 9.07j All C35es 313 1:70 139 4! 0.50 c.50 11.00 16.75 19.00 31.00 68.00 17.13 9.51 Controls 687! 410 272 , 5 1.001 6.25 11.00 17.50 19.00 33.001 51.00 96.88 9.06 All 10001 580 411 9 0.50 6.501 11.00 17.50 19.00 33.00 68.00 16.96 9.19 >75% OF LIFESPAN IN URBAN AREA MCtt C85C5 45 33 15 0 2.50 6.50 11.00 17.50 19.50 26.50 42.00 17.02 8.61 ~ Conirols 257 155 961 6 1.00 6.00 11.50 19.00 19.00 36.00 65.50 18.88 11.791 All 305 18a1 111i 6 1.00 6.00 11.00 19.00 19.00 31.00 65.50 18.55 11.30 Women CasC3 196 137 55 4 0.50 5.00 11.00 18.50 19.00 26.00 62.00 16.18 9.22 ; { Controls ~ 454 326 119 9 1.00 6.50 11.50 19.00 19.00 34.00 60.00 19.25 10.161 All 650 463 174 13 0.501 7.50 11.00~ 19.00 19.00 31.50 62.00 18.34 9.98 All CBsCs 244! 170 70 4 0.50 5.25 91.00 18.50 19.00 26.50 62.00 16.34~ 9.08 Controls All 711 955 481 651l 215 285 15I 1.00I 8.50 19 0.50i 7.50 11.50 11.00 11 19.00 19.00 19.00 19.00 34.00 31.00 65.50 65.50 19.13 18.40 10.70 10.37 `Jb3593344 Descriptive statistics - Childhood 0-18 years

Spouse, ever exposed dr+al ot.xpcs~:c Gsez CoMxolz OR(11 95% CI ) OR 2 95% CI OR 3 95% Ct € OR 4 95% CI ( OR(5) 95% CI Non exposed 118 462 1.0o 1 .00 1 1.00 1.00 1.00 Exposed 23 68 1.47 ( 0.81- 2.66) 1.55 ( 0.82- 2.94)~ 1.08 ( 0.46- 2.56) 1.46 {0.80- 2.65) 1.51 ( 0.78- 2.94) I dxCludtd/Trand 0 ? ~ 1.00 1.00 1.00 1.00 1.09 ( 0.85- 1.40)~ 1.07 ( 0.80- 1.42)~ 1.12 ( 0.89- 1.42)~ 1.06 ( 0.81- 1.38) Excludtd/Tivndi POPULATION BASED STUDIES Non exposed tes 577 1.00 1. 00 1.00 1.00 1.00 g EXpOSed 191 372 1.09 ( 0.82• 1.44) 1.11 ( 0.83- ;.49) 1.10 ( 0.78- 1.55) 1.11 ( 0.83- 1.49)~ 1.17 ( 0.85- 1.61)~ E,rcludid/Trtnd ~ f HOSPITAL BASED STUDIES Non oxpoaod 111 201 1.00 1.00 1.00 1.00 1.00 Exposed 135 248 1.20 ( 0.83- 1.72) 1.07 { 0.70- 1.64) 0.97 ( 0.59- 1.62) 1.20 ( 0.83- 1.74) 0.95 ( 0.62- 1.45)~ EXCludtd/Trtnd 0 , 3 ~ t ~ ~ Non exposed 225 59 3 1.00 ~ 1.00 , 1.00 1.00 1.00 Exposed 260 509 1.17 (, 0.91- 1.50) 1.14 ( 0.87- 1.50)I 1.01 ( 0.75- 1.37) 1€ 1.18 ( 0.92- 1.53) 1.09 ( 0.81- 1.46) Excludtd/Trtnd i 2 11 i ~ Non Q%pOtetl 84 215 1.00 ~ 1.00 1.00 1.00 1.00 I€ EXp08ed 70 145 0.99 ( 0.64• 1.52) 1.03 ( 0.64• 1.66)~ 1.11 ( 0.63- 1.95) 0.98 ( 0.63- 1.52) 1.06 ( 0.65- 5.73)' Exc1udsd/Trond AGE 55-&4 YEARS expOSQtl Non EXpesed 98 309 1.00 1.00 1.00 1.00 1.00 ?12 241 1.19 ( 0.80- 1.76) 1.03 ( 0.68- 1.57) 0.82 { 0.51- 1.30) 1.18 ( 0.79- ?.76)~ 1.06 f, 0.67- 1.68) Excludid/Trond 0 2 AG€ 6S+ YEARS Non exposed Exposed 113 314 1.00 t.00 1.00 1.00 1.00 162 314 1.25 ( 0.89- 1.75) 1.33 ( 0.93- ?.89) 1.36 ( 0.89- 2.09) 1.30 ( 0.92• 1.82) 1.25 ( 0.86- 1.82) cxcludtd/Trond~ 0 + , ~ HISTOLOGICALLY CONFIRMED DIAGNOSIS Non exposed 296 838 1.00 1.00 ' t.oo 1.00 1.00 Exposed 330 700 1.12 ( 0.90. 1.40) t.12 ( 0.89- 1.42)i 1.10 ( 0.84• 1.44) 1.14 ( 0.91- 1.42) 1.12 ( 0.88- 1.44) Excl udtd/Trtnd I 4 ~ SQUAMOUS CELL CARCINOM A Non Q%poaetl t 50 838 1.00 1.00 1.00 1.00 Exposed ~ 59 700 1.21 ( 0.77- 1,91) 1.03 ( 0.63- 1.69) 1.00 ( 0.58- 1.74) 1.17 ( 0.74- 1.86) 0.98 ( 0.58- 1.65) gxcluded/Trtndt 0 4 SMALL CELL CARCINOMA Non Q Xp01ed 31 838 1.00 1.00 1.00 1.00 1.00 ed EXpos 39 7001 1.39 ( 0.79- 2.45) 1.35 ( 0.75• 2.43)1 1.42 ( 0.75- 2.68) 1.39 ( 0.78• 2.47) 1.36 { 0.75- 2.45) :xciudtd/rrend 01 41 ~ , ADENOCARCINOMA Non exposetl~ 159 838 1.00 1.00 1.00 1.00 E 1.00 Exposed 174 700 1.08 ( 0.82- 1.42) 1.10 ( 0.82- 1.48) 1.07 { 0.76- 1.52) 1.12 ( 0.84- 1.48)i 1.08 ( 0.80- 1.48) OTHER fxcludad/Trtnd ~ 01 4 Non expose0 56 838 1.00 1.00 1.00 1.00 ~ 1.00 Exposed ~ 58~ 700 1.05 ( 0.68- 1.63) 1.15 ( 0.72. 1.84) 1.06 ( 0.62- 1.81) 1.08 ( 0.69- 1.68){! 1.22 ( 0.74- 2.00)~ Excludtd/Trand 41 >75% OF LIFESPAN IN RURAL AREA OR INTERMEDIATE CITIES Non exposed € 122 321 1.00 Exposed I{ 134 253 1.23 ( 0.86. 1.00 f 1.00 1.00 1.00 5.77) 1.23 ( 0.86- t.77)I 1.01 ( 0.67- 1.54) II€ 1.22 ( 0.85- 1.76) 1.08 ( 0.74- 1.57) Excludtd/Trend~ 0 °1 1 ~ F >759G OF LIFESPAN IN URBAN AREA Non Qxposed 103 356 1.00 1.00 1.00 j 1.00 1.00 Exposed II[ 141 353 1.05 { 0.74- 1.49)f ( 1.05 ( 0.74- 1.49) 1.14 ( 0.76- 1.71) 1.05 ( 0.74- 1.501 1.18 ( 0.79- 1.7 1 7) ExcludedJrrendl 0 1 2 ~ (1) Model Include sEx, center, sex'center and age (2) Model tnduda sex, center, sex'center, age and proportion of residentlar type in the rast 35 yrs (REUP) (3) Model Indude sex, center, sex'center, age, proportion of residential type in the last 35 yrs (REUP) and educational level (EDUC) (4) Model indude sex, center, sex•center, aDe and duration of exposure to list A agents (OCLSY) (5) Model Include sex, center. sex'cen(er, age and frequency consumption of vegetables (VEGE) Risk estimates - Spouse

®_OSCU Occasional smoking, Cumulative exposure (packs/lifetime) MEN ONLY Lwal ot exuosure OSCU<5 NE., S<C$OU<r12 12<OSCU ° Cascs Contsnls ORI1 95% CI ) OR 95% CI f OR 3 95% CI ( OR 4) 95% CI ( OR(5) 95% CI ( 122 449 1.00 1.00 1.00 1.00 1.00 ~ 9 25 0.95 { 0.39- 2.35) 0.84 ( 0.28- 2.48) 0.35 ( 0.04- 3.00) 0.80 ( 0.31• 2.04) 0.98 ( 0.34- 2.88) 3 19 0.42 { 0.11- 1.61) 0.63 ( 0.16- 2.44) 0.56 ( 0.10- 3.25) 0.53 ( 0•14- 2.03) ~ 0.71 ( 0.17- 3.04) Fxcluded/Trend 7 38 0.26 0 0.27 0.30 0.28 0.25 WOMEN ONLY NE., OSCU<5 454 5<0SCU<12 8 12<OSCU ~ 9 920 1.00 1•00 1.00 l.oo ) 1.00 27 0.56 ( 0.25- i.26)IE 0.64 { 0.28- 1.45) 1.06 ( 0.44- 2.60) 0.60 ( 0.26- 1.37) 0.72 ( 0.31- 1•68)1 14 1.41 ( 0.58- 3.40)' 1.31 ( 0.50• 3.45) 1.53 ( 0.41- 5.69) 1.44 ( 0.60- 3.47] 1.03 ( 0.32- 3.28) Excluded/Trend 38 ~ 150 0.92 I€(I 0.85 0.83 ~ 0.93 0.91 € POPULA11ON BASED STUDIES NE., OSCU<s5 366 880 1.00 1.00 1.00 1.00 00 1 . 5<OSCU<12 6 32 0.48 ( 0.19- 1.21) 0.51 ( 0.20- 1.30) 0.72 ( 0.23- 2.27) 0.41 ( 0.15• 1.10) 0•62 ( 0.23- 1.63) 12<OSCU S 20 0.96 ( 0.33- 2.78) 1.04 ( 0.36- 3.02) 1.10 ( 0.28- 4.30) 0.99 ( 0.34- 2.84) 0.94 ( 0.22- 4.05) E.rc1 udcd/Trend f 18 0.36 0.37 0.42 0.39 ~ 0.36 HOSPITAL BASED STUDIES NE,, OSCU<.5 5<OSCU<12 12<OSCU 210 389 1.00 1.00 ?.00 1•00 1.00 11 20 0.95 ( 0.42- 2.14) 0.97 ( 0.38- 2.46) 0.92 ( 0.30- 2.84) 1.03 { 0.45• 2.34) 1.01 ( 0.41• 2.51) ) 7 13 0.96 ( 0.36- 2.59) ' 1.10 ( 0.35- 3.46) 1.20 ( 0.24- 5.98) 1.17 ( 0.43- 3.18) 0.86 ( 0.27- 2.72) FYCluded/Trandl 18 s. 3of 0.90 0.87 0.84 0.92 0.81 WITHOUT OCCASIONAL SMOKERS Excluded/Trend! 486 AGE <55 YEARS NE., 0SCU<5 5<0SCU<.12 12<OSCU 147 315 1.00 1.00 1.00 1.00 1.00 8 19 0.94 ( 0.37• 2.38) ~ 0.77 ( 0.26• 2.27) 0.52 (, 0.10- 2.59) 0.77 ( 0.29- 2.03)i 0.84 ( 0.30- 2.35) € 4 14 0.71 { 0.21- 2.43) 1.19 { 0.33. 4.35) 1.18 ( 0.25- 5.69)~ 0.87 ( 0.25- 3.04)! 0.76 ( 0.18• 3.30)1 Fxcluded/Trendl 6 7 3 0.60 j 0.59 0.59 ~ 0.59 ~ 0.59 i AGE 55-64 YEARS NE., OSCU<5 187 463 1.00 1.00 1.00 1.00 1.00 5<0SCU<12 4 15 0.57 { 0,17- 1.90) 0.49 ( 0.13- 1.83) 1.07 { 0.25- 4.65) 0.62 ( 0.19- 2.08) 0.53 ( 0.14- 2.07)1 12<OSCU 3 2 0.72 ( 0.17- 3.06) 0.28 ( 0.03- 2.44) 0.00 ( 0.00-99.99) 0.74 ( 0.17- 3.15) 0.51 ( 0.05- 5.00)1 Exciuded/Trend~ AGE 65+ YEARS 16 66 0.40 ~ 0.47 j 0.45 ~ 0.42 0.40 NE., OSCU<5 ! 242 491 1,00 1.00 1.00 1.00 1.00 6<OSCU<12 i 5 18 0.67 (- 0.23- 1.96) 0.87 ( 0.29- 2.60) 1.14 ( 0.32• 3.99) 0.71 ( 0.24- 2.11) 0.91 ( 0.28- 2.93) El 12<OSCU 5 11 1.40 ( 0.43- 4.52) 1.68 ( 0.51- 5.55) 3.15 ( 0.62-16.11) 1.43 ( 0.44- a.63) 1.23 ( 0.31- 4.93) ExCludadiTrendl 23~ 109 0.91 0.88 0.93 ~ 0.90 0.98 HISTOLOGICALLY CONFIRMED DIAGNOSIS NE., OSCU<5 560 5<0SCU<12 181 12<OSCU 12 ~ EXcltJded/Trend .39! SCUAMOUS CELL CARCINOMA NE., 0SCU<6 5<OSCU<12 12<0SCU Excluded/Trend SMALL CELL CARCINOMA NE,a 05C1.1<5 5<0SCUu12 12<OSCU Excl uded/Trend ADENOCARCtNOMA NE., 0SCU<5 5<0SCU<12 12<OSCU 4 4 3 8 58 8 1269 52 33 1.00 ~ 1.00 0.67 ( 0.36• 1.22)~ 0.64 ( 0.33- 1.25) 0.94 ( 0.46• 1.94)( 1.06 ( 0.49- 2.31) t 1.00 0.82 ( 0.37- 1.82) 1.13 ( 0.40- 3.14) 0.44 1.00 0.64 ( 0.34- 1.20) 1.06 ( 0.51- 2.18) 1.00 0.80 0.88 - i 0.44 ~ 0.39 1881 0.42 ~ 0.41 1269 52 33 188 1269 52 33 188 1.00 j 1.00 1.00 1.00 .00 1•27 (, 0.42- 3.87) 1.42 ( 0.41- 4.92) 2.22 ( 0.59- 8.38)1 1.29 f, 0.42- 4.01)i 1.69 1.78 ( 0.48• 6.57)~ 2.50 ( 0.67- 9.33) 6.23 ( 1.30-29.86) 2.22 ( 0.61- 8.08)I 2.04 0.35 ~ 0.35 f 0.36 € 0.36 ~ 0.37 1•00 -j 1.00 1.00 1.00 1.00 3.27 ( 1.01•10.63)1 3.30 ( 1.00-10.93) 4.16 ( 1.14-15.17) 2.21 ( 0.58- 8.34) 3.73 0.00 ( 0.00-99.99)' 0.00 ( 0.00-99.99) 0.00 ( 0.00-99.99)' 0.00 ( 0.00-99.99) 0.00 0.45 ( 0.41 E i 0.42 1 0.43 ~ 0.41 ~ ( 0.41- 1.54) ( 0.36- 2.16)i I ( 0.48• 6.00) ( 0.40•10.45) ( 1.10-12.68) ( 0.00-99.99) f 302 1269 1.00 1.00 1.00 1.00 1.00 III 6 52 0.42 ( 0.17- 1.02) 0.25 ( 0.07- 0.84)I 0.32 ( 0.07- i.38) 0.44 { 0.18- 1.09) 0.45 ( 0.17- 1.19) ~ 9 33 1.28 ( 0.57- 2.88) 1.38 ( 0.56• 3.42) l 1.00 { 0.26- 3.83) 1.48 ( 0.65- 3.33) 1.15 ( 0.42- 3.14) Ex cludad/Trendi >6 188 0.64 J i 0.60 ~ 0.62 ! 0.67 t 0.60 OTHER NE., 05CU<.5 1 106 5<0S0U<12 f 2 12<0SCU 1 0 Excluded/Trendll 7 1 1269 52 33 188 1.00 0,36 ( 0.00 ( 0.04 0.08- 1.54)i 0.00-99.99) 1.00 0.44 ( 0.00 ( 0.04 I 0.10- 1.94)) 0.00-99.99)!I ~ 1.00 t 1.00 0.00 ( 0.00-99.99)~ 0.37 ( 0.00 ( 0.00-99.99) 0.00 ( E 0.05 ~ 0.04 0.09- 1.62) 0.00-99.99) 1.00 0.48 ( 0.00 ( 0.04 0.11- 2.?1)j 0.00•99.99)' >755G OF LIFESPAN IN RURAL AREA OR INTERMED IATE CITIES NE, OSCU<5 E 221 422 1.00 1.00 ~ 1.00 1.00 1.00 5<0SCU<12 7 20 0.80 ( 0.31- 2.01) 0.80 1 0.31- 2.01) 0.71 ( 0.23- 2 13) 0.60 ( 0.22- 1.62) 0.69 ( 0.26- 1.83) ~ 12<OSCU 3 10 0.62 ( 0.16- 2.42) 0.62 ( ~ 0.16- 2.42) 0.97 ( 0.15- 6.24) 0.61 { 0.16• 2.39) 0.63 ( 0.15- 2.57) Excluded/Trendl 251 123 0.41 0.41 i ! 0.39 0.34 I 0.35 :.7554 OF LtFESPAN IN URBAN AREA USCU<.5 NE., 223 627 7.00 1.00 1.00 1.00 1.00 5<0SCU<.12 3 23 0,69 ( 0.24- 1.99 ) 0.69 (, 0.24• 1.99)1 0.74 ( 0.19- 2.85) 0.78 ( 0.27- 2.31) 1.23 ( 0.38• 3.96) 12<OSCU 5 14 1.64 t 0•53• 5.06) 1.64 ( 0.53- 5.06)I 1.01 ( 0.19- 5.42) 1.74 ( 0.56• 5.42)~ 3.46 ( 0.67-17.84) FXCluded/Tlend '1~ 47 0.71 0.71 ~ 0.70 ~ 0.63 ~ 0.73 (1) Model include sex, center, sex'center and age (2) Model uxlude sex, center, sex'center, age and proportion of residential type in the last 35 yrs (REUP) (3) Model Include sex, center, sex'center. age, proportion of res,dential type in the last 35 yrs (REUP) and educational level (EDUC) (4 j Madd fnUude sex, canfe , sex'center, ege and durauon of exposure to list A agencs (OCLAY) (5) Model include sex, center, sex'center, age and frequency consumption of vegetables (VEGE) Risk estimates - Occasional smoking

2.3.6 Spouse and workplace Risk estimates

Childhood 0-18 yrs, Smoking parent years MEN ONLY Gval of exposuro Casas Controls Notl axpaald 65 201 0<C1US<^18 51 164 19<01US4631 21 120 31<C1US 3 37 ~XCludsd/rrsnd 9 OR(1) 96% CI OR12 95% Cl 0R13 95X Cl 0 4 95% Cl ORIS 95% d 1.00 7.00 1.00 1.00 1.00 1.04 ( 0.65- 1.67) 1.16 ( 0.70- 1.93) 0.85 ( 0.46- 1.57) 1.07 ( 0.66- 1.73) 0.95 ( 0.55- 1.62) 0.59 ( 0.31- 1.11) 0.69 ( 0.35- 1.38) 0.61 ( 0.26- 1.44) 0.58 ( 0.31- t.11) 0.47 ( 0.21- 1.03) 0.24 0.06- 0.88) 0.37 ( 0.10- 1.38) 0.19 ( 0.02- 1.66) 0.29 ( 0.08- f.05) 0.44 ( 0.11- 1.77) 0.02 0.02 0.02 0.02 0.02 WOMEN ONLY Non exposeo 187 295 1.00 1.00 E 1.00 7.00 1.00 0<C1US<^19 177 365 0.78 ( 0.59- 1.02) 0.81 ( 0.61- 1.08) 0.84 ( 0.61- 1.16) 0.76 ( 0.58- 1.01) 0.77 ( 0.57- 1.04) 19<C1US<^31 120 267 0.81 ( 0.60. 1.10) 0.84 ( 0.61- 1.17) 0.87 ( 0.59- 1.29) 0.83 ( 0.61- 1.13) 0.80 ( 0.56- 1.15) 31<C1US 17 1 68 0.59 ( 0.33- 1.07) 0.51 ( 0.26- 0.981 0.43 ( 0.20- 0.93) 0.57 0.31- 1.05) 0.52 ( 0.23- 1.20) Excl uded/Trond 0 16 0.04 0.04 0.03 0.03 0.04 POPULATION BASED STUDIES Non exposed 0<C1U8<^19 19<C1US<r31 31<C1US 152 326 1.00 1.00 1.0o 1.00 1.00 148 343 0.77 ( 0.57. 1.04) 0.81 ( 0.60- 1.10)1 0.71 ( 0.50- 1.00) 0.80 { 0.59- 1.08) 0.73 ( 0.53- 1.01) 60 201 0.88 ( 0.60. 1.30) 0.97 ( 0.65- 1.44)1 0.98 { 0.60- 1.60) 0.94 ( 0.63- 1.38) 0.89 ( 0.56- 1.44) 12 62 0.65 ( 0.32. 1.32) 0.73 ( 0.35- 1.49)1 0.57 ( 0.23- 1.41) 0.64 ( 0.31- 1.33) 1.22 ( 0.43- 3.45) excludid/Trsnd 6) 18 0.14 0.13 0.10 0.14 0.15 HOSPITAL BASED STUDIES Non exposad 0<01US<^19 19<C1US<r31 31<C1US Excluded/Trend FYiTHOUT OCCASIONAL SMOKERS 1.00 1.00 1.00 1.00 € 1.00 0.84 ( 0.54- 1.28) 0.94 ( 0.57- 1.56) 1.11 ( 0.59- 2.08) 0a7 ( 0.50- 1.19) 0.85 ( 0.51- 1.42) 0.67 ( 0.45- 1.00) 0.66 ( 0.42• 1.06) 0.78 0.44- 1.38)~ 0.65 ( 0.43• 0.98) 0.62 ( 0.38- 1.00) 0.35 ( 0.14• 0.86) 0.22 ( 0.06- 0.77) 0.25 ( 0.05- 1.21) 0.37 (-0.15- 0.92) 0.24 ( 0.07- 0.89) 0.01 0.01 ( 0.01 0.00 0.01 Non axposad 1111 364 1.00 1.00 1.00 1.00 1.00 0<01US<^19 179 386 0.89 ( 0.67- 1.17) 0.94 1 0.70- 1.26) 0.90 ( 0.65• 1.23) 0.91 ( 0.69- 1.20) 0.84 ( 0.82- 1.13) 19t01USb31 105 266 0.96 ( 0.69- 1.33) 1.00 ( 0.70- 5.44) 1.01 ( 0.68- 1.52) 1.00 { 0.72- 1.38) 0.92 ( 0.62- 1.37) 31<C1US 1S 71 0.66 f 0.35- 1.24) 0.65 ( 0.33- 1.27) 0.52 ( 0.23- 1.15) 0.65 ( 0.34- 1.25) 0.62 ( 0.25- 1.54) EzcltWed/Trsnd o 17 0.27 0.27 0.26 0.27 0.32 AGE<63YEARg Non oxposa 0<C1U$<r19 19<C1USh91 31<C1US EXC1U AGE 65-64 YEARS o 67 114 1.00 1.00 1.00 1.00 1.00 52 114 0.70 ( O.a3- 1.15) 0.89 ( 0.52- 1.53) 1.05 ( 0.55- 2.02) 0.66 ( 0.40- 1.09) 0.70 ( 0.40- 1.23) 38 98 0.73 ( 0.43• 1.26) 0.94 t 0.52- i.72) 1.25 ( 0.60• 2.60) 0.75 ( 0.44- 1.30) 0.60 ( 0.32- 1.13) 7 31 0.49 ( 0.18- 1.31) 0.75 ( 0.25- 2.23)1 0.33 ( 0.06- 1.90) 0.44 ( 0.15- 1.25) 0.69 ( 0.18- 2.70)1 ded/TI`end 1 4 0.09 0.09 0.09 € 0.06 0.09 Non axpos6a 7s n6 1.00 1.00 1.00 1.00 1.00 0<C1USe019 88( 210 0.90 ( 0,60- 1.35) 0.88 ( 0.58- 1.36) 0.81 ( 0.50- 1.32) 1 0.83 ( 0.55- 1.26) 0.78 ( 0.49- 1.24) 19<C1US<031 37 119 0.74 ( 0.44- 1.23) 0.69 ( 0.40- 1.18) 0.73 ( 0.38- 1.40)1 0.75 ( 0.45- 1.26) 0.59 ( 0.31- 1.13) 31tC1US 5~ 34 0.42 ( 0.15• 1.16) 0.34 .r, 0.11- 1.04j~ 0.30 ( 0.08- 1.08) 0.41 f 0.15- 1.16) 0.23 ( 0.05- 1.04) EXC10ded/Trend . 4 13 0.07 0.07 0.04 0.07 0.07 AGE 65+ YEARS Non exposetl 109 205 1.00 1.00 1.00 1.00 1.00 0<C1US<^19 88 205 0.82 ( 0.57- 1.19) 0.82 0.56- 1.21) 0.73 ( 0.47- 1.13) 0.88 1 0.61- 1.28) 0.80 ( 0.54- 1.20) 19<C1US<^31 68 170 0.82 ( 0.54• 1.24) 0.89 1 0.57- 1.38) 0.79 ( 0.46- 1.35) 0.83 ( 0.54- 1.26) 0.92 ( 0.57- 1.48) 31<C1US 8 40 0.53 ( 0.23• 1.26) 0.42 i 0.16- 1.09) 0.47 ( 0.16- 1.36) 0.55 ( 0.23- 1.31) 0.67 ( 0.23- 1.97) cxclUded/Trend 4 8 0.11 0.11 0.13 0.10 ) 0.13 H)STOLOGICALLY CONFIRMED DIAGNO SIS 442 Non exposed 496 1.00 1.00 1.00 1.00 1.00 2121 0<C1US<^19 529 0.82 ( 0.65• 1.04) 0.87 ( 0.68. 1.13) 0.83 ( 0.62- 1.10) 0.82 ( 0.64- 1.04)1 0.79 ( 0.61- 1.03) 10<C1US<^31 136 387 0.77 ( 0.59• 1.02) 0.83 ( 0.62. 1.11) 0.82 0.58• 1.17) 0.79 ( 0.60- 1.04) 0.73 ( 0.53• t.01)~ 31<C1US 191 105 0.47 0.27- 0.82) 0.47 ( 0.26- 0.85) 0.36 ( 0.17- 0.76) 0.48 ( 0.27- 0.84) 0.46 ( 0.22- 0.96) Excl ude d/Trend 9 E5 0.00 0.00 0.00 0.00 0.00 SQUAMOUS CELL CARCINOMA Non exposed 52 496 1.00 1.00 1.00 1.00 1.00 0<C1US<^19 33 529 0.53 ( 0.33• 0.87) 0.57 ( 0.35- 0.96)! 0.57 ( 0.32- 1.01) 0.52 ( 0.32- 0.84) 0.55 ( 0.32- 0.93) 10<C1US<^31 20 387 0.55 0.31• 0.99) 0.49 ( 0.25- 0.95)1 0.66 ( 0.31• 1.41) 0.56 ( 0.31- 1.00) 0.46 ( 0.22• 0.98) 31<CIUS 3 105 0.35 ( 0.10- 1.21) 0.31 ( 0.07- 1.34) 0.41 0.09- 1.88) 0.25 ( 0.06- 1.11) 0.00 ( 0.00-99.99) cXclUded/Trend 25 0.01 0.01 0.01 0.01 0.01 SMALL CELL CARCINOMA Non exposad 49c 1.00 1.00 1.00 1.00 1.00 0<C1US<^19 31 529 0.76 ( 0.43- 1.32) 0.76 ( 0.43- 1.36) 0.64 ( 0.35- 1.16) 0.79 ( 0.45• 1.41) 0.64 ( 0.36- 1.14) 10<C1U5<a31 9 3871 0.73 ( 0.31- 1.70) 0.75 ( 0.31- 1.80) 0.69 ( 0.27- 1.78) 0.79 ( 0.34- 1.87) 0.69 ( 0.28• 1.70) 31<C1US 105 0.48 0.06- 3.80) 0.47 ( 0.06• 3.76) 0.00 ( 0.00-99.99) 0.56 ( 0.07• 4.52) 0.00 ( 0.00-99.99) rxcludsd/Trend 25 1 0.25 0.23 0.23 0.30 0.26 ADENOCARCINOMA Non exposed 0<C1US<a19 19<C1US<^31 31<C1US 124 496 1.00 1.00 1.00 7.00 1.00 119 529 0.86 ( 0.64- 1.17) 0.93 0.67- 1.29) 0.92 ( 0.63• 5.34) 0.87 { 0.64- 1.18) 0.83 ( 0.59- 1.16) 74 387 0.77 ( 0.54• 1.09) 0.86 ( 0.59- 1.26) 0.84 ( 0.53- 1.33) 0.77 ( 0.54- 1.10) 0.71 ( 0.47- 1.07) 111 105 ~ 0.54 0.27- 1.07) 0.57 ( 0.27- 1.23) 0.52 ( .21• 1.31) 0 0.57 { 0.28- 1.15) 0.63 ( 0.27- 1.52) Excluded/Trend a`1 25 0.04 0.04 0.04 0.03 0.04 OTHER Non exposed 38 496 1.00 1.00 1.00 1.00 1.00 0<C1US<^19 38 ~ 529 0.97 ( 0.59- 1.59) 1.05 { 0.62- 1.78) 0.99 ( 0.55- 1.79) 0.95 { 0.56- 1.55) 1.11 ( 0.63- 1.95 ) 10<C1US<031 33 387 1.06 ( 0.63• 1.78) 1.25 ( 0.71- 2.19) 1.17 ( 0.61- 2.24) 1.09 ( 0.65- 1.84)1 1.26 0.68• 2.33)I 31<C1US 4 105 0.44 ( 0.17• 1.47) 0.45 ( 0.13- 1.58) 0.19 ( 0.02- 1.49) 1 0.53 ( 0.18• 1.58) 0.86 ( 0.24- 3.i3)f Exclude d/Trend 2 25 0.42 0.40 0.39 0.45 0.43 465i OF L1F£SPAN IN RURAL AREA OR INTERMEDIATE CITIES ( Non exposetl 113 189 1.00 1.00 1.00 1.00 1.00 0<C1US<^19 102 232 0.74 ( 1.06) 0.52- 0.74 ( 0.52- 1.06) 0.67 { 0.45- 1.01) 0.74 ( 0.51- 1.06) 0.73 ( 0.50- 1.06) 19<C1US<^31 35 115 0.52 ( .32• 0.86) 0.52 ( 0.32- 0.86) 0.51 ( 0.27- 0.97) 0.54 ( 0.32- 0.89) 0.51 ( 0.29- 0.90) 31<C1US 2 34~ 0.16 f .04- 0.70) 0.16 ( 0.04- 0.70) 0.00 ( 0.00-99.99) 0.16 ( 0.04- 0.72) 0.10 ( 0.01- 0.79) :xcluded/Trend 4i 5 0.00 0.00 0.00 0.00 0.00 >75lC OF LIFESPAN IN URBAN AREA Non exposed 70 215 1.00 1.00 1.00 7.00 1.00 <^19 0<C1US 92 210 1.29 ( 0.86- 1.94) 1.29 ( 0.86. 1.94) 7.24 ( 0.77- 1.97) 1.26 { 0.83- 1.91) 1.24 ( 0.78 - 19<C1US<^ 31 69 211 1.15 0.75- 1.76) 1.15 ( 0.75• 1.76) 1.18 ( 0.72• 1.96) 1.17 ( 0.76• 1.81) 1.08 ( 0.65- 1.81) ~ 31<C1US 9 60 0.63 0.28- 1.41) 0.63 ( 0.28• 1.41) 0.61 ( 0.23- 1.62)! 0.57 1 0.24- 1.33) 0.67 ( 0.22- 2.00) €xcluded/Trand 41 15 0.62 0.62 0.62 1 0.56 0.63 L (1) Model include sex, centor, sox'cantet and age (2) Modo) Include sex, canter, sox'conter, age and proportion of residential We in the tast 35 yrs (REUP) (3) Model ktcluda sax, center, sex'eanter, age, proportron of residential type in the last 35 yrs (REUP) and educational 4evel (EDUC) (4) Modal include sex, oenter, sox'canter, age and duration of exposure to list A agents (OCLAY) (5) Mo,Ya( tncfude sax, center, sox-center, aga and frequenc.y consumption of vegetadies (VEGE) R7 2063593320 Risk estimates - Childhood 0-18 years

clus Childhood 0-18 yrs, Smoking parent years ALLCENYERS Total Exoo-cd Unexoosed Exduded Min P10 01 Median 03 ~ P90 ~ Max j Mean ~ Std Ma1 Cases 141 75 65 1 0.50 6.50 11.00 14.50 1 19.00 25.00 42.00 15.15 7.60, Contt0lS 531 ~ 321 201 9 1.00 6.00 11.00 18.50_ i 19.00 33.50 ~ 65.50 17.79 10.60i All 672 396 266 10 0.50 6.00 11.00 17.50 19.00 31.00 65.50 17.29 10.141 Women Cases 808 314 187 8 0.50 6.50 11.00't 17.50 19.00 25.50 62.00 16.36 9.00 Controls 1011 700 295 16 1.00 6.50 11.001 18.50 19.00 30.00I 60.00 17.65 9.33, All 1520 1014 482 24 0.50 6.50 11.00~ 18.50 ',9.00 28.50 62.00 17.25 9.25 All C.9565 COnlr0lf %At) 950 9542 2192 389 1021 1410 252 496 748 9 25 34 0.50 1.00 0.50 6.50 6.50 6.50 11,00 11.00 11.00 17.50 18.50 18.50 19.00 19.00 19.00 25.50 31.00 29.00 62.00 0"5.50~ 65.501 16.13 17.69 17.26 8.75 9.74- 9.5011 MCn C33CS 92 49 42 1 0.50/ 3.00 11.00 11.00 19.00 25.50 42.00 14.37 8.06 Controls 470 290~ 171 9 1.001 6.00 11.00 18.00 19.00 33.00 65.50 17.44~ 10.511 All 562 339I 213 10 0.50 5.50 11.00 17.50 19.00 30.00 65.50 17.00 10.24% WOn1M1 CiSG3 406 258 140 8 0.50 6.50 11.00 16.501 19.00 25.00 62.00 15.75 8.821 Controls 868 616 239I 13 1.00 6.50 11.00~ 18.501 19.00 31.00 60.00 17.77 9.521 A11 1274 874 379 21 0.50 6.50 11.00 18.501 19.00 28.50 62.00 17.18 9.361 All CmsCf 498 307 182 9 0.50 6.50 11.00 15.50 19.00 25.00 62.00 15.53 8.711 ' COriV013 1338 906 410 22 1.00 6.50 11.00 18.50 19.00 31.50 65.50 17.67 9.84 Ak 1836 1213 592 31 0.50 6.50 11.00 18.00 19.00 29.001 65.50 17.13 9.61; Mcn Ca;c1 104 58 45 1.50 4.00 11.00 12.50 19.00 23.00 42.00 14.62 7.88! Controls 306 185 118 3 1.50 5.50 11.00 15.50 19.00 25.00 38.00 15.63 8.081 A1J 410 243 163 4 1.50 5.501 11.00 14.50 19.00 23.00 42.00 15.39 8.031 Womon Cafcf 405 250 149 6 0.50 6.50 11.00 16.50 19.00 22.50~ 57.00 15.44 7.381 Controls 750 532 211 7 ~ ?.50 6.50 11.00 17.50 1 19.00 26.00 51.00 16.52 7.90j All 1155 782 360 13 0,50 6.50 11.00 17.50 19.00 24.00 57.00 16.17 7.751 All Cases 509 308 194 7 0.50 6.50 11.00 15.50 19.00 23.00 57.00 15.28 7.471 ContrGs 1056 717 329 10 1.50 6.50 11.00 17.50 19.00 26.00 51.00 16.29 7.95~ All 1565 1025 523 17 0.50 6.50~ 11.00 17.50 19.00 24,00 S7.o0 15.99 7.82~ MM1 Ca5@f 14 4 10 0 10.50 /0.50 12.50 16.00 20.25 23.00i 23.00 16.38 5.27! COntrdf 23 17 6 1 0 11.50 11.50 17.50 19.00 19.00 38.00! 38,00 20.82 8.571 AJt 37 21 161 0 10.50 11.50 14.50 19.00 19.00 37.00 38•00 19.98 8.131 WOn1Qr1 CiSCf 63 40 22 1 3.50 10.50 14.00 19.00 19.00 24.50 31.50 17.54 5.761, COntr0ls 128 97 31 0 2.00 9.00 12.50 19.00 19.00 ~ ~ 17.15 21.00 45.00 7.171 All 191 137 53 2.00 9.00 13.50 19.00 19.00 I ' 22.00 45,00 17.27 6.771 All Cases 77 44 32 1 3.50 10.50 14.00 19.00 19.00 23.00 31.501 17.43 5.671 CCntr0lf 151 114 37 0 c.00 9.50 13.00 19.00 19.00 ^<2.00 45.001 17.70~ 7.471 All 228 958 69 1 2.001 9.50 13.50 19.00 19.00 23.00 45.00 17.631 7.00 Mcn Cases ~ 18) 11 7 0 1.50 3.00 8,50 11.00 16.SO 1s.oo 22.00 11.82 6.471 Controls ~ 129 75 53 2.50 5.50 ~ ':1.00 12.00 19.00 22.00~ 35.00~ 14.69 6.981 All 147 86 60 1 `:.50 5.00 11.00 11.00 19.00 22.00 35.00~ 14.32 6.95~ WOn1Cn Cases 58 34 22 2t 2.50 6.50 8.001 11.00 19•00 19.00 31.00 12.35' 6.091, Controls 100 77 21 1 2 2.50(t 6.50 10.00 i7.00 17.50( I 19.00 38.00 12.97 6.28( All 158 911 43 4 2.501 '.50 11.00 18•50 9.00 19.00 38.00 12.78 6.201 Afi Cases Controls Ali 76 229 305 d5 152 197 29 r4 103 2 1.50 5.00 3 2.50, 6.50 S 1.50 6.00 8.50 11.00 18.50 10.50 11.00~ 19.00 90.00 11.00 19.00 19.00 31.001 12.22 22.00 38.00 13.82 21.50 38.00 ?3.45 6.111 6.671i 6.56i GERMANY2 Men Ca:ef ~ 29 18 10 11 2.50 2.501 8.50 11.00 11.00 26.50 28.50 11.69 7.22!. EOntr0lf 65 39 25 + 1.50 5.50 6.50 11.00 12.00 17.50 33.00 11.29 5.68 ~ All 94 57 35~ 21 1.50 3.50 8.50~ 11.00 11.00 21.50 33.00 11.42 6.15~ Women Cases 113 61 52 0 1.50 7.50 11.00 11.00 11.00 21.50 32 00 12.45 6.041 Controls 98 59 38 1.50 4.00 9.50 11.00 11.00 17.50 30.50'E 10.57~ 4.91: A!1 211 120 90 1.50 5.00 10.50 11.00 11.00 20.50 32.00! 17.53 5.57! All Cases ~ t421 79 621 ; 1.50 5.50 10.50 11.00 11.00 22.00 32.00' 12.28 6.28 Controls 163! L 98 63 2 ':.50 4.50 9.50 91.00 00~ 17.50 33.00 10.86 5.21 A11 305~ 177 125 3 i,50 4.50 10.50 11.00 11.00f 21.00 , 33.00 11.49 5.74 GERMANY 3 Men CiBf3 10 3 7 0 10.50 10.50~ 10.50 71.00 11.00 11.00! 11.00 10.83 0.291 Controls 14 6 1 4.50 4.50 5.50 10.50 11.00 11.00' 11.00 8.86 2.79i A11 24 10 13 1 4.50 5.00 8.50 10.75 ':1.00 11.00 11.00 9.45 2.48` WOrnCn CiSCf t 21 12 8 1 5.501 6.50 7.50 11.00 12.25 16.50 25.50 11.46 5.39 COntrolf ~ 38~ 26 12 0i 2.50 2.50 8.50 11.00 11.00 11.00 11.00 9.21~ 3.06 All 89 38 20 2.50 4.50 7.50 11.00I 11.00 11.00 25.50 01- 92 4 9 AJI Cases 1-31 15 15 S 5.50 6.50 7.50 11.00 i7.00 16.50 25.50 . . 11.331 4.78: Controls i 52 33 18 1( 2.50 4.50 8.50 11.00 11.00 11.00 11.00 9.141 2.96 All 83 48 33 2 2.50 4.50 8.00 11.00 11.00 11.00 25.501 9.82 3.72 ITALY I MCn Cases 8 fi( 2 0 74.50 74.50 18.50 22.00 25.50 . 26.50 26•50 21.50 ' 4.85 COntt0lf 103 70 28 5~ 1.50 I 8.25 12.50 19.00 22.00 39.50 65.50 21.21 13.59: All e 6 39 5 S ' 19.00 ? 39.00 WomBn Cases 32 ! 21 .00 ~.50 4 .50 9.50 62.00 57.00 2 9.43 18.80 Controls 118 92I 21 5 2.00 8.50 7. 75 1 19.00 32.251 60.00 23.83~ 13.90 All 950 I 1131 30 7 1.00 5.50 15.50 19.00 31.00 47.50 62.00 23.01 _ 14.94 All Cases 40 27 11 2 1.00 1.50 7.50 19.00 25.00 57.00 62.00 99.89 76.65 COntroif 221 162 49 10 1.50 8.50 15.00 19,00 28.00 40.00 65.50 22.69~ 13.79 All 261 189 60 12 1.001 7•00 14.50 19.00 26.50 42.00 65.50 22.291 14.22 ~063593341 i a,

D_S1 U D Spouse, Duration (years) (non overiapping) ALL CENTERS ot.xposucv k Gscs % Co~t zols O~Ct ( OR(21 95!4 C I ( OR(3) 95% CI I HE., .i1UD<34 -52@ 1336 1.00 1 1.00 1.00 1.00 1.00 34<S1UD<42 65 103 1.58 ( 1,11- 2.26) 1.53 ( 1.05- 2.22) 1.55 ( 1.02• 2.35) 1.64 ( 1.15- 2.35) 1.62 1 1.07- 2.4s) 42<S1UD 38 80 1.04 ( 0.67- 1.61)1 1.01 ( 0.64- 1.60) 0.91 ( 0.54- 1.51) 1.14 ( 0.73- 1.77) 0.89 ( 0.54- 1.46) EXcluded/Trand1 ALL CENTERS WfTH EDUCAT 191 10NAL LEV EL AN 231 D TY 0.07 PE OF RES IDENC E 0.07 0.06 1 0.08 NE., ,i1UD<34 340 991 1.00 1.00 1.00 1.00 1.00 34<SiUD<42 47 81 1.54 ( 1.02- 2•33) 1•55 ( 1.02- 2.34) 1.55 ( 1.02- 2.35) 1.59 ( 1.05- 2.41) 1.71 ( 1.08- <^.71) 42<S1UD l 27 1 67 0.94 ( 0.56- 1.56) ~ 0.94 ( 0.56- 1.56) 0.91 ( 0.54- 1.51) 1.01 ( 0.6( • 1•69) 0.91 ( 0.53- 1.57) s:xCluded/Trand 84 199 1 0.33 1 0.32 ( 0.38 E 0.32 i 0.36 ALL CENTERS W)TH DIETAAY DATA N€., u1UD<.34 409 886 34<g1UD<42 49 69 42eS1UD 29 62 1.00 1 1.00 1.00 1.00 1.00 1.63 ( 1.07• 2.46) 1.68 ( 1.10- 2.57) 1.74 ( 1.09- 2.77) 1.67 ( 1.10- 2.53) 1.62 ( 1.07- 2.45) 0.90 ( 0.55- 1,48) 0.93 ( 0.56- 1.53) 0.88 ( 0.51- 1•53) 0.98 ( O.S9- 1.61) 0.89 ( 0.54- 1•46 ) Excluded/Trand 22 39! 0.18 0.19 0.22 ~ 0.17 0.21 FRANCE NE., :1UD<34 34eS1UD<42 42<g1UD 68 130 1.00 1.00 1.00 1.00 1.00 4 it 0.76 ( 0.22- 2.57) 0.56 ( 0.14- 2.23) 0.62 ( 0.11- 3.51) 0.78 ( 0.23- 2.65) 0.76 ( 0.22- 2.59) 5 10 1.02 ( 0.31• 3.30) 0.79 ( 0.21- 3.00) 0.80 ( 0.12- 5.22) 1.17 ( 0.35• 3.90) 0.98 ( 0.30- 3.20) EXCludad/Trand 0~ 0 1 0.81 0.61 0.63 0.77 0.78 GERMANYI NE., S1U0<34 34<81UD<.42 42<S1UD 83 217 1.OD 1.00 1.00 1.00 1.00 ~ 9 5 4.60 ( 1.39-15.20) 6.09 ( 1.45-25.54) 5.72 { 1.34-24.35) 4.96 ( 1.48-16.59) 4.72 ( 1.41-15.87) ~ 2 7 0.42 ( 0.08- 2.17)~ 0.39 ( 0.07- 2.09) 0.38 ( 0.07- 2.04) 0.43 ( 0.08• 2.22) 0.34 ( 0.06- 1.81) E`xcluded/Trend 2 0 0.27 ~ 0.32 ~ 0.37 ( 0.26 0.37 GERMANY2 NE., S1UD<34 115 149 1.00 € 1.00 1 1.00 1.00 1.00 34<$1UD<42 16 6 2.68 { 1.00• 7•22) Z 61 ( 0.96- 7.06)l 2.48 ( 0.91- 6.76) 2.68 ( 1.00- 7.22) 2.55 ( 0.94- 6.93) 42<S1UD 11 8 1•46 ( 0•53• 4•03) 1.44 ( 0.52- 3•98)l 1.46 ( 0.52- 4.11) 1.45 ( 0.53- 4.00) 1.49 ( 0.54- 4.10)~ Exclud~d/Trend 0 0 0.07 0.09 ~ 0.10 0.07 0.07 GERMANY3 HE., S1UD<34 34<31U0<42 42<S1UD 28 48 1.00 1.00 1.00 1.00 1.00 1 21 0.77 / 0.06- 9.72)1 0.76 ( 0.06-10.32) 1.40 ( 0.08-25.47) 0.80 ( 0.06-10 .18) 0.89 { 0.07-11.92) 2 2~ 2.29 ( 0•28•18•90)~ 2.28 ( 0•26•19•64) 1.70 ( 0.19-15.05) 3.23 ( 0.36-28.94) 1.70 ( 0.20-14•39) Excluded/Trand i 0 01 0.62 1 0.63 1 0.60 0.61 1 0.73 ITALY I NE., 81UD< 34 34 ~ 194 1.00 1.00 1.00 E 1.00 3 4<81UD<42 ( 3 7 1 0.70 ( 0.18- 2.65) 0.81 C, 0.21- 3.15) 0.77 ( 0.20- 3.02) 0.71 1 0.18- 2.74) 42<S1U0 ( 2 9 0.94 ( 0.18- 4,88) 1.01 ( 0.19- 5.35) 5.11) 1.12 ( 0.21• 6.10) 0.95 ( 0•18- €kcluded/Trand l 1 1 0.67 0.68 1 0.67 , 0.55 ~ ITALY 2 N€., 51U0<34 15 151 1.00 1.00 1•00 1.00 34<81U0<42 2 14 0.77 ( 0.15- 3•99) 0.93 ( 0.17- 5.09) 1.55 1 0.24-10.11) 0.82 ( 0.16• 4.23) 42<S1UD 1 5 1.07 ( 0•11•10,94) 1.09 ( 0•10•11.54) 0.00 ( 0•00-99•99) 1.17 ( 0•11-12.07) ~ :xeludad/Trend 1 3 0.84 0.99 E E 0.86 ~ 0.91 ~ ITALY 3 NE., 51U0<34 34<S1UD<42 42eS1UD ( 10 40 7.00 ° 1.00 1.00 1.00 1.00 P 1 5I 0.58 ( 0.05• 6.18)1 0.56 ( 0.05- 6.05) 1.20 1 0.07-21.06) 0.63 ( 0.06- 6.74) 0.50 ( 0.04- 6.14) 4 ~ 4/ 2.45 ( 0.45-13.46) II 3.21 ( 0.51-20.07) 2.96 ( 0.40-22.06) 2.79 ( 0.49-15.87) 2.45 ( 0.30-19.73) Exc1 udad/Trend ° I 0.54 ~ 0.45 0.31 ~ 0.46 ( 0.57 PORTUGALI NE „ 51UD<3E 34<s1U0<42 42<81UD 40 37 t.oo 1.00 6 / 7.28 ( 0.77-68,67) 7.54 ( 0.80-71.24) 3 1 4.51 f, 0.34•59,73) € € 4.75 ( 0.36•62 58) Excluded/Trend o ~ 0 0.04 - ( 0.04 ~ PORTUGAL 2 NE,, S1U0<34 34<$1UD<42 42<S1UD 26 So 1.00 1.00 I 1.00 4 2 4.i6 ( 0.64-26.81) 2.65 { 0.34-20.45) I 4.43 { 0.69-28.52) 2 1 5.60 ( 0.37•84,13) 6.96 ( 0.33-148.3) I 6.01 ( O.a1-88.21) p ~ Excludid/Trend 1) 0 0.06 ~ 0.11 ~ 0.07 SPAIN NE., S1UD<34 34<91U0<42 42<S1U0 47 100 1.00 1.00 1.00 1.00 1.00 9 25 0.81 ( 0.33- 1.97) 0.90 ( 0.36- 2.28) 0.79 ( 0.30- 2.07) 0.80 ( 0.33- 1.95) 0.80 ( 0.32- 1.98) 2 16 0.20 ( 0.04• 0.99) 0.19 ( 0.04- 0.97) 0.16 { 0.03• 0.83) 0.23 ( 0.05• 1.15) 0.23 ( 0.05- 1.11) Excluded/Trend ."3 18 0.12 ~ 0.10 O. lo ~ 0.12 E 0.14 ~ SWEDEN N€,, ~1uo<3a 34<$1U0<42 42<81UD aa 106 1.00 1.00 ; 1.00 1.00 ( 4 4 1.74 ( 0.41• 7.46) 1.87 1 0.42- 8.27) 1.78 ( 0.42- 7.64) 1.67 ( 0.38- 7.32) 2 2 1.50 ( 0.19-11•58) 1.34 ( 0.17•10.49) ! 1.59 ( 0.27-12.16) i. 1.82 ( 0.23-14.28) Excludad/Trend 0 0 0.42 ~ 0.43 ~ 0.39 0.39 ~ UNITED K)NGDOM NE,, 51UD<s34 ~ 18 114 1.00 1.00 1.00 1•00 1.00 34<$1U0<42 6 11 6-10.91) 3.17 ( 1•01- 9.99) 3•55 ( 1. 3.13 ( 0.99- 9.89) 3.94 ( 1.26-12•32) 3•54 (, i•15-10•94) 42<81U0 ~ 2 15 1 0,88 ( 0,18- 4,29) 0.87 ( 0.17• 4•46) 0.80 ( 0.15- 4.16) 1.04 ( 0.21- 5.24) 0.87 ( 0•18- 4•29) Excluded/Trend 0 ~ 0l 0.19 ~ 0.22 ~ 0.25 ( 0.18 0.19 (1) Model Include sex, center, sex'center and age (2) Model InClude sex, center, sex'ceMer, age and proportion of residential type in the last 35 yrs (REUP) (3) Model frlclude sex, center, sex'cortter, age, proportiart of residential type in the fast 35 yrs (REUP) and educational level (EDUC) (TP ubodet fncludc sex, csntcr, asx'center, a9e and durdtion otexposure to tist A a9ents (OCLAY) (5) ModN inc)ude sex, center, sex•center, age and frequency consumption of vegetables (VEGE) 63 593364- Risk estimates - Spouse

U _Q I vQ Spouse, Cumulative exposure of smoking spouse (packs/day x years) A(.L CErJTERS _t.sv~\ oS axpmut• NE., U1CS<35 35<S1CS<52 52<S1C3 Excluded/Trlndj 2361 398 0.17 _ALL CENTERS W1TH EDUCATIONAL LEVEL AND TYPE OF RESIDENCE NE., S1CS<35 35<S1CS<s52 52<S1CS Excludod/Trendl 294 ALL CENTERS WITH DIETARY DATA CR(2) 95Y. Ct { 1.09 ( 0.68- 5.76) 1.14 ( 0.66• 1.96)~ 1.00 1.00 0.97 ( 0.56• 1.69) 0.99 ( 0.57- 1.73) 1.20 ( 0.64- 2.23)1 1.22 { 0.65- 2.27) d. R(3) 95% CI OR(4) 95% CI 6 OR(S) 95'/. C) 1.00 1.00 1.00 0.99 { 0.57- 1.73) 1.ts ( 0.76- 1.87) j 1.10 ( 0.65- 7.Sa)I 1.22 ( 0.65- 2.29) 1.43 ( 0.87- 2.33) 0.92 ( 0.49- 1.73) 0.18 0.16 ~ 0.18 ~ 0.94 0.91 0.96 NE., 31CS<35 233 561 1.00 ` 1.00 1.00 1.00 ' 1.00 f 35<S1CS<.52 26 64 1.12 ( 0.67- 1.87) 1.13 ( 0.66- i.95) 1.06 ( 0.57- 1.98) 1.17 ( 0.70- 1.97) 1.10 ( 0.65- 1.84) 52<S1C5 16 37 0.94 ( 0.50- 1.76) 0.90 ( 0.47- 1.73) 1.10 ( 0.53• 2.29) 0.95 ( 0.51- 1.78) 0.92 ( 0.49- 1.73)~ ExcludedIrrend 294~ 404 0.99 0.98 ~ 0.97 f 7.00 0.95 ; FRANCE NE., S1C5< 341 76 1.13 ( 0.72- 1.76) 301 51 1.38 ( 0.85- 2.25) 35 63 124 1.00 1.00 1 1.00 1.00 1.00 35<SiCS<.52 7 17 0.89 ( 0.34- 2.30) 0.79 ( 0.29- 2.21) 0.67 ( 0.15- 2.86) 0.90 ( 0.35- 2.36) 0.87 ( 0.33- 2.26) 52<51CS 4 9 0.97 ( 0.28- 3.43) ~ 1.04 ( 0.28- 3.79) 5.15 ( 0.92-28.79)1 0.97 ( 0.27- 3.42) ) 1.01 ( 0.28- 3.61 C1Udld/Trend EX C 1Udld/Trend 3 t~ 0.85 0.86 0.95 ~ 0.83 = 0.87 GERMANY 1 NE., $1C3<.35 58 209 1.00 1.0o t.o0 1.00 1.00 35<S1C3<.52 6 6 2.65 ( 0.76• 9.18) 3.19 ( 0.73-14.04) 3.75 ( 0.84-76.74) 2.77 ( 0.79- 9.72) 2.56 ( 0.73- 9.00) 52<S1CS 2 12 0.29 ( 0.06- 1.40) 0.28 ( 0.06• 9.42)1 0.24 ( 0.05- 1.22) 0.29 ( 0.06- 1.42) 0.25 ( 0.05- 1.^<5) EXC1Udtd/Trtnd i 10 2 0.51 0.47 ~ 0.44 i 0.53 ~ 0.39 GERMANY2 Excludsd/Trend GERMANY3 142 ~ ~ Excludld/Trlndf 31 ITALY I NE., S1C3<'35 31 35<S1C5<52 2 52<81C3 3 521 195 1.00 1. 00 1.00 1.00 11 0.81 ( 0.16- 4.04) 1.03 ( 0.20- 5.23) 0.99 ( 0.19- 6.02) 0.92 { 0.18- 4.65) 7 1.92 ( 0.44• 8.26) 2.70 (, 0.60•12.20) 2.52 ( 0.56-11.42) 2.20 ( 0.50- 9.79) ExCludad/TraRd 4 8 ~ 0.57 0.49 0.49 ( 0.58 ITALY 2 NE., S1C5<r35 15 159 1.00 1.00 1.00 1.00 35<S1C3<52 1 6 1.07 ( 0.11•10.77) 1.03 (- 0.10-10.67) 1.22 ( 0.70-ta.85) 1.19 ( 0.12-12.11) 52<S1CS p ` 2 Si 2.72 ( 0.43•17.15) 3.63 ( 0.54-24.20) 15.62 ; 0.47-99.99) 3.21 ( 0.49-20.85) ExcludedIrrend ~ ." 4 1 0.35 0.26 ~ 0.37 , 0.27 ! NE., S1CS<.35 10 37 1.00 1.00 1.00 1.00 1.00 35<S1C3<52 3 5 2.05 ( 0.37-11.47) 4.84 ( 0.55-42.68)) 9.59 ( 0.51-99.99) 2.32 ( 0.40-13.32) 3.93 ( 0.54-28.74) 62<SiCS 2 2 3.01 ( 0.31-28.99) 0.79 ( 0.06•11.33)] 1.01 ( 0.05-21.41) 3.28 ( 0.33-32.43) 7.76 ( 0.41-99.99) t ExcludedIrrend 1 6~ 0.25 0.21 0.08 0.20 0.26 PORTUGALI NE., 31C5<35 42 37 1.00 ; 1.00 ~ 35<S1C3<•52 2 2.96 ( 0.24•36.31) ( ! 2.84 ' 0.23-34.31j 62 00 7 52<S1CS 5 1 6.74 ( 0.69•65.38) ) € 4 6.47 ( 0.6 - . I ~ Excluded/Tnnd ~ 0 0 0.07 ( 0.07 PORTUGAL2 NE,, SiCB<35 25 35<S1CS<52 E 3 52<S1CS 4 50 1.00 1.00 1.00 t 31 2.50 ( 0.38•16.45) 1.52 ( 0.21-10.82) 2.65 ( 0.41-17.20)1 0199.99 ( 0.00-99.99) 99.99 ( 0.00•99.991 99.99 ( 0.00-99.99) ~ /Trtndl t Excluded 01 0.01 t 0.01 ~ ~ 0.01 ~ SPAIN NE., S1CS<35 35<S1C8<52 52<SiCS 45 100 1.00 1.00 1.00 1.oD t.o0 7 26 0.67 (, 0.26• 1.70) 0.71 ( 0.27- 1.86) 0.67 ( 0.25- 1.76) 0.71 ( 0.27- 1.84) 0.65 ( 0.25- 1.69) ~ 8i 12 1.20 ( 0.41- 3.54) 1.18 ( 0.39- 3.57) 1.27 ( 0.41- 3.90) 1.18 ( 0.40• 3.47) 1.10 ( 0.37- 3.26) Excludld/Trlndl /3! 211 0.82 ~ 0.73 0.72 0.80 I 0.72 , SWEDEN NE., S1CS<s35 35<S1CS<52 82<S1CS 61 106 1.00 1.00 j 1.00 1.00 3 2 2.89 ( 0.44-19.03) 2.88 ( 0.43•19•35) 2.95 ( 0.45-19.36)- 3.10 ( 0.47-20.42) 2 3 1.52 ( 0.23- 9.92) 1.56 ( 0•24-10.26)l 4 1.52 ( 0.23- 9.92) 1.64 ( 0.25-10.83) ExClUdtd/Trmd 4 1 0.35 € 0.04 ~ ~ 0.35 0.30 - Exc1 udod/Trend 26 140 t I (1) Model Indudo sex, center, scx'center and age (2) Mode( fndude s" center, sex'center, age and proportion of residential type in the last 35 yrs (REUP) (3) Model indude sex, center, sex'center, age, proportion of residential type in the last 35 yrs (REUP) and educational Ievel (EDUC) (4) Model indude sex, center, sex'center, age and duration of exposure to list A agents (OCLAY) (5) Model Include sex, center, sex'canter, age and frequency consumption of vegetables (vEr,E) 4 Cases ~ Conssols 4 OR(1) 95X Ct I 350 1017 1.OD Risk estimates - Spouse

D_S1 UD Spouse, Duration (years) (non overlapping) MEN ONLY Lw.lotucposuce Gss I Controls OR(91 95Y.CI OR(2) 95•/.Ct OR(3 95% CI E OR(4 95%Cf k OR(5) 95%CI ! 14E./ 51UD<.34 131 521 1.00 1.00 1.00 1,00 1.00 34<S1UD<.42 1 5 1.34 ( 0.13-13.56) 1.69 ( 0.75-19.42) 0.00 ( 0.00-99.99) 1.42 ( 0.14•14.46) 2.03 1 0.16-25.57) 42<S1UD 1, 4 0.76 ( 0.07- 6.38) 0.68 ( 0.06- 7.64) 0.00 ( 0.00•99.99) 0.74 ( 0.07- 8.13) 0.80 ( 0.07- 9.24) Excludrd/rrrnd 0~ 1 0.98 0.93 ~ 0.94 1.00 0.99 WOMEN ONLY 'iE.' S1U0<34 389 815 1,00 1.00 1.00 1.00 ; 1.00 34<S1U0<42 64 98 1.58 ( 1.10. 2.27) 1.52 ( 1.04- 2.22) 1.56 ( 1.02- 2.37) 1.64 ( t•14• 2.36) 1.58 ( 1•04- 2.41) 42<S1U0 37 76 1.06 ( 0.68- 1.66) 1.02 ( 0.64- 1.64) 0.94 { 0.56- 1.58) 1.17 ( 0.74• 1.84) 0.87 ( 0.53• 5.46) E fxcZudad/Trend 191 22 0.07 0.06 0.08 0.06 0.08 ~ POPULATION BASED STUDIES NE,d ."i1U0<.34 34<S1UD<42 42<SiUD 319 865 1.00 1.00 1.00 1•00 1.00 35 48 1.71 ( 1.04- 2.83) 1.78 ( 1.07- 2.98) 1.98 ( 1.12- 3.50) 1.79.( 1.08- 2.97) 2.67 ( 1.40- 5.08) 20 33 1.08 ( 0.58- 2.02) 1.13 ( 0.60- 2.11) 1.03 ( 0.52- 2.05) 1.55 ( 0.61- 2.17) 1.08 ( 0.53- 2.20) €a-cludadIrrona 4~ 4 0.11 0.11 ~ 0.15 0.09 0.11 HOSPITAL BASED STUDIES NE,1 81U0<34 34<S1U0<.42 42<S1UD 191 357 1.00 1.00 1.00 1.00 1.00 24 44 1.20 ( 0.68• 2.11) 0.96 ( 0.50- 1.82) 0.80 ( 0.37- 1.72) 1.22 ( 0.70• 2.15) 0.76 ( 0.39- 1.51) 16 32 1.01 ( 0.51• 2.00) 0.83 ( 0.39• 1.80) 0.68 ( 0.27- i.70) 1.16 ( 0.58- 2.33) 0.67 ( 0.30- 1.49) ~cludad/7rend 15 19 0.65 0.67 0.60 ~ 0.64 0.68 WITHOUT OCCASIONAL SMOKERS NE.r S1UD<•34 387 939 1.00 1.00 1.00 1•00 1.00 34<S1UD<42 48 83 1.41 ( 0.94- 2.13) 1.31 ( 0.85- 2.04) 1.38 ( 0.85- 2.24) 1.47 ( 0.98- 2.23) 1.31 ( 0.80- 2.14 ) ~ ~ 42<S1UD 34 61 1.12 ( 0.69. 1.82) 1.11 ( 0.66- 5.85) 1.04 { 0.60- 1.80) i 1.26 ( 0.77- 2.06) 0.91 ( 0.52- 1.58 ) ~rcludrd/Trand l 17~ 21j 0.16 0.16 ~ 0.20 0.15 0.18 AGE t45 YEARS NE., S1UD<34 34<S1UD<42 160 354 1.00 1.00 1.00 1.00 1.00 3 2 2.81 ( 0.35-22.42) 2.47 ( 0.25-24.77) 6.74 ( 0.27-99.99) 2.83 ( 0.35-22.65) 2.35 ( 0.20-27.97) ~ ! ~ Exc1 udrd/Trsnd 2 5 0.33 1 0.30 0.31 0.33 ~ 0.33 AGE 55-64 YEARS NE,f S1UD<34 167 493 1.00 1.00 1.00 1.00 1.00 34<S1UD<42 33 45 1.88 ( 1.10- 3.19) 1.70 ( 0.96• 2.98) 1.48 { 0.79- 2.78) 1.93 ( 1.13- 3.30) 1.83 ( 0.98- 3.44) 42<S1UD 5 1.50 ( 0.32• 7.00) 1•58 ( 0.34- 7.38)I 2.29 ( 0.39-13.39)1 2.07 ( 0.40-10.73)1 1.03 ( 0.16- 6.55) Excluded/rrendl 91 0.02 0.02 I 0.02 ~ 0,02 0.02 I AGE 65+ YEARS NE., S1U0<34 201 489 1.00 1.00 1.00 1.00 1.00 ~ 34<S1UD<.42 29 56 1.39 ( 0.83- 2.34) 1.48 l, 0.86- 2.53) 1.84 ( 1.00- 3.40) 1.42 ( 0.84- 2.40)~ 1.50 ( 0.83- 2.74) ~ 42<S1UD 35 75 1.01 ( 0.64- 1.61) 0.96 ( 0.59- 1.57) 0.80 ( 0.46- 1.39) 1.09 ( 0.68- 1.75)I 0.88 { 0.52• 1.49) Z~xcluded/Trrndl 10! 9 0.49 ~ 0.50 1 0.52 0.48 0.52 HISTOLOGICALLY CONFIRMED DIAG NO SIS NE., u1U0<34 511 1336 1,00 1.00 1.00 1.00 1.00 34<S1UD<42 82 103 1,55 ( 1.08- 2.22) 1.49 ( 1.02- 2.19) 1.54 ( 1.01- 2.35) 1.60 ( 1.11- 2.30) 1.61 ( 1.06- 2.44, 42<S1UD 351 80 0.98 ( 0.62- 1.53) 0.95 ( 0.59- 1.52)~ 0.94 ( 0.56- 1.58) 1.07 ( 0.67- 1.69) 0.92 ( 0.56- 1.51) €xc2uded/Trendl I 191 23 0.13 0.12 1 0.15 I 0.12 1 0.14 I SQUAMOUS CELL CARCINOMA NE.E S1U0<34 86 1336 1.00 1•00 1.00 1.00 1.00 34<S1U0<42 13 103 1.91 1 , 0.97• 3.75) 1.33 ( 0.60• 2.97) 1.56 ( 0.68- 3.59) 1.97 ( 1.00- 3.89) 1.46 { 0.61• 3.491 42<S1UD 80 1.26 ( 0.53- 3.04) 1.13 ( 0.44- 2.87) 0•96 ( 0.34• 2.67) 1•35 ( 0.56- 3.26) 1.23 ( 0.47•3.18) €xcludad/Trrnd 23 0.11 0.11 I 0.14 0.11 [ 0.12 SMALL CELL CARCINOMA NE., 51U0<•34 54 1336 1,00 1.00 1.00 ; 1.00 1.00 34<S1UD<.42 8 103 2.62 ( 1.11- 6.18) 2.38 ( 0.96- 5.90) 2.36 ( 0.88- 6.35)1 2.77 ( 1.16. 6.59) 2.64 (, 1.05- 6.65) 42<S1U0 6 80 1.47 ( 0.56- 3.84) 1.50 ( 0.57- 3.95) 1.58 ( 0.58• 4.29)1 1.49 ( 0.57. 3.94) 1.14 ( 0.41- 3.23) 1 Excludad/Trrndl 2 23 0.06 0.07 1 0.09 0-06 0.06 ADENOCARCINOMA NE., S1UD<34 276 1336 1.00 1.00 1.00 1.00 1.00 34<S1U0<42 28 103 1.29 f 0.80. 2.08) 1.35 ( 0.82- 2.21) 1.34 ( 0.77• 2.34)1 1.33 ( 0.83• 2.15) 1.39 ( 0.81- 2.38) 42<S1UD 19 801 1.04 ( 0.59- 1.85)E 1.01 ( 0.55- 1.86) 1.13 ( 0.58- 2.20) 1.16 ( 0.65• 2.07) 1.02 ( 0.54- 1.91) ~ Excluded/Trrnd 10 23~ 0.42 ~ 0.41 0.46 1 0.42 i 0.44 OTHER NE.f S1UD<e34 95 1336 1.00 1•00 1.00 1.00 1 .00 I 34<s1uD<.az I ° 13 103 1.75 ( 0.90• 3.41) 1.98 ( 1.00• 3.89) 1.96 { 0.93- 4.12) ~ 1.83 ( 0.94- 3.57) 2 t2 ( 1.00- 4.49) 42<s1uD k 80 0.43 ( 0 .13• 1.44) 0.44 ( 0.32 ( 0.07- 1.41) 0.13• 1.50) 0.46 ( 0.14- 1.56) 0.35 (, 0.08• 1.50) €xcludrd/Trend ~ 4 <-3 0.85 O.B6 ' 0.87 1 0.82 € O.BB g7544 OF LIFESPAN IN RURAL AREA OR INTERMEDIATE CITIES NE., S1110<34 208 512 1.00 1.00 1.00 1 1.00 1.00 34<$1U0<.42 30 3-2 2.51 l, 1.39• 4.54) 2 51 ( 1.39- 4.54)~ 3.27 ( 1.66- 6.42) 2.59 ( 1.43- 4•69) 2.23 ( 1.20• 4.15) 42<S1UD 15 27 1.12 ( 0.54• 2.32) ~ 1.12 ( 0.54. 2.32) 1.04 ( 0.47- 2.27)~ 1.16 ( 0.56- 2.41)' 1.12 ( 0•53- 2.37) fxCludtd/Trtnd 3 4 0.02 I 0.02 ~ 0.03 0.02 ~ 0.03 ~ >7554 OF LIFESPAN IN URBAN AREA NE., S1UD<34 193 592 1,00 1.00 1.00 1.00 1.00 34e$1UD<.42 24 59 { 1.14 ( 0.66• 1.96)' 1.14 ( 0.66• 1.98) 0.90 ( 0.48- 1.69) 1.19 ( 0.68- 2.08) 1.39 ( 0.71- 2.71) 42<S1UD 16 46 0.78 ( 0.41. 1.52)I 0.78 ( 0.41- 1.52) 0.66 ( 0.31- 1.40) 0.93 ( 0.47- 1.84) 0.67 ( 0.31- 1•44) cXCllidld/rrrnd I l !1~ 14 0.85 j 0.85 0.85 0.96 0.83 (1) Model (nUudo sex, center, sex'center and age (2) Model fnGude sex, center, sex'center, age and proportion of residential type in the last 35 yrs (REUP) (3) Model Include sex, center, sex'center, age. propottion of residential type in the last 35 •yrs (REUP) and educational level (EDUC) (4) Model Jnclude sa.x. center, sex'centeq age nnd duratlon of exposure to list A agents (OCL41' (5) Model Include sex, center, sex'center, age and frequency consumption of vegetab;es (VEGE) 22063593365 Risk estimates- S)zos.fss

D ~1 DH Spouse, Duration (hours/da-v x years) ALL,CENTER3 Lav.l of.xposur. Cas.s - Controls I I OR(1) 95X C! OR(2) 95% Cl OR(3) 95% CI ) OR(4) 95% CI ~ OR(5) 95% CI ( NE., S1DH<135 d62 1174 1.00 1.00 1.00 1•00 1.00 135<S1DH<223 44 81 1.26 ( 0.84- 1.91)~ 1-42 ( 0.91- 2.20)~ 1.34 ( 0•81- 2.21) 1.36 ( 0.89• 2.07) ~ 1.50 ( 0.93• 2.42) 223<81DH 41 53 1.89 ( 1.19- 3.00) 1•86 ( 1.13- 3.08) 1.58 ( 0.91- 2.75) 1.92 ( 1.21- 3.06) 1.59 ( 0.88• 2•88) EkclUdid/Trrnd( 1031 2341 0.01 0.01 0.01 0.01 1 0.01 I ALL CENTERS WiTH EDUCATIONAL LEVEL AND TYPE OF RESIDENCE NE., S10H<•135 290 846 1•00 1.00 1.00 1.00 1.00 135<S1DH<223 31 55 1 .35 ( 0.82- 2.22) 1.35 ( 0.82- 2.22) 1.34 ( 0.81- 2.27) 1.45 ( 0.87- 2.39) 1•63 ( 0.94- 2.82) 223<S1DH ( 25 43 1.57 ( 0.90- 2.73) 1.58 ( 0.91- 2.74)~ 1-58 ( 0,91- 2.75) 1.59 ( 0.91- 2.76) 1 i 1.64 ( 0.86- 3.11) EXCludtd/Trtnd i 152 394~ 0.13 1 0• 13 ~ 0.14 0.13 0.15 ALL CENTERS WITH DiETARY DATA NE., 810H<135 351 744( 1.00 1.00 `: 1 1•00 1•00 I 1.00 135<SiDH<223 36( SO 1.52 0.94- 2.45) ( 1.67 ( 1.02- 2.74) 1.60 ( 0.92- 2.78) 1.60 ( 0.99- 2.60) 1.50 ( 0.93- 2.42) 3.?3<StDH 23P 33 1 1.61 0.89- 2.92) ( 1.72 ( 0.94- 3.13) i 1.63 ( 0.86- 3.10) 1.64 ( 0.91- 2,97) 1.59 ( 0.88• 2.88) €xclud#d/Trend 991 229 0.03 1 0.03 0.04 1 0.03 0.04 FRANCE N€., S1DH<13s 66 129 1•00 1•DO 1,00 1,00 1•00 135<S1DH<223 3 13 0.48 ( 0.13- 1.81) 0•46 ( 0.09- 2.27) 0.53 ( 0.06- 4.95) 0•52 ( 0.14- 2,00)~ 0.47 ( 0.12- 1•77) 223<S1DH 2 3 1.54 ( 0.24- 9.74) 2.16 ( 0,33•14•28) 1.67 ( 0.13-21.91) 1.58 ( 0.25-10,00)~ 1.56 ( 0.25- 9.90) EXC1Uded/Trrnd 3 6 0.64 0.85 : O.ST ~ 0.63 ~ 0.63 GERMANY 1 NE., SiDH<133 56- 203 1.00 1.00 1•00 1.00 1.00 135<31DH<0223 3 6 I 1.42 ( 0.32- 6•23) 1• ( 56 0.33- 8) 7.2 1.50 ( 0.31- 7.25) 1.53 ( 0.34- 6.79) 1.42 ( 0.32- 6.37) 223<S10H 1 2 3 1.43 ( 0•22- 9.22)1 1.31 ( 0•20• 8.69) 1.06 ( 0.15- 7.47) 1.47 ( 0.23- 9.44) 1.30 ( 0.19. 8,75) 1 1 Excludid/Trtnd r 17 0.57 ! 0.65 0. 76 0.55 1 0.57 ( GERMANY2 NE., S1DH<136 135<81Dt!<223 223<S10H 105 152 1.00 1.00 1.00 1.00 1 1.00 14 5 2.84 ( 7.02• 7.88) 2.88 ( 1.03- 8.03) 2.82 { 1•01- 7.87j 2.83 ( 1.02- 7.84)) 2.88 ( 7.04- 7.98) 6 3 2.26 ( 0.53- 9.67) 2.23 ( 0.52• 9.67)I 2.12 ( 0.48- 9.30) 2.27 ( 0.53- 9.70)1 2.29 ( 0.54- 9.79) Excludrd/Trtnd 17 2 0,04 ~ 0.04 ~ 0.05 0.04 1 0.04 GERMANY3 NE-, 310H<13s t23<810N 27 48 1.00 1.00 1.00 1.0o 1.00 i 1 1 1 1.91 ( 0.11-33.94) 99.99 ( 0.00-99.99)~99.99 ( 0.00-99.99)~ 2.39 ( 0.13•45.28) 2.20 ( 0.12-39.52) c`xcludad/Trendl 3 3 ~ 0.65 0.97 ~ 0.98 ~ 0.63 O•59 ITALY 1 N€-, 310H<•135 31 191 1.00 1.00 1.00 1.00  135<S1DH< 223 ~ 1 13 0.26 ( 0.03- 2,12) 0.37 ( 0.04- 3.10) 0.37 ( 0.04- 3.11) 0.35 ( 0.04- 2.91) 223<S1DH 3 10 1•10 ( 0.28- 4,42) 1.36 ( 0.33• 5.56) 1.28 ( 0.31• 5.29) 1•15 ( 0.29- 4.64) fxcl4drd/Trrnd 5I ° € 0,61 1 0.70 0.71 0.60 ~ I ITALY 2 NE., S10H<•135 135<S10H<0223 223<S1uH Ezc1 udtd/Trtnd ITALY 3 NE,, c10H<13S 135<S1DH<223 223<S1nH 1.00 1.00 3.06 ( D.19-48.11) 0.49 ( 0.06- 4.26) 2.31 ( 0.18-29•49)1 1.92 ( 0•32•11-39) 1 71 29 1.00 1.00 ?.00 1.00 1.00 3 5 7.48 1 0.23- 9.51)f 1.52 ( 0.23- 9.98) 7.77 1 0.12-70.97) 1.31 { 0.79- 8.96) 2.32 ( 0.28-19.17) 31 1 12.59 ( 0.77-99•99) 99.99 ( 0.00-99.99) 99.99 ( 0.00•99.99) 12.07 ( 0.74-99.99) 7.32 ( 0.40-134.5) EXCludad/Trtntl- 31 15 0•11 ~ 0.08 ~ 0.08 ~ 0.13 ~ 0.11 PORTUGAL 1 HE., S10H<135 135<S10H<223 223<SiDH 37 30 ;.OC ' t.OC 3 4 0.59 ( 0.10- 3.34) ~ o.so ( 0.11- 3.a2) 9 3 3.48 ( 0.80•15.08) ~ F 3.43 ( 0.60•14.73) c"xcludtd/Trrnd 01 21 f 0.19 0.18 I ~ I i PORTUGAL 2 N€., S10H<135 135<S1DH<223 223<S1DH 24 49 1.00 1.00 ((( ( 1.00 / ~ 3 1 10.76 ( 0.92-126.5) 16.72 ( 0.88-99.99){ (10.38 ( 0.88•121.9)I 3 0 99.99 ( 0.00•99.99) 99.99 ( 0.00-99.99)!' ) 99.99 ( 0.00•99.99 lf szeitldtd/7rrnd s~ 3 0.02 - 0.01 ~ lll ~ 0.02 ~ j SPA1N NE., u10H<135 35 87 1 00 1.OD 1.00 1.00 1.00 135<610H<•223 9 20 F 15 ( 0.46- 2.88) 1.38 3.61) 1.21 ( 0.44• 3.34) 1.25 ( 0•49• 3.21) 1.16 ( 0,46- 2.95) 223<S10H 8 1 1.12 ( 0,43• 2,95) 1,21 ( 0.45• 3,27) 1.19 ( 0.43• 3.25) 1.10 ( 0.42• 2.88) 1.07 ( 0.40- 2•83) fzeluded/Trend 19 31 0.75 0.78 1 0.79 ~ 0.77 1 i 0.82 f SWEDEN 51DH<.135 NE., 135<S10H<223 223iSi0H 59 109 1.00 1.00 7.00 1.00 4 2 3.67 1 0.62-21.05) 3.48 ( 0.59-20.57) 3.80 ( 0.65-22 A7) 3.47 ( 0,58-20.70) 2 1 3.66 ( 0.31-43.31) 3.81 ( 0.31•46.97) E 3.78 ( 0.32-44.41) 3.95 ( 0•34•46.39) Szcl udrd/Trend 5 0 0.10 0.10 I ~ 0.09 ~ 0.10 UNITED KINGDOM (1) Modcl irtdudc sox, center, sex•ccnter and age s2) Model (ntlude sex, center, sex'csnter, 3ge and proportion of residential type in the last 35 yrs (REUP) (3) Model (ndude sex, center, sex'center, 39e, proportlon of residenGal type in the last 35 yrs (REUP) and educational level (EDUC) ,9t r.fodeY trteiudese.r, can;er, sex'certte~, age and dural;on of exposure to hst A agents (OCLAY) (5) Model fnctude sex, center, sex'center, age and frequency consumption of vegetables (VEGE) Risk estimates - Spouse

C - SlAV Spouse, Average exposure (cigarettes/day) ALL CEN7ERS LwN ol un Casms I Controls i OR(1 95% Cl Non exposed 297 778 1.00 0<S1AVe10 206 10<$1AV< 411 1.10 ( 0.86- 1.40) 18 25 63 0.58 ( 0•35- 0.94) 35 55 1.37 ( 0•85• 2.20) 18<$1Av Ercludod/Trsnd 87 215 0.88 ALL CENTERS WITH EDUCATIONAL LEVEL AND TYPE OF RESIDENCE OR(2) 95% CI OR 3 95 % Cl ) OR(4 95 % CI OR(5 95'. CE ( 1.00 1.00 1.00 1.00 1.09 ( 0.84- 1.42) ~ 1.04 { 0.76• 1.41) 1.12 ( 0.88- 1,44) 1.08 ( 0.81- 1•43) 0.53 ( 0.31- 0.90) 0.50 ( 0.28• 0.91) 0.59 ( 0.36- 0.96) 0.50 ( 0•29- 0.87) 1.31 ( 0.80. 2.15) 1,36 ( 0.78. 2.47) 1.40 ( 0,87• 2.25)~ 1.18 ( 0.66- 2.05) 0.89 ~ 0.90 0.88 0.87 Non m%p03ltl 179 562 0<$1AV<10 135 292 10<S1AV <18 17 65 18<S1AV 24 38 Excludtd/Trondl 143 ALL CENTERS W1T'N DIETARY DATA Non exposed 0<S1AV<10 10<S1AV<a18 18<S1AV t°xcludad/Trend FRANCE Non exposed 0<S1AV<.10 10<S1AV<18 98<S1AV Exc2uded/Trsnd GERMANYI 1.00 1.07 0 .51 1.39 0.40 1.00 1.08 0.51 1.15 0.45 65 1.00 7.00 ( 0.79- 1•45} 1.07 ( 0.79- 1.45) ( 0.28- 0.92) 0.51 ( 0.28- 0.93) ( 0.78- 2.47) 1.38 ( 0.78• 2.46) 0.41 1.00 ( 0.82- 1.43) 1.08 ( 0.80• 1.44) ( 0.30- 0.89) 0.55 ( 0.32- 0.96) ( 0.66- 2.00) 1.22 ( 0.70- 2.13) 0.44 53 0.91 ( 0.46- 1.78) 13 0.41 f, 0.11- 1.56) 17 0.51 ( 0.17- 1.57) 3 0.13 1.00 1,00 1.04 ( 0.76- 1.41) 1.08 ( 0.80- 1.48) 0.50 ( 0.28- 0.91) 0.52 ( 0.29- 0.94) 1.38 ( 0.78• 2.47) 1.42 ( 0.79- 2.53) 0•39 0.40 1•00 1•00 1,04 ( 0.74• 1.45) 1.10 ( 0.83- 1.46) 0.52 ( 0.28• 0•98) 0.52 ( 0.30- 0.90) 1.44 ( 0.76• 2.72) 1.18 ( 0.68- 2.04) 0.43 E 0.46 1.00 1.00 0.63 ( 0.22- 1.77) 0.89 ( 0•45• 1.77) 0•44 ( 0.08- 2.52) 0.41 ( 0.10- 1.57) 0.73 ( 0,18• 3.04) 0.50 ( 0.17- 1.54) O. 12 0.13 1.00 1.09 ( 0.78- 1.52) 0.53 ( 0.28- 0.99) 1.43 ( 0.76- 2.70) 0.41 1.00 0.89 ( 0•45• 1.75) 0.39 ( 0.10- 1.51) 0.53 ( 0.17• 1.60) 0.14 Non exposod 94 153 1.00 1.00 1.00 1.00 1.00 0<S1AV< .10 22 49 1.26 f, 0.62- 2.56) 1-21 ( 0.54- 2.70) 1.15 ( 0.51- 2.59) 1.30 ( 0.63- 2.67) 2.89) 1.40 ( 0.68- 90<S1AV<. 18 5f 11 1.42 f, 0.42- 4.80) 1.64 1 0.45- 5.94) 1.61 ( 0.44• 5.86) 1.50 ( 0•44• 5.08) 1.64 ( 0.47- 5.69) 8<S1AV 1 3! 6 0.95 ( 0.21- 4.26) 0.91 ( 0.19• 4.24)1 0.90 ( 0.18• 4.45) 0.98 ( 0.22- 4.43) 1.03 ( 0.23- 4.70) fxcludsd/Trond 12I f0 0.81 0.99 0.92 0.84 0.75 GERMANY2 Non exposed 0<S1AV<10 10<S1AV<18 18<S1AV €xcludod/Trond GERMANY3 Non exposetl 66 98 1.00 1.00 100 . 1.00 1.00 52 43 1.22 ( 0.69- 2.17) 1.14 ( 0.63- 2.04 ) 1.07 ( 0.59- 7.93) 1.22 ( 0.68- 2.17) ( 1.20 0.67- 2.14) 5 14 0.33 ( 0.11- 1.00) 0.33 ( 0.11• 1.01) 0.31 ( 0.10- 0.99)i 0.33 ( 0.11- 1.00) 0.33 ( 0.11- 5.01) 5 6 0.80 ( 0.22• 2.87) 0.80 ( 0.22- 2.92) 0.82 ( 0.22• 3.04)I 0.79 ( 0.22• 2.85) 0.80 ( 0.22- 2.87) l 141 2 0.22 0.22 0,22 0.22 0.22 22 35 1.00 7.00 1.00 1.00 1.00 ~ 0<$tAV<.10 E 15 0.71 ( 0.22- 2.34) 0.76 ( 0.22- 2.63) 0.50 f- 0.13- i.90) 0.78 ( 0.22- 2.73) 0.57 ( 0.16- 1.97) 90<$tAV<1 8 ( 0 1 0.00 ( 0.00•99.99) 0.00 ( 0.00-99.99) 0.00 ( 0,00-99.99) 0.00 ( 0.00-99.99) 0.00 ( 0.00-9 9.99) 18<S/AV 1 ~ 0 99.99 ( 0.00-99.99) 99.99 ( 0.00-99.99) 99.99 ( 0.00-99.99) 99.99 ( 0.00•99.99) 99.99 ( 0.00-99.99) :j sxcluded/Trsndi 1 0.61 0.63 0.93 0.60 0.75 ITALY I mxposed Non 16 123 1.00 1.00 1.00 1.00 0<S1AV<10 ',7 69 1.01 ( 0.43- 2.38) 1.30 1 0.53. 3.18) 1•14 ( 0.46. 2.82) 1.28 ( 0.52- 3.1) 10<S1AV<18 1 10 0.42 { 0.04- 3.85) 0.60 ( 0.06- 5.72) 0.50 ( 0.05- 4.79} 0.53 { 0.06- 4.96) 98<S1AV 21 6 1.41 ( 0.23. 8.54) 1.95 ( 0.31-12.12) 1.72 ( 0.27•10.83) 1.74 ( 0.28-10.66)1 cxeludid/Trand 4 13 0.99 0.86 0.87 1.00 ITALY 2 Nan mxposed 10 106 1.00 1.00 1 1.00 ° 1.00 t O<S1AV< 10 52 0.44 ( 0.13- 1.48) 0.35 ( 0.09- 1.36) 0.48 ( 0.09- Z57) 0.43 ( 0.13. ~ 10<$lAV<18 0 4 0.00 ( 0.00•99.99) 0.00 i, 0.00-99.99) 0.00 ( 0.00•99.99) 0.00 ( 0.00-99•99) 18<S1AV 2 6 1.46 ( 0.23- 9.41) 1.95 ( 0.28-13.83) 2.02 (, 0.11•35.61)~ 1.28 ( 0.20- 8.08) Exc2 uded/Tivnd 1~ ~ 5 0.91 o.s4 0.80 0.96 ITALY 3 _ Non exposea 4 23 1.00 1.00 1•00 1.00 1.00 0<S1AV<10 11 3.65 ( 0.76-17.45) 3.41 ( 0.67-17.30) 1,76 ( 0.27-11.63) 4.07 ( 0.80-20.64) 4.41 ( 0.77-25.28) 10<S1AV<18 5 0.83 ( 0.07-10.31) 0.79 ( 0.06-10.39) 0.36 { 0.02- 6.63) 0.37 { 0.01- 9.01) 0.79 ( 0.06-11.23) 18<S1AV 6.50 ( 0.20-99.99) 99.99 ( 0.00-99.99) 99.99 ( 0,00•99.99) 6.12 ( 0.19•99.99) 99.99 ( 0.00-99.99) €xcludad/Trsnd 10 0.62 0.59 0.79 o. 78 0.65 PORTUGALI Non mxpdLfC 22 1.00 1.00 0<S1AV<10 ) 12 1.04 1, 0.36- 2.95) 1.02 ( 0.36• 2.91) 10<6 1AV<18 i 4 4.97 ( 0.48-51.29) 4.87 ( 0-48-49.75) 18<S1AV l 3 99.99 (, 0.00•99.99) 99.99 ( 0.00-99.99) €xcludid/Trsnd 11 0.04 ~ 0.04 E PORTUGAL2 Non expo9md 16 38 1.00 1.00 ! 1.00 0<S1AV<10 11 10 5.26 ( 1.35-20.42) 2.65 ( 0.56•12.47)i 4.77 (, 1.21-18•82) 18<S1AV 3~ 2~ 6.70 ( 0.82•54.52) 4.91 ( 0.54-44.59)I 7 6.35 ( 0.79-50.92) €xcludmd/Trend 3~ i, 31 0.09 ( 0.07 ( 0.09 1 ~ SPA)N Non expOsetl 23 0<S1AV<10 21 10<S1AV<18 4 18<SiAV : €xcluded/Trrnd 17 50 1.00 1.00 1.00 1.00 7.00 58 0.79 ( 0.37- 1.69) 0.86 ( 0.39- 1.92) 0.82 ( 0.35• 1.88)1 0.83 ( 0.38- 1.80) ~ 0.77 ( 0.36- 1•66) 16 0.41 (, 0.10- 1.61) 0.44 ( 0.11- 1.75) 0.47 ( - 0.11- i.90) 0.42 ( 0.11- 1.67) 0.42 ( 0.77- 1.66) 8 2.03 ( 0.62- 6.66) 2.29 { 0.65- 8.00) 2.33 ( 0.66• 8.23)~ 2.05 ( 0,62- 6.75)~ 2.19 ( 0.65- 7.32) 27 0.53 0.59 0.52 0.53 0.46 SWEDEN Non exposed 0<S1AV<10 10<S1AV<18 18<S1AV cxcluded/Trend UNITED KINGDOM 38 62 1 00 1.00 ! 1.00 E 1.00 24 39 7.14 ( 0.57• 2.26) 1.13 ( 0.56- 2.26) 1.16 { 0.58- 2.30) 1.18 ( 0.59- 2.37) 3 8 0.61 ( 0.15- 2.52) 0.64 ( 0.15- 2.70) ~ 0.64 ( 0.16- 2.65) 0.57 ( 0.14- 2.36) 3 3i 2.19 ( 0.40-12.15) 2.19 ( 0.38-12.51) ttt 2.21 ( 0.40-12.24) 2.41 ( 0.42-13.83) 2 0 I 0.71 0.70 E 0.67 1 0.70 (1) Model indude sex, center, sex•cen(er and age (2) Model Include sox, center, sex'center, age and proportion of residential type in the last 35 yrs (REUP) (3) Model include sex, center, sex'center, age. proportion of residential type in the last 35 yrs (REUP) and educational level (EDUC) (41 htadct (nC(ude aCx cen(er, SC 'c6n(Cr, age and duraaan o(expvsure to list A agenta (OCLAY) (5) Model indude sex. center, sex'center, age and frequency consumption of vegetables (VEGE) Risk estimates - Spouse

clus Childhood 0-98 yrs, Smoking parent years PTALY 2 Total Exposed Unexposed Exduded P.1in P10 ~ Q1 { Median ~ 03 P90 Max ; Mean Std MCn C8.C3 3 1 2 0 0.50 0.50 0.50 0.50 0.50 0.50 0.50 0.50 CGntt011 97 55 41 1 1.00 5.50 14.50 19.00 ~ 21.50 35.50 65.50 19.80 11.48~ AH 100 56 43 1 0.50 4.00 14.25 19.00 20.25~ 35.50 65.50i 19.46 11.66 WOmen Cases 16 12 4 0 18.50 19.00 19.00 20.00 25.00 27.50 38.00 22.58 5.72 Controls 76 39 36 1 1.00 6.50 18.00 19.00 23.00 33.50 45.00 20.17 9.08 Att 92 51 40 1 1.00 13.50 19.00 19.00 23.00 31.50 45.00 20.74 8.42 AS COSe3 19 13 6 0 0.50 18.50 19.00 19.00 25.00! 27.50 38.00 20.88 8.21 CCnlfOlf 173 94 77 2 1.00 6.00 16.00 19.00 22.50f 34.50 65.50 19.95 10.501 AN 192 107 83 2 0.50 6.00 17.50 19.00 23.00 34.50 65.50 20.07 10.22 CtALY 3 MCn Cases 1 0 1 0 COnl101f 12 5 0 5.50 5.50 16.50 19.00 1 19.00 19.00 19.00 15.80 5.861 AU 13 5 8 0 5.50 5.50 16.50 19.00 19.00 19.00 19.00 15.80 5.86 WCR1M1 cases 15 9 6 0 8.50 8.50 19.00 19.00 19.00 27.00 27.00 17.56 5.76 Controls 38 26 12 0 5.50 8.50 19.00 19.00 19.00 38.00 42.00 19.92 8.41 All 53 35 18 0~ 5.50 8.50 19.00 19.00 19.00 27.00 42.00 19.31 7.81 AH cases 18 9 7 0 8.50 8.50 19.00 19.00 19.00 27.00 27.00 17.56 5.76 Controls 50 31 1 19 0 5.50 8.50 18.50 19.00 19.00 26.00 42.00 19.26 8.12 AA 66 40 26 0 5.50 3.50 18.75 19.00 19.00 26.50 42.00 18.88 7.62 PORTUGALI MCn C93CS 18 6 10 0 70.50 70.50 14.50 18.25 19.00 19.00 19.00 16.58 3.a6 CcN1lt01f 8 4 4 0 12.50 12.50 15.75 28.50 41.25 44.50 44.50 28.50 15.19 Ali 24 10 14 0 10.50 11.50 14.50 19.00 19.00 41.25 44.50 21.35 11.02 WOn'ICn C9sCs 33 79 14 0 3.50 5.50 13.50 19.00 19.00 38.00! 57.00 20.00 12.34 ~ CGntrois 31 17 11 3 1.00 5.50 12.50 19.00 19.00 19.00' 36.00 16.15 64 AJI 64 36 25 3 1.00 5.50 13.00 19.00 19.00 34.50~ 57.00 18.18 10.43 A!1 CSSCf 49 25 24 0 3.50 6.50 14.00 19.00 19.00 34.50 57.00 19.18 10.90 C01'1tfolf 39 21 1 15 3 1.00 7.50 12.50 19.00 19.00 36.00 44.50 18.50 10.301 All 88 46 39 3 1.00 6.50 13.50 19.00 19.00 36.00 57.00 18.87 10,521 MCn CaSE3 10 4 6 0 7.50 7.50 12.00 16.50 17.75 19.00 19.00 14.88 5.06 Controls 17 7 10 I 0 5.50 5.50 7.50If 19.00 19.00 45.00 45.00 18.79 12.89 AU 27 11 ~ 16I 0 5.50 7.50 7.501 16.50 19.00 19.00 45.00 17.36 10.55 Women CisOf 23 12 11 0 11.50 11.50 14.00 19.00 19.00 20.00 36.00 18.33 6.41 COnllGlt 36 20I 16 0 1.00~ 4.25 7.00 18.501 19.001 26.00 37.00 15.63 8.95 All 59 32I 27 0 1.00 5.50 12.00 19.00 19.00 23.00 37.00 16.64 8 09 AII cases 331 16 17 0 7.50 11.50 14.00 18.50 19.00 20.001 36.00 17.47 E 14 Controls 53 27 26 0 1.00~ 5.00 7.50 19.00 19.001 29.001 45.00 16.44 9 94 AM 88 43 43 0 1.00 5.50 11.50 19.00 19.00 23.001 45.00 16.83 8 bt SPAIN Men cases E Controls AA 6 13 19 d 2 12 1~ 16 3 0 0 0 19.00 19.00 12.50 18.00 12.50 18.00 19.00 19.00 18.75 19.00 ?9.00 19.00 30.50 19.00 19.00 42.00 42.00 28.00) 30.00 30.00~ 42.00 24.75 20.00 21.79 175,: 4 E~ 6 8: WOrtM11 Cases _ 65 52 11 2 0.50 6.50 14.00 19.00 19.00 26.00 57.00 17.22 Controls i46 111 31~ 4 2.50i 11.50 17.501 19.00 19.00 30.00 51.00 19.59 1 3' ? v Afl 11 163 42 6 0.50i 10.50 16.00 19.00 19.00 28.00 57.00 18.83 A11 CDSCS 71 56 13 2 0.50 6.50 14.50 19.00 19.00 27.00 57.00 17.76 b' Controls 169 1231 32 4 2.50! 12.50 18.00 19.00 19.00 30.00~ 51.00 19.63 ~ AN 230 1791 45 6 0.50 10.50 16.50 19.00 19.00 29.501 57.00 19.04 MCn cases 20~ 16 7 0 4.00 6.50 14.00 16.50 19.00 31.00 36.00 17.09 7.83 ( COnttGf 36 20 16 0 1.50 8.00 16.75 19.00 25.25 36.50 38.00 20.28 9.55 All ~ 69 36 23 0~ 1.50 6.501 14.50 18.50 19.25 35.00 38.00 18.86~ 8.85 WCrt1Cn cases 47 25 22 0 3.00 6.50 17.00 19.00 19.00 32.00 38.00 18.98 8.16 Controls 76~ 47 29 0 50 8.00 12.00 19.00 19.00 27.00 38.00 17.41 7.51~ A8 123 72 51 1.50 8.00 14.25 19.00 19.00 27.00 38.00~ 17.961 7.721 AII Cases 70 41 29 0 3.00 6.50 14.50 19.00 19.00 31.00 38.00 18.24 7.991, - Controls 112 67 45 0 1.50 8.00 14.50 19.00 19.00 29.50 ~ 38.00 18.278.21 AJI 182 108 74 0 1.50 6.50 14.50 19.00 19.00 31.00 38.00 18.26 8.09 MCn C9sCs 3 2 1 0 '.8.50 18.50 18.50 18.50 18.50 18.50 18.50 18.50 0.00 Controls 14 10 4 0 3.50 3.50 17.50 19.00 ~ 35.00 37.00 37.00 ~ 20.85 12.27 A11 17 12 5 0 3.50 3.50 17.501 18.75 27.25 37.00 37.00 20.46 11.14 Women Cases 23 171 6 ~-0 4.50 8.50 17.50 17.50 18.50 23.00 45.00 18.38~ 8.02 COnIfWS 126I 891 ry7I 0 i.50 12.50 17.50 18.00 18.50 36.00 43.50 19.68~ 8.65 AII 149f 106 3f 0 1.50 12.50 17.50 17.50 18.50 35.00 45.00 19.47 8.53 All Cases 26 19 ' 0 4.50 8.50 17.50 17.50 18.50 23.00 45.00 18.39 7.56 COnIfOlS 140 99 d1 0[ i.50 9.50 17.50~ 18.50 19.00 36.50 43.50 19.80 9.01 AIl 166 !18 48 01 1.50 9.50 17.50 18.25 18.50 36.00 45.00 19.57 8.78 2063593342

C _C1 WS Childhood 0-18 yrs, Weighted smoking parent years MEN ONLY Lcvol ot expoaus• Casea Controls OR(,1) 95•f. Cc OR(2) 95% CI OR 3 95% C! C 4 95% C/ O 5} 9 C( Non exposmd 65 201 1.00 1.00 1.00 1.00 1.00 0<C1YfS<•14 55 188 1.03 ( 0.65- 1.64) 1.17 ( 0.71- 1.93) 0.80 { 0.44- 1.47) 1.07 ( 0.66• 1.71) 0.96 ( 0.56- 5.63) 14<C1WS<10 ii 93 0.38 ( 0.17• 0.86) 0.48 ( 0.21- 1.11)1 0.42 ( 0.14• 1.27) 0.39 ( 0.17- 0.87) 0.28 ( 0.10- 0.78) 10<C1WS 9 40 0.55 ( 0.22- i.34) 0.66 ( 0.24- 1.63) 0.94 (, 0.28- 3.15) 0.58 ( 0.23- i.46) 0.63 ( 0.22• 1.82) €xClUded/TTend 9 0.05 0.06 0.06 0.05 0•05 ( WOMEN ONLY Non exposea O<C1WS<14 i4<C1WS<10 18<C1WS €xClOded/Trlnd POPULATION BASED STUDIES 167 295 1.00 1.0o t.ao 1.00 1.00 193 394 0.78 ( 0.60- 1.02) 0.82 ( 0.62- 1.09) 0.83 ( 0.60- 1.14) 0•78 ( 0.59- 0.76 ( 0.56- 1.02) 93 239{ 0.73 ( 0,53• 1,02) 0,77 ( 0,54- i.09) 0•82 ( 0•54• 1•25) 0.75 ( 0.54- ?.OS) 0.75 ( 0.51- 1.10) 28 67 ` 0.90 ( 0.54- 1.50) 0.81 ( 0.46- 1.41) 0.74 ( 0•39- 1.41) 0.84 ( 0.50- t.42) 0.99 ( 0.52- 1.88) 8 'f 16 0.1 0 0.10 0.09 0.09 ) 0.ff Non mxpos.d 1152 326 1.00 1.00 1.00 ; 1.oa ( 1.00 0<C1WS<14 165 382 0.81 f, 0.60- 1.08) 0.85 ( 0.63- 1.15) 0.74 ( 0•53- 1.03) 0.84 ( 0.63- 1.13) 0.76 ( 0.55- 1.05) 14<C1W5<10 39 161 0.76 ( 0.49• 1.19) 0.83 ( 0.53• 1.31) 0.85 ( 0.47- 1.54) 0.81 ( 0•52- 1•28) 0.75 ( 0.42- 1.35) 18<C1WS 16 63 0.73 ( 0.39• 1.38) 0•81 ( 0.43- 1.54) 0.81 ( 0.37- 1.78) 0.71 { ~ 0.37- 1•36) 1.07 ( 0.49- 2.36) €xClOdrd/Trend 6 f8 0.10 0.09 0•07 0.10 IE 0.11 ~ HOSPITAL BASED STUDIES Non exposed 93 129 1.00 1.00 100 . 1.00 ! 1.00 0<C1WS<14 68 126 0.79 ( 0.52- 1.20) 0.89 ( 0.54- 1.45) 0 .99 ( 0.53• 1.84) 0.73 ( 0.48• 1.12) 0.78 ( 0.47- 1.29) 14<C1WS<18 64 166 0.59 ( 0.39- 0.90) 0.61 ( 0.38- 0.99) 0.74 ( 0.42- 1.33) 0.58 ( 0.38- 0.89) 0.58 ( 0.36- 0.95) 18<C1WS ~ 18 24 0.85 ( 0.42- 1.71) 0.63 ( 0.25- 9.56) 0.94 f 0.32- 2.71) 0.86 ( 0.42• 1.75) 0.72 ( 0.28- 1.83) &xCIOdld/Trendl 3 7 0.05 0.04 ~ 0.06 ~ 0.04 0.05 6<lITHOUT OCCASIONAL SMOKERS Non @xpOSmtl 181 196 14<C1W5<18 77 0<C1W5<14 i fXClOdrd/Ti-endl 6 18<C1W5 26 exposed 67 AGE <55 YEARS Non 18<C1WS l 0<C1W5<•14 j 58 14<C1W5<.10 24 15 364 1.00 1.00 1.00 1.00 1.00 424 0.90 ( 0,69• 1.18) 0.95 ( 0.71• 1.27) 0.89 ( 0.65- 1.22) 0.93 ( 0.71- 1.22) 0.82 ( 0.61- 1.17) 225 0.88 ( 0.62- 1.26) 0.96 ( 0.65- 1.41) 0.99 ( 0.63- 1.54) 0.92 ( 0.64- 1.32) 0.95 { 0.61• i.47) 74 0.89 ( 0.52• 1.52) 0.80 ( 0.44- 1.45j 0.78 ( 0.40- 1.52) 0.82 ( 0.47- 1.42) 0.84 ( 1.72) 0.41- 17 0.42 0.43 ~ 0.42 0. 42 0. 49 114 1.00 1.OO p 1.Go 1.00 ! 1.00 128 0.73 ( 0.45- 1.17) 0.95 ( 0.56- 1.60) 1.10 ( 0.58- 2.08) 0.69 ( 0.43• 1.13) 0.74 ( 0.43- 1.27) 791 0.57 ( 0.30• 1.06) 0.70 ( 0.34- 1.40) 0-95 ( 0.39- 2.28) 0.58 1 ( 0.31- 1.10) 0.41 ( 0.19- 0.87) 361 0.81 ( 0.39- 1.69) 1.13 ( 0.50• 2.57) 1.11 ( 0.41- 3-02) 0.79 ( 0.37- 1.69) 1.05 ( 0.43- 2.58) €XCludrd/Trsnd f d 4 0.>6 0.15 0.16 o f f . fs AGE 65-b4 YEARS Non exposed 0<C1WS<.14 14<C1WS<18 18<C1WS 76 17s 1,OO 1.00 t.0o 1.00 1.00 93 229 0.88 ( 0.59- t.31) 0.86 ( 0.56- 1.31) 0.78 ( 0.48- 1.26) 0.83 ( 0.56- 1.25) .5 ( 0.47- 1.18) 0 7 25~ 99 0.62 ( 0.35• 1.10) 0.60 ( 0.33- 1.09) 0.61 ( 0.29- 1,27) 0.63 ( 0.35- 1.12) 0.50 { 0.24- 1.05) 12 351 0.86 ( 0.39• 1.90) 0.72 ( 0.30• 1.74) 0.86 ( 0.32- 2.33) 0.77 ( 0.34- 1.75) 0.73 ( 0.28- 1.92) €xCluded/Trend ~ 4 13 ~ 0.21 0.23 0.15 1 0.21 0.22 AGE YEARS 85 Non exposed I 109 2os 0<C1WS<•14 97 225 14<C1WS<18 ~ 55 154 18<C1WS 10 36 Fxcludad/Trendl 4 3 HISTOLOGICALLY CONFIRMED DIAGNOSIS Non exposed 0<C1WS<14 14<C1WS<10 /8<C1WS :xcludrd/Trendf SQUAMOUS CELL CARCINOMA Non exposetl 952 496 0<C1WS<•14 35 582 14<C1WS<18 12) 332i 18<CiWS 9 1071 €xe1 uded/Trend ~ 251 SMALL CELL CARCINOMA Non exposea 28 496 0<C1WS<:14 32 582 14<CtWS<18 7 332 18<C1WS 2 107 Exc1 udi d/Trend 25 ADENOCARCINOMA Non exposed 0<01 WS<•14 14<C1W5<.10 18<C1WS E:YCludr OTHER t•00 0•84 ( 0.58- 1.20) 0.78 ( 0.51- 1.20) 0.58 ( 0.25- 1.39) 0.12 00 ! 1 1 00 1 00 . . • 0.85 ( 0.58- 1.24) 0.72 1 0.47- 1.12)~ 0.90 ( 0.62- 1.29) 0.83 ( 0.53- 1.31) 0.79 ( 0.45- 1.38) 0.78 ( 0.50- 1.21) 0.47 (, 0.18• 1.23) 0.53 ( 0.18- 1.55)~ 0.59 ( 0.25- 1.41) 0.12 0.16 0.10 1.00 1.00 1 1.00 0.82 ( 0.65- 1.04) 0.88 ( 0.69- 1.13) 0.81 ( 0.61- 1.08) 0.67 ( 0.50• 0.91) 0.72 ( 0.52• 1.00) 0.74 ( 0.50• 1.09) 0.78 ( 0.50• 1.23) 0.77 ( 0.47- 1.27) 0.78 ( 0.44- 1.38) 0.02 0.02 , 0.02 1,00 0.52 ( 0.33- 0.40 ( 0.20- 0,93 ( 0.41• 0.03 0.84) 0.55 0•80) 0.40 2.08) 0.76 E 0.03 ( 0.33- ( 0.19• ( 0-28• 0.92)1 0.86) 2.07)~ 1:00 0.55 0.55 1.06 0.02 ( ( ( 0.31- 0.23- 0.36- 0.97) 1.32) 3.10) 1.00 1.00 1.00 0•74 ( 0•43- 1.29) 0.75 ( 0.42- 1.33) 0.63 ( 0.35- 1.13) 0•74 ( 0.29- 1.92) 0.74 ( 0•28- 1.97) 0.70 ( 0•24- 2.04) 0•73 ( 0.16- 3.35) 0.74 ( 0•16• 3.43) 0.34 ( 0.04- 2.75) 0.32 0.30 0.30 1.00 1 1.00 0.83 ( 0.65- 1.05)( 0•78 ( 0.60- 1.02) 0.69 ( 0.51- 0.93)1 0.65 ( 0.46- 0.93) 0.75 ( 0.48- 1.20)~ 0.85 ( 0.49- 1.48) 0.01 0.02 1.00 0.53 ( 0.33- 0.85) 0.40 ( 0.20- 0.80) 1.00 0.53 ( 0.32- 0.90) 0.34 ( 0.14• 0.84) 0•74 ( 0.30- 1.79)~ 0.62 ( 0•18• 2.18) 0.03 0.04 1.00 0.78 ( 0.44- 1.38) 0.81 ( 0•31- 2.1,2) 0•82 ( 0.18- 3.80) 0.37 1.00 0.63 ( 0•36- 1.12) 0.68 ( 0.24- 1.91) 0.38 ( 0.05• 3.08) 0.34 124 496 1.00 1.00 i 1.00 1.00 1.00 135 582 0.91 ( 0.68- 1.22) 1.00 ( 0.73- 1.37) 0.94 ( 0.65- 1.35) 0.91 ( 0.68- 1.23) 0.86 ( 0•62- 1.19) 54 332 0.64 ( 0.43• 0.93) 0.69 ( 0.45- 1.05) 0.70 ( 0.42- 1.16) 0.64 ( 0.43• 0.95) 0.60 ( 0•38• 0.94) 15 107 0.67 ( 0.36- 1.25) 0.73 ( 0.37- 1.44)~ 0.85 ( 0.39- 1.83) 0.67 ( 0.35• 1.27) 0.84 ( 0.40- 1.77) d/Trond 5 25 0.03 0.03 . 0.03 0.02 0.03 Non oxposed 38 496 1.00 1.00 1.00 1.00 t.00 0<C1WS<.14 39 582 0.89 ( 0.55- 1.45) 0.98 ( 0.58- 1.65) 0.92 ( 0.52- 1.65) 0.87 ( 0.53- 1.43) t.02 { 0.58• 1.78) 14<C1W5<.10 27 332 1.01 (, 0.56- 1.76) 1.23 ( 0.67• 2.23) 1.19 ( 0.59• 2.41) 1.05 ( 0.60- 1.84) 1.27 ( 0.66• 2.44) 98<C1WS i 9 107 1.14 (, 0.51- 2.51) 1.13 ( 0.46- 2.76) 0.83 ( 0.27- 2.59) 1.19 ( 0.54- 2.63) 1.77 ( 0•70- 4.47) EXC1tldrdlTrrnd 2 251 0.88 i 0.90 ! 0.91 , 0.84 0.86 Non @xp4fmd 113 189 1 .00 1.00 f 1.00 1.00 1.00 0<C1WS<14 108 245 0.72 ( 0.51- 1.03)1 0.72 ( 0.51- 1.03) 0.66 ( 0.44- 0.98} 0.73 ( 0.51- 1.05) 0.71 ( 0.49- 1.03) i4<C1WS<10 26 95 0.49 ( 0.28- 0.87)1 0.49 ( 0.28- 0.67) 0.45 ( 0.2?• 0.98) 0.50 ( 0.28• 0.89) 0.49 ( 0.26. 0.93) 18<C1WS S 41 0.31 ( 0.11- 0.85)) 0.31 ( 0.11- 0.85) 0.32 ( 0.10• 1.03) 0.25 ( 0.08- 0.76) 0.30 ( 0.10- 0.92) €XCludrd/Trend 4 5 0•00 ~ 0.00 0.00 1 0.00 0.00 >75x OF LIFESPAN IN URBAN AREA Non exposed 70 215 1,00 1.00 1.00 1.00 1.00 0<C1WS<14 104) 239 1.35 ( 0.91• 2.00) 7.35 ( 0.91• 2.00) 1.24 ( 0.79- 1.96) 1.33 ( 0.89- 7.96) 1.28 ( 0.62- 2.01) 94<C1WS<18 53 191 0.95 ( 0.60- 1.51) 0.95 ( 0.60- 1.51) 1.06 ( 0.62- 1.82) 0.98 ( 0.62• 1.56) 0.85 ( 0.49- 1,47) 18<C1WS 13 51 1.00 ( 0.48• 2•06) 1.00 ( 0.48- 2.06) 1.04 { ~ 0.43- 2.46) 0.92 ( 0.43- 1.95) 1.44 ( 0.58• 3.58) €xaludrd/Trend 4 15 0.96 0.96 ~ 0.95 0.87 0.94 11) Mode) indudo sex, canlor, sex•eenter snd age (2) Medet Irtciuda sex, center, sex'canter, age antl proportion of residential type in the !ast 35 yra (REUP) (3) Modal Includo sex, eonter, sexbenter, age, proportion of res~ential type wi the last 35 yrs (REUP) and educational level (EDUC) (4) MOde! rclctuds sex, C6nt@r, aax'canter, age antl duratron of exposure to iist A agents (OCLAY) (5) Modei Include sex, centor, sex'Canter, age and frequency consumption of vegetables (VEGE) ils_ - 2`1 63.J 7 +D .] G 4 ;3i~tL et'mate~ _ i^F'IliF, nri n_•1 R

c1 US Childhood 0-18 yrs, Smoking parent years ~ Totsl Exoosed Unexoosed Exduded Min P10 ~ 01 Median 03 P90 i Max ~ Mean Std I Men CiSRt 157 76 80 1 0.50 6.50 11.00 14.50 19.00 25.00 42.00 15.20 7.561 CCntrol3 680 335 236 9 1.00 6.50 11.00 19.00 19.00 35.00 65.50I 18.04 10.691 , A11 737 411 316 10 0.50 6.50 11.00 18.00 19.00 33.00 65.50 17.52 10.231 WOn'1Cn CaSCa D 0 0 0 ~ € Controls 0 0 0 0~ All 0 0 0 0 € ii AN C85CS 157 76 80 1 0.50 6.50 11.00 ' 14.50 19.00 25.00 42.00 15.20 7.56! Controls 580 335 236 9 1.00 6.50~ 11,00@ ( 19.00 19.00 35.00 65.50 18.04 10.69) - Alt 737 411 316 10 0.50 6.50~ 91.00t 18.00 19.00 33.00 65.50 17.52 10.23 Men Casfs 0 0 0 Controls 0 0 0 0 - ~ ~ Atl 0 0 0 Won1M Case3 _ 550 344 198 8 0.50 6.50 11.00 18.50 19.00 28.50 68.00 17.54 10.09~ ConttolS 1076 716 344 16 1.00 6.50 11.00 18.50 19.00 ~ 31.00 60.00 17.75 9.451 AII 1626 1060 642 24 0.501 6.50 11.00 18.50 19.00 30.25 66.00 17.68 9.66 A~ CaSez 550 344 198 8 0.50 6.50 11.00 18.50 19.00 28.50 68.00 17.54 10.091 Controls 1076 716 344 16 1.00 6.50 11.00 ~ 18.50 19.00 31.00 60.00 17.75 9.45 A}1 1826 1060 542 24 0.50 6.50 11.00 18.50~ 19.00 30.25 68.00 17.68 9.661 ,'YLf4/1 Men V~ u~WGY Cases V,vY~.., 91 55 35 1 0.50 3.50 11.00 11.00 19.00 25.50 36.00 14.11 7.69 Controls 444 266 169 9 1.00 5.50 11.00 17.50 19.00~ 33.00 65.50 17.23 10.721 A11 535 321 204 10 0.50 5.50 11 .00 t 15.50~ 19.00f 29.00 65.50 16.69 10.321 Wo771C71 CiSCf 287 165 117 5 1.00 5.50 10.50 11.00 19.00 25.00 62.00 14.97 9.58 Conttolz ~ 506 340 157 9 1.00 5.50 11.00~ 13.75 19.00 30.75~ 60.00 16.64 10.571, AN ( 793 S05 274 14 1.00 5.50 10.50 12.00 19.00 28.50 62.00 16.10 10.27i All Cases 378 220 152 6 0.50 5.50 10.50 11.00 19.00 25.25 62.00 14.76 9.13 Controls ~ 950 606 326 18 1.00 5.50 11.00 15.50 19.00 31,001 65.50 16.90 10.63 All 1328 826 478 24 0.50 5.50 11.00 14.50 19.00 29.00 65.50 16.33 90.29 HO5PITAL BAS€0 STUDIES Men cases 47 18 29 0 7.50 10.50 14.50 18.25 19.00 23.00 42.00 17.97 7.111 Controls 73 45! 28 0 5.50~ 11.50 17.50 19.00 9.00 1 38.00 45.00 20.41 9.081 A!I 120 83 57 0 5.50 11.50 16.50 19.00 19.00 37.00 45.00 19.71 8.581 WOmCn Cascf , 199 732 64 3 0.50 8.50 73.75 19.00 19.00 26.00 57.00 17.84 8.77 Controls 379 271 101 7 1.00 9.00 14.50 19.00 19.00 27.00 51.00 18.24 7.61 All 578 403 165 10 0.50 8.50 14.50 19.00 19.00 27.00 57.00 18.11 7.771 All Cases 246 150 93 3 0.50 8.50 14.50/ 19.00 '.9.00 26.00 57,00 17.86 7.971 Controls 452 316 1291 ' 1.00 9.00 15.25 19.00 19.00 29.50 51.00 18.55 7.86 All 698 466 1 222 10 0.50 9.00. 14.50 19.00 19.00 50 57.00 78.33 7.90 WITHOUT OCCASIONAL SMOKERS MCn Cases 112 55 56 1 0.50 3.50 11.00 13.50 19.00! 25.50 54.75 8.171 42.00 Controls 406 228 173 5~ 1.00 6.00 11.00 17.75 19.0oI 35.00 ~ 65.50 17.52 10.631, I Ali 518 283 229 6 0.50 5.50 11.00 17.50 19.00 33.00~ 65.50 16.98 10.241 WomQn CaSCf 430 275 150 5 0.50 7.50 11.00 18.50 19.00 31.00 68.00 17.78' 10.531 Controls 810 525 273 12 ?.00 6.50 11.00 18.50 19.00I 31.00 57.50~ 17.51 9.62 t240 All 800 423 17 0.50 6.50 11,00 18.50 19.00i 31.00 68.00~ 17.61 9.94 Ap CdSes 542 330 206 6 0.50 6.50 11.00 17.50 19.00 28.25 10.231 68.00} 17.28 Controls 1216 753 446 17 1.00 6.50 11.00 18.50 19.00 32.00 ~ "7.51 9.931, 65.504 AH t758 1083 652 1 23 0.50 6.50 11.00 18.50 19.001 31.00 i 68.00 17.44 90.02 AGE e55 YEARS h1M CiSQf 57 31 ~ 172 100 Controls All 229 931 WO777 Cn ("ilSCf 138 02 Conllols 254~ 159 Alt 392 241 26 0 1.50 9.00 77.00 74.50 22.00 26.50 36.00 15.94~ 8.21 ?2! 0 1.00 8.00 11.00 19.00~ 23.50 38.U0 65.SOI 19.91 11.95 98I 0 1.00 3.50 11.00 98.50 22.50 37.00 55.50 18.97 91.281 55 1 O.SD 0 11.00 19.00 79.001 37.00 62.00 19.49 10.511 91 4 1.00 8.00 11.00 19.00 19.001 32.50 60.00 98.03 9.64~ i46 5 0.50 8.50 11.00 19.00 19.00 32.50 62.00 78.52 10.03 All C950f 195 t13 81 1 0.50 9.00 11.00 19.00 19.00 31.50 62.00 18.51 10.031 ConUols 426 259 163 4 1.00 8.00 11.00 19.00~ 19.50 37.00 65.50 18.75 10.721 All 621 872 244 5 0.50 8.50 11.00 19.00~ 19.25 36.00 65.50 18.68 10.501 AGE 55 64 YERRS 1 3 00 50 6 50 8 11 00 18.50 19.00! 26.50 13.281 6.16/ MCn C-0+Cf C If01 on f 52 216 25 18 26 92 6 . 1.00 . . 5.50 11.00 . 16.75 19.00 27.00! 65.50 16.39 10.28l 1 268 143 118 7 00 1 50 11.00 5 15.50 19.00 25.00~ 65.50 15.85 9.751 women Al Cascz ?76 115 58 3 . 1.00 . 5.501 17.00 17.50 19.00 29.00 68.001 17.16 10.99 ~ I CatUOtf ~1 359 535 250 365 102 160 7 10 1.00 1.00~ 4.75 ':1.00 5.00 /1.00 18.50 18.00 19.00 19.00 30.75 46.50 30.50 68.00 17.01 I 17.06 9.18 9.77 All Cases 228 140 84 4 1.00 5.50 11.00 15.501 19.00 27.50 68.00 16.47 10.38 Controls 575 368 94 13 '..00 5.00 11.00 17.50 ~ 19.00 30.50 65.50 16.81 ~ 1 9.54 ! All 803 S08 278 17 1.00 5.50 11.00 ':7.50 19.00 29.50 68.00 16.72 1 9.77 AG€ 65+ Y€ARS 0 7 50 50 18 00 12 19 00 19 25 00 42 16.48 ' 8.02I Men Cases 48 20 28 0. .50 . . . . . . Controls 192 ~ 117 72 3 1.00 6.00 11.00 19.00 19.00 33.00 57.00 18.11 9.73 AIl 240 137 100 3 0.50 6.00 11.50 19.00 19.00 33.00 57.00, 17.87 9.49; Women CssQf 236 147 85 4 1.00 6.50 11.00 18.50 19.00 26.00 57.001 16.76 8.99 Controls 463 307 151 5 2.50 8.50 11.00 18.50 19.00 31.00 57.50 18.21 9.45 AI1 699 454 236 9 `:.00 7.50 11.00 18.50~ 19.00 - 29.50 57.50 17.74 9.32', An Ci5Q9 I 284 157 113 4 0.50 6.50 11.00 18.50 19.00 26.00 57.00 16.72 8.86; Controls A~I 655 9391 424 591 223 336 8 12 1.00 0.50 8.50 7.50 11.00~ 19.00 11.00 18.50 19.00 19.00 32_00 ~ 29.50 57.50 57.50 18.19 17.77 9.52! __ 9.35

t' Vur Childhood 0-18 yrs, Weighted duration (years) A!oN arir.Y LeVet of expOSUfD CiSeS i Controls 1 OR(11 95X CI OR(21 95X Cl OR(3) 95% CI 1 ORf4 95% CI I OR(5) 95% Ct Non eXpoSOC 65 201 1.00 1.00 1.00 1.00 1•00 0<C1VY0<1D ~ 58 192 1.03 ( 0.65- 1.63)1 1.16 ( 0.71• 5.90) 0.84 ( 0.46- 1.53) 1.06 ( O.fi7- 1.69) 92 ( 0.54- ~ 0 . 1,56) 1fl<CiWD<26 12 95 0.37 ( 0.17- 0.81) I 0.41 ( 0,17- t.00) 0.42 ( 0.15- 1.17) 0.35 ( 0.16- 0.79) 0.37 ( 0.14- 0.96) 28<C1Yf0 ~ 5 34 0.49 ( 0.17- 1.44) 0.64 ( 0.22- 1.92) 0.73 { 0.19- 2.75) 0.57 ( 0.19- 1.67) / 0.53 ( 0.15- 1.84) k rcluded/rr.nd 1 9 0.05 111 0.04 ( 0.05 0.04 P { 0.05 WOMEN ONLY exposed Non 187 295 1.00 ' 1.00 1.00 1.00 1.00 0<CiYiD<1 9 216 1 446 0,78 ( 0.60- 1.01) 0.82 ( 0.62- 1 .08) 0.84 ( 0.61• 1.14) 0.78 ( 0.60• 1.01) 0.77 ( 0.57- 1.03) 1fl<C1Y(0<28 78I 164 0.80 ( 0.57- 1.13) 0.84 ( 0.58- 1.20) 0.89 ( 0.58• 1.36) 0.81 ( 0.57- 1.15) 0.82 ( ~ 0.55- 1,24 ) 26tC1N9 20 i 70 0.63 ( 0.36- 1.10) 0.57 ( ~ 0.31- 1.04) 0.50 ( 0.24• 1.02) 0.61 ( 0.35- i.08) 0.62 ( 0.31- 1.21) tt Exc1 udod/Tr.nd 8 `{ 16 0.04 0.05 0.03 0.04 0.05 ( POPULA11ON ®ASED STUDIES Non exposstl 152 326 1.00 1.00 1.00 1.00 1.00 0<C1W0<19 166 389 0.80 ( 0.80- 1.07) 0.85 { 0.63- 1.14) 0.75 ( 0.53- 1.04) 0.84 ( 0.62- 1.12) 0.76 ( 0.55- 1.04) 19<C1W0<26 41 163 0.76 ( 0.49- f.18) 0.84 ( 0.54- 1.31) 0.81 ( 0.47• 1•39) 0.81 ( 0.52• 1.25) 0.79 ( 0.45- 1.38) as<ciwo 13 54 0.77 ( 0.39- 1,52) 0.84 ( 0.42- 1.67) 0.73 { 0.30- 1.74) 0.74 ( 0.36- 1.50) 1.10 ( 0.44- 2.74) ErC1 udad/TronrJ 6 18 0.14 0.13 0.09 0.14 0.15 HOSPITAL BASED STUDIES Non oxposed 93 12s i.0o 1.ao ; 1.ao 1.00 1.00 O<C11W<19 91 176 0.77 f, 0.52- 1.14) 0.82 ( 0.52- 1.29) 0.90 ( 0.50- 1.60) 0.73 ( 0.49- 1.09) 0.72 ( 0.45- 1.16) 19<C1Yt0 <26 48 109 0.65 ( 0,41• 1,03J 0.65 ( 0,39- 1.11) 0.83 ( 0.44- 1,55) 0.61 ( 0.39- 0.98) 0.66 ( 0,38- 1•12) 28<C1WD 11 31 0.48 ( 0.22- 1.03) 0.40 ( 0.16- 1.00) 0.56 ( 0.20- 1.61) 0.50 ( 0.23- 1.08) 0.41 ( 0•16- 1.04) c'xcludod/TYrond 3 7 0.02 0.02 0.03 0.01 0.02 WITHOUT OCCASIONAL SMOK Non QxpOSeC 0<C1WD<19 19<CiWD<26 26<C1Yf0 Excluded/Trend RS 181 384 100 • 1.00 100 . 1.00 1.00 215 461 .92 ( 0.71- 1.19) 0 0.97 (, 0.73- 1.29) 0 .93 ( 0.68- 1.26) 0.95 ( 0.73- 1.23) 0.84 { 0.63- 1.13) 65 197 0.85 ( 0.58- 1.22) 0.86 ( 0.58. 1.30) 0.86 ( 0.55- 1,36) 0.87 ( 0.60- 1.26) 0.90 ( 0.57- 1.42) 19 65 0.83 ( 0.46- 1.49) 0.85 ( 0.46- 1.58) 0.73 ( 0.37- 1.48) 0.81 ( 0.45- 1.48) 0.79 ( 0.38- 1.66) 6 17 0.33 0.33 0.30 0.33 i 0.39 AGE <85 YEARS Non axposed 67 11a 1.00 1.0o 1.00 1.00 1•00 0<CiM'D<19 65 137 0.76 ( 0.48- 1.21) 0.95 ( 0.57• 1.59) 1.11 ( 0.59- 2.09)1 0.73 ( 0.45- 1.17) 0,75 ( 0.44• 1.29) ~ ifl<C1WD<26 I 24 73 0,62 ( 0.34- f.15) 1 0.85 ( 0.43• 1.69) 1.10 ( 0.48• 2.50) 0.63 ( , 0.34• 1.18) 0.50 ( 0.24- 1.05) a8<C1VW Ii 8 331 0.50 ( 0.20- 1.24) 0.67 ( 0.25- 1.83) 0.57 ( ~ 0.15- 2.10) 0.45 ( 0.17- 1.17) 0.56 ( 0.19- 1.65) Exc1 udid/Trend ~ t 4 0.05 1 0.09 0.05 ` 0.04 0,05 AGE 55-64 YEARS Non txposea 76 176 t.oo 1.00 1.00 1.00 1,00 0<C1W0<19 97 236 0.87 ( 0.59- 1.30) 0.86 ( 0.56. 1.31) 0.78 ( 0.48- 1.26) 0.83 ( 0.55- 1.24) 0.76 ( 0.48- 1.19) 19<C1WD<•26 25 91i€ 0.68 ( 0.39- 1.21) 0.63 ( 0.34- i.14) 0.69 ( 0.34. 1.40) 0.68 ( 0.39- 1.21) 0.59 ( 0.29• 1.22) 26<C1Yr~ 8 54, 0,65 ( 0.27. 1.54) 0.58 ( 0,23. 1.44) 0.63 ( 0.23- 1•75) 0.63 { 0.26- 1.52) 0.39 ( 0.12- 1.23) zxcludtd/Trsnd 4 >3I 0.16 0.17 ? 0.11 ~ 0.16 0118 AGE 65t YEARS Non exposed 0<C1W0<•19 19<C1WD<26 26<C1YfD Exc1 uded/Trend 109 112 41 9 4 HISTOLOGICALLY CONFIRMED DIAGNOSI Non exposed 0<C11Y0<19 19<CiPfD<26 26<C1WD Excluded/Trend SCUAMOUS CELL CARCINOMA Non axposea 0<C1W17<19 19<C1YrD<26 26<C1WD 5xcluded/Trend 52 39 12 5 . SMALL CELL CARCINOMA Non exposea 0<C1WD<19 19<CiWD<26 26<C1PN Excludtd/Trend ADENOCARCINOMA Non exposed O<C1YiD<.19 19<C1HD<S26 28<C11Y0 Ekcludad/Trand 28 32 2 206 263 115 37 8 96 638 279 104 25 496 638 279 104 25 496 638 279 104 25 1.00 1.00 0.81 ( 0.57- 1,15) 0.82 ( 0.57- 1.19) 0.83 ( 0.51. 1.33) 0.89 (, 0.54. 1.47) 0.61 ( 0.27• 1.39) 0.51 (. 0.21• 1.26) 0.16 0.16 1.00 1.00 0,82 ( 0.65• 1,03) 0.88 ( 0.69- 1.12) 0.71 ( 0.52- 0.97) 0.76 ( 0,55• 1.07) 0.59 ( 0.36- 0.96) 0.59 ( 0.34- 1.00) 0.01 0.01 1.00 1.00 0.53 ( 0.33• 0.84) 0.54 ( 0.33- 0.88) 0.50 ( 0.25- 0.99) 0.48 ( 0.22- l.os) 0.59 ( 0.22- 1.58) 0.57 ( 0.19- 1.69) 0.02 0.02 1.00 1.00 0.72 ( 0.42- 1.26) 0.73 ( 0.41- 1.29) 0.80 ( 0.32. 2.02) 0.85 ( 0.33. 2.17) 0.83 ( 0.18- 3.86) 0.81 ( 0.17- 3.78) 0.43 ~ 0.40 1.00 1•00 1.00 0.72 ( 0.47- 1.11) 0.87 ( 0.61• 1.23) 0.78 ( 0.53- 1.15) 0.82 ( 0.45- 9,50) 0.80 ( 0.49- 1.31) 1.04 ( 0.60• 1.80) 0.48 ( 0.17- 1•39) 0.64 ( 0.28- 1.46) 0.85 ( 0.33- 2.20) 0.19 ) 0.13 0.18 ~ 1•00 1,00 1-00 0.56 ( 0.32- 0.98) 0.52 ( 0.32• 0.82) 0.52 ( 0.31- 0.87) 0.71 ( 0.30- 1.67) 0.50 ( 0.25- 0.99) 0.42 ( 0.17- 1.06)I 0.53 ( 0.02 0.15- 1.88) ) 0.51 ( 0.02 0.17- 1.51) 1 0.38 ( 0.03 0.09- 1.68 ii111) 1.00 1.00 1.00 t 0.61 ( 0.34- 1.11) 0.76 ( 0.43- 1.34) 0.62 ( 0.35- 1.10) 0.76 ( 0.27- 2.12) 0.89 ( 0.35- 2.26) 0.74 ( 0.27- 1.99) 0.37 { 0.05• 2.97) 0.97 ( 0.21- 4.56) 0.43 ( 0.05- 3.48) ~ 0.39 0.50 0.45 t24 a96 1.00 1.00 1.00 1.00 1.00 t 148 638 0.88 { 0.66171 j 0.97 ( 0.71- 1.32) 0.91 ( 0.63- 1.31) 0.89 ( 0.67•i.19)1 0.83 ( 0.60- 1.14)~ 44 279 0.67 ( 0.45) 0.74 ( 0.47- 1.15) 0.82 ( 0.49- 5.37) 0.65 ( 0.43- 0.99)'E 0.68 ( 0•42- 1.09)' j 12 104 0.57 ( 0.29- 1,11) 0.59 ( 0.29- 1.22) 0.59 { 0.25- 1.41) 0.59 ( 0.30- 1.16)1 0.62 ( 0.28- 1.35)~ ~ 5 25 0.03 t 0.03 0.03 0.02 Illt 0.03 oTHER Non exposed 38 496 1.00 E 1.00 1.00 1•00 1.00 0<CSVtD<+19 47 638 0.98 ( 9.62• 1.57) 1.09 ( 0.66- 1.80) 1.06 ( 0.61- 1•86) 0.97 ( 0•61- 1.56) 1.12 ( 0.66- 1.92) 19<C1WC<.26 23 279 1.01 ( 0.57• 1.79) 1.18 ( 0.64. 2.18) 0.90 ( 0.43- 1.90) 1.03 ( 0.58• 1.83) 1.32 ( 0.67- 2.58) 28<C1Yr1) 5 104 0.63 (, 0.24• 1.70) 0.61 ( 0.20- 5.84)~ 0.61 ( 0.17- 2.17) 0.68 ( 0.25- 1.83) 0.87 ( 0.28- 2.71) cxcludad/Trtnd 2~ 25 0.52 0.51 1 0.49 ( 0.56 0.54 >75% OF LIFESPAN IN RURAL AREA OR INTERMEDIATE CITIES Non oxposed 113 189) 1.00 1.00 1.00 1.00 1.00 0<CiWDs1D 110 258 0.71 ( 0,50- 1.00) 0.71 ( 0.50- 1.00) 0.63 ( 0.42- 0.94) 0.71 ( 0.50- 1.01) 0.69 ( 0.48- 1.00) 19<C1WD<.2B 26 ~ 84 0.56 ( 0.33• 0.97) 0.56 ( 0.33• 0.97) 0.65 ( 0.34- 1.26 ) 0.58 f, 0.33- 1.01) 0.61 { 0.34- 1•10) 26<C1Yi0 3 39 0.20 t 0.06. 0.68) 0.20 ( 0.06• 0.68) 0.10 ( 0.01• 0.76) 0.20 { 0.06- 0.70) 0.16 ( ~ 0.04- 0.73) Exclud.d/Trand! 41 5 0.00 ) 0.00 0,00 ~ 0.00 1 0.00 s7544 OF LIFESPAN IN URBAN AREA HOn exposed 70 215 1.OO 1,00 1.00 1.00 1.00 0<C1YN<19 118 273 1.28 ( 0.87- 1.88) 1.28 ( 0.87- 1.88) 1.23 ( 0.79- 1.93) 1.26 ( 0.85- 1.86) 1.20 ( 0.78- f.86) 19tCiWD<26 40 154 1.04 ( 0.64- 1.69) 1.04 ( 0.64• 1.69) 1.05 ( 0.59- 1.86) 1.07 ( 0.65• 1.76) 1.01 ( 0.55- 1.85) 28<C1Y1D 12 54I 0.86 ( 0.41- 1.79) I 0.86 ( 0.41- 1.79) 1.02 ( 0.46- 2.27) 0.77 ( 0.36- 1.66) 0.97 ( 0.40- 2.37) 5XCluded/Trtnd 4 151f 0.86 €iii 0,86 0•86 ~ 0. T6_ 0. 86 (1) Model inc}ude sox, canter, sox•conter and age i2) Model mckx~a sex, contor, sex'canter, aga and proportion of residential type in the last 35 yrs (REUP) (3) Model wtcklde sex, conter, sox'eenter, age, proportion of residential type in ttte last 35 yrs (REUP) and educationat level (EDUC) (4) Model "rndude sex, canter, sex•Center, age and duration of exposure to list A agents (OCLAY) (5) Model inafude sex, oenter, sex`canter, age and frequency wnsumption of vegetables (VEGE) ~ _~- 2063593330 Risk estimates - Childhood 0-18 years

D _v 1GLII Spouse, Cumulative exposure (packs/day x years) MEN ONLY Lv.l of osuro Cases Controls NE., S1CU"13 137 504 13<S1CU<23 1 5 I Excludtd/Trtndl 31 Y.`OMEN ONLY ORH) 95% Cl 1.00 1.75 ( 0.17•18.32) OR(2) 95H. CI ( OR(3) 95% Cl 1.00 1.00 1.75 ( 0.16-18.62)1 0.00 ( 0.00-99.99) i 221 0.64 1 0.67 1 0.65 9R(4) 95% Cl ) OR(5) 95% Cl ) 1.00 ( 1.00 I 1.82 ( 0.17-19.14) 1 4.56 ( 0.22•93.44) 1 0.62 1 0.64 NE., .i10U<13 348 685 1.00 1.00 1.00 1.Op 1.00 13<S1CU<23 ~ 35 78 0.86 ( 0.56- 1.34) 0.75 ( 0.46- 1.22) 0.48 ( 0.27- 0.88) 0.91 ( 0.58- 1.40) 0.65 ( 0.39- 1.09) a9<S1CU 42 55 1.81 ( 1.04- 2.50) 1.51 ( 0.95• 2.40) 1.45 ( 0.87- 2.41) 1.64 1, 1.05- 2.54) 1.50 ( 0.90- 2.52) ° 1Ud d d xe a /Tran 84 193 0. 1 1 ~ t 0.10 ~ o. 10 ~ 0.11 ) 0.12 POPULATION BASED STUDIES NE., S1CU<.13 307 13<S1CU<23 16 23<SiCU 21 853 1.00 1.00 1.00 1.00 1.00 37 0.85 ( 0.45- 1.61)1 0.82 ( 0.42- 1.57) 0.62 ( 0.28• 1.36) 0.86 ( 0.46• 1.64) 0.90 ( 0.44- 1.84) 29 1.49 ( 0.80- 2.75)~ 1.53 ( 0.83• 2.85) 1.30 ( 0.66- 2.54) 1.51 ( 0.81- 2.79) 1.57 ( 0.76• 3.27 ) E €.YCludad/Trsnd d4 3f 0.36 1 0.38 0.33 ~ 0.36 0.37 ~ HOSPITAL BASED STUDIES NE., S10U<e13 178 336 13<S1CU<23 20 46 23<S1CU 21 26 I 1.00 , 1.00 1.00 1.00 1.00 0.94 ( 0.52• 1.68)0.75 ( 0.38- 1.49) 0.38 ( 0.15- 0.97) 1.00 ( 0.55- 1.80) 0.55 ( 0.26- 5.13} 1.82 ( 0.96- 3.43) 1.50 ( 0.75- 3.02) 1.86 ( 0.85- 4.08) 1.85 ( 0.98- 3.49) 1.54 { 0.74- 3.21) Excluoed/Trand 271 44 0.14 0.14 0.12 1 0.13 0.13 OCCASIONAL SMOKERS WITHOUT NE., S1GU<.13 361 856 1.00 1.00 1.00 1.00 1 1.00 13<SiCU<23 28 67 . 0.84 ( 0.52- 1.37) 0.74 ( 0.43- 1.27) 0.57 ( 0.30- 1.06)1 0.89 ( 0.54- 1.45) i 0.58 ( 0.33- 1.05) 23<S1CU 30 47 1.30 ( 0.78- 2.15) 1.16 ( 0.68- 1.99) 1.28 ( 0.72- 2.27) 1.32 ( 0.80- 2.19)~ 1.07 ( 0.58- 1.96) €xcluded/Trfnd 67~ 134~ 0.54 ( 0.54 ~ 0.53 ~ 0.53 [ 0.56 AGE < YEARS 55 NE., S1CU<.13 1 3<S1CU<.23 23<SiCU 549 320 1.00 1.00 1.00 1.00 1.00 2 18 0.17 ( 0.04- 0.77) 0.11 ( 0.01- 0.84) 0.00 ( 0.00-99.99) 0.18 ( 0.04- 0.80) 0.11 ( 0.01- 0.90) 5 8 1.64 ( 0.46- 5.84) 1.22 ( 0.27- 5.45) 1.13 ( 0.25- 5.05) 1.73 ( 0.48- 6.23) 1.25 ( 0.19- 8.38) €xcludtd/Trandi 9 15 0.46 0.44 0.42 ~ 0.46 1 0.46 AGE 55-W YEARS NE., 51CU<13 153 429 1.00 1.00 1.00 1.00 1.00 13<S1CUw23 14 26 1•28 ( 0•62• Z 67) 1.00 ( 0.45- 2.20) 0.72 ( 0.27- 1.89) 1.28 ( 0.61- 2.66) 1.12 ( 0.48- 2.63) 23<S1CU 15 14 2.97 ( 1.31- 6.75) 2.56 ( 1.08- 6.07) 2.70 ( 1.01- 7.20) 2.91 ( 1.28• 6.60) 3.06 ( 1.19- 7.84) ~ €.rcludidiTrtnd I Q ~ 8!! 83I 0.01 ~ 0.01 0.01 0.01 0.01 AGE 65+ YEARS NE., S1CUe.13 13<SiCU<23 23<S1CU 183 440 1.00 1.00 1.00 1.00 1.00 20 39 1.03 ( 0.57- 1.88) 0.94 { 0.49- 1.82) 0.60 ( 0.26- 1.37) 1.10 ( 0.60- 2.02) 0.70 ( 0.35- 1.40 ) 22 33 1.38 (- 0.76• 2.52) 1.47 ( 0.80- 2.?1) 1.53 ( 0.77- 3.04) 1.41 ( 0.77- 2.56) 1.23 ( 0.63- 2.39) fXClutfBd/Trtnd SO! 117 0.33 0.33 0.24 0.33 0.35 HISTOLOGICALLY CONFIRMED DIAGNOSIS t1E., SiCU<.13 471 1189 1.00 '3<81CU<23 35 33~ 0.88 1 0.57- 1.36) 23<S1CU 40 55 1.57 ( 1.01- 2.46) 1 ( €xcludad/Trandl 31 2151 0.13 1.00 1 1.00 1.00 1.00 0.79 ( 0.49- 1.26 ) 0.49 ( 0.27• 0.88) 0.92 ( 0.59- 7.42) 0.70 ( 0.42- 1.15) 1.47 ( 0.92• 2.35) 1.48 ( 0.89- 2.45) 1.59 ( 1.02• 2.49) 1.54 ( 0.92- 2.58)~ 0. 13 0.12 ~ 0.13 PPP 0.74 ( SQUAMOUS CELL CARCINOMA NE., S1GU<.13 ?9 i ',1891 1.00 1.00 1.00 1.00 1.00 13<SiCU<23 l ] 7 83~ 1.05 ( 0.44- 2.46) 0.71 ( 0.24- 2.07) 0.18 ( 0.02- 1 .38) 1.07 ( 0.45- 2.53) 0.48 ( 0.14- 1.66)1 ! 23<81CU 5 551 1.19 ( 0.44• 3.22) 0.74 ( 0.22- 2.53)~ 0.82 ( 0.24- 2.85) 1.19 ( 0.44- 3.23) 0.57 ( 0.13- 2.53) 1 1 1 Excluded/Trand 18 215 0.73 0.72 F 0.65 i 0.72 0.74 SMALL CELL CARCINOMA NE., S1CU<13 13<51CU<23 n 3<SiCU - 60 t189 1.00 ' 1.00 1.00 1.00 t.00 7 ~ 831 2.01 ( 0.80- 5.02) 1.75 ( 0.66- 4.62) ~ 2.08 ( 0.76- 5.70) 2.01 ( 0.80- 5.05) 1.75 ( 0.65- 4.70) . 1 55 0.31 ( 0.04• 2.38) 0.30 ( 0.04- 2.35) 0.39 ( 0.05- 3.09) 0.30 ( 0.04- 2_33) 0.33 ( 0.04- 2.60) Excludtd/Trand! 12 .'.15~ 0.77 ~ 0.75 0.81 0.77 0.76 ADENOCARCINOMA NE., 81CU<.13 257 1189 1.00 1.00 1.00 1.00 1.00 13<S1CU<23 15 0.66 ( 0.37- 1.23) 831 0.60 ( 0.31- 1.15) 0.32 ( 0.13- 0.79) 0.71 ( 0.39- 1.28) 0.53 ( 0.27• 1.05) 23<S1CU 28 t 55' 2.02 ( 1.22- 3.35) 1.96 ( 1.15- 3.33) ~ 1.96 ( 1.10. 3.48) 2.06 ( 1.24- 3.42) 1.94 ( 1.09• 3.47 ) EXCI UdOd/Trtnd l 33 2151 0.05 0.05 ~ 0.05 i 0.05 1 0.06 ~ OTHER HE., S1CU<73 13<$iCU<23 23<S1CU 86 1189 1.00 1.00 1.00 7.00 1.00 6 "03 0.76 ( 0.31- 1.86) 0.85 ( 0.35- 2 11) 0.44 ( 0.13- 5.50) 0.80 ( 0.32- 1.95) 0.75 ( 0.28- 2.02) 6~ 55 E 1.33 ( 0.53- 3,34) 5.36 ( 0.54. 3.41) 1.24 ( 0.45• ".42) 1.36 ( 0.5:- 3.42) 1.92 ( G.73• 5.04) Excludod/Trano' 18~ 215 0.82 0.84 0.85 0.80 0.82 g75'AE OF LIFESPAN IN RURAL AREA OR INTERMEDIATE CITIES NE., S1CUes13 182 406 1.00 - 1.00 1.00 1.00 1.00 13<SiCU<23 ~ 17 24 1.43 ( 0.70- 2.90) 1.43 ( 0.70- 2.90) 0.89 ( 0.35- 2.30) 1.48 ( 0.72- 3.02) 1.17 ( 0.56- 2.46) ~ 23<61CU 16 14 ~ 2.17 ( 0.97• 4.83) 2.17 ( 0.97• 4.83) 2.59 ( 1.04- 6.40) 2.25 ( 1.01- 5.02) 1.75 ( 0.74- 4.11) 11 €xcludtd/Trfndl 41~ '31 0.04 ~ 0,04 ~ 0.02 , 0.04 ~ 0.04 1 a75% OF LIFESPAN IN URBAN AREA NE., 810U<t3 1861 562 13<S1CU<23 10 48 23<S1CU 19 34 €xcludod/Trtnd 29~ 67 t.0o 1.00 1 1.00 t.oo 1.00 0.53 ( 0.25- 1.11) 0.53 1 0.25- 1.11) 0.40 ( 0.17- 0.95) 0.58 !, 0.27. 1.22) 0.49 { 0.21- 1.14) 1.42 ( 0.76• 2.66) 1.42 ( 0.76• 2.66) 1.24 ( 0.61- 2 50) 1.43 ( 0.76- 2.69) 1.66 ( 0.80- 3.47) 0.73 i 0.73 i 0.73 0.71 t 0.75 (1) Model ktdude sex, center, sex'center and age (2) Model indUde sox, center, sex'center, a9e and proportion of residential type in the last 35 yrs (REUP) (3) Model Indudo sex, center, sex'center, age• proporUon of residentiat type in the last 35 yrs (REUP) and educational level (EDUC) (4) Modet indude sex, center, sex'center, age and duration of exposure to list A agents (OCLAY) (5) MOaCt IAduCa sex, cent", sex'CCntCr, age and frequency consumption of ve9etables (VEGE) 2063593373 Risk estimates - Spouse

C - s1CU Spouse, Cumulative exposure (packs/day x years) tu-ti-cF.trMt=s Lev.t ot axposun Non exposmd 0<S1CU<13 13<31CU<23 23<S1CU ALL CENTERS WYrH EDUCATIONAL LEVEL AND TYPE OF RESIDENCE Non exposea 0<S101.1<13 13<S1CU<23 23<S1CU Ercludad/Trend! 143 ALL CENTERS WITH DIETARY DATA Non exposmd 0<S1CU<13 13<S1CU<23 23<S1Cu Excludad/Trend FRANCE Non exposed 0<SiCU<13 13<S1CU<23 23<S1CU Excluded/Trend GERMANYI -- - - Nan exposed 0<S1cu<93 13<S1CU<23 23<g1CU Excludod/Trend GERMANY2 Non exposed 0<S1CU<13 13<S1CU<23 23<S1CU Excludad/Trend GERMANY3 Non exposed 1 0<S1CU<13 13<S1CU<23 23<81CU Fxcluded~Trand ITALY 1 Non exposed 0<S1CU<13 13<S1CU<23 23<S1CU Excluded/Trend ITALY 2 1,00 1.04 ( 0.77- 1.42) 0.49 ( 0.27- 0.91) 1,50 ( 0.88• 2.55) 0.89 4741 1.00 269 0.98 ( 0.74- 1.30) 65 0.71 ( 0.42- 1.19) 39 1,51 ( 0.89- 2.59) 209 0.52 65 1.00 59 0,73 ( 0.37• 1.43) 16 0.69 ( 0.24- 2.01) 8 0.96 ( 0.26- 3.54) 0 0.79 34 21 3 6 12 153 T52 7 7 t0 1.00 1•16 ( 1.08 f, 1.98 ( 0•3f 66 98 t.oo 49 45 1.12 ( 1 6 11 0.52 ( 71 E 0,91 ( Y4 + 2 0.50 22 35 1.00 1 7 14 0.80 ( 0 1 0.00 { 1~ 1 1,82 ( t 1 0.97 16 123 1.00 16 69 0.98 ( ~ 2 9 0.87 (, 2 7 1.13 ( 41 t3 0.95 0.57- 2,37) 0.25- 4.74) 0.58• 6.78) 0.63- 0.17- 0.28- ( 2.00)I 1.53) 2.93)~ 0.24- 2.67) 0.00-99.99) 0.10-33.48) 0.41- 2.34) 0.16- 4.79) 0.19- 6.57) 1.00 1.01 0.78 1.64 0.09 ( 0.77- ( 0.48- ( 0.95- 1.31) 1.27) 2.49) 1.00 1.01 ( 0.49 ( 1.49 ( 0.09 1 0.74- 1.38) 0.26- 0.91) 1 0.87• 2.53) E 1.00 1.04 0.49 1.50 0.88 ( 0.77• ( 0.27- ( 0.88- ( 1.00 1.42)~ 1.01 ( 0.91) 0.49 ( 2.55)~ 1.49 ( 0.90 0.74- 1-38) 0.26- 0.91) 0.87- 2.53) 1.00 1.00 0.98 ( 0.73- 1.31) 1.01 ( 0.72- 1.42) 0.73 ( 0.43- 1.24) 0.46 ( 0.24- 0.90) 1.60 ( 0.93- 2.75) 1.70 ( 0.94- 3.05) 0.54 I 0.55 ( 1.00 1.00 0.55 ( 0.25- 1.20)~ 0.59 ( 0.22- 1.62) 0.76 ( 0.25- 2.28) 0.25 ( 0.03- 2.27) 0.81 ( 0.20- 3.24) 1.99 ( 0.37•10.73) 0.73 1 0.77 1.00 1.00 1•19 ( 0.53• 2.65) 1.13 ( 0.50- 2.54) 0.82 ( 0.15- 4.56) 0.93 ( 0.16- 5.25) 1.90 (, 0.53. 6.83) 1.71 ( 0.47- 6.26) 0.40 0.40 F 1.00 1.00 1.04 ( 0.58- 1.87) 0.99 ( 0.54- 1.78) 0.53 ( 0.18- 1.57) 0.50 ( 0.17- 1.51) 0.85 ( 0.26• 2.75) 0.87 ( 0,27- 2.84) 0.46 0.47 1.00 1.00 0.74 ( 0.22- ~ 2.56) 0.46 ( 0.12- 1-74) 0.00 ( 0.00-9 9.99) 0.52 ( 0.00-99.99) 1.37 (, 0,06-2 9.72)~ 0.93 ( 0.04•20.96) 0.98 0.82 1.00 1•00 ~ 1.27 ( 0.52- 3.15) 1•11 ( 0.44- 2.79) 1.19 ( 0.21- 6.74) 1•00 ( 0.17- 5.82) 1.62 ( 0.27- 9.75) 1,40 ( 0.23- 8.54) 0.80 0.81 OR(4) 95•/. CI I OR(S) 95% Ct 1.00 1•00 1.02 ( 0.79- 1.31) 0.98 ( 0.74- 1.31) 0.94 (, 0.60- 1.47) 0.69 ( 0.41- 1.16) 1.68 ( 1.06• 2.65) 1.53 ( 0.89• 2.61) 0.09 0.09 1.00 1.00.(, 0.75- 1.32) 0.74 ( 0.44- 1.26) 1.54 ( 0.90- 2.64) 0.61 1.00 0.71 ( 0.36- 1.40) 0.69 ( 0.24- 2.01) 0.94 ( 0.25- 3.51) 0.77 1.00 1.20 ( 0.58- 2.47) 1.12 ( 0.25- 4.95) 2.05 ( 0.60• 7.06) 0.32 1.00 1.12 ( 0.63- 1.99) 0.52 ( 0.17- 1.53) 0.91 ( 0.28- 2.93) 0.50 1.00 0.89 ( 0.25- 3.18) 0.00 ( 0.00-99.99) 1.86 ( 0.10-34.01) 0.96 1.00 1.25 ( 0.50• 3.15) 1.06 ( 0.19- 5.94) 1.39 ( 0.23- 8.21) 0.95 1.00 0.98 ( 0•74- 1-31) 0.69 ( 0•41- 1•16) 1.53 ( 0.89- 2.61) 0.54 1.00 0.71 ( 0.36- 1.40) 0.67 ( 0.23- 1.96) 0.98 ( 0.26• 3.63) 0.80 1.00 1.33 ( 0.64- 2.75) 1•08 ( 0.24- 4.85) 2.13 ( 0.61• 7.49) 0.33 1.00 1•10 ( 0.61- 1.96) 0.52 ( 0.18• 1.55) 0.91 ( 0.28- 2.93) 0.51 1.00 0.60 ( 0.17- 2.14) 0.00 ( 0.00-99.99) 1.97 ( 0.11•35,57) 0.95 j E Non exposed 10 106 1,00 1.00 1.00 1.00 O<S1CU<.13 6 50 0.47 ( 0.14- 1.58) 0.37 ( 0.09- 1.44) 0,51 ( 0.10- 2.69) 0.48 ( 0.74- 1.62) 93<S1CU<23 0 6 0.00 { 0.00-99.99) 0.00 ( 0.00-99.99) 0.00 ( 0-00-99.99) 0.00 ( 0.00-99.99) 23<$1CU 2 6 1,21 ( 0.19- 7.67) 1.46 ( 0.22• 9.82) 1.58 ( 0.11-22.90) 1.32 ( 0.21- 8.54) E fixcluded/Trend Y 5 0.97 0.74 0.80 1.00 ITALY 3 Non axposmo 0<S1CU<r13 13<S1CU<23 CU 29<S1 wxcludod/Trend PORTL)GAl. 1 4 23 1,00 1.00 1.00 t.00 1.00 ~ 6 6 6.33 ( 1.05-38.35) 4.78 ( 0•72-31•83)1 2.20 ( 0•26•18•34) 5.89 ( 0.95-36.57) 5.07 ( 0.75-34.30) 3 9 1.32 ( 0.21- 8.151 1.47 ( 0.21•t0.30)1 0.65 { 0.07• 5.83) 1.35 ( 0.21• 8.48) 1.71 ( 0.23-12.67} 2 2.56 ( 0.14•45.72) 3.36 (, 0•14-82•02)199.99 ( 0,00-99.99) 2.65 ( 0.15-48.45) 99.99 ( 0.00-99.99) ~ 2 10 0.99 0.90 ~ 0.97 0.93 0.97 Non mxpasma 29 25 1.00 ( 1.00 0<S1CUu13 ~ 9 11 0.78 ( 0.25- 2.40) t (p 0.77 ( 0.25- 2.37) 13<S1CUu23 5 2 3.61 ( 0•58-22•55) C 3.45 ( 0.56-21.20) 23<S1CU S 0 99.99 ( 0.00-99.99) 99.99 ( 0.00-99.99) ~ i kxcl4ded/Trand~ ' t 0.02 0.02 PORTUGAL2 Non mxpOSetl 0<S1CU<13 13<S1CU<23 23<S1CU rcludod/Trend E SPAIN 16 38 1.00 1.00 1.00 8 11 3.51 ( 0.88-13,97) 1.83 ( 0.37- 8.90) 2•97 ( 0,72-12•23) 41 0 99.99 ( 0.00-99.99) 99.99 ( 0.00-99.99) ~ 99.99 ( 0•00-99•99) 2 i l 10.35 ( 0,63-99.99) 8.03 ( 0.46-140.8) 9.90 ( 0•63•99,99) ~ 3 3 1 0.03 ~ 0.02 7 € 0.03 ~ mXpOSmd Non 23 50 1.00 1.00 1.00 1.00 1.00 0<31CU<13 20 48 0.89 ( 0.41- 1.93) 0.94 ( 0.42- 2.13) 0.93 ( 0.39• 2.18) 0.91 ( 0,41- 2.00) 0.86 ( 0.39- 1.90) 13<S7CU<23 2 19 0.24 ( 0.05• 1.15) 0.27 ( 0.05- 1.32) 0.26 ( 0.05- 1.30) 0.28 ( 0.06- 1.36) 0.24 ( 0.05- 1.15) 23<S1CU 9 15 1.41 ( 0.50- 3.97) 1.61 ( 0.54• 4.77) 1.64 ( 0.54. 4.93) 1.42 ( 0.50- 4.02) 1.50 ( 0.53• 4.28) Excluded/Trond 17 1 27 O,B4 0.88 0.87 0.82 0,7s SWEDEN Non exposed 38/ 62 1.00 1.00 r 1.00 1•00 0<S1CU<13 2' 2 46 88 ( 0 45- 1 74) 0 0 86 ( 43- 1 71) 0 0.89 ( 45- 1,77) 0 0.90 ( 0 45- 1.78) 13<S1CU<23 `I 5 1 3 . 3.17 ( . . 0.68-14.89) . 3.82 { . . 0.78-18,69) 3.32 ( . 0•71-15.57) 3.09 ( . 0•65-14.67) 3<51CU 3 5 85 0 55 61 77 5 93 ( 64 54 57 0 6 04 0 57 63 55 6 98 0 7 65 07 2 Exc1 uded/Tr#nd 1 2 0 . ( 0.07 . - . ) . 0.06 . - ) . . ( 0.06 . - . ) . ( 0.05 , - 5. ) UNITED K)NGDOM ~ •:063,9 g~,~, 370 exel uded/Trend J 140 (1) Model /ncluda sex, eenter, sex'centerand age (2) Model Indude sex, center, sex'center, age and proportion of residential type in the last 35 yrs (REUP) (3) Model trtc)ude sex, center, sex'center, age, proportion of residential type in the last 35 yrs (REUP) and educational level (EDUC) (4) Model inClUde sex, center, sex'center, age and duration of exposure to list A agents (OCLAY) (5) Model include sex, center, sex'center, age and frequency consumption of vegetables (VEGE) Controls ~ ORI1 95'/. CI OR(2) 95'/. CI E CR(3) 95% CI 1.00 1.00 ( 0.78- 1.28) 0.89 ( 0.57- 1.39) 1.64 ( 1.04- 2.59) 778 411 83 55 Excludad/Trendl 87! 215! 0.09 1 Risk estimates - SDouse

C SICS Spouse, Cumulative exposure of smoking spouse (packs/day x years) ALL CFWT€RS i.avd of ex sure Cas es Contr ols OR(1) 95% CI OR(2) 95% CI Non mxposmd 208 645 1,00 1.00 0<S1C8<r35 142 372 1.00 ( 0.76- 1.32) 1.03 ( 0.76- 1.39) 35<S1CS<52 34 76 1.13 ( 0.71• 1.80) 1.11 ( 0.67- 1.83) 52<S1CS ~ 30 51 1.38 ( 0.83- 2.30) 1.16 ( 0.65- 2.04) EXCludrd/Trand 236 998 0.19 0.19 ALL CENTM WITH EDUCATIONAL LEVEL AND TYPE OF RESIDENCE Non mxposmd 0<S1CS<r35 35<S1CS<52 21 52<81CS 17 E.rcludid/Trtnd 294 ALL CENTERS WITH D(ETAR DATA 1.00 0.99 ( 0.67• 1.45) 0.97 ( 0.54- 1.74) 1.19 ( 0.62- 2.29) 5701 0.94 OR(3) 95% CI j OR(4) 95%. CI ) OR(S) 95% CI ) 1.00 1.00 1.00 0.99 ( 0.68- 1•46) 1.02 ( 0.77- 1.36) 1.00 ( 0.72- 1.41) 0.99 ( 0.55- 1.79) 1•21 ( 0.75- 1.94) 1.10 ( 0.63- 1.90) 1.22 ( 0.63• 2.36) 1•44 ( 0.86- 2.41) 0.92 ( 0.48- 1.78) 0.21 ( 0.20 0.21 1.00 1.00 1.00 0.99 ( 0.68- 1.46) 1.01 ( 0.69- 1.50) 1.08 ( 0.69- 1.69) 0.99 ( 0.55- 1.79) 1.05 ( 0.58- 1.91)l 1•04 ( 0•53- 2.03) 1.22 ( 0.63- 2.36) 1.24 ( 0.64• 2.40) 1.08 ( 0.50- 2.32) 0.92 0.94 0.90 [ Non mxpoaad 134 341 1.00 ( 1.00 1.00 1•00 1.00 i 0<31CS<35 99 220 1.01 ( 0.72- 1.42) 1.06 ( 0.74- 1.51) 1.09 ( 0.70- 1.72) 1.03 ( 0.73- 1.45) 1.00 ( 0.72- 1.41) 35<S1CS<r52 26 54 1.12 ( 0.65- 1,94) 1.17 ( 0.66- 2.07) 1.12 ( 0.57- 2•18) 1.19 ( 0.69- 2•07) 1.10 ( 0.63- 1•90) 62<S1CS 16 37 0.94 ( 0•49• t.81) 0.93 ( 0.47• 1.83) 1.16 ( 0.54- 2.50) 0.97 ( 0.50- 1.86) 0.92 ( 0.48• 1.78) frcludtd/Trond 294 404 0.95 1 0.93 0.90 0.96 0.91 FRANCE expos®d Non 38 65 1.00 1.00 1.00 1.00 1.00 0<S1CS<35 25 59 0•78 ( 0.40- 1.52) 0.64 ( 0.29- 1.38) 0.54 ( 0.19- 1.51) 0.75 ( 0.38- 1.49) 0.76 ( 0.39- 1.49) 3s<slcs<s2 7 17 0.78 ( 0.28- 2.14) 0.62 ( 0.21- i.87) i 0.48 ( 0.10- 2.29) 0.78 ( 0.28- 2.16) 0.75 ( 0.27- 2.08) 52<BtCS 4 9 0.86 ( 0.23• 3.16) 0.83 ( 0.21- 3.19) 3.95 ( 0.67•23.27) 0.84 ( 0.23• 3.10)~ 0.89 ( 0.24- 3.29) Ercludsd/Trtnd 3 1 0.68 ( 0.60 0.63 0.65 0.68 ( GERMANY1 Non mxpoamd 0<S1CS<35 35<SiCS<r52 52<S1CS Ercluded/fnnd GERMANY2 34 153 1.00 1.00 1.00 1.00 1.00 24 56 1.22 ( 0.60- 2.46) 1.30 ( 0.59- 2.85) 1.23 ( 0.55- 2.72) 1.27 { 0.62- 2.59) 1.41 ( 0.68- 2.90) 61 6 2.86 ( 0.80-10.23) 3.56 ( 0.78•16.21) 4.05 ( 0.88-16.58) 3.03 ( 0.84•10.96) 2.92 ( 0.80-10.61) 2 12 0.31 ( 0.06• 1.56) 0.31 ( 0.06- 1.62)l 0.26 ( 0.05• 1.37) 0.32 ( 0.06- i.60) 0.28 ( 0.05- 1.45) ~ f0~ 2 0.62 0.53 E 0.46 0.60 0.53 Excludtd/Trend ITALY 1 Non mxposmd Oe$1CSc35 35<$1CS<52 52<S1CS Excludtd/rrend ITALY 2 Non expoamtl 0<stcs<s3s 35<S10S<R52 52<S10S ts 123 1.00 1.00 1.00 1.00 15 72 0.86 ( 0.36- 2•OS) 1.12 ( 0.45- 2.77) 0.96 { 0.38- 2.42) 1.11 ( 0.44- 2.80) 2 11 0.74 { 0.14- 4,00) 1.11 ( 0.20• 6.20) 0.96 ( 0.17- 5.41) 0.96 ( 0.18• 5.43) 3 7~ 1.74 ( 0.37. 8.23) 2.91 ( 0.57-14.72) 2.46 ( 0.46-12.47) 2.35 ( 0.47-11.65) 4 8 0.66 0.55 0.56 ~ 0.65 10 106 t.oo 1.00 1.00 1.00 r 53 0.38 ( 0.11- 1,35) 0.30 { 0.07- 1.26) 0.33 ( 0.06- 1.94) 0.35 ( 0.10- i.25) 5 0.67 ( 0.06- 7.12) 0.56 ( 0.05- 6.30) 0.66 ( 0.04- 9.74) 0.72 ( 0.07- 7.72) E 2 5 1.67 ( 0.24-11.44) 1.98 ( 0.27-14.72) 10.96 ( 0.30•99.99) 1.89 ( 0.27-13.38) 1) Exc1 udtd/Trtnd! 41 0.71 0.58 0.75 0.64 ITALY 3 Non mxpoaad 0<S1CS<35 35<S1C8<r52 52<81CS 7 4 23 1.00 1.00 1.00 1.00 1.00 6 14 1.98 ( 0.80- 9.76) 1.77 ( 0.33- 9.35) 0.73 ( 0.11- 4.59) 1.85 ( 0.36- 9,55) 2.09 ( 0.34-12.66) ~ 3 5 3.05 ( 0.42-21.88) 6.45 ( 0.62•67.37} 8.34 ( 0.39-99.99) 3.29 ( 0.44-24.56) 5.90 ( 0.62-56.34) 2 2I 4.66 ( 0.38-57.41) 1.16 ( 0.06-20.88)I 0.81 ( 0.03-22.29)~ 4.87 ( 0.38-62.26) 12.70 ( 0.51-99.99) ~rc1uded/Trtnd .° 6( 0.18 0.18 t 0.09 0.16 0.20 Non axposod 29 25 1 00 C 1.00 0<S1CS<35 13 12 1.14 ( 0.41- 3.20) ~ 1.12 ( 0.40- 3.13) 35<S1CS<.52 2 1 3.12 ( 0.25•39•45) 2.96 ( 0.24-37.01) 52<S1CS 5 1 7.06 ( 0.71-70.60)~ €j 6.73 { 0.68-66.53) r'XCludtd/Trend 0 0 0. b7 p 0. 07 NOn mXpOamtl 16 38 1.00 1.00 1.00 ( 0<S1CS<r35 9 12 4•45 ( 1.10-17.94) 3.04 ( 0.65-14.22) 3.99 ( 0.97•16.45) 35<S1CS<r52 ~ 3 3 5•22 ( 0.65•42.01) 2.86 ( 0.32-25.54) 5.07 ( 0.64-39.89) 52<S1CS , 4~ OI 99.99 ( 0.00•99.99) 99.99 ( 0.00•99.99) 99.99 ( 0.00-99.99) 1 0 0.00 ( 0.00 ~ 0.00 Non mxposod 23 so 1.00 1.oa 1.00 1.00 1.00 Q<S/CS<35 22 50 0.91 ( 0.42• 1•94) 0.99 ( 0.44- 2.23) 0.98 ( 0.42- 2.28) 0.93 ( 0.43• 2.01) 0.92 ( 0.42- 1.99) 35<SiCS<•52 7 26 0.63 { 0.23• t.75) 0.7i ( 0.25- 2.03) 0.66 ( 0.23- i.92J 0.68 ( 0.24- t.94j 0.62 ( 0.22- 9.76j E ~ 52<S1C3 6 1 2~ 1.14 ( 0.36- 3.64) 1.17 (, 0.35- 3.94) 1.25 ( 0.36- 4.30) 1.13 ( 0.35- 3.63) 1.04 ( 0.32• 3.38) clOded/Trsnd X /9 ~ 1 0.80 0.70 0.73 0.77 0.71 E SWEDEN Non exposed 38 62 1,00 1•00 1.00 1.00 <S1CS<.35 0 23 44 0.97 ( 0.50- 1.92) 0.95 ( 0.48- 1.89) 0.99 (, 0.50- 1.96) 0.99 ( 0.50- 1.95)~ 35<S1CS<52 ~ 31 2 2.86 ( 0.42•1 9.27) 2.81 ( 0.41-19.35) 2.94 ( 0.44-19.77) 3.08 ( 0.46-20.81) 5g<S1 EfEfEf CS 21 3 1.50 ( 0.22•10•08) 1.52 ( 0.22•10.33) 1.51 ( 0.22-10.17) 1.63 ( 0.24-11.08) Fxcludtd/Trend~ 41 1 0.45 0.45 E 0.42 ~ 0.38 N UNITED KIGDOM ,Fxc1 udtd/Trend 261 140 (1) Modc! tndude sox ecnlcr, sex'center and age (2) Modol indude sex, eenter, 5ex'center, age and proportlon of residential type in the last 35 yrs (REUP) (3) Model IndudC sex, center, sex'center, age, proportion of residential type in the Iast 35 yrs (REUP) and educatfonel level (EDUC) (4) MoCLH rnWd@ sex, center, sex'cEnter, age and durauon of exposure t0 list A agents (OCLAY) (5) Model Include sex, center, aex'center, age and frequency consumption of vegetables (VEGE) otisa

Spouse, Duration (hours/day x years) MENONLY Lev.1 ot ox surn Cases ) Controls K£.~ S1bt1~~35 135 499 196<S10H<•223 2 6 223<S1DH 0 1 OR(1 95% Cl ( OR(2) 95% Cl OR 3) 95% Cl ~ OR(4) 95% Cl OR(5' 95% Cl ) 1.00 1.00 1.00 1.00 1.00 1.86 ( 0.23-14.$1) 1.79 ( 0.17-18.45) 0.00 ( 0.00-99.99) 1.95 ( 0.24-15.75) 2.63 ( 0.20-34.51) 0.00 ( 0.00-99.99) 0.00 ( 0.00-99.99) 0.00 ( 0.00•99.99) Excluded/rrand ! 4 25 0.62 ~ 0.58 0.58 ~ 0.60 ~ 0.62 ~ WOMEN ONLY HE,, 510N<136 135<S1DH<.223 223<SlDH 327 675 1,00 1.00 1.00 1.00 1.00 42 75 1.24 ( 0.82- 1.90) 1.42 ( 0.91- 2.22) 1.37 ( 0.82- 2.27) t•34 ( 0.87- 2.06) 1.46 ( 0.89- 2.37)i ~ 41 52 1.88 ( 1.18- 3.00) 1.90 ( 1.14- 3.14) 1.57 (, 0.90• 2.74) 1.92 ( 1.20- 3.06) 1.58 ( 0.87- 2.86) cluded/Trend~ Ex 99 209 ~ 0.01 1 0.01 ~ 0.01 0,01 ~ 0.07 POPULA?1ON BASED STUDIES S1DH<.135 NE., 293 850~ 1.00 1.00 1•00 1.00 1.00 135<S1DH<•229 23 ! 38 1.49 ( 0.83- 2.67) 1.52 ( 0.84- 2.73) 1 1.64 ( 0.80- 2.99) 1.62 ( 0.89- 2.94) 2.38 ( 1.15- 4.93)1 223<S1DN 16 ! 25 1.74 ( 0.87- 3.49) ( 1.81 ( 0.90- 3.65) 1.70 ( 0.79• 3.68) 1.77 3.57) 2.07 ( 0.80- 5.38) ~Srcludad/Trond 46 1 0.05 37 0.05 0.05 E 0.05 ~ 0.05 HOSPITAL BASED STUDIES NE.s S1DH<135 169 324 ~ 135tS1DH<•223 21 43 223<SlDH 25 28 ExoludedIrrendl 3t 5111 WITHOUT OCCASIONAL SMOKERS NE.r S1DN<135 341 ~ 135<S1DH<223 32 223<S1DH 34 79 NE., S10N«135 135<S10H<223 223<S1DH Excludad/Trand 6 AGE 1551 19 1.00 1.00 1.00 1.00 1.00 1.06 ( 0.58- 1.91) 1•26 ( 0.65- 2.47) 1.12 ( 0.51- 2.47) 1.15 ( 0.63- 2.09) 0.97 ( 0.49- 1.92)i 2.03 ( 1.08• 3•80) 1.97 ( 0.94- 4.11) 1.52 ( 0.67- 3.48) 2.06 ( 1.10- 3.86)f 1.28 ( 0.58- 2.81) € 0.06 0.06 0.06 0.06 0.07 ~ 1.00 1.00 1.00 1.00 1•00 1.12 ( 0.69- 1.82) 1.30 ( 0.78- 2.17) 1.30 ( 0.74- 2.28)1 1.21 ( 0.74- 1.99) 1.46 ( 0.84- 2.55) 1.86 ( 1.11- 3.11) 1.78 ( 1.01. 3.14) 1.57 ( 0.85- 2.90)1 1.90 ( 1.14- 3.19) 1.47 ( 0.74- 2.89) 0.03 ~ 0.03 0.03 - I 0.03 0.03 1.00 1.00 1.00 1.00 1.00 0.10 (, 0.01- 0.80) 0.00 ( 0.00-99.99) 0.00 ( 0.00•99.99) 0.09 ( 0.01- 0.76) 0.00 ( 0.00-99.99) 0.95 7 0.19- 4.87) 2.45 ( 0.34-17.47) 2.17 ( 0.30-15.54) 0.99 ( 0.19- 5.15) 99.99 ( 0.00-99.99) 0.11 0.1 0.10 0.09 E 0.11 .~ S1DH<e135 i45 N€ 422 1.00 1.00 1.00 1.00 1.00 ,35<S1DH <• 22 323 <•223 22 3.19 ( 1.61- 6.30) 2.79 ( 1.37- 569) . 2.65 ( 1.13- 6.21) 3.75 ( 1.85- 7.60)i 5.00 ( 2.05-12.19) 223<s1DH 12! l 20 1.65 ( 0.71- 3.81) II ~ 1.22 ( 0.47- 3 .20) 1.26 ( 0.44- 3.63) 1.64 f, 0.71- 3.61)1 1.76 ( 0.58- 5.33) 90 rXCludad/Trend ~ 88 ~ 0.01 ~ 0.01 ~ 0.01 0.01 ~ 0.01 ~ 5-84 YEARS AGE 65+ YEARS H€,, $10H<.135 135<S1DH<•223 223<SlDH 72 431 1.00 1.00 1.00 1.00 1.00 20 44 1.02 ( 0.56- 1.86) 1.27 { 0.68- 2.38) 1.43 ( 0.70- 2.92) 1.08 ( 0.59• 1.98) 1.15 ( 0.60- 2.20) ~ f 26 27 2.60 ( 1.39• 4.87) 2.61 ( 1.35- 5.07) 2.16 ( 1.01- 4.59) 2.63 ( 1.40- 4.92) 1.68 ( 0.79- 3.55) Excludedlrr.nd 57 127 0.01 0•O1 0.02 0.01 ~ 0.01 HISTOLOGICALLY CONFIRMED DIAGNOSIS NE., S1DH<135 448 ;174 1.00 1.00 1.00 1.00 1.00 ) 136<S10H<223 43 81 1.26 ( 0.83. 1.91) 1.42 ( 0.91- 2.21) ~ 1.34 C 0.81- 2.21) { 1.35 ( 0.89- 2.07)1 1.50 ( 0.93- 2.42) 223<S1DH 39 53 1.81 ( 1.13- 2.89) 1.77 ( 1.06- 2.95) 1.58 ( 0.91- 2.75) 1.83 ( 1.15- 2.94)j 1.59 { 0.88• 2.88) f Exc1 uded/Trend~ 97 234 0.01 ~ 0.01 ~ 0.01 0.01 Il 0.01 SQUAMOUS CELL CARCINOMA NE., 510H<4135 73 1174 1.00 1.00 I 1.00 1.00 1.00 135<S10H<223 ~ 7 81 1.46 ( 0.61- 3.49) 1.95 { 0.81• 4.70) 1.86 ( 0.66• 5.28) 1.56 ( 0.65• 3.75) 1.50 ( 0.53- 4.22 ) p 223<SlDH 10 531 2.40 ( 1.06• 5.48) 1.75 ( 0.62- 4.93) 1.73 ( 0.59- 5.02) 2.45 { 1.07- 5.60) 1.55 ( 0.48- 5.01) ,;'xc1 uded/Trend i 19~ 2341 0.03 ~ 0.04 € 0.04 0.03 0.04 SMALL CELL CARCINOMA N€,i SiDH<.135 t 46 174 1,00 1.00 1.00 1.00 1.00 135<S10H<223 ~ 6 81 2.39 ( 088- . 6.50) 2.40 ( 0.88- 6.59j1 2.40 ( 0•78• 7.34) 2.49 ( 0.91• 6.82) 2.09 ( 0.69- 6.27) 223tS10H I 2 53 2.15 ( .45•10.41) 0 2.07 ( 0.43-10.07) 2.37 ( 0.48•11.70) 2.14 ( 0.44- 10.32) 1.21 ( 0.14•10.18) E'xcluded!Trsnd~ 15 234 0.08 0.09 0.09 ~ 0.08 0.08 ADENOCARCINOMA ;tE.) S10H<.135 I 245 174 1.00 1.00 1.00 1.00 ! 1.00 135<S1DHtr223 22 81 1.16 { 0.68- 1.96) 1.33 ( 0.76- 2.35) 1.38 ( 0.73- 2.59) 1.24 ( 0.73- 2.12) i 1.45 ( 0.80• 2.61) 223<S10H ) 20 53 1.70 ( 0.95• 3.04)) 1.79 { 0.95- 3.38j 1.42 ( 0.69- 2.90) 1.72 ( 0.96- 3.08) 1.48 ( 0.71- 3.09) Excludtd/Trondl 46 294 0.08 ~ 0.08 0.08 0.09 ~ 0.10 OTHER NE.~ 510H<135 84 1174 1.00 1.00 1.00 1.00 1.00 135<S10H<223 8 81 1.13 { 0.51• 2.51) 1.17 ( 0.49- 2.75) 0.99 ( 0.36- 2.59) 1.22 ( 0.54• 2.72) 1.55 ( 0.64• 3.75) ^a23<$1DH 7 53 1.62 ( 0.67• 3.931 1.80 l, 0.73- 4.43) 1.66 ( 0.63- 4.41) f 1.68 ( 0.69- 4.08) 2.34 ( p.84- 6.45) EXClwtd/TrOndl 16 2341 0.33 ~ 0.36 j 0.36 1 0.32 0.33 >75% OF LIFESPAN IN RURAL AREA OR INTERMED IATE CITIES NE,, 510H<135 177 416 1.00 t.00 1.00 ) 1.00 1.00 135<S10H<•FF3 16 15 2.55 (, 1.13• 5.73) 2.55 ( 1.13- 5.73) 2.30 ( 0.91• 5.82) 'E 2.62 ( 1.16- 5.92) 2.33 ( 0.98- 5.54) 223<SlDH 14 9 4.10 ( 1.52-11.03) 4.10 ( 1.52-17.03) 3.59 ( 1.16-11.13) I 4.22 ( ttt 1.56- 11.38) 2.54 ( 0.88- 7.39) €xcluded/rrand 49 f35 0.00 0.00 0.00 ~ 0.00 ~ 0.00 s7554 OF LIFESPAN IN URBAN AREA N€,, S10H<.135 170 552 1.00 1.00 1.00 i 1.00 1.00 135<51DH<223 I 22 51 1.23 ( 0.69- 2.21) 1.23 ( 0.69- 2.21) 1.27 ( 0.70- 2.31) 1.21 ( 0 6Z 2.35) 1.51 ( 0.76- 2.99) 223tS1DH 18~ 34 1.90 ( 0.99• 3.66) 1.90 ( 0.99- 3.66) ~ 1.90 ( 0.98- 3.67) 1.58 ( 0.77- 3.26) 2.04 ( 0.90- 4.63) fxcluded/Trsndi 34~ 74 0.06 0.06 ~ I 0.06 ~ 0.06 0.07 (1) Modcf inclu<le sox, center, sex•cen(er and age '2) Model indude sex, Center, sex•center, age and proportion of res,dential type in the last 35 yrs (REUP) (3) Model Include sex, center, sex'center, age, proportlon of residential type in the last 35 yrs (REUP) and educational level (EDUC) (4) Model fnclude sex, center, sex'center, age and duration of exposure to list A agents (OCLAY) (S) MOdc( inctuda sex, center, sex-center, agc and frequency consumptlon of vegetables (VEGE) 206:3593364 Risk estimates - Spouse t2Q

S1 UD Spouse, Duration (years) (non overlapping) fTALY 2 E i ota! Exposed Unexposed Exctuded Min 1 P10 01 Median Q3 ( P90 ~ Max ~ Mean Std ~ MM COSei 3 0 3 0 z Contro{f 97 15 ®2 0 4.00 8.00 10.00 16.00 30.00 / 41.00 43.00 20.60 12.90 A11 100 16 85 0 4.00 8.00l 10.00 16.00 30.00~ 41.00 43.00 20.60 12.90 WOn10n CB9CS 16 8 7 1 2.00 2.00 22.00 30.50 34.50 42.00 42.00 27.25 12.25 Controlf 76 49 24 3 4.00 7.00 20.00 29.00 35.00 41.00 51.00 26.84 11.54 Atl 92 57 31 4 2.00 7.00 21.00 29.00 35.00 41.00 51.00 26.89 11.53 All Ce5C3 ~ 19 8 10 1 2.00 2.00 22.00 30.50 34.50 42.00 42.00 27.25 12.26 Contf012 173 64 106 3 4.00 8.00 15.00 27.50 34.50 41.00 51.00 25.38 12.06 All ~ 192 72 116 4 2.00 8.00 15.50 28.00 34.50 41.00 51.00 25.58 12.01 Mei1 Cases 1 1 0 0 11.00 11.00 11.00 11.00 11.00 11.00 11.00 11.00 0.00 Controls 12 2 10 0 13.00 13.00 13.00 20.50 28.00 28.00 28.00~ 20.50 10.61 AA 3 3 10 0 ?1.00 11.00 11.00 13.00 28.00 28.00 28.00 17.33 9.29 WO(T~a1 CSSb3 15 10 4 1 12.00 16.50 24.00 33.00 44.00 46.50 49.00 32.70 12.09 Controls 36 All 53 24 34 13 17 1 2 2.00 2.00 19.00 19.00 25.50 25.00 31.50 31.50 37.50 38.00~ 47.00 47.00 50.00 50.00 30.63 31.24 11.791 11.741 M Ca584 16 11 4 1 11.00 12.00 21.00 31.00 44.00 44.00 49.00 30.73 13.21 COr1llOlS 60 26 23 1 2.00 13.00 25.00 31.00 37.00 47.00 50.00 29.85 11.83 At! ~ 66 37 27 2 2.00 12.001, 24.00 31.00 38.00 47.00 50.00 30.11 12.08 PORTUQALI MGUt CaSOf 16 3 13 0 16.00 16.00 16.00 17.00 30.00 30.00 30.00 21.00 7.81 Controls 8 0 8 0 1 1 All 24 3 21 0 16.00 16.00 16.00 17.00 30.00 ! 30.001 30.00 21.00 7.81 WOrtten Cases 33 17 16 0 2.00 4.00 23.00 34.00 39.00 44.00 46.00 29.24 13.251 Conlf~f 31 14 17~ 0 5.00 11.00 21.00) 26.00 29.00 39.00 42.00 25.36 9.731 AH 64 31 331 0 2.00 11.00 21.00 27.00 37.00 42.00 46.00 27.48 11.771 Afl C95ef 49 20 29 0 2.00 9.50 18.50 28.50 38.00 43.50 46.00 28.00 12.78 Coi1tr01f 39 14 25. 0 5.00 11.00 21.00 26.00 29.00 39.00 42.00 25.36 9.73 A11 88 34 54 0 2.00 11.00 20.00 26.SOC 37.001 42.00 46.00 26.91 11.53 PORTUGAL2 Men CaSet :0 0 10 0 I Controls 7~ 01 17 0 ~ € ~ Alt 27~ 01 27 0 III WOmCn Caaef 23 16 6 1 3.00~ 8.00 19.00 28.50 38.00 43.00 46.00 27.25/ 13.05 ConlrGf 36 15 21 0 1.00 3.00 10.00 17.00 31.00 37.00 42.00 19.27~ 12.62 A!I 69+ 31 27 1.00I 6.00 11.00 21.00 34.00 41.00 46.00 23.39 13.26 AII Cases COntr01ID AII 331 16 531 15 861 31 16 38 54 0I 1 3.001 8.00 1.001 3.00 1.00~ 6.00 19.00 10.00 11.00 28.50 17.00 21.00 38.00 43.00 31.00 37.00 34.00 41.00 46.00 42.00 46.00 27.25 13.05 19.27 12.621 23.39 13.261 SPAIN MGr1 Cases 6 1 5 0 31.00 31.00 31.OOI 31.00 31.00 31.00 31.00 31.00 0.001 Conlrolf 13 0 13 0 ~ ( 1 All 19 1 ~ 18 0 31.00~ 31.00 31.00 31.00 31.00 31.00 31.00 31.00 0.00 Wo019n f)JSQf 65 t - 341 18 13 ':.00 8.00 20.00I 30.00 36.00 37.00 44.00 25.74 12.02 Controls 146 911 37 18 3.00~ 9.00 19.00~ 31.00 40.00 44.00 51.00 29.04 13.00 A11 211 1251 55 31 1,00 9.00 20.00 30.00 38.00i 43.00 51.00 28.14 i2.78 AII C856f € 71 35 23 13 1.00 8.00 20.00 30.00 36.00 37.00 44.00 25.891 11.88 ' COnlrolf ! 159 31 50 18 3.00 9.00 19.00 37.00 40.00 44.00 51.00 29.04' ~ 13.00 AI1 € 230 128 731 31 1.00 9.00 20.00 30.00 38.00 43.00 51.00 28.17 12.73 SWEDEN Men CmSCf I 23 8 15 0, 1.00 1.00 3.00 15.00 32.50 44.00 44.00 18.25 16.31 Controls 36 9 27 0I 2,00 2 00~ 5.00 8.00 10.00 19.00 19.00 8.67 5.59 All 69 17 42 0 1.00 2.001 4.00 8.00 16.00 34.00 44.00 13.18 12.50 WOn'ICn CSSCf 47 241 23 0 2.00 3.00 8.50 19.001 30.00 34.00 48.00 18.96 12.97 Controls 76 411 35 0 1.00 5.00 8.00 19.001 29.00 35.00 52.001 20.10 12.93 All 123 65 58 I 0 1.00 3.00 8.00 19.001 29.00 35.00 52.00 19.68 12.86 A11 CiSCf 70 Ccxllraf I 112 AH 162 32 38 50 62 82 100 0 1.00 0 1 1.00 0 1.00 2.00 5.50 3.50 6.00 3.00 6.00 17.00 31.00 16.00 28.00 16.00 29.00 34.00 34.50 34.00 48.00 52.00 52.00 18.78 18.04 18.33 ?3.60 12.70~ 12.98 UNPfED KINGDOM Men ~ Cases 3, 1 14 3 Controls 17 4 All Woullen Caf03 C 23 17 Contraf ' 1261, '7 AA ? 1491 94 A71 CaSCf 26 18 2 0 10.00 10.00 10.00 10.00 10.00 10.00 10.00 10.00 0.00 11 0 40.00 40.00 40.00 43.001 43.00 43.00 43.00 42.00~ 1.73 13 0 10.00 10.00 25.00 41.50 43.00 43.00 43.00 34.00, 16.061 6 0 2.00 2.00/ 11.00 31.001 39.00 43.00 49.00 27.65 15.52 I 49 0 3.00 10.001 20.00 28.001 36.001 45.00 49.00 27.75 12.08~ 55 0 2.00 10.00 20.00 29.00 38.00 45.00 49.00 27.73 12.68 8 0 2.00 2.00 10.00 30.50 39.00 43.00 49.00 26.67 15.62 Controlf 140 801 60 0 3.00 10.001 20.50 28.50( 38.50 45.00 49.00 28.29 12.16 All 166 98 68 0 2.00 10.001 20.00 29.501 39.00 45.00 49.00 27.99 12.79 22063593386 _ 4_- Ile~r.rintive. ctatiGtias_-_Soouse_-

2.3.4Spouse and other cohdb-AtUnts Risk estimates

:_S1UD Spouse, Duration (years) (non overlapping) MEN ONLY ~.RVN OT V,pO?VR t Gzsz Cortrolz Non @xposed 118 462 0<S1UD<34 21 59 34<S1UD<42 42<S1UD I 1 4 6rcludrd/Trrnd WOMEN ONLY Non @xpos@n 0<S1UD<34 34<$1 UDu42 42<31UD Excl udrd/Trrnd POPULATION ®ASED STUDIES Non @xposen 0<S1UD<r34 34<StUO<.42 42<S1UD €atcl t~drd/Trrnd HOSPITAL BASED STUDIES Non ekposen 0<S1U0<r34 34<S1UD<42 42<SiUD 187 202 64 37 19 Excludrd/Trrndl 15 WITHOUT OCCASIONAL SMOKERS eXpoS@tl Non 0<$1U0<r34 34<StUDtr42 42<31UD 33 1.07 ( 0.56- 2.04) 1.13 (- 0.59- 2.16) 4 0.26 1 0.28 1.00 1.00 0.99 ( 0.75- 1.29) 1.50 ( 1.00- 2.26) 1.02 (, 0.62- 1.66) 0.16 ! 1 .00 1.12 ( 0.75- 1.67) 1.05 ( 0.66- 1.68) 1.28 ( 0.70- 2.33) 0.99 { 0.49- 1.98) 1.07 ( 0.53- 2.19) 0.86 ( 0.38. 1.92) 0.49 1 0.52 1.00 1.00 1.11 ( 0.74- 1.66) 0.96 ( 0.60- 1.54) 1.29 ( 0.71- 2.37) 0.75 ( 0.36- 1.55) 1.23 ( 0.59- 2.53) 0.65 ( 0.28- ~ 1.52) 0.49 0.56 225 593 1.00 1.00 1.00 1.00 1.00 1 162 346 1.06 ( 0.81- 1.41) 1.05 { 0.78- 1.42) 0.91 ( 0.65- 1.26) 1.05 f- 0.80- 1.40) 1.03 ( 0.75- 1.42) 48f 83 1.46 ( 0.94- 2.25) 1.35 ( 0.85- 2.15) 1.31 { 0.78- 2.19) 1.51 ( 0.98- 2.35) 1.33 ( 0.80• 2.23) l 34~ 61 1.15 ( 0.70- 1.91) 1.14 ( 0.67- 1.94) 0.99 ( 0.56- 1.76) 1.29 ( 0.77- 2,15) 0.92 (, 0.52- 1.64) fxclGCfrd/Trrnd 17 21 0.18 0.17 , 0.28 ' 0.18 g 0.19 AGE <55 YEARS Non expos@q 94 215 1.00 1.00 1.00 1.00 1 •00 Ot$lU0<34 66 139 0,97 ( 0.63- 1•50)~ 1.02 ( 0.63- 1.65) 1.08 ( 0.61- 1.91) 0.96 ( 0.62- 1.50) t-05 ( 0,64- 1•72)'t 34<$lU0<42 ~ 3 2 2.78 ( 0.35•22.34) 2.49 ( 0.25-25.23) 6.98 ( 0.28-99.99) 2.78 ( 0.34-22.a7) 2.39 ( 0.20-28.77)~ Exclt7drd/Trrndl lli 2 5• 0.85 ~ 0.83 0.90 0.92 ~ o.e6 AGE 55-G4 YEARS NOn @XpoS@q 0<$tUD<34 34<S1U0<42 42<31UD 98 309 1.00 1.00 1.00 1.00 1.00 69 184 0.97 ( 0.63- 1.49) 0.85 ( 0.54- 1.34) 0.65 ( 0.39- 1.09) 0.94 ( 0.61- 1.46) 1 0.86 ( 0.52- 1•41) ~ 33 45! 1.84 ( 1.03- 3.29) 1.55 ( 0.84- 2.87) 1.18 ( 0.59- 2.33) 1.87 { 1.04- 3.35) 1.69 ( 0,85• 3.34) 3~ 5 1.47 ( 0.31- 7.01) 1.44 ( 0.30• 6.86) 1.81 { 0.30-10.82) 2.00 ( 0.38-10.56)~ 0.94 ( 0.14- 6.12) ExclUdrd/Trandi 1 9 0.10 o. fo 1 0.11 0.10 0.11 AGE 65+ YEARS Non @%poSeq 13 314 1.00 L 00 1.00 1.00 1.00 0<StUD<.34 68 175 1.17 t 0.80. 1.72) 1.26 { 0.85• 1.88) 1.30 1 0.80- 2.10) 1.20 ( 0.82- 1.76) 7.22 { 0.80- 1.86) 34<S1U0<a42 29 56 1.51 ( 0.87• 2.63) 7.67 ( 0.94- 2.97) 2.13 ( 7.09- 4.15) 1.56 { 0.89- 2.72) 1.66 ( 0.88• 3.13) q2t31UD 35 75 1.10 ( 0.66. 1.81) 1.09 ( O.sa- 1.85) 0.92 ( 0.50- 1.71) 1.19 ( 0.72- 1•98) 0.97 ( 0.55- 1.71) ExcludrdfTrrnd( 101 9 0.33 0.32 0.42 0.31 1 0.34 ; HISTOLOGICALLY CONFIRMED DIAGNOSIS i0n @%poS@q 296 838 1.00 1,00 ; 1.00 1.00 1.00 0<S1UD<r34 ~15 ~ 498 1.02 { 0.81- 7.30) 1.04 ( 0.80• 1.33) 1.00 ( 0.75- 7.34) 1.03 ( 0.81- 1.31) 1.04 { 0.79• t.36) 34<S1U0<42 103 1 L 57 ( 1.07- 2.30) 1.52 ( 1.01- 2.28)~ 1.54 ( 0.98- 2.a2) 1.62 ( 1.10- 2.39) 1.64 ( 1.05- 2.55) 42t$1UD 35 80 0.99 ( 0.62- 1.57) 0.96 ( 0.59• 1.57) 0.94 ( 0.55• 1.61)~ 1.08 ( 0.67- 1.73) 0.93 ( 0.56- f.56) 5xcludrd/Trrnd ~ 1.9 63! 0.21 0.21 ~ 0.29 1 0.2/ 0.23 SQUAMOUS CELL CARCINOMA ?i0n ekpOS@n 50 838 1.00 1.00 1.00 1.00 1.00 0<$1U0<n34 36 498 1.04 (, 0.63- 1.72) 0.94 ( 0.55• 1.61) 0.90 ( 0.49- 7.64) 0.99 t, 0.60• 7.65) 0.87 ( 0.49- 1.55) 34<S1UD<s42 13 103 1.96 ( 0.94• 4.05) 1.29 { 0.55- 3.03) 1,47 ( 0.60- 3,60) 1.96 ( 0•95• 4.08) 1.36 ( 0.54• 3,41) 42<S1UD 7 80 1.29 ( 0.52- 3.23) 1.10 ( 0.41- 2.90) 0.90 ( 0.31• 2.65) 1.34 ( 0.53- 3.37) 1.14 ( 0.42- 3.10)~ Excludrd/Tn'nal 3~ 23 0.19 0.20 . 1 0.25 ( 0.19 ~ 0.21 SMALL CELL CARCINOMA NOn ikpOSlC al w38 1.00 1.00 1.00 1.00 1. 00 ) O<$1UD<n34 23 498 1.11 ( 0.59• 2.08) 1.10 1 0.57• 2.11) 1.17 ( 0.59- 2.35) 1.09 ( 0.57• 2.06) t . 1 4 i, 0.59- 2.17) 34t$1U0<42 2 103 2.76 ( 1.11- 6.92) 2.51 1 0.95- 6.64) 2.59 ( 0.89• 7.52)1 2.89 ( 1.14- ?.31) 2.83 ( 1.06• 7.55) I 42<S1UD l 6 80 1.55 ( 0.56- 4.26) 1.57 ( 0.56• 4.41) 1.73 ( 0.59• 5.05) 1.56 ( 0.56• 4.33) 1.22 ( 0.47• 3.62) fxBlUdrd/Trrnd 2 23 0.10 0.12 j 0.18 ~ 8.10 0.10 E C.DENOCARCINOMA Nan @kpns@n 159 838 1.00 1.00 1.00 1.00 1.00 Ot$tU0<n34 ! 117 498 1.00 ( 0.74- 1.35) 1.02 ( 0.74- 1.40)1 0.97 ( 0.67- 1.42) 1.03 ( 0.76- 1.39) 1.00 ( 0.71- 1.40) 34<S1UD<42 I 28 103 1.29 { 0.78- 2.13) 1.36 ( 0.80• 2.30)1 1.32 f, 0.73- 2.39)/ 1.35 ( 0.82• 2.23) 1.39 { 0.79- 2.44) 42<S1UD ~ 19 80 1.04 ( 0.58- 1.88) 1.02 ( 0.54• 1.91) 1.11 ( 0.55- 2.23) ( 1.18 ( 0.65• 2.14) 1.02 ( 0.53- 1.95) €xcludediTrrnd l 10 ~ 23 ~ 0.56 0.52 0.63 I 0.56 0.60 OTHER Non @xposen 56 838 1.00 ( 1.00 1.00 1.00 1.00 0<$tU0<•34 I 39 498 1.01 ( 0•63- t.63) 1.11 ( 0.67- 7.84) 1.01 ( 0.56- 1.61) 1.02 ( 0.63- t,66) 1 1.20 ( 0.70- 2.04) 34<StUDer42 13 103 1,77 ( C.87- 3,60) 2.09 ( 1.00- 4.36) 1.97 ( 0.88• a.42) 1.85 ( 0.90• 3.79) 2.34 { 1.05• 5.24) 42<S1U0 ~ 3 80 0.43 ( 0.13- 1.48) 0.47 ( 0.13- 1.62)f 0.33 ( 0.07- 1.46) 0.47 { 0.14. t.62)~ 0.38 ( 0.09• 1.69) ~xcludrd/Trrnd( 4 ~ 23 0.92 ~ 0.93 j 0.96 0.90 ( 0.95 , >75% OF UFESPAN IN RURAL AREA OR INTERMEDIATE CITIES Non @xpostn 122 1.00 1.00 1.00 1.00 1•00 0<StUD<34 1.04 ( 0.70- 1.54) 1.04 ( 0.70- 1.54) 0.80 ( 0.51- 1.26)i 1.02 ( 0.68- 5.57) 0.92 ( 0.61- 1.39) 34<SSUD<42 2.57 ( 1,37• 4,80) 2.57 { 1.37- 4.80) 2.90 ( 1.42- 5•94) 2.61 ( 1,39- 4-90) 2.13 ( 1.10- 4.12) d2<S1UD 1.15 ( 0.54• 2.44) 1.15 ( 0.54- 2.44) 0.92 { 0.41- 2.09) 1.17 ( 0.55- 2.50}I 1.07 ( 0.49- 2•341 Exc1 udr d/TrMd 0.06 0.06 0.12 0.07 €1 0.07 >75% OF LIFESPAN IN URBAN AREA Non @%pOt@C 103 356 1.00 7.00 1,00 1.00 1.00 0<S1UD<34 90 238 1.03 ( 0.70- 1.50) 1.03 ( 0.70• 1.50) 1.17 ( 0.76- 1.82) 0.99 ( 0.67- 1.46 ) 1.18 ( 0.76- 1.82) ~ 34<S1UD<42 24 S9 1.16 I , 0.64- 2.10) 1.16 ( 0.64- 2.10) 0.99 ( 0.50- 1.95) 1.19 ( 0.65- 2.16) 1.52 ( 0.75- 3•09) 42<S1UD II 16 46 0.80 ( 0.40- 1.58) 0.80 ( 0.40• 1.58) 0.72 ( 0.33- 1.59) 0.93 ( 0,46- 1.88) 0.72 ( 0.32• 1.61) €xeludrd/Trrnd~ 11 14 0.93 0.93 0.92 0.93 0.92 (1) Model irtcfuda sex, conler, eex'cenferand age (2) Model include sex, Oenter, sex'center, age and proportion of residenGal type in the last 35 yrs (REUP) (3) Model Fndude sex, conter, sex'eenler, age, proportion of residential type in the last 35 yrs (REUP) and educational level (EDUC) (4) Model hrcWde sex, cente~, sex•center, age and duratton orexposure to Ast A agents (OCCAY) (5) Model Include @ex, conter, sexbenter, age and frequency consumption of vegetables (VEGE) OR{~) 957. CS OR 2 957. Cl 1.00 1,00 1.53 ( 0.82- 2.85) 1.63 ( 0•83- 3.19) 1.43 ( 0.14-14.34) 1.80 ( 0.16-20.57) 0.81 ( 0.07- 8.84) 0.73 ( 0.07- 8.12) 0.30 0.36 376 1•00 439 0•99 ( 0.77- 1.27) 98 1.57 ( 1.06- 2.31) 76 1.05 ( 0,66• 1.68) 22 0.19 8 1.70 (, 1.01- 2.88) 1.79 ( 1.05• 3.07) 5771 1.00 1 1.00 0.99 ( 0.73- 1,34) 1.01 ( 0.74- 1.38) 288 R 3) 95•l. CI OR(4) 95% CI OR(S) 95'. CI 1.00 1.00 1.00 1.35 ( 0.56- 3.27) 1.51 ( 0.81- 2•84) 1.55 ( 0.77- 3.12) 0.00 ( 0.00-99.99) 1.51 ( 0.15-15.26) 2.16 ( 0.17-27.00) 0.00 ( 0.00-99.99) 0.79 ( 0.07- 8.58) 0.85 ( 0.07- 9.78) 0.35 0.30 0.29 1.00 1.00 1.00 0.95 ( 0.70- 1.30) 0.98 ( 0.76- 1.27) 0.97 ( 0.73- 1.29) 1.52 ( 0.96- 2.39) 1.62 ( 1.10- 2.39) 1.55 ( 0.99- 2.44) 0.92 ( 0.53- 1.59) 1.16 ( 0.72- 1.86) 0.86 ( 0.b1• 1•47) 0.26 0.18 0.22 ~ 2063593363 ~ sk estimates- Snnuse-

C ~S1 DH Spouse, Duration (hours/day x years) ALL CsM'ERS Lw.I olexposure ~ Cases ) Contro)s OR(1)_957. CI ~ OR(2) 95% CI Non exposed 297 778 1.00 1.00 0<S1DH<135 165 396 0.90 ( 0.70- 1.16) 0.87 135<S1DH<s223 44 81 1.20 ( 0.78- 1.85) 1.33 ~ 223<S10H 41 1 63 1.80 ( 1.12- 2.90) 1.74 ekeludad/Trend ALL CEMfERS WITH EDUCAT 103 IONAL LEV EL AN 234 D TY 0.02 PE OF RES 1 IDENCE 0.02 Non exposed 0<S1DH<.136 135<S1DHe223 223<SiDH ~rcludad/Trend ALL CENTERS WITH DIETARY DATA 179 111 31 25 152 Non exposed 223 0<S10H<135 128 135<S1DH<223 36 2.23<S10H 23 Excl uded/Trend 99 FRANCE 474 270 50 33 229 100 . 1.00 0.89 ( 0.65- 1.22) 0.89 1 1.28 ( 0.76- 2.15) 1.28 1.48 ( 0.83- ~ 2.63) 1.49 0.26 0.25 1.00 1•00 0.84 ( 0.63- 1.12) 0.83 1.40 ( 0.85- 2.30) 1.53 1.49 ( 0.81- 2.73) 1.57 0.09 ( 0.10 OR(3) 95% Ct OR(5) 95'/. CI 1.00 : 1.00 1.00 ( 0.67- 1.15) 0.87 ( 0.63- 1.ts) 0.91 ( 0.70- 1.18) 0.84 ( 0.63- 1.12) ( 0.84• 2.10) 1.25 ( 0.74- 2.11) 1.31 ( 0.84- 2.02) 1.38 ( 0.84• 2.27) ( 1.03- 2.92) 1.47 ( 0.83- 2.62) 1.84 ( 1.14- 2.97) 1.46 ( 0.80- 2.69) 0.02 0.02 0.02 1.00 1 1.00 1.00 ( 0.65- 1.22) 0.87 ( 0.63- 1.19) 0.90 ( 0.65- 1.24) 0.88 ( 0.62- 1.24) ( 0.76- 2.15) 1.25 ( 0.74- 2.11) 1.37 ( 0.81• 2.33) 1.53 ( 0.86- 2.71) ( 0.84- 2.65) 1.47 ( 0.83- 2.62) 1.50 { 0.84- 2.68) 1.53 ( 0.79- 2.98) 0.29 ( 0.26 0.28 ( i 1.00 € 1.00 1.00 ( 0.62- 1.12) 0.84 ( 0.59- 1.20) 0.85 ( 0.64- 1.14) 0.84 ( 0.63- 1.12) ( 0.91- 2.56) 1.48 { 0.83- 2.63) 1.49 ( 0.90- 2.46) 1.38 ( 0.84- 2.27) ( 0.85- 2.92) 1.50 ( 0.77- 2.92) 1.52 ( 0.83. 2.80) 1.46 ( 0.80- 2.69) 0.13 ~ 0.09 0.11 1 Non axposed 39 65 1.00 1.00 1.00 1.00 1.00 0<S1DH<135 27 64 0.77 ( 0.40- 1.49) 0.60 { 0.28- 1.29) 0.86 ( 0.25• 1.77) 0.74 ( 0.38- 1.45) 0.76 ( 0.39- 1.47) 135<S10H<233 3 13 0.42 ( 0.11- 1.65) 0.36 ( 0.07- 1.85) 0.44 ( 0.05• 4.29) 0.45 ( 0.11• 1.78) 0.41 ( 0.10- 1•60) 223<S10H 2 3 1.32 ( 0.20- 8.69) 1.69 ( 0.25-11.56) 1.39 ( 0.10-18.90) 1.32 ( 0.20- 8.72) 1.33 ( 0.20- 8.78) ExclOdrd/Trondi s s 0.49 0.55 0.55 0.47 p 0.48 GERMANYI OXposotl 1 O<S10H<•135 f 135<$1DH<•223 ~ Non 223<SIDH Excluded/T/Yndl GERMANY2 34 153 1.OD ( 1.00 1.00 1.00 1.00 22 50 1.21 ( 0.59- 2.50) 1.17 ( 0.53• 2.56) 1.12 ( 0.51- 2.46) 1.24 ( 0.19- 2.58) 1.37 ( 0.65- 2.87) 3 6 1.55 ( 0.34- 7.04) 1.67 ( 0.34- 8.07) 1.57 ( 0.31- 7.90) 1.69 ( 0.37- 7.79) 1.65 ( 0.35- 7.66) 2 3 1.58 ( ~ 0.24-10.53) 1.42 ( 0.21- 9.89) 1.12 ( 0.15- 8.34) 1.63 ( 0.24-10.89) 1.51 { 0.22-10.54) f5 17 0.48 0.63 0.77 E 0.48 0.54 Non ®xpOS®0 66 98 1.00 100 . 1.00 1.00 1.00 0<S1DH<•135 39 54 0.75 ( 0.42- 7,34) 0 .71 ~ ( 0.39- 1.28) 0.67 ( 0.37- 1.22) 0.75 ( 0.42- 7.34) 0.73 ( 0.41- 1.31) 135<S10H<•223 14 6 2.43 ( 0.84- 7,07) 2.40 ( 0.82- 7.02) 2.27 ( 0.77- 6.66) 2.42 ( 0.83- 7.02) 2.44 ( 0.84- 7.07) 223<S1DH 6 3 1.93 ( 0.44- b•54)i 1.85 ( 0.41- 8.31)~ 1.70 ( 0.37• 7.74)~ 1.93 ( 0.44• 8.55) 1.93 ( 0.43- 8.53) exclUded/Tfend f7 2 0.10 I 0.11 0.15 0.10 0.10 GERMANY3 Non exROSed 22 35 0<S10H<135 5 131 1.0o 1.00 1.00 1.00 1.00 0.59 ( 0.17- 2,11) 0.68 ( 0.18- 2.63) 0.48 ( 0.12• 1.98) 0.72 1 0.20- 2.65) 0.48 ( 0.13- 1.82) 223<S10H 1.55 ( 0.08-28,58) 1 1 € 99.99 ( 0.00-99.99) 99.99 ( 0.00-99.99j 2.07 ( 0.11-40.84) 1.68 ( 0.09-31.94) 5'zc1 udrd/ rrend 1 ~ i E .?~ 3 0.93 0.34 0.48 0.88 0.94 ITALY I Non exposed 16 123 1.00 1.00 1.00 1. 00 € 0<31DH<13S 1 15 68 0.96 ( 0.40- 2.30) 1.22 { 0.49- 3.02) I 1.06 ( 0.42• 2.67) 1.22 ( 0.48- 3.08 ) €p 1 135<S10H<223 13 0.25 ( 0.03- 2.20) 0.42 ( 0.05• 3.77) 0.38 ( 0.04- 3.47) 0.39 ( 0.04- 3.52 ) 223<s1DH p 3 10 1.07 (, 0.24- 4.75) 1.54 ( 0.33- 7.13)i 1.33 ( 0.29- 6.14) 1.30 ( 0.29- 5.90) E'xclodrd/Trend f 5 -' ` 0.63 ! 0.76 ) 0.77 0.64 ( ITALY 2 Non exposed 0<S1DH<135 135<810H<223 223<S1DH SxcludedlTrend ITALY 3 1061 1.00 1 1.00 1 1.00 0.48 ( 0.13- 1•74) 0.36 { 0.08- 1.53) 0.41 { 0.06. 2.54) 0.37 (• 0.04- 3.49) 0.42 ( 0.04- 4.29) 2.11 ( 0.12•36.74) 1.23 ( 0.20- 7.68) 1.39 ( 0.21- 9.36) 1.57 ( 0.11-22.88) 0.95 0.80 0.95 Non .Xposetl 4 23 1.00 1.00 1.00 1.00 1.00 0<S1DH< 1 35 3 6 5.99 ( 0.57•63.00) 4.62 ( 0.39-54.23) 1.23 ( 0.10-15.82)1 6.19 ( 0.56-68.81) 4.84 { 0.45-51.71) 935<S10H<•223 3 5 2.29 ( 0.30-17,36) 2.26 ( 0.29-77.38) 1.24 ( 0.11-13.48) 2.03 ( 0.25-16.24) 3.51 ( 0.37-33.53) 223<S1DH 3 1 28.32 ( 1.26-99.99) 99.99 (- 0.00•99.99) 99.99 ( 0.00•99.99) 27.73 ( 1.20-99.99) 14.92 ( 0.61•99.99) f Ezcludrd/Trend 3 95j 0.07 0.05 0.07 : 0.09 0.07 PORTUGAL 1 Non expose0 0<S16H<135 135<$10H<223 223<SiDH rxcludrdlTrend PORTUGAL2 Non expoted 0<S10H<.135 135<S1DH<.223 223<S10H 1.00 1.68 { 0.46- 6.18) 0.67 ( 0.12- 3.90) 3.95 ( 0.88-17.71) 0.15 16 38 1.00 1.00 1.00 8 11 3.39 ( 0.85-13.50) 1.31 ( 0.24- 7.04) ~ 2.96 ( 0.72•12.11) 3 1 19.81 ( 1.44-99.99) 18.98 ( 0.88-99.99) 17.73 ( 1.30-99.99) 3 0 99.99 ( 0.00-99.99) 99.99 { 0.00•99.99) 99.99 ( 0.00•99.99) ExelOdad/Trand 31 3 0.01 ~ 0.01 0.01 € I SPAIN Non oxposed 0<S1DN<t35 135<SiDH<223 9! 223<S1DH i Fzcluded/TrendI 23 So 1.00 1.00 1.00 1.00 1.00 12 37 0.67 ( 0.23- 1.60) 0.67 ( 0.27- 1.67 ) 0.67 ( 0.26- 1.74) ~ 0.69 ( 0.29- 1.67) 0.67 1 0.28- 1•62) 9 20 0,96 f, 0.36• 2.50) ( 1.14 0.40- 3.26) 1.01 ( 0.34- 3•03) 1.06 ( 0.36- 2.93) 0.98 ( 0.36- 2.66) 8 21 0.94 ( 0.33• 2.65) 1.00 ( 0.34- 2.95) 0.99 ( 0.33- 2.95) 0.93 ( 0.33- 2.63) ~ 0.90 ( 0.32• 2•55) 19 31 0.89 0.94 ( 0.92 ~ 0.91 0.95 S'r~'EDEN a%pOSed Non 0<S1DH<•135 135<SiDH<223 223<S1DH 38 62 1.00 1.00 1.00 1.00 21 47 0.81 ( 0.41- 1.61) 0.81 ( 0.41• 1.63) ~ 0.82 ( 0.41- 1.64) 0.83 ( 0.42- 1.66) 4 2 3.28 ( 0.55•19.60) 3.16 ( 0.52-19.21)~ 3.46 ( 0.58-20.69) 3.14 ( 0.52-18.95) 2! ~ 1 3.29 ( 0.27-39.76) 3.43 ( 0.27•43.06) ~ 3.42 ( 0•28-41•07) 3.60 ( 0.30-43.30) fzcludrd/Trend 5~ 0 0.21 j 0.21 t j 0.18 ~ 0.19 UNITED K1NGD0M 2063593366 Zxcluded/Trond 26 (1) Model indude sex, center, sex'center and age (2) Model include sex, center, sex'cOnter, age and proportton of residenUat type in the last 35 yrs (REUP) (3) Mode) Includ4 sex, center, sex'center, age, proportion of residential type in the last 35 yrs (REUP) and educaUonal level (EDUC) j4) 41oda( (nc(ude sex, center, sex-center, age and duration of exposure to list A agents (OCLAY) (5) Mode1 tnciude sac, center, sex'center, age and frequency ansumpt on of vegetables (VEGE) ; Risk estimates - Spouse

CIUD Childhood 0-98 yrs, Duration (years) (non ovedapping) MEN ONLY Tot31 E Exposed Unexoosed Exduded ~ Min P10 01 ~ Median 03 1 P90 Max ~ Mean j Std MOn Ca6CS 157 76 80 0.50 6.00 10.25 12.00 18.00 18.50 18.50 12.64 5.12 Controls 580 335 236 9 0.50 5.00 10.50 16.00 18.50 18.50 18.50 13.62 5.33 Ai! 737 411 316 10 0.50 5.50 10.50 15.00 ~ 18.50 18.50 18.50 13.44 5.30 WottSCn CdSSs 0 0 0 0 calUols 0 0 0 ~ 0 All 0 0 0 0 AA ~ 157 76 80 ; 0.50 6.00 10.25 12.00 18.00 18.50 18.50 12.64 5.12 Controls 580 335 236 9 0.50 5.00 10.50 ~ 16.00 18.50 18.50 18.50 13.62 5.33 All 737 411 316 10 0.50 5.50 10.50 15.00 18.50 18.S0 18.50 13.44 5.30 WOMEN ONLY Mcn CBSd 0 0 0 0 Controls 0 0 0 0 , i All 0 0 0 0 ~ ~ - WOn1Cn CeSC3 550 344 198 8 0.50 6.00 10.501 16.00 18.50 18.50 18.50 13.76 5.20 Controls 1076 '16i 344 16 0.50 6.00 10.50 17.00 18.50 18.50 ~ 18.50 14.27 5.20 All 1626 1060 542 24 0.50 6.00 10,50~ 17.00 18.50 18.50 18.50 14.10 5.20 AII CisCS 550 344 198 8 0.50 6.00 10.50 16.00 18.50 18.50 18.50 13.76 5.20 Control9 1076 716 344 16 0.50 6.00 10.50 17.00 18.50 18.50 18.50 14.27 5.20 All 1626 10601 542 24 0.50 6.00 10.50 17.001 18.50~ 18.50 18.50 14.10 5.20 POPULA7ION BASED STUDIES Men Cr1sOS 31 55 35 1 0.50 3.00 8.50 10. 50 95.00 18.50 18.50 11.30 5.06 Controls 444 266 169 9 0.50 ! 5.00 10.00~ 12.00 18.50 18.501 18.50 12.95 5.39 All S35 321 204 10 0.501 5.00 10.00 11.00 18.50 18.50 18.50 12.67 5.36 Won1Cn Cisef 287 165 117 5 0.50 5.00 9.00 10.50 18.00 18.50 18.50 11.54 5.05 Controls 506 340 157 9 0.50 5.00 10.00 10.50 18.50 18.50 18.50 12.74 5.33 !41 793 S0S 274 14 0.50 5.00 10.001 10.50 18.50 18.50 18.50 12.35 5.27- Ap C25CS 378 220 152 6 0.50 5.00 9.00 10.50 17.50 18.50 18.50 11.48 5.04 Contra8 950 606 326 18 0.50 5.00 10.00 11.00 18.50~ 18.50 18.50 12.83 5.35 All 1328 826 478 24 0.50 5.00 10.00 10.50 18.50~ 18.50 18.50 12.47 5.30 HOSPITAL ®ASED STUDIES Man Csses 47 18 29 0 7.00 10.00 14.00 17.00 18.50 18.50 18.50 15.83 3.54 Controls 73 45 28 0 5.00 11.00 16.00 18.50 18.50 18.50 18.50 16.42 3.73 Al) ~ 120 63 57 0 5.00 11.00 16.00 18.50 18.50 18.50 18.50 16.25 3.65 Women G85ef 199 132 64 3 0.50 7.50 13.00 EEE 18.50 18.50 18.50 18.50 15.30 4.84 Controls 379 271 101 7 0.50 8.00 13.50 ~ 18.50 18.50 18.501 18.50 15.69 4.69 All 578 403 165 10 0.50 8.00 13.00 18.50 18.50 18.50f 18.50 15.56 4.74 All Cases 246 150 93 3 0.50 7.75 13.00 18.50 18.50 ?8.50 18.50 15.37 4.69 Controls 452 ~ $16 129 7 L 0.50 8.50 14.00 18.50 t8.50 48.50 18.50 95.791 4.57 898 All 466 222 10 0.501 8.00 13.50 18.50 18.50 18.50 18.50 15.65 4.61 WITHOUT OCCASIONAL SMOKERS M@n aSts ! 112 05 56 Controls 406 228 173 i 1 0.50 3.00 10.00 18.00 10.50 18.50 18.50 11.97 5.28 5 0.50 5.00 10.50 1 13.75 18.50 18.50 18.50 13.28 5.40 All 518 283 229 6 0.50 5.00 10.50 12.50 18.50 ?8.50! 18.50 13.03 5.40 Wom011 GSC3 430 275 150 6 0.50 7.00 10.50 15.00 18.50 18.50 18.50 13.70 5.10 Controls 810 525 273 12 0.50 5.00 10.50~ 17.00 18.50 18.50 18.50 14.01 5.25 All 1240 800 423 17 0.50 6.00 10.50 17.00 18.50 18.50 18.50 13.90 5.20 Att C8SC3 542 /E conuaf 1216 All 758 330 "53 1083 206 446 652 6 17 23 0.50 0.50 0.50 6.00 5.00 6.00 10.50 10.50 10.50 14.00 18.50 17.00 18.50 16.00 18.50 ';8.50 18.50 18.50! 18.50 18.501 18.50 13.41 13.79 13.67 5.16 5.31 5.25 Men CmsCf $7 31 26 0 1,00 8.50 10.00 10.501 16.00 18.50 18.50 11.66 4.79 Controls ~ 172 100 72 0 0.50 6.25 10.50 16.001 18.501 18.50 18.50 13.76 5.21 ~ Rll 229 , 131 98 1 0 0,50 6.50~ 10.50 14.00 18.501 18.50 18.50 13.27 5.17 Won1IN1 Cm56f 13 8 82 55 11, 0.50 9.50 10.50 18.00 18.50 18.50 18.50 ' 14.92 4.75 COnV01s 254 1 159 91 4~ 0,50 6.50 10.50 18.00 18.50 18.50 18.50' 14.30 5.04 All 392 241 1461 5 0.50 8.00 10.50 18.00 18.50 18.50 18.50 14.51 4.94 All CBSOS 195 i13 81 0,50 8.50 10.50 16.00 98.50 18.50 18.50 14.03 4.96 Controls 426 259 163 4 0,50 6.50, 10.50 17.00 18.50 18.50 18.50 14.09 5.10 All 621 372 244 5 0,501 7.00 10.50 17.00 ~ 18.50 18.50 18.50 14.07 5.05 AGE 55-E4 YEARS Men CasC3 52 25 26 1 2.50 6.00 8.00 10.50~ 18.00 18.50~ 1 8.50 12.22 5.?8 Controls 216 118 92 6 0.50 5.00 10.50 12.00 18.50 18.50 18.50 12.92 5.33 All 288 143 118 0.50 5.00 10.00 12.00 18.50 18.50 18.50 12.80 5.29 Womcn Cas es 176 115 58 3 0.50 5.00 10.50 13.00 18.50 18.50 18.50 13.14 5.31 Controls 359 250 102 7 0.50 4.00 10.00 17.00 18.50 18.50~ 18.50 13.60 5.7E All 535 385 160 10 0.50j 4.00 10.50 17.00 18.501 18.50 18.50 13.45 5.64 All Cases 228 140 84 4 0.50 5.00 10.50 12.75 18.50/ 18.50 18.50~ 12.98 5.2E Controls 575 368 194 13 0.50 4.00 10.00 17.00 18.50 18.50 18.50 13.38 5.64 All 803 508 278 17 0.50 4.50 10.00 15.00 18.50 18.50 18.50 13.27 5.54 AGE 65+ YEARS Men C99es Controls ~ A1) 48 192 240 20 117 137 28 72 100 0 3 3 0,50 0.50 0.50 7.00 5.00 5.00 12.00 10.50 10.50 17.00 18.00 18.00 18.50f 18.50if 18.50 18.50 18.50 18.50 18.50 14.70 18.50 14.20 18.50 14.27 5.22 5.4C 5.3E Women Cases 236 147 85 4 0.50 8.00 10.50 15.00 18.50 18.50 18.50 13.59 5.2E Controls 463 307 151 5 2.00 8.00 10.50 18.00 18.50 18.50 18.50i 14.79 4.70 All 699 454 236 9 0.50 7.00 10.50 17.00 __18.50 !_18.50 18.50I 14.40 4_.92 Atl C35Cf 284 167 113 4 0.50 6.00 10.50 _ 16.00 18.50 18.50 18.50 13.73 5.2, Controls 655 424 223 8 0.50 8.00 10.50 18.00 18.50 18.50 18.50 14.63 4.92 All 939 591 336 12 0.50 7.00 10.50 17.501 18.50 18.50 18.501 14.37 5.0: 2063593351 Descriptive statistics - Childhood 0-18 years

FJ_11>IHV Spouse, Average exposure (cigarettes/day) dLL CENT€R3 1-Wl1 Of U(ppsUT! Cases Contrpts OR111 95X CI OR(2) 95% Cl (_ OR(3) 957S.C1 ( OR(4) 95% C( OR(5) 95% Cl NE,, S1AV<10 10<S1AV<18 1a<S1AV ExcludO/Trondi ALI. CENTERS WITH EDUCA710NAL 503 25 35~ 87( LEV 1189 83 55 2151 EL AND TY 1.00 0.55 ( 1.30 ( 0.82 PE OF RES 0.34- 0.82- IDENC 0.89) 2.06) E 1.00 0.51 ( 1.25 ( 1.00 0.30- 0.85) 0.49 ( 0.78- 2.01)1 1.36 ( 0.28- 0.78• 0.88) 2.37) 1.00 0.55 ( 1.32 ( 0.82 0.34- 0.89) 0.83- 2.08)~ 1.00 1 0.48 ( 1.13 ( 0.83 0,28- 0.66- 0.82) 1.94) HE., S1AV<10 314 854 1.00 1 1.00 ! 1.00 1.00 1.00 10<51AV<18 17 651 0.49 ( 0.28- 0.87) 0.49 ( 0.28- 0.87)~ 0.49 ( 0.28- 0.88) 0.50 ( 0.28- 0.88) 0.51 ( 0.28- 0.93) 18<S1AV 24 38 1.34 ( 0.77- 2.33) 1.34 ( 0.77- 2.33) 1.36 ( 0.78- 2.37) 1.36 ( 0.78- 2.37) 1.37 ( 0.75- 2.53) Excludad/Trend1 ALL CENTERS VY1TH DIETARY DATA 143 1 3 81 0.28 0.28 0.170 0.28 0.29 ~ HE., 51AV<•10 381 739 1.00 1.00 1.00 1.00 1.00 10<S1AV<•18 20 68 0,49 ( 0.29- 0.84) 0.53 ( 0.31- 0.91) 0.52 (- 0.28- 0.94) 0.50 ( 0.29- 0.84) 0.48 ( 0.28- 0.82) 1a<s1A 25 V 40 1.11 ( 0.65- 1.89) 1.17 (, 0.68- 2.01) 1.41 ( 0.76- 2 60) 1.12 ( 0.66- 1.91) 1.13 ( 0.66- 1.94) 1 € 1 / r'xc uded Trend 83 2091 0.28 0.28 0.31 0.28 ~ 0.28 FRANCE NE., S1AV<10 10<S1AV<•18 18<S1AV BS 118 1.00 1.00 1.00 1.00 1.00 3 i3 0.43 ( 0.12- 1.57) 0.50 ( 0.13- 1.91)~ 0.54 ( 0.10- 2.95) 0.43 ( 0.12- 1.59) 0.42 ( 0.11- 1.54) ~ 5 17 0.54 ( 0.19- 1.66) 0.60 ( 0.20- 1.83) 0.90 ( 0.23- 3.44) 0•53 ( 0.18- 1.55) 0.56 ( 0.19- 1.62) €xcluded/Trond 4 31 0.13 i 1 0.15 ~ 0.16 ~ 0.13 ~ 0.14 GERMANYI NE., 51AV<•10 10<S1AV<1S 18<S1AV 56 202 1.00 1.00 1.00 1.00 ! 1•00 ) 5 11 1.27 ( 0.40- 4.09) 1.49 ( 0.44- 5.08)~ 1.50 ( 0.44- 5.15) _ 1.39 ( 0.42- 4.56) 1•32 ( 0.41- 4.27) 3 6 0.85 ( 0.20- 3.66) 0.83 ( 0.19- 3.66) 0.85 ( 0.18- 3.98) ~ 0.87 ( 0.20- 3.75) 0.88 ( 0•20- 3.80) ~ Exc1 ad~d/Trtnd 121 10 0.97 0.94 ~ ~ 0.95 €€€ 0.95 ~ 0.92 GERMANY2 N ., ~u1AV<10 10<S1AV<•18 18<S1AV 118 141 1.00 1.00 1.00 1.00 1.00 5 14 0.29 ( 0.10- 0.86) 0.31 ( 0.10- 0.91) 0.30 ( 0.10- 0.91) 0.29 ( 0.10- 0.86) 0.30 { 0,10- 0.88) 5 6 0.72 ( 0.21- 2 49) 0.75 { 0.21- 2.64)1 0.80 ( 0.22- 2.85) 0.71 ( 0.21- 2.48) 0.72 ( 0•21• 2.51) ~cluded/Trand l 14 2 10 0 . 0.11 € 0. 73 t 0.!0 0• 10 ~ GERMANY 3 NE., S1AV<10 10<S1AV<18 18<S1AV 29 50 1.00 1.00 t.00 1.00 1.00 0 1 0.00 ( 0.00•99•99) 0.00 ( 0.00-99.99)I 0.00 ( 0.00•99.99)1 0.00 ( 0.00-99.99) 0.00 ( 0.00-99.99) 1 0 99.99 ( 0.00-99.99) 99.99 ( 0.00•99.99)It99.99 ( 0.00-99.99) 99.99 j 0.00-99.99) 99.99 ( 0.00-99.99 ) r"xcl uded/Trand 1 0.38 0.37 ~ 0.55 0.39 0.39 TALY I NE,, S1AV<10 33 192 1.00 1.00 - 1.00 1.00 10<S1AV<tfl 10 0.41 (, 0.05- 3.56) 0.50 ( 0.06- 4.35) 0.46 ( 0.05- 4.01) 0,45 ( 0.05- 3.86) 18<SIAV 2~ 6 1.40 ( 0.25• 7.86) 1.64 ( 0.29- 9.29) 1.58 ( 0.28- 9.03) 1.50 ( 0.27- 8.38 ( ) t Excludfd/Trand 41 13 0.94 0,96 ~ 0.96 0.93 i ITALY 2 NE,, S1AV<•10 10<S1AV<18 18<S1AV 16 158 1.00 1.00 1.00 1.00 0 4 0.00 ( 0•00-99.99) 0.00 ( 0.00-99.99) 0.00 ( 0.00-99.99) 0.00 ( 0.00•99.99) ~ 2 6 2.20 ( 0.37•12•90)1 3.30 ( 0.52-20.92) 2.92 ( 0.19-44.88) 1.88 ( 0.31-11.20) ~ r'xcluded/Tr.nd~ 1 ~ 5 0.57 ~ 0.32 0.44 f 0.69 ~ j ITALY 3 HE., S1AV< [ •10 12 34 1.00 i 1.00 t 1.00 : 1.00 i 1.00 t0eS1AV<•18 1 1 5 0 0.38 ( 0.04- 3.83) .39 ( 0.04- 4.16)I 0.26 { 0.02- 4.07) 0.17 { 0.01- 3.37) 0.31 ( 0.03- 3.38) 18<S1AV l 1 1 2.66 ( 0.11-67.13) 99.99 ( 0.00•99.99)~99.99 ( 0.00•99.99) 2.30 ( 0.09-57.72) 99.99 ( 0.00-99.99) Excluded/Trend 2 11 0.88 1 0.89 ! 0.75 0.68 0.86 PORTUGAL 1 HE,, 31AV <t0 41 7( 1.00 1.00 10<SiAV<18 ~ 4 114,91 ( 0.49-49.16) 4.83 ( 0.49-47.84) 18<S1AV 3~ 0 99.99 ( 0.00-99.99) 199.99 ( 0.00•99.99) ~xcludsd/ Trend 1~ C•05 ~ 1 0.05 PORTUGAL2 NE., 51AV<i0 27 48 1.00 t 1.00 1.00 18<S1AV 3 2 2.91 ( 0,43-19,78) 3.14 ( 0.41•24.24) ~ 2.98 ( 0.44•20.10) i ExclUded/Trend ~ 3 3 0.27 0.17 ~ 0.28 ~ ~ SPAIN NE., S1AV<10 10<S1AV<18 1a<S1AV 44 10 8 1.00 1.0o 1.00 1 00 o 1.00 3 16 0.47 ( 0•13- i,72) 0.48 ( 0.13- 5.77) 0.52 ( 0.14- 1.97) 0.47 ( 0.13- 1.73) 0.49 ( 0.13- 1.80) ~ 1 ? 8 2.33 ( 0.77- 7.04) 2.51 ( 0.80- 7.93) 2.64 ( 0.83- 8.38) 2.29 ( 0.76- 6.91) 2.55 ( 0.83• 7.84) $xc1 udad/Trand 17~ 27 0.45 ~ 0.50 ~ 0.45 0.43 ~ 0.37 ~ SHI€DEN NE., 51AV<10 10<S1AV<•18 18<S1AV 62 101 1.00 1.00 1.00 1.00 3 8 0.58 ( 0.14- 2.33) 0.62 ( 0.15- 2.52) 0.61 ( 0.15• 2.43) 0.53 ( 0.13- 2.15) 3 3 2.07 ( 0•39•11•07)1 2.06 ( 0•38-11.30)i i 2.06 ( 0.38-11.05) 2.22 ( 0.40•12.29j E'xc1 udf d/Trond 2 0 0.83 ~ 0.79 ~ i 0.81 0.86 ~ UNITED KlNGDOM (1) Modet tnctude sex, center, sex'center and age - (2) Modei include sex, center, sex'center, age and proportfon of residential type in the last 35 yrs (REUP) (3) Model Include stx, caltor, sex'center, age, propo(tion of residential type in the last 35 yrs (REUP) and educattonat level (EDUC) (4) Modet Incfude sex, center, sex'eenter, age and duration of exposure to list A agents (OCLAY) (5) Model include sex, center, sex'cenler, age and frequency consumption of vegetables (VEGE) Risk estimates - Spouse

S1 CU Spouse, Cumulative exposure (packs/day x years) ITALY 2 I 7otal I Fxposed Unexoosed Excluded Min g A10 C1 Median 03 j P90 Max ! Mean E Std ~ MGn Cssef 3 0 3 0 f Controls 97 15 82 0 0.54 0.70 1.29 2.80 8.10 16.00 16.71 5.11 5.35 All 100 15 85 0 0.54 0.70 1.29 2.80 8.10 16.00 16.71 5.11 5.35 WM10n CSSGf 15 8 7 1 ~ 0.20 0.20 2.27 5.70' 24.59 68.00 ~ 68.00 16.66 24.20 Controls 76 47 1 24 5 0.04 1.00 2.96 6.43 12.14~ 29.00 50.14 10.17 11.39 All 92 55 31 6 0.04 1.00 2.96 _ 6.43! 12.14 34.71 68.00~ 11.11 13.85 AII CaSCf 1fl 8 10 1 0.20 0.20 2.27 5.70 24.59 68.00 68.00 16.66 24.20 Controls 173 62 106 5 0.04 1.00 2.10 5.22 11.39 17.00 50.14 8.95 10.45 AN 192 70 116 6 0.04 0.95 2.10. 5.22 11.391 27.04 68.00 9.83 12.73 MGn Ciscs 1 1 9 0 1.89 1.89 1.891 1.89 1.891 1.89 1.89 1.89 0.00 Controls 12 1 2 10 0 1 0.13 0.13 0.13~ 0.77 1.40~ ?.40 1.401 0.77 0.90 All 13 3 10 0 0.13 0.13 0.13 1.40 1.89 1.89 1.89 1.14 0.91 WOnGn C35Cf 15 9 4 2 4.11 6.00 9.43i 4.11 14.00 62.00 62.00 15.32 18.02 Controls 38 15 131 10 0.08 ~ 5.57 10.58 15.50I 18.75 25.00 39.00 15.68 8.98 All 53 24 17 12 0.08 4.35 7.62 14.25 17.18 25.00 62.00 15.54 12.73 AtI CisCf 16 10 4 2 1.89 3.00 4.35 8.96 14.00 38.86 62.00 13.97 17.51 CCnVolf 50 17 23 10 0.08 0.13 6.75 14.86 18.29 25.00 39.00 13.93 9.75 All 66 27 27 12 0.08 1.40 5.57 13.75 16.07 25.00 62.00 13.94 12.83 MGn CiSG3 16 3 13 0 0.10 0.10 0.10 7.50 7.89 7.89 7.89 5.17 4.39 Controls 8 0 8 0 Atl 24 3 21 0 0.10 0.10 0.10 7.50 7.89i 7.89 7.89 5.17 4.39 Women C9sCf 33 16 :6 1.03 1.14 7.88 18.13 24.43 39.00 40.96 17.48 12.08 ContrClf 31 13 171 1 0.14 1.96 2.14 5.26 8.91 14.00 16.57 6.41 5.10 A11 64 29 33 2 0.14 1.14 3.34 8.91 18.51 27.68 40.96 12.52 10.99 All C8SC3 491 19 9 1 0.10 1.03 7.39 14.46 23.79 39.00 40.96 15.53 12.04 Contr0ls 39I 13 25 11 0.14I 1.96 2.14 5.26 8.91 14.0 0 16.57 6.41 5.10 AIl 88i 32 54 21 0.10i 1.141 3.09 8.25 18.13 ..25.0 71 40.96 11.83 10.72 Men Cases 10 0 101 0 I ~ j Controls 17 0 17( 0~ 1 I AU 27 0 27 01 t Women CisOf I 23 14 6 3 0.15 0.64 4.75 9.92 15.32 55.29 75.43 16.43 21.82 Controls 36 12 21 3 0.44 0.96 1.34 3.18 7.73 12.30 33.50 6.53 9.22 All 5D 26 27 6 0.15 0.64 1.70 5.95 13.50 33.50 :75.43 11.86 17.62 AfI Ta SC3 33 14 16 3 0.15 0.64 4.75 9.92 15.32 55.29 75.43 16.43 21.82 Controls 531 12 38 3 0.44 0.96 1.34 3.18 7.73 12.30 33.50 6.53 9.22 All 861 26 54 6 0.15 0.64 1.70 5.95 13.50 33.501 75.43 11.86 17.62 MCn Cases I 6 1 5 0 4.65 4.65 4.65 4.65I 4.65 4.65 I 4.65 4.651 0.00 Contro7s 13~ 0 131 0 ~ I ; / I All 19 1 18 0 6 4.651 4.65 4.651 4.65 4.65 I 4.65 4.65 4.65 0.00 Wom€n CasC3 65 30 f8 17 0.10~ 0.91 2.83 7.88 24.56 35.23 48.30 13.99/ 14.63 I Controls 146, 82 37 27 0.13 1.41 4.55 9.45 17.36 29.571 56.141 13.22 12.33 All 2111 112 55 44 0.10 1.29 3.65 8.96 19.26 30.741 56.14 13.43 12.92 All Ci5@f 71 31 23 17 0.10 0.93 2.83 50 24.56 34.111 48.30 i3.69 14.48 Controls ~ 159 82 S0 27~ 0.13 1.41 4.5S 9.45 17.36 29.571 56.14 13.22 12.33 A11 230 113 731 44 0.10 1.29 i 3.70 8.79 19.23 30.74 56.14 13.35 12.89 ~MCn 111 CasG3 €, 23 Controls ~ 36 Ah 59~ 8 15 9 27 '7I 42 0 0 0 0.201 0.36 0.20 0.20 0.36 0.31 0.32 1.00 0.39 2.80 2.29 2.40 8.27 2 $0 3.49 14.23 9.50 9.79 14.23 9.50 14.23 4.65 2.57 3.55 5.17 2.80 4.09 n1Gn C9s06 47 ~22~ 23 2 0.01 0.55 1.40 6.26 13.54 24.86 37.53 9.56 10.87 Controls 76 411 35 0 0.02 0.07 1.86 5.74 8.36 12.51~ 26.60 6.32 5.90 A11 123 € 631 58 2 0.01 0.35 1.40 5.74 10.00 14.791 37.531 '.45 8.06 AH CaSG3 70 30 38 2 0.01 0.32 1.31 4.30 13.00 19.82 37.53 . 8.25 9.85 Controls ~ 112 50 62 0 0.02 0.21 1.00 4.631 8.00 12.02 26.60I 5.64 5.64 All 182 801 100 2 0.01 0.32 1.13 4.571 9.42 , 14.02 37.53 6.62 7.541 MGn C9;C3 3 0 0 3 Controls: i 4 0 4 14 AH :7 ® 0 0 17 : women Cases 23 0 0 23 Controls 126 0 0 126 ~ All ~ 149 0~ 0~ 149~ ~ All Cises 26 0t 01 ~ 261 ~ 0 Controls 140 01 01 1401 rT - All I _ 166 01 , 01 1661 f~

CIUD Childhood 0-98 yrs, Duration (years) (non overiapping) F Total I Ecposed Urexposed Exduded Min P10 01 { Median 1 03 [ P90 ( Max Mean % Std MCn Cisos 152 74 77 1 0.50 6.00 10.00 10.75 ?8.00 18.50 / 18.50 12.52 5.13 GontraS 580 335 236~ 9 0.50 5.00 10.50 ?6.00 18.50 18.50i 18.50 13.62 5.33 All 732 409 313 10 0.50 5.00 . 10.50 14.50 18.50 38.50 18.50 !!! 13.42 5.31 WOmCn CasCs 531 333 190 8 0.50 6.00 10.SD 16.00 18.50 18.50 18.50 13.68 5.21 Controls 1076 716 344p 16 0.50 6.00 10.50 17.00 1 18.50 18.50 18.50 ~ 14.27 5.20 All 1607 1049 534 24 0.50 6.00 10.50 ':7.00 % 18.50 18.50 18.50 14.08~ 5.21 AA C956s 883 407 267 9 0.50 6.00 10.50 14.50 18.50 18.50 18.50 13.47 5.21 COntfaS 1056, 1051 580 25 0.50 6.00 10.50 17.00 18.50 18.50 18.50 14.06 5.25 All 2339 1458 847 34 0.50 6.00 10.50 17.00 18.50 18.50 18.50 13.90 5.24 sOUAMOUS CELL CARCINOMA MCn Cascs 28 4 24 0 7.00 7.00 8.75 10.50 14.501 18.50 18.50 11.62 4.87 Control5 580 335 236 9 0.50% 5.00 10.50 16.00 ~ ~ 18.50 18.50, 18.50 13.62 5.33 A41 808 339 260 9 0.50 5.00 10.50 16.00 18.50 18.501 18.50 13.60 5.32 Wanrn Cas@3 97 59 37 1 4.00 8.00 10.50 16.00 18.50 18.50 18.50 14.31 4.43 ' `- conuaa 1076 716 344 16 0.50 6.00 10.50 '7.00 18.50 18.501 18.50 14.27 5.20~ 1173 .'-75 381 17 0.50 6.00 10.50 17.00 18.50 18.50 18.50 14.27 5.14 a ~ 14.1 Controls 1~~6 1 1~ E~0 25 0.50 so 6 00 1o so 16 00 o~ 14.06 1 1a 1s a~ ? ! s 2 5 I All 1. 0 . . . , . E. o . 1 Me n n C35CS 14 0 2.50 2.50 10.00 10.50 10.50 18.00 18.00 10.36~ 4.481 ConlrOlf 1 580 335 236 9 0.50 5.00 10.50 16.00 18.50 18.50 18.50 13.62 5.331 Al 594 342 243 9 0.50 5.00 10.501 15.00 18.50 18.50 18.50 13.55 5.331 Women C85e3 67 42 24 1 1.00 7.00 10.50 16.00 18.50 18.50 18.50 13.70 5.11 COntr0lf 10761 716~ 344 16_ 0.50 6.00 10.50 17.00 18.50 18.50 18.50 14.27 5.20 Ail 1143 756 368 17% 0.50 6.00 10.50 ':7.00 18.50 18.50 18.50 14.23 5.20 AI) Cas@S 81 49 31 1 '.00 6.00 10.50 12.00! 18.50 18.50 18.50 13.22 5.12 COntfas 1656 1051 580 25 0.50 6.00 10.50 17.00I 18.50 18.50 18.50 14.06~ 5.25 Ail 1737 ?100 511 26 0.50 6.00 10.50 17.00f 18.50 18.50, 18.50 14.02 5.24 ADENOCARCINOMA Men Cisef 80 44 35 ? 0.50 6.00 10.00 12.001 18.50 18.50 18.50 12.48 5.12 Contras I 580 335 236 9 0.50 5.00 10.50I 16.00% 18.50~ 18.50 1 18.50 13.62 5.33 Ail ! 660 379 271 10 0.50 5.00 10.50 15.00 18.50 18.50 18.50 13.49 5.31 WCiTFCn COSCS 261 176 101 4 0.50 5.00 10.00 /4.25 18.50 18.50 18.50 13.34 5.45 Controls 1076 716 344 16 0.50 5.00 10.50~ 17.00 18.50~ 18.50 I 18.50 14.27 5.20 All 1357 892 445 20~ 0.50 6.00 10.50f 17.00 18.50 18.50 18.50 14.08 5.26 Alt COSCf 361 220 i36 5 0.50 5.50 10.o0t 14.00 18.50 18.50 18.50 13.17 5.39 Controls 1856 1051 580 25 0.50 '.00 70.501 17.001 18.50 18.50 18.50 14.06 5.25 AIt t 2017 1271 716 30 0.501 6.00 10.50 17.00 18.50 ',8.50 18.50 13.90 5.28 OTHER M511 C~1sef 30 19 ?1 01 1.00 2.00 10.501, 16.00 18.00 18.50 18.50 13.60 5.50 Con«ols 5801 335 235 9 0.50 5.00 10.50! 16.00 t8.50 ~ 18.50 18.50 13.62 5.33 A!I 610 354 247 9 0.50 5.00 10.501 16.00 18.50 18.50 18.50 13.62 5.33 Women ~ f~ Cisef ~ 861 06 ti8 2 0.50 7.00 10.25 18.00 18.50 18.50 18.50 14.10 5.31 Conlfas ~ 1078I 'is 344 16 0.50 6.00 10.50 1 7.00 18.50 18.50 18.50 14.27) 5.20 All 1162f 772 372 18 0.50 6.00 10.50 17.00 18.50 18.50 18.50 14.25 5.21 All Cas@f 116 75 39 2 0.50 7.00 10.50 7.00 18.50 18.50 18.50 13.97 5.33 I Controls 1656 1051 580 251 0.50 6.00 10.50 17.00~ 18.50 18.50 18.50 14.06 5.25 All 1772 1126 619 271 0.50 6.00 10.50 17.00 18.50 18.50 18.50 94.05 5.25 a76'h OF LIFESPAN IN RURAL AREA OR INTERMEDIATE CITIES Men C33@S COnUOIS Ail 76 225 301 30 120 150 45 103 148 1 2 3 0.50 7.50 0.501 5.00 0.50 5.00l 8.50 1 10.50 10.50 10.50 14.00 11.00 18.50 10.50 18.50 18.25 18.50 11.52 4.43 18.501 18.50% ?2.97 5.33 /8.50 18.50 12.681 5.18 Women Cases 237 140 94 3 ',.00 8.00 10.50 16.00 18.50 18.50 18.50 14.00 4.5s Contfds 462 290 169 3 0.50~ 6.00 10.50 17.00 18.50 18.50i 18.50~ 13.83 5.22 AII 699 430 263 6 0.501 6.00 10.50 17.00 18.50 18.50 18.5013.89 5.01 AIl CasC3 313 170 139 4 0.50 8.00 10.50 13.50 t8.50 18.501 18.50 /3.56 4.63 ConUOIf ~ 6B7 410 272 5 0.50 5.00 10.50 16.50% 18.50 . 18.50 18.50 13.58 5.26 ~ 1 AII 1000 580 411 9 0.50 6.00 10.50 t5.00~ 18.50 1 18.50 18.50 ?3.58% 5.08 >75% OF LIFESPAN IN URBAN AREA MCn CasCS 48 33 15 Controls 257 ss ss al 305 i6s °11 0 2.00 5.00 10.50 15.00 18.50 18.50 18.50 13.30 5.20 ~ 6% 0.50 5.00 90.50 18.00 18.50 18.50% 18.50 14.10 5.44 6% 0.50 5.00 10.50 17.00 18.50 18.50% 18.50 13.96 5.39 Women C25Cs 1961 137 SS 4 0.50 4.50 10.00 14.00 18.50 18.50 18.50 13.14 5.64 ~ Con«af I 454 326 % 1t9 9 0.50 7.50 10.50 18.25 18.50 18.50 18.50% 14.95 4.90 ; Ail 650 4631 ?74 ?3 0.50 6.00 10.50 18.00 18.50 18.50 18.501 14.41 5.19 AII CeSCf 244% '70 ?0 4 0.50 4.751 10.00 14.25 18.50 18.50 18.50 13.17 5.54 COntfas 711 481 215 15 0.50 6.501 10.50 18.00 18.50 18.50) 18.50 14.67 5.09 All 955 651 "a85 19 0.50 6.00 10.50 18.00 18.50 18.50 18.50 14.28 5.25 2Qb'3593352

C1 WD Childhood 0-18 yrs, Weighted duration (years) H1S70LOGICALLY CONFIRMED DIAGNOSIS 7otal Exposed Unexposed ExGUded Min P10 01 f Median ~ Q3 ( P90 Max Mean [ Std Men GSf3 152 74 77 1 0.50 1.90 7.50 11.00 18.50 21.00 36.75 12.70 7.88 Controls 680 335 236 ~ 9 0.15 1.90 8.50 15.50 19.00 30.00 65.50 15.32 10.11 All '32 409 313 10 0.15 1.90 8.50~ 14.50, 19.00 27.00 65.50 14.85 9.79 Wonlen es 531 333 190 8 0.10 1.75 8.00 14.25 19.00 26.00 68.00 14.45 9.95 ~ ContrOls 1076 716 344 16 0.10~ 2.25 9.50 16.20 19.00 25.80 57.50 ~ 15.22 9.19 All 1607 1049 534 24 0.10, 1.90 9.00, 14.50 19.00 26.00 68.00 !!f 14.98 9.441 All Cases 683 407 267 9 0.10 1.80 7.88 13.50 19.00 25.50 68.00 14.13 9.62 Controls 1656 1051 580 25 0.10 2.00 9.50 15.75 19.00, _ 26.50 65.50 15.25! 9.49 AlI 2338 1458 8471 34 0.10 °.90 9.00 74.50 19.00 26.00 68.00 74.94 9.54 ~~QUA1.FOt1S CELL CARCINOMA Men C8SC5 28 4 24 0 7.50f 7.50 9.25 11.00 15.00 19.00 19.00 1 12.13 4.87 Conttds 580 335 236 9 0.15~ 1.90 8.50 15.50 19.00 ~ 30.00 65.50 1 15.32 10.11~ AN 608 339 260 9 0.15 1.90 8.50 15.50 19.00 30.00 65.50 15.28 10.071 Woma1 C~SCt 97 59 37 1 0.65 1.90 11.00 16.50 20.25 28.50 68.00 17.33 12.72 ConlrOlS 1076 716 344 16 0.10 2.25 9.50 16.20 19.00 25.80 57.50 15.22 9.19 All 1173 ,'-75 381 17 0.10 2.25 9.50 16.25 19.00 26.00 68.00 15.38 9.51 A!! Cases 125 63 61 0.65 2.55 11.00 16.25 19.00 28.00 68.00 17.00 12.41 Controls 1656 1051 580 25 0.10 2.00 9.50 15.75 19.00 26.50 65.50 15.25 9.49 All 1781 11141 641 26 0.10 2.00 9.50 15.88 19.00 27.00 68.00 15.35 9.68 MMI C35M Controls All 14 500 594 335 342~ 236 243 0 9 9 3.00 0.15 0.15_ 3.00 1 10.50 1.90 8.50 1 90, 8.50 11.00 15.50 15.35 11.00 19.00 19.00 18.50 18.50 30.001 65.50 28.501 65.50 10.86 15.32 15.231 4<48 10.11 10.04 WOR1Qn C85es 67 4 24 t 0.75 1.10 5.50 12.88 19.00 27.00 38.00 73.10 9.21 Controls 1076 716 344 16 0.10f 2.25 9.50i 16.20 19.00 2s.80 57.50 15.22 9.191 All 1143 758~ 368 17 € 0.101 1.90 9.50 15.50 19.00 26.00 57.50 15.11~ 9.201 AI! C83QS 81 49 31 1 0.75 1.10 6.50 11.00 19.00 27.00 38.00 12.78 8.70 Contr0ls 1656 1051 Seo 25 0.10 2.001 9.50 15.75 19.00 26.50 65.50~ 15.25 9.49 A11 1737 '100 611 26 0.10 1.901 9.38 15.50 19.00 26.75 65.50 15.14 9.47 ADENOCARC I NO MA Men E Cases ontrols A}I 80 660 580 44 335 l 379 35 236 271 1 1 0.50 9! 0.15 101 0.15 1.75 1.90 1.90 6.00 8.50 8.50 11.00 15.50 14.50 18.75 21.00( 36.00 19.00 30.00 65.50 19.00 28.10 65.50 12.08 15.32 14.94 8.151 10.11 9.95 WOfrien C~SQS 281 76 1 101 4 0.25 1.70 7.50 13.05 19.00! 26.00 57.00 13.85 9.68 Conttols 1076 716 344 16 0.10 2.25 9.50 16.20 19.001 ^<5.80 57.50 15.22 9.191 All 1357 892 445 20 0.10 1.90 9.18 14.50 19.00i 25.80 57.50 14.95 9.301 AlI CroSQ3 361 220 136 5 0.25 1.73 6.50 11.96 19.00 25.25 57.00 13.50 9.40 Controls 16 5 6 1 1 05 580 25 0.10 ~ 2.00 9.50 15.75 19.00 26.50 65.501 15.25 9.49 At/ 201 7 1 i27 1 716 30 0.10 1.90 9.00 14.50 19.00~ 26.00 65.50 14.95 9.49 OTHER Men Cases 30 19 11 0 1.50 2.50 8.50 17.11 19.00 26.50 36.75 14.96 8.66 Controls 580! ~ 335 236111 9 1 0.151 1.90 8.50'E 15.50 19.00 30.001 65.50 15.32 10.11 All 810 354247 9 0.15 1.90 8.50/ 15.501 19.00 28.501 65.50 15.30~ 10.03 Women Cases e8 56 28 2 0.10 3.40 9.25 16.75 19.00 21.00 36.001 14.32 7.32 f Controls 1076 ' ' I ! All 1182 7721 372 8 0 .101 2.50 9.50 16.28 19.00 25.50 57.50 15.16 9.07 AIl C;73lS 116 75 39 2 0.10 3.40 9.00 17.00 19.00 21.00 36.75 14.48 7.63 Conlrols I 1656 1051 ~ 580 25 0.10 2.00 9.50~ 15.75I ts.oo 26.50 65.50 5.25 9.49 All 1772 1126 619 27 l 0.10 2.251 2.50 16.06 19.00 26.00 65.50 1 15.20 9.38 >75h: OF LIFESPAN IN RURAL AREA OR INTERMEDIATE CITIES MQt1 Cases 'a6 30 45 i 0.50 1.60 8.50 11.00 14.50 18.75 36.00 11.62 7.18 Controls 225 120 103~ 2!, 0.85 2.50 7.50 14.25 19.001 33.13 38.00 ~ 15.14 10.10 All 301 150 14 31 0.50 2.05 7.50 11.00 19.00 32 50 38.00~ 14.44 9.67 WottSQn CasQS 237 140 941 3 0.45 2.18 11.00 14.25 19.00 28.50 68.00 15.73 10.45 Controls ~ 462 290 169'E 3 0.101 2.25 10.00~ 16.38 19.00 25.88 43.50 15.14 9.02 All 699 430 263! 6 0.101 2.25 10.501 15.50 19.00 27.00 68.00 15.33 9.50 AIl CisQS Controls All 313 687 1000 170 410 580 139 41 0.45 272 S 0.10 411~ 91 0.10 1.75 2.50 2.10 9.501 13.88 9.50 15.50 9.50) 14.25 19.001 27.38 19.00 28.50 19.00 28.25 68.00 15.00 3.50 15.14 68.001 15.10 10.06 9.34 9.55 >75Y. OF LIFESPAN IN URBAN AREA Men Cases 48 Controls 257 AII 305~ 33 155I 188 15 0 96 6 111 6 1.05 0.15 0.15 2.50 6.50 1.901 E.50 90 8.13 15.50 19.00 ?7.50 19.00 16.98 19.00 26.501 36.75 14.32 25.001 65.501 t5.52 26.501 65.50( 15.31 8.57 10.53 10.21 Won Qn C35es 196 137 55 4 0.10 1.50 6.50 11.63 19.00 21.00 50.00 12.70 8.51 COn1ro,L 454 326 ° 8 9 0.10 2.95 10.50 77.50j 19.00 ) 26.501 5:.50 1 5.94 9.60 All ~ 650 463 174_ 13 0.10 1.90 9.00 14.501 19.00 25.631 57.501 14.98 9<40 AA Cases I 244 170 70 4 0.10 1.88, 6.50 ?2.44 19.00 21.50 50.00 13.01 8.52 Controls 711 481 215 15 0.10 2.25 9.50 ~ 17.50 19.00 26.00 65.50 15.80 9.90 All 955 651 285 19 0.10 1.90 9.00 15.50 19.00 25.63I 65.50 15.08 9.63 EryVO~.?~.J9JJ~~ Oescriptive statistics - Childhood 0-18_ years _

SIDH Spouse, Duration (hoursiday x years) ITALY 2 ~ Total Exposed Unexoased Exduded Min P10 I 01 I Median I 03 ~ P90 Max Mean ~ Std M~1 C95¢f 3 0 3 0 : ~ Controls 97 iS 82 0 10.00 10.86 16.00 36.40 145.71 202 50 230.57 79.871 1 79.44 All 100 16 85 0 10.00 10.86 ~ 16.00 36.40 145.71 202.50 230.57 79.44 79.871 WORktI C93C3 16 8 7 1 4.00 4.00 37.45 65.00 248.57 510.00 510.00 152.00 176.111 Controls 76 44 24 8 0.50 15.57 36.29I 74.07 150.57 240.00 285.43 102.28 84.53 All 92 52 31 9 0.50 15.57 36.29 68.00 166.07 248.57, 510.00 109.93 103.00 AA CUC3 19 8 10 1 4.00 4.00 37.45 65.00 248.57 510.00 510.00 152.00~ 176.11 Controls 173 59 106 8 0.50 14.00 28.00 59.14 150.57 237.71 285.43 96.47~ 83.29 All 192 67 116 9 0.50 14.00 28.00 60.00 150.57 240.00 510.00 103.10~ 98.57 ITALY 3 MCt1 CB:Cf ; 0 0 17.29 17.29 17.29 T7.29 17.29 17.29 17.291 17.29 0).00 COntr0lf /2 1 10 '< 1.30 1.30 1 1.30 1.30 1.30 1.30 1.301 1.30 0.001 All 13 2 10 1.30 1.30 1.30 9.29 17.29 17.29 17.291 9.29 ?1.30 WprtlCn CiSCf i5 8 4 3 82.14 82.14 143.36i 192.57 308.00 498.00! 498.001 233.50 133.67 COnlfOlf 38 11 13 14 1.50 96.00 105.75i E 175.00 207.14 220.00EEEi 267.431 155.63 73.081 All 53 19 17 17 1.50 82.14 I 117.00 180.00 220.00 308.001 498.00, 188.42f 107.13~ AA Ci38f 16 9 4 3 17.29 17.29 117.00 185.14 308.00/ 498.O0i 498.00 209.48 144.321 Controls 50 12 23 15 1.30 1.50 100.88 153.93 203.57 220.00' 267.43 142.77[ 82.711 AII 66 21 27 18 1.30 17.29 105.75 175.00 207.141 308.00 498.00 171.361 1.1.5.06, PORTUGALI MOn CafOf 16 3 13 0 1.60! 1.6D 1.60~ 90.00 140.86 140.86140.86 6 77.49 70.47 , Controlf a 0 a 0 I € ; I fAN 24 3 21 0 1.60 1.60I 1.6090.00 140.86 140.86 140.86 77.49 70.47 WoTtCn C9sef 33 17 16 D 9.43 14.29 114.29 232.57 306.43 444.00 475.71 225.51 144.15 COntr018 31 12 17 2 27.86 33.00 48.54 148.14 216.43 248.57 272.00 141.65~ 89.25 A11 64 29 33 2 9.43 27.86 95.001 197.14 262.29 406.71 475.71 190.81i 129.5C AU CeSCS 49 20 29 0 1.60 11.86 100.36 178.43 284.64 425.36 475.71 203.31I 744.76 ConUOlf 39 12 251 2 27.86 33.00 48.54 148.14 216.43 248.57 272.00 141.65! 89.25 AII 98 32 54~ 2 ':.60 27.86 79.29 150.43 259.71 377.14 475.71 180.19 128 82 PORTUGAL2 Mon Clasef 10 0 10 0 l Controls I 17 0[ 17 0 Af1 27 0 27 0 WOf11Cn C9s0f 23 14 6 3 6.86 12.86 29.71 108.00 211.711 292.29 378.86 136.03 117.92 Controls 36 12 21 3 3.14 6.00 12.36 53.16 99.57 128.00 150.00 58.98 ?t All 59 26 27 6 3.14 6.86 19.00 77.50 150.00 276.43 378.86 100.47 ^ L94 Ap CCases 33 14 16 3 6.86 12.86 29.71 108.00 211.71 292.29 378.86 136.03 117 9. COnlrolf 53 12 38 3 3.14 6.00 12.36 53.16 99.57 128.00 150.00 58.98 5C 3 Alt 86 26 54 ' 3.14 6.86 19.00 7.50 150.00 276.43 378.86 100.47 99 4[ MCn CiSCf 6 5 ~ 0 52.00 62.00 62.001 62.00 62.00 62.00 62.00 62.00 0 Oe Controls AIl 13~ 19 1 13 18 01 062.00 62.00 62.001 62.00~ 62.00 62.00 62.00I "2.001 0 00 WOmcn Cas05 ti5 28 '8 19 8.29I 21.00 61.93 167.51 233.36 333.20 525.43 163.21 12: 4e € Controls 146 ~ 78 37 31 2.571 15.00 54.00 145.00 I 230.00~ 373.32 630.00 165.93 147 2Ej i G? 1 8 B6 ' 230 OOf 630 00 C c All CiSCf Controls All 1 152 230 29 78 107~ r®^3 50 73 19 8.29 31 2.57 50 2.57 21 .00 15.00 18.86 62.00 54.00 54.00 1fi0_ 145.00 150.00 . 230.00 230.00 333.20 373.32 337.00 525.43 159.721 630.00 165.93~ 630.00 164.25 12 . _ 147 2E 140 2E SWEDEN Men Cases 23 15 3.43 3.43 4.00 38.50 78.46 190.57 190.57 54.71 66.22 ConltWf 36 9 27 0 3.00 3.00 5.00J 18.29 32.00 133.00 133.00 29.83 40.6C All 59 16 42 ' 3.00 3.43 4.50I 19.14 47.43 133.00 190.57 40.71 52.89 WOrt1Cn Cases 47 20 3I ti 0.10 7.48 17.63 54.57 127.79 201.07 330.55 83.57 85.43 Contlolf 76 41 35! 0.15 1.45 9.00 50.29 88.71 119.71 225.141 57.17 51.14 AH 123 61 58I 4 0.10 2.30 15.75 50.29 96.00 136.00 330.55 65.82 64.89 AX C9sCf 70 27 38 5 0.10 3.43 14.69~ 50.00 119.57 190.57 330.55 76.09 80.70 Controls 1121 50 62 0 0.15 i.88 8.93 36.14 86.86 122.51 225.14 52.25 50.17 AI) 182 °7 100 5 0.10 3.00 12.00 44.57 88.71 136.00 330.55 60.61 63.10 MCn t C35Qf 3 0 0 31 Contro4 14 0 0 14 ~ Aa 171 0 ® 0 17 WOtM:n G83CY ~ ^e31 1 ~0 0 23! ! ContrUf 126 0 0~ 126 ~ E ; AI/ 149 0 0 149 All Ci6Cf 26 0 0 26 s € Controls I 140 0 0~ 140I AfI [ 166 0 0 166 ~

S1UD Spouse, Duration (years) (non overlapping) ALL CENTERS 21 0 635 9338 ~ Total Exoosed Una sed Excluded ~ Min ~ P10 ~ 01 1 Median 1 03 ; P90 ~ Max ~ Mean Std I MU1 CSRS 14,1 23 118 0 1.00 2.00 10.00IE 16.00 30.00 32.00 44.00 17.67 12.161 ConUolf 1 531 68 462 1 2.00 5.00E 8.00! 16.00 26.50 40.00 44.00 18.31 11.98, All 6721 91 580 1 1.00 4.00 8.00f 16.00 28.00 35.00 44.00 18.15 71.961 Womon CaSes 509 393 187 19 1.00 4.00 14.00 27.00 36.00 43.00 54.00 25.18 13.731 Controlf 1011 613 376 22 0.50 7.00 17.00 27.00 35.00 ~ 42.00, 53.00 25.64 12.611 AN 1520 916 563 41 0.50 6.00 15.00 27.00 35.50 42.00~ 54.00 25.49 12.991 Af! Cases 650 326 305 19 1.00 4.00 13.00 26.001 36.00 43.00 54.00 24.65 13.741 Controls 1542 681 838 23 0.50 7.00 15.00 25.00 34.00 42.00 53.00 24.91 1.2.731 AJl 2192 1007 1143 42 0.50 6.00 14.00 26.00 35.00 42.00 54.00 24.82 13.061 ALL CENTERS WITH EDUCATIONAL LEVEL AND TYPE OF RESIDENCE Men Cases 92 12 80 0 2.00 4.00 10.00 11.25/ 26.00 31.00 32.00 16.46 10.52 Controls 470 59 410 2.00 6.00 10.00 18.00~ 29.00 40.00 44.00 19.78 12.04 AH 562 71 490 1 2.00 6.00 10.00 17.00~ 28.00 39.0044.00 19.22 11.79 WOf11Cn CaSCt 406 246 142 18 1.00 4.00 14.00 27.00 36.00 43.00 54.00 25.38 13.761 Controlf 868 643 303 22 0.50 8.00 18.00 28.00 36.00 43.00 53.00 26.24 12.531 All 1274 789 445 40 0.50 7.00 17.00 27.00 36.00 43.00 54.00 25.97 12.93 A>l CtSCS 498 258 222 is 1.00 4.00 12.00 26.50 36.00 43.00/ 54.00 24.96 13.741 Controls 1338 602 713 23 0.50 6.00 16.00 26.00 35.00 43.001 53.00 25.61 12.621 All 1836 860 935 41 0.50 7.00 15.00 26.00 35.00 43.001 '4.00 25.41 12.961 MGn Cases 104 19 85 0 1.00 2.00 4.00 14.00 31.00 34.00 44.00 17.55 13.001 ConUGf 306 39 267 0 2.00 5.00 8.00 15.00 27.00 40.00 44.00 17.67 12.291 All 410 58 352 0 1.00 4.001 8.00 15.00 28.00 ~ 35.00 44.00 17.63 12.41 WOn1Gn Cis@f 405 240 i49 16 1.00 3.00 12.00 25.50 36.00 43.00 54.00 24.68 14.051 Controls 750 452! 279 19 0.50 7.00 47.00 ~ 26.00 35.00 43.001 53.00~ 25.66 12.791, All 1185 692i 428 35 0.50 6.00 15.00 26.001 36.00 43.00 54.00 25.32 13.24~ Atl CiSCf 509 259 234 16 1.00 3.00` 11.00 25.00 36.00` 43.00 54.00 24.16 14.071 Controls 1056 491 546 19 0.50 7.00I 15.00 25.00~ 35.00! 43.00 53.00I 25.03 12.921 All 1585 750 780 35 0.50 6.00f 14.00 25.00 35.00f 43.00 54.00 24.73 13.331 FRANCE Men CaSCS 14 1 13 0 32.00! 32.00 32.00 32.00 32.00 32.00 32.00 32.00 1 0.001 Controls 23 3 20 0 6.00 6.00 6.00 10.00 18.00 18.00 78.00 11.33 ! ( 6.11i , Ali 37 4 33 0~ 6.00~ 6.00 8.00 14.00 25.00 "-2.00 32.00 ' 16.50 11.47'. WOmCn Cases 63 37 26 0 i.00I 2.00 9.00 17.00 28.00 43.00 52.00 20.51 15.25I Controls 128 83 45 0 0.50f 7.00 ~ 12.00 24.00 34.00 42.00 53.00 23.80 13.161 AJl 191 120 71 0 0.50 3.00 11.00 E111 22.50 33.50~ 42.00 53.00 22.79 13.851 All Cases 77 38 39 0 1.00 2.00 9.00 18.50 32.00 43.00 52.00 20.821 15.161 Controlf ~ 151 86! 65 0 0.50 6.00 ~ 12.00 24.00 33.00 42.00 53.00 23.37 13.16, AII 228 1241 104 0 0.501 3.00 11.00 22.00 33.00 42.00 53.00 22.58 13.79 GERMANY 1 Men CAsBs 18 3 15 0 4.00 4.00 4.00 11.00 23.00 23.00 23.00 12.67 9.611 ~ ContrNf 129 16 113 0 5.00 6.00 8.50 18.00 29.00 33.00 1 35.00 18.75 10.581 All 147 19 128 0 4.00 5.00 8.00 17.00 27.001 33.00 1 35.00 17.79 . 10.43' Wt%nCn CsSCf 58 37 19 2 1.00 6.00 11.00 25.00 35.00 41.00 51.00 24.22 13.46: Controls 100 60 40 0 1.00 9.50 17.00 22.00 31.00% 42.50 51.00 24.40 11.73' All 158 97 59 2 1.00 7.00 17.00 24.00 33.00` 41.00 51.00 24.33 12.35, AN CisQf 76 40 34 2 1.00J 5.00 10.00 24.50 35.00 40.50 51.00 23.35 13.47; Controlf 229 76~ 153 0 1.00' 7.00 16.001 21.50 3100 39.00 . 51.00, 23.21 11.66 All 305 116 187 2 1.00 7.00 15.00 22.50 32 .00 40.00 51.00 23.26 12.261 GERMANY2 Men CeSCf 29 4 25 0 2.00 2.00 6.75 17.75 26.00 28.00 I 28.00 16.38 11.88~ COntrolf 65 5 60 0 5.00 5.00 8.00 15.00 18.00 44.00J 44.00 18.00 15.441 All 94 9 85 0 2.00 2.00 8.00 15:00 24.00 44.00I 44.00 17.28 13.151 WOn1Cn Cases 113 72 41I 0 1.00 4.00 14.50 29.00 39.00 44.00 54.00 26.24 14.33. Controlf 98 60 38II 0I 2.00 5.50 14.00 20.50 30.00 42.00 45.00 22.93 12.41' All 211 132 791 0 1.00 5.00 14.001 23.00 36.50 43.00 54.00 24.73 13.54 Aq CaSCf 142 76 66 0 1.00 4.00 14.00 28.00 38.50 44.00 54.00 25.72 14.31 Controls 163 65 98 0 2.00 5.00 14.00 20.00 30.00 42.00 45.00 22.55 12.60 AII 305 141 164 0 1.00 5.00 14.00 23.00 36.00 43.00 54.00 24.26 13.59 G17tMANY 3 MMt C9sOf 10 0 10 0 Controls 14 13 0 20.00 20.00 20.0020.00! 20.00 20.00 20.00 20.00 0.00 All 24 1 23 0 20.00 20.00 20.00 20.0020.00 20.00 20.00 20.00 0.00 WanCn Cases 21 9 12 0 8.00 8.00 23.001 28.00 38.00 45.00 45.00 28.00 12.96 Controif 38 16 22( 0 6.00 10.00 20.50 30.00 33.50 42.00 51.00 27.75 11.54 All 59 25 34 0 6.00 10.00 21.00 30.00 34.00 42.00 51.00 27.841 11.80 All Cases 31 9 22 0 8.00 8.00 23.00 28.00 38.00 45.00 45.00 28.00 12.96 Controlf 52 17 35 0 6.00 `:0.00 20.00 30.00 33.00 42.00 51.00 27.29 11.33 AIl 83 26 57 0 6.00 10.00 20.00 29.00 34.00 42.001 51.00 7.54 i1.6' ITALY 1 Men CasCS 8 0 10.00 10.00 10.00 o 10.00 ':0.00 10.00 10.00 0.0C Controlf ! 103 14 88 1~ 2.00 3.00 10.00 16.50 25.00 30.00 39.00 17.64 10.55 All 171 15 95 1i 2.00 3.00 10.00 15.00 25.00 30.00 39.00 17.13 10.36 WorMn CsfCf 32 22 9 1 1.00 10.00 16.00 27.50 33.00 40.00 45.00 25.32 11.74 Controls 118 83 35 01 2.00 7.00 17.00 28.00 36.00 42.00 48.00~ 26.00 12.62 All I 150 105 44 11 1.00 7.00 17.00 28.00 36.00 42.00 p 48.00t 25.86 12.39 All Cases 1 40 23 16 1..00 10.00 15.00 25.00 33.00 40.00~ 45.00 24.65 11.91 Controls I 221 97 123 ii 1~ 2.00 6.00 15.00 26.00 34.00 41.00 48.00 24.79 12.64 All ! 281 120 139 2 1.00 7.00 15.00 26.00 34.00 41.00 48.00 24.77 12.46

SIUD Spouse, Duration (years) (non overlapping) HISTOLOGICALLY CONFIRMED DIAGNOSIS Total i EXpOSed Unexposed Excluded Min P10 01 ; Median 03 P90 Max Mean Std ~ MU1 CeSCf 152 23 129 0 1.00 2.00 10.00 16.00 30.00 32.00 44.00 17.67 12.16 Controls 580 68 510 2~ 2.00 5.00 8.00 16.00 26.50 40.00 44.00 18.31 1.1.98 All 732 91 639 2~ 1.00 4.00 8.00 16.00 28.00 35.00 44.001 18.15 11.96 WOfikxt Cases 531 302 210 19 1.00 4.00 14.00 26.00 36.00 43.00 54.00 25.14 13.60 Controls 1078 632 420 24 0.50 7.00 t7.00 27.00 35.00 42.00 ~ 1 53.00 25.73 12.65 AN 1807 934 630 43 0.50 6.00 15.00 27.00 35.00 43.00 54.00i 25.541 12.96 AlI C65M 603 325 339 19 1.001 4.00 14.00 25.00 35.00 42.00 54.001 24.61 13.62 Conttots 700 930 26 0.50 I 7.00 15.OOf 26.00 35.00 42.00 53.00 25.01 12.77 A!1 10251 t269 45 O.SO 6.00 15.00 25.00 35.00 42.00 54.00 24.881 13.04 SQUAMOUS CELL CARCINOMA Men Cases 28 27 0 30.00 30.00 30.00 30.00 30.00 30.00 30.00 30.00 0.00 Controls 580 68 510 2 2.00 5.00 8.00 16.00 26.50 40.00 44.00 18.31 11.98 AJI 608 69 537 2 2.00 5.00 8.00 16.00 27.001 40.00 44.00 18.48 11.98 Wort1Cn CBSCf 97 58 36 3 1.00 2.00 i1.00 ' 27.50 38.00 43.00 54.00 24.26 14.85 Controls 1076 632 420 24 0.50 7.001 17.00EEE1 27.00 35.00 42.00i 53.00 25.73 12.65~ AII 1173 690~ 456 27 0.50 7.00 16.00! 27.00 35.00 42.50i 54.00 25.61 12.85 AII CEscS 125 59 63 3 1.00 2.00 11.00 28.00 38.00 43.00 54.00 24.36 14.74 Conlrolf 1656 700 930 26 0.50 7.00 15.00 26.00 35.00 42.00~ 53.00 25.01 12.77 AlI 1781 759 993 29 0.50 6.00 15.00 26.00 35.00 42.00~ 54.00 ~ 24.96 72.93 SMALL CELL CARCINOMA Mcn Cases 14 2 12 Controls S80 68 510 All 594 70 522 0 2 2 23.00 2.00 2.00 23.00 5.00 5.00 23.00 27.00 8.00 16.00 8.00 16.00 31.00 3t.00 26.50 40.00 27.00 _ 39.50 31.00 44.00 44.00 27.00 18.31 18.56 5.66 ?t.98 11.92 Women CiSCf 67 38 27 2 2.00 5.00 15.00 28.00 39.00 43.00 51.00 26.18 13.97 Controls 1076 632 420 24 0.50 7.00 17.00 27.00 35.00I 42.00 ~ 53.00 ~ 25.73 12.65 AIl 1143 670 447 26 0.50 7.00 17.00 27.00 35.001 43.00 53.00 25.75 12.72 AIt CiSCS 81 40 39 2 2.00 5.50 15.50 28.00 38.00 43.00 51.00 26.23 ?3.64 Controls 1656 700~ 930 26 0.50 7.00 15.00~ 26.00 35.00 42.00 53.00 25.01 12.77 All 1737 7401 969 28 0.50 6.50 15.00 26.00 35.00 42.00 53.00 25.07 12.81 ADENOCARCINOMA MCn CilfCf 80 15 65 0 1.00 2.00 4.00 11.50 24.00 34.00 44.00 15.50 12.721 Controls 560 68 510 2 2.00 5.00 8.00 16.00 26.50 40.00 44.00 18.31 11.981 All 660 331 575 2 1.00 4.00 8.00 15.00 26.00 39.00 44.00 17.80 2.09 Women °C93cs 281 156 115 10 1.00 7.00 15.00 26.50 36.00 44.00 52.00 25.57 t3.23 Controls ' 1076 6321 420 241 0.50 7.00 17.00 27.00 35.00 42.00 53.00 25.73 12.65 AN 1357 768_ 535 34 0.50 7.00 16.00 27.00 35.00 43.00 53.00 25.70 12.76 All CiSCb 351 °71 180 10 1.00 4.00 14.00 25.00 35.00 43.00 52.00 4.69 2 13.46 Controls 1656 ~ 700 930 26 0.50 7.00 15.00 26.00 35.00 42 00 53.00 25.01 12.77 iAlt 2017 871 1110 36 0.50 6.00/ 15.00 25.00 35.00 42.00 53.00 24.94 12.90~ OTHER Men Cases Controls ~ All ~WOmOn a SOb 80 5 25 0 4.00 4.00 10.00 16.00 28.00 32.00 32.00 i8.00 11.83 5601 68 510 2 2.00 5.00 8.00 16.00 26.50 40.00 44.00 18.31 11.98 6101 73 535 2 1 2.00 5.00 8.00 16.00 27.00 39.00 44.00 18.29 11 .89 85 50 32 4 ?.00 3.50 12.00 '24.50' 35.00 40.00 48.00 24.04 1 3.24 Controls 1076 632 420 24 0.50 7.00 17.00 27.00' 35.00 42.00 53.00 25.73 ~ 12.65 I 1162 Aq 682 452 28 0.50 7.00 17.00 26.00' 35.00 42.00 53.00 25.60 ?2.70 All 1 Cases ! 116 Controls I 1656 All 1772 55 700 755 57 930 987 4 25 30 i.00 0.50 0.50 4.00 7.00 6.00 12.00 15.00 15.00 24.00 26.00i 25.00 35.00 35.00 ` 35.00 40.00 48.00 42.00~ 53.00 42_001 53.00) 23.49 25.01 24.90 13.14 12.77 12.80 ~75y, OF LIFESPAN IN RURAL AREA OR INTERMEDIATE CITIES - M11Cn CBSCf ~ 76 69~ 01 1.00 1.00 ~ 4.00 16.00 32.00 34.00 34.00 18.29 13.981 Controls ~ 225 141 2101 11 2.00 5.00 8.00 18.50~ 40.00 43.00 43.00 22.57 15.07 I ~ All 901 e 21 2791 1 1.00 4.00 8.00 18.00 32.00 41.00 43.00 14.51 21.14 Wort1Cn 237 C9S0f '37 97 3 1.00IE 5.00 14.00 27.00 37.00 43.00 52.00 25.41 13.59 ContfOls 462~ 255 201 6 0.501 6.00 15.00 25.00 33.00 42.00 51.00 24.42 12.53 AN 699 392~ 298 91 0.50 6.00 14.00 25.00~ 35.00 42.00 52.00 24.77 12.90 All CIDSCS 313 144 166- 3 00 5.00 t3.00 26.50 36.00 43.00 52.00 25.06 73.65 Controls 687 269 411 7 0.50 6.00 15.00 25.00 33.00 42.00~ 51.00 24.33 12.64 All 1000 4131 577~ 10, 0.50 6.00 14.00 25.00 34.00 42.001 $2.00i 24.58 12.99 MCn Cases 48 12 36 0 2.00 12.75 2.00 10.50 26.00 31.00 44.00 17.63 12.561 Controls 257 40 216 2.00 I 14.00 5.00 8.00 24.50~ 36.00 44.00 16.851 11.63f A11 305 52 252 2.00 E 4.00 8.001 14.00 24.50 33.00 44.0017.03 11.73 Womcn Cases 196 118 67 11 1.00 4.00 14.00 29.00 36.00! 43.00 54.00 25.53 13.53 CONr01s 454 301 140fI 13~ 1.00 8.00 19.00! 29.00 37.00 43.00 I 53.001 27.24 12.74 A!1 650 419 2071 24~ 1.00 7.00 18.00 29.00 36.00 43.00 54.0026.76 12.97 AIl CaSCS 244 130 103~11 1.00 3.501 13.00 27.00 35.00 42.50 54.00~ 24.80 13.59 CCiftr015 s'11 341 3561 1:4 1.00 7.00 16.00, 28.00 36.00 43.00 53.00' 26.02~ 13.03 All 9551 471 4591 25 1.00 7.00 15.00 28.00 36.00 43.00 54.00 25.68 13.19 ~063593388

D_S1 UD Spouse, Durafion (years) (non ovedapping) AS•1. cF.IYSER8 Lavel of.xqosura ~ Casns Controls OR 1 95% CI OR 2 95'/. CI ~ OR(3 95% CI € OR(4 95% Cl ( OR(S) 95% Ct ( Non 6XpOSOd 305 838 1.00 1.00 1.00 t.oo 1.00 _ 0<81UD<3A 223 498 1.05 0.83- ( 1.33) 1.06 ( 0-82- 1.36) 1.02 ( 0-76• 1•36)1 1.05 ( 0•83- 1.33) 1.05 ( 0.81- 1.37) 34<S1UD<.42 65 03 9 ( 1.63 1.12- .37) 1.58 ( 1.06- 2.35) 1.56 ( 1.00- 2.44)! 1.69 ( 1.15- 2.46) 1.66 ( 1.07- 2.58) 42<SiUD 38 80 1.07 0.66- ( 1.68) 1.04 ( 0.65- 1.68) 0.92 ( 0.54- 1.56)/ 1.17 (, 0.74- 1.85) 0.91 ( 0.54- 1.52) Excluded/Trend 19 23 o.fo 0.10 0.15 1€ 0.10 0.11 ALL CENTERS WITH EDUCATIONAL LEVEL AND TYPE OF RESIDENCE Nan •xposao 87 1 620 t.0o 1.00 1•00 ) 1.00 1. 00 0<S1UD< 34  153 371 1.05 ( 0.79- 1.40) 1.05 ( 0.79- 1.40) 1.02 ( 0.76- 1.36) 1.04 ( 0.77- 1.39) 1.09 f , 0.80- 1.49) 34<S1UD< 42 47 a1 1.sa ( 1.02- 2.46) 1.59 ( 1.02- 2.48) 1.56 ( 1.00- 2.44) 1.62 ( 1.04- 2.53) 1.79 { 1.09- 2.92) 42< sluo 7 67 0.96 ( 0.57- 1.64) 0.96 ( 0.57• 1.64) 0.92 ( 0.54- 1.56) 1.03 ( 0.60- 1.76) 0.95 ( 0.54- 1.68) Ercludodlrrend 84 199 0.48 0.46 0.62 0.48 0.52 ALL CENTERS WITH DIETARY DATA Non .xposad ( 231 534 1.00 1.00 1.00 1.00 1 1.00 0<S1U0<3A 178 352 1.05 ( 0.81• 1.37) 1.07 ( 0.81- 1.40) 1.04 ( 0.76- 1.43) 1.05 ( 0.80- 1.37) 1.05 { 0.81- 1.37) 34<S1UD<42 49 69 1.67 ( 1•08- 2.59) 1.74 ( 1.11• 2.73) 1.77 ( 1.08- 2.91) 1.71 ( ~ 1.10- 2.66) 1.66 ( 1.07- 2.58) 42<S1UD 29 62 0.93 ( 0.55- 1•55) 0.95 ( 0.57- 1.61) 0.90 ( 0.51- 1.60) 1.00 ( 0•58- 1.68) 0.91 ( 0.54- 1.52) Excluded/Trand 22 39 0.27 E 0.28 ) 0.40 0.26 I 0.29 FRANCE Non •xposetl 0<S1UD<34 34<S1UD<42 42<S1UD Excludod/Trend GflRMANYi Non .xposd D<S1U0<34 34<S1U0<42 q2<S1U0 €xcludad/Trond 39 65 1.00 1-00 1.00 1.00 i 1.00 ~ ^c9 ! 65 0.78 ( 0.41- 1.50) 0.65 ( 0.31- 1.3fi) 0.65 ( 0.25- 1.66) 0.75 ( 0.39- 1.44) 0.77 ( 0.40- 1.47)~ 4i 11 0.67 ( 0.19- 2.36) 0.44 ( ~ 0.11- 1.86) 0.48 ( 0.08- 2.99) 0.67 ( 0.19- 2.38) 0.66 ( 0.19• 2.36) ~ f 5 10 0.91 ( 0.27- 3.05) 0.63 ( 0.16- 2.53) 0.63 ( 0.09- 4.42) 1.01 ( 0.29- ~ 3.53) 0.86 ( 0.25- 2.93)1 !! 0 't 0 0.51 0.28 ~ 0.25 0.46 11 0.47 t 34 153 1.00 1.00 1.00 1.00 7.00 29 64 1.25 ( 0.64- 2.43) 1.41 ( 0.68- 2.94) 1.39 ( 0.67- 2,90; 1.24 ( 0.63- 2.47) t.42 ( 0.71- 2.82) 9 5 5•it ( 1.48-17.64) 7.38 ( 1.65-32.97) 6.87 ( 1.51-31.17) 5.49 ( 1.57-19.11) 5.61 ( 1.56-19.85) 2 7 0.47 (, 0.09- 2.49) 0.47 ( 0.08- 2.58) 0.45 ( 0.08- 2.50) 0.48 ( 0.09- 2.54) 0.40 ( 0.07- 2.18) 21 OI 0.23 0.31 t 0.37 0.26 ( 0.26 GERMANY2 Non @xpoi0tl D<S1UD<34 34<S1U0<43 42<S1UD , ss 9s 1.00 1.00 1.00 1.0o i.oo ` 49 51 0,97 ( 0.55- 1.71) 0.91 ( 0.51- 1.62) 0.85 ( 0.48• t.53) 0.96 ( 0.54- 1.70) 0.95 { 0.53• 1.68) 16 6 2.63 ( 0.93- 7.41) 2.48 ( 0.88- 7.03) 2.27 ( 0.79- 6.51) 2.63 ( 1 0.93- 7.41) 2.48 ( 0.87- 7.04) ~ 11 8 1.44 ( 0.50- 4.14) 1.37 ( 0.47- 3.97) 1.34 ( 0.45- 3.96) 1.42 ( 0.49- 4.11) 1.45 ( 0.50- 4.17) 6xcludad/Trond 0 0 0.19 0.25 0 0.34 0.19 1 0.19 j GERMANY3 Non expo s.d 3-5 t.00 1.00 ) 1.00 1.00 1.00 ~ I 0<S1UD 13 0.76 ( 0.22- 2.59) 0.73 ( 0.21- 2.59) 0.43 ( 0.11- 1.67) 0.79 ( 0.21- 2.91) 0.67 ( 0.19• 2.39) 34<S1UDe42 2 0.71 ( 0.05- 9.20) 0.68 ( 0.05- 9.62) 1.11 ( 0.06-20.63)f 0.75 ( 0.06- 9.78) 0.80 ( 0.06-11.04) ~ 42<S1U0 2 2.06 ( 0.24-17.87) 1.99 ( 0.22-18.36) 1.08 ( 0.11-10.79) Ei 2.95 ( 0.31-27.71) 1.45 ( 0.16-12.98) !! c'.rcluded/Trend 0 0.92 0.95 0.70 0.88 EEE ; o.s1 Non 0%pOSCtl 123 1.00 1.00 1.00 1.00 ~ 0<S1UD<34 18~ 71 1.03 ( 0.44- 2.40) 1.32 ( 0.54• 3.2i)1 1.16 ( 0.47- 2.87) 1.34 ( 0.55- 3.30) ( 34<S1U0<42 3~ 17 0.71 ( 0.17- 2.95) 0.96 ( 0.22- 4.14) 0.84 ( 0.19- 3.64) 63) 0.84 ( 0.20- 3. { 42<S1U0 2~ 9 0.95 ( 0.17- 5.35) 1.19 ( 0.20- ".92) 1.04 ( 0.18- 6.09) 1.34 ( 0.23- 7. 98 ) 1 Fxcluded/Trand 1 0.78 0.90 ~ 0.89 0.82 , ~ ITALY 2 Non ox(ossd 10 106 1.00 1.00 1.00 ( 1.00 0<S1UD<.34 5 45 0.45 ( 0•13- 1.61) 0.37 ( 0.09- 1.54) 0.43 ( 0.07- 2.57) 0.42 ( 0.12- 1.49). 34<S1UD<42 2 14 0.52 ( 0•09- 2.99) 0.56 ( 0.09- 3.47) 1.02 ( 0.13- 7.95) 0.54 ( 0.09- 3.06) 1 42<StuD 5 0.76 ( 0.07- 8.15) 0.68 t. 0.06- 7.80) 0.00 ( o.oo•ss.ss) 0.81 ( ~ 0.07- 8.71) F,rcluded/Trend 1, 3 0.37 0.42 € 0.31 0.36 II 1 Non oxpos.d 4 23 1100 t.oo 1.00 1.00 1.00 ' 0<S1UD<34 6 17 1.79 ( 0.37- 8.69) 1.54 ( 0.29- 8.19) 0.55 ( 0•09- 3.48) 1.66 ( 0.32- 8.50) 2.98 ( 0.52-17.15) ~ 34<S1UD<42 1 5 0.78 ( 0.06• 9.71) 0.70 ( 0.06- 8.99) 0.93 ( 0.05-18.37) 0.92 ( 0.06•13.86) 0.81 ( 0.06-10.16) 4 3.52 ( 0.48•25.94) 4.20 ( 0.50-35.49) 1.95 ( 0.18-21.07) 3.83 { 0.49•29.67) 4.76 ( 0.44•52.00) 1 1 0.38 0.37 0.38 0.35 , 0.40 Non •xposaa ! 29 25 1.00 i.oo O<S1UD<34 11 12 1.00 ( 0.35- 2,87) ~ 0.95 ( 0.33- 2.72) 34<S1U0<42 6 1 7.27 ( 0.75•70.68) ~ 7.ao ( 0.76•72.01) ~ 42<§tU0 3 1 4.51 ( 0.33-81.13) i 4.67 ( 0.35-62.86) Excluded/Trend o 0 0.09 j o.09 PORTUGAL2 Non ixpoSOd OegtUD<.34 34<S1UD <42 ~ 42<S1UD j e~rcludod/Trandl 16 38 1.00 1.00 ~ 1.00 10 12 4.78 ( 1.20-19.02) 3.06 ( 0.67-13.98) € 4.26 ( 1.05-17.38) 4 2 8.55 ( 1.11-65.99) 4.73 ( 0.51•44.26) ~ 8.28 ( 1.09-62.72) 2 1 16.45 ( 0•83•99.99) 15.89 ( 0.56•99.99) 15.53 ( 0.81-99.99) 0 0.01 o.or ~ 0.01 ) SPA1N Non expos9d 23 50 1.00 1.00 1.00 1.00 1.00 0<S1U0<34 24 50 1.03 ( 0.49- 2,19) 1.06 ( 0.48- 2.34) 1.09 ( 0.49- 2.46) 1•07 ( 0.49- 2.30) 1.01 ( 0.47- 2•17) 34<S1U0<42 9 25 0.82 t 0.31- 2.21) 0.94 ( 0.33- 2.65) 0,84 ( 0.28- 2.47)1 0.83 ( 0.31- 2.22) 0.81 ( 0.30- 2.79) 42<S1U0 2 16 0.21 ( 0.04- 1.07) 0.20 ( 0.04- 1.08) 0.17 ( 0.03- 0.95) 0.24 ( 0.05- 1.26) 0.23 ( 0.04- 1.18) Excluded/Trend T3 18! 0.19 0.16 0.18 0.19 0.21 ) NNOn •xposatl 38 62 1.00 1.00 1.00 1.00 o<Stuo<3a J 2s 44 1 .08 ( o.5s• 2.11) 1.08 ( 0,55- 2.11) ~ 1.10 ( o.ss• 2.1s) 1.to ( 0.56- 2.16)1 34<S1U0<42 ! 4 4 1.81 ( 0.41- 8.01) 1.94 { 0.42- 8.90) 1 1.87 ( 0.42- 8.27) 1.75 ( 0.39- 7.91)1 42<S1UD I 2 2 1.55 f 0.20-12.15) 1.38 l, 0•17-10.99)I 1.65 ( 0.21-12.85) 1.89 ( 0.24-15.09)1 Sxcluded/Trendl 0 0 0.49 ) 0.51 I i 0.44 0.44 E UNITED KINGDOM Non •xposetl 0<S1U0<34 34<S1UD<r42 42<S1U0 Excludod/Trandl a 60 1.00 1.00 1.00 1.00 1.00 10 54 1.49 ( 0.52• 4.26) 1.49 { 0.51- 4.35) 1.37 ( 0.46- 4.08) 1.31 ( 0.43• 3.96) 1.58 ( 0.54- 4.59) 6 11 4.39 ( 1.24•15.60) 3.92 ( 1.07-14.30) 3.71 ( 1.01-13.65)~ 4.50 ( 1.25-16.14) 4.52 ( 1.25-16.26) 2 15 1.06 ( 0.20- 5.66) 1.06 ( 0.19- 6.00) 0.95 ( 0.17- 5.51) 1.18 ( 0.22- 6.50) ( 0.20- 5.84) 1.08 0 0 0.16 0.16 0.22 0.14 1 0.14 (1) Model /ncfude sex, center, sex center and age (2) Model inGude sex, center, sex'cEnter, age and proportion of residential type in the last 35 yrs (REUP) 13) Mode) lndude sex, center, sex•rrn/er, age, proportion of residential type in the last 35 yrs (REUP) and educational level (EDUC) (4) Model include sex, center, sex'center, age and duration of exposure to list A agents (CCLAY) • (5) Model Include sex, center, sex'center, age and frequency consumption of vegetables (VEGE) ~=©63593362 a:~

c'tdND Chi7dhood 0-18 yrs, Weighted duration (years) MEN ONLY Total Exoosed Unexposed ExGuded ".lin ° P10 1 01 Median Q3 R90 ~ Max ~ Mean I Std Men O;aLCf 157 76 80 1 0.50 1.90 ts.00 11.00 18.50 21.00 36.75 12.84 7.821 COnIrolII 580 335 236 9 0.15 1.90 8.50 15.50 19.00 30.00 ~ 65.50 15.32 10.11! All 737 411 316 10 0,15 1,90 8.50f 14.50~ 19.001 26.50~ 65.50~ 14.86 9.771 Wornen C~SC3 0 9 0 0 € '- I Controls 0 0 0 0 All 0 0 0 0 ~ ~ ~ € t ! AJ) C9;C; 157 76 60 1 0.50 1.90 8.0011.00 18.50 21 .00 36.75 12.84 7.82: Controls 580 335 236 9 0.15 1.90 8.50 15.50 99.00 30.00 65.50 15.32 10.111 All 737 411 316 10 0.15 1.90 8.50 14.50 19.00 26.50 65.50 14.86 9.771 Mw Casts a o 0 s7 Controlf 0 0 0 0 I ~ ---- --- An 0 0 0 0 E E ~ I WtXnCn C35CS 550 344 198 8 0,10 1.85 8.50 14.25 19.00 26.00 68.00 14.58 9.961 Conttolt 1076 716 344 16 0.10 2.25 9.50 16.20 19.00 25.80 57.50~ 15.22 9.191 AN 1628 1060 642 24 0.10 1.90 9.44 14.50 19.00 25.90 68.00 15.01 9.451 AA CaSC3 550 344 198 9 9.101 1.85 9.50 14.25 19.00 26.00 68.00 i4.58 9,86 Control; 1076 716 344 16 0.10 2.25 9.50 16,20 19.00 25.80 57.50 15.22 9.191 All 1826 1060 542 24 0.10~ 1.90 9.44 14.50 19.00 25.90 68.00 15.01 9.45j POPUt.ATION BASED STUDIES MCY1 Ci3C1 91 ~ 55 35 1 0.50 1.80 5.50~ 11.00 15.50 22.00 36.00! 11.46 7.791 Controls 444 268 169 9 0.15 1.90 7.15 13.00 19.00 24.00 ~ 65.SOEEi 14.30 9.94~ A41 535 321 204 10 0.15 1.90 6.75 11.50 19.00 23.00 65.50 13.82 9.661 Women C75Cf 287 165 ',17 5! 0.10 1.10 6,50 11.00 19.00 22.00 50.001 12.27 8.561 Controls ~ 506 340~ 157 9 I 0.10 1.90 7,00 11.00) 19.00 22.80 57.50 13.91 9.311 All 7931 505 274 14, 0.10 1.50 6,50 /1.00 19.00 22.80 1 57.50 13.37 9.091 All C9SBf 375 220~152 6 0.10 1.45 ,50 11.00 6 18.50 22.00 50.00I 12.07 8.37) Controls 950 606~ 326 1 18 0.10 1.90 7,00 11.81 19.00 23.00 65.50I 14.08 9.581 AII 1324 828 478 24 0.10 1.65 6,50 11.00 19.00 22.80 65.50( 13.54 9.311 HOSPITAL BASED STUDIES Men , Cascf 47 18 29 0 1.05 7.50 10,88 17.00 19.00 21.00 36.7 5 16.07 7.35.f Controls 73 45 28 0 l 1.2 5 5.50 14.25 19.00 I 19.00 33.25~ 44.50 18.24 9.251 AII 120 63 57 0 1,05 7.50 13.13 19.00 19.00 30.00 44.50 17.62 8.741 ':'Cmen CaSC3 799 132 64 3 0.25 1.90 9.00 14.25 19.00 21.00 57.001 14.20 8.711 Conlrolf 379 271 101 71 0.50 1 2.50 9.50 15.00 19.00 23.00 45.00 15.07 8.361 Aq 5701 403 165 10 0.25 1.90 9.50 14.50 19.00 23.00 57.00 14.78 8.48) Atl CS:@; 246 ~150 93 3 0.25 1.90 9.50 14.38 19.00 21.00 57.00 14.43 8.55 Controls 452 316 129 7 0.50 2.75 10.00 17.50 19.00 23.00 45.00 15.52 8.55~ Afl 698 466 222 10 0.25 2.00 9.50 15.81 19.00 23.00 57.00 15.17 8.56 Men Cases 112 55 56 0.50 2.50 9.50 11.00 19.00 22.00 36.75 13.67 8.031 Controls 406~ 228 173 5 0.15 2.50 9.38 14.75 19.00 30.00 65.50 15.28 9.88I AII 518_ ~_ 283 229 6 0.15 2.50 9.38 14.25 19.00 27.00 65.50 14.96 9.56 Women C3;ef 430-~ _ "75 150 5 0.10 1,90 9.00 14.25 19.00 27.00 68.00 14.70 10.02; Conttolf 810 525 273 F 12 0.10 2.50 9.00 14.25 19.00 23.00 57.50 14.91 9.191, A!1 1240 800 423 17 0.10 1.901 9.00 19.00 25.25 68.00 14.83 9.47? AII CSSif i 542 330 205 6 0.10 1.90 9.50 13.50 19,00 26.25 68.00 14.53 9.711 Controls 1216 753 446 17 0.10 2.50 9.38 14.50 19.00 24.75 65.50 15.02 9.401 Al/ 1758 1083 652 23 0.10 2,25 9.38 14.25 19.00 25.50 58.00 14.87 9.491 Men C3fff 57 31 26 0 9.05 2.50 10.50 11.00 19.00 22.00~ 36.00 13.97 6.314 Controls 1721 100 72 0 0.15 2.05 10.06 15.25 19.63 35.75 54.25 16.80 11.381 ~~ AB 229 E 131 98 0 0.15 2.20 10.13 14.50 19.25 35.00 54.25~ 16.13 10.771 ... VY ICfnCn GaSQf 138 82 55 1 0.30 2.75 11.00 16.50 19.00 28.50 50.00 16.30 9.69i COr11f01f 254 159 91 A 0.10 1.90 9.50 17.00~ 19.00 26.00 43.50 15.33~ 8.831 All 392 241 146 I 5 0.10 2.50 10.50 16.50 19.00 27.00 50.00 15.66 9.12'. AN CiSQ; Controls All 195 426 621 '13 259 372 81 163 244 11 4i 5I i 0.30 0.10 0.10 2.50 1.90 2.20 10,88 9.50 10.50 14.50 16.30 16.28 19.00 19.00 19.00 28.00 30.00 28.50 50.00 54.25 54.25 95.66 15,90 15,83 9.35, 9.90 9.72 AGE 5544 YEARS Men CO;C3 COnlfOlf 52 25 26 1,45 1.75 6.501 11.00 14.50 19.00 26.50 90,80 6.29 216 118 92 6 0.80 1.90 7.15 13.45 19.001 22.50 65.50 14.08 9.72. All 268 i43 518 7 0.80 1.90 6.50 11.501 19.0021.00 65.50 13.51 9.28 WOmCn GSSC; 176 115 58 3 0.10 1.90 7 50 . 13.13 19,00 27.50~ 68.00 14.73 10.83 Gontrolf 359 250 102 7 0.10 1.88 6,75~ 16.50 1 9.00~ 26.00 45.00) 14.78 9.41 ~I 535 365~ 160 10 0.10 1.90 7.50 14.25 19.001 27.00 68.00( ~ 14.77 9.86 A11 GiSCf ~ 28 140 84 4 0.10 1,90 7,50 91.63 19.00 26.75 68.00 14,03 10.27 Controls 575 368 194 13 0.10 1.90 6.88 14.50 19.00 24.25 65.50 14.56 ~ 9.50 ~ All 803 508 278 17 0,10 1.90 7.08 14.25 19.00 25.50 68.00 14.41 9.71 AGE 65+ YEARS Men Ci3ef 48 20 28 0 0,50 1.93 7.50 15.00 19.00 19.00 36.75 13.63 8.62 Con1701f 192 117 72 3 0.30 1.90 9.38 17.50 19.00 23.00 43.00 15.30 9.23 All 240 137 100 3 0,30 1.90 9.38 17.50 19.00 22.80 43.00 15.06 9.13 Won1Cn Cases .'.36 947 85 4 0,25 1.10 6.50 14.25 19.00 22.00 56.00 13.50 9.31 Canlrots 483/ 3071 151~ 5 0,35 3.25I 11.00 15.50 19.00 25.63 57.50 15.53 9.21 All 599 454 236 9 0.25 1.90i 9.50 14.25 19.00 23.00 57.50 _ 14.87 _ 9.26 At/ CStf6f 284 167 113 4 0.25 1.10 6.50 74,25, 19.00 22.00 56.00 13.52 9.21 Controls 655 424 223 81 0,30 3.00 10.50 16.50! 19.001 24.75 57.50 15.46 9.21 All 939 591 336 12 0,25 1.90 9.50 15.20 19.00 23.00 57.50 14.91 9.24 2'J63593355

® S1CS Spouse, Cumulative exposure of smoking spouse (packs/day x years) lMEN ONL`f Lovs! of .xaoauro NE,, S1CS<35 35<S1C3<.52 Cases Controls OR(1) 95% CI OR(2) 95% CI ( OR(3) 95% CI OR(4) 95%. CI ; OR(5) 95'/. CI E 99 433 1.00 1.00 1.00 1.00 1.00 E 0 4 0.00 ( 0.00-99.99) 0.00 ( 0.00-99.99)~ 0.00 ( 0.00•99.99)( 0.00 ( 0.00-99.99)-0.00 ( 0.00-99.99) EXCluded/T/'and ~ 42~ 94 0.99 ~ € 0.99 ~ 0.99 0.99 0.99 WOMEN OMEN ONLY NE., S1C5<r35 251 584 1.00 1.00 1.00 1.00 1.00 35<$1C5<a52 34 72 1.14 ( 0.73- 1.79) 1.11 ( 0.69- 1.79) 0.98 1 0.56- 1.72) 1.21 ( 0.77- 1.90) 1.09 ( 0.65- 1.85) S2<S1C8 30 51 1.37 f, 0.84- 2.24) 1.14 ( 0.66- 1.97) 1.19 ( 0.63- 2.24) 1.41 ( 0.86• 2.31) 0.90 ( 0.48- 1.69) ExC1UdId/T/`andj 194 3041 0.18 0.16 [ B.1B 0.18 0.19 POPULATION BASED STUDIES NE., S1C5<35 165 35<S1CS<52 12 52<51CS 9 669 1.00 1.00 7.00 1.00 1.00 24 1.59 ( 0.75- 3.36) 1.69 ( 0.77- 3.72) 1.76 ( 0.71- 4.33) 1.71 ( 0.80- 3.65)i 2.66 { 0.94- 7.53) 27 0.91 ( 0.41- 2.03) 0.99 ( 0.44- 2.24) 0.82 ( 0.30- 2.19) 0.94 ( 0.42- 2.12)( 0.49 ( 0.15- 1.58) Excludad/TiYnd 192~ 230 0.62 0.63 0.67 0.61 0.63 ~ HOSPITAL BASED STUDIES NE., SiCS<35 ~ 35<81CS<52 52<SlCS Excluded/Trrnd 49i Excludad/Ti'sndi 18 YJiTHOUT OCCASIONAL SMOKERS NE., S1CS<.35 1.00 0.90 1.30 1.00 1.00 1.00 ( 0.50- 1.62) 0.82 ( 0.41• 1.67) 1.04 { 0.60- 1.82) 0.85 ( 0.46• 1.58) { 0.62- 2.75) 1.85 ( 0.78- 4.39) 1.87 ( 0.99- 3.54) 1.26 ( 0.59- 2.71) ~ ~ 0.10 236 694 1.00 1.00 1.00 1.00 1.00 35<S1CS<.52 22 61 0.86 C 0.50- 1.46) O.IIS ( 0.48- 1.52) 0.80 ( 0.42- i.55), 0.92 ( 0.54- 1.58) 0.71 ( 0.37- 1.38) E?,2<SiCS 21 ~ 41 1.19 ( 0.67- 2.11) 0.85 ( 0.44- 5.64) 0.90 ( 0.43- 1.85)~ 1.23 ( 0.69- 2.20) 0.67 ( 0.31- 1.43) Excludad/Trend~ 207 308 0.77 0.77 ! 0.78 ~ 0.77 0.83 AGE <55 Y€ARS NE,, S10S<35 35<S1CS<52 52<51CS Excludad/Trand~ AGE 55•8< YEARS NE.1 $1CS<e36 35<S1CS<52 52<SlCS Excluded/Trand AGE 65+ YEARS NB.r u1CS<35 35<51CS<52 52<51CS 185 22 21 1131 3 31 461 92 13 12 93 145 18 15 Excluded/Trand 971 HISTOLOGICALLY CONFIRMED DIAGNOSIS NE., 51CS<35 336 35<51CS<52 ( 33 52<S1CS Ilf 27 Excluded/Trvnd~ ~311 SQUAMOUS CELL CARCINOMA NE., $1C6<•35 50 35<S10S<52 6 52<S1CS 41 SMALL CELL CARCINOMA NE., y10S<35 ( 27 35<S1CS<w52 52<SlCS ADENOCARCINOMA N€„ S1CS<.35 36<S1CS<52 52ES1CS 5 Excluded/Trandl 371 285 13 6 57 1.00 0.48 1.38 0.65 ( 0.13- ( 0.28- 1.80) 6.72) 1.00 0.62 0.00 0.67 ( 0.16- ( 0.00•9 2.44) 9.99) 1.00 I 0.49 I 0.00 ~ 0.64 { 0.10• 2.56) ( 0.00•99.99)! ~ 1.00 ~ 0.51 1.44 0.65 ( 0.14- 1.94) ( 0.29- 7.07) I 1.00 0.40 3.88 0.65 ( ( 0.08• 1.99) 0.16-94.40) 356 19 13 1641 1.00 2.54 2.72 0.00 ( 1.14- ( 1.13• 5.69) 6.53) 1.00 2.23 2.21 0.00 ( 0.95- ( 0.85- 1.00 5.26)I 2.16 5.76) 3.12 f F ~ 0.00 1.00 ( 0.80- 5.84) 2.52 ( 0.96•10.14)! 2.67 F ~ 0.00 ( 1.12- 5.65) C, 1.11- 6.42) 1.00 1.99 1.90 0.00 ( ( 0.78- 5.06) 0.64- 5.61) 376 1.00 1.00 1.00 1.00 1.00 44 0.97 ( 0.53- 1.79) 0.95 ( 0.49- 1.81) 0.89 ( 0.41- 1.95) 1.06 ( 0.57• 1.97) 1.02 ( 0.51- 2.06) 32 1.05 ( 0.54• 2.06) 1.04 ( 0.52- 2.09)1 1.05 ( 0.47- 2.33) 1.09 ( 0.56- 2.15) 0.61 ( 0.27- 1.39) 1771 0.95 0.94 ~ 0.87 0.94 0.99 1017 1.00 I 1.00 1.00 1.00 1.00 76 1.13 ( 0.72- 1.77) 1.11 ( 0.69- 1.79) 0.99 ( 0.57• 1.73) 1.19 ( 0.76- 1.88) 1.10 ( 0.65- 1.84) 51 1.27 { 0.76- 2.10) ~ 1.05 ( 0.60- 1.85)~ 1.22 ( 0.65• 2.29) 1.30 ( 0.78- 2.16) 0.92 ; 0.49• 1.73), 398 0.28 0.27 ; 0.29 0.27 0.30 1017 1.00 1.00 1.00 I 1.00 1.00 76 1.33 (, 0.52- 3.43) 0.72 ( 0.21- 2.52) 0.27 (- 0.03• 2.09), 1.38 ( 0.53- 3.57) 0.79 0.22- 2.84) 51 1.32 ( 0.44• 4.01) 1.03 ( 0.29- 3.60) 1.24 ( 0.34- 4.59)] 1.34 ( 0.44• 4.07) 0.77 !, 0.17• 3.49) 398 0.39 0.40 0.42 0.40 0.42 1017 1.00 1.00 1 00 ! 1 00 1 00 76 1.98 ( 0.67- 5.83) 1.61 (, 0.48- 5.37) 2.29 ( 0.62- 8.48)1 2.03 ( 0.68• 6.07)! 2.24 ( 0.70- 7.16) 51 0•28 ( 0•03• 2.26) 0.29 ( 0.03- 2.38) 0.35 ( 0.04- 3.15) 0.26 ~ ( 0.03- 2.15)I 0.00 ( 0.00-99.99) 3981 0.89 0.83 ~ 0.79 t 0.90 ~ 0.86 787 1017 1.00 1.00 1.00 1.00 1.00 17 76 I 1.05 ( 0.59• 1.88) 1.17 f, 0.65- 2.11)) 0.94 { 0.46- 1.94) 1.13 ( 0.63- 2.01) 1.05 ( 0.55- 2.02) ! 15 51~ 1.30 ( 0.70. 2.42)~ 1.00 ( 0.48- 2.09)) 1.13 ( 0.49- 2.59) ! 1.34 ( 0.72- 2.51) 0.86 ( 0.38- 1.94) ~ Excludrd/Trand 114 398 0.43 EE 0.42 ~ 0.46 ~ 0.44 ~ 0.46 OTHER NE., 51C6<35 35<S1CS<52 .ri2<S1CS 72 S Excludad/T/Yndf 31! 1017 1.00 1.00 1.00 1.00 1.00 76 0.84 ( 0.31- 2.23) 0.91 ( 0.34- 2.46)I 1.05 ( 0.38- 2.91)1 0.90 ( 0.34- 2.41) 0.91 ( 0.30- 2.78) 51 1.71 ( 0.72- 4.09) 1.58 ( 0.62• 4.04) 1.91 ( 0.67- 5.48)) 1.78 ( 0.74- 4.26) 2.13 ( 0.80- 5.69) 3981 0.44 ~ 0.44 ~ 0.46 I 0. 42 0.44 >75'h OF UFESPAN IN RURAL AREA OR INTERMEDIATE CITIES NE., S1CS<.35 1 89 270 1.00 35<$1CS<.S2 11 21 1.20 ( 0 52<S1CS B 14 1.67 ( 0 1.00 1.00 1 00 . 1.00 .53• 2.74) 1.20 ( 0.53• 2.74) 1.18 0.42- 3.29) 1. ( I29 ( 0.56- 2.95) 1.00 ( 0.41- 2.47) .63- 4.39) 1.67 ( 0.63• 4.39) 2.71 0.79- 9.31) 1.77 0.67- 4.70) ( !!!f ( 1.15 ( 0.37- 3.57) Exclbdid/Trand 148 2701 0,24 ~ 0.24 1 0.20 1 0.25 0.23 a7556 OF LIFESPAN IN URBAN AREA NE., 51C5<35 147 537 - 1.00 1.00 1.00 1.00 1.00 35<S1CS<r52 17 43 1.16 ( 0.62- 2.19) 1.16 ( 0.62- 2.19) 1.14 ( 0.56- 2.33) 1.25 ( 0.66- 2.38) 1.23 ( 0.57- 2.63) ~ 52<SlCS 13 32 1.14 ( 0.56- 2.31) 1.14 (, 0.56- 2.31) 1.08 ( 0.48- 2.43) 1.13 ( 0.55- 2.29) 0.93 ( 0.39- 2.20) ExClttdad/Trand 67 99 0.57 E 0.57 I 0.57 1 0.56 [ 0.59 (1) Model irxlude sex, cen(er, sex'cen(er and age (2) ModN Include sex, center, sex'center, age and proportion of residential type in the last 35 yrs (REUP) (3) Mede1 Mc/ude 3ex, center, sex'cen(er, age, proportivn of res~dentia/ type in the tast 35 yrs (REtlP) and educauonal level (EDUC) (4) Model indude sex, center, sex-ccnter, age and duration of exposure to list A agents (OCLAY) (5) Model Include sex, center, sex'center, age and freauency consumotion pf ve e!ables N- ;E)

E_S1TP Spouse, exposure to different tobacco products MEN ONLY taqat o( p o. Gsns ( Coatrots O(1) 55% C1 Non ex s@tl 118 462 t.00 Onl ci arette 22 65 1-47 0.80- 2.70)1 Excludid/Trsnd WOMEN ONLY 4 OR(2) 95% CI OR(3) 95% Cl 1.00 1•00 1.58 ( 0.82- 3.04) 1.08 ( 0.44- 2.66) (p € OR(4) 95'.Cl ~ OR(5) 95%Cf ~ 1.00 t.00 ~ 1.46 (, 0.79• 2.69)~ 5.52 ( 0.77- 3.00)i Non exposed Only cigarette 187 239 376 453 1.00 ( 1.05 ( 0.82- 1•35) 1.00 1.04 (, 0.80- 1.37) 1.00 1.02 ( 0.75- 1.39) 1.00 t.07 (, 0.83- 1.38) 00 0•97 ( 0.73- 1.31) Hever cigarotte 12 27 0.81 (, 0.39- 1.66)~ 0.61 ( 0.28- 1.35) 0.63 ( 0•27- 1.47) 0.90 ( 0.43- 1•87) 0.83 ( 0,40- 1.72) Cigarette + other 40 58 1.23 ( 0.78- 1.95) 1.24 ( 0.77. 1.99) 1.17 ( 0.67- 2.05) 1.23 ( 0.77- 1.96) 1.20 ( 0.74- 1.95) E.rcludtd/Trend 31 97 ~ ) POPULATION BASED STUDIES Non oxposed 186 577 1.00 1.00 1.00 1.00 1.00 C Only SQafatte 53 1 7 31 1.08 { 0.80• f.45) 1.11 ( 0.82- 1.51) 1.10 ( 0.77- 1.57) 1.11 ( 0.82- 1.49) 1.16 ( 0.82- 1.62) Never cigarette 7 13 0.79 ( 0.30- 2.08) 0.72 ( 0.26- 1.99) 0.77 ( 0.25- 2.37) 0.89 ( 0.33- 2.37) 0.88 ( 0•33- 2.35) + other Cigarette 31 41 1.25 ( 0.73• 2.15) 1.30 ( 0.75- 2.25) 1.26 ( 0.66- 2.41) 1.25 ( 0.72• 2.15) 1.33 ( 0.75- 2.36) Ercludtd/Trandl 2 ~ ` HOSPITAL BASED STUDIES Non exposed 11 201 1.00 1.00 1•00 1.00 1.00 Only cigarette 1 08 201 1.16 ( 0.80. 1.69) 1.06 (, 0.68. 1.64) 0.96 ( 0.56- 1.64) 1.16 ( 0.79- 1.70) 0.89 ( 0.56- 1.39) Never cigaratte 5 14 0,90 ( 0.30. 2.66) 0.51 ( 0.14• 1.89) 0.55 ( 0.14- 2.14) 0.96 ( 0,32- 2.89) 0.77 ( 0.25- 2.32) Cigarette + other 91 17 1.33 ( 0.55• 3.19) 1.16 ( 0.46- 2.96) 1.06 ( 0.36- 3.14) 1.34 ( 0,56- 3.22) 1.13 ( 0.46- 2.75) Excludid/Trtndl WR)}Ollr OCCASIONAL SMO KERS 1d 19 Non exposad 225 593 1.00 1.00 1.00 1.00 1.00 Only cigarette 203 397 1.12 ( 0•85• 1.46) 1.11 ( 0.83- 1.48) 0.96 ( 0.69- 1.33) 1.14 { 0.86- 1.49) 1.00 ( 0.73- 1.37) Never cigarette 0 20 0,75 ( 0.31- 1.76) 0.57 ( 0•22- 1.a9) 0.59 ( 0•22= 1.57) 0.86 ( 0.35- 2.07) 0.74 ( 0.30• f.80) Cigarette + other 27 39 1.22 ( 0.70• 2.14) 1.14 ( 0.64- 2.03) 1.01 ( 0.54- 1.90) 1.21 ( 0.68- 2.13) 1.26 { 0.70- 2.27) Excludad/Trtnd a9 d5 j AGE t55 YEARS Non expoaed Only cigarette Never cigarette Cigarette + other Excludrd/Trand AGE 55•b4 YEARS 94 58 4 6 9 215 123 5 14 4 1,00 0•96 ( 1.42 ( 0,83 ( 0•61• 0•35• 0.29- 1.50) 5.79) 2.37) i 1•00 ~ 1.00 1.00 ( 0.61- 1.65)I 1.07 ( 1.09 ( 0.23- 5.13) 1.30 ( 0.94 ( 0•32- 2.76)I 0.88 ( E 0.59- 0.25- 0.24- 1.92) 6.69) 3.26) 1.00 0.94 ( 1.45 ( 0.87 ( 0.60- 0.36- 0.30- 1.49) 5.93) 2.49) ~ 1.00 1.03 ( 1.43 ( 0.77 ( 0.62- 0.35- 0.25- 1.73) 5.87) 2.41) E Non eXposed 98 309 1,00 1.0~ 1.00 1.00 1.00 Only cigarette 64 173 1•11 ( 0.73- 1.70) 0.95 ( 0.61- 1.50) 0.72 ( 0.43- 1.21) 1.15 ( 0.75- 1.76) 0.93 ( 0.56- 1.55) Never ciparatte i 4 10 0.98 ( 0.28. ~ 3.49) 0.69 ( 0.17- 2.78) 0.60 ( 0.15- 2.45) 0.98 ( 0.28- 3.46) 0.90 ( 0.25- 3.23) Cigarette + other 10 16 1.49 ( 0,60• I 3.70) 1.37 ( 0.55• 3.44) 1.26 ( 0.42• 3.78) 1.33 ( 0.52- 3.38) 1.44 ( 0.57- 3.67) e'xcludad/Trandl AGE65+YEARS 14 44 t HOn @XpOSe C 113 314 1.00 1.00 ' 1.00 1.00 1.00 Only cigarette 119 222 1.22 ( L 76) 0.84. 1.32 ( 0.89- 1.95) 1.37 ~ ( 0.85- 2.20) 1.24 ( 0.86- 1.81) 1.19 ( 0.78- 1.81) Never cigarette 4 12 0.53 ( 0.16- 1.74} 0.44 ( 0.12- 1.63) 0.40 !! ( 0.08- 2.00) 0.66 ( 0.19- 2.23) 0.59 ( 0.18- 2.01) Cigar@tta + other ~ 24 28 1.45 ( 0.77- 2.74) 1.49 ( 0.77- 2.89) 1.36 ( 0.63- 2.97) 1.50 ( 0.79- 2.83) 1.40 ( 0.71- 2.74) Excluded/Trtnd 15 53 1 ~ HISTOLOGICALLY CONFIRMED DIAGNOSIS Non exposed 296 838 1.00 1.00 1.00 1.00 T 1.00 Only cigaratte 251 518 1•07 ( 0.85- 1.36) 1.08 ( 0.84- 1.40) 1.05 ( 0.80- 1.43) 1.10 ( 0.87- 1.39)1 1.06 ( 0.81- 1.39) Never cigarette ~ 12 27 0.83 ( 0.40• 1.70) 0.63 ( 0.29- 1.40) 0.66 ( 0.28- 1.55) 0.92 ( 0.45- 1.92) 0.87 ( 0.42- 1.81) Cigarette + other 40 50 1.25 ( 0.79. 1.98) 1.26 ( 0.79- 2.02) 1.20 ( 0.69- 2.09) 1.26 ( 0.79- 1.99) 1.26 ( 0.78- 2.04) ~ c"xcluded/Trenc 28 101 t SQUAMOUS CELL CARCINOMA Non expOaeC 50 838 1.00 1.00 1.00 1.00 1.00 qnly cigarette 45 918 1.16 ( 0.71• 1.89) 0.95 ( 0.55- 1.62) 0.88 ( 0.48- 1.61) 1.14 ( 0.70• 1.86) 0.86 ( 0.48- 1.54) Never cigarette 1 27 0.41 ( 0.05- 3.19) 0.36 ( 0.05- 2.79) 0.47 ( 0.06- 3.83) 0.43 ( 0.05- 3.34) 0.36 ( 0.05- 2.82) Oigarette + other 6 58 1.24 ( 0.48- 3.20) 1.13 ( 0.43- 2.93) 1.07 ( 0.36• 3.14) 1.23 ( 0.48- 3.16) 1.15 ( 0.44• 3.02) Excludid/Trand 7 101! SMALL CELL CARCINOMA Non expGS@d 3S1 8361, 1.00 1.00 1 1.00 1.00 1.00 Only Cigarette ~ 28 518j 1.55 ( 0.83• 2.89) 1.55 ( 0.81- 2.98) 1.67 ( 0.82- 3.41) 1.58 ( 0.84- 2.98) 1.52 ( 0.79- 2.93) Never cigarett@ 111( 27I 0,64 ( 0.08- 5.19) 0.62 C 0.08- ~ 5.08) 0.80 ( 0.09- 6.74) 0.76 (, 0.09- 6.20) 0.64 ( 0.08- 5.23) Cigarette + other 6 58f 1.52 ( 0.54. 4.26) 1.29 ( 0.42- I 3.93) 1.45 ( 0.45- 4.65) 1.53 ( 0.55- 4.31) 1.51 ( 0.53- 4.28) txcludad/Trendl 41 1011 1 ADENOCARCINOMA @xpos@d 159 838 7.00 1.03 ( 0.77• Non Only CSQer@tt@ 138 5181 Never Cigar@tta 8 27 0.96 ( 0.41- Cigaretta + other 15~ 58 0.84 ( 0.45- ~ 1.00 !!! 1.00 1.00 1.00 1.38) 1.06 ( 0.77- 1.45)I 1.04 ( 0.72- 1.49) 1.06 ( 0.79• 1.43) 1.04 ( 0.75- 1.441 2.20) 0.75 ( 0.30- 1.90)I 0.74 ( 0.26- 2.04) 1.07 ( 0.46- 2.50) 1.00 ( 0.43- 2.32) 1.57) 0.85 { O.a4• 1.62) 0.72 ( 0.32- 1.59) 0.87 ( 0.47- 1.63) 0.78 ( 0.40- 1.53) Excludtd/Trrnd 13 ~ 101 ~ ~ OTHER Non exposed i 56 838 1,00 1.00 1.00 1.00 - - ~1.00 Only cigarette ~ 40 518 0.96 ( 0.59• 7.55) 1.08 ( 0.65- 1.81) 1.03 ( 0.57- 1.86) 0.99 ( 0.61- 1.62)1 1.08 ( 0.62- 1.89) ?lever clQaret:& 2 27 0.90 ~ 0.20- 4.07) 0.49 ( 0.06- 3.86) 0.55 ( 0.07- 4.40) 1.02 ( 0.22- 4.63) 1.07 ( 0.23- 4.89) Cigarette + other E 13 58 2.46 ( 1.18- 5.13)~ 2.68 ( 1.26• 5.69) 2.63 ( 1.07- 6.46)~ 2.36 ( 1.11- 5.03) 2.99 ( 1.38- 6.47) EXcludtd/Trendf 4 101 >75!4 OF LIFESPAN IN RURAL AREA OR INTERMED IATE CITIES Non expos@d 122 32 1 1.00 1•00 1.00 ~ 1.00 1.00 Only cigarette 99 15 3 1.21 ( 0.81- 1.82) 1.21 ( 0.81- 1.82) 0.92 ( 0.57- 1.49) 1.21 ( 0.81- 1.82) 1.03 ( 0.67- 1.58) Never cigarette 2 1 14 0.26 ( 0.06- 1.22) 0.26 ( 0.06- 1.22) 0.32 ( 0.07- 1.55) 0.27 ( 0.06• 1.27) 0.24 ( 0.05- 1.12) Cigarette + other 18 22 1.38 ( 0.67. 2.87) 1.38 ( 0.67- 2.87) 1.38 ( 0.61- 3.13) 1.35 ( 0.64• 2.83) 1.26 ( 0.60- 2.62) Excludrd/Trend 15 65f a75'i .75'. OF LIFESPAN IN URBAN AREA Non exposed 103 356 1•00 1.00 1.00 1.00 - I 1.00 Oniy cigarette 109 289 1.00 (, 0.70• 1.45) 1.00 ( 0.70- 1.45) 1.10 ( 0.72- 1.68) 0.99 ( 0.68• 1.43)1 1.11 ( 0.73- 1.70) Never cigarette 5 10 0.98 ( 0.31- 3.09) 0.98 ( 0.31- 3.09) 0.97 ( 0.27- 3.48) 1.25 ( 0.37- 4.17)1 1.23 ( 0.37- 4.07) Cigarette + other 1 17 28 1 1.20 ( 0.59- 2.42 ) 1.20 ( 0.59- 2.42) 1.07 ( 0.44- 2.57) 1.20 ( 0.60- 2.44)! 1.27 ( 0.59- 2.76) Exoludrd/Trend 70 20 ~ (1) Modef IncJudo sex, c@ntef, scx'center and age (2) Model indude sex, center, sex'center, age and proportion of residential type in the last 35 yrs (REUP) (3) Model tnrlude sex, c¢nter, sex'center, age, proponion of residential type in the last 35 yrs (REUP) and educational level (EDUC) r,'4) MOd01 irtc/Udc 6Cx, cINi(Cf, SCK'QGt1(cr, age and duratwn or exoosure to list A agen(s (OCLAY) (5) Model Indud@ sex, center, sex'center, age and frequency consumption of vegetables (VEGE)

S1DH Spouse, Duration (hours/day x years) ALL CENTERS Total Exoosed Unexposed Excfuded Min P10 01 1 Medlan 03 P P90 Max I Mean Std Men CESC3 138 21 116 5 i.60 3.43 12.00 38.50 66.00 102.54 190.57! 49.78 49.56 Controls 517 55 451 11 1.30 1 5.00 12.54 30.86 86.79 167.99 230.571 55.84 61.42 AII 672 76 567 29 1.30 4.00 12.27 31.43 74.59 145.71 230.57 54.16 58.13 WonSen Cases 486 229 181 76 0.10 11.00 28.93 93.00 173.89 296.68' 1216.00 128.15 135.26 COnt/0lD b85 475 327 83 0.15 10.00~ 31.71 71.25 140.43 233.14f 630.00 101.98 100.71 All 1520 704 508 308 0.10 10.61 30.00 80.07 152.39 252.32jj 1216.00 110.50 113.68 AIl CSSCS 650 250 297 103 0.10 10.02 27.43 89.04 169.71 281.21 1216.00 121.57 132.00 COntr01: 1542 530 778 234 0.15 8.96 27.96~ 64.75 135.14~ 222.64 630.00 97.19 98.35 All 2192 780 1075 337 0.10~ 9.00 27.91 70.98 149.30 240.54 1216.00 105.011 110.76, AND TYPE OF RESIDENCE Men C3505 89 11 78 0 3.00 10.85 17.25 32.00 62.00 66.00 102.54 39.09 30.25f COntroli 456 46 399 11 1.30 6.75 12.86 33.63 92.57 172.71 230.57 60.93 63.81 All 652 57 477 28 1.30 6.75 14.00 32.00 70.71 167.99 230.57 56.71 59.26 Women Cases 363 178 136 69 0.75 10.61 28.93 90.00 169.77 279.00 1216.00 123.25 136.83 Contto{i 742 410 254 78 0.19 12.68 33.43 77.14 150.57 240.54 630.00 106.56 104.38 All 1274 588 390 296 0.19 11.61 32.00 80.25 154.14 252.29 1216.00 '11.61 115.30 AlI C75C5 498 789 214 95 0.75 10.61 27.43 84.00 168.00 276.43 1216.00 118.35 134.40 € Controls 1338 456 653 229 0.19 10.86 30.00 69.29 144.86 233.141 630.00 101.96 101.91 € AIl 1836 645 867 324 0.19 10.85 28.93 74.29 150.57 <^40.00 1216.00 106.76 112.55 Men Cases 101 17 83 1 3.00 3.43 12.00 32.00 62.00 102.54 190.57 44.38 47.64 Controts 292 26 256 10 1.30 4.00 10.00 31.43 ~ 60.75 133.00 185.14 47.14 50.83 A}I 410 43 339 28 '..30 4.00 10.85 32.00 ~ 62.00 103.71 190.57 46.05 49.03 Wonlen C85CE 382 ',72 143 67 0.10 8.70 27.00 89.79 168.48 258.00 525.43+ 113.08 105.60 Cdtlirols 624 330 230 64 0.15 8.96 ~ 30.00 70.64 135.14 223.79 630.00( 1 100.24 102.83 Atl 1155 502 373 280 0.10 8.93 28.29 78.43 149.46 233.14 f 630.00 104.64 103.86 AJI CBSeL 509 189 226 94 0.10 7.50 23.68 82.14 160.71 257.14 525.43 106.90 103.56 Controls 1056 356 486 214 0.15 7.71 28.13 65.29 132.86 218.00 630.00 96.36 100.86 All 1565 545 712 308 0.10 7.71 27.00 70.71 138.75 228.57 630.00 100.02 101.83 FRANCE Men C85ef 14 1 13 0 32.00 32.00 32.00 32.00 32.00 32.00 32.00 32.00' 0.00 Control5 23 1 20~ 2 10.00 10.00 10.00 10.00~ 10.00 10.00 10.00 10.00I 0.00 AII 37 2 33 2 10.00 10.00 10.00 21.00 32.00 1 32.00 32.00 21.001 15.56 WOn1en CiSei 63 31 26 6 2.00 3.00 15.00 42.86 90.00 171.43 242.14 67.50 69.88 Controls 128 79 45 4 0.20 6.17 20.00 I 46.14 116.00 189.29 325.00 75.83 72.29 AA 191 110 71 10 0.20 4.79 20.00I 44.14 110.00 187.64 325.00 73.48 71.40 All CaSef 77 32 39 6 2.00 3.00 18.93 41.43 87.00 171.43 242.14 66.39 69.03 Conlrol9 ~ 151 80 65 6 0.20 6.841 19.50 45.21 115.50 187.64 325.00 75.00 7Z 21 Atl 228 112 104 12 0.20 5.001 19.50 43.50 109.00 186.00 325.00 72.54 71.11 GERMANYI Men Cases Controls All 18 129 147 3 9 12 15 113 128 0 7 7 17.25 6.75~ 6.75 17.25 6.75 12.54 17.25 19.29 42.75 56.25 18.27 44.95 41.25 70.71 65.73 41.25 41.25 185.14 185.14 167.99 185.14 25.93 72.22 60.65 13.31 62.91 57.87 Wanen Cases 58 24 /9 75 1.50 2.36 24.48 70.88 135.00 219.75 422.04 95.11I 100.31 COnU01S 100 50 40 10 1.50 25.83 42.75 79.07 102.54 146.91 561.75 92.51 91.90 AI! 158 74 59 25 1.50 18.601 38.891 77.57 105.00 168.00 561.75 93.36 94.02 AIl C41SeS 76 7 34 15 1.50 2.36 19.291 67.50 135.00 219.75 422.04 87.43 96.98 Controls 229 59 153 17 1.50 18.75 42.75 72.23 102.54 167.991 561.75 89.42 87.95 AII 305 86 187 32 1.50 12.54 34.29 70.981 104.68 168.001 661.75 88.79 90.31 GERMANY2 Men CeseS 29 4 25 0 3.00 3.00 5.92 38.42 84.27' 102.54 102.54 45.60 47.19 Controls 65 5 60 0~ 6.96I 6.96 30.89 54.64 86.79! 103.71 103.71 56.59 39.56 All 94 9 85 0I 3.00 3.00 10.85 54.64 86.79 103.71 103.71 51.71 40.64 Women CtsCS 113 55® ~ 41 17 0 75 11.57 23.14 100.29 157.71 258.00 443.57~ 113.13 100.4C COtltrol8 98 58 38 ' 2 1193 12.001 28.29~ 65.46 112.82 181.50~ 276.21 79.89 64.57 All 211 113 79 19 0.75 12.001 27.00 78.86 137.14 193.39 443.57 96.07 85.2' AlI Cases 142 59 66 17 0.75 10.85 21.21 89.57 150.00 258.00 443.57 108.55 98.9E Controls 183 63 98 2 1.93 !2.00 28.29 64.50 111.86 162.00 276.21 78.04 63.0= AJI 305 122 164 19 0.75 *1.00 24.64 73.07 135.00 188.04 443.57 92.79 83 .4E GERMANY3 Men Cases ` COf1Ua5 AN 10 0 10 0 ~ 14 1 13 0 12.86 12.861 12.86 12.86 12.86 12.86 12.86 12.86~ O.OC 24 1 23 0 12.86 12.86 12.86 12.86 12.86 12.86 12.86 12.86 0.0C WOtnen CSSe3 21 'b ~~ 12 3 6.07 6.07 93.00 117.32 130.18 279.00 279.00 123.82 88.5: Control5 i 38I 13 22 3 3.10I 6.00 9.29 56.25 82.54 114.75 252.32 63.97 67.1' All 59f 19 34 6 3.10 6.00 9.29 77.14 114.75 252.32 279.00 82.87 77.4- AlI et 31 CiS 6 22 3 6.07 6.07 93.001 117.32 130.18 279.00 279.00 123.82 88.5< Lj Controll 52 14 35 3 3.10~ 6.00 9.291 50.84 82.54 114.75) 252.32~ 60.32 65.9 A11 S3 20 57 6 3,10 6.04 11.07 66.80 111.59 191.25 279.00 79.37 77.0' I7ALY 1 Men Cases 9 0 58.57 58.57 58.57 58.571 58.57 58.57 58.571 58.57 0.0C COntr015 103 14 88 1 2.00 3.80 8.00 22.93 60.00 132.86I 172.71 46.71 54.3' Afl i11 15 95 1 2.00 3.80 8.00 25.00 0"0.00 132.86' 172.71 47.50 52_4: Women Cascs 32 18 9 5 18.75 30.00 42.43 61.00 131.14 360.00 1216.00 163.52 277.2 COntr0lt 118 77 35 6 0.19 12.00 32.00 84.86 151.141 266.00 480.00 109.80 . 106.3" Aq 150 95 44 11 0.19 15.14 33.00 79.71 - 151.14266.00 /216.00 119.98 153.22 AIl Cases 40 19 16 5 18.75 30.00 42.43 60.001 131.14 360.00 1216.00 157.99 270.4" COntrolb 221 91 123 7 0.19 10.00 25.00 62.14~ 138.29 252.29 480.00 100.09 102.4 AI( 261 110 139 12 0,19 11.14 30.00 62.00 132.86 258.79 1216.00 110.09 145.7 2J63593389

S1UD Spouse, Duration (years) (non overlapping) MEN ONLY Total Exposcd Unexposed Excluded Min ~ P10 fd1 Median 03 ~ P90 ~ Max Mean Std Men Ca56S 157 23 134 0 1.00 2.00 10.00 16.00 30.00 32.00 44.00 17.57 -12.1: Controls 580 68 510 2 2.00 5.00 8.00 16.00 26.50 40.00 44.00 18.31 11.9: AI1 737 911 644 2 1.00 4.00 8.00 16.00 28.00 35.00 44.00 18.15 11.S~ WOrtkn Cases 0 0 0 0 CCr1tICls 0 0 0 0 [ ~ AU 0 0 0 0 ~ ~ All CafEf 157 23 134 0 1.00 2.001 10.00 16.00, 30.00 32 . 00 44.00 17.67 12.1; Co!!trols 580 68 510 2 2.00 5.001 8.00 16.OOf 26.50 40. 44.00 18.31 00 17.9: AU 737 91 644 2 1.00 4.00 8.00 16.00i 28.00 35.00 d4.00 18.15 MCn Cases 0 0 0 0 ~ Con~olf 0 0 0 0 # AN o 0 0 0 E WOmCn CaSCS 550 316 215 19 1.00 4.00 14.00 26.50 36.00 43.00 54.00 25.18 13.6E Controls 1078 632 420 24 0.50 7.00 17.00 27.00 35.00 42.00 53.00~ 25.73 12.65 All 1626 948 635 43 0.50 6.00 15.00 27.00 36.00 43.00 54.00 25.55 12.9s All C95t3 550 316 215 19 1.00 4.00 14.00 26.50 36.00 43.00 54.00 25.18 13.6E Controls 1076 632 420 24 0.50 z°.00 17.00 27.00 35.00 42.00 53.00~ 25.73 12.65 A4 1828 948 635 43 0.50 6.00 15,00 27.00 36.00 43.00 54.0025.55 12.95 POPULA710N MCn C93Cf 91 - 16 75 0 1.00 2.00 4.00 12.75 26,00 34.00 44.00 16.22 13.11 Controls i44 60 383 1 2.00 I 5.00 ".00 15.50 25.00+ 34.00 1 44.00 17.40 11.3C AEl 535 76 458 1.00 4.00 8.00 15.00 25.001 34.001 44.00 17.15 11.62 Warcit C35¢S ae7 172 i11 4 1.00 4.00 14.00 25.50 35.00 42.00 54.00 24.811 13.5: Controls 506 309 194 3 1.00 6.00 16.00 25.00 33.00 42.00 52.00 24.53 11 12.3~ All 793 481 305 7 1.00 6.00 15.00 25.00 34.00 42.00 ! 54.00 24.63 12.77 AU Ca3ef 378 188 186~ 4 1.00 4.00 12.00 24.50 35.00 42.00 54.00 24.08J 13.65 COntroi.S 950 369 577 4 1.00 6.00 _ 14.00 23.00 32.00 41.00 52.00 23.37 12.4; All 1328 ?63 8 1.00 5.00 74,00 23.00 33.00 41.00 54.001 23.61 12.8' HOSAfTAL BASED STUDIES MG(1 S CaSQt 47 6 41 0 11.00 /1.00 16.00 23.50 31.00 32.00 32.00 22.83 9.21 Contro(f 73 5 68 0( 6.00 6.00 10.00 13.00 18.00 28.00 28.00 15.00 8.45 All 120 11 109 0 6.00 10.00 11.001 17.00 30.00 31.00 32.00 19.27 9.3- WOrt)tJ1 CBSCf 198 114 70 95 ':.00 3.00 14.00 26.50 37.00 43.00 52.00 25.39 13.8- Controls I 379 127 133 19 0.50 8.00 15.00 28.00~ 38.00( 43.00 53.00 26.42 13.Oe All 1 578 341 2031 34~ 0.50 6.00 15.00 27.00 37.00I 43.00 53.00 26.07 13.25 AN I:aSCS 246 '20 711 75 7.00 3.00 14.50 26.50 36.501 43.00 52.00 25.26 13.6C Controls ~ 452 232 201 19 0.50 8.00 15.00 27.50 37.00 43.00 53.00 26.17 13.0E A11 II 696 352 312 34 0.50 6.00 15.00 27.001 37.00 43.00 53.00 25.86 1 3.21 WITHOU7 OCCASIONAL SMOKERS MCn CasCS '.12 17 95 0 1.00 2.00 10.00 14.00 24.00 31.00 32.00 16,09 10.3( t Controls 406 48 357 1 2.OOI 6.00 11.50~ 18.50 30.00 41.00` 44.00 21,00 11.9E All 518 65 452 1 1.001 6.00 10.00 17.00 28.00 39.00 44.00 19,72 11.6 ` WCRtn CaSCS 430 240 173 17 1.00! 5.50 15.00 28.00 37.00 43.00 54.00 26.14 13.6 ~ Conud3 810 461 326 23 1.00 8.00 18.00 28.00 36.00 42.00 53.00 26.40 12.6 . A~1 1240 701 499 40 1.00 7.00 17.00 28.00 37.00 43.00 54.00 26.31 12.9' AA CasCS 642 257 268 17 1.00 4.00 14.00 27.00 37.00 43.00 54.00 25.48 13.7% COiltfGf 1216 509~ 683 24i 1.00 8.001 17.00 27.00 36.00 42.00~ 53.00 25.89 7758 766~ 951~ 411 1.00 7.001 16.00 27.00 _ 36.001 43.001 54.001 1 25.75~ 12.9' BASED STUDIES AGE tS3 YEARS h1tM l C9SCf 57 , 10 47. 0 1.00 5.50 11.00 13.75 1 23.00 26.00 28.00 15.251 8.0: 172 Controls AI! 229 26I! 361 145 192 1 1 2.00 1.00 5.00 5.00 8.00 9.00 13.50 13.50 19.00 19.50 24.00 24.00 29.00 29.00 13.62 14.07 7.1` VJamsrt C85Cf 38 67 69 2 1.00 3.00 8.00 17.00 25.00 31.00 37.00 16.61 10.2 ! Controls 254 128 119 0.50 5.00 11.00~ 19.00 25.50 30.00 39.00 18.10 9.0 ' All 392 195 188 9 0.50 4.00 10.00 19.00 25.00 30.00 39.00 17.59 9.4 All CaSCt 195 77 116 2 1.00 3.00! 9.00 16.00 24.00 30.00 37.00 16,44 9.9 Controls ~ 426 154 264 8 0.50 5,00 10.00 18.00 24.00 29.00 39.00 17.34 8.9 lAll Ill 621 231 380 10 0.50 4.00 10.00 17.00 24.00 29.00 39.00 17.04 9.2 AGE 55-64 YEARS MCO C~43Cf 52 7 , d5 0 2.00 2.00 4.00 16.00 32.00 34.00 34.00 18.43 13.7 Controls 216 /8 I 198 0 5.00 6.00 10.00 17.00 25.00 32.00 33.00 17.22 9.C All 268 25 243 0 2.00 5.00 10.00 76.00 26.00 32.00 34.00 17.56 10.< WOfi~ a SCf 176 101 68 71 2.00 8.00 18.00 28.00 35.00 39.00 46.00 25.50 12.C Controls 359 218 132 9 1.00 6.00 17.00 27.00 33.00 39.00 45.00 24.75 11-1 I Af1 535 319 200 16 1.00 6.00 77.00 27.00 34.00 39.00 46.00 24.99 11.4 AA CiSEf 228 108 `,13 7 2.00 4.001 16.50 28.001 35.00 39.00 46.00 25.05 12.Z Controls 675 236 330 9 1.00 6.001 15.00 26.001 33.00 38.00 45.00 24.17 11.2 Alt 803 344 443 16 1.00 v.00 '5.50 27.00 34.00 39 .00 46.00 24,45 11.E AG E 65+ YEARS h/C>1 G25C5 48 6 Controls ~ 192 24 AIl i 240 30 42 167 209 0 1 2.00 2.00 2.00 2.00 4.00 4.00 4.00 8.00 8.00 22.00 26.50 26.50 31.00 40.00 40.00 44.00 43.00 43.00 44.00 44.00 44.00 20.83 24.21 23.53 16.' 15.° 15.E WCmCf: CaSCS a 236 148 78 10 1.00 5.00 18.50 31.00 41.00 46.00 54.00 28.84 14.~ Controls ~ 463 286 ~ 169 I 8 1.00 10.00 20.00 31.00 42.00 46.00 $3.00 ~ 29.89 13.~ All ! ®99 434 247 ! 18 1,00 9.00 20.00 31.00 42.00 46.00 54.00 29.53 13.E AII GiSCf 284 154 120 10 1.00 4.00 ?7.00 30.50 41.00 45.00 64.00 28.53 14.E Controls 855 310 336 9 00~ 1 9.00 20.00 31.00 42.00I 45.50 $3.00 29.45 !A7/ 939 464 456 19 : 1 00+ 8.00 19.00 31.00 41.00f 45.00 $4.00 29.15 13.f

GJ_v fJ V U Spouse, Cumulative exposure (packs/day x years) ALL CENTERS a" atot arpesa:a 1 1 Gses Controls ORt11 95'>; Ct OR(2) 95•l. CI OR(3) 95% Cl ( OR 4 95'. CI ( OR(5j 95% CI NE.r .i1CU<13 485 1189 1.00 1 1.00 1.00 1.00 1.00 93<51CU<23 36 83 0.78 ( 0.48- 9.25) 0.49 ( 0.27- 0.86) 0.89 ( 0.58- 1.37) 0.93 ( 0.60• 1.43) ~ E 0.70 ( 0.42- 1.15) 23<S1CU 42 55 1.64 ( 1.05- 2.54) 1.53 ( 0.97- 2.43) 1.48 ( 0.89- 2.45) 1.66 ( 1.07- 2.58) 1.54 ( 0.92- 2.58 ) EX C l u dad / Trlnd Cludad/Trlnd 8T 215 0.09 E 0.09 1 0.08 ( 0.08 ~ 0.09 ~ ALL CENTERS WITH EDUCAT IONAL LEV EL AND TY PE OF RESIDENCE NE.t S1CU<13 308 846 1.00 1.00 1.00 13<S1CU<.23 16 66 0.48 ( 0.27• 0.87) 0.48 ( 0.27- 0.87) 0.49 ( 0.27- 0.88) 23<S1CU 31 45 1.47 ( 0.89- 2.43) 1.47 ( 0.89- 2.43) 1.48 ( 0.89- 2.45) 1.00 1.00 0.51 ( 0.28- 0.91) 0.46 ( 0.24- 0.86) ~ 1.49 ( 0.90- 2.47) 1.66 ( 0.95- 2.90) ExCluded/rrsndl 143 38f 0.92 0.91 0.89 0.91i 0.94 ; ALL CENTERS WITH DIETARY DATA N5.' SiCU<.13 13<S1CU<23 23<S1CU 370 743 1.00 1.00 t 1.00 1.00 1.00 g 25 65 0.71 ( 0.43- 1.18) 0.74 ( 0.44- 1.23)I 0.46 f• 0.24- 0.88) 0.75 ( 0.45- 1.23) 0.70 ( 0.42- 1.15) 31 39 1.53 ( 0.91- 2.56) 1.62 ( 0.96- 2.72)~ 1.69 ( 0.96- 2.96) 1.55 { 0.92- 2.59) 1.64 ( 0.92- 2.58) Exc1 udad/Trendl 83 2091 0.53 0.54 E 0.52 0.51 y 0.55 I 1 FRANCE NE., S1CU<13 13<S1C1.1<23 23<S1CU 63 124 1.00 1.00 € 1.00 ?.00 1.00 pppp 6 16 0.82 ( 0.30- 2.24) 1.03 ( 0.36- 2.89) 0.32 ( 0.04- 2 74) 0.83 ( 0.30- 2.27) 0.81 ( 0.29- 2.21)~ 4 8 1.12 ( 0.32- 3.99) ~ 1.12 ( 0.30- 4.19) 2.63 ( 0.53•12.96) 1.13 ( 0.32- 4.01) 1.16 ( 0.32- 4.13) Excl+rded/Trtnd 4 3 0.96 0.97 [ 0.96 ( 0.94 ~ 0.97 ~ GERMANY 1 NE., 1CU<r13 13<S1CU<23 23<S1CU 5'xc1 uded/Trend GERMANY2 NE.t ~S7CU<r13 13<$1CU<23 '.3<81CU sxcludsd/Trend GERMANY 3 2 NE., SiCU<13 29 49 13<S1CU<23 0 1 23<S1CU Excluded/Trnnd 1 1 r ITALY I 1,1E,r S1CU<1113 13<S1CU<23 23<SiCU 1.00 1.00 1.01 ( 0.24- 4.25) 0.76 ( 0.14- 4.10) 1.84 ( 0.57- 6.01) 1.74 ( 0.52- 5.88) 00 0.49 ( 0.17- 1.38) 0.86 ( 0.28- 2.64)I 0.41 1,. 00 0.00 ( 0.00-99.99) 1.92 ( 0.11-34.79) 0.88 1.00 ~ 1.00 € 0.52 ( 0.18- 1.48) 0.51 ( 0.18- 1.46) 0.83 ( 0.27- 2.57)1 0.87 ( 0.28- 2.74) 0.39 ~ 0.43 1.00 ) 1.00 0.00 ( 0.00-99.99) 0.65 ( 0.00-99.99) 1.54 ( 0.07-32.17) 1.31 ( I 0.06-28.17) . 091 t 0.86 1.00 E 1.00 1.03 ( 0.24- 4.37) 0.94 ( 0.22- 4.09) 1.89 ( 0.58- 6.17) 1.86 ( 0.56- 6.18) 0.34 ( 0.39 1.00 1.00 0.49 t, 0.17- 1.39) 0.50 ( 0.17- 1.42) 0.86 ( 0.28- 2.64) 0.86 ( 0.28- 2.66) 0.41 ~ 0.41 0.88 32 192 1.00 1.00 1.00 1.00 t 2 9 0.88 ( 0.17. 4.47) 1.02 ( 0.20- 5.23) 0.94 ( 0.18- 4.97) 0.93 ( 0.18- 4.72) 21 7 1.15 ( 0.22- 6.09) 1.37 ( 0.25- 7.39) 1.30 ( 0.24- 7.09) 1.20 ( 0.23- 6.37) fxcluded/Trendl 41 131 0.94 0.83 € 0.83 ~ 0.95 E ITALY 2 HE,t S1CU<13 13<S1CU<23 23<S1CU 16 156 1.00 1.00 1.00 1.00 E 0 6 0.00 ( 0.00•99.99) 0.00 ( 0.00-99.99) 0.00 ( 0.00-99.99) 0.00 ( 0.00-99.99) I ~ 2 6 1.78 ( 0.31•10.34) 2.39 ( 0.39-14.65) 2.19 ( 0.17-27.77) 1.93 { 0.33-11.39 ) ' ExoludedI rrend y S 0.77 0.53 0.56 0.79 ~ ITALY 3 E,t 51CU<.13 10 N 29 1.00 1.00 1.00 1.00 1.00 ~ 13<S1CU<23 3 9 0.59 ( 0.12• 2.89) 0.84 ( 0.14• 4.96) 0.48 { 0.06- 3.71) 0.63 ( 0.13- 3.12) 0.78 ( 0.14- 4.28) 23<S1CU 1 21 0.98 ( 0.07-13.99) 1.49 { 0.07-29.90) 99.99 ( 0.00•99.99) 1.05 ( 0.07-15.34) 99.99 ( 0.00-99.99) €xcludsd/7rsnd l 2 101 0.69 1 0.77 0.70 0.76 0.64 PORTUGAL 1 ~E N.t 51CU<.13 38 36 1.00 1,00 13<S1CU<23 i 5 2 3.89 ( 0.64-23.57) 3.74 { 0.63-22.25) 23<S1CU E SI 0 99.99 ( 0.00•99.99) 99.99 ( 0.00•99.99) @xcludsd/Trondl 11 1 1 0.02 ~ 0.02 PORTUGAL2 NE., S1CU<.13 13<S1CU<.23 23<S1CU 24 49 1.00 1.00 1.00 4 0 99.99 ( 0.00-99.99) 99.99 ( 0.00-99.99)1 199.99 ( 0.00-99.99) I 2 1 5.42 ( 0.40-73.95) 6.12 { 0.40•93.40)1 5.90 ( 0.44-79.46) E €xcluded/Trsndl 3 3 0.04 0.02 ~ 0.04 SPA1N NE,t S10U<13 13<S1CU<.23 23<S1CU 43 98 1.00 1.00 1.00 7.00 1.00 2 19 0.25 ( 0.06- 1.16) 0.28 ( 0.06- 1.28) 0.27 ( 0.06- 1.28) 0.29 ( 0.06- 1.36) 0.26 ( 0.06- 1.18) 9 15 1,51 ( 0.59• 3.86) 1.67 ( 0.63• 4.43) 1.71 ( 0.64- 4.61) 1.50 ( 0.59- 3.66) 1.63 ( 0.62- 4.23) cxclud9d/Trend 17 27 0.85 0.88 0.90 0.82 0.74 SWEDEN NE., S1CU<13 60 108 1.00 1.00 € 1.00 1.00 13<S1CU<g3 F 5 3 3.35 ( 0.73-15.31) 4.08 ( 0.85-19.44) 1 3.49 ( 0.77-15.89) 3.24 ( 0.70•14.95) 23<S1CU 3 1 6.21 ( 0.6D•64.22) 6.37 ( 0.60-67.92) ~ 6.37 ( 0.62-65.57) 7.34 ( 0.70-77.35) f Exclud.d/Trend 2 OI 0.04 0.03 0.04 0.03 UNITED KINGDOM f i ~ ~ -- - --- ~ ~ r~i --i- -- -- ~~~`0 j7 Excluded/Trsnd 26 140 (1) Madel indudo sex, center, sex'cen;er and age (2) Model include sex, center, sex'eenter, age and proportion of resldential type in the Last 35 yrs (REUP) (3) Model indude sex, center, sex'ccnter, age, praportion of residential type in the fast 35 yrs (REUP) and educational level (EDUC) %d) Medel/ndtdo aex, cOnter, sex•eenter• age and duration of exposure to list A agents (OCLAY) . (5) Model InGude sex, center, seti'center, age and frequency consumpllon of vegetables (VEGE) Risk estimates - Spouse

S1 DH Spouse, Duration (hours/day x years) HHSTOLOGICALLY CONFIRMED DIAGNOSIS I Total I Exposed Men C3Se! 149 21 127 1.60 3.43 12.00 38.50 66.00 1 02.54 790.57 1 49.J8 49.56 CenttOis 566 55 499 1.30 5.00 12.54 30.86 86.79 167.99 230.57 55.84 61.42 All 732 76 ~_1,30 4.00 12.27 31.43 74.59~ 145.71 230.57 54.16 58.13 WOn1M CeSes 613 233 205 0.10 11.00 28.00 90.00 70.00 283.43 170.00 1216.00 124.54 134.10 950 494 371 0.05 9.29 31.43 71.34 740.00 233.14 630.00 101.72 100.61 At! 1607 727 576 0.05 10.29 30.00 78.86 151.71 250.71 1216.00 109.03 112.85 All CSSCS 883 254 33 2 0.10 10.61 27.00 83.52 168.00 276.43 1216.00 118.36 130.80 COnU01s 1658 S49 870 0.05 1 8.36 27.96 65.00 ~ 135.14 222.86 630.00 97.12 98.33~ All ~'.338 803 ?202 0.05 334 9.00 27.43 70.00 145.711 239.57 1216.00 103.84 110,01 SQUAMOUS CELL CARCINOMA Men C1.e3 28 1 27 0 90.00 90.00 90.00 90.00 90.00 90.00 90.00 90.00 0.00 Controls 566 55 499 12 1.30 5.00 12.54 30.86I 86.79 167.99 230.57 55.84 61.42 All 608 56 526 26 1.30 5.00 12.70 30.86 88.39 167.99 230.57 56.45 61,03 1Nertlen C85es 91 43 35 13 2.36 10.61 22.18 88.50 215.00 272.00 510.00 132.18 127.98 COOtr018 950 494 371 85 0.05 9.29 31.43 71.34 140.00I 233.14! 630,00 101.72 100.61 All 1173 537 406 230 0.05 9.43 30.00 72.23 150.00 241.07I 630.00 104.16 103.26 AH C9sOs 125 44 62 19 2.36 10.61 22,66 89.25 213,36 272.00 510.00 131.22 126,64 Controls 1656 1 549 870 237 0.05 8.36 27.96I 65.00i 135.14 222.86 630.00 97.12 98,33~ All 1781 593 932 256 0.05 9.00 27.75 66.OOI 140.00 232.57 630.00 99.65 100.97 SMALL CELL CARCINOMA Men Cases 13 2 11 0 17.25 17.25 17.25 39.63 62.00 62.00 62.00 39.63 31.64 COnUCls 668 55 499 12 1.30 5.00 12.541, 30.86 86.79 167.99 230.57 55.84 61.42 All 594 57 510 27 1.30 5.00 12.861 30.86 70.71 167.99 230.57 55.27 60.54 WOfnM Cases 82 27 25 10 0.75 5.00 11.00 46.29 146.25 180.00! 276.43 80.95 79.50 Controls 950 494 371 85 0.05 9.29 31.43 71.34 140.00 233.14~ 630.00 101.72 100,61 All 1143 521 396 226 0.05 9.00 29.71i 71.25 140.00, 228.57~ 630.00 100.64 99.67 AII asEt 81 29 36 16 0.75 5.00 /3.39 46.29 138.75 180.00 276.43 78.10 77.58 CO~1tr01s All 1866 1737 549 578 870 906 237 253 0.05 0.05 8.36 8.00 27.96 65.00 27.001 64.461 135.14 222.86 630.00 135.14~ 222.43 630.00 97.12 96.17 98.33~ 97.43 ADENOCARCINOMA MCO CaSet 79 13 65 1 3.00 3.43 10.85 38,50 78.46 140.861 190.57 53.751 59.29' CCnUplt 566 55 499 121 1.30 5.00 12.54 30.86 86.791 167.99~ 230.57 f 55.84! 61.42 A11 680 68 564 281 1.30 4.00 11.43 30.86 82.631 167.99 230.57 I 55.44i 60.59 Women C3Sef 277 122 115 40 2.00 15.75 32.00 92.21 170.141 300.43 1216.00 131.83) 152.09 Controls 950 494 371 851 0.05~ 9.29~ 31.43 71.34 140.001 233.14~ 630.00 101.72 100.61 A1J 1357 616 486 2551 0.05I 11.00 31.57 77.14 150.00 242.14 1216.00 107.68 113.18 All CiSCf 361 135 180 462.00 11.57 28.93 84.74 168.96 296.68 1216,00 124.31. 147.43 CenU01f 1656 549 870 2371 0.05 8.36 27.96 65,00 135.14 222.86 630.00 97.121 98.33 AIl 2017 684 1050 283 0.05 9.00 28,00. 68.00 140.00 232.00 1216.00 102.491 110.18 MCn C7sCf i 29 5 24 0 1.60 1.60 19.291 32.001 58.57 66.00 66.00 35.49 26.86 Controls I 566 55 499 12 1.30 5.00 12.54 30.86~ 86.79 167.99 230.57 55.84 61.42 A11 I 610 60 523 27~ 1.30 4.50~ 12.70 30,86 68.36 156.85 230.57 54.14 59.45 VYOfiCn C7sCs i 83 41 301 12 0.10 18.86 35.36 100.57 168.00 308.00 422.04 523.53 107.27 Controls I 950 494 371~ 85 0.05 9.29 31.43 71.34! 140.00 233.14j 630.00 101.72 100.611 All ` 1182 335 4011 226 0.05 10.00 31.43 74.29 144.00 237.71~ 630.00 103.39 101.20 AU 5et ;16 C9 46 54 16 0.10 14.69 30.86 86.07 144.861 308.00 422.041 113.96 105.17 Controls 1656 549 870 237 0.05 8.36 27.96 65.00 135.141 222.86~ 630.001 97.12 98.33 All 1772 595 924 253 0.05 8.93 28.00 66.00 136.711 227.141 630.00 98.42 1 98.89 >75x OF LIFESPAN IN RURAL AREA OR INTERMEDIATE CITIES Men C7504 73 S 67 ' i2.001 Controls H 212 01 9 4 1 200 3 5.00 ! ~ 267 20 5.00 f 12.001 5.00I .96f 5 19.29 18.29 78.29 32.00 54.64 35 .25 38.50 86.79 6.79 190.57 230.57 90.57 190.57 230.57~ 30.57 58.47 75.44 9.38 74.57 80.45 5.93 WOrt~Cn C85E3 a2o loo 92 2~~0.7s 9.65 23.41 81.00 160.86 285.64 525.43 111.94 114.58 Centfel3 361 180 160 21 0.05 7.21~ 25.29! 56.26 108.29~ 172.14 378.00 76.37 71.68 AIf 898 280 2521 167 0.05 8,18 24.75 58.92 125.79 202.86 525.43 89.07 90.81~ Afl C2;6s 313 105 49 ® 1591 0.75 10.61 23.14 74.25 157.71 279.001, 525.43 109.39 /13.33 COnUWs 867 189 ! 360~ 138 0.05 6.43 24.861 56.25 108.00~ 181.50 378.00 76.33 71,89 AIl 1000 2941 87 6191 1 0.05 8.00 24.00 57.75 125.36 200.00 525.43 88.14 90.75 >75!i OF LIFESPAN IN URBAN AREA Men CB:et 46 12 36 0 3.00 4.00 14.05 48.631 64.00 78.46 102.54 43.10 32,45 Controls ! 257 37 216 4 1.30 4.00 12.86 30.86 92.57 145.71 202.50 54.83 58.84 Atl 305 49 252 4 1.30 4.00 12.86 32.00 66.00 133.71 202.50 51.96 53.52 W6mCn CiSes 193 95 67 31 0.10 14.69 30.86 119.57 193.71 283.43 1216.00 138.36 154.61 Controls I 435 ~ 249 135 51) 0.15` 11.57 34.00 85.89 154.29 254.57 630.00 114.83 111.41 All 650 344 202 104 0.10 12.00 34.00 89.79 167.86 265.29 1216.00 121.33 125.05 Atl C,Z ef ef 244 107 103 34 0.10 11.57 28.36 90.00 173.89 276.43 1216.00 127.58 149.06 Controls 711 286 351 74 0.15 10.001 30.00 76.71 151.14 248.57 630.00 107.07 107.92 AA 955 393 454 108 0.10 10.29 28.93. 81.00, 155.00 252.29 1216.00 112.68 120.66 ~ Max Mean ~? ~363593392

'GI_v /P'1.Y Spouse, Average exposure (cigaretfes/day) t>dEN ONLY LeV\I Of exposUre Cases i Controls OR(1) 95%. CI OR 2) 95 : CI OR(3 95% CI OR(4) 95% CI OR(5) 95% CI ~ Non axposatl 116 S51 1.00 1.00 1.00 1.00 1.00 0<S1AV<10 22 51 1.85 ( 0.98- 3.49) 2.01 ( 1.01- 3.98) 1.48 ( 0.57- 3.83) 1.84 ( 0.97- 3.49) 1.97 ( 0.96- 4.04) 10tSiAVeib 0 4 0.00 ( O.OO-99.99) 0.00 ( 0.00-99.99) 0.00 ( 0.00-99.99) 0.00 ( 0.00-99.99) 0.00 ( 0.00•99.99) 18<StAV 0 ~ 3 0.00 ( 0.00-99.99} 0.00 ( 0.00-99.99) 0.00 ( 0.00-99.99) 0.00 ( 0.00•99•99) 0.00 ( 0.00-99.99) €xcludad/Tnnd 3 1 22 0.74 0.83 0.80 0.73 1 0.74 WOMEN ONLY Non exposad 181 327 1.00 1.00 1.00 1.00 1.00 O<S1AV< 10 164 360 1.00 ( 0.77- 1.31) 0.99 ( 0.75- 1.32) 0.96 ( 0.69- 1.33) 1.03 ( 0.79• 1.35) 0.96 ( 0.71- 1.30) 10<S1AV<18 25 79 0.57 ( 0.34- 0.93) 0.51 ( 0•30- 0.88) 0.49 ( 0.27- 0.89) 0.57 ( 0.35- 0.95) 0.48 ( 0.27- 0.84) 18<S1AV 35 62 1.34 (- 0.83- 2.17) 1.29 ( 0.78- 2.13) 1.37 f 0.76- 2.46) I 1.37 ( 0.85- 2.22) 1.15 ( 0.65• 2.01) Excludad/Trvnd 84 193 0.97 0.95 s 0.98 €€€ 0.97 0.95 POPULATION BASED STUDIES Non exposed 0<SSAV<10 10<S1AV<18 18<S1AV Exc1 uded/Trend 186 577 1,00 7•00 ( 1.00 1.00 1.00 128 267 1.05 1 0.77• 1.43) 1.06 ( 0.77- 1.46) 1.05 ( 0.72- 1.53) 1•08 ( 0.79- 1.47) 1.13 ( 0.80- 1.61) 14 48 0.50 ( 0.26- 0.97) 0.53 ( 0.28- 1.03) 0.50 ( 0.23- 1.06) 0•52 ( 0.27• 1.00) 0.55 ( 0.27- 1.12) 16 27 1.24 ( 0.62- 2.48) 1.29 ( 0.64- 2.58) 1.24 ( 0.56- 2.77) 1.26 ( 0.63- 2.53) 1.15 ( 0.51- 2•61) 34 1 31 0.64 0.60 0.61 ( 0-82 0.64 HOSPITAL BASED STUDIES ~ Non exposaG 0<S1AV<10 10<S1AV<1B 16<S1AV WITHOUT OCCASIONAL SMOKERS Non exposetl 221 558 0<S1AV<10 158 308 10<S1AV<r18 16 62 18<S1Av 2 s 42 E-xc1 uded/Trand AGE <55 YEARS f 67 134 1.00 1.00 1.00 1•00 1•00 1.19 ( 0.79- 1.78) 1.11 ( 0.69- 1.78) 1 0.98 ( 0.55• 1.74) 1.20 ( 0.80- 1.81) 0.94 ( 0.58- 1.52) 0.69 ( 0.33- 1.46) 0.52 ( 0.21• 1.28) 0.51 ( 0•19• 1.37) 0.69 ( ~ 0.33- 1.48) 0.40 ( 0.17- 0.99) 1.53 ( 0.79• 2.96) 1.32 ( 1 0.64- 2.71) 1.58 ( 0.66- 3.77) 1.56 ( 40.80- 3.02) 1.16 ( 0.54- 2.50) 0.49 1 0.52 ( 0.52 0.49 0.48 1.00 )-1•00 -- - ~ 1.00 - - 1.00 1.00 1.09 ( 0,82• 1.45)i 1.07 ( 0.79- 1.46) 0.91 ( 0.64• 1.28) 1.11 ( 0.83- 1.48) 1.00 { 0.72- 1.39) 0.49 ( 0.27- 0.89)II[i 0.39 ( 0•20- 0.78) 0•40 ( 0•20- 0.81) 0.49 ( 0.27• 0.90) 0.35 ( 0.17- 0.72) 1.29 ( 0.74- 2•24){ 1.21 ( 0.68- 2.17) 1.17 ( 0.60- 2.27) 1.32 ( 0.76- 2.29) 1.05 ( 0.55- 2.00) 0.83 tl 0.82 0.79 0.81 0.82 94 Non exposad 213 1.00 t.oo t.oa 1. 00 1•00 0<S1AV<. 10 49 93 1.08 ( 0.67- 1.73) 1.12 ( 0.67- 1.88) 1.18 ( 0.64- 2.17) 1.05 ( 0.65• 1.71) 1.16 ( 0.67- 1.98) 10<$1AV<.18 5 24 0.39 ( 0.14• 1.12) 0.38 ( 0.12- 1.21) 0.36 ( 0.09- 1.40) 0•41 ( 0.15- 1.18) 0.43 ( 0.13- 1.38) 18<S1AV B 16 0.97 1 0.37- 2•50) 0.78 ( 0.27- 2.26) 0.84 ( ~ 0.22- 3.14) 0.99 ( 0.38- 2.57) 0.83 ( 0.26- 2.65) Excludtd/Trend 9~ ~ 15 0.43 0.40 0.39 1 0•41 0.43 AGE 55-64 YEARS Non axposaa 95 289 1.OO 1.00 1.00 1.00 1.00 ( O<S1AV<10 66~ 139 1.09 ( 0.70- 1.72) 0.98 ( 0.61- 1.58) 0.72 ( 0.41- 1.24) 1.13 ( 0.72- 1.78) 0.92 .5) ( 0.54- 1 8 10<S1AV<.18 ~ 10~ 26 0.84 ( 0.36- 1.96) 0.58 ( 0.22- 1.50) 0,56 ( 0.21- 1.50) 0.85 ( 0.36- 1.98) 0.62 ( 0.23- 1.63) 18<S1AV fff ~1 15 1.95 ( 0.80- 4.79) 1.75 ( 0.69- 4.47) 1.70 ( 0.50- 5.83) 1.95 ( 0.79- 4.78) 1.62 ( 0.57- 4.59) Exeludad/Trandl 281 83 0.30 ~ 0•30 0.31 ~ 0.31 0.29 AGE 65+ YEARS Non •xpo:ed 76' 0<S1AV<10 ~ 91 10<S1AV<.18 101 18<S1AV ~ 16fI Excluded/Trend 501 HISTOLOGICALLY CONFIRMED DIAGNOSIS 276 1.00 1.00 1.00 1.00 1.00 1791 1.12 ( 0.76- 1.64) 1.16 ( 0.77- 1.75) 1.19 ( 0.72- 1.96) 1.16 ( 0.79- 1.71) 1.16 ( 0.75- 1.78) 33 0.54 t 0.24- 1.17) 0.58 ( 0.26• 1.29 ) 0.52 ( 0.20- 1.35) 0.54 (, 0.25- 1.20) 0.47 ( 0.20- 1.09) 24 1.47 ( , 0.71• 3.04) 1.60 ( 0.76- 3.37) 1.78 ( 0.78- 4-06)~ 1.51 ( 0.73- 3.13)1 1.18 ( 0.52- 2:68)~ `;17 0.82 0.82 0.74 0.81 € 0.79 ~ Non axposatl 289 778 1 00 • 1 .Oo 1.00 ( 1.0o 1.00 0<S1AV<.t0 199 dit 1 .07 1 0.83- 1.37) 1.07 ( 0.82- 1.39) 1.04 ( 0.76- 1.41)( 1.10 ( 2 85- f.41) 1.08 ( 0.81- 1.43) 90<SIAV<.10 25 S3 0.57 ( , 0.35• 0.93) 0.52 ( 0.31- 0.89) 0.50 ( 0.28• 0.91) 0.58 ( 0.35- 0.95) 0.50 ( 0.29- 0.87) 18<S1AV 331 55 1.30 ( 0.80- 2.11) 1.26 ( 0.76- 2.09) 1.38 ( 2,47)~ 0.78- 1.33 ( 0.82- 2.16) f 1.18 ( 0.68- 2.05) .xcludto/Trand! 8111 215~ 0.94 0.93 0.92 0.93 I 0.95 Non axposetl 4 9 '78 1.00 1.00 1.00 1.00 1.Oo O<S1AV<e10 ~ 32 411 1.00 ( 0.59- 1.69) 0.83 ( 0.47- 1.49)~ 0.76 { 0.39• 1.45)1 0.98 ( 0.57• 1.66) 0.82 ( 0.45- 1.51) 10<$tAV<18 5 63 0.72 ( 0.26• 1.96) 0.43 ( 0.13• f.50)f 0.51 ( 0.14• 1.85)1 0.71 ( 0.26- 1.95) 0.28 ( 0.06- 1.23) 18<S1AV ~ 5 55 1.29 ( 0.47- 3.59) 0.98 ( f 0.32- 3.00) 1.02 ( 0.28- 3.75) 1.28 ( 0,46- 3.55) 0.55 ( 0.12- 2.47) Excluded/Trrndl 18~ 215~ 0.93 ~ 0.93 lll 1 0.87 0.93 0.92 SMALL CELL CARCINOMA Non expoSeO 22 778 1,00 1.00 1•00 1.00 i 1.00 0<S1AV<10 I 27 411 1.76 ( 0.93• 3.31) 1.70 ( 0.88- 3.31) 1.85 ( 0.90- 3.82)I 1.82 ( 0.96- 3.45)~ 1.69 ( 0.87- 3.27) 10<S1AV<.18 1 83 0,27 ( 0.03• 2.11) 0.29 ( 0.04- 2.27) 0.33 ( 0.04• 2.66) 0.28 ( 0,04- 2.16) 0.27 ( 0.03- 2•14) I 18<S1AV I 2 55 0,72 ( 0.15- 3.36) 0.70 ( 0.15- 3.32) 1.00 ( 0.20- 4.97) 0.71 ( ~ 0.15- 3.35) 0.74 ( 0.15- 3.58) €xcludad/Tnnd 12 l 215 0.40 ' 1 0.39 ; 0.39 ~ f 0.40 0.40 ADENOCARCSNOMA Non aXposod 0<S1AVt10 10<$tAV<.1® 98<S1AV ExCludtd/Tnnd! OTHER 159 778 1.00 1.00 ' 1.00 1.00 1.00 107 411 0.99 ( 0.73- 1.35) 1.01 ( 0.72- 1.41) 0.97 ( 0.66• 1.43) 1.03 ( 0.75- 1.41) 1.02 ( 0.72- 1.44) 13 83 0•50 ( 0.26• 0.94) 0.46 ( 0.23• 0.92) 0.40 ( 0.18- 0.89) 0.52 ( 0.27- 0.98) 0.45 (, 0•23- 0.91) 21 55 1.40 ( 0.79- Z 46) 1.38 ( 0.76- 2.50) 1•65 ( 0.84- 3.24) 1.45 1 0.82- 2.56) 1.27 ( 0.67- 2.44) 33 215 0.9B ~ 0.97 0.99 0.98 0.99 Non axposao 53 778 1.00 1.00 1.00 1.00 1.00 0<S1AV<10 ~ 33 411 1.01 ( 0.61• 1.67) 1.12 ( 0.65- 1.93) 1•01 ( 0.54- 1.92) 1.05 ( 0.63- 1.76) 1.15 ( 0.64- 2.07)1 10<S1AV<18 6 83 0.75 ( 0.30- 1.87) 0.86 (, 0.34- 2.20) 0.84 ( 0.30- 2.37) 0.77 ( 0.31• 1.94) 0.91 ( 0.35- 2.38) 18<S1AV 5 55 1.13 ( 0.42- 3.10) 1.22 ( 0.44- 3.41) 0.89 ( 0.25- 3.20) 1.17 ( 0-43- 3.19) 1.57 ( 0.55- 4.46) Excluded/Trandj 18 215~ 0.91 0.87 0.87 0.92 0.91 >76% OF LIFESPAN IN RURAL AREA OR INTER MED IATE CITIE S Non exposed 115 270 1.00 1•00 1.00 1.00 1.00 0<S1AV<10 75 129 1•07 ( 0•70• 1.63) 1.07 !, 0.70- 1.63) 0.79 ( 0.47- 1.32) 1.07 ( 0.69- 1.64) 0.95 ( 0.61- 1.49) 10<S1AV<18 10 27 0.59 ( 0.26• 1.36) 0.59 ( 0•26- 1.36) 0.54 ( 0.22- 1.35) 0.60 ( 0.26- 1.38) 0.52 ( 0.22• 1.21) 18<S1AV i 15 18 1.70 ( 0.77- 3.74) 1.70 ( 0.77- 3.74) 1.89 ( 0•68- 5.27) 1.76 ( 0.80- 3.89) 1.32 1 0.55- 3.17)/ Excl uded/Trtr.d i 41 131 0. 54 0.54 0,49 0.55 0. 5 3 Ei >759G OF LIFESPAN IN URBAN AREA Non oxposad 103 351 1•Ob 1•00 1 1.00 1•Do 1•00 0<S1AV<10 89 220 1•05 ( 0•71- 1.53) 1.05 !, 0.71- 1.53) 1.16 ( 0.74- 1.81) 1.05 ( 0.71- 1.55) 1.14 ( 0.73- 1,78) 10<S1AV<18 8 42 0.45 ( 0.20• 1.03) 0•45 ( 0.20• 1.03) 0.42 ( ~ 0.16- i.08) 0.44 ( 0.19- 1.01) 0.49 ( 0.20- 1•22) 18<S1AV ~ 15 31 1.34 ( 0.66• 2.73) 1.34 ( 0.66- 2.73) 1.42 ( 0.63- 3.19) 1.32 { 0.65- 2.69) 1.42 ( 0.62- 3.23) Excludtd/Trand 29 67 0.93 0.93 0.93 € 0.87 0.93 (1) Model include sox, center, sex'cen!er and age (2) Model indude sax, center, sex'can!er, age and proportion of residential type in the !ast 35 yrs (REUP) (3) Modsl Include set, Center, sox'cen!er, age, proportion of residential type in the last 35 yrs (REUP) and educational level (EDUC) (4) Model Include sex, center, sex'center, age and duration of exposure to list A agents (OCLAY) (6) htotlo, tnauoo scx, center, sex•center, age and frequency consumption of vegetab es (VEGE) sxcluded/Trtndl 27 9-061-1593375 Risk estimates - Spouse 4 A C

SIDH Spouse, Duration (hours/day x years) MEN ONLY Tolal Exoosed Unexoosed Exduded Min P10 I 01 £ Median 03 P90 Max Mean ~ Std MOn C3sC5 154 21 132 1 1.60 3.43 38.50 12.00 66.00 102.54 190.57 -49.78 -49.5~ Controls 566 55 499 12 1.30 5.00 _ 12.54 30.86 86.79 167.99~ 230.57~ 55.84 61.4: ] All 737 76 _ 631 30 1.30 4.00 12.27 31.43 74.59 145.71I 230.57~ 54.16 58.1: Wam@n Cas©s o 0 0 0 Controls 0 0 0 0 tE A}l 0 0 0 0 ~ Aq CBsM 157 21 132 4 1,60 3.43 12.00! 38.50 66.00 902.54 49.5t 90.57 ---49 .78 --- 1 Controls 5801 65 499 26 1.30 5.00 12.54 30.861 86.79 167.99~ 230.57 55.84 61.4s All 737 78 631 30 1.30 4.00 12.27 31.43 74.59 745.71 230.57 54.16 58.1: WOMEN ONLY Ma1 CAs@s 0 0 0 0 1 359339~ - Controls 0 0 0 0 Atl 0 0 0 0 Womcn Csz@z 527 242 209 76 0.10 11.00 27.96 90.00 170.00~ 283.a3~7216.00 124.12! 133.1 Controls 950 494 371 85 0.05 9.29 31.43 71.34 140.00 233.14 630.00 101.72 900.6 All 1626 736 580 310 0.05 10.29 29.86 78.96 151.86 252.29 1216.00 109.08 112.7 Ap C91@f 550 242 209 99 0.10 11.00 27.96 90.00 170.00 283.43! 1216.00 124.12 --- 133.7 Controls 1076 494 1 371 211 0.05 ~ 9.29 31.43 71.34 940.00~ 233.14' 630.00 101.72 100.6 All 1fi26 736 b80 310 0.05 1 10.29 29.86 1 78.96 151.861 252.29 1216.00 109.08 __ 112.7 E 1 r E 1 % MCn Cis@s Controls All 91 444 535 15 53 68 75 383 458 1 0 9 3.03.43 20001 .5.25 2,00 4.00 10.85 38.50~ 14.00 30.86 12.70 31.43 66.00 86.79 74.59 102.54 167.99 167.99 190.57~ 230.57 230.57 46.78 57.73 55.32 50.17 61.75 59.24 WOmOn CiSCS 287 131 111 45 0.10 11.00 27.96~ 84.74 144.86 258.00 _ 1216.00 __ 115.10 _ 140.3~ Controls 506 203 194 29 0.15 9.29 30.001 66.00 119.71 194.29 561.75~ 89.72 85.75 A1l 793 414 305 74 0.10 10.00 28.93 69.29 130.18 219.43 1216.00 97.75 106.5E All CisCs Contrd3 ~ All 378 950 1328 146 336 482 186 577 763 46 37 83 0.10 8.70 0.15 8.36 0.10 8.70 23.14 69.29 25.71 59.86 25.00 62.07 137.14 112.41 127.38 232.00 188.04 207.00~ 1216.00 561.75 1216.00 108.08) 84.67 91.76 135.4C 83.1E 102.25 HOSPITAL @ASED STUDIES M@n Ci5@f 47 6 41 0 1.601 1.60 17.29 47.00 90.00 140.86 140.86 57.29 51.8C Conlrols 73 2 68 3 1.30 1.30 ~ 1.30 5.65 10.00 10.00 10.00 5.65 6.1~ All 120 8 109 3 1.30 1.30 5.80 24.64 76.00 140.86 140.86 44.38 49.9 ~ Woman Cascs ! 199 96 70 31 2.00 11.00 33.43i 112.50 227.14 308.00 525.43 145.60 126.75 Conuols ' 370 192 133 54 0.20 11.61 32.50 90.29 174.29 265.00 630.00 120.07 117.3' Al1 578 290 203 85 0.20 33.00 95.50 194.86 280.29 630.00~ 128.69 120.95 A11 sas ( 246 104 111 31 1.60 11.00 31.00 109.00 215.50 308.00 525.43 140.50 125.25 Controls 452 194 201 57 0.20 10.00 32.00 87.43 173.57I 265.00 630.00 118.89 117.25 All 696 298 312 881 0.20 10.00 32.00 93.141 189.29 277.14 630.00 126.431 120.37 1h'ITHOl1T OCCASIONAL SMOKERS Men Cif@S 110 15 94 1 1.60 3.00 10.85 41.25 56.00 102.54 140.86 46.88 41.1E Controlf 397 37 351 9 1.30 5.25 14.00 38.86 1 132.86 185.14 230.57 1 68.89 68.9E All 518 52 445 21 1.30 4.00 13.27 38.93 97.551 167.99 230.57 62.54 62.64 Women Ns@3 419 184 170 65 0.75 14.00 29.32 92.50 175.66 303.43 525.43 127.28 119.3t COntrols 747 373 297 77 0.05 10.29! 33.43 78.86 150.00 241.07 630.00 106.85 103.5E All 1240 557 467 216 0,05 11.57 32.00 83.04 157.21 265,14 630.00 113.60 109.3E All GSCS 542 199 264 79 0.75 11.57 28.36 90.001 169.71 300,43 525.43 121.22 117.22 Controls 1216 410 648 158 0.05 9.14 30.00 75.79 149.14 236.00 630.00 103.42 101.4E Afl 1758 609 912 237 0.05 10.00 28.93 79.86 151.71 257.14 630.00 109.24 107.1C AGE t55 YEARS MCn CasOf 56 8 47 1 10.85 10.85 14.53 29.27 84.27 140.86 140.86 51.00 1 48.45 Controls 170 23 143( . 4 1.30 6.96 12.54 20.00 60.75 92.57 167.99 40.99 41.65 All 229 31 190I 8 1.30 10.00 12.54 20.00 66.00 102.54 167.99 43.581 42.9; Womr@n CiSC3 138 55 09 14 1.50 11.00 21.00 33.00 99.68 123.43 475.71 70.41 87.2: Controls All 254 392 119t 119 174 188 16 0.05 30 0.051 8.00 9.00 26.43 22.18 59.14 108.00 52.21I 105.43 172.86 164.57 480.00 480.00 80.73 77.47 77.3t 80.5 AlI ClSCf 195 63 116 16 1.50 ':1.00 17.29 33.00 99.68 i23.43 475.71 67.94 83.3 Controls 426 142 262 22 0.05 8.00 20.00 51.64 101.86 167.99 480.00 74.29 74.1: All 621 205 378 381 0.05 9.00 19.00 48.00 100.29 156.00 480.00 72.34 76.9 AGE 55->4 YEARS Men Cases 52 7 45 0 1.60 1.60 3.00 32.00 58.57 190.57 190.57 49.08 65.5-. Controls 216 15 r 198 3 3.00 4.00 5.25 30.00, 133.00 I 172.71 185.14 58.04 64.5 All 266 22 243 3 1.60 3.001 5.251 30.43 58.57~ 172.71 190.57 55.19 63.4. Women Cases 166 81 65 20 0.10 9.43 28.93 119.57 177.43 257.14 406.71 119.55 96.1 ConUOls 304 162 112 30 0.15 11.57 28.30 70.64 149.14 234.29 596.00~ 100.99 101.2 A11 535 243 1771 115 0.10 9.43 28.93 82.14 167.14 242.14 596.00 107.18 99.7' AN CisC4 220 88 110 30 0.10 5.79 28.64 100.45i 174.43 257.14 406.71 113.95 95.7 Contr0ls 575 1771 310 88 0.15 6.00~ 27.75 64.29! 133.71 230.00 596.00 . 97.35 99.2 I Ali 003 2651 420 118 0.10 6.00f 27.86 74.29I 164.00 234.29 596.00 102.86 98.2 AGE=6 Man C~ses 4® 6 40 0 3.43 3.a3 4.00 59.00 78.46 90.00 90.00 48.937.0 8 Can{rols 180 17 158 5 2.00 6.75 14.29 36.40 132.86 202.50 81 77.6 230.57 73.9 All 240 23 198 19 2.00 4.00 10.86 39.00 103.71 192.00I 230.57 67.46_ 69.4 womcn Cas@z 223 108 75 42 0.75 11.57 44.00 120.70 219.75 333.64 7216.00 755.48 165.0 Controls 392 213 140 39 0.19 10.29 34.82 84.86 153.57 254.57 630.00 113.99 109.E All 899 319 215 965~ 0.19 10.61 37.29 90.00 169.71 297.14 1216.00> 127.781 731.8 Atl Ces@f 'r284 112 115 57 0.75 10.61 43.50 104.29 215.501 333.20 1216.00 149.77 162.4 ~ CONrois All € 655 939 230 342 298 413 127 184 0.19 0.19 9.64 10.00 33.43 34.82 81.45 87.79 152.50 167.43 246.68 278.57 630.00 111.04 108.C 1216.00 123.72 129 4 ` 206 -

S1 AV Spouse, Average exposure (cigarettes/dav) HISTOLOGICALLY CONFIRMED DIAGNOSIS 7oWl Exposed I Unexposed Exduded ~ Min P10 01 Median I 03 1 P90 i Max Mean _ Std M@n C+ssCs 149 22 127 0 0.13 ?.57 3.00 1 4.511 7.00 8.37 10.31 4.82 2.76 COntr0ls 566 58 1 499 9 0.10~ 1.00 2.00 4.14 7.18~ 11.791 25.71 5 52~ 5 13 i IAp 732 801 626 26 0.10 1.00 2.04 1 1 4.35 7.09 10.161 25.711 , 5.33 . 4.59 Wonlcn Cnas 613 248 205 60 0.05 1.50 2.84 6.00 10.00 20.83 53.31 8.68 9.06 Controls 950 510 371 69 0.05 1.50 3.21 5.61 11.25 18.57 60.00 8.23 7.641 An 1607 768 676 273 0.05 1.50 3.00 5.71 10.71 19.13 60.00 8.38 8.13 A!I COsCs 683 270 332 81 0.05 1.54 2.86 5.71 10.00 20.00 53.31! 8.37 8.78 Controlf 1856 568 870 218 0.05 1.41 3.00 5.57 10.30 17.96 60.00 7.95 7.46 All 2339 838 1202 299 0.05 /.50 3.00 5.57 t0.00 18.57 60.00 8.09 7.91 SOUAMOUS CELL CARCINOMA MCn C9SC4 281 1 27 0 5.00 5.00 5.00 5.00' 5.00 ~ 5.00 5.00 5.00 0.001 ~ COntrOlf 586 58 499 9 0.10 1.00 2.00 4.14f 7.18 11.79 25.71 5.52 5.131 1 All 608 59 526 23 0.10 1.00 2.00 ~ 4.29 7.18 i1.79 25.71 5.51 5.081 WOrttCn C1sCs 91 4 35 12 1.00 1.50 3.00 6.34 10.29 18.57! 40.00 8.31 7.44 Conlrols 950 510 371 59 0.05 1.50 3.21 5.61 11.25 18.571 60.00 8.23 7.64 All ~ 1173 554 406 213 0.05 1.50 3.19 5.71 10.99 18.571 60.00 8.24 7.62 All C.1s€s 125 45 62 18 1.00 1.50 3.00 6.25 10.29 18.57 40.00 8.23 7.38 Controls 1656 668 870 218 0.05 1.41 3.00 5.571 10.30 17.96 60.001 7.95 7.46 A11 1781 613 932 236 0.05 1.50 3.00 i 5.57 10.29 7.96 "0.001 7.97 7.45 Men Cas¢s 13 2 /1 0 3.00 3.00 3.00 4.88 6.75 6.75 6.75 4.88 2.65 Controls 566 58 499 ' 9 0.10 L 00 2.00 4.14I '.18 11.79 25.71 5.52 5.13 All 524 60 510 24 0.10 ?.00 2.04 4.14i 7.09 11.61~ 25.71 5.50 5.05 WOn1@n C@9CL 62 31 25 6 0.20 1.50 2.21 4.50 7.50 10.00 36.75 6.19 7.23 COn!!df 950 510 371 69 0.05 1.50 3.21 5.611 11.25 18.57 60.00 ".231 7.64 AA 1143 541 396 206 0.05 1.50 3.10 5.57 10.711 18.11~ 60.00 8.11i 7.62 Atl CLsa 81 33 35 12 0.20 1.50 2.25 7.a7 10.001 36.75 4.50 6.11 7.02 ~ COntfCls 1656 568 870 218 0.05 1.41 3.00 1 5.57 10.30 17.96 60.00 7.95 7.46~ All 1 737 601 906 230 0.05 1.50 3.00 5.431 10.001 17.14 60.00 7.85 7.44 SMALL CELL CARCINOMA ADENOCARCINOMA Mon C95Ef 791 Cantrols 666 All i 660 14 58~ ,"•2 ®51 0 ?.47 499 9 0.10 5641 24 0.10 1.57 1.00 1.00 3.00 4.40 7.50 2.00 4.14 7.18 2.04 4.321 7.24 9.29 11.79 10.31 10.31 25.71 25.71~ 4.98 5.52 5.42 2.92 5.13 4.77 WOmCn CES@S 277 134 11528 0.10 1.86 2.57! 6.14 10.59 22.14 45.71 8.96 9.14 COntrols 950 510 3711 69~ 0.05 1.50) 5.61 11.25~ 3.21 18.57 50.00 8.23 7.64 All 1357 644 486 227 0.05 ?.50 ~ 5 3.00 ",72 11.151 I 19.13 60.00 8.38 7.971 Aq C9S@f 361 148 180 33 0.10 1.57 2.53 6.00 10.00 21.43 45.71 8.58 8.82 COtltfoif ~ 1656 568 870 218~ 0.05 1.41 3.001 5.57f 10.30 17.96 60.00 7.95 7.46 All 2017 716 1050 251 0.05 ':.50 3.00 5.57 10.05 18.57 60.00 8.08 7.76 OTHER MM CLS@f 29 5 24 0 0.13 0.13 2.00 4.82 7.00 7.50 7.50 4.29 3.181 ContrGs 566 58~ 499 9 ~ 0.10 1.00i 2.00 4.14 7.18 11.79 25.71 5.52 5.13/ All 810 63yi 523 24 0.10 1.00f 2.00 4.29 7.18 11.43 25.71 5.42 4.99 Wan@n Cases 83 391 .~ 30 14 0.05 2.33 3.57 7.50 12.86 20.00 53.31 10.15 11.35 Controls 950 510~ 371 69 0.05 1.50 3.21 5.61 11.25 18.57 60.00 8.23 7.64C AN 1162 549 4011 212 0.05 1.50 3.29 6.64 11.25 18.57 60.00 8.37 7.96 All COS@s 116 44 54 18 0.05 2.00 3.43 6.17 10.38 19.49 53.31 9.49 10.88 Controls 1856 568 1 870 ^18 0.05 1.41 3.00 5.57 10.30 17.96 60.00 7.95 7.46 Alt 1772 612 924 236 0.05 1.50 3.00 5.57 10.30 17.96 60.00 8.06 7.761 s75'A OF LIFESPAN IN RURAL AREA OR INTERMEDIATE CITIES M2n CiSCS 73 fi 67 COntt01S 212 9 200 0 2.00 2.00 3.00 4.58 6.43 8.37 8.37 4.83 2.31 3 2.25f 2.25 3.75 5.00 7.50 13.39 13.3,1 6.09 3.65 All 3011 15 ~ 267 19 2.00f 2.25 3.001 4.821 7.50 10.00 13.39 5.58 3.15 WOmCn C75@f 107 2201 92 21 0.10 1 1.07 2.25 5.25 10.00 22.86 50.00 8.75 10.03 Controls 381! 184 160 17~ 0.06 1.50 3.111 5.251 11.25 18.11 41.71 8.01 7.30 AII 699 291 2S2 158 0.06 .50 .50 1 2.80 5.251 10.59 19.05 50.00 8.28 8.40F t Atl CaSCf COnIf01f All 313 113! 193I 807 1000 306f 591 360 519 1 0.10 134 0.06 175 0.06 1.18 1.50 1.50 2.25 5.25 10.00 3.21 5.25 10.991 2.86 5.25 10.001 22.50 t7.96 18.57 50.00 41.71 50.00 8.54 7.92 8.151 9.81 7.t8 1 8.2a ~75?C OF LIFESPAN IN URBAN AREA Mon Cascs 48 12 36 0 1.47 2.00 3.00 4.51 7.25 7.50 10.31 5.08 2.70 Controls 257 36 216 5 0.201 1.00 1.64 4.39 7.58 12.861 25.71 5.99 5.89 AQ 345 48 252 5 0.20 1.00 2.04 4.48 7.40 11 .431 25.71 5.76 5.26 Women 100 t93 Cases 67 26 0.05 2.13 3.07 5.29 10.00 20.63 53.31 8.71 8.70 Controls 435( 257 135 43 0.051 1.50 3.10 5.57 10.86 18.57 60.00 8.30 8.11 ~ 357 All 6501 202 91 0.05 1.86 3.10 5.53 10.71 19.14) 60.00 8.41 8.27 All C2S3f 294. 112 103 29 0.05 2.00 3.00 5.22 9.46 20.00 53.31 8.32 8.33 ~ ConUOls 11 293 ~ 351 67 0.05 1.29 3.00 5.46 1 10.10 18.57 60.00 8.01 7.90 ~ 405 All 955 454 96 0.05 1.50 3.00 5.29 1 10.00 18.86, 60.00 8.10 8.01 -~ 2~Jb3S93400 ,--,

WOWD Workplace, Weighted duration (hours x level) ITALY 2 Total Exoosed Unexposed Excluded ~ Min P10 € 01 Median 1 03 ; P90 Max Mean Std M011 CSSOS € 3 2 1 0 17971.20 17971.20 17971.20 26041.60 34112.00 34112.00 34112.00 26041.60 11413.27 Controls ~ 60840.00 23957.65 All 100 52 43 5~ 1612.00 2984.80 ( 4550.00 11778.00 26669.00' 198016.00 34626.21 WomCn CaSC2 16 7 9 0 1560.00 1560.00 4368.00 11481.60 18283.20 120120.00 120120.00 26229.54 41834.92 Controls 76 17 58 1 832.00 1164.80 2496.00 4680.00 6364.80{t 52416.00 91728.00 12944.64 23736.52 AII 92 24 67 1 832.00 1560.00 2496.00 5226.00 14521.001 52416.00 120120.00 16819.40 29775.11 AH CesCS 19 9 10 0 1560.00 1560.00 11232.00 16562.00 18283.20 120120.00 120120.00 26187.78 36454.22 Controls 173 67 100 6 832.00 2059.20 3744.00 9152.00~ 22152.00 59280.00 198016.00 21163.30 32928.42 All 192 76 110 61 832.00 2059.20 3822.00 10592.40 21996.00 59280.00 198016.00 21758.31 33144.96 STALY 3 Men Csscs 1 0 0 Controls 12 3 8 1 8736.00 8736.00 8736.00 18720.00 119808.00~ 119808.00 119808.00 49088.00 ~ 61448.42 AN 13 3 9 8736.00 8736.00 8736.00 18720.00 ~ 119808.001 119808.00 119808.00 49088.00 ~ 61448.42 Wp11Sfl C9stS 15 1 14 0 56160.00 56160.00 56160.001 56160.00 56160.00 56160.00 56160.00 56160.00 0.00 Controls 38 8 27 3 1414.40 1414.40 15548.00 29744.00 66300.00 179712.00 179712.00 50538.80 57933.82 A(I 53 9 41 3 1414.40 1414.40 19656.00 32448.00 56160.00 179712.00 179712.00 51163.38 54224.51 AG COSC9 16 1 15 0 56160.00 56160.00 56160.00 56160.00 56160.00 56160.001 56160.00 56160.00 0.00 COntrG15 50 11 35 4 1414.40 8736.00 11440.00 27040.00 82680.00 119808.00 179712.00 50143.13 55723.16 A11 66 12 50 4 1414.40 8736.00 15080.00 29744.00 69420.001 119808.00i 179712.00 50644.53 53158.33 PORTUGALI Mott CeseS 16 11 3 2 1216.80 1924.00 4680.00 17160.00 41600.00 42432.00 67392.00 21453.31~ 20673.77 COtltfol8 8 3 3 2 14560.00 14560.00 14560.00 ~ 20800.00 47840.00 47840.00 47840.00 ~ 27733.331 97690.79 All 24 14 6 4 1216.80 1924.00 10764.00 17752.80 41600.00 47840.00 67392.00 22799.03~ 19597.62 Won1Cn CaseS 33 15 16 2 124.80 1320.80 4940.00 13260.00 53664.00 68640.00 94796.00 25146.51 30268.30 Controls 31 9 21 1 6240.00 6240.00 8736.00 12480.00 14976.00 20020.00 20020.00 12734.22 4969.91 All 64 24 37 3 124.80 3744.00 5642.00 12870.00 19760.00 66560.001 94796.00 20491.90~ 24575.17 lAII C856t ; 49 26 19 4 124.80 1320.80 4940.00 13455.00 41600.00 67392.00 94796.00 23584.00 26219,811 COnl70lS 39 12 24 3 6240.00 8580.00 8918.00 14768.00 19760.00~ 20800.00 47840.00 16484.00 10994.53! All 88 38 43 124.80 1924.00 5824.00 14105.00 20800.00 66560.00 94796.00 21341.89 22619.37 PORTUGAL 2 MQtt CAsCS 10 2 7 1 23660.00 23660.00 23660.00 57499.00 91338.00 91338.00 91338.00 57499.00 47855.57 Controls 17 7 10 0 520.00 520.00 1123.20 12012.00 32760.00 35880.00 35880.00 15919.43 15379.811 Ad 27 9 17 1 520.00 520.00 3120.00 23660.00 32760.00 91338.00 91338.00 25159.33 28281 4E WOR1Cn C85ei $3 6 16 1 748.80 748.80 2808.00 4446.00 4680.00 8320.00 8320.00 4241.47 2497.04 Controls 36 7 29 0 1300.00 1300.00 2329.60 11606.40 18720.00 22713.60 22713.60 11494.23 7911.?2 A!I 59 13 45 748.80 1300.00 2808.00 4680.001 11606.40 j 18720.00 22713.60 8146.80 6932.16 '.411 CaseS 33 8 23 2 748.80 748.80 3588.00 4602.00 15990.00 91338.00 91338.00 17555.85 30649 82 Controls 53 14 39 0 520.00 1123.20 2329.60 11809.20 22713.60 32760.00 35880.00 13706.83 11972 10 All 86 22 62 2 520.00 1123.20 2808.00 9035.00 22713.60 32760.00 91338.00 15106.47 20135 9' SPAIN MCn C95eS 6 5 0 1 4368.00 4368.00 5824.00 34944.001 59280.00~ 70720.00 70720.00 35027.20 30228.28 Controls 13 9 3 1 2496.00Ip 2496.00 17305.60 25001.60 34320.00 182000.00 I 182000.00 45891.73 ~ 57241.2' All 19 14 3 2 2496.001 4368.00 11648.00 25240.80 59280.00 93184.00 182000.00 42011.54 48235 73 WOroCn C2:eS 65 29 32 4 124.80 520.00 4492.80 8985.60 25958.40 56056.00 142355.20 20629.30 29398 Controls 146 59 81 6 41.60 1092.00 3900.00 8190.00 18886.40 36400.00 76294.40 13925.07 15676.43 AH 211 88 113 10 41.60 873.60~ 3900.00 8528.00~ 20883.20 39603.20 142355.20~ 16134.42 21260 97~ A8 C35e3 71 34 32 5 124.80 520.00 4492.80 9224.80' 29952.00 59280.00 142355.20 22746.64 2951L.L Contr011 159 68 64 7 41.60 1497.60 3900.00 11065.60 21278.4037876.80 182000.00 18155.95 26889.94 Ad 230 102 f16~ 12 41.60 ~ 1092.00 3993.60 9973.60 25480.00 46550.40 182000.00 19686.18 27729.50 SWEDEN MCn CaSCt 23 21 2 0 286.00 769.60 2402.40 4264.00 7488.00 35100.00 61568.00 10082.55 15413.94 C~1lfo1S 36 321 4 0 10.40 572.00 1014.00 2080.00 7098.00 9599.20 20841.60 4386.53 4751.13 AH 59 531 6 0 10.401 572.00 1404.00 3192.80 7488.00 12396.80 61568.00 6643.44 10618.32 WOmCn C95CS 47 41 6 0 31.20 260.00 1326.00 2210.001 14560.00 38454.00 53128.00 10658.81 15227.00 COn17019 76 59 17 0 20.80 187.20 587.60 2184.00. 6656.00 19344.00 42588.00 5672.14 8554.67 All 123 100 23 0 20.80 228.80 624.00 2207.40 8829.60~ 22776.00 63128.00 7716.68 11942.87 AH Cases 70 62 8 0 31.20 384.80 1383.20 3686.80 13000.00 35796.80 63128.00 10463.62 15166.22 Controls 112 91 21 0 10.40 249.60 759.20 2080.00 6656.00 12396.80 42588.00 5220.06 7437.62 _ ~ All 182 153 29 0 10.40 286.001 884.00 2402.40 7956.00 20592.00 63128.001 7344.90 11477.50 UNITEO KINGDOM MCn C7SM 3 3 0 0 21840.00 21840.00 21840.00 28080.00 31200.00 31200.00 31200.00 4765.88 27040.00 Controls 14 13 i 0 520.00~ 1300.00 2730.00 6110.00 16640.00 43290.00 54080.00 ~ 14690.00 16998.79 AN 17 16 1 0 520.00 1300.00 2990.00 14235.00 27235.00 43290.00 54080.00 17005.63 16092.87 WOmCn Cases 23 10 13 0 520.00 1040.00 2080.00 7345.00 13520.00 20540.00 21710.00 8892.00 7606.75 j Controls 126 8s~ 61 0 260.00 520.00 1170.00 4160.00 12480.00 21060.00 36400.00 7950.00 8885.24 AH 149. 75~ 74 0 260.00~ 520.00 1170.00 4680.001 13520.00 21060.00 36400.00~ 8075.60 8684.48 A11 CaseS 26 13 13 0II 520.00 1560.001 2860.00 12610.00 21710.00 28080.00 31200.00 13080.00 10512.80 Controls 140 78 62 260.00 0 520.001 1300.00 4940.00 14560.00 25220.00 54080.00 9073.33i 10818.62 Afl 166 91 75 1 0 260.00 520.00 1430.00 5460.00 14560.00 25220.00 54080.00 9645.71i 10810.171 2063593402

C_S1 CS Spouse, Cumulative exposure of smoking spouse (packs/day x years) MEN ONLY tava) ot nxoosurn Casas Conhots { OR 1 95%CI OR(2) 95% Cs ( OR(3) 95% Cl ( C1R(4 95% Cf O R 5) 95% Cl Non exposad 81 378 1.00 1.00 1.00 1.00 1 1.00 O<S1CS<•35 18 55 1.74 ( 0.87- 3.46) 1.93 ( 0.92- 4.06) 1,37 ( 0.45- 4.20) 1.71 ( 0.86- 3.43)1 2.01 ( 0.90• 4.51) ~ 35<S1C3<53 0 4 0.00 ( 0,00•99.99) 0.00 ( 0.00-99.99) 0.00 ( 0,00•99.99) 0.00 ( 0.00-99.99) 0.00 ( 0.00-99.99 II) £xcludld/Trand 42 941 0.40 0.42 0.38 I 0.40 ~ 0.39 ~ WOMEN ONLY Non exposcd 0<S1CS<35 35<S1CS<b2 52<S1CS €XCluddd/Trend ! 127 267 t.oo 1.00 1.00 1.00 1.00 124 317 0.91 ( 0.67- 1.23) 0.92 ( 0.66- 1.29) 0.94 ( 0.62- 1.41) 0.93 ( 0.68- 1.27) 0.87 (, 0.60- 1.26) 34 72 1.09 ( 0.67- 1.75) 1.06 ( 0.64- 1.77) 0.94 ( 0.52• 1.73) 1.17 ( 0.72- t.89) 1.02 ( 0.58- 1.78) 30 61 1.30 ( 0.78- 2,18) 1.09 ( 0•61- 1.94) 1.15 ( 0.59- 2.24) 1.36 ( 0.81- 2.28) 0.84 ( 0.43- 1.62) 194 304 0.28 0.25 0.28 0.28 0.31 POflUtAT10N BASED STUDIES Non axposad 0<S1C3<35 35<$ CS<•52 1 52<S1C$ EXSludsd/Trend HOSPRAL BASED STUDIES sa 44a 1.00 1.00 1.00 1 1.00 1.00 67 225 0.91 ( 0.61- 1.34) 0.97 ( 0.64- 1.45) 1.02 ( 0.59- 1.76) 0.94 ( 0.63• 1141) 7.12 { 0.69- 1.83) 12 24 i 1.51 ( 0.70- 3.28) 1.66 ( 0.74- 3.76) 1.78 ( 0.69- 4.59) 1.66 ( 0.76- 3.64) 2.80 ( 0.97- 8.08) 9 27 0.86 ( 0.38- 1.98) 0.98 ( 0.42- 2.26) 0.83 ( 0.30- 2.30) 0.91 { 0.40- 2.11) 0.51 ( 0.15- 1.69) 192 230 0.82 0.86 0.90 0.84 t 0.83 Non ®xposa 110 201 1-00 1.00 1,00 1•00 1-00 0<S1CS<35 75 147 1.10 ( 0.74- 1.65) 1.08 ( 0.67- 1.73) 0.96 ( 0.54- i,71) 1.10 ( 0.73• 1.65) 0.90 ( 0.56- 1.45) 35<S1CS<a52 22 52 1.04 ( 0.57- 1.88) 0.93 ( 0.49- 1.78) 0,81 ( 0.37- 1•75) 1.10 ( 0.60- 1.99) 0.80 ( 0.41- 1.56) 62<S1CS ( 21 24 1.93 ( 0.99- 3.78) 1.36 ( 0.61- 3.00) 1.82 ( 0.72- 4.56) 1.97 ( 1.00- 3.86) 1.19 ( 0.53- 2.66) €XCludad/Trend( 18~ 28 0.13 0.13 1 0.09 0.13 0.14 WiTHOUT OCCSIONAL SMOKERS A Non ®%posetl 133 0<S1CS<.35 103 35<S1CS<b2 E 22 52<S1CS +`{ 21 Excludsd/Trand 207 437 1.00 7.00 1.00 € 1.00 1.00 257 1.11 ( 0.80- 1.56) 1.14 f, 0.78- 1.67) 0.94 ( 0.60- 1,47)~ 1.13 ( 0.80- 1.60) 1.05 ( 0.68- 1.61)1 61 0.91 ( 0.51- 1.59) 0.92 ( 0.50- 1.69) 0.77 ( 0.38• 1.57)I 0.98 ( 0.56- 1.74) 0.73 ( 0.36- 1.46) 41 1.26 ( 0.69- 2.29) 0.91 ( 0.46- 9.82j 0.86 ( 0.40- 1.86)f 1.32 ( 0.72- 2.41) 0.69 ( ~ 0.31- 1.51) 308 0.63 0.62 ~ 0.66 ii{ 0.63 0.68 AGE <55 YEARS Non expoa.a 0<81CS<35 35<S1CS<.52 52<SICS Fxcluded/Tro nd AGE 55•G4 YEARS 68 178 1.00 1.00 1.00 1 0 0 O ' 1.00 44 107 0.90 ( 0.54• 1.50) 0.97 ( 0.55• 1.73) 1.06 ( 0.51- 2.21)1 0.88 ( 0.52- 1.49) 0.96 ( 0.53- 1.76) 3 13 0.45 ( 0.12- 5,75) 0.61 ( , 0.15- 2.50) 0.51 ( 0.09- 2.80)1 0.48 ( 0.12- 1.87) 0.39 ( 0.08- 2.02) 3 6 1.32 ( 0.27- 6.50) 0.00 ( 0.00-99.99} 0.00 ( 0.00-99.99) 1.35 ( 0.27- 6.76) 3.82 ( 0.16•93,8a)~ 48 57 0.59 0.60 0.56 E 0.55 0.58 Non .xpos.d St 229 1.00 1•00 1.00 1.00 1 .00 0<S1CS<.35 41 127 1•14 (, 0,66- 1.98) 1•00 ( 0.55- 1.81) 0.66 ( 0.31- 1.37) 1•20 ( 0.69- 2•10) 1.12 ( 0.55- 2•29) 35eS1CS<r$2 13 19 2.73 ( 1•16• 6,45) 2,23 ( 0.89- 5.58) 1.74 1 0.61- 5•01) 2•79 ( 1.17- 6•62)~ 2.12 ( 0.77- 5•87) 52<S1CS 12 13~ 2.93 ( 1.16- 7•43) 2.21 ( 0.79- 6.14) 2.49 ( 0•72- 8.57) 2•97 ( 1.17- 7•55) 2.04 ( 0.64- 6.52) c'xcluded/Trand~ 93 164~ 0.00 E 0.00 0.00 0.00 ( 0.00 E AGE 65+ YEARS 0%posatl 88 0<S1CS<e35 57 CS<.52 18 35<S1 Non Exclud.dl 52<S1CS , 15 Tr.ndj 97~ HISTOLOGICALLY CONFIRMED DIAGNOSIS Non axposed 200 0<$1CS<35 136 35<S1CS<.52 °u2 <S 1C6 33 <S1C6 27 Fxcludrd/TrendJ e31! SOUAMOUS CELL CARCINOMA t+on exposed 2a 0<S10S<a35 22 35<S1CS<62 6 s2<stcs 4 Fxcluded/Trend 49 238 1.00 - 1.00 1.00 1.00 7.00 138 0.95 ( 0.61- 1.48) 1.03 ( 0.64• 1.66) 1.13 ( 0.61- 2.08) 0.97 ( 0.62- 1.51) 0.96 ( 0.57- 1.621 44 0.94 ( 0.49• 1.81) 0,96 ( 0.48- 1.93) 0.95 ( 0.41- 2.23) 1.04 ( 0.54- 2,02) 1.00 ( 0.48- 2.tt1 32 1.02 ( 0.50- 2.07) 1.06 ( 0-51- 2.22) 1.12 ( 0.47- 2.66) 1.08 ( 0.53- 2.19) 0.60 { 0.25- 7.421 177 1.00 0.99 0.93 0.99 0.95 645 ~ 1.0o t.0o 1.00 1.0o t.oo 372 0.96 ( 0.73- 1.28) 1.00 ( 0.73- 1.36) 0.99 ( 0.68- 1.46) 0.99 1 0.75- 1.33) 1.00 ( 0.72- 1.a17 7fi 1.11 ( 0,69• 1.78 1 1.10 ( 0.67• 1.83) 0.99 ( 0•55• 1•79) 1.19 ( 0•7a- 1.92) 1.10 ( 0.63- t.90i ~ 51 1.24 t, 0.73- 2.10) 1.05 ( 0.59- 1.89) 1.22 { 0.63- 2.36) 1.30 ( 0.76- 2.20) 0.92 { O.aB• 7.78i 398 0.35 0.35 0.37 ~ 0.36 0•38 645 1.00 1.00 1.00 1.00 1.00 372 1.18 ( 0.61- 2.26) 1.00 ( 0.48- 2.09) 1.30 ( 0.52- 3.25) 1.13 ( 0.59- 2.19) 1.01 0.45- 2.28i ( 76 1.46 ( 0.53- 4.01) 0.72 ( 0.19- 2,68) 0.31 ( 0.04- 2.60)1 1.48 ( 0.53- 4.08) 0.80 0.21- 's.o8) ( 51, 1.44 f, 0.45- 4.66) 1.02 ( 0.27- 3.83) 1.44 ( 0.35• 5.92) 1.43 ( 0.44- 4.62) 0•77 ( o.1s• 3.72) 3981 0.35 0.35 0.37 ' 0.35 SMALL CELL CARCINOMA Non oxpos.d 0<S1CS<35 36<SiCSu52 ~ 52<$yCS I €xcludod/Tr`andl ADENOCARCINOMA 6a5 1.00 1.00 1.00 1.00 1.00 13 372 1.55 ( 0.65- 3.70) 1.64 (, 0.64- 4.18) 2.27 { 0.76- 6.78) 1.66 ( 0.68- 4.03) 1.62 ( 0.62• 4.21) 5 76 2.45 ( 0.76- 7.92) 2.08 ( 0.55- 7.78) 3.62 ( 0.82•15.87) 2.60 { 0.79- 8.59) 2.83 ( 0.80•10.03; 7 51 0.34 ( 0.04- 2.88) 0.37 ( 0.04- 3.20) 0.54 ( 0.06- 5.15) 0.33 ( 0.04- 2.81) 0.00 ( 0.00•99.99; 37 398 0.97 0.95 € 0.91 0.97 1.00 Non exposed 113 645 1•00 i 1•00 1.00 1-00 1.00 q<S1CS<35 ~ 74 372 0,88 ( 0.62- 1•26) 0.91 ( 0.62- 1.35) 0.89 ( 0.54- 1.47) 3 0,9 ( 0•64• 1•33) 0•92 ( ~ 0.61- 1.40) 35<S1CSa52 17 76 0.99 1 ( 0.54- 1,81) 1,11 ( 0.60- 2.08) 0.89 ( 0•41• 1•91) 1.08 ( 0,59- 1.99) 1.01 ( 0.50- 2•00) 52<SICS ~ 15 SS 1.22 ( 0.64- 2.33) 0.96 ( 0.45- 2.05) 1.06 ( 0.44- 2.54) 1.29 ( 0.67- 2.48) 0.82 ( 0.35- 1.91) tI €~.rs1 udid/Trend ?f4 398 0.61 1 0.59 0.63 1 0.61 0.64 ~ OTHER Non •xpaa.o 45 645 1.00 1,00 1.00 f. 1•00 1•00 Q<SiCS<35 27 372 1 0.90 ( 0.52- 1.56) 1,03 ( 0.57• 1.87) 0.85 ( 0.41- 1.77 1 0.54- 1.64) 1 0.94 1.08 ( 0.56- 2.07) 35<S1CS<52 5 76 0.79 (, - 2,19) 9) 0.93 1 0.33- 2.64) ' 0.96 ( 0.32- 2.86 { 0.87 0.37• 2.43) ~ 0.95 ( 0.29- 3.05) 52<S1CS ~ 51 62 . I ( 0.65- 1 1.61 ( 0.59- 4.35) 1.75 ( 0.57- 5.37)j 1.72 ( 0.68- 4.32) 2.22 ( 0.78- 6.31) ~ E.rclOded/Trend 3f~ 398~ 52 0. 0.53 0.55 EE€ 0.50 0.52 >7554 OF LIFESPAN IN RURAL AREA OR INTERMEDIATE CITIES - Non axpaaa d 41 178 1,00 1•00 1-00 1.00 , 1•00 ~ 0<S1CS<35 41 92 1.40 ( 0,80• 2•48) 1•40 ( 0•80• 2.48) 1.00 ( 0.43- 2•30) 1.39 ( 0.78- 2.49) 1,14 ( 0•61 - 2-15) 35<S1CS<r58 ~ ~ 11 21 1.45 ( 0,60- 3.52) 1.45 ( 0,60• 3,52)( 1.17 ( 0.38- 3.61) 1.55 ( 0.63- 3•78) 1•08 ( 0.41- 2.87) 52<S1CS 8 14 2.00 f, 0.72- 5.54) 2.00 ( 0.72- 5.54) f 2.71 ( 0.74- 9.86) 2.12 (- 0•76- 5.91) 1.23 ( 0.38- 4•03-)~ fxcl0dtd/Trend l ?48~ 270 0,14 0-14 ` ( 0.13 I 0•15 0.14 >75'fi OF UFESPAN IN URBAN AREA Non exposed a5 324 1.00 1.OO 1.00 1-00 1.00 0<SiCS<35 62 1 213 0.83 ( 0.55- 1.27) 0.83 ( 0.55• 1.27) 0.91 1 0.55- 1.51) 0•83 ( 0•54• 1.27) 0•98 ( 0•59- 1.62) 35<S1CS<n52 17 43 1.05 ( 0.54• 2.06) 1.05 ( 0.54- 2.06) 1.09 ( 0.51- 2 34) 1.13 ( 0.57• 2.24) 1.21 ( 0.54- 2•71) 52<S1CS 13 32 1.03 ( 0.49- 2.17) 1.03 ( 0.49- 2.17) 1.03 ( 0.44• 2.42) 1.02 ( 0.48- 2.14) 0.91 ( 0.37- 2-26)i Fxcluded/Trend 67 1 99 0.79 0.79 ~ 0.80 1 0.81 i 0•8 2 liii (1) Model Include sex, canter, scx'center and age (2) MaCCt inctuda sex, center, sex csnter, a9e and proportion of residential type in the test 35 yrs (REUP) (3) Model Include sex. cen(er, sex•center, ape, propOrtlon of residential type in the last 35 yrs (REUP) and educational level (EDUC) (4) Model Include sex, center, sex•cen)er. age and duralion el exposwe to rst A agenes (octAY) (5) MoCel Include sex, center, aex'csnter, a9e and frequency consumption of vegetables (VEGE) Risk estimates_- Spouse

Spouse, Cumulative exposure (packs/day x years) ASEN flNLY Level of exposure Cases tlon Cxpos®C 116 Q<51GU<.13 21 13<SiCU<23 1 Controls OR(1) 95x CI ~ OR(2) 95'h CI ~ OR 3) 95% CI ( OR 4) 95% CI OR(5) 95% CI 451 1.00 1.00 1.00 1.00 , 1.00 53 1.61 ( 0.85- 3.04) 1.74 ( 0.87- 3.47) 1.37 ( 0.53- 3.52) 1.60 ( 0.85- 3.04) 1.62 ( 0.79- 3.31) S 1.88 ( 0.18•19.52) 1.87 ( 0.18-19.79) 0.00 { 0.00-99.99) 1.96 ( 0.19•20.43) 4.96 ( 0.25-100.3) Excludcd/Tnnd 3 22 0.16 0.19 0.19 0.16 0.16 EYOMEN ONLY Non expOSOtl 181 327 1.00 1.00 1.00 , 1.00 1.00 0<S1CU<13 167 358 0.91 ( 0.70- 1.19) 0.92 ( 0.69- 1.22) 0.94 ( 0.68- 1.31) 0.93 { 0.71- t.22) 0.88 ( 0.65- 1.20) 73<S1CU<23 35 78 0.83 ( 0.52- 1.30) 0.72 ( 0.43- 9.19) 0.47 ( 0.25- 0.87) 0.87 ( 0.55- 1.38) 0.61 ( 0.36- 1.04) 23<S1CU 42 55 1.54 ( 0.97- 2.44) 1.44 ( 0.89• 2.34) 1.41 ( 0.82- 2.41) 1.57 ( 0.99- 2.50) 1.41 ( 0.82- 2.41) Excluded/Trend 84 193 0.15 ~ 0.14 0.14 0.14 0.16 POPULATfON BASED STUDIES Non axpossd 0<SiCU<13 13<S1CU<29 23<S1CU 186 - ! 577 1.00 1.00 1.00 1.00 1.00 121 276 0.95 ( 0.70- 1.30) 0.97 ( 0.70• 1.33) 0.99 ( 0.68- 1.44) 0.98 ( 0.71- 1.34) 1.00 ( 0.71- 1.42) 16 37 0.83 ( 0.43- 1.60) 0.80 ( 0.41- 1.57) 0.62 ( 0.28- 1.39) 0.85 ( 0.44- 1.65) 0.90 ( 0.43- 1.88) 21 29 1.45 ( 0.77- 2.74) 1.51 ( 0.79- 2.86) 1.29 ( 0.64- 2.60) 1.49 ( 0.79- 2.82) 1.58 ( 0.74- 3.34) EXC1Udfd/T/Ynd 94 31 0.41 0.44 0.43 0.41 E 0.41 HOSPITAL BASED STUDIES o%pOfotl Non 0<S7CU<13 <S1CU<2g 13 83<51CU 111 201 1.00 1.00 1.00 1.00 1.00 67 135 1.09 ( 0.72- 1.64) 1.04 ( 0.64- 1.69) 1.04 ( 0.58- 1.86) 1.08 ( 0.71- 1.64) 0.90 ( 0.55- 1.46) 20 46 0.97 ( 0.53- 1.81) 0.77 ( 0.37- 1.59) 0.39 ( 0.14- 1.04) 1.03 ( 0.56- 1.93) 0.52 ( 0.24• 1.12) 21 26 1.89 ( 0.97- 3.69) 1.54 { 0.73- 3.24) 1.91 ( 0.81- 4.46) 1.92 ( Q.98- 3.75) 1.45 ( 0.67- 3.17) Excluded/Tr.nd <7~ 44 0.12 0.12 0.10 0.11 , 0.12 1 WITNOUT OCCASIONAL SMOKERS e%poSed 221 Non 558 1.00 1.00 1.00 1.00 1.00 0<S1CU<13 140 298 1.01 ( 0.75- 1.35) 1.00 ( 0.73- 1.37) 0.87 ( 0.61- 1.23) 1.02 ( 0.76- 1.37) 0.95 ( 0.68- 1.33) 13<S1CU<23 28 67 0.84 ( 0.51- 1.40) 0.74 ( 0.42- 1.30) 0.53 ( 0.28- 1.01) 0.89 { 0.54- 1.49) 0.57 ( 0.31- 1.05) 23<S1CU 30 47 1 1.30 ( 0.77- 2.20) 1.16 ( 0.66- 2.04) 1.18 ( 0.65- 2.17) 1.33 ( 0.79- 2.26) 1.04 ( 0.56- 1.95) EXcludfd/Trend 67 134 0.52 0.52 0.56 0.52 0.54 AG€ <55 YEARS Non 6xpossd 0<S1CU<13 3<51CU< 1 23< 23 S1CU Excluded/Trend AGE 55-6-4 YEARS 94 213 7.00 1.00 1.00 1.00 1.00 55 107 1.05 ( 0.66- 1.66) 1.07 1 0.65- 1.76) 1.20 ( 0.66- 2.19) 1.03 ( 0.65- ?.65) 1.13 ( 0.67- 7.90) 2 18 0.17 ( 0.04- 0.80) 0.11 ( 0.01- 0.89) 0.00 ( 0.00•99.99) 0.18 ( 0.04- 0.83) 0.12 ( 0.01- 0.97) 5 6 1.68 ( 0.46- 6.13) 1.27 f, 0.28- 5.83) 1.25 ( 0.27- 5.85) 1.76 ( 0.48- 6.50) 1.34 ( 0.20- 9.15) ~ 9 15 0.59 0.57 0.53 1 0.56 0.59 Non exposstl 95 0<$1CU<13 58 13<SiCU<23 14 23<$1CU 95 Ezcludtd/Trend 2a. AGE 65+ YEARS Non eXpOSStl 108 O<S1CU<.13 ~ 75 13<S1CU<23 ' 20~ 23<S1CU IIII 22 Excluded/Trend( SOi HISTOLOGICALLY CONFIRMED DIAGNOSIS 289 1.00 1.00 i.00 1.00 1.00 140 0.95 ( 0.60- 1.50) 0.87 ( 0.53- 1.42) 0.65 ( 0.37• 1.14) 0.98 ( 0.61• 1.56) 0.77 ( 0.44- 1.33) 26 1.25 ( 0.58- 2.69) 0.93 i 0.40- 2.13) 0.58 ( 0.21• 1.59) 1.26 ( 0.58- 2.73) 0.98 ( 0.40- 2.40) 14 2.88 ( 1.22- 6.79) 2.37 ( 0.96- 5.85)' ( 2 0.78- 5.99) 2.87 ( 1.22- 6.77)I 2.65 ( 0.99- 7.10) B3( 0.02 ~ 0.02 ! .02 0.02 0.02 ) 0.02 276 1.00 1.00 1.00 1.00 1.00 164 1.01 ( 0.68- 1.50) 1.06 ( 0.70- 1.62) 1.18 ( 0.71- 1.97) 1.03 ( 0.69 - 1.54) 1.08 ( 0.69- 1.68) 39 1.04 ( 0.55- 1.95) 0.97 { 0.49- 1.93) 0.65 ( 0.27- 1.56) 1.12 ( - 0.59 2.12) 0.72 ( 0.35- 1.50) 33 1.39 ( 0.74- 2.61) ( 1.52 ) 0.79• 2.91 ( 1.68 0.79- 3.55)j ( 1.43 0.76- 2.69) ( 1.27 0.63- 2.58) ,"r7~ 0.33 0.33 0.26 ; 0.33 0.34 Non exposetl 289 778 1.00 ( 1.00 1.00 1.00 1.00 0<S1CU<13 ( 182 411 0.97 f- 0,76- 1.25)( 0.98 ( 0.75- 1.28) 1.01 ( 0.74- 1.38) 0.99 ( 0.77- 1.28) 0.98 ( 0.74- 1.31) 13<S1CU<.23 35 83 0.87 ( 0.55• 1.36)1 0.78 ( 0.48- 1.28) 0.49 ( 0.26- 0.91) 0.91 ( 0.58- 1.44) 0.69 ( 0.41- 1.16) 23<S1CU ~ 40 55 1.55 (, 0.97- 2.47)! 1.46 ( 0.90- 2.38) 1.49 ( 0.87- 2.53) 1.59 ( 1.00- 2.52) 1.53 ( 0.89- 2.61) EXCluded/Trend S1 215 0.15 1 0.15 0.15 ~ 0.14 ( 0.15 SQUAMOUS CELL CARCINOMA Non axposea 49 778 1.00 1.00 1.00 1.00 1.00 0<S1CU<t3 30 411 0.95 ( 0.56- 1.62) 0.83 ( 0.47- 1.47) 0.86 ( 0.45- 1.63)j 0.93 ( 0.54- 1.59) 0.78 ( 0.42- 1.44) 93<S1CU<23 83 1.02 ( 0.42- 2.50) 0.64 ( 0.21- 1.95) 0.17 ( 0.02- 1.30)1 1.03 ( 0.42- 2.53) 0.43 ( 0.12- 1.52 ) 23eg1 CU 5 55 1.16 ( 0.41• 3.26) 0.67 ( 0.19- 2.36) 0.76 ( 0.21- 2.75) 1.15 ( 0.41- 3.22) 0.50 ( 0.11• 2.30) Excluded/Trand rB 215 0.77 0.77 0.72 ~ 0.77 0.78 SMALL CELL CARCINOMA Non exposed 0<S1CU<13 13<S1CU<23 23<S1CU €xcludod/Trend ADENOCARCINOMA 28 778 1.00 1.00 1.00 ( 1.00 1.00 22~ 411 1.41 r, 0.73- 2.72) 1.39 ( 0.70- 2.76) 1.48 ( 0.70• 3.14) 1.45 ( 0.75- 2.83) 1.36 ( 0.68- 2.71) 7 83 2.42 ( 0.90• 6.52) 2.09 ( 0.73• 5.98)1 2.58 ( 0.86- 7.73) 2.47 ( 0.91- 6.71/ 2.06 ( 0.71- 5,95) ~ 1~ 55 0.37 ( 0.05• 2.92) 0.36 ( 0.04- 2.90) 0.48 ( 0.06- 3.97) 0.36 ( 0.05- 2.91) 0.39 ( 0.05- 3.16) 12 ~>51 0.91 0.87 ~ 0.89 0.91 0.90 expOSeo Non 0<51CU<s13 19<S1CU<23 23 <S1CU .7xcludtd/Trend OTHER 159 778 1.00 1.00 1.00 1.00 1,00 98 ~'11 0.89 ( 0.65- 1.22) 0.91 ( 0.65- 1.27) 0.93 ( 0.63- 1.38) 0.92 { 0.67- 1.27) 0.92 ( 0.65- 1.31) 15 83 0.64 ( 0.35- 1.18) 0.57 ( 0.29- 5.12) 0.31 ( 0.13- 0.78) 0.68 ( 0.37- 1.26) 0.51 ( 0.25- 1.03) 28 851 1.91 ( 1.13- 3.24) 1.87 ( 1.07- 3.27) 1.89 ( 1.02- 3.47) 1.98 ( 1.16- 3.36) 1.87 ( 1.02- 3.42) 33~ 2151 0.08 0.07 0.08 0.08 0.08 Non e%pOS00 53 778 1.00 1.00 1.00 1.00 1.00 0<S1CU<13 32 4111 0.96 ( 0.59- 1.64) 1.09 ( 0.63- 1.88) 1.07 ( 0.57- 2.02) 1.02 ( 0.61- 1.70) 1.13 ( 0.63- 2.03) 13<S1CU<23 6 83 0.75 ( 0.30- 1.91) 0.89 ( 0.35- 2.30) 0.45 ( 0.13- 1.61) 0.80 ( 0.32- 2.04) 0.79 ( 0.28- 2.25 ) 23<S1CU ' 6 55 f 1.32 ( 0.51- 3.44) 1.42 ( 0.54- 3.75) 1.29 ( 0.44- 3.76) 1.38 ( 0.53• 3.59) 2.05 ( 0.74• 5.67) Excl uded/Trend! I 18 215' 0.81 0.84 0.85 0.80 0.82 >7554 OF L)FESPAN IN RURAL AREA OR INTERMEDIATE CITIES Non exposed 0<SiCU<.13 13<S1CU<23 23<S1CU Exaludod/Trend 115 67 17 16 41 270 1.00 136 24 14 131 0.91 ( 0.59- 1.40) 1.36 ( 0.65- 2.86) 2.07 ( 0.90- 4.75) 0.05 >75% OF LIFESPAN IN URBAN AREA 1.00 1.00 0.91 ( 0.59- 1.40) 0.71 ( 0.42- 1.78) 1.36 ( 0.65. 2.86) 0.75 ( 0.28- 2.01) 2.07 ( 0.90- 4.75) 2.16 ( 0.84- 5.56) 0.05 0.04 1.00 0.91 ( 0.59- 1.40) 1.41 ( 0.67- 2.97) 2.14 ( 0.93- 4.92) 0.06 1.00 0.82 ( 0.53- 1.29) 1.06 ( 0.49- 2.30) 1.58 ( 0.65- 3.83) 0.06 - Non exposed I 103 351 1.00 1.00 1.00 ( 1.00 1.00 0<SiCU<13 !- 83 211 1.02 ( 0.69- 1.51) 1.02 ( 0.69- 1.51) 1.21 ( 0.77- 1.90) 1.01 ( 0.68- 1.49) 1.11 l, 0.70- 1.74) 13<S1CU<23 E 10 48 0.54 ( 0.25- 1.15) 0.54 ( 0.25- 1.15) 0.44 ( 0.18- 1.07) 0.58 ( 0.27- 1.25) 0.51 ( 0.21- 1.23) 23<81CU ! 19 34 1.44 ( 0.74- 2.79) 1.44 ( 0.74- 2.79) 1.38 ( 0.65- 2.91) 1.43 ( 0.74- 2.79) 1.75 ( 0.81• 3.79) Excluded/Trendi 29 67 0.68 0.68 0.67 0.68 0.169 (1) ModCl indude sex, ccn(cr, sox'cen(er and age (2) Model indudo sox, center, sex'eenter, age and proportion of residenGal type in the last 35 yrs (REUP) (3) Model (ndude sex, center, sex'center, 3ge, proportion of res dential type in the last 35 yrs (REUP) and educational level (EDUC) (4) Mode( include sex, center, sex'csnter, age and duration of exposure to list A agents (OCLAY) (5) MoUe1 indudo sex. xnter, sex•unter, age and frequency consumption of vegetables (vEGE) -2-063593371 Risk estimates - Spouse +A y

E _S3EV S,Qouse and other oohabitants, ever exposed AU.CENT@RS Lpvel of exposuro ~Cues Controls OR(1) 955G CI Non exposed 260 717 1.00 EXpoaed 388 823~ 1.10 ( 0.89- 1.37) Excludad/Trendl 21 21 ALL CENTERS WiTH EDUCATK)NAL LEVEL AND TYPE OF RESIDENCE Non exposed 166 539 1.00 265 619 1.11 ( 0.85- 1.45) [ Exposed Ercludad/Trandl 571 ALL CENTERS YVfTH D!€TARY DATA Non exposed Exposed 180 OR(2) 95% CI OR(3) 95',G C1 1.00 1.00 1.09 ( 0.87- 1.38) 1.07 ( 0.82- 1.41) 1.00 1.00 1.12 ( 0.85- 1.46) 1.07 ( 0.82- 1.41) OR(4) 95% CI ( 0R(5 1.00 1 1.00 1.12 ( 0.90- 1.40)~ 1.11 ( 0.86- 1.42) E 200 460 1.00 1.00 1.00 1 1.00 1.00 301 575 1.11 ( 0.87- 1.421 1.11 ( 0.86- 1.44) 1.12 ( 0.83- 1.50) 1 1.11 ( 0.87- 1.43) 1.11 ( 0.86- 1.42) &cludad/Trand 8~ 21 1 FRANCE Non exposed E%pOSed 34 49 1.00 1.00 1.00 1.00 1.00 43 102 0.63 ( 0.34- 1.17) 0.43 ( 0.20- 0.88)1 tt 0.37 ( 0.14- 0.97) 0•60 ( 0.32- 1.13) 0.60 ( 0.32- 1.13) Exc1 udod/Trend 01 0 GERAIANY 1 Non exposed Exposed 26 138 1.00 1.00 1.00 1.00 1.00 48 1 91 2.01 { 1.09- 3•70) 2.14 ( 1.09- 4.19) 2.05 ( 1.04- 4.02) 2.10 ( 1.12- 3.94)I 2.20 ( 1.18- 4.13) € I Excluded/Trend _ 2 01 1 ~ 1 E Non exposed 6 0 91 1.00 1.00 1.00 1•00 1.00 Exposed 8 21 72 1.17 ( 0.69- 1.99) 1.09 ( 0.64- 1.87)I 1.03 ( 0.60- 1•78)~ 1.16 ( 0.68- 1.98) ! 1.15 ( 0.67- 1.95) Excluded/Trend+ 0 0 1 1 i E GERMANY y Non exposed E%poSed 21 31 1.00 1.00 l 1.00 1.00 1.00 10 21 0.71 ( 0.25- 2.01) 0.67 ( 0.23- 1.99)~ 0.42 ( 0.13- 1.37)~ 0.62 ( 0.21- 1.84) 0.61 ( 0.21- 1.81) fxcluded/Trend 0 0 ~ ~ Non exposed t 14 103 1.00 1•00 1.00 i-00 Exposed 26 117 0•99 ( 0.46- 2.16)I 1•25 ( 0.55- 2.83) 1 1.17 ( 0.51- 2.69) 1.26 ( 0.55- 2.88) Excluded/Trend 01 t l 111 , 1 ITALY 2 Non exposed Expoaed 10 95 1.00 1.00 1.00 1.00 3I 78 0.36 ( 0.12- 1.19) 111E 0.29 ( 0.08- 1.02) 0.22 ( 0.04- 1.14) 0.37 ( 0.12- 1.14) 8xcludad/Trand : ~ ~ 01 0 ~ ITALY 5 Non exposed ( 3 22 1.00 1.00 1.on ! i.oo 1.00 Exposed ! 13 27 3.02 ( 0.64•14.20)I 2.74 ( 0.56-13.48) 1.51 ( 0.25- 9.00)f 2.52 ( 0.51-12.37) 5.84 ( 1 (. 2xcludad/Trend! 01 ~ PORTUGALI Non exposed 2C 100 . i 1.00 Exposed ~ 29 22 1 .43 ( 0.55• 3.75)~ ~ 1.55 ( 0.57- 4.19) ! Excl udad/Trand E 0! i PORTUGAL 2 0.88-38-87) Non exposed 13 30 1.00 1.00 1.00 Exposed 20 23 2.56 ( 0.91- 7•16)~ 1.88 ( 0.60- 5.90) f 2.57 ( 0.91- 7.24) i fxcludsd/Trendl 01 01 SPAIN Non exposed Exposed 19 35 1.00 1.00 1.00 1.00 1.00 52 f 124 0.73 f, 0.36- 1.47) 0.82 ( 0.38- 1.78) 0.79 ( 0.35- 0.75 ( 0.36- 1.54) 0.75 ( 0 Fxcl udedl7rrnd I 0 0 Non exposed 32 52 1.00 1.00 E 1.00 t 1.00 € Exposed 38 601 1.15 ( 0.61• 2.16)~ 1.13 ( 0.60- 2.15) 1[ 1.17 ( 0.62- 2.21) 1.14 ( 0.60- 2.16) Excluded/Trend 0 E OI UNITED KINGDOM Non exposed 3 Exposed ~ 16 54 1.00 1.00 1.00 1 1.00 1.00 86 1.51 (, 0.59- 3.88) I 1.50 { 0.57- 3.94)1 1.38 ( 0.51- 3.72)I 1.49 ( 0.56- 3.95) 1.60 { 0.61- 4,19) tixcluded/Trendl 0 0 F ~ (1) Mode)1nGude sex, canter, sex'center and age (2) Modal include sex, oenter, sex'centar, age and proportion of residential type in the last 35 yrs (REUP) (3) Motlel hcSude ssx, center, sex'center, ago, propation of residential type in tne last 35 yrs (REUP) and educational level (EDUO) (4) Model include sex, center, sox'c®nter, age and duration of exposure to Iist A agents (OCLAY) M t L41Mnt4_lJarhkiae_~n~rr snyrfn!~~ ~a~~~.odfren,ianrvm mof'rvi ht /Vt=rF1 ) -7 .36- 1.54)

S9 AV Spouse, Average exposure (cigareftes/day) iTALY 2 Yotal Exposed Unacposed Excluded Min P10 ! Qt f Median ( 03 P90 ; Max ( Mean Std I MOn Gs6s 3 0 3 0 €€€ Controls 97 15 82 0 0.91 1.00 2.57~ 3.77 6.71 12.86 ~ 20.00 5.06 5.08 All 100 15 85 0 0.91 1.00 2.57 3.77 5.71 12.86 20.00 5.06 5.08 WortSCl1 CxBs 16 8 7 1 1.50 1.50 2.29 3.57 12.38 40.00 40.00 9.75 13.42 Contr0ls 76 47 24 5 0.16 1.41 2.57 5.14 9.14 19.29 38.57 7.22 7.47 PJI 92 55 81 6 0.16 1.50 2.57 5.14 9.14 19.29 40.00 7.59 8.47 A}1 GSCS 19 8 10 1 1.50 1.50 2.29 3.57 12.38 40.00 40.00 9.75 13.42 Co(itf0ls 173 62 106 5 0.16 i.29 2.57 4.64` 7.14 13.57 38.57 6.70~ 6.99 All 192 70 116 6 0.161 i.35 2.57 4.18I 7.14 18.90 40.00 7.04f 7.90 fTALY 3 MM Cases 1 1 0 0 3.43 3.43 3.43 3.43 3.43 3.43 3.43 3.43 0.00 COntr014 12 2 10 0 0.20 0.20 0.20 0.60 1.00 1.00 1.00 0.60 0.57 All 13 3 10 0 0.20 0.20 0.20 1.00 3.43 3.43 3.43 1.54 1.68 Women CasCS ` 15 9 4 2 2.86 2.86 3.86 5.71 7.86 40.00 40.00 10.06 11.89 ContfGs I 33 15 13 10 0.75 4.50 5.71 10.00 11.43 12.86 30.00 9.95 6.46 A6 53 24 17 12 0.75 3.29 5.04 8.14 11.43 15.71 40.00 9.99 8.64 AH CisCs 16 10 4 2 2.86 3.07 3.43 4.93 7.86 27.86 40.00 9.40 11.41 Controls 60 17 23 10 0.20 0.75 5.57 10.00 11.43 12.86 30.00 8.851 6.79 All 66 27 27 12 0.20 1.00 3.86 7.14 11.43 15.71 40.00 9.051 8.57 PORTUGALI MCn Cises 16 3 13 0 0.13 0.13 0.13 5.001 9.29 9.29 9.29 4.80 4.58 ~ Co11tr01s ~ 8 0 8 0 AN 24 3 1 0 0.13 0.131 0.13 5.00 9,29~ { 9.29' 9.29 4.80 4.58 WM ¢n C85C! 33 16 16 3.14 5.71 7.14 10.29 12.86 22.14 22.14 11.39 5.66 Controls 31 13 17 1 0.10 1.00 2.57 4.57 8.57 10.00 11.431 5.51 3.68 All 64 29 33 2 0.10 1.71 4.57 8.57 11.43 20.00 22.141 8.75 5.64 AII Cases 49 19 29 11 0.13 3.14 6.43 9.86 12.86 22.14 22,14 10.35 5.93 1 ContrOls 39 13 25 1 0.10 1.00 2.57 4.57 8.57 10,00 11.43 5.51 3.68 All 88 32 54 2 0.10 1.71 4.57 8.57 10.86 12.86 22.14 8.38 5.61 Men C3303 10 0 10 0 Conk0ls 17 0 0 171 f All 27 0 27 0 ! 111 I € WIXnCn Giscs 231 14 6 3 0.64 1.00 3.00 6.24 10.001 25.71 45.71 10.45 12.30 CorltfOts 36 12 21f 3 0.44 2.001 4.93 5.93 6.79I 18.11 20.00 7.33 5.82 All I 59 26 27 6 0.44 1.001 3.86 5.93 10.00 20.00 45.71 9.01 9.80 Atl Cases 33 14 16 3 0.64 `:.00 3.00 6.24 10.00 25.71 45.71 10.45 12.30 Controls ~ 53 12 38 3 0.44 2.00 4.93 5.93 6.79 18.11 20.00 7.33 5.82 All i 86 26 54 6 0.44 1.00 3.86 5.93 10.00 20.00 45.71. 9.01 9.80 SPAtN Men Cases 6 1 5 0 3.00 3.001 3.00 3.001 3.00 3.00 3.00f 3.00 0.00 Controls 13 0 13 0 [ 1 Ap 19 18 0 3.00 3.00 3.00 3.003.00j 3.00 3.00 3.001 0.00 IWdttlcn C7sCs 85 30 18 17 1.29 2.00 2.86i 6.00 14.57 21.79 25.82 9.21 7.74 Controls 146 82 37 27 0.50! 1.57 4.001 6.34 12.86 18.18 38.57 8.76 7.73 An 211 112 . 55 44 0.50j ':.71~ 3.00 6.18N 12.86 19.29 38.57 8.88 7.70 All COSCS I 71 31 23 17 1.29 2.00 2.86 6.00 14.57 21.43 25.821 9.01 7.69 I Controls 159 82 50 27 0.50 ?.57 4.00 6.34 12.86 16.18 38.57 8.76 7.73 A11 230 113 73 44 0.50 1.71 3.00 6.07 12.86 19.29 38.57 8.83 7.68 MCn I CasC4 I '3 8 15 0 1.57 1.57 2.50 4.40 5.50 8.371 8.37 4.34! 2.26 Controls j 36 9 27 0 0.89 0.89 4.36 5.00 10.00 11.43 11.43~ 6.00 1 3.78 All ~ 59 7 42 0 0.89 1.29 3.00 ~ 4.57 6.43 10.00 11.43 f 5.221 3.18 WonSCrt UsOs 47 22 3 22 2 0.05 ?.00 2.33 7,68 12.55 20.00 25.71 8.69 7.21 Controls 76 41 35 0 0.05 0.30 2.43 5.00 10.00~ 14.001 41.71 7.16 7.73 All 123 631 58 2 0.05 0.70 2.33 5.57 10.43i 17.14 41.71 7.69 7,531 All Ca3Cf 70 30 38 2 0.05 1.29j 2.33 6.43 8.87 18.57 25.71 7.53 6.54 Controls 112 50 62 0 0.05 0.51j 2.43 5.00 10.00' 13.54 I 41.71 ' 6.95 7.16 A11 102 ®0 100 2 0.05 0.80 2.38. 5.25 9.71i 15.82 41.77 , 7.17 6.90 UNlTED KINGDOM MCt1 CasM 3 0 0 3 Controls ~a o 0 14 ~ ! All 7 0 0 17 W6mon C2SOY 23 0 0 23 ContrGs 126 0~ 0 '26 t ~ { An 149 0 0 149 ~ Al/ C9zCf 26 0 0 26 I f !~ Contras I 140 0 0 140 ~ ~ ! [ f All 166 0 0 166 ; ~ , w CI1!]- ...--

S9AV Spouse, Average exposure (cigaretfeslday) MEN ONLY Total Exposed Unexposed Excluded Min P10 a1 Medien 1 03 ~ P90 Max Mean I Std Men C15Cs 154 22 132 0 0.13 1.57 3.00 4.51 7.00 8.37 10.31 4.82 2.76 Controls ~ 566 58 499 9 0.10 1.00 2.00 4.14 7.18 11.79 25.71 5.52 5.13 All 737 80 631 26 0.10 1.00 2.04 4.35 7.09 10.16 25.71 5.33 4.59 Won1Cf1 CasG 0 0 0 0 ~ Controls 0 0 0 0 ~ All 0 0 0 0 Ak Ci15C3 157 22 132 3 0.13 1.57 3.00 4.51 7.00 8.37 10.31 4.82 2.76 ConU0l9 580 58 499 23 0.10~ 1.00 2.00 4.14 7.18 11.79 25.71 5.52 5.13 All 737 80 631 26 0.10 1.00 2.04 4.35 7.09 10.16 25.71 5.33 4.59 WOMEN ONLY Man Cases Con«ols All 0 0 0 0 0 0 0 0 0 0 0 0 ~ "VO3593399 1 WOfTICn ~.`aSC.3 527 22 57 209 61 0.05 i.50 2.83 5.86 10.00 20.83 53.31 8.65 9.03 Controls 950 $10 371 69 0.05 1.50 3.21 5.61 11.25 18.57 60.00 8.23 7.64 All 1626 767 580 279 0.05 1.50 3.00 5.71 10.71 19.13 60.00 8.37 8.13 All CeSCS 550 257 209 84 0.05 1.50 2.83 5.86 10.00 20.83 53.31 8.65 9.03 Contr013 1076 ~ $10 371 195 0.05 7.50 3.21 5.61 11.25 18.57 60.00 8.231 7.64 AA 1026 767 580 279 0.05 ':.50 3.00 5.71 10.71 19.13 60.00 8.371 8.13 Men CosC9 Conlrols All 91 d44i 535 16 54 i 70 75 383 458 0 7 7 1.47 0.10 0.10 1.57 1.00 1.09 3.00 2.09 2.25 4.70 7.25 4.14! ?.18 4.40f 7.18 8.37 10.31I 5.19' 11.43~ 25.71 5.44' 10.16 25.71 5.39 2.62 4.84 4.41 WOft1Ct1 CasCf 287 142 111 34 0.05 1.50 2.57 5.20 8.96 20.00 53.31 8.15 8.81 [ CotltrOls 506 288 194 24 0.05 1.50 3.00 10.00~ 5.14 16.291 60.00 7.79 7.79 IVI 793 430 305 58 0.05 1.50 3.00 ~ 5.14 9.92i 17.13 60.00 7.91 8.14 AII Cases 378 158 186 34 0.05 1.50 2.57 5.15 8.57 18.51 53.31! 7.85 8.44 Controls 950 342 5771 31 0.05 1.50 ~ 3.00 5.00 9.64 . 15.15 60.00f 7.42 7.45 AII y_ 1328 500 76~ ! 65 1 0.05 1.50 1 2.86 5.00 9.29 15.89 60.00 7.55 7.77 HOSAlTAL ®ASED STUAIES MCn Cases 47 6 41 0 0.13 0.13 2.00 3.21 5.001 9.29 9.29 3.87 3.13 Controls ~ 73 4 68 1 0.20 0.20I 0.60 3.00 12.50 20.00~ 20.00 6.55 9.21 All 120 10 109 0.13 0.16 1.00 c'..21 1 5.00 14.64) 20.00 4.90 5.98 Won1Cn CasC4 199 102 70 27 0.20 2.00 3.00 7.31 12.86 22.14 50.00 9.94 9.62 Controls 379 203 133 43 0.10 1.71 3.86 6.43 12.86 18.57 38.57 8.80 7.20 All 578 305 203 70 0.10 1.83 3.57 6.57 12.86 19.90 50.00 9.18 8.09 Nl CisCf 245 Y08 '11 27 0.13 2.00 3.00 6.66 11.50 22.14 50.00 9.60 9.47 Controls 452 207 201 44 1 0.10 1.291 3.75 6.43 12.86 18.57 38.57 8.76 7.22 All 698 315 312 71 0.10 1.71 3.341 6.43 12.86 19.90 50.00 9.05 8.06 WITHOUT OCCASIONAL SMOKERS MCn CisC3 110 16 94 0 0.13 1.47 2.50 4.79 7.25 9.29 10.31 4.96 2.98 Controls 397 41 351 5 0.101 1.00 2.25 4.00 7.18 12.86 25.71 5.87 5.70 All 518 57 445 16 0.10 1.00 2.25 4.29 7.18 11.79 25.71 5.61 5.06 Won1Cn CaSCS 419 195 170 54 0.10 1.57 2.86 5.29 10.00 20.83 53.31 8.63 9.26 Controls ~ 747 390 297 60 0.06 1.50 3.00 5.57 10.99 18.34 60.00 8.19 7.73 All 1240 565 467 188 0.06~ 1.50 3.00 5.53 10.18 19.13 60.00 8.34 8.27 AIl CiSC3 b42 211 264 67 0.10 1.57 2.86 5.25 10.00i 20.00 53.31 8.35~ 8.99 ContrClS 1216 431 648 137 0.06f 1.50 3.00 5.43 10.71 17.96 60.00 7.971 7.59 All 1758 642 912 204 0.06 1.50 3.00 5.29 10.00 18.57 60.00 8.10 S.O' AGE <S5 YFARS Men Cases Controls 56 9 47 0~ 1.47 1.47 3.43 6.75 7.50 10.31 - 10.31 6.19 2.97 1701 22 143 5 0.20 1.00 2.25 4.68~ 7.18 9.64~ 11.79 4.89 3.24 All 229 31 190 8 0.20 1.00 2.71 5.00 7.50 9.64 11.79 5.26 3.17 WOn1Cn Cases J38 61 69 8 0.10 1.18 2.83 5.34 10.00 22.14 40.00 ".07I 8.2E Conltoff 264 124 1191 11 0.10 1.79 3.86 7.14 12.96~ 20.00~ 40.00 9.38 7.71 Atl 392 185 188 19 0.10 1.50 3.29 6.43 11.43 20.00 40.00 8.95 7.9C All CaSCf j Controls 195 426 621 70 146 216 116 262 378 9 0.10 18~ 0.10 27 0.10 1.23 1.50 1 1.30 2.86 3.37 3.18 5.79 10.00 8.68 11.43 6.28 11.15 21.07 19.291 19.29 40.00 40.00 40.00 7.83 8.71 8.42 7.81 7.3E 7 5: 52 7 45 0 0.13 0.13 2.00 4.35! 7.00 8.37 8.37 4.24 2.8< 216 15 198 3 0.89 1.18 1.29 3.75~ 10.00 13.39 20.00 6.05 5.6- AN 268 22 243 3 0.13 1.18 2.00 4.05 7.301 12.86 20.00 5.47 4.9E Wo(imen Cascs 165 83 65 18 0.05 2.00 l 2.57 7.47 11.25 19.49 50.00 8.79 8.7E COnlrOl3 304 167 112 25 0.10 50 1 3.00 5.14 10.00 16.18 41.71 7.63 7.0' All 535 250 177 108 0.05 i : 1 50 3.00 5.70 10.00 17.86 50.00 8.02 7.'E All CasCf 228 90 110 28 0.05 1.94 2.57 6.43 10.29 1 19.17 50.00 8.43 8.5°, COnU01f 575 182 310 83 0.10 `:.50 3.00 5.14 10.00 15.81 41.71 7.50 6.9' 803 272 420 111 0.05 '..50 2.93 5.23 10.00 17.11 50.00 7.81 7.4'_ AGE 6S+ YEARS Mcn Cssas 461 6 40 0 1.571 1.57 2.00 3.73 4.57 5.00 5.00 3.43 1.4E Controls 180 21 158 1 0.10 1.00~ 2.00 3.91 6.96 11.43 25.71 5.80 6.38 All 1 240 27 198 15 0.10 1.001 2.00 3.91~ 6.00 11.43 25.71 5.28 ^ 7: 223 113 75 35 0.20 2.00 2.86 5.29 10.00 21.43 53.31 8.87 9.6- , Con«as 392 219 140 33 0.05 1.41 3.14 5.25' 10.71~ 17.68 60.00 8.03 8.0' 699 332 215 152 0.05 1.50 3.00 5.25 10.00 18.57 60.00 8.32 8.6( Atl CaSCs 284 119 i 115 50 0.20 2.00 2.86 5.16 10.00 21.43 53.31 8.59 9.4E ~ 856 240 298 it7 0.05 1.22 3.00 5.14 10.00 17.05 60.00 7.84 7.9( 939 359 a13 167 0.05 1.50 3.00 5.141 10.00 18.57 60.00 8.09 8.4;

E _swev Spouse and workplace, ever exposed Exc1 udsd/Trand Cases ( Contmis / OR{9) 9574 CI ; OR(2) 95% C7 ) OR(3) 95% C€ I OR141 95% CI I ORfSI 95X Ci ( 527f 1201 1.14 ( 0.88- 1.47)6 1.10 ( 0.84- 1.44)1 1.09 ( 0.80- 1.49)~ 1.17 ( 0.91- 1.52)~ 1.11 ( 0.82- 1.50)~ 122 339 1.00 1.00 .00 1.00 ! 1.00 ALL CENTERS WiTH EDUCATIONAL LEVEL AND TYPE OF RESIDENCE Non expossd Exposrrd 79 352 Excludsd/Trsndj 67 ALL CENTERS SMTH DIETARY DATA Non oxpossd 8 2 I 1.00 1.00 -T-00 1 1.00 1.10 ( 0.81- 1.50) 1,09 ( 0.80- i.49) 1.11 ( 0.81- 1.51)j 1.11 ( 0.80- 1.56) 1a9 1.00 1.00 1,00 1.00 1.00 Exposed 420 845 1.12 ( 0.83- 1.52) . 1.13 ( 0.82- 1.54) 1.11 ( 0.79- 1.55) f 1.13 ( 0.83- 1.53) 1.11 ( 0.82- 1.50)~ Excludsd/Trsnd 7 P2 ~ € E Non exposed 22 33 1.00 1.00 1-00 € 1.00 1.00 Exposed 55 118 0.72 ( 0.38• 1.36) 0.60 ( 0.29- 1.25) 0.70 ( 0.28- 1.80) 0.73 ( 0.38- 1.40)~ 0.69 ( 0.36- 1.32) Excludad/Trand 0 Non expos.d 12 31 1.00 1.00 . 1.00 1.00 1.00 ExposOd 63 198 ~ 0.88 ( 0.40- 1.95) 0.87 ( 0.36- 2.08) 0.89 ( 0.37- 2.14) 0.85 ( 0.37- 1.95) 1.01 ( 0.45- 2.28) Excludad/Trsnd '~ 0 ~ Non .xposad 23 35 1.00 1.00 1.00 1.00 1.00 ExpoSSd € 119 128 1.22 ( 0.66- 2.23) 1.22 ( 0.67- 2.25) 1.16 ( 0.63- 2.16) ~ 1.23 ( 0.67- 2.25) 1.20 ( 0.66- 2.21)~ 1 .kcludsd/rrand( a ai F Non exposed 10 49 1.00 1.00 1.00 1.00 ( ! Exposed 30 172 0,73 ( 0,32• 1.66) 1.02 ( 0.41- 2.53) 0.95 ( 0.38- 2.40) 0.92 ( 0.38- 2.23) 1 Excludad/Trand 01 ? Non exposed 5 59 1.00 1.00 1.00 1.00 ° € ExposQd 14 114~ 1.12 ( 0.35- 3.56) 1.00 ( 0.28- 3.60) 2.86 ( 0.47-17,32) 1.03 ( 0.32- 3.31) Exc1 udad/Trend ~ 0 0! 1 1 ITALY 3 von •xposao Exposad 3 14! 1.00 1.00 1.00 1-00 1.00 13 35~ 1,39 ( 0.30- 6,4$) 1.29 ( 0.24- 6.85) 0.63 ( 0.10- 4.02) 1.27 ( 0.26- 6.16) 2.08 ( 0.3313.12) Excluded/Trmdl 0 tll 1 € 1. [ PORTUGALI on .xposao 11 N Expoa®d ~ 38 F ud rend 0 xc1 ad/T ~ 13€ 1.00 s.oo <'6 2.04 ( 0.71- 5.80) 2.22 ( 0.77• 6.37) 0 ~ PORTUGAL3 Non exposed Exposed Excludad/Trsndl 0 SPAIN Non exposed 8 Exposed 63 Excludsd/Trendi SWEDEN Non exposed Exposed Exc2udad/Trandi 20 138 € I I 4 10 1.00 1.00 1.00 1.Do 66 102 2.29 ( 0.65• 8.07) 2.30 ( 0.65- 8.09) 2.07 (, 0.59- 7•30) 2.37 ( 0.67- 8.34) 0 B! UNITED K)NGDOM Non exposad 4 28 1.00 1.00 1. 00 ! 1.00 i 1.00 Exposed 22 112 1.35 ( 0.43- 4.28)~ 1.23 ( 0.38- 3.98) 1.21 ( 0.37- 3.91) 1-22 ( 0.38- 3.92)~ 1.29 ( 0.41- 4.13) €xciuded/Trand 0! 0 1 1 E ~ € (1) Model inUud@ s®x, conter, sox'center and age (2) Modal ktcludo sex, cantar, sex'conter, age and proportbn of residential type in the last 35 yrs (REUP) f3)1~1cde17ndude sax, center, sntc'canter, age, proportion of residential tvpe in the last 35 yrs (REUP) and educational level (EDUC) (4) Model indudo sax, cantor, sax'center, age and duraGon of exposure to list A agents (OCLAY) (5) Model Includa sex, center, aex'c©ntor, age and frequency consumption of vegetables (vEGE) 1.00 2.15 ( 0.79- 5,85) 0 1.00 i 1.00 1.00 1-00 1.00 1.10 f, 0.46- 2.66)~ 1.08 ( 0.44- 2.65) 0.95 ( 0.38- 2.38) 1.13 ( 0.47- 2.73)1 1,21 ( arnncntac

WOTS `dVorkplace, Time since last ETS exposure (years) ALL CENTERS Total Exposed Unexposed I Exduded Min P10 C11 ° Median I 93 FS0 Max ~ Mean Std MCn C35tS 141 104 36 1 0.00 0.00 0.00 5.00 14.50 31.00 52.00 9.97 12.8 Controls 531 379 152I 0 0.00 0.00 0.00~ 6.00~ 17.00 31.00 54.00 10.63 12.7 AH 672 483 988f 1 0.00 0.00 0.00f 6.00f :6.00 31.00 54.00 10.48 12.7 Won1iX1 CSSCS 309 268 240 1 0.00 0.00 1.00 9.00 23.50 39.00 57.00 14.30 15.3 Conlrolf 1011 475 535 1 0.00 0.00 2.00 14.00 33.00 44.00 57.00 18.27 16.6 A11 1520 743 77S 2 0.00 0.00 2.00 12.00 30.00 42.00 57.00 16.84 16.2 All CWS 650 372 276 2! 0.00 0.00 0.00 7.50 20.501 38.00! 67.00 13.09 14.7 Controls 1642 854 687 1I 0.00 0.00 1.00 10.00 26.00 41.001 57.00 14.88 15.4 AII 2192 1226 963 31 0.00 0.00 0.00 9.00 24.00 39.00 57.00 14.34 15.2 ALL CENTERS WfTH EDUCATIONAL LEVEL AND TYPE OF RF.SIDENCE MCr1 Cases 92 67 24 1 0.00 0.00 0.00 4.0 0 15.00 38.00 52.00 10.25 13.7 Conuolf 470 335 135 0 0.00 0.00 0.001 6.0 01 17.00 32.00 54.00 10.83 12.9 NI $62 402 159 1 0.00 0.00 0.001 6.00 16.00 32.00 54.00 10.74 13.0 Women 1 57.00 16.45 16.0 Conlrolf 068 399 468 1 0.00 0.00 ~ 2.00 16.00~ 35.00 45.00 5 7.00E 19.31 17.0 Al) 1274 602 670 2 0.00 0.00 2.00 14.00 33.00 43.00 57.00 18.35 16.7 AN Ci3e5 496 270 226 2 0.00 0.00 1.00 10.00 25.00 40.00 57.00 14.92 [ 15.7 Controls 1338 734 603 1 0.00 0.00 1.00 10.00 28.00 4"I.00 57.00 15.441 15.E AH 1836 1004 829 3 0.00 0.00 1.00 10.00 27.00 41.00 57.00 15.30 15.E ALL CENTERS WITH DIETARY DATA M,ert CiasC3 104 81 22 1 0.00 0.00 0.00 5.00 16.00 31.00 52.00 10.59 ... . ContfG9 306 238 68 0 0.00 0.00 0.00 6.00 ~ 19.00 33.00 52.00 11.49 13.3 All 410 319 90 0.00 0.00 0.00 6.00 17.00 33.00 52.00 11.26 13.3 Worflan C2sef 405 224 180 1 0.00 0.00 9.50 10.00 25.00 39.00 57.00 14.75 15.4 Controff 760 401 348 0.00 0.00 4.00 17.00 33.00 44.00 57.00 19.19 16.5 AIl 1155 625 528 2 0.00 0.00 2.00 13.00 30.00 43.00 57.00 17.60 16.3 Atl Cesas 509 305 202 2 0.00 0.00 1.00 8.00 22.00 39.00 57.00 13.65 15.6 Controls 1056 639 416 1 0.00 0.00 2.00 11.00 28.00 42.00 57.00 16.32 15.8 All 1565 944 618 3 0.00 0.00 1.00 10.00 27.00 41.00 57.00 15.46 15.E FRANCE Man Cases 14 7 6 1 0.00 0.00 0.00 4.00 8.00 44.00 44.00 8.85 15. t Controls 23 12 11 0I 0.00 0.00 0.00 8.00 15.00 20.00 46.00 10.67 13.' All 37 19 17 1 0.00 0.00 0.00 5.00 15.00 44.00 46.00 10.00 13.' Women Cise3 63 30 32 1 0.00~ 0.00 0.00 3.00 14.00 30.50 44.00 8.90 13.:. COnlydf 128 61 S7 0 0.00! 0.00 2.00 8.00~ 24.00 30.00 42.00 13.16 12.8 All 191 91 99 9 0.00 0.00 6.001 21.00 30.00 44.00 11.76 12.6 All Cise3 77 37 38 2. 0.00 0.00 0.00 3.00 13.00 42.00 44.00 8.89~ 13._ Controls 151 73 78 0 0.00 0.00 2.00 8.00 22.00 30.00 46.00 12.75~ 12.8 All. 226 110 116 2 0.00 0.00 0.00 '.00 19.00 31.50 46.001 11.451 13.0 Men Cases 8 17 0 0.00 , 0.00 0.00 3.00 13.00 28.00 31.00 7.59 1G c 1 Controls 129 108 21 0 0.00 0.00 0.50 8.00 21.00 33.00 52.00 12.131 13 J AIl 1471 125 22 0 0.00 0.00 0.00 7.00 18.00 33.00 52.00 11.51 12 ; WorrlCn CASa4 38 40 18 0 0.00 0.00 3.50 13.00 30.50 42.50 57.00 18.28 16.4 Controls 1 100 ?5 25 0 0.00 0.00 5.00 18.00 37.00 45.00 54.00 20.84 1E : All 158 115 43 0 0.00 0.00 5.00 17.00 34.00 45.00 57.00 19.95 16 : AII CaSaf 76 57 19 0 0.00 0.00 2.00 11.00 27.00 36.00 57.00 15.09 1: • Cortuolf 29 183 2 46 0 0.00 0.00 2.00 10.00 l 00 28. 39.00 54.00 15.70 1 15.: AI1 305 240 65 0 0.00 0.00 2.00 10.00 27,50 39.00 57.00 15.55 15.: GERMANY2 Man Casef 29 Controls I 65 19 10 0 0.00 0.00 0.00 0.0 0 13.00 40.00 52.00 8.05 t4.c 50 15 0 0.00 0.00 0.00 1.00 1 20.00 34.00 47.00 10.70 ta.E All 94 69 25 0 0.00 0.00 0.00 0.001 17.00 34.00 52.00 9.97 14.E WOrt1Cn C851' 3 p 113 59 54 0 0.00 0.00 1.00 12.00 32.00 43.00 5 3.00 7.00 17.t Controls 98 51 47 0 0.00 ~ 0.00 5.00 21.00 38.00 47.001 55.00 . 22.82 17.E All ~11 110 101 0 0.00 0.00 2.00 16.50 36.00 45.00 55.00 19.70 17.~ A!i :- CaaSCS 142 Controls 183 AIl 30S 78 101 t79. 64 62 126 0 0 0 0.00I 0.00' 0.00 0.00!!!Ef 0.00 0.00 0.00I 0.00 0.00 8.50 13.00 10.00 27.00 43.00I 53.00~ 32.00 42.00'ff 55.00'€ 32.00~ 43.00 55.00 14.82 16.82 15.95 16.€ 17.: 17.' vERMANY3 Men C03a3 Controls 10 8 2 0 2.00 2.00 2.50 24.00 39.50 46.00 46.00 22.50! 19.e ~ 14 9 5 0 0.00 0.00 1.00 3.00 20.00 45.00 45.00 12.441 15.- AIl 24 ".7 0 0.00 0.00 2 00 10.00 38.00 45.00 46.00 17.18 17.` WoRtart Casas 21 10 11 0 0.00 0.00 2.00 4.50 17.00 21.50 24.00 8.20 8.e Controls 381 15 23 0 1.00 2.00 3.00 12.00 30.00 49.00~ 56.00 17.67 18.• All _59 25 34 0 0.00 1.00 3.00 ".00 19.00 42.00~ 56.00 13.88 15.' Afl GisCS 31 18 13 0 0.00' 0.00 2.00 7.00' 24.00 40.00 46.00 14.56 15.5 Controls 52I 24 28 0 € 0.001 1.00 ! 2.50~ 8.001 I 24.00 45.00 56.00 15.71 17.: AII 8 i3 42 41 0 0.001 t.oo 2.001 7.00 24.00, f 42.001 56.001 9s.21 16. ITALY I Man Casof 8 5 3 0 1.00 1.00 4.00 8.00 9.00 21.00 21.00 8.60 Controls 103 74 29 0 0.00 0.00 0.001, 7.50 16.00 31.00 50.00 10.85 92. F All 111 79 32 0 0.00 0.00 0.00 8.00 16.00 31 .001 50.00 70.71 12.- Wonlan C9sef ff 32 _ 13 19 0 0.00 0.00 7.00 15.00 25.00 43.00 48.00 18.62 16 .: Controls ~ 118 39 79 0 0.00 0.001 0.001 9.00 30.00 41.00 49.00 14.95 16.: All 150 52 98 0 , 0.001 0.00 0.00 11.00 30.00 ~ 41 .00 49.00~ 15.87 96._ Nl C3Sa. 40 18 22 0 0.00 0.001 4.00 11.00 22.00 !! 43.00 48.00 15.83 94. ? Controt3 221 113 108 0 0.00 0.00 0.00 o s.C 17.00 I 37.00 50.00 12.27 14. All 261 131 130 0 0.00 0.00 0.00 5. 001 21.00 i 38.00 50.00 12.76 14.. 2063593405 Descnptive statistics - Workplace

WOWD Workplace, Weighted duration (hours x level) FqSTQLOGICALLY CONFIRMED DIAGNOSIS ToW Exposed Unexposed ~ Exduded Min ( P10 ~ 01 Median ~ 03 P90 Max / Mean Std I Men C95C3 152 88 47 17 286.00 884.00 3650.40 14625.52 29016.00 59280.00 207792.00 21620.50 29295.77 C0ntr015 680 307 192 81 10.40 1123.20 3120.00 9152.00! 18720.00 35880.00 198016.00 15348.66 22227.82 All 732 395 239 98 10.40 1040.00 3120.00 9599.20 20800.00 37440.00 207792.00 16745.93 24084.49 WOntcn Ca3ta 331 199 268 64 31.20 520.00 2080.00 6864.00 19968.00 39803.64 142355.20 15748.81 22759.75~ Controls 1078 404 599 73 20.80 520.00 1664.00 4992.00~ 14560.00 29484.00 179712.00 11669.57 19059.371 A11 1807 603 867 137 20.80 520.00 1820.00 5408.00 16130.401 33592.00 179712.00 13015.79 20426.41 AN Cases 683 287 315 81 31.20 624.00 2210.00 7800.00 23400.00 46020.00 207792.00 17549.19 25040.94 Controls 1656 711 791 154 10.40 780.00 2080.00 6240.00 16640.00 31824.001 198016.00 13258.151 20553.68 AA 2339 998 1106 235 10.40 748.80 2080.00 6552.00 18304.00 35796.80 207792 00 14492.15 22011.281 SQUAMOUS CELL CARCINOMA Men CSSCS 28 13 10 5 364.00 1924.00 3556.80 7280.00/ 27040.00 47283.33 91338.00 20080.78 25861.41 Controls 580 307 192 81 10.40 1123.20 3120.00 9152.00, 18720.00 35880.00 198016.00 15348.66 ~ 22227.8 2 Ah 808 320 202 86 10.40 € 1185.60 3120.00 9152.00' 19136.001 36036.00 198016.00 15540.91 f 22360.14 WOmen C9SCi 97 37 49 11 31.20 260.00 3744.00 9828.00 25958.401 49982.40 120120.00 19551.82 24428.93 COnlrol: 1076 404 599 73 20.80 520.00 1664.00 4992.00 14560.00 29484.00 179712.00 11669.57 19059.371 All 1173 441 648 84 20.80 520.00 1716.00 5200.00 14976.00 31200.00 179712.00 12330.90 19655.17 Al Cases 125 50 59 16 31.20 494.00~ 3556.80 9139.00 27040.00 48632.86 120120.00 19689.35 24541.62 CIX1trOlS 1656 711 791 154 10.40 780.00 2080.00 6240.00 16640.00 31824.00 198016.00 13258.15 20553.68 All 1781 761 850 170 10.40 759.20 2080.00~ 6240.00 17305.60 33280.00 198016.00 13680.70 20881.45 SMALL CELL CARCINOMA MCn C85EL 14 10 3 1 312.00 598.00 14976.00 22880.00 59280.00 86320.00 101920.00 33732.40 33040.44 COntr01S 580 307 192 ^01 10.40 1123.20 ~ 3120.00 9152.00 18720.00 35880.00 198016.001 15348.66 22227.82 AN 594 317 195 82 10.40 1045.20 3120.00 9599.20 19344.00 36275.20 198016.00~ 15928.59 22801.10 Women USeS 67 20 36 11 248.10 400.40 2080.00 3510.00 11980.80 27508.00 34944.00 8457.46 10672.021 COnUGf 1076 404 599 'a3 20.80 520.00 1664.00~ 4992.00 14560.00 29484.00 179712.00 11669.57~ 19059.37 AH 1143 424 635 84 20.80 520.00 1664.00~ 4680.00 14560.00 29484.00 179712.00 11518.06' 18752.73 AII CaSef 81 30 39 12 248.10 400.40 2080.00 798.00 22256.00 47112.00 101920.00 16882.44 23670.00 Controls 18561 711 791 154 10.401 780.00 2080.00 6240.00~ 16640.00 31824.00 198016.00 13258.15 20553.68 All 1737 741 830 166 10.40 759.20 2080.00 6240.00 16848.001 32448.00 198016.00 13404.89 20683.20 ADENOCARCINOMA Mcn Cases ~ Controls AIl 80 580 660 47 307 354 27 192 219 6 81 87 286.00 10.40 10.40 769.60 1123.20~ 982.80 2516.60 3120.00 3120.00 9568.00 9152.00 9152.00 29952.00 18720.00 19760.00 41600.00 35880.OOI 35880.00 67392.00 198016.00 198016.00 16683.21 17561.19 15348.66. 22227.82~ 15525.85 21649.15 WOmcn Cases 281 104 46 31 35.20 634.40 2912.00 7384.00 16640.00 39000.00 131040.00 15321.18) 21675.05 Controls 1076 404 599 73 20.80 520.00 1664.00 4992.00 14560.00 29484.00 179712.00 11669.57~ 19059.37 AN 1357 508 45 104 20.80 520.00 1820.00 5408.00 14768.00 31200.00 179712.00 12417.15 19656.151 AII Cases 361I 151 173 37 135.20 769.60 2912.00 7488.00 21710.00 39000.00 131040.00 15745.12 20434.681 Controls 1856 711 791 154 10.40 780.00 2080.00 6240.00 16640.00 31824.00 198016.00 13258.15 20553.681 A11 2017 862 964 191 10.40 780.00 2178.80 6520.80 17160.00 34320.00 198016.00 13693.81 20542.83>. OTHER Men Cases Controls AU 30 580 610 18 ' 307f 192 325 199 S 81 86 1216.80I 10.40I 10.40 1248.00 1123.20 1248.00 4472.00 18158.40 28080.00 3120.00 9152.00 18720.00 3120.00 9547.20 19136.00 60840.00 207792.00 28895.53 47917.78I 35880.00 198016.00 15348.66 22227.82 36192.00 207792.00 16098.95 24428.13 WOn1Cn CiSCS 86 38 37 11 124.80 436.80 1196.00 3692.00I 21840.00 56160.00 142355.20 17053.76 27921.27( Controls 1076 404 599 3 20.80 520.00 14560.00 1664.001 4992.00 i 29484.00 179712.00~ 11669.571 19059.37 All 1162 442 636 84 20.80 520.00 € I 1560.00 4784.00 14976,00 31200.00 179712.00~ 12132.471 1999L25~ AH Cases Controls All 116 1656 1772 561 44 711 791 767 835 16 154 170 124.80 10.40 10.40 520.00 780.00 759.20 1432.60~ 7155.20 25012.00 2080.00 6240.00 16640.00 2080.00 6240.001 17305.60 56160.00 207792.00 20860.04 35571.141 31824.00( 198016.00 13258.151 20553.68 33280.00 207792.00 13813.18! 22053.041 >75N. OF LIFE5PAN IN RURAL AREA OR INTERMEDIATE CITIES MGn Ca5¢3 76 33 37 6 286.00 624.00 936.00 7280.00 21840.00 47283.33 91338.00 16240.69 20923.95 Conlf019 225 97 97 31 78.00 748.80 1560.00 6110.00 17316.00 37440.00 198016.00 15407.65 25970.98 All 301 130 134 37 78.00 686.40 1560.00 6175.00 19136.00 37856.00 198016.00 15619.12 24712.03 WOmGn 237 66 141 30 260.00 520.00 2080.00 4758.00 16380.00 32760.00 120120.00 12821.621 19514.65 , Controls 462 165 271 ?6 62.40 520.00 1752.40 4992.00 14040.00 30160.001 159120.00 11407.40f 19064.47 A41 699 231 412 56 62.40 520.00 1872.00 4836.00 14040.00 30160.00 159120.00~ 11811.47f 19162_25 Afl Cases 313 99 178 36 260.00 520.00 1976.00 5720.00 19656.00 34944.00 120120.00 13961.31 19954.17 Controls 687 262 368 57 62.40 748.80 1664.00 5174.00 14950.00 32760.00 198016.00 12888.41 21913.73 Atl 1000 361 546 93 62.40 624.00 1752.40 5200.00 15600.00 32760.00~ 198016.00 13182.64~ 21372.26 >7354 OF UFESPAN IN URBAN AREA MCM CSSCS 48 33 7 8 561.60 1664.00 4472.00 14847.04 31200.00 60840.00 207792.00 26320.16 38127.68 i CIX1Ir0If I 257 157 72 28 10.401 1788.80 4004.00 9672.001 18470.40 32448.00 119808.00 14065.89 15592.23 AU i~ 305 190 79 36 10.40 1726.401 4004.00 9932.001 20841.60 35448.40 207792.00 16194.26 21644.09 WOn1Cn Cases 196 83 87 26 31.20 520.00 2329.60 7072.00 21257.60 42120.00 142355.20 16746.81 25539.51 Controls 454 176 250 28 20.80 520.00 1651.00 5434.00 16432.00 29484.00 179712.001 12864.81 20992.89 ~Afl 650 2591 337 54 20.80 520.00 1996.80 5954.00 17160.00 38454.00 179712.001 14108.85 22572.76 Atl 1 C3565 244 116 94 34 31.201 769.60 2795.00 7486.00 27092.00 46550.40 207792.00 19470.27 29806.471, Controls 711 333 322 56 10.40~ 832.00 2496.00 7425.60 17472.00 30160.00 179712.00 13431.08 18625.09 ~ AN 955 449 416 90 10.40 780.00 2496.00 7488.00 18720.00 35796.80 207792.00 14991.32 22184.07 2063593404

L_Y' I Spouse, Average exposure (cigarettes/day) MEN ONLY LOVO3 of cx oSUte S1AV<10 SiE.I 10<S1AV<.18 98<$1AV CaseS Control5 OR(1) 95% Ci OR(2) 95» Ct OR(3) 95 % C1 °a OR 4 95 ti CI { ORIS) 95•. Ct ~ 138 502 1.00 1.00 1.00 1.00 1.00 0 4 0.00 ( 0.00-99.99) 0.00 ( 0.00-99.99) 0.00 ( 0.00-99•99) 0.00 ( 0.00-99•99) 0.00 ( 0.00-99.99) 0 3 0.00 ( 0.00-99.99) 0.00 ( 0.00-99.99) ~ 0.00 ( 0.00-99.99) 0.00 ( 0.00-99.99) 0.00 ( 0.00•99.99) ~ Exc1 uded/Trand 31 22 0.98 0.98 0.98 0.98 0.98 ~ WOMEN ONLY NE., S1AV<.10 365 687 1.00 1.00 1.00 1•00 1.00 1o<$1AV<.1s 25 79 0.57 r, 0.35- 0.91) 0.52 ( 0.31- 0.87) 0.50 ( 0.28- 0.89) 0.57 ( 0.35• 0.92) 0.49 ( 0.29- 0.84) 98<81AV 35 52 1.34 ( 0.84- 2.12) 1.29 ( 0.80- 2.08) 1.40 ( 0.80- 2.45) 1.35 ( 0.85- 2.14 } 1.17 ( 0.68- 2.00) E~c2udrd/Trrnd 84 193 0.94 1 0.94 0.96 0.94 0.96 POPULATiON 9ASED STUDIES NE., 31AV<10 314 844 1.00 1.00 1.00 1.00 1.00 t0<61AV<.18 14 48 0.49 (, 0•26- 0.93) 0.52 ( 0.27- 0.98) 0.48 ( 0.23- 1.01) 0•50 ( 0.26- 0.94) 0.52 ( 0.26- 1.03) 18<S1AV 16 27 1.21 ( 0.62- 2.38) 1.25 ( 0.63- 2.46) 1.21 ( 0.55- 2.64) 1.22( 0.62- 2.39) 1.08 ( 0.49- 2.41 ) €xcludad/Trend 04 31 0.47 0.46 0.52 0.46 0.46 HOSPITAL BASED STUDIES NE., S1AV<•10 10<$tAV<18 18<S1AV Excludid/Trondl 271 44 WiTHOt1T OCCASIONAL SMOI<ERS NE., S1AV<10 377 10<S1AV<18 1 18 18<$1AV 26 1.00 ( 1.00 1.00 1.00 0.49 ( 0.21- 1.16)~ 0.51 ( 0.20- 1.31) 0.63 ( 0.31- 1.30) 0.42 ( 0.18- 0.99) 1.25 ( 0.64- 2.45) 1.60 ( 0.71- 3.60) 1.42 ( 0.76- 2.65) 1.20 ( 0.58- 2.47) 0.72 0.71 1 0.65 866 1.00 1.00 1.00 i.00 1.00 62 0.46 ( 0.26- 0.84)~ 0.38 ( 0.20- 0.73) 0.42 ( 0.22- 0.83)~ 0.47 ( 0.26- 0.84) 0.35 ( 0.17- 0.70) l 42 1.23 ( 0.72- 2,10) 1.17 { 0.67- 2.04) 1.23 ( 0.65- 2.33) 1.25 ( 0.73- 2.13) 1.05 {. 0.56- 1.96) €xcltrded/Trand 67 134 0.58 1 0.58 ~ 0.62 ~ 0.57 0.57 AGE <55 YEARS NE, S1AV<10 143 306 1.00 1.00 I 1.00 1.00 1.00 f 10<S1AV<•te ' S 24 0.38 ( 0.14- 1.06) 0•36 ( 0.11- 1.12) 0•33 (- 0.09- 1.24) 0.40 ( 0.15- 1.13) 0.40 ( 0.13- 1.26) 18<81AV 8 16 0.94 ( 0.37- 2.37) 0.74 ( 0.26- 2.09) 0.77 ( 0.21- 2.80) 0.97 ( 0.38- 2.46) 0.78 ( 0.25- 2.44) Excludld/TrOnd 9 15 0.31 ~ 0.29 0.28 ~ 0.31 0.31 AGE 55-64 YEARS NE., S1AV<.10 161 428 1.00 7.00 1.00 1-00 1.00 10<$1AV<a18 ~ 10 26 0.80 ( 0•36• 1.81) 0•58 ( 0.23- 1.46) 0.66 ( 0.25- 1.71) 0.80 ( 0.35- 1.79) 0.65 ( 0.26- 1.63) 18<$1AV 11 15 1.86 ( 0.79- 4•40) 1.77 ( 0.73- 4.33) 2.03 ( 0.61- 6.74) 1.82 ( 0.77- ~ 4.30) 1.70 ( 0.63- 4.59) t Excladed/Trrndj 28 83~ 0.37 0.06 ~ 0.37 0.36 ! 0.35 ( AGE 65+ YEAR$ NE, 51AV<10 199 455 1.00 1.00 1.00 1,00 1.00 10<S1AV<i9 ~ 10 33 0.50 ( 0,24- 1.07) 0.54 ( 0•25• 1.15) 0.47 ( 0.19- 1.16) 0.50 ( 0.24- 1-07) 0.44 ( 0.19- 0.98) 18<S1AV 16 24 1.39 ( 0.69• 2.77) 1.48 ( 0.73- 2.99) 1.61 ( 0.75- 3.50) 1.40 ( 0.70- 2.79) 1.09 ( 0.49- 2.39) gxclUdrd/Tr?nd! a01 117 0.96 0.95 0.90 0.96 ~ 0.98 HISTOLOGICALLY CONFIRMED DIAGNOSIS NE S1AV<.10 488 1189 1.00 1•00 1.00 1.00 1.00 10<$tAV<.18 25 83 0•55 ( 0.34- 0.88) 0.51 1 0.30- 0.84) 0.49 ( 0.28• 0.88)i 0.55 ( 0.34- 0.89) 0.48 ( 0.28- 0.82) 18<$tAV ~ !! 33 55 1.26 ( 0.79- 2.01) 1.22 ( 0.75- 1.98) 1.36 ( 0.78- 2.37)I 1.27 ( 0.80- 2.03) 1.13 ( 0.66- 1.94) r'xcludad/Trend~ 811 215 0.70 0.70 ~ 0.73 ~( 0.70 0.77 SQUAMQUS CELL CARCINOMA NE.i $tAV<t0 81 1189 1•00 1.00 1.00 1.00 1.00 10<S1AV<.18 5 €3 0.72 ( 0.27• 1.88) 0.48 ( 0.14- 1.59) 0.60 ( 0.17- 2.05) 0.72 ( 0.28- 1.90) 0.31 ( 0.07- 1.32) 18<$tAV 5 55 1.29 ( 0.48- 3.46) 1.08 ( 0.37- 3.17) 1.17 ( 0.33- 4.15) 1.29 ( 0.48- 3.46) 0.61 ( 0.14- 2.65) EXC1(ldrd/TrOndl ~ 18! 215 0.96 0.94 ( 0.82 0.96 0.94 SMALL CELL CARCINOMA NE,, $tAVu10 55 1189 1.00 ~ 1.00 1.00 1.00 ~ 1.00 10<S1AV<.18 1 83 0.20 ( 0.03• 1•48) 0.21 ( 0.03- 1.62) 0.23 ( 0.03- 1.77) 0.20 ( 0.03- 1.48) 0.20 ( 0.03- 1.54) 18<$1AV 2 55 0•53 f. 0.12- 2•38) 0.53 ( 0.12- 2.37) 0.72 ( 0.15- 3.37) 0.52 ( 0.12- ~ 2.34) 0.56 ( 0.12- 2•59) Exc2udrd/Trend ~ 12 315 0.13 0.13 0.15 ~ 0.13 1 0,72 ADENOCARCINOMA NE., S1AV<.10 $66 19<S1AV<.18 13 78<S'IAV 21 1108 1.00 1.00 1.00 ' 1.00 1.00 83 0.50 ( 0.27. 0.93) 0.46 ( 0.24• 0.90) 0.40 ( 0.19- 0.88) 0.51 ( 0.27- 0.94) 0.45 ( 0.23- 0.89) SS 1.40 ( 0.81- 2.42) 1.37 ( 0.78- 2.43) 1.67 ( 0.88- 3.19) 1.42 ( 0.82- 2.46) 1.26 ( 0.68- 2.36) €xcltJdrd/Trlnd 33 215 0.94 0.94 0.96 0.95 0.94 OTHER NE., S1AV<10 10<31AV<•18 iR<$1AV ~ 86 7189 1.00 1.00 1.00 7.00 7.00 ( 6 831 0.74 (, 0.31- 1.80) 0.81 ( 0.33- 1-98)1 0.83 ( 0.31• 2.22) 0.75 ( 0.31- 1.82) 0.85 ( 0.34- 2.t1)~ 5 ~ 55 1.13 ( 0•43• 2.98) 1.15 ( 0.43- 3.08) 0.88 ( 0.26- 3.05) 1.13 ( 0.43- 2,99) 1.46 { 0.54- 3.96) :xcludrd/Trendl 18 1 2151 0.87 0.84 ~ 0.84 1 0.86 0.87 1 >75% OF LIFESPAN IN RURAL AREA OR INTERMEDIATE CITIES NE,. S1AV<10 190 398 1.00 1.00 1.00 10<S1AV<.18 10 27 0.57 ( 0.26- 1.27) 0.57 ( 0.26- 1.27) 0.61 ( 0.26• 1.47) 18<SIAV 151 18 1.64 ( 0.77• 3.50) 1.64 ( 0.77- 3•50) 2.14 ( 0.79- 5.75) Excluded/Trend 411 1311 0.65 0.65 i 0.52 >75% OF LIFESPAN IN URBAI AREA NE., 51AV<.10 192 571 1.00 1.00 j 1.00 1o<S1AV<.18 8 42 0.44 ( 0.20- 0•98) 0.98) 0.44 ( 0.20- 0.96)'t 0.38 ( 0.15- 0.96)1 18<S1AV 15 31 1•31 0.66- 2.60) 1.31 ( 0.66- 2-60)~ 1.31 ( 0.61- 2.84) Excludod/Trrnd 29 67 0.78 0.78 ) 0.78 ~ (1) Model Include sex, ceneer, sex'center and age (2) Madel irtdude sex, canler, sex'aKtler, age and proportion of residenGal type In the last 35 yrs (REUP) (3) Model Indudo sex, center, sex•cenler, age, praportion of residenlia) type in the last 35 yrs (REUP) and educational Ievel (EDUC) (4) Model Include s". center, sex•cenler. age and duration of exposure to lst A a9ents (OCLAY) (5) Mode! Indude sex, center, sex center, age and trequency consumplion of vegetables (VEGE) 1XV 1.00 0.58 ( 1.71 ( 0.66 0.26• 0.80• 1.29) 3.64) 1 1•00 0.54 ( 1.35 ( 0.64 0.24- 1-20)/ 0.58- 3.15) l) ~ 1-00 1.00 0.43 ( 0.19- 0.96) 0.46 ( 0.19- 1.11) 1.29 ( 0.65- 2.55) 1.32 ( 0.60- 2.93) 0.75 0.78 27'063593377 - - Risk estimates - Spouse

2.3.5 Workplace Risk estimates

Risk estimates - Spouse and other cohabitants linrA

WOTS Workplace, Ume since last ETS exposure (years) ITALY 2 Total Exposed Unrxnosed Exduded I Min [ P10 01 [ Median 03 P90 [ Max [ Mean E Std Mcn C3sOs 3 2 1 0 0.00 0.00 0.00 7.50 15.00 15.00 15.00 7.50 10.61 COntf0ls 97 55 42 0 0.00 0.00 0.00 5.00 13.00 19.00 54.00 8.15~ 10.23 AN 100 57 43 0 0.00 0.00 0.00 5.00 13.00 19.00[ 54.00 8.12 10.15 WOrt1Gn CeSCf 18 7 9 0 13.00 13.00 16.00 22.00 36.00 43.00 43.00I 24.29 11.131 COnlt0lf ~ ?8 18 68 0 0.00~ 0.00 0.00 9.00 42.00 47.00 48.00! 18.00 19.291 AN ~ 32 25 67 0 0.00[ 0.00 4.00 16.00~ 36.00! 43.00 48.00f 19.76 17.401 All CBSh 19: 9 10 0 0.00 0.00 95.00 17.00 23.00 43.00 43.001 20.56 12.72 COnU01i 173 73 100 0 0.00 0.00 0.00 5.00 14.00 32.00 54.00 10.58 13.59 At/ 192 82 110 0 0.00 0.00 0.00 6.50[ 16.00[ 35.00 54.00 11.67 13.78 rrA1.Y 3 MCt1 C~SQS 1 0 1 0 € COnU01f 12 4 8 0 0.00 0.00 0.00 0.00 2.50 5.00 5.00 1.25 2.50 AA 13 4 9 0 0.00 0.00 0.00 0.00 2.50 5.00~ 5.00 1.25 2.50 WOtif6n C85C5 15 1 ~ 14 0 17.00 17.00 17.00 17.00 17.00 /7.00 17.00 17.00 0.00 t COntrols ~ 38 11 27 0 0.00 0.00 0.00~ 0.00 12.00 14.00 28.00 5.55 9.03 All 53 12I 41 0 0.00 0.00i 0.00 1.00 '3.00 17.00 28.00 6.50 9.22 Au G1sa 16 1 15 0 17.00 17.0o T7.oo 17.00 17.00 17.001 17.00 17.00 0.00 ~f 51 35 ~ 00 28.00 4.40 7.96 At1 66 16 50 0 0.00 0.001 0.00 0.00 8.00~ 57.00j 28.00 5.19 8.31 Men Cases 18 13 3 0 0.00 0.00 1.00 4.00 7.00 38.00 40.00 8.77 13.69 Controls 8 5 3 0 0.00 0.00 0.00 0.00 0.00 5.00 5.00 1.00 2.24 A11 24 18 6 0 0.00 0.00 0.00 2.50 6.00 38.00 40.00 6.61 12.09 WOn180 Cases 33 17 16 0 0.00 0.00 0.00 0.00 0.00~ 7.00 26.00 2.53 6.46 Controls 31 10 21 0 0.00 0.00 0.001 0,50 9.00 10.00 10.00 3.50 4.53 AN 64 27 37 0 0.00 0.00 O.oOi 0.00 5.00 10.00 26.00 2.89 5.75 Afl CaSes 49 30 19 0 0.00 0,00 0.00 0.00 6.00 17.00 40.00 5.23 10.51! Controls 39 15 24~ 0 0.00 0.00 0.00 0.00 5.00 10.00 10.00 2.67 4.011 All 88 45 43 0 0.00 0.00 1 0.00 0.00 5.00 10.00 40.00 4.38 8.91 PORTUGAL2 MCn Cases 10 3 7 0 0.00 0.00 0.00 1.00 6.00 6.00 6.00 2.33 3.21 I Controls 17 7 10 0~ 0.00 0.00[ 0.00 0.00 10.00 19.00 19.00 5.14 7.36 i All 27 10 17 0 0.00 0.00 0.00 0.50 7.00 14.50 19.00 4.30 6.34 WOn1Gn CESCS 23 16 0 0.00 0.00 0.00 8.00 16.00 37.00 37.00 10.57 13.39 Controls 36 7 29 0 0.00 0.00 0.00 0.00 17.00 24.00 24.00 5.86 10.20 AN 59 14 45 0 0.001 0.00 0.00 0.00 16.00 24.00[ 37.00 8.21 11.70 All Cis9s 33 10 23 0 0.00 0.00 0.00 3.50 13.00 26.50 37.00 8.10 11.73 COnUOis 53 14 39 0 0,00 0.00 0.00 0.00 10.00 1 19.00 24.00 5.50 8.55 AN 86 24 62 0 0.00 0.00 0.00 0.00 11.50 19.00 37.00 6.58 9.85 SPAIN Men Cases 6 6 0 0 0.00 0.00 0.00 13.50 17.00 31.00 31.00 12.50! 11.84 Controls 13 10 3! Oi 0.00 0.00 0.00 10.50 1 19.00 31.50 44.00 12.50[ 13.57 AU 19 16 31 0 0.00 0.00 0.00 10.50 18.50 31.00 44.00 12.50 12.54 WomCn C9s®f 65 33 32 01 0.00 0.00 4.00 16.00 37.00[ 42.00 52.00 19.67 16.98 Controls 146 64[ 81 1~ 0.00 0.00 2.00 17.50 34.00 42.00 50.00 19.06~ 16.64 AN 211 97 113 1 0.00 0.00 2.00 16.00 35.00 42.00 52.00 19.27 16.67 AlI CSsCs 71 39 321 0 0.00 0.00 2.00 16.00 37.00 42.00 52.00 18.56 16.37 Controls 159 74 841 1 0.00 0.00 2.00 15.00~ 34.00 42.00 50.00 18.18 16.33 All 230 113 116 1 0.00 0.00 2.00 16.00 34.00 42.00 52.00 18.31 16.27 Men CBsQf 23 211 2 0 0.00 0.00 2.00 8.00 17.00 25.00 36.00 10.90 10.53 j ContrOaf 36 32! 4! 0 0.00 1.00 2.00 7.00 ~ 17.00 27.00 ~ ~ 44.00€' 11.16 11.8 7 I All _ 52 53 6 0 0.00 0.00 2.00 7.00 !! 17.00 27.00[ ' ' 44.001 11.06 11.25 Women CBsOs 47 41 6 0! 0.00 0.00 0.00 6.00 14.00 24.00 37.00 9.17 10.09 Controls 76 59[ 17 01 0.00 0.00 5.00 11.00 24.00 35.00[ 50.00 15.22 13.57 AIl 123 100 23 0 0.00 0.00 1.00 9.50 22.00 30.501 1 50.00 12.74 12.57 All CeSCf Ccntrols All 70 112 182 62 8 0 0.00~ 91! 21f€ 0 0.00 153 291 0 0.00 0.00 0.00 0.00 0.00I 3.001i 2.00 6.50 9.00 9.00 16.00 23.00 20.00 25.00[ 33.00[ 29.00[ 37.00 9.761 10.19 50.00 13.79 13.08 50.00 12.16[ 12.12 Men CSsCf 3 3 0! 0 0.00 0.00 0.00 11.00 19.00 19.00 19.00 10.00 9.54 COnUois ~ 14 13 'I 0 0.00 0.00 5.00 9.00 15.00 31.001 46.00 12.54 13.26 All _ 17 16 .._~__ _. _.. 0 0.00~ 0.00 3.50 9.50 17.00 31.00! 46.00 ~ 12.06 12.40 WCmOn G9sCf 23 10 0 0.00 0.50 4.00 12.00 30.00 41.00 51.00 17.90 16.49 Controas 1261 65 61 0 0.00~ 0.00 9.00 28.00 43.00 49.001 57.00 26.48N 18.11 All 149 75 7.4~ 0 0.00! 0.00 9.00 27.00 42.00 49,001 57.00 25.33[ 18.04 A~/ C85Cf 26 13 1°3~0 0.00 0.00' 4.00 12.00 28.00 31.00 51.00 16.08 15.20 Controls 140 ~ 78 82'E 0 0.00 0.00 8.00 24.00 ~ 41.00 49.00 57.00 24.15 18.10 AN 166 91 751 0 0,00 0.00 6.00 21.00 41.00 48.00 57.00 23.00 17.86 2063593406

S1TS Spouse, Time since last ETS exposure (years) 1TALY 2 Total ~ Fxeoscd Unexposed Exduded Min P10 €71 Median 03 j P90 ~ Max Mean Std Mef1 CaSe3 3 0 3 0 . I Controls 97 16 82 0 0.00 0.00 0.00 0.00 4.00 15.00~ 21.00 3.331 6.63 AN 100 15 85 0 0.00 0.00 0.00 0.00 4.00 15.00~ 21.00 3.331 6.63 Wontat CaSCS 16 3 7 1 0.00 0.00 4.50 10.50 14.00 29.00 29.00 10.88 9.22 Controls 76 491 24 3 0.00 0.00 2.00 9.00f 16.00 28.00 45.00 11.35 11.19 AN 92 571 31 4 0.00 0.00 '[.00 9.00. 16.00 28.00 45.00 11.28 10.86 AI C83et 19 8 10 1 0.00 0.00 4.50 10.50 14.00 29.00[ 29.00 10.88 9.22 Corltroli 173 64 106 3 0.00 0.00 0.00 ~ 5.50 15.00 24.00~ 45.00 9.47 10.81 AN 192 72 116 4 0.00 0.00 0.00 7.00 15.00 24.00! 45.00 9.63 10.60 rrALY 3 MCn CaSCs 1 1 0 0 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 Controls 12 2 10 0 0.00 0.00 0.00 1.00 2.00~ 2.00 2.00 ~ 1.00 1.41 A8 13 3 10 0 0.00 0.00 0.00 0.00 2.00 2.00 2.00 0.67 1.15 WOnkrl Cases 16 10 4 1 0.00 0.00 2.00 6.50 13.00 26.50 32.00 9.60 10.15I COntrolf 381 24 13 1 0.00 0.00 0.00 4.00 ~ 13.50 21.00 40.00 7.63 10.06 A11 531 341 17 2 0.00 0.00 0.00 4.50 13.00 . 21.00i 40.00 "c.21 9.97 Atl Cases i6 11 4 1 0.00 0.00 0.00 6.00 13.00I 21.00 32.00 8.73 10.05 Controls 60 26 23 1 0.00 0.00 0.00 3.00 13.00, 21.00 40.00 ~ 7.12 9.82 AU BB 37 27 2 0.00 0.00 0.00 4.00 93.00 21.00 40.00 7.59 9.78 Men CSse3 16 3 13 0 0.00 0.00 0.00 0.00 21.00 21.00 21.00 7.00 12.12 Controls 8 0 a 0 All _ 24 3 21 0 0.00 0.00 0.000.00 21.00` 21.00s 21.00 7.00 12.12 Women Cr1SCb 33 17 16 0 0.00 0.00 0.00 0.00~ 2.00 12.00 25.00 3.65 6.95 Controli 31 14 17 0 0.00 0.00 0.00 0.00~ 20.00 22.00 30.00 7.43 10.94 AIl 64 31 33 0 0.00 0.001 0.001 0.00 11.00 20.00 30.00 5.36 9.01 A1I CSSef 49 20 29 0 0.00 0.00 0.00 0.00 6.00 16.50 25.00 4.15 7.59 Controls 39 14 25 0 0.00 0.00 0.00 0.00' 20.00~ 22 00 30.00 7.43~ 10.94 AN 08 34 54 0 0.00 0.00 0.00 0.00~ 11.001 21.00 30.001 5.50 9.11 Men CasoS 10 0 10 0 l;:T Controls 17 0 17 0 ~ AN 27 0 27 0~ t - ~ WOmM C8584 23 16 6 1 0.00 0.00 1.50 5.00 17.00 31.00 46.00 11.63 13.21 Controls 36 15 't1 0 0.00 0.00 8.00 19.00 28.00 32.00 45.00 17.93 13.08 All 1 59 31 27~ 1 0.00 0.00 3.00 14.00 24.00 31.00 46.00 14.68 13.32 AII CSSeS 33 161 ~ 6 1 0.00 0.00 1.50 5.00 17.00 31.00 46.00) 11.63 13.21 ~ Controls 53 15~ 38 0 0.00I 0.00` 8.00 . 19.00~ 28.00' 32.00 45.001 17.93 13.08I All 86 31 54 1 0.00 0.00 3.00 14.00~ 24.00~ 31.00 46.001 14.68 13.32 SPAIN MCrt ~ Cases Controls AN 8 13 19~ 1 0 1 5 13{I 181 0 0 0 0.00 1 0.001 0.00 0.00 0.00 € 0.00 0.00 0.00 0.00 0.00 0.00I 0.00 I 0.00~ 0.00 0.00 0.00 0.00 E 0.00 WomCn Ci303 65 34 18 13 0.00 0.00 1,.00 9.50 17.00 30.00 52.00 11.97 13.33 Conttol9 148 91 37 18 0.00 0.00 0.00I 3.00 11.00 23.00 46.00 7.67 10.50 AN 211 125 55 31 0.00 0.00 0.00 4.00 13.00 27.00 52.00 8.84 11.44 All C95e8 71 35 23 i3 0.00 0.00 1.00 9.00 17.00 30.00 52.00 11.63 13.29 ~ Controls 159 91 50 18 0.00 0.00 0.00 3.00I 11.00 23.00 46.00 1 7.67 ::: 10.50 Ah 230 126 73 31 0.00 0.00 0.00 4.00 13.001 27.00 52.00 8.77 11.43 SWEDEN MCn C7SQS !, 23 8 15 0 0.00 0.00 0.00 1.501 24.00 41.00 41.00 11.50 16.19 f COnlro~3 36 9 7 0 0.00 0.001 3.001 11.001 25.00 37.00 37.00 14.78 13.26 AN~ 59 17 42 0 0.00 0.00 0.001 8.00 25.00 37.00 41.00 13.241 14.33 WomQn Cases 47 24 23 0 0.00 2.00 7.50 1 8.501 25.00~ 35.00 44.00 17.54 12.56 r Controlf 76 41 35~ 0 0.00 0.00~ 3.00 14.00 ^<3.00 30.00 39.00 13.85 11.78 AN 123 65 58 0 0.00 1.00 5.00 14.00 23.00 32.00 44.00 i5.22 12.11 Atl CiSe3 70 Conlr0ls 112 AN 182 32 50 82 38, 0 62 0 100 0 0.00 0.00 0.00 0.00 2.50 16.50 25.00 0.00 3.00 13.50 23.00 0.00 3.00 14.00 25.00~ 35.001 31.00~ 32.00` 44.00 39.00 44.00 16.03 13.54 14.02 11.92~ 14.811 12.53, UNITED KINGDOM Men CasCB 3 1 2 0 3.00 3.00 3.00 3.00 3.00 3.00 3.00 3.00 0.00 Control9 14 3 11 0! 0.00 0.00 1 0.00! 0.00 0.00 0.00 0.00 0.00 0.00 A11 17 4 13 0 0.00 0.00 0.001 0.00 1.50 3.00 s.00i 0.75 1 .50 Women C3SC3 23 17 5 0 0.00 0.00 1.001 11.001 25.00 44.00 48.00 15.41 15.95 Controls 126 77 49 0` 0.00 0.00I 4.001 11.00 23.00 33.00 45.00~ 14.04 12.10 ~ Ati 149 94 55 0 0.00 0.001 ~ 3.00 11.00 23.00 33.00 1 48.001 14.29 12.79 AU CSSeS 26 18 8 0 0.00 0.00 1.00 11.001 25.00 44.00 48.00 14.72 15.74 Controls 140 80 60 0 0.00 ~ 0.00 3.001 10.50 22.50 31.50 45.00 13.51 12.16 All 106 98 68 0 0.00 0.00 3.001 11.00 23.00 33.00 48.00 13.73 12.81

2,3,4 Spouse and other cohabitants Descriptive statistics of quantitative variables

S1 CS Spouse, Cumulative exposune of smoking spouse (packs/day x years) MEN ONLY Totat Ex6osed jUn sLd Excluded I Min ( P10 ~ 01 Median 03 P90 / Max Mean Std ; MM1 C~SE7 i15 18 97I 0 0.25 1.00 3.20 9.13 18.00! 30.00 33.00 11.71 10.18 Controls 487 ~ 59 426 f 2 0.25 1.25 2.40 6.00 ~ 19.00f 30.00 48.00 1 11.43 11.811 All € 737 1 , 77 I 523. 137 0.25 1 1.00 2.50 6.50 18.0030.00 48.00 1 11.49 11.391 WCrt1Gt1 CESCf 0 0 0 0 E Controls 0 0 0 0 ~ I Alt 0 0 0 0 AI CmsC9 157 18 97 42 0.25 1.00 3.20 9.13 18.00 30.00 33.00 11.71 10.181 Controls 580 69 426 95 0.25 1.25 2.40 6.00 19.00 30.00 48.00 11.43 11.81 I A11 737 ,77 523 137 0.25 1.00 2.50 6.50 18.00 30.00 48.00 11.49 11.39 WOMEN ONLY Ma1 Cases 0 0 0 0 ! =~ ~63593~ 12 ~ Controls 0I 0 0 0 ~ All Of 0 0 0 F WOn10n C95C9 393 201 155 37 0.10 2.80 9.60 23.001 38.20 62.50 135.00 27.76 23.85i COi1VOlb 814 460 311 43 0.15 2.90 7.68 21.00 36.63 54.00 336.00 26.15 26.11 ~ All 1628 661 466 499 0.10 2.80 8.50 21.50 37.50 56.00 336.00 26.64 25.44 AH CeSC9 550 201 155 194 0.10 2.80 9.60 23.00 38.20 62.50 135.00 27.76 23.851 COntrds 1076 460 311 305 0.15 2.90 7.68 21.00 36.63 54.00 336.00 26.15 26.11! AII 1826 661 466 499 0.10 2.80 8.50 21.50 37.50 56.00 336.00 26.64 25.441 POPULATION ®ASED STUDIES Men Cases 32 Controls All 365 535 12 54 6"6 40 310 350 0 1 119 0.25 0.25 0.25 1.00 1.25 1.00 1.50 2.40 2.00 10.50 6.75 7.63 19.351 19.00 19.00 23.25 33.00 30.00 48.00 30.00 48.00 11.64 12.18 12.08 10.661 12.07 11.751 Women Cases 153 76 58 19 0.75 3.50 10.00 23.40 36.00 62.00 135.00 27.43 24.14 Controls 370 222 134 14 0.15 3.00 7.50 19.00 33.00 55.10 336.00 25.18 1 28.85 A11 793 298 192 303 0.15 3.00 3.40 19.90 34.00 58.00 336.00 25.75 27.701 AII Cases 37B 88 98 192 0.25 2.20 8.10 18.38 33.80 60.00i 135.00 25.28 23.381 . Controls 950 276 444 230 0.15 2.00 6.00 17.33 30.25 51.75i 336.00 ~ ~ 22.64 26.901 All 1328 364 642 422 0.15 2.00 6.00 18.00 32.00 51.75 336.00 23.281 26.09~ h1Cf1 CaSf3 47 6 41 0 3.20 3.20 4.65 8.13 17.00 30.00 30.00 11.85 10.10( CO~1troIS 73 6 68 0 1.80 1.80 2.50 2.80 3.25~ 6.00 6.00 3.27 1.611 AII 120 11 109 0 1.80 2.50 2.80 4.651 8.25f ?7.00/ 30.00 7.95 8.491 WOrt1Cl1 CasCT 192 112 69 18 0.10 2.00 9.80 24.50 41.95 66.00 103.50 29.63 24.35/ Controls 379 218 133 28 0.15 3.00 9.30 23.95 40.00 52.50 132.00 27.40 22.421 All 578 330 202 46 0.10 2.48 9.50 24.00 40.50 57.00 132.00 28.16 23.081 All Casas / 246 118 110 18 0.10 2.00 8.50 23.20 40.10 66.00 103.50 28.72 24.131 COntrOlL ~ 452 223 201 28 0.15 2.70 8.10 23.35 40.00 52.00 132.00 26.86 22.46, A1l 698 341 311 46 0.10 2.50 8.50 23.35 40.00 56.00 132.00 27.51 23.031 WITHOUT OCCASIONAL SMOKERS Men Cases 72 12 60 0 0.25 1.00 3.35 8.13 77.50 20.70 30.00 90.38 9.18 1 Controls 330 41 288 1 r 0.25 1.70 3.20 10.00 21.50 30.00j 48.00 13.50 12.021 All 518 83 348 1171 0.25 1.60 3.20 9.60 19.00 30.00 48.00 12.80 11.43i WOfnOn C3SC4 290 147 116 27 0.10 2.50 9.60 23.00 37.00 62.00 135.00 _7.33 23.91; Controls 618 338 239 41 0.15 2.70 3.50 21.00 38.501 57.00 336.00 27.32 28.181 ~ r All 1240 485 355 400 0.10 2.70 8.90 21.601 38.00 58.50 336.00 26.93! 27.32 AI1 CiSCS 542 159 176 207 0.10 2.00 8.50 27.OD 36.75 62.00 135,00 26.05 23.54; Controls 1216 379 527 310 0.15 2.25 7.50 19.80 37.00 55.10 336.00 25.821 27.24, All 1763 I 538 703 517 1 0.10 2.25 7.50 20.80 36.75 55.50 336.00~ 25.89 26.18 Men Cases 42 6 36 0 0.25 0.25 8.25 16.50 18.00 20.70 20.70 13.37 7.661 Controls 145 22 122 1 1.00 2.00 2.80 6.00 12.50 1 22.50 27.00 9.08 7.92i All ~ 229 28~ 158 43 0.25 1.70 2.85 7.63 16.50 22.50 27.00 9.99 7.93! WOm~1 Ga9C3 110 52 55 3 0.15 2.20 4.80 12.00 27.75 43.05 74.00 17.87 16.98 Controls 229 `:18 105 6 0.15 1.70 6.00 16.05 28.00 42.75 78.00 ~ 19.78 16.53, AII 392 1701 1601 62 0.15 1.73 5.75 15.00 28.00 42.90~ 78.00 19.20 16.64 At1 3CS C9 195 56 91 46 0.15 0.80 5.001 12.25 25.00 43.05 74.00 17.40 16.28 Controls 426 140 227 59~ 0.15 `:.73 5.75 15.00 26.38 39.50 78.00 18.10 15.96 A1f 621 198 318 105~ 0.15 1.70 5.50 14.00 26.00 40.00 78.00 17.90 16.01 Men Cases 33 6 27 0~ 1.00 1.00 3.20 9.00 23.25 33.00 33.00 13.08 12.48 Controls 175 17 158 0 0.90 1.25 2.00 6.50 19.00 27.75 48.00 12.26 ?3.02 All 268 23 185 60 0.901.25 2.00 8.00 23.25 27.75 48.00 12.47 12.60 WOrt1Cr1 Cases 114 63 39 12/ 1:.00 5.00 12.75 28.90 40.10 70.00 99.00 31.34 23.43 Controls 252 144 92 16 0.40~ 3.00 8.25~ =2.00 33.75 50.00 117.00 24.42 20.08 All 535 207 131 197 0.40 3.00 9.90 24.00 35.00 56.00 117.00 26.53 21.34 All Cases 226 69 68 93 1.00/ 3.20 11.80 27.75 37.80 1 70.00 99.00I 29.75 23.21 Controls ~ 575 161 250 164 0.40, 2.15 7.50 19.00! 33.00 50.00 117.00~ 23.14 19.79 All 803 230 316 257 0.40 2.38 8.10 22.00/ 34.90 52.25 117.00 25.12 21.04 AGE G5t YEARS Men Cases 40 8 34 0 1.00 1.00 2.00 4.08 11.00 30.00 30.00 8.69 11.01 COnV015 167 20 146 1 0.25~ 0.55 1.70) 5.50 25.75 37.00 40,00 13.31 14.25 All 240 26 180 34 0.25) 0.80 1.80 4.83 21.50 35.00 40.00 12.24 13.51 WOn1Qn CSs©S 169 86 61 22 0.10 2.00 10.50 25.64 43.50 66.20 135.00 31.11 26.16 COnIrOls 333 198 114 21 0.15 3.60 10.00 22.65 44.00 63.00 336.00 31.20 32.88 All 699284 175 240 0.10 3.00 10.10 23.90 43.95 64.00 336.00 31.17 30.95 All Cases ~ ntrols 284 92 9391 310 95 355 97 274 0.10 0.10 2.00 2.?0 8.60 8.50 24.85 22.50 43.00 42.30 '6.00 82.00 135.00 336.00 29.64 29.59 26.02 1 30.33 '

S1CU Spouse, Cumulative exposure (packs/day x years) HISTOLOGICALLY CONF1RMEb DIAGNOSIS Total Exposcd Unexpcsed Exduded Min P10 j 01 f Median 03 ~ P90 ~ Max I Mean j 3to E Mcn CitQf 149 22 127 0 0.10 0.30 0.84 3.35 7.76 10.50 14.23 4.67 4.30 Controls 566 58~ 499 9 0.03 0.40 i.01 2.50 7.86 10.95 21.43 .75 5.09 Al 732 80 626 26 0.03 0.34 1.00 2.81 7.81 10.87 21.43 4.73 4.86 Women CaSCS 513 248 205 60 0.01 0.55 2.34 7.13 14.75 29.86 93.29 11.97 14.82 Controls 950 510 371 69 0.01 0.90 2.85 7.00 14.00 25.30 68.14 10.75 11.71 AH 1607 758 576 273 0.01 0.83 2.63 7.10 14.25 26.60 93.29 11.15 12.81 XI CSSCS 683 270 332 81 0.01 0.51 2.28 7.02 14.00, 27.77 93.29 11.38 14.40 Controls 1656 568 870 218 0.01 0.83 2.42 6.71 13.20 23.14 68.14 10.14 11.36 All 2339 836 1202 299 0.01 0.71 2.36 6.75 13.54~ 25.53 93.29 10.54 12.42 SCUAMOU$ CELL CARCINOMA Men C8SC3 28 1 27 0 7.50 7,50 e'.50 7.50 7.50 7.50 7.50 7.501 0.00 Controls 566 68 499 9 0.03 0.40 1.01 2.50 7.86 10.95 21.43 4.751 5.09 A!I 608 59 526 23 0.03 0.40 1.01 2.50 7.86 10.95 21.43 4.80 5.06 WOrt}Cn GSCf 91 44 35 12 0.10 0.54 1.19 8.66 16.82 23.79 68.00 11 45 5 13.66 Controlt 950 510 371 69 0.01 0.90 2.85 7.00 14.00 25.30 68.14 10.75 11.71 AH 1173 554 406 213 0.01 0.83 2.82 7.17 14.00 25.11 68.14 10.80 11.86 AII GSC9 125 45 62 18 0.10 0.54 1.23 8.06 16.00 23.79 68.00 11.36 13.52 Controls 1656 568 870 218 0.01 0.83 2.42 6.71 1L 3.20 23.14 68.14 10.14 11.36 All 1781 613 932 236 0.01 0.75 2.36 6.75 13.44 23.14 68.14 10.23 11.52 SMALL CELL CARCINOMA MCn C3fCt 13 2 11 0I 4.65 4.65 4.65 6.21 7.76 7.76 7.76 6.21 2.20 Controls j 566 58 499 9i 0.03 0.40 1.01 2.50 7.86 10.95 21.43 4.75 5.09 Al I 594 60 510 24 0.03 0,47 1,02 2.65 7.81 10.87 21.43 4.80 5.02 WommiCn CASCS 62 31 25 6 0.15 0.46 1.65 3.04 13.59 17.57 60.64 8.57 11.86 Controls 950 510 371 69 0.01 0.90 2.85 7.00 14.00 25.30 68.14~ 10.75 11.71 All 1143 541 396 206 0.01 0.90 2.70 6.90 14.00 25.00 68.14 10.62 11.72 Afl CHSCS 81 33 36 12 0.15 0.46 1.88 3.23 12.70 17.57 60.64 8.43 11.51 ! Controls 1656 568 870 218 0.01 0.83 2.42 6.71 13.20 23.14 68.14 10.141 11.36I All 1737 601 906 230 0.01 0.75 2.29 6.591 13.20 22.791 "8.14 10.04 11.36 ADENOCARCINOMA Men Cases ! 79 14 65 0 0.20 0.30 0.32 2.80 7.89 12.38 14.23 4.62 4.79 Controls EEE 566 58 499 9 0.03 0.40 1.01 2.50 7.86 10.95 21.43 4.75 5.09 AH 660 72 564 24 0.03 0.36 1.00 2.50 7.88I 10.95 21.43 4.72 5.00 Women CafCt 277 134 115 28 0.01 0.90 2.63 7.07 15.32 33.21 75.43 12.60 15.13 Coniro46 950 510 371 69! 0.01IE 0.90 2.85 7.00 14.00 25.30 68.14 10.75 11.71 AN 1357 644 486 227 0.01' 0.90 2.83 7.04 14.07 27.00 75.43 11.13 12.51 ~ Cases 361 148 1801 33 0.01 0.50 2.45~ 6.87 14.11 30.88 75.43 11.85 14.65 f Controls 1656 568 870 218 0.01 0.83 2.42~ 6.71 13.20 23.14, 68.14 10.14 ?1.36 A3) 2017 716 1050 251 0.01 0.75 2.42 6.73 13.50 25.80 75.43 10.49~ 12.12 OTHER MCn GSCf 29 5 24 0 0.10 0.10 0.96 3.20 3.50 10.50 10.50 3.65/ 4.09 Controls 566 58 499 9 1 0.03~ 0.40 1.011 2.501 7.86 10.95 21.43 4.75~ 5.09 A)t 610 63 523 24 0.03f 0.40 1.00 2.50 '.86 10.79 21.43 4.66 5.00 WomCn CiSCt 83 39 30 14 0.01 0.90 2.83 7.89 14.79 34.11 93.29 13.12 17.11 Controls 950 510 371 69 0.01 0.90 2.85 7.00 14.00 25.30 68.14 10.75 11.71 AIl 1162 549 401 21'< 0.01 0.90 2.85 7.20 14.00 25.71 93.29 10.92 12.16 Alt CaSCf 116 44 54 18 0.01 0.90 2.64 7.50 14.13 26.25 93.29 12,04 16.42 sContlolt 1656 568 870 218 0.01 0.83 2.42 6.71 13.20 23.14 "8.14 10.14 ~ 11.36 Al1 1772 612 924 236 0.01 0.83 2.44 '.75/ 13.32 23.79 93.29 10.27 11.78 >75% OF LIFESPAN IN RURAL AREA OR INTERMEDIATE CITIES MCn CSSCS 73 ti 67; 0 0.32 0.32 0.96 2.80 6.74 14.23 14.23I 4.64 5.21 E Controls 1 212 9 2001 3 0.90 0.90 1.25 2.81 6.75 21.43 21.431!!! 5.30 6.58 All 301 15 267 19. 0.32 0.90 1.00 2.81 6.751 14.23 21.4$ 5.04 5.87 WO(Mn CeSCt 220 107 92 21 0.01 0.54 2.00 7.00 15.32 29.25 75.43 1 12.36 15.90 Controls 361 184 160 171 0.01 0,83 2.32 6.46 12.41 21.60~ 64.001 9.58 10.34 All 699 291 252 1561 0.01 0.64 2.21 6.60 14.00 25.71 75.431 10.60 12.71 AI GSCS 313 113 159 41 0.01 0.54 2.00 6.68 14.63 27.86 75.43 11.95 15.60 ~ COnUOIf 687 193 360 134 0.01 0.90 2.25 6.43 ~ 12.18 21.43i 64.00 9.38 10.22 ! AA 1000 _ 306 519 175 0.01 0.64 2.03 6.46 13.75 25.50) 75.43 10.33f 12.52 >75Y. OF LIFESPAN IN URBAN AREA MCn C35C5 48 12 36 0 0.20 0.30 1.36 3.81 8.78 10.50 12.38 4.93 4.20 ` C:ontrolt ~ 257 36 216 5 0.13 0.39 0.97 ~ 2.45 8.26 13.65 19.29 4.97 5.27 All 305 46 252 5 0.13 0.36 0.97 3.00 8.26 12.38 19.29 4.96 4.98 WOmcn CmsCt 193 100 67 26 0.01 1.03 2.78 7.07 14.15 35.08 93.29 12.68 15.93 ~ I Controls I 4351 257 135 43 0.01 0.96 3.28 714.50 28.44 68.14 11.52 12.56 All ~ 6501 357 202 91 0.01 1.00 3.00 7.14~ 14.50 30.05 93.29~ 11.85 13.58 AfI CmSCf 244 112 103 29 0.01 0.93 2.63 7.02 13.10 33.21 93.29 11.85 15.30 ~ Controls 711 293 351 67 0.01 0.75 2.48 6.90 14.14 25.80 68.14 10.72. 12.10 AIl ; 955 405 454 96 0.01 0.83 2.55 6.94~ 13.65 27.95 93.29 11,03 13.05 2063593396

C _S9 TS Spouse, Time since last ETS exposure (years) ALL CENTERS Levai of expozuro Caaes Controls OR(1) 95•. CI OR(2) 95% CI ? OR(3) 95% CI ~ OR(4) 95% CI ~ OR(S) 95% CI E Non expOSetl 305 838 1•00 , 1.00 1.00 1.00 1.00 154 S1TS 106 208 1.13 ( 0.84- 1.53)1 1.19 ( 0.87- 1.64) 1.18 ( 0.81- 1.71) 1.15 ( 0.85- 1.56) 1.22 ( 0.87- 1.70) 2< S1TS<15 111 241 1.16 ( 0.87- 1.55)j 1.13 ( 0.83• 1.54) 1.05 ( 0.74- 1.49) 1.16 ( 0.86- 1.56) 1.07 ( 0.77- 1.49) 0<.5173<.2 109 232 1.10 ( 0.82- i.47)I1.05 ( 0.77- 1.45) 1.03 ( 0.72- 1.47) 1.13 ( 0.84- 1.53) 1.05 ( 0.75- 1.47) c`XC1Udtd/Trond 19 23 0.02 ! 0.02 0.04 0.03 0.02 ALL CENTERS WiTH EDUCATIONAL LEVEL AND TYPE OF RESIDENCE Non expos.a 1s7 620 1.00 1.00 1.0o t.oo 1.00 1a< S1TS 74 150 1.21 ( 0.84- 1.75) 1.21 ( 0.84- 1.75) 1.18 l, 0.81- 1.71)~ 1.23 ( 0.85- 1.79)f 1.27 { 0.85- 1.89) 2< S1TS<.16 79 190 1.09 ( 0.77- 1.55) 1.10 ( 0.78. 1.56) 1.05 ( 0.74- 1.49)1 1.07 ( 0.75- i.53)1 1.14 ( 0.78- 1.67) 0<.S17S<.2 74 179 1.05 ( 0.73- 5.50)' 1.05 ( 0.74- 1.50) ~ 1.03 ( 0.72- 5.47)1 1.07 ( 0.75- 1.53)1 1.09 ( 0.74- 1.60) EXClua'td/Trtnd~ 84 199 0.12 ! 0.12 0.18 l~ 0.13 ~ 0.11 ALL CENTERS WITH DIETARY DATA Non axpoaed 231 534 1.00 1.00 1.00 ~ 1.00 1 1.00 S1TS 154 91 153 1.21 1 0.87- 1.69) 1.24 ( 0.88- 1.75) 1.21 ( 0.81- 1.81) 1.23 ( 0.88- 1•72) 1.22 ( 0.87• 1.70) 2< SiTSe,16 84 172 1.07 ( 0.77- 1.49) 1.09 ( 0.78. 1.54) 1.07 ( 0.73- 1.57) 1.03 ( 0.74- 1.44) 1.07 ( 0.77- 1.49) 0< S 1TS <2 S1TS<2 ~ 81 158 1.06 ( 0.76- 1.49) 1.07 ( 0.75- 1.51) 1.08 ( 0.73- 1.59) 1.11 ( 0.79- 1.56) 1 1.05 ( 0.75- 1.47) fxcl udad/Trand ! 22 39 0.11 0.11 0.17 i 0.13 0.10 FRANCE Non exposod 1a< S1TS 2< S1TS<15 0<S1TS<2 Excludtd/Trand 39 65 1.00 1.00 t 1.00 1.00 1.00 95 35 0.79 ( 0.36- 1.71) 0.66 ( 0.28- 1.58) 0•66 ( 0.21- 2.04) 0•78 ( 0.36- 1•71) 0.76 ( 0.35- 1•67) 15 23 1.18 ( 0.52- 2.66) 0.93 ( 0.37- 2.32) 0.75 ( 0.22- 2.58) 1.10 ( 0.48- 2.51) 1.16 ( 0.51- 2.62) ~ ~ 28 0.49 ( 0.19- 1•21) 0.31 ( 0.10- 0.95) 0.42 ( 0.10- 1.76) 0.50 ( 0.20- 7.25)~ 0.48 ( 0.19- 1.19) ! 0 0 0.28 0.14 0.10 0.25 0.26 GERMANYI Non exp0aetl 34 153 1.00 1•00 1.00 1.00 1.00 15< SITS 17 24 1.66 ( 0.73- 3.79) 1•70 ( 0.68- 4.24)i 1.66 ( 0.66• 4.16) 1.77 ( 0.76• 4.11) 1.94 ( 0.83- 4.52 ) 2< SiTS<18 14 31 1.25 ( 0.56• 2.81) 1.54 ( 0.65- 3.65)1 1.49 ( 0.63- 3.55) 1.19 ( 0.52• 2.72) 1.36 ( 0.60- 3.08) 0<.S1TS<2 9 21 1.31 ( 0.51- 3.35) 1.32 ( 0.48• 3.63) 1•29 ( . 0-47- 3.56) 1.37 ( 0.53- 3.54) 1.35 { 0•52- 3.50) fxc2uded/Trenrl 2 0 0.10 0.17 ~ 0.21 0.15 0.17 G€RMANY2 Non exposOtl 15e SITS 2< $1TS<15 0<.S1TS<.2 66 96 1.00 1.00 1.00 1.00 1.00 23 23 0.98 ( 0.48- 2.03) 0.93 ( 0.45- 1.93) 0.88 ( 0.42- 1.85) 0.98 ( 0.47- 2.02) 0.94 (, 0.45- 1.95) 21 21 1.01 (. 0.48- 2.11) 0.97 ( 0.46- 2.04) 0.89 ( 0.42- 1.88) 1.01 l, 0.48- 2.10) 1.00 ( 0.48- 2.09) 32 f 21 1.51 ( 0.75• 3.04) 1.42 ( 0.70• 2.87) 1.34 ( 0.66- 2.74) 1.51 ( 0.75- 3.04) 1.50 ( 0.74- 3.03) E.rcludad/Trtnd o I 0 0.30 0.37 0.50 E 0.30 0.30 G€RMANY 3 Non axposed 15< SITS 2< S1TS<15 0<S1TS<2 Excluded/Trend i 221 35 1.00 1.00 1.0o t.oo t.ao 3 3 2.05 ( 0.31-13.43) 2.03 ( 0.30-13.77) 1.22 ( 0.17- 8.89) 1.93 ( 0.23-15.96) 1.74 ( 0.26•11.88) 2 9 0.37 ( 0.07- 2.03) 0.37 ( 0.07- 2.05) 0.23 ( 0.04- i.36) 0.48 ( ~ 0.09• 2.72) 0.36 ( 0.07- 2.01) 4 5 1.23 ( 0.27- 5.66) 1.20 ( 0.24• 6.02) 0.91 ( 0.16- 5.08)I 1.32 ( 0.28- 6.21) 1.03 ( 0.21- 4.95) 0 0 0.76 ~ 0.70 1 0.37 0.77 ~ 0.50 ITALY I Non oxposad 16( 123 1.00 1.00 1.00 € 1.00 [ 15< S1TS 28 1.09 ( 0.36• 3.28) 1.44 ( 0.46- 4.53) 1•38 ( 0.43- 4.39)1 1.45 ( 0.46- 4.60) 24 3175<ib E 10 34 1.21 ( 0.45- 3.27) 1.63 ( 0.56• 4.72) 1.23 ( 0.41- 3•68)I 1.75 ( 0.61- 5.01) 0<S1TS<2 ~ j ' 3 0.68 ( 0.22• 2.05) 0.88 ( 0.29- 2.71) 0.82 ( 0.26- 2.54) 0.75 ( 0.23- 2.46) fxcludtd/Trendf i 0.75 0.63 ~ 0.64 { 0.72 ~ ITALY 2 Non exposed to 108( 1.00 1.00 1•001.00 ta< S1TS 1 151 0.21 ( 0.02- 1•96) 0•09 ( 0.01- 1.33) ~ 0.16 ( 0.02- 1.73) 0.17 ( 0.01- 2.64) 24 S17S<15 S 25 0.68 (, 0.19- 2.46) 0.73 ( 0.19- 2.83) 0.79 ( 0.13- 4.65) 0.66 ( 0.19• 2.37 ) 0<S1TS<2 2 1 24 0.47 ( 0.09- 2.57) 0.36 ( 0.05- 2.86) 0.99 ( 0.08-13.10)~ 0.46 ( 0.09- 2.51) rXC1udtd/Trend 3 0.91 0.90 0.90 0.97 ITALY 3 Non exposed 15< 31T3 2< S1TS<15 0<S1TS<2 fxcludad/Trand 4 23 1.00 1.co 1.00 1.00 1.00 2 3 2.19 ( 0,22-22.08) 1.93 ( 0.18-20.12) 0.93 ( 0.07-12.33) 1.49 ( 0.12-17.96) 1.86 ( 0.76-21.28) 5 10 1.67 ( 0.31- 9.12) 1.36 ( 0.24- 7.86) 0.60 ( 0.09- 3.99) 1.69 ( 0.30- 9.41) 3.29 ( 0.40-26.93) 4 13 1.81 ( 0.32•10.12) 1.97 ( 0.30-12.80) 1.23 ( 0.14-11.07) 1.91 ( 0.33-11.16) 2.71 ( 0.40-18.17) 11 1 0.26 0.43 0.60 ~ 0.61 0.25 PORTUGALI Non eXp45Q0 " 9 25 1•OO E 1.00 15< SITS 2 4 0.46 ( 0.07- 3.06) ~ ~ 0.46 ( 0.07- 3.05) 2< S1TS<.15 3 1 3.80 ( 0.34•42.67) f ~ 3.74 ( 0•34-41.51 ) ~ I 0< .S17S<2 15 9 2.00 ( 0.68- 5.83) 1.92 ( 0.66- 5.60) I !!! Exc2uded/Trmd 0 0 0.17 ~ ' 0.17 E PORTUGAL2 on exposetl 9 6 38 1.00 1.00 1.00 154 S1TS 4 8 2.72 ( 0.53-13•98) 2.41 ( 0.42•14.04) ~ 2.13 ( 0.38-12.03) 24 S1TS<15 ~ 8 4 12.19 ( 2.05•72.61) 5.57 ( 0.78-39.64) 11.75 ( 2•01•68.55) 0<S1TS<2 4 3 6.92 ( 1.06-45.28) 4.29 t, 0.57-32.44) 6.20 ( 0.96-40.29) fxcluded/Trendl 1 0 0.00 ) 0.01 I 0.00 SPAIN Non exposed 23 So 1•00 1.00 1.00 1.00 1.00 15< S1TS 1 0 15 1.44 ( 0.52- 4,01) 1.82 ( 0.61- 5•49) 1.87 ( 0.61- 5.69) 1.40 ( 0.50- 3.95) 1.38 ( .49- 3.89) 0 2< S1TS<.15 1 4 I 32 1•06 ( 0.44- 2.52) 1.23 ( 0.49- 3.07)1 1.24 ( 0.48- 3.17) 1.07 ( 0•44- 2.56) 1.09 ( •45- 2•63) 0 0<S1TSe2 I 11 44 0.53 ( 0.22- 1.26) 0.53 ( 0.21- 1.31) 0.47 ( 0.18- 1.22) 0.56 ( 0.23- 1.38) 0.51 ( 0.21- 1.24) Excludad/Trand ! I /3 1B~ 0.50 0.61 I 0.63 1 0.50 0.26 1 SWEDEN Non oxposed 38 15< S1T3 1 16 2< SiTS<16 8 0<S1TS<2 , 9 Excludtd/Trendi 0 UNITED KINGDOM Non exposea 8 15< S1TS f 6 ~ 2< SiTS<1b 6 0<S1TS<2 6 ! Excluded/Trend 0 62 1.00 1.00 ~ 1.00 t.oo s 1 20 1.44 ( 0.64- 3.23) 1.42 ( 0.62- 3.22) 1 1.51 ( 0.67- 3.39) 1.49 ( 0.66- ".38) 19 0,77 ( 0.30• 2.00) 0.78 ( 0.30- 2.04) 1 0.73 ( 0.27- 1.93) 0.75 ( 0.28- 1.96) 11 1.33 ( ~ 0.48• 3.73) 1.31 ( 0.46- 3.70) 1.42 ( 0.51- 3.97) 1.44 ( 0.51- 4.09) 0 0.84 0.8 5 ~ 0.80 . 0.78 6o t.oo 1.00 1.00 1 . 00 1.00 30 1.63 l 0.49- 5.38) 1.64 1 0.49- 5.49) 1.52 ( 0.45- 5.17 ) 1.83 ( 0.54- 6.15) 1.72 ( 0.51- 5.75) 32 1 44 ( 0.44- 4.67) 1.44 ( 0.43- 4.82) 1.25 ( 0.36- 4.37) 0.98 ( 0.26- 3.68) 1.51 ( 0.46- 4.96) 18 2.64 ( 0.78- 8.89) 2.56 ( 0.74- 8•90) 2.49 ( 0.71- 8.67) 3.22 ( 0.93-71.16) 2.73 ( 0.80- 9.30) 1 0 0.16 0.16 0.21 0.14 C 0.14 (1) Model Indude sex, center, sex'ccnter and age (2) Model Include sex, center, sex'center, age and proportion of residential type in the last 35 yrs (REUP) `J) MOdO( tnc(t7dH 56x, GBft(Cf, SCx'GCn(er, ige, prCportiGn of re5idential type in the iast 35 yrs (REUP) and educat;onal ievei (EDUC) (4) Model indude sex, center, sex•center, age and duration of exposure to list A agents (OCLAY) _(5]_MOdGLindOdS3Cx, centC[-SC?LCCnter-aQC_and fre0uencv COnsumption of veqetables (VEGE) _ _ _` 2J63593382

2.3.5 Workplac Descriptive statistics of quantitative variables

s1CU Spouse, Cumulative exposure (packs/day x years) MEN QNLY Total f Ex ed Unexposed Exduded Min P10 01 Median I C3 ( P90 Max ` Mean Std Men Case3 154 22 132 0 0.10 0.30 0.84 3.35 7.76 10.50 14.23 4.67 4.30 Controls 566 58 499 9 0.03 0.401 1.01 2.50 7.86 10.95 21.43 4.75 5.09 A11 737 80 631 26 0.03 0.34 1.00 2.81f 7.81 10.87 21.43~ 4.73 4.86 WOn1M C3se4 0 0 0 0 ~ E Controls 0 0 0 0 ~ ~ All 0 0 0 0 All ases 157 22 132 3 0.10 0.30 0.841 3.35 7.76 10.50 14.23' 4.67 4.30 Contta5 580 58 499 23 0.03 0.40 1.01 2.50 7.86 10.95 27.43{ 4.75 ~ 5.09 Afl 737 80 631 26 0.03 0.34~ 1.00 2.81 7.81 10.87 21.43 4.73 4.861 WOMEN ONLY Men CasQS 0 0 0 0 2063593395 ( Controls 0 0 0 0 ~ ~ ~ f AH 0 0 0 D WOn1Cn C3sM 527 257 209 61 0.01 0.55 ' 2.36 7.13 14.71 30.17 93.29 12.07 14.96 Controlf 950 510 371 69 0.01f 0.90! 2.85f 7.00 14.00 25.30 68.14 10.75 11.71 A11 1626 767 580 279 0.01 0.75! 2.63 7.07 14.25 26.79 93.29 11.19 12.89 Afl C3sCs 550 257 209 84 0.01 0.55 2.36 7.13 14.71 30.17 93.29 12.07 14.96 Controls 1076 510 371 195 0.01 0.90 2.85 7.00~ 14.00~ 25.30 68.14 10.75 11.71 All 1626 767 580 279 0.01 0.75 2.63 7.07 ?4.25~ 26.79 93.29 11.79 72.89 POPULATION BASED STUDIES MCn CaSCa 91 16 75 0 7.20 0.30 0.58 3.35 8 . 78 72.3$! 14.23 4.85 4.75 Controls 444 54 383 0.03 0,54 1.01 2.65 8.01 10.95I 21.43 4.92 5.21 ) All 535 70 458 71 0.03 0.37 1.00 2.81 8.01 11.66 21.43 4.90 5.07 Won10n C8sC3 287 142 111 34 0.01 0.75 2.33 6.80 13 . 00 30.88 93.29 11.69 15.76 Controls 506 288I 194~ 24 0.01 0.75 2.87 6.42 12.13 23.14 67.00 f 9.90 11 .22 All 793 430 305 58 0.01 0.75 2.63 1 6.43 12.21 25.66 93.29 1 10.43 12.91 AU CiSCi 378 158 186 34 0.01 0.45 2.25 6.21 12.38 29.25~ 93.29 11.00 15.15 Controls 950 342 577 31 1 0.01 0.70 2.10 5.84~ Y1.25 21.21 67.00 9.03 10.64 All 1328 500 763 65 0.01 0.66 2.22 5.90i 11.57 22.821 93.29 9.65~ 12.27 HOSPITAL BASED STUDIES MM l.9aQf 47 6 41 0 0.10 0.10 1.89 3.93 7.50 7.891 7.89 4.21 3.09 Controls 73 4 68 0.13 0.13 0.77 1.95 4.25 6.00 6.00 2.51 2.52 All 120 10 109 1 0.10 0.12 '<.40 2.85 6.00 7.70 7.89 3.53 2.86 WofiOn Casas ! 199 102 70 ` 27 0.10 0.53) 3.34 8.36 19.67 30.17 75.43' 13.42 14.47 Conlraa 379 203 133 43 0.03 1.00 3.00 8.49 16.29 25.93 68.14~ ?1.87 11.94 A11 578 305 203 70 0.03 1 0.90 3.21 8.43~ 17.06 27.86 75.43 12.39 12.84 II A CeSf3 246 108 111 27 0.10 0.50 3.01 7.70 18.901 30.17 75.43 12.90 14.24, Contras 452 207 201 44 0.03 0.97 2.83 8.40 16.07) 25.93 68.14 11.69 11.89i All 698 315 312 71 0.03 0.83 2.83 6.25 16.71f 27.68 75.43 12.11~ 12.74 WITHOUT OCCASIONAL SMOKERS en CBSCS 110 COtltrofs ~ 397 All 518 16 94 41 351 57 445 0 5 16 0.10 0.03 0.03 0.20 0.70 0.30 0.58 1.29 1.03 3.35 7.63 10.50 12.38 3.49 8.57 13.65 21.43~ 3.49 8.01 12.3821.43 4.27 3.88. 5.721 5.60 5.31 5.18 Won1Cn Cases 419 195 170 54 0.01 0.90 2.54 7.14 15.32 33.21 93.29 12.35 15.50 Controls I 747 390 297 60~ 0.01 0.99 2 89 ?.55 14.63' 26.26~ 68.14 11 .301 12.05 All ! 1240 585 467 188 0.01 0.94 : I 2 80 7.32 14.63 27.68 93.29 11.651 13.29 AII Casef 542 211 264 67 0.01 0.64 2.36 7.04 14.00 29.25 93.29 11.74 15.08 Controls 1216 431 648 137 0.01 0.93 2.57 7.00 14.29 25.11 68.14 10.771 11.70 A!l 1758 642 912 I 204 0.01 0.90 2.55 ~ 7.02 14.25~ 25.93 93.29 11.09 12.91 MCn Casaa 56 7 47 01 0.32 0.32 1.89 4.13 7.89 12.38 12.38 5.35' 4.42' Conlr0lf 170 22 143 Sf 0.13 0.701 1.00 2.50 4.34 7.18 8.84 3.16 2.63 All 29 31 190 8 0.13 0.70 1.00 2.50 1 6.75 8.41 12.38 1 3.79 3.32 Wort1Cn CiSCS 138 61 69 8 0.01 0.50 1.23 3.49 7.50 14.30 49,31 7.09 10.25 Controls 254 124 119 11 0.01 0.64 2.47f 5.84 12.94 21.38 64.00 9.19 10.04 All 392 185 188 19 0 01 1 0 50 1 86I 5 30 11 96 21 00f 64 00 8 50 10 13 . . . - . . . . . . Al/ CisQS 195 70 116 9 0.01 0.44 1 .23 3.55 7.76 13.90 49.31 6.87 9.69 Controls 426 146 262 18 0.01 0.64 2.00 5.28 11.961 21.00~ 64.00 8.28 9.55 AH 621 216 378 27 0.01 0.55 1.60 4.501 10.06) 17.14 64.00 7.82, 9.59 AGE 55-64 YEARS MQn CasQs 52 ? 45 0 0.10 0.10 0,30 3.20 6.74 ?4.23 14.23 4.15 5.02 Controls 216 15 198 3 0.36 0.39 1.03 2.811 9.50~ 16.71 21.43 5.61 6.51 All 268 22 _ 243 3 0.10 0.36 0.96 2.91 7.50 i4.23 L21.43 5.14% 5.99 Women Cases 166 83 65 18 0.01 1.00 2.93 8.36 17.64 27.86 75.43 12.331 13.25 Controls 304 167 1121 25 0.02 0.83 2.80 6.43 12.60 21.36 61.29 9.71 10.95 All 535 250 177 108 0.01 0.83 2.83 7.06 14,00 25.30 75.43 10.58 11.80 AIt Cases I Contraa AU 228 575 803 90 182 272 110 28 310! 83 420 111 0.01 0.02 0.01 0.64 083 0..75 2.70 2.36 2.57 7.45 15.86 6.26 12.38 6.74 13.63 27.64 21.21 25.07 75.431 61.29 75.43 11.70~ 12 98 9.37 10.70 10.14 11.53 Men Cases 46 6 40 0 0.20 0.20 0.31 3.93 7.50 9.79 9.79 4.28 3.86 Controls 180 21 1581 11 0.03 0.40 1.40 2.40 8.57 13.65 19.29 5.81 5.70 Ap 240 27 198 151 0.03 0.20 1.01 3.20 8.57 13.65 19.29 5.47 5.32 WomQn CaSSf 223 113 75 35 0.10 0.65 3.23 8.25 17.63 37.53 93.29 14.56~ 17.52 Controls f 392 219 140 33 0.01 1.18 3.83 8.79 16.88 30.05 68.14 12.42 12.92 All 699 332 215 152 0.01 0.96 3.53 8.49 16.94 31.39 93.29 13.15 14.66 A!l Casea 284 119 115 501 0.10 0.50 3.15 8.06 16.13 37.53 93.29 14.05 17.23 Controls 655 240 298 117 0.01 0.98 3.02 8.27 16.04 28.76 68.14 11.84 12.59 All 939 359 413 167 0.01 0.90 1 3.15 ~ 8.19 16.07 30.53 93.29 12.57 ?4.31

S1CS Spouse, Cumulative exposure of smoking spouse (packs/day x years) 1TALY 2 7out E+tposcd Unexposed Exduded Min P10 ~ 01 Median Q3 P90 ! Max Mean Std ~ MCn CASG3 3 0 3 0 ContrWa 97 15 82 0 1.60 1.80 3.20 6.00 ~ 15.00 21.50% 26.00 9.23 7.46 Akl 100 15 85 0 1.60 1.80 3.20 6.OO f 75.00 27.50 26.00 9.23 7.461 WOnu~l Cases 16 8 7 1 2.00 2.00 11.35 15.60 51.50 84.00 84.00 30.36 29.98 Controls 76 48 24 4 1.00 2.25 7.50 19.75 32.00 54.00 85.00 23.63 ~ 19.94 AH 92 66 31 5 1.00 2.25 8.20 18.25 33.50 54.00 85.00 24.59 21.45 AA Cases 19 0 10 1 2.00 2.00 11.35 15.60 51.50 84.00 84.00~ 30.36 29.98 COntrOls 173 63 106 4 1.00 2.00 ~ 6.00 15.00 29.00 44.751 85.00'E 20.20 18.77 All 192 71 116 5 1.00 2.00 6.001 15.00 30.00 48.00 85.001 21.34 20.31 rTALY 3 Men Cases 1 1 0 0 8.25 8.25 8.25/ 8.25I 8.25 8.25 8.25 1 8. 25 0.00 ConUola 12 2 10 0 2.80 2.80 2.80! 3.03 ~ 3.25 3.25 3.25 3.03f 0.321 A11 13 3 10 0 2.80 2.80 2.80 3.25 8.25 8.25 8.25 4.77 3.03 Women Cases 15 10 4 1 9.60 10.05 28.50 18.00 49.00 62.25 62.50 20.10! 33.36 Contrds 30 19 13 ~ 6 1.00 7.60 ~ 29.00 20.00 ~ 39.00 55.50 62.00 ~ 30.83 15.831 All 83 29 17 7 1.00 9.60 ( 20.00 29.00 44.00 62.00 62.50 31.701 17.101 AN Cases 16 11 4 1 8.25 9.60 10.50 22.00 49.00 62.00 62.50 31.08 20.51 Controls ~ 50 21 23 6 1.00 3.25, 16.00 28.50 38.00 50.00 62.00 28.18 17.19 AN 66 32 27 7 1.00 7-.60 15.05 27.75 41.50f 55.50 62.50 29.18 18.12 PORTUGALI Men Cases 16 3 13 0 8.00 8.00 8.00 17.00 30.00 30.00 30.00 18.33 11,06 Controls d 0 8 0 E ~ All 24 3 21 0 8.00 8.00 8.00 17.00 30.00 30.00 30.00 18.33 11.06 Womsn Casaa 33 17 16 0 2.00 4.00 23.00/ 28.90 52.00 78.00 81.00 37.62 25.96 Controls 31 14 17 0 1.35 2.10 9.10i 12.35 27.30 36.25 52.00 17.66 14.32 Af! 641 31 33 0 1.35 4.00 10.50I 23.00 37.00 74.00 81.00 28.61 23,47 AII C'SsCs 49 20 29 0 2.00 6.00 18.50 26.95 47.15 78.00 81.00 34.73 25.13 ~ Controls 39 14 25 0 35 2.10 9.10 12.35 27.30 36.25 52.001 17.66 14.32 Atl 08 34 54 0 1.35 4.00 10.50 23.00 36.25 74.00 81.00 27.70 22.74 Men 0 Cases 1 0 10 0 ~ i Conlroia 17 0 17 0 € 1 I All 27 0 27 0 i WORrCr1 CasCS 23 16 6 1 0.45 1.00 9.00 31.181 46.50 86.00 99.00 33.36 28.94 Contras 36 ~ 15 G1 0 1.00 1.70 3.00 11.251 E 1 33.50 49.50 51.00 20 .06 ! ~& C: All 59 31 27 0.45 1.70 6.00 23.001 39.00 54.00 99.00 26.921 2a 8 All C3sf5 33 16 16 0.45 1.00 9.00 31.181 46.50 86.00 99.00 33.36 2'c 6a Controls 53 15 38 0 1.00 1.70 3.00 11.25 33.50 49.50 51.00 20.06 tB.OC 86 31 54 0.45 1.70 8.00 23.00 39.00 54.00 99.00 26.92 a e SPAIN M~1 CSSBf 6 1 5 0 4.65 4.65 4.65 4.65 4.65 4.65 4.65 4.65/ 0 OC COnUCls 13 0 13 0 ~ i All 19 11 18 0 4.65 4.65 4.65 4.65 4.65 4.65 4,65 4.650 00 Women C7sC3 86 34 18 13 0.10 2.00 9.00 23.50 38.20 66.00 103.50 28.55 2= ' COn1r01s 146 88IE 37 21~ 0.15 3.001 9.65 23.58 43.50 66.00 ~ ~ /32.00 30.27 25 65 All 211 1221 55 34 0.10 3.00 9.30 23.58 42.00 66.00 132.00 29.79 25 41 All C3503 71 35 23 13 0.10 2.00 7.00 22.00 38.20 66.00 103.50 27.87 25.C CGt1tr0la 159 88 50 21 0.15 3.001 9.65 23.58 43.50 66.00 132.001 30,27 25 65 All 230 123 73 34 0.10 3.00 9.00 23.35 42.00 66.00 132.001 29.5925 d1 (MQn Cases 23 8 15 0 0.25 0.25 1.50 ?.25 19.63 33.00 33.00 11.25 12.02 !! COrltraa 36 9 7 ~ 0 0.90 0.90 1.25 2.40 4.00 19.00 19.00 5.43 6.95 Atl 59 17 42 0 0.25 0.90 1.25 2.50 16.00 23.25 33.00 8.17 9.82 WOr11Cn Cases 47 20 23 4 2.20 2.90 8.90 22.13 38.75 55.75 78.00 26.28 21.24 Controls 76 40 35 1 _ 0.90 1.63 6.00 13.75 24.00 42.63 58.50 17.71 15.46 AN 123 60 58 5 0.90 2.50 6.00 16.58 31.00 46.001 _ 78.00 20.57 17.88 AH Cases 70 28 38 4 0.25 2.00 4.25 ?7.00 33.25~ 47.00 78.00 21.98 20,07 ~ Controls 112 49 62 1I 0.90 1.50 4.00 11.35 21.001 40.25 58.50 15.45 15.01 AA 182 77 100 5( 0.25 1.50 4.00 12.25 26.00 44.75 78.00 17.83 17.19 UNlTED KINGDOM MCn Cases @ 3 0 0 3 Controls 14 0 0 14 I ~ f All 17 0 0 17 ! WOn1Cn Cases 23 0 0 23 COntraa ~ 126 0 0+ 126 ~ All I 149 0 0I 149 F All Cases 26 0 D 26 ~ Conucla 140 0 0 140 ! I AIl 166 0I 01 166 I .~ ~ ®a

D - S3AV Spouse and other cohabifanfs, Average exposure (cigarettesJday) ALL cEKTERs Lave1 of~_xposure NE., S3AV<1 1<S3AV<1 1<S3AV _Cases I Controls OR(1) 95% CI 459 1095 1,00 33 85 0•74 ( 0.48- 1.14) 34 59 1.19 ( 0.75- 1.89) Excluded/Trend! 124! 3031 0.95 ALL CENTERS WITH EDUCATIONAL LEVEL AND TYPE OF RESIDENCE NE., 63AV<K1 1<S3AV<1 1<S3AV Ekc.luded/Trendl ALL CENTERS WITH DIETARY DATA 1721 4501 NE., S3AV<1 351 676 1<33AV<1 22 63 1<S3AV 23 42 Ekcluded/Trendi 113! 2751 FRANCE ME,, 63AV<1 1<S3AV<1 1<S3AV 0.23 1.00 0.61 (, 0.36- 1.03) 0.96 ( 0.56- 1.66) 0.27 OR(3) 95% Ct 1 OR(4) 95% CI 1.00 1 1.00 ~ 1,00 0.64 ( 0.39- 1.04) 0.61 ( 0.35- 1.05)1 0.74 ( 0.48• 1.15) 1.11 ( 0.69- 1.80)~ 1.17 ( 0.67- 2.05)~ 1,21 ( 0.76- 1.91) 0.95 [[ 0.98 0.96 0.99 1.00 I 1.00 1 1•00 F1.00 ( 0.60 ( 0.34- 1.04) 0.61 ( 0.35- 1.05) 0.60 ( 0.34- 1.04) 0.60 ( 0.33- 1.09) ~ 1.17 ( 0.67- 2.03) 1.17 ( 0.67- 2.05) 1.18 ( 0.68- 2.06) 1.21 ( 0•66- 2.24) 0.23 ~ 0.24 0.23 0.24 1.00 0.66 ( 0.39- i•12) 1.02 ( 0.59- 1.77) 0.27 1.00 ' 1-00 1.00 0.62 ( 0.34- 1.13) 0•61.( 0.36- i.02)~ 0.60 ( 0.35. S.OD)~ 1.21 ( 0.66- 2.25)~ 0.97 ( 0.56- 1.67)1 0.99 ( 0.57- 1.71)~ II ~ 0.29 0.27 0.29 ~ 63 109 1.00 1.00 ; 1.00 1.00 1.00 4 13 0.56 ( 0.17- 1.81) 0.68 ( 0.20- 2.33) 0.79 ( 0.18- 3.51) 0.56 ( 0.17- 1.83) 0.55 ( 0.17- 1.79) j 5 17 0.51 ( 0.18- 1.49) 0.55 ( 0.18- 1.68) 0.91 ( 0.24- 3.51) 0.51 ( 0.17- 1.48) 0.52 ( 0.18- 1.53) Exc2udad/Trand 5 1 12 0.14 ~ 0.14 0.14 0.14 0.15 GERMANYI NE., 53AV<+1 1<S3AV<1 1<63AV 46 182 1.00 1.00 1.00 1.00 1.00 5 12 1.18 ( 0.37- 3.75) 1.30 ( 0.39- 4.38) 1.44 ( 0.42- 4.97) 1.21 ( 0.38- 3.88) 1.26 ( 0.39- 4.07) 3 5 1.16 ( 0.26- 5.27) 1.07 ( 0.22- 5.13j 1.06 ( 0.22- S.tS) T.21 ( 0.26- 5.52) 1.23 ( 0.27- 5.68) s Ezc1 uded/Trend 221 301 0.76 0.84 0.75 0. 74 0.71 ( GERMANY 2 NE., S3AV< 1 105 130( 1.00 ( 1.00 1.00 1.00 ` 1.00 1<S3AV<1 6 10 0.54 ( 0.18- 1.61) 0.52 ( 0.17• 1.58) 0.54 ( 0.18• 1.58) 0.54 ( 0.18- 5.59) 0.54 ( 0.18- 1.61) 1<S3AV 5 6 I 0.75 ( 0.21- 2.66) 0.78 ( 0.22- 2.77) 0.83 ( 0.23- 3.03) 0.75 ( 0.21- 2.65) 0.76 ( 0.21- 2.68) E Excludad/Trend 251 17 0.34 ~ 0.37 ~ 0.40 0.34 0.34 GERMANY 3 NE., 83AV<.1 1<S3AV<1 28 46 1.00 1.00 1.00 1.00 1.00 0 1 0.00 ( 0.00•99,99) ~ 0.00 ( 0.00•99.99)~ 0.00 ( 0.00-99.99)~ 0.00 ( 0,00-99.99) 0.00 ( 0.00•99.99)~ Excluded/Trand Ii 31 5 0.99 ~ 0.99 ~ E 0.99 ~ 0.99 ~ 0.99 ~ ITALY I NE,, 83AV<1 1<S3AV<1 1<S,3AV Sxcludid/Trend ITALY 2 NE,, S3AV<1 S<S3AV<•1 1<S3AV Excduded/Trendl 21 ITALY 3 NE., S3AV<1 1<S3AV<.) 1<S3AV 76 1.00 1.00 1.00 ! 1.00 13 0.67 ( 0.13- 3.36) 0.75 ( 0.15- 3.79) 0.72 ( 0.14- 3.69)( 0.70 ( 0.14- 3.53) 10 0.89 ( 0.17• 4.61) 1.05 ( 0.20• 5.52) 1.00 ( 0.19- 5.30)II 0.91 f 0.17- 4.73) 22 0.72 ~ 0.81 0.8f ~ 0.69 150 1.00 1,00 1.00 1.00 0.00 ( 0.00-99.99) 0-00 ( 0.00-99.99) 0.00 ( 0.00-99.99)I 0.00 ( 0.00-99.99) 5 2,89 ( 0.45•18.32) 4.10 ( 0.59-28.32) 16.60 ( 0.39-99.99)i 2.44 ( 0.38-15.77) i € 11] 0.61 0.51 j 0.59 E 0.73 11 30 1.00 1.00 1.00 1-00 1.00 I ! 4 0.43 ( 0.04- 4.78) 0.56 ( 0.05- 6.86)i 0.56 ( 0.03•11.76) 0.00 ( 0•00•99.99) 0.40 ( 0.03- 4.72) ~ 11 0 99.99 ( 0.00•99.99) 99.99 (, 0.00-99.99) 99.99 ( 0.00-99.99)I I 1 99.99 ( 0-00-99-99) 99.99 f, 0.00-99.99) 16 Excluded/Trand~ 3i 0.83 0.91 ~ 0.90 !! ( 0.81 ~ 0.88 1 PORTUGALI NE., S3AV<•1 1<S3AV<1 1<S3AV 34 33 1.00 1.00 9 2 7.05 ( 1,27•39,03) 6.72 ( 1.23•36,64) ~ 4 0 99.99 ( 0.00-99.99) 99.99 ( 0.00-99.99)~ Exc1 uded/Trand 2 4 0.01 ~ 0.01 PORTUGAL2 NE,t u3AV<1 1<S3AV Fxcluded/Trond SPAIN 24 3 NE., S3AV<.1 ~ 42 1<S3AV<1 1<S3AV Pxcluded/Trend1 46 2 1.00 3.37 ( 1.00 0.49-22.99) 3.86 ( I 0.48-31.09)~ 1.00 3.51 ( 0.52-23.89) 0.22 0.13 € 0.22 93 1.00 1.00 1•00 16~ 0.28 ( 0.06- 1.28) 0.28 ( 0.06- 1.33) 0.31 ( 0.07•_1.48) 0.27 ( 0.06• 1.25) 111 1.48 ( 0.52- 4.19) 1.52 ( 0.52- 4.43) ~ 1.58 ( 0.54- 4.65) 1.46 ( 0.51- 4.13) 39 1 0.93 E 0.86 0.93 j 0.96 0.94 NE.E S3AV<s1 ; 61 100 1.00 1.00 1 € 1.00 1.00 4<g3AV<at i 4 7 0.91 ( 0.25- 3.31) 1.00 ( 0.27- 3.73) 1 ' t 0.95 ( 0.26- 3.45) 0.84 ( 0.23- 3.09) 1<S3AV i 2 3 1.42 ( 0.22- 9.18) 1.35 ( 0.20. 8.97) E 1.40 ( 0.22- 9.08) 1.65 ( 0.25-11.02) ( Excludad/Trandl 3 2 0.86 0.82 ~ ~ 0.84 0.84 (1) Model nclude sex, center, sex'eonter and age (2) Model klelude sex, eenter, sex'center, age and proportion of residential type in the last 35 yrs (REUP) (3) Modot (ndude sex, contor, sex-center, age, proporlion of residentfat type in tne last 35 yrs (REUP) and eaucattonal level (EDUO) (4) Model inC(udo sax, conter, sex'center, age and duretion of exposure to list A agents (OCLAY) f51 Mcuinl lrrAlde •nr rmnfer sex•center aae and freouencv Consumotion of veaetabies (VE GE)

®_S3CU Spouse and other cohabitants, Cumulative exposure (packs/day x years) &LLcV-"'M1Rs Le1ral of ex un Cases Controls OR(1 95% CI O 2 95% CI j OR(3 95% Cl OR 4 95% Cl € OR(5 95% CI HE., S3CU<13 447 1095 1.00 1.00 1.00 1.00 1.00 13<$3CU<25 41 86 1.05 ( 0.69- 1.59) 0.93 ( 0.59- 1.47) 0.64 ( 0.37- 1.10) 1.09 ( 0.72- 1.66) 0.93 ( 0.57- 1.52) 25<S3CU 38 58 1.41 { 0.90. 2.21) 1.32 ( 0.82- 2.12j 1.17 ( 0.69- 1.98) 1.43 ( 0.91- 2.25) 1.19 ( 0.69• 2.04) €xcludad/Trand 124 303 0.16 0.16 t 0.15 1 0.16 0.17 ALL CENTERS YNTH €DUCATIONAL LEVEL AND TYPE OF RESIDENCE HE., :,3CU<13 280 774 1.00 1.00 i 1.00 1•00 1.00 13<S3CU<25 20 66 0.63 ( 0.37- 1.10) 0.63 ( 0.37- 1.10) 0•64 ( 0.37- 1.10)1 0.66 ( 0.38- 1.15) 1 0.73 ( 0.41- 1.32) 25<S3CU 26 48 1.16 ( 0.68- 1.97) 1.16 ( 0.68- 1.97) 1.17 ( 0.69- 1.98)~ 1.17 ( 0.69- 1.99)~ 1.19 ( 0.66- 2.15) J __ .:xc1Udad/Trand 172 450 0.71 0.72 0.73 0.72 ~ 0.70 ~ NE., 53CU<13 341 682 1.00 1 1•00 1.00 1•00 1.00 13<S3CU<25 29 58 0.95 ( 0.58- 1.55) 0.99 ( 0.60- 1.64) 0.74 ( 0.41- 1.33) 0.99 ( 0.61- 1.62)1 0.93 ( 0.57- 1.52) 25<S3CU 26 41 1.18 ( 0.69- 2.02)~ 1.27 ( 0.74- 2.19) 1.21 ( 0.67- 2.19) 1.20 ( 0.70• 2.05) 1.19 ( 0.69- 2.04) fxcludad/Trand 11s 275 F 0.71 1 0.71 1 0.70 1 0.69 0.72 FRANCE NE•, S3CU<13 13<S3CU<25 25<S3CU 62 114 1.00 1.00 1.00 1.00 1.00 5 14 0.71 ( 0.24- 2.12) 0.89 ( 0.29- 2.74) 0.33 ( 0.04- 2.91) 0.72 ( 0.24- 2.15) 0.69 ( 0.23- 2.06) 5 11 0.96 ( 0.31- 2.98) 1.09 ( 0.33- 3.59) 1.79 ( 0.40- 7.95) 0.96 ( 0.31- 3.00) 0.97 ( 0.31- 3.02) fxcludad/Trond 51 12 ~ 0.76 0.74 0.81 0.74 0.75 ~ GERMANYI HE., S3CU<13 13<S3CU<.25 25<S3CU 47 185 1.00 1.00 1.00 I 1.00 1.00 2 10 0.51 ( 0.10- 2.49) ~ 0.26 ( 0.03- 2.23) 0.33 ( 0.04• 2.93)! 0.51 { 0.10- 2.51)~ 0.52 ( 0.10- 2.58) 5 4 2.48 (, 0.60-10.20) 2.04 ( 0.47- 8.78) 1.89 ( 0,43• 8.26)pp= 2.50 ( 0.60•10.30)E 2.45 ( 0.58-10.29) fxclrxJad/7rend 22I 30 0.43 1 0.56 ~ 0.51 ( 0.44 ~ 0.47 GERMANY2 HE., S3CU<13 13<S3CU<25 25<S3CU 102 131 1.00 1.00 7.00 1.00 1.00 1 B 8 0.98 ( 0.34- 2.80) 1.00 ( 0.35- 2.87) 0.99 1 0.34- 2,88) 0.98 ( 0.34- 2.80) 1.00 ( 0.35- 2.86) ~ 6~ 7 0,69 ( 0.21- 2.29) 0.65 ( 0.20- 2.18) 0.68 ( 0.20- 2.30) 0.69 ( 0.21- 2.29) 0.69 ( 0.21- 2.30) E'xc1 udad/Trand1 2s~ 17 0.59 1 0.54 ~ 0.59 0.59 1 0.59 GERMANY3 yE,, S3CU<13 25<S3CU 28 46 1.00 E 1.00 1.00 1.00 1.00 ~ 0 1 0.00 ( 0.00-99.99) 0.00 ( 0.00-99.99) 0.00 ( 0.00-99.99) 0.00 ( 0.00-99.99)~ 0.00 ( 0.00-99.99) ~ 5'xcludad/Tnnd 3 51 0.99 0.99 1 0.99 0.99 ~ 0.99 E ITALY 1 HE., 83CU<13 13<83CU<26 25<S3CU 30 175 1.00 1.00 1 1.00 1.00 ' 14 0.23 ( 0.03- 1.92) 0.25 ( 0.03• 2.10) 0.25 ( 0.03- 2.07) 0.25 ( 0.03- 2.03) 3 10 1.09 ( 0.27- 4.43) 1.28 ( 0.31- 5•32) 1.23 ( 0.30- 5.12) i 1.09 ( 0.27- 4.47) :`cludad/7rand l 6 22 0.64 ~ 0.75 0.76 0.61 ~ ITALY 2 NE., u3CU<13 ( 15 145 1.00 1.00 1.00 1.00 t3<S3CU<.25 ~ 0 11 0.00 ( 0•00-99.99) 0.00 { 0.00-99.99) 0.00 ( 0•00-99•99) 0.00 ( 0.00-99.99) 25<S3CU I. 21 6 1.69 ( 0.29- 9.88) 2.14 ( 0•35•13•08) 1.90 ( 0.15-23.50) 1.83 ( 0.31-10•88)1 Excludad/Trandi 21 11 0.96 j 0•s8 0.71 i 0.98 I ITALY 3 NE,, S3CU<13 9 28 13<S3CU<25 3 5 25<S3CU 1 7.00 1.00 1.00 ' 1.00 1.00 1.17 (, 0.21- 6•56) 1.88 ( 0.25-14.06) 1.90 { 0.17-21.72) 1 1.28 ( 0.23- 7.27)] 1.97 ( 0.29-13.50)1 1.62 ( 0.08•31.26) 1.57 ( 0.08-31.14) 0.85 ( 0.04-17.68) 2.11 ( 0.10-43.85)I 1.36 ( 0.06-28.59)I 1 ` S € €xcl0dad/Trand 3! 16 0.74 ~ 0.77 0.95 0.61 ~ o.s €E2 PORTUGALI NE.F S3CU<13 13<S3CU<25 2g<S3CU 36 33 1.00 t 1.00 1 6 2 4.57 ( 0.76-27.35) } 4.47 ( 0.76-26.36) F 5 0 99.99 ( 0.00-99.99) 99.99 ( 0.00-99.99) 1 5`xc1 udad/Tivnd I 2 4 0.01 ~ ~ O.Of ~ PORTUGAL 2 NE,, u3CU<13 20 47 1.00 1.00 ?.00 ~ 1 13<S3CU<25 5 0 99•99 ( 0.00-99.99) 99.99 ( 0.00-99.99) 99.99 f, 0•00-99.99) 25<S3CU 2 `: 7.59 ( 0.55-104.3) 8.02 ( 0.51-125.2) 8.81 { 0.64-120.4}~ j € r:xcluded/Trond s si 0.02 0.01 ~ 0.02 ~ SPAIN NE,, S3CU<13 39 85 1.00 1.00 1.00 1.00 1.00 13<S3CU<25 6 0.69 ( 0•25- 1•93) 19 0.76 ( 0.27- 2•17)( 0.77 ( 0.27- 2.24) 0.78 ( 0.28- 2•20) 0.70 ( 0.25- 1•97)i 25<S3CU 5 1 I 16 0,88 ( 0.31• 2•50) 0.87 ( 0.30- 2.54) 0.89 ( 0.30- 2 65) 0.87 ( 0.30- 2.49) 0.94 { 0.32- 2.74) 1 ! Excludad/Trendl 20 391 0.65 t 0.58 0.57 0.68 0.75 ~ SWEDEN NE., 83CU<13 13<S3CU<25 25<S3CU 1 0.03 (1) Model Inatudo sex, center, sex'center and age (2) Modo) inckldo sox, center, sax'oanter, age and propartfon of residential type in the last 35 yrs (REUP) (3)Mcdelkidede smx, eanter, .:ex'untor, age, propoYlon of rosrdantial type in the last 35 yrs (REUP) and edueaticnal tevel (EDUC) (4) Model ktduda sex, center, sex•center, age and duration of exposure to list A agents (OCLAY) (5) Model include mex, center, sox•oonter, age and frequency consumption of vegetables (VEGE) 1.00 j 1.00 3.28 ( 0•72-15•02)( 4.15 ( 0.86-19.98) 5.12 ( 0•59-63,49)I 6.41 ( 0•60•69,13) 1.00 1 1.00 ! 3.41 ( 0.75-15.58) 3.15 ( 0•68-14•56) ~€ S•28 ( 0.61-64.77) 7.22 ( 0•88-76•27) E 0.04 1 0.04

s1 CU Spouse, Cumulative exposure (packs/day x years) ALL CENTERS Total Exoosed Unexoosed Excluded Min P10 I 01 Median c"13 1 P90 ~ Max Mean I Std Men C.9sef 138 22 116 0 0.10 0.30 0.84 / 3.35 7.76 10.50 14.23! 4.67 -4.30 Controls 517 58 1 451 8 0.03 0.40 1.01~ ~ 2.50 7.86 10.95 4.75 21.43f 5.09 All 672 80 567 25 0.03 0.341 7.00 2.81~ 7.81 10.87 _ 21.43 4.73 4.86 WG(rlCn C3zC3 486 244 181 61 0.01 0.64 2.48 7.20) 15.05 30.88 93.29 ".2.41 15.23 Controls 886 491 327 67 0.01 0.90 2.89 7.00~ 13.80 25.11 68.14 90.6 11.55 All ~ 1520 735 S08 277 0.01 0.83 2.70 7.14~ 14.14 27.00 93.29~ 11.24 12.91 Aq C93C9 650 266 297 87 0.01 0.50 2.33 7.07 14.23 29.86 93.29 11.77 14.79 Controls 1542 549 778 215 0.01 0.83 2.44 6.69 13.00~ 23.14 68.14~ 10.03 11.20 All 2192 815 1075 302 0.01 _ 0.71/ 2.36 6.75 13.50 25.80 93.29] 10.60 12.50 ALL CENTERS WTN EDUCATIONAL LEVEL AND TYPE OF RESIDENCE MGn C83G3 89 11 78 0 0.30 0.84 0.96 3.50 7.76 10.50 12.38 ~ a.56-F 4.02 Controls 456 49 399 8 0.03 0.54 1.03 2.81~ 8.01~ 13.65 21.43 5.15 5.33 All 562 60 477 25 0.03 0.56 1.02 3.10[ 7.94i 11.66 21.43 5.04 5.09 Womon C35M 383 192 136 55 0.01 0.53 2.43 7.02 14.15 30.17 93.29 12.02 15.29 COntr016 742 425 254 63 0.01 1.00 3.28 7.75 14.50~ 25.93 68.14 11.32 12.03 All 1274 617 390 267 0.01 0.90 2.89 7.23 14.50 27.86 93.29 11.54 13.12 AII Ca50s 498 ^03 214 81 0.01 0.53 2.33 6.68 13.75 29.861 93.29 11.62! 14.99 COnttofs 1338 474 653 211~ 0.01 0.93~ 2.80 7.07 14.00 25.11 68.14 10.69! 11.67 All 1838 677 867 292 0.01/ 0.84 2.601 ~ 1 7.001 14.00 26.25 93.29 10.97I 12.75 ALL CENTERS WITH DIETARY DATA Men Cascs 101 i8 83 0 0.20 0.30 0.84 3.20 7.761 12.38 14.23 4.66 4.52 Controls 292 31 256 5 0.03 0.39 1.00 2.50 6.75 9.50 21.43 4.26 4.52 AN 410 49 339 22 0.03 0.31 1.00 2.81 6.75 10.50 21.43 4.41 4.48 Woman Ca3oS 382 187 143 52 0.01 0.50 2.19 7.04) 14.00 29.86 93.29 11.61 14.46 Controls 624 346 230 48 0.02 0.75 3.15 7.37 14.76 25.71 68.14 11.14 11.8; A11 1165 533 373 249 0.011 0.70 2.63~ 7.14 14.63 26.79 93.29 11.31~ 12.8c Ali C95C4 509 205 226 78 0.01 0.44 1.89 6.60 13.59~ 27.86 93.29 i7.00/ 14,0 Controls 1056 377 486 193 0.02 0.75 2.60 6.75 14.25 25.00 68.14 10.58 i7.55 All 1565 582 712 271 0.01 0.60 2.40 6.74 14.00~ 25.93 93.29 10.73 2 4E FRANCE M8n CisC3 14 1 13 0 3.20 3.20/ 3.20 3.20 3.20 3.20 3.20 3.20 0.0. Controls 23 2 20 2.50 2.50 2.50 4.25 6.00 6.00 6.00 4.25 2.4' All 37 3 33 2.50 2.50 2.50 3.20 6.00 6.00 6.00 3.90 WOntefl Ci:@s 63/ 33 26 4 0.14 0.20 0.71 6.00 14.30 26.00 29.86 9.13 9.57 Controls 1281 81 45 2 0.03 0.83 2.57~ 8.49 14.00 23.14 68.14 11.461 12.'~ Ap 191 '.14 71 6 0.03 0.36 2.15 7.631 14.30 25.71 88.14 10.79 11 9: A!I CiSes Controls All "r`7 151 228 34 83 117 39 65 104 4 3 71 0,14 0.03 0.03 0.20 0.83 0.36 0.71 5.31 14.30 2.50 8.36 14.00 2.28 7.14 14.00 26.00 23.14 25.71 29.86 68.14 68.14 8.96 5+, 11.29 12.8: 10.611 ti E' GERAlANY 1 MOn CIDsas 18 3 16 0 0.96 0.96 0.96 4.13 7.76 7.76 7.76 4.28 3 4; Controls 122 9 1 113 4 0.03 0.93 2.19 5.45 8.17 10.79 21.43 6.34 t E• All 147) 15 ~ 128 4 0.03 0.93 :.01 4.34 10.79 7.76 21.43 1 5.93 5 3 WothOn C7ses 58 27 19 12 0.16 0.21 2.85/ 6.41 17.57 30.88 93.29 14.46 2c ~ Controls 100 54 40 6 0.11 1.88 4.15 6.86 12.38~ 24.00~ 0'1.73 10.54 10.6_ AN 168 81 59 18 0.11 0.93 3.76 6.83 13.59) 26.25 93.29 11.85 1~ " All CLSQS 76 30 34 12 0.16 0.33 2.85 6.11 15.86 28.57 93.29 13.44 19 .r; COr1U03 229l 66 153 10 0.03 1.01~ 3.05I 6.77 10.88 23.14 61.13 9.78 10 0: AII 305 96 187 22 0.03 0.93 3.64I 6.66 i2.28, 25.53 93.29 10.92 13.8' CERMANY2 Man 5.67 11.44 12.38 12.38 6.00 6.31 CaSes 29 d 25 0 0.30 0.30 0.57 1 Controls 6s 5 601 0 0.90 0.90 1.50 2.81 6.75 9.90 9.90 4.37 v.8= AII 94 9 85 0 0.30 0.30 0.90 2.81 9.90 `2.38 12.38 5.10 4.8'. WOrf'An 0.01 0.75 2.03 6.80 12.75 29.25 64.88 10.78 14.0( 113 58 41 1 Ci.•C4 ~ L Controls 98 58 38 0.15 0.83 2.55 5.81I 14.63 34.50 58.50 11.89 14.2=~ 211 116 79 16 0.01 0.83 2.22 6.33 14.25 30.38 64.88 11.341 14.0" Ay CL es ~ 142 62 66 141, 0.01 0.75 1.88 6.80 12.38 27.03 64.88) 10.47 13.6c Controls 163 63 98 2 0.15 0.90 2.48 5.48 14.63 30.38 58.50 11.30 13.8• A!1 305 125 164 16 0.01 0.83 2.03 6.15 12.94 29.25 64.88 10.89 13.7~ GERMANY 3 MCn Cases Controls All 10 0 141 1 24 1 10 13 23 0 1 0 1.00 1.00 0 1.00 1.001 1.00 1.00 1.00 7.00 1.00 1.00 1.00( 1.00 1.00 1.00 1.001 0.0: 1.00 0.0 Wor118t1 C9S8s 21 8 12 1/ 1.00~ 1.00 2.68I 5,46I 11.21 46.88 46.88 10.82 15.1 Controls 38 15 22 11 0.23 0.47 1.50 2.25 10.13 . 19.69 25.50 6.02 7.5; All 59 23 34 I 1 2 0.23 0.60 1.88 3.15 11.03 19.69 46.881 7.69 10.7- ~All CLS®s j 31 8 22 1 1.00 1.00 2.68 5.46 11.21 46.88 46.88 10.82I 15.1 Contrals ~ 52 16 35 1~ 0.23 ' 0.47 1.251 2,08 <'.88 19.69 25,50 5.71/ 7.4 All 83 24 57 2 0.23 0.60 '..69 1 3.09 10.58 19.69 46.88 7.41 10.5 ITALY I r.ten Ces03 8 1 7 0 3.50 3.50 3.50 3.50 3.50 ~ 3.50 3.50 3.50 0.0 Controls 103 12 88 3 0.20 0.40 0.70 1.80 9.68 13.65 19.29 5.57 6.3. All 111 13 95 3 0.20 0.40 0.83j 2.00 8.41 13.65 19.29 5.41 6.1 WofnCn CisC3 32 19 9 4 1.60 2.29 3.09 7.07 8.19 39.64 60.80 11.27 15.0 Controls 118 73 35 10 0.01 1.22 3.28 7.22 12.21 21.21 67.00 10.10 11.4 AN 150 92 44 14 0.01 1.35 3.18 .'-.07 12.18 22.50 67.00 10.34 12.1 All C,25QS 40 20 16 4 1.60 2.32 3.29 54 8.17 6. 37.07 60.80 10.88 14.7 Conlrol3 221 85 123 /3 0.01 0.83 2.25 1 7.00 2,14 19.29 67.00 9.46 10.9 Ail 261 101 139 171 0.01 1.00 2.80 7.00 9.73 11.6

D_S1 DH Spouse, Durafion (hours/day x years.) MEN ONLY 1 LlVml 04 osurc Cascs Contrnls OR(1) 95;4 C! OR(2) 95% Ct ©R(3) 95 % C) E OR 4) 95% C/ ( OR(5) 95% CI Non mxposmo ( 116 451 1.00 1.00 1•00 1.00 1-00 0<S1DH<•133 ( 19 48 1.70 ( 0.88- 3.32) 1.71 ( 0.84- 3.45) 1.45 ( 0.56- 3.75) 1.69 ( 0.87- 3.29) 1.83 ( 0.86• 3.89) 935<S10N<.223 2 6 2.02 ( 0.26•15.93) 1.91 ( 0.19-19.68) 0.00 ( 0.00-99.99) 2.10 ( 0.26-16.81) 2.90 ( 0.22•37.69) ~ 223<S1DN 0 1 0.00 ( ~ 0.00-99.99) 0.00 ( 0.00-99.99) 0.00 ( 0.00-99.99) f Ezcludld/Trmnd 4 25 0.16 EE 0.17 0.17 0.16 0.16 WOMEN ONLY Non mxposmo 181 327 00 t.0o 1.00 1.00 1.00 0<810H<.133 148 348 0.80 ( 0.67- 1.06) 1. 0.78 ( 0.58- 1.04) 0.79 ( 0•56- 1.11) 0,82 ( 0,62- 1.08) 0.73 ( 0.53- 0.99) 935<S1DH<.223 42 75 1.12 ( 0.72• 1.74) 1.25 ( 0.78- 2.01) 1.21 ( 0.71- 2.07) 1,22 ( 0.78- 1.90) 1.25 ( 0.75- 2.08) 223<SiDH 41 52 1.70 ( 1.05- 2.75) t•67 l, 0.99- 2.83) 1.39 ( 0.78- 2.49) 1.74 ( 1.07- 2.83) 1.35 ( 0.73- 2.49)' ~rludad/Trand 89 209t 0.03 0.03 0.03 0.03 0.0 €€€E4 POPULATION BASED STUDIES Non mxpoem0 186 577 1.00 1.00 1•00 1.00 1•00 9<S1DH<135 107 273 0.83 ( 0.60- 1.14) 0,85 ( 0.61- 1•18) 0,85 ( 0.58- 1.24) 0.85 ( 0,61• 1.17) 0.83 { 0.58- 1•19) 135<S1QHei233 23 38 1.35 ( 0.74- 2.48) 1.40 ( ~ 0•76- 2•5 8) 1.42 ( 0.71- 2.82) 1.49 ( 0.80• 2.76) 2.19 1.04- 4•62 ( ) 223<S1pH 16 25 1.58 ( 0.77- 3.22) 1.66 ( !` 0.81- 3.41) ( 1.55 0.70- 3. 45) 1.63 ( 0.79- 3.34) 1.89 ( 0.72- 5.00) EXC1udId/Trend 45 ~ 37 0.14 0.15 ~ 0.>7 0.14 0.15 HOSPt7AL BASED STUDIES Non expommd 111 201 1•00 1.00 1•00 1.00 1.00 0<S1DH<135 58 123 1,05 ( 0•68• 1.63) 0.88 ( 0.53- 1•47) 0,89 1:00 ( 0•48- 1.64) 1.04 ( 0,67• 1,62) 0.82 ( 0.49- 1.36) 918<131DH<223 21 43 1.08 ( 0,58• 2.01) 1.19 ( 0•59- Z42) 1.06 ( 0.46- 2.46) 1.16 ( 0,62• 2.19) 0.88 ( 0.43- 1.81) 223<S1DN 25 28 2.07 ( 1,08- 3.99) 1.86 ( 0.86- 4,02) 1.44 !, 0.60- 3.45) 2.09 ( ~-08- 4.04) 1.17 ( 0.51- 2.65) €xcluded/7rend 31 57 0,05 0•06 6 0.05 ( 0.06 l 0.07 EWIT110UT OCCASIONAL SMO KERS Non exposed 221 558 1 , 00 { 1•00 1.00 1•00 1.00 0<SiDH<135 120 283 0.90 ( 0.66- 5.21)I 0.84 ( 0.61- 1.16) 0.74 ( 0.51- 1.06) 0.91 ( 0.67- 1.23) 0.76 ( 0.54- 1.08) 135<S10Hes223 32 63! 1.07 ( 0,65• 1,76)1 1.20 ( 0•70• 2,04) 1.12 (, 0.62- 2•02) 1.16 ( 0•70• 1•94)i 1.29 ( 0.72- 2.30) 2?3<S1DH 34 45 I 1.77 ( 1.04- 3.02) 1.63 ( ~ 0.90- 2•95) 1.34 ( 0.71- 2.55) 1.82 ( 1.07- 3•t0)I 1•29 ( 0•64• 2•59) Ezcludtd/Trmnd a'9 l 155 0.05 0.05 0.07 e 0.05 1 0.06 AGE <55 YEARS Non mxposeo 94 213 1.00 1.00 1.00 1.00 1.00 O<S10H< 135 135 51 108 1.00 ( 0.62- 1.60) 0.97 ( 0.58- t.61) 1.16 ( 0.64- 2.12) 0.97 ( 0.60• 1.57) 0.97 ( 0.57- 1.65) 935<S1 DH<  223 1 15 0.10 ( 0.01• 0.81) 0.00 (, 0•00-99,99) 0.00 ( 0,00-99•99) 0.09 ( 0.01- 0.76) 0.00 ( 0.00-99.99) 223<S1DH E 3 6 0.95 ( 0.18- 4.93) 2.40 ( 0,33-17•49) 2.36 ( 0•32-17•45) 0,98 ( 0.19- 5.15) 99•99 ( 0.00•99•99) r'xcludod/Trond~ f6 19 0.>5 0.15 ( 0.14 0.12 0.15 AG@ 55•84 YEARS Non mxposeo 0<S101-1<135 135<S10H<223 223<S1DH 5xc1 uded/Trend 85 289 1.00 1.00 1.00 7.00 1.00 50 133 0.84 ( 0.52- 1.36) 0.77 ( 0.46• 1.27) 0.59 ( 0.33- T.O6)I 0.85 ( 0.53- 1.38) 0.63 ( 0.35- 1•11) 23 22 2.95 (, 1.44• 6.03) 2.46 ( 1.16- 5•2t) 2.07 ( 0.85- 5.06)4 3•48 ( 1.66- 7•31) 4.04 ( 1.fi0•t0•22) 12 201 1.52 ( 0.64• 3.62) 1•07 ( 0.40- 2.89j 0.97 ( 0.33- 2.90)f 1.53 ( 0.64- 3.64) 1.41 ( 0.45- 4.39) 30 881 0.02 1 0.02 ` 0.02 !I 0.02 0.02 y AGE 55t YEAR Non axposea 108 276 1.00 1.00 1.00 7.00 1.00 0<S10H<13S 64 155 86 ( 0 . 57• 0 . 0.87 ( 0.56- 1,34) 0.91 ( 0.54- 1.54) 0.90 ( 0.59- 1,36) 0•91 ( 0.58- 1.43) 135<S1DH<223 ~ 20 44~ 95 ( 0, 51 0.51. 1.79) 79) 0, 1.18 ( 0.61- 2.30) 1.36 ( 0.63- 2.93) 1.02 i 0.54. T.94) 1.10 ( 0.55- 2.18) 223<S1DH 26 7 2.42 ( 1•26- 4.67) 2 44 ( 1.22- 4.89)~ 2.05 ( 0.92- 4.56) 2.49 !- 1.29- 4.81) 1.60 ( 0.73• 3.50) ~ Ezcluded/Trend 57 ,27 0.02 0.02 I 0.03 i 0.02 0.02 HISTOLOGICALLY CONFIRMED DIAGNOSIS exposma ( 28s Non qegiDH<13S 1 959 135<S1DH<223 ~ 43 223<S1pN 39 776 1.00 1.00 1.00 1.00 1.00 396 0.87 (, 0.67- 1.13) 0.85 i, 0.65• 1.12) 0.87 ( 0.63- 1.19) 0.89 ( 0.68- 1.15) 0.84 ( 0.63- 1.12) 81 1.18 ( 0.76• 1.82) 1.31 ( 0.83- 2.08) 1.25 ( 0.74• 2.11) 1.28 ( 0•83- 1.99) 1.38 ( 0.84- 2.27) 53 1.70 ( 1.05- 2.75) 1.64 ( 0.96- 2.77) 1.47 ( 0.83• 2,62) 1.74 { 7.07- 2.82) 1.46 ( 0.80- 2.69) cxc2uded/Trend1 971 ,234 0.03 0.03 0.04 0.03 0.04 E SQUAMOUS CELL CARCINOMA Non mxpoamc 49 776 1.00 1.00 1.00 i 1.00 1.00 0<S1DH<135 24 396 0.80 ( 0.45- 1.41) 0.62 ( 0.33- 1.15) 0.62 ( 0.31- 1.25) 0.76 ( 0.43- 1.35) 0.61 ( 0.32- 1.18) 135<S1DH<.223 7 81 1.31 ( 0.53• 3.25) 1.54 ( 0.61- 3.88) 1.48 ( 0.50- 4.40)l 1.38 ( 0.55• 3.43) 1.19 (, 0.41- 3.46) 223<$1DH 10 63 2.17 ( 0.92- 5.12) 1.38 ( 0.47- 4•04)~ 1.37 ( 0.45- 4.16)I 2.17 ( 0.92- 5.13) 1.23 ( 0.37- 4.10) E.rcluded/Trend 19 234 0.07 E 0.07 0.08 ) 0.07 0.08 SMALL CELL CARCINOMA e%p04ltl ; Non e8 "78 1•00 y i.00 t 1,00 1.00 1.00 p<S1DH<13S II 18 396 1,11 ( 0,55• 2.21) 1.12 (, 0.55- 2•27)1 1.27 ( 0•59- 2.72) 1.12 ( 0.56- 2.26) 1.11 ( 0.54- 2.28) : ';35<S1DH<r223 ~ 6 81 2.51 ( ~ 0.87- 7.27) 2.55 ( 0.87- 7•50) 2.72 ( , 0.82• 9,00) 2.64 ( 0.90• 7.73) 2•20 C 0,69• 7:02) 223<S1DH 2 5-3 2.27 ( 0.45-11.50) 2.21 ( 0.43-11.29) 2.71 ( 0.51-14.21) 2.28 ( O.aS-t1.55)I 1.28 { 0.15-11.17) EzcSudadiTrmnd ~ 161 234 0.09 ! l 0.10 ~ 0.11 0.08 lllt 0.08 ADENOCARCINOMA Non exposno 159 778 t•0o 1•00 t.oo 1.00 ! 1.00 O<S10H<r135 l 86 396 0.80 ( 0.58- 1.10) 0.78 ( 0.55- 1.10) 0.78 ( 0.52- 1.17) ~ 0.83 ( 0.60- 1.15) 0.76 ( 0.53- 1.09) 133<S1DH<  223 l 223 22 91 1.04 (, 0,60• 1.80) 1,18 ( 0,65- 2.13) 1.22 ( 0•63- 2.36) 1.14 ( 0.66• 1•99)~ 1.27 ( 0.69- 2.35)~ 2?3<51DH 20 ~ 53 1•54 ( 0.84- 2.79) 1•59 ( 0•82- 3•06) 1.25 ( 0.60- 2.63) 1.57 ( 0.86- 2•87)' 1.30 ( 0.61- 2.76) Excludad/Trend 46 234 0.20 0.18 ~ 0.20 ~ 0.21 1 0.24 ) OTHER Non mxposeo 0<S1DN<>135 135<S10H<.223 223<S10H tzcludmd/Trsnd 53 778 1.00 1.00 1 00 . oo . 1 1.00 ~ 31 396 0.99 ( 0.59- 1.66) 1.07 (, 0.62- 1.86) 1 ,02 ( 0.54- 7.95) • 03 0.61- ( 1 1.74) 1. { 17 0.62- 2.01) 1 8I 81 1.12 ; 0,49• 2.59) 1.21 ( 0•49• 2.98 ) ( 1.00 0.35. 2.86) 1.23 0.5°- ( 2.87) ( 1.64 0.64- 4.77) ~ f 53 1.62 ( 0.64• 4.06) 1.87 ( 0.72- 4.82) 1.68 ( 0.60- 4.73) 1.71 ( 0.68- 4.30) ~ 2.47 ( 0.85- 7.17) ! I 16 234 0.35 0.37 0.38 0.33 0.34 ~ >75x OF L)FESPAN IN RURAL AREA OR INTERMEDIATE CITIES Non mxposmo 115 270 1.00 1.00 1.20) 0.78 ( O<g10H<135 [ 62 146 0.78 ( 0.51- ~ 16~ 151 2.24 ( 0.97- 5.20) 2.24 (, 3.61 223<S10H i4 9 3.61 ( 1.31• 9.98) eluded/Trend~ 49~ 1051 0.00 0.00 :x e luded /Trend~ ( 57354 OF LIFESPAN IN URHAN AREA Non mxposmtl 703 351 1.00 1.00 1.00 1.00 1.00 ( 0.5t• 1.20)( 0.63 ( 0.38- T.06) 0.77 ( 0.50- 1.20) 0.71 ( 0.45- 1.12) .97- 5.20)I 0.97- 1.80 ( 0.68- 4.76) 2.30 ( 0.99- 5.35)f 1.94 ( 0.79- 4.77) 1.37- 9.98) f 2.79 ( 0.87- 8.96) 3.71 ( 1.34•10.26)i ^<.10 I 0.70- 6.29) i 0.00 . 0.00 { 0.00 t.oo t.oo 1.00 0<S1DH<135 671 201 0,85 ( 0,55• 1.27) 0.85 ( 0.56• 1•27) 0,98 ( 0.61• 1.58) 0.83 ( 0.55- 1.26) 0.90 ( 0,56• 1.43) 135<S1oH<223 22'E 51~ 1.14 ( 0.62- 2.10) 1.14 ( 0•62- 2,10) 1.20 ( 0.59- 2.42) 1.17 ( 0.63- 2.18) 1.44 ( 0.71- 2.94) 223<S10H 1 18 34 1.75 (, 0,88• 3.47) 1.75 ( 0.88- 3.47) 1.57 ( 0.73- 3.36) 1.74 ( 0.87- 3.45) 1.94 ( 0.83- 4.53) ExcludPd/Tr?nd 34 I 741 0.11 0.11 0.11 ) 0.12 0.11 (3) Model indud0 sex, oontef, sex'Center, age, propor(ron of res den(lal type in the last 35 yrs (REUP) and educational level (EDUC) (4) Model include scx, cmntcr. sex'center, age and duration of exnosure co list A agencs (OCtp.Y) (5) Model Indude sex, center, se%'center, age and frequency ronsumption of vegetetles (VEGE) ! 2206359336 Risk estimates - Spouse

E _S3EV Spouse and other cohabitants, ever exposed MEN ONLY Lwe! Of expowrn Cua s f Controts OR(1} 95% C{ O 2) 95X CI O 3 95% CI ®R 4) 95% CI ( ®R(5 95% CI Non oxposeo 100 405 1.00 1.00 1.00 00 1. 1. 00 Exposed 41 125 1.45 ( 0.91- 2.33) 1.46 ( 0.87- 2.44) 1.58 ( 0.82- 3.03)1 1.52 ( 0.94- 2.45) 1.79 ( 1.03• 3.10) ~ €xc,t udid/Trvnd © 1 ~ WOMEN ONLY Non eXpOSeO 160 312 1.00 1.00 1.00 1.00 1.00 Exposed 347 698 1.01 ( 0.79• 1.29) 1.00 ( 0.77- 1.30) 0.94 ( 0.70- 1.27) 1.02 ( 0.80- 1.30) 0.96 ( 0.73• 1.26)1 €xclud.d/Tr.nd 2 f ~ ~ POPULATION BASED STUDIES Non oxposod 163 510 1.00 1.00 1.00 1.00 1.00 Exposed I 213 4391 1.12 ( 0.85- 1.49) 1.13 ( 0.85- 1.51) 1.14 ( 0.82• 1.60) 1.14 ( 0.86- 1.52) 1.24 ( 0.91- 1.70) €xcludad/rrand~ 2 9 HOSPITAL BASED STUDIES Non e%pOfetl 89 153 1.00 1.00 ' 7.00 i 1.00 1.00 Exposed 157 298 1.01 ( 0.70. 1.46)~ 0.89 ( 0.58- 1.38) 0.78 ( 0.45- 1.36) 1.04 ( 0.71• 1.51) 0.79 ( 0.50- i.23)1 - ~ €xcluded/Trand 0 9 • 4MTHOUT OCCASIONAL S!NOKERS Non exposod 190 515 1.00 1.00 1.00 ~ 1.00 1.00 Exposed 588 295 1.20 ( 0.93• 1.56) 1.17 ( 0.89- 1.54) 1.01 ( 0.75- 1.38)1 1.21 ( 0.94- 1.57) 1.11 ( 0.83• 1.50) €xc,rudedirrand i AGE <85 YEARS Non exposed Exposed €xoludad/Trand AGE 65=64 YEARS Non exposed Exposed 82 82 1931 1.00 167) 1.02 ( 0.67- 1.55) ~ 1.00 1 .00 ( t.oo 1.00 0.94 ( 0.59- 1.50) 1.02 ( 0.59• 1.79)i 1.04 t, 0.68- 1.60)~ 1.10 ( 0.68- 1.78) 33 250 1.00 1.00 1.00 1.00 1.00 ( 127 302 0.99 ( 0.66- 1.48) 0.89 ( 0.58- 1.36) 0.67 ( 0.41- 1.09)~ 0.98 ( 0.65• 1.48) 1.00 ( 0.62- 1.61) €xcluded/Trend~ o~ 0 ~ E € AGE 6ffi+ YEARS Non exposed Exposed 8s 179 €xcluded/Trend! 11 HISTOLOGICALLY CONFIRMED DtAGNOSIS Non expose0 252 Exposed 373 SOUAMOU j Exoluded/Trend i CELL CARCINOMA 74 1.00 1.00 1.00 354 1.25 ( 0.89- 1.76) 1.37 ( 0.96- 1.96) 1.49 ( 0.97- 2.31) 717 1.00 ~ 1.00 I 823 1.08 ( 0.87• 1.34)i 1.07 ( 0.85- 1.35) 1 2f t 1.00 1.07 ( 0.81• 1.40) 1.00 1.27 ( 0.90- 1.80) 1.00 1.10 ( 0.88- 1.37) 1.00 1.20 ( 0.82- 1.75) 1.00 1.10 ( 0.85- 1.41) Non expOSaO 43 717 1.00 1.00 1.00 1.00 1.00 Exposed ~ ' 66 823 1.06 ( 0.67. 1.67)1 0.89 ( 0.55- 1.46) 0.81 ( 0.46• 1.42)1 1.04 ( 0.65- 1.65)~ 0.79 ( 0.47- 1,34) €xcluded/Trendi 0 2 SMALL CELL CARCINOMA Non exposea i Exposed i €xcluded/Trend ADENOCARCINOMA Non exposed Exposed 30 39 > :r7 823 2 1.00 1 1.00 1.09 ( 0.62• 1.92) 1.03 ( 0.58- 1.84) 1.00 1.06 ( 0.56• 1.99) 1.00 1.10 ( 0.62- 1.95) 1.00 1.08 ( 0.60- 1.93) 133 '17 1.00 1.00 1.00 1.00 1.00 200 823 1.07 ( 0.81• 1.42) 1.12 ( 0.83- 1.52) 1.10 ( 0.77• 1.57) ~ 1.11 ( 0.84- 1.47)~ 1 .18 ( 0.86- 1.62) €zcluded/Trendl 0~ 2 OTHER Non exposed 46 717 Exposed 68 823 1.00 1.00 T1. 00 1.00 1.10 ( 0.71- 1.71)1 1.10 ( 0.69• 1.76)1 1.19 ( 0.69- 2.05) 1.16 ( 0.74- 1.80) €zcluded/rrnndi ~I 21 >75% OF LIFESPAN IN RURAL AREA OR INTERMEDIATE CfT1ES Non exposed 110 Exposed 146 1 1.00 1.13 ( 0.69- 1.87) 268 1.00 1.00 1.00 1.00 1.00 305 1.01 ( 0.71- 1.44) 1.01 ( 0.71- 5.44) 0.83 { 0.55• 1.27) 0.99 ( 0.69- 1.42) 0.90 ( 0.62- 1.32) €xcluded/Trend v ~ { ~ >75% OF LIFESPAN IN UR®AN AREA aXpOSBC 86 Non Exposed 158 313 1.00 E 1.00 1.00 1.00 1.00 397 1.14 ( 0.80- 1.63) 1.14 ( 0.80• 1.63) 1.30 ( 0.86• 1.96)~ 1.13 ( 0.79- 1.62) 1.28 ( 0.85• 1.93) .xcluded/Trend~ © ,°~ ~ ~ (1) Model incfutle sex, center, sax•eanter and age (Z) htOdst icrhEda sox, can(er, sex•carrtar, aq0 and prgpOrtian of residential typa in tne tast 35 yra (REUP) (3) Modal include sax, canter, sex'canter, age, proportion of residential type in the last 35 yrs (REUP) and educatialal level (EDUC) i41 Modet intJuds sex, carter, sex'oanter, age and duration of ex0osure to list A aaents (OCLAY)

C S3AV Spouse and other cohabitants, Average exposure (cigarettes/day) Non exposed 0<S3AV<.o.51 0.51<S3AV<0.85 0.85<S3AV Exc1 udrd/Trend 1.00 1.03 ( 0.80- 1.32) 0.75 ( 0.47- 1.18) 1.21 ( 0.75- 1.96) 0.94 ~ ALL CENTERS VVITH EDUCATIONAL LEVEL AND TYPE OF RESIDENCE Non exposed 0<S3AV<0.51 0,51<S3AV<0.85 0.85<$3AV 158 126 19 23 7.00 487 292 1.01 ( 0.74- 1.40) 67 0.60 ( 0.34- 1.07) 42 1.18 ( 0.66- 2.11) 450 0.27 ckcludmd/Trand1 ;72 ALL CENTERS WITH DIETARY DATA ~~~-~ Non eXposetl 0<S3AV<0.61 0.51<S3AV<•0.85 0.85<S3AV Excludmd/Trend FRANCE Non exposed 0<S3AV<0.51 0.51<S3AV<0,85 0,85<S3AV 5rcludmd/lrend GERMANYI Non exposed 0<S3AV<0.51 0,51<S3AV<0,85 0.85<S3AV €xcluded/rrfnd 06 1.00 270 1.05 ( 0.79- 1.40) 63 0.63 ( 0.36- 1.08) 42 0.99 ( 0.56- 1.75) 275 0.38 OR(2) 95% CI - OR(3) 95% CI OR(4) 95% CI OR{5) 95% CI 1.00 1.02 ( 0.64 ( 1.12 ( 0.94 0.78- 0.39- 0.68- 1.33) 1.07) 1.86) 1.00 0.97 0.60 1.15 0.99 ( 0.70- ( 0.33. ( 0.64- 1.34) 1.06) 2.07) 1.00 1.05 ( 0.76 ( 1.24 ( 0.94 0.82- 1.36) 0.48- 1.21) 0.77- 2.01) 1.00 1.04 ( 0.61 ( 1.01 ( 0.92 0.78- 0.35- 0.57- 1.40) 1.05)i 1.79)~ 1.00 1.00 1.01 ( 0.74- 1.40) 0.97 ( 0.70- 1.34) 0.60 ( 0.34- 1.08) 0.60 ( 0.33- 1.06) 1.18 ( 0.65- 2.11) 1.15 ( 0.64• 2.07) 0.27 ~ 0.24 1.00 1.00 1.00 1.00 1.02 ( 0.76- 1.38) 1.00 ( 0.69• 1.43) 1.06( 0.79- 1.42) 1.04 ( 0.78- 1.40) 0.67 ( 0.39- 1.17) 0.62 (, 0.33- 1.16) 0•63 ( 0.37- 1.08)I 0.61 ( 0.35- 1.05) 1.03 ( 0.58. 1.84) 1.21 ( 0.63- 2•32) 1.00 ( 0.56- 1.77) ' 1.01 ( 0.57- 1.79) 0.38 0.35 0.39 ( 0.39 34 49 1.00 1.00 1.00 1.00 1.00 29 60 0.75 ( 0.38• 1.47) 0.48 ( 0.21- 1.06) 0.32 { 0.10- 0.99) 0.72 ( 0.36- 1.43) 0.71 ( 0.36- 1.43) 4 13 0.47 ( 0.14- 1.63) 0.44 ( 0.12- 1.63) 0.43 ( 0.09- 2.12) 0.46 ( 0.13• 1.60) 0.45 ( 0.13- 1.57) 5 17 0.44 ( 0.14- 1.35) 0.36 ( 0.11- 1.21) 0.52 ( 0.12- 2 25) 0.42 ('0.14- 1.31) 0.44 ( 0.14- 1.36) 5 12 0.10 0.09 0.08 ~ 0.09 0.11 28 138 1.00 1.00 1.00 1.00 1.00 20 44 1.60 ( 0.75• 3.40) 1.51 ( 0.65- 3.54) 1.45 ( 0.61- 3.42) 1.78 ( 0.82- 3.86) 1.77 { 0.82- 3.81) 5 12 1.47 ( 0.44- 4.93) 1.58 ( 0.44- 5.72) 1.71 ( 0.46- 6.29) 1.59 ( 0.47- 5.40) 1.65 ( 0.48- 5.68) 3 5 1.45 ( 0.30- 6.94) 1.31 { 0.26- 6.65) 1.27 ( 0.25• 6.52) 1.60 ( 0.33- 7.72) 1.63 { 0.33- 7.96) 22 30 0.49 ~ 0.62 0.57 0.49 0.44 GERMANY2 Non expOsetl 0<S3AV<0.61 0.51<S3AV<0.85 0.85<S3AV Ercl uded/Trend 60 91 1.00 1.00 1.00 1.00 i.00 45 39 1.15 ( 0.62- 2.14) 1.06 ( 0.57- 1.99) 1.0t ( 0.53- 1.90) 1.15 ( 0.62- 2.13) 1.13 { 0.61- 2.09) ~ 6 101 0.56 ( 0.19- 1.79) 0.55 ( 0.18- 1.74)~ 0.52 ( 0.16- 1.67) 0.58 ( 0.19- 5.80) 0.58 ( 0.19- 1.80) 6 0.81 ( 0.22- 2.99) 0.80 ( 0.21- 2.98)f 0.64 ( 0.22- 3.17) 0.81 ( 0.22- 2.98) 0.81 ( 0.22- 2.98) ~ 26 771 0.47 0.45 ~ 0.45 0.47 0.47 GERMANY3 Non exposod 0<53AV<0.61 0.51<S3AV<0.85 21 31 1.00 1.00 1.00 1.00 € 1.00 7 15 0.64 ( 0.19- 2.15) 0.64 ( 0.19- 2.22) 0.37 ( 0.09- 1.45) 0.53 ( 0.14- 1.94) 0.51 { 0.14- 1.81) I 0 1 0.00 ( 0.00-99.99) 0.00 ( 0.00-99.99) 0.00 ( 0.00•99.99) 0.00 ( 0.00•99.99) 0.00 ( 0.00-99.99) ~ 1 ~ €.rclrMed/Trrnd 3 5 0.27 0.27 0.10 0.30 0.21 ITALY I Non oxposod 14 103 1.00 1.00 1.00 1.00 0<S3AV<0.51 16 73 0.95 ( 0.40- 2.22) 1.20 ( 0.50- 2.90) 1.10 ( 0.44- 2.72) 1.18 ( 0.48- 2.92) 0.61<53AV<.0,85 2 13 0.65 ( 0.12- 3.51) 0.84 ( 0.15- 4.63) 0.76 ( 0.14- 4.27) 0.78 ( 0.14- 4.28) 0.85<S3AV 2 901 0.86 ( 0.15- 4.79) 1.17 ( 0.20- 6.73) 1.06 ( 0.18- 6.14) 1.00 ( 0.18- ".65)1 £xCluded/Trfnd 6 22 0.71 0.83 , 0.82 0.69 , t Non exposod 10 95 1•0o 1.00 t.oo t.oo t ~ 0<S3AV<0,51 5 55 0.31 ( 0.09- 1.13) 0.24 ( 0.06- 0.97) 0.17 f 0.03- 1.04) 0.29 ( 0.08- 1.04) 0.8t<S3AV<0.83 0 7 0.00 ( 0.00•99.99) 0.00 ( 0.00•99.99) 0.00 ( 0.00•99.99) 0.00 ( 0.00-99.99) ~ 0.85<S3AV 2 5 1.65 { 0•23-11.60)~ 2.10 ( 0.27-16.45) 17.02 ( 0.17-99.99) 1.37 ( 0.20- 9.47) 5xC14ded/lrfnd 2 '> 0.95 0.98 0.89 0.81 t ) ITALY 3 Non oxposed 0<S3AV<0.51 0.51<S3AV<0,85 0.85eS3AV €xcluded/Trend PORTUGALI Non expOseO 0<S3AV<0.51 0.51<S3AV<0.85 0.85<S3AV r"xcluded/Trend PORTUGAL2 Non exposed 0<S3AV<0.51 0.05<S3AV SPAIN i-~rc1 uded/Trend 22 7,00 81 8 6.78 1 4 1.25 il 0 99.99 3 16 0.31 20 14 e 7 1.00 16 0.86 2 6.53 0199.99 4 0.01 30 16 2 5 1.00 2.25 5.30 0.11 1.00 1.00 1.00 1.00 ( 1.20•38.40) 6.24 ( 1.05-37.12) 3.24 ( 0.40-26.45) 6.67 ( 1.15-38.55) 8.98 ( 1.17•68.70) ( 0.09-17.59) 1.51 ( 0.10-23.47) l 1.00 ( 0.04-23.18) 0.00 ( 0,00-99.99) 1.52 ( 0.09-26.40) ( 0.00-99.99) 99.99 ( . 0.00•99.99) 99.99 ( 0.00-99.99) 99.99 ( 0.00-99.99) 99.99 ( 0.00-99.99) 0.38 1 0.53 t 0.50 ( 0.34 1.00 ( 0.29• 2.54) ~ 0.91 (, 0.29- 2.79) ( 1.08•39.54) 6.39 ( 1.06-38.40) ( 0•00•99.99) 99.99 ( 0.00-99.99) 0.01 1.00 1.00 ( 0.70• 7.21)~ 1.37 (. 0.35- 5.37) 2.15 1 ( 0.66- 7.03)i ( 0.68-41.22) 4.50 ( 0.50•40.75) E 5.33 ( 0.69-41.23) 0.09 ~ ` 0.11 ~ Non exposed 19 35 1.00 1 1.00 t 1.00 1.00 1.00 O<g3AVe.0 51 1 . 23 58 0.68 ( 0.31- 1.50)1 0.79 ( 0.34- 1.88) 0.76 ( 0.31- i.86) 0.71 ( 0.32- 1.59) 0.66 ( 0.30- 1.48) 05 0.51<33AV<0. 05 2 16 0.22 { 0.04- 1.09) 0.24 ( I 0.05- 1.26) 0.26 ( 0.05- 7.37) 0.22 ( 0.04- 1.09) 0.22 ( 0.04- 1.11) 0.85<S3AV 1 11 1.15 ( 0.36• 3.67)I 1.30 ( 0.38- 4.40) ~ 1.30 ( 0.37- 4.53) 1.16 ( 0.36- 3.73) 1.24 ( 0.38- 4.05) tixeludmd/rrfnd 20 39 0.80 ~ 0.73 0.81 ' 0.82 0.91 SWEOEN Non exposed 0<S3AV<0.51 0,51<S3AV<0.85 0.05<S3AV 32 521 1.00 1.00 j 1.00 1.00 E 29 48 1.14 (, 0.58• 2.22) 1.12 ( 0.57- 2.21) ; 1.15 ( 0.58- 2.26) 1.15 ( 0.59- 2.27) ~ 4 7 0.97 (, 0.25- 3.69) ~ 1.05 ( 0.27- 4.11)~ 1.02 ( 0.27- 3.87) 0.91 ( 0.24- 3,47) 2 3 1.53 ( 0.23•10.30) 1.45 ( 0.21•10.08) ~ ~ 1.52 ( 0.22-10.25) 1.79 ( ~ 0.26-12.47) £xcludmd/Trfnd~ 3 2 0.75 i 0.72 ! 0.72 0.71 UNITED KINGDOM 2063593431 t (1) Model inc)ude sox, conter, sex'conter and age (2) Modal ktchude sex, eenter, sex'center, age and proportion of residential type in the last 35 yrs (REUP) j?JMedo1 ~rrd:,wv svx, canfef sax canter, irge, pmpartion of rasidentiat type in the tast 35 yrs (REUP) and educational level (EDUG) (4) Model atcLda sax, conter, sex'center, age and duration of exposure to list A agents (OCLAY) (5) Modo) Irtclude sox, contor. sex'canter, age and fraouency consumotion of vegetahles (VF(' E)

S1 CS Spouse, Cumulative exposure of smoking spouse (packsiday x years) ALLCENTERS I Tot]1 Exposed UnecAa,ed Exduded Min ~ P10 Q1 r E Median 03 P90 Max € Mean t Std MCrt Cds" 99 18 81 0 .25 0 3.20 1.00 9.13 18.00 30.00 33.00 11.71 10.18 ConlrOlS 438 59 978 1 0 .25 ~ 1.25 .40 ~ 2 6.00 19.00~ 30.00 48.00 11.43 11.81 All 672 77 459 136 0.251 2.50 1.00 6.50 18.00/ 30.0048.00 11.49 11.39) WOnIMI CisQb 352 188 127 37 0.10 2.80 10.00 24.15 40.05 65.50 135.00 [ 28.74 24.23 Controls 749 440 267 42 0.15 3.00 8.50 21.25 37.00 54.00 336.00 26.28 25.86 All 1520 628 394 498 0.10 3.00 8.95 22.00 I 38.00 57.00 336.00 27.02 25.39 AN Cases ®50 206 208 236 0.10 2.00 8.50 22.75 38.00 62.50 135.00 27.25 23.82 Controls 1542~ 499 645 398 0.15 2.10 6.90 19.00 35.00 52.00 336.00 24.52~ 25.08 All 21D2 705 853 634 0.10 2.10 7.00 20.00 36.00 54.00 336.00 25.32 24.73 ALL CENTERS YYITM EDUCATIONAL LEVEL AND TYPE OF RESIDENCE MCn CASCS 50 7 43 0 1.00 1.00 3.20 8.25 18.00 ! 20.70 20.70 9.40 . 7.47 Controls 377 50 326 1 0.25 1.65 2.80~ 6.75~ 21.50 30.50 48.00 12.51 12.231 Atl 562 57 369 136 ~ 0.25 1.60 ~ 2.90~ 7.001 19.00 30.00 48.00 12.13 11.741 WOn'fOn 0'.3sC5 249 135 82 32 0.10 2.00 9.00 22.50 38.50 62.00 135.00 27.44 23.781 Controls 606 371 194 41 0.15 3.00 9.70~ 22.50~ 38.50 56.00~ 336.00~ 27.78 27.101 Alt 1274 508 276 492 0.10 3.00 9.60, 22.50 38.50 60.00~ 336.00 27.69 26.231 AII Cases 498 142 125 231 0.10 2.00 8.50 21.50 37.80 62.00 135.00 26.55 23.56 Controls 1330 421 520 397 0.15 2.50 7.50 21.00 37.00 54.00 336.00 25.97 ~ 26.25I AH 1838 583 645 628 0.10 2.25 7.50 21.00 37.00 26.11 55.50 336.00 1 25.58 ALL CENTERS WITH DIETARY DATA MCn CasCs 62 14 48 0 0.25 1.00 2.00 6.45 18.00 23.251 33.00 10.41~ 10.221 Controls 213 30 183 0 f 0.25 ( 1.13 1.80 ~ 3.63 19.00 29.00~ 48.00 10.62 12.361 Afl 410 44 231 135 0.25i 1.00 1.90 4.33 ^:8.50 27.00 48.00 10.56 11.61 WorttM CasCs 246 128 89 31 0.10 2.00 8.60 22.50~ 38.35 62.00 103.50 26.30 21.59, Controls 488 287 170 31 0.15 3.75 10.00 21.50~ 40.00 57.00 336.00 28.09 28, 841 All ',155 415 259 481 0.10 3.00 9.30 22.00~ 40.00 58.00 336.00 27.54 26.801 A7 Ci5@s 509 142 137 230 0.10 2.00 6.25 20.35 37.00 60.00~ 103.50 24.73 21.261 Controls 1056 317 353 386 0.15 2.15 7.50 19.20 38.00~ 55.48 336.00 26.44 28.161 Afl 1565 459 490 616 0.10 ^c.00 7.25 19.75I 37.60~ 55.50~ 336.00 25.91 26.21f FRANCE Men Cases 14 1 13 0 3.20 3.20 I 3.20 3.20 3.20 3.20 3.20 3.20 0.00 Controls 23 3 20 0 1.80 1.80i 1 1.80 2.50 6.00 6.00 6.00 3.43 2.25 All 37 4 33 0 1.80 1 1.80 2.15 2.85 4.60 6.00 6.00 3.38 1 .84. WOrnCrt C8588 63 35 25 3 0.15 0.50 5.00 22.50 40.00 52.00~ 76.00 24.01 21.29 Controls 128 82 45 0.23 3.25 9.00 24.38 40.00 52.00 117.00 26.54 21.36 A11 191 117 70 4 0.15 1.75 7.00 23.90 40.00 52.00 117.00 25.78 21.29 AN Cases 77 36 38 3 0.15 0.50 1 4.50 20.70 38.50 52.00 76.00 23.43 21.26; Controls 151 85 65 1. 0.23 2 15 7.00I 23.90 39.00 52.00 117.00 25.72 21.48: All 2281 1211 103 41 0.15 1.80 6.00 23.00 39.00 52.00 117.00 25.041 21.32' GERMANYI Men Casos 18 3 15 0 1.00 1.00 1.00 18.00 20.70 20.70 20.70 13.23 10.68 Contr0lt 129 16 113 0 0.25 1.35 2.45 11.25 26.00 35.00 48.00 15.84 14.35 All 147 19 128 0 0.25 `;.001 2.00 12.50 25.00 35.00 48.00 1 15.43 13.61 Women Caset t 38 29 19 10 0.75 2.00 6.70 22.50 35.00 51,151 70.00 23.99 18.69 Controls 100 58 40 2 0.15 5.40 12.00 19.40 35.75 72.501 336.00 33.23 46.47 All ~ 188 "a7 59 12~ 0.15 4.20 10.50 20.00 35.75 64.00 336.00 30.15 39.55 AII C75Es 76 32 34 10 0.75 2.00 6.53 20.35 34.30 43.90 70.00 22.981 18.25 Controls 229 74 153 2 0.15 2.90 10.00 19.00 33.00 64.00 336.00 29.47 42.20 AM 305 108 187 12 0.15 2.00 9.70 19.00 33.60 62.00 336.00 27.51 36.68 GERMANY 2 Mon Casea 28 0 01 29 E Controls 85 0 0~! 65 E ~ AU 94 0 01 94 7 WOnicn _ Ciset 113' 0 0 113 ' COntrols i 96! 0 0 98 1 All 211I 0 0 211 ~ ~ Ail CssCf 1421 0 0 142 ~ Contrcls 163 0 0 163j All 305 0 0 305 ~ rn McYt CasOs Controls All 10 14 24 0 0 0 0 0 0 10I 14I 24` 1 ~. WOn1Cn C8509 21 0 0 21 {{ I ~ Controls 38 0 0 38 AJI 59 0 0 5 9 !! Afl C9sC3 31 0 0 31 I CanUClS 52 0 0 52 - ~! AII 83 0 0 83 ~ M0n Cesfs 8 7 0 10.00 10.00 10.00 10.00 10.00 10.00 10.00 10.00 0.0( Controls' 103 14 88 1~ 0.30 0.80 5.00 10.85 27.751 39.00 40.00 15.51 14.0: AII 111 15 95 1 0.30 0.80 5.00 10.00 27.75 39.00 40.00 15.14 13.5 Womcn C,seS 32 19 9 4 3.75 4.00 10.00 30.00 45.00 76.00i 135.00 32 . 86 31.7. Controls 118 76 35 7 0.30 2.10 '.70 21.88 34.05 51.75I 83.00 23.95 18.8.- AII i50 I 95 44 11 0.30 3.00 7.50 22.00 34.10 53.25 135.0_01 25.69 22.0'. AH CSsCi 40 20 16 4 3.75 4.25 10.00 30.00 39.00 68.00 135.00 31.53 31.3! Controls 221 90 123 8 0.30 2.10 6.00 21.55 33.00 47.25 83.00 22.63 18.3, . At/ 261 110 139 12 0.30 2.80 6.40 21.68 33.00 49.63 135.00 24.25 21.4.

WOTS Workplace, Time since last ETS exposure (years,) Tolal Exoosed Unexposed Exduded Min P10 01 Median 03 ~ P90 Max Mean Std j MCO CaSCS 152 104 47 1 0.00 0.00 0.00 5.00 14.50 31.00 52.00 9.92 12.91 Controls 580 388 192 0 0.00 0.00 0.00 6.00 16.00~ 31.00 54.00 ~ 10.51 12.65 AIl 732 492 239 1 0.00 0.00 0.00 6.00 16.00~ 31.00 54.00 1 10.39 12.69 Womm1 Cr-C3 531 262 268 1 0.00 0.00 1.00. 9.00 23.00 39.00! 57.00 14.08 15.19 COnlrWi 1076 476 599 1 0.00~ 0.00 2.00i 13.50 32.50 44.00I 57.00 18.23 16.62 All 1607 738 867 2 0.00 0.00 2.00I 11.50 29.00 42.001 57.00 16.76 16.24 AA cases 663 366 315 2 0.00 0.00 0.00 7.00 20.00 38.00 57.00 12.90 14.68 Controls 1656 864 791 1 0.00 0.00 1.00 10.00 25.50 40.00 57.00 14.76 15.44 AN 2339 1230 1106 3 0.00 0.00 0.00 9.00 24.00 39.00 57.00 14.21 15.24 30UAMOUS CELL CARCINOMA cn CaiSCS Controls AN 8 580 f 808 18 388 406 10 192 202 0 0 0 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 4.50 31.00 6.00~ 16.00 6.00 16.00 40.00 31.00 31.00 44.00 54.00 54.00 13.78 10.51 10.66 ~ 17.13 12.65 12.871 WCmCn C85CS 97 48 49 0 0.00 0.00 0.00 9.50 23.00 42.00fE 52.00 13.77~ 14.94 CCnlrolt 1076 476 599 1 0.00 0.00 2.00 13.50 32.50 44.00! ~ 57.00 18.23! 16.62 A11 1173 524 6481 1 0.00 0.00 2.00 13.00 31.50 43.OOf 57.00 /7.82I 16.51 All CC•.C4 125 66 59 0 0.00 0.00 0.00 7.50 26.00 4D.00 52.00 13.77 15.43 ~ Controls 1656 864 791 1 0.00 0.00 7.00 10.00 25.50 40.00 57.00 14.76 1 15.44 All 1 1781 930 850 1 0.00 0.00 1.00 10.00 26.00 40.00 57.00 14.69 15.44 MOn Cases 14 11 3 0 0.00 0.00 0.00 10.00 19.00 38.00 46.00 13.36 15.82 Controls 580 388 192 0 F 0.00 0.00 0.00 6.00 16.00 31.00 54.00 10.51 12.65 AI1 594 399 . 195 0 0.00 0.00 0.00 6.00 16.00 31.00 1 54.00 10.59 12.73 WOrt1Cn C8SC6 3 57 31 36 0 0.00 1.00 3.00 9.00 32.00 48.00 53.00 17.26 17.53 Controls i 1076 476 599 0.00 0.00 2.00 13.50 32.50 44.00 57.00 18.23 16.62 I AA 1143 507 635 0.00 0.00 2.00 13.00I 32.00 44.00 57.00 18.17 16.66 AIt C9•CS 81 42 39 0 0.00 0.00 3.00 9.50 28.00 45.00 53.00 16.24 16.99 Controls 1656 864 791 1 0.00 0.00 '.00 10.00 25.50 40.00 57.00~ 14.76 15.44 All 1737 906 830 1 0.00 0.00 1.00 10.00 26.00~ 41.00 57.00f 14.83 15.51 ADENOCARCINOMA Men Cases ; 80 52 27 0.00 0.00 0.00 2.50 12.50 25.00 52.00 8.481 12.06 Controls ~ 500 1 388 192 0 0.00 0.00 0.00 6.00 16.00 31.00 54.00 10.51 12.65 A8 ~ 860 ~ 440 218 0.00 0.00 0.00 5.50 16.00( 30.50~ 54.00 10.27 12.58 Women C45C3~ 281 134 146 0.00 0.00 0.00 8.50 22.00 39.00 57.00 13.92 15.03 Controls 1076 476 599 0.00 0.00 2.00 13.50 32.50 44.00~ 57.00 18.23i 16.62 AIl 13571 610 745 2 0.001 0.00 2.00 12.00 30.00 42.50 57.00 17.28 16.37 Nf Cases 361 186 173 2 0.00 0.00 0.00 6.00 20.00 37.00 57.00 iZ 40 14.44 Controls 1656 864 791 1 0.001 0.00 ':.00 10.00 25.50 40.00I 57.00 14.76 15.44 AN 2017 1050 964 3 0.001 0.00 0.00 9.00 24.00 39.00 57.00 14.35. 15.29 OTHER Men C35CS 30 23 7 0 0.00 0.00 1.00 7.00 13.00 16.00 40.00 8.52 8.84 COnV015 580, 388I 192 0 0.00I 0.00 0.00~ 6.00E 16.00 31.00 54.00 10.51 12.65 AN ~ 610 411 199 0 0.00 0. 00~ .00 0.00 6.00 16.00 30.00 54.00 10.40 12.46 W9 tMln C93CII 86 49 37 0 0.00' 0.00 0.00 8.00 21.00 38.00 53.00 '2.84 14.52 CINIUOIS 1076 476 599 1 0.00~ 0.001 2.00 13.50 32.50 44.00 57.00 18.23 16.62 AIl 1162 525 636 1 0.00 0.00~ 2.00 13.00 32.00 43.00 57.00 17.73 16.50 AN C~:Cb 116 COf11r015 ~ 1656 All 1772 72 864 936 ab 791 835 0 1 i 0.00 0.00 0.00. 0.00 0.001 0.00 0.00 7.50 1.00 10.00 1.00 9.50 16.00 25.50 24.00 37.00 40.00 39.00 53.00 57.00 57.00 11.46 13.07 14.76 15.44 14.511 15.29 >7 % OF LIFESPAN IN RURAL AREA OR INTERMEDIATE CITIES MM Ca:CS 76 39 37 0, 0.00 0.00 0.00 2.00 17.00 40.00 52,00 11.69 16.16 i Controls 2251 128 97 0 0.00 0.00 0.00 2.00 16.00 33.00 48.00 10.06 13.58 AN 3011 167 134 I 0. 0.00 0.00 0.00 2.00 16.00 36.00 52.00 10.44 14.19 WOmQn C75C9 ' 237 95 141 1 0.00 0.001 2.00 10.00 28.00 40.00 53.00 15.31 16.16 462 ~vds ~ 191 271 0 ' ~ 4.00 ~ Al 6 99 286 412 1 0.00 0.00 35.00 12.00 44.00 56.00 18.43 17.03 M Cases 313 134 178 1 0.00 0.00 0.00 8.00 27.00 40.00 53.00 14.25 16.18 COfltt01S ~ 687 319 368 0 0.00 0.00 1.00 10.00 29.00 43.00 56.00 16.00 16.60 All 1000 453 546 1 0.00 0.00 1.00 10.00 28.00 43.00 56.00 15.48 16.48 >75'A OF I.IFESPAN IN URBAN AREA Men CaSM 48 41 7 0 0.00 0.00 1.00 7.00 14.00 24.00 36.00 9.34 9.41 Controls I 257 185 1 72 0 0.00 0.00 0.00 6.00 16.00 30.00 54.00 10,68 All 305 226 79 0 0.00 0.00 0.00 6.00 16.00 29.00 54.00 10.43 11.96 WomCn CSSCS 196 109 87 0 0.00 0.00 2.00 1,2.00 25.00 42.00 57.00 15.96 15.73 I Controls 454 A41 _ 650 2031 312 250 337 1 1 0.00 0.00 0.00 2.00 0.001 2.00~ 14.00 13.50 32.00 30.00 42.00 42.00 57.00 57.00 18.34 16.11 17.5115.99 AH Cases 244 150 94 0 0.00 0,001 2.00 9.50 21.00 38.00 57.00 14.15 14.56 I Contfol8 ~ 711 388 322 1 0.00 0.00 0.50 10.00 26.00 39.00 57.00 14.68 14.96 All 955I 5361 416 0.00 0.00 1.00 10.00 24.00 38.00 57.00 14.54, 14.84 ~06 3593408

C S3CU Spouse and other cohabitants, C_umulative exposure (packs/day x years) ALL CENTERS Gwl of .xposuro Non oxposoa 0<S3CU<13 13<S3CU<.25 25<S3CU 4xcludad/Trend Casts I Cantrols OR 1 95% CI OR(2) 95X Cl OR(3) 95% CI OR(4) 95% CI OR(5) 95% CI 252 663 1.00 1.00 1.00 t,oo 1.00 195 432 0.96 ( 0.74- 1.23)1 0.95 ( 0.72- 1.24) 0.96 ( 0.69- 1.32) 0•97 ( 0•75- 1.26) 0.96 ( 0-72• 1.28) 41 86 1.02 ( 0.66- 1.59) 0.91 ( 0.56- 1.46) 0.62 ( 0•35• 1.11) 1.08 ( 0.69- t.67) 0.91 ( 0.55- 1.53) 38 58 1.37 ( 0.85- 2.20)l 1.28 ( 0.78• 2.10) 1.14 { 0.65- 1,99) 1.41 ( 0.88- 2.27) 1.16 ( 0•66- 2.04)1 124 303 0.19 0118 0.20 1 0.18 0.19 ) ALL CENTERS WITH EDUCATIONAL LEVEL AND TYPE OF RESIDENCE oxpoaotl Non 158 487 1.00 1.00 1.00 1.00 1.00 0<S3CU< 1 3 122 287 1.00 ( 0.73• 1.38) 1.00 ( 0.73- i.38) 0.96 ( 0.69- 1.32) 1.00 ( 0.72- 1.38) 1.02 ( 0.71- 1.46) 13<S3CU<25 20 66 0.63 ( 0.36- 1.13) 0.63 ( 0.36- 1.13) 0.62 ( 0.35- 1.11) 0.66 ( 0.37• 1.18) 0.74 { 0.40- 1.37) 25<S3CU 26 48 1.16 ( 0.66- 2.03) 1.16 ( 0.66- 2.03)~ 1.14 ( 0.65- 1.99) 1.17 f 0•67• 2.05) 1.20 ( 0.64- 2.25) .rcludad/Trond 172 450 0.70 0.71 0.68 0.70 0.68 ALL CENTERS WITH DIETARY DATA Non oxposaa 182 406 1.00 1.00 1.00 1•00 1.00 0<S3CU<s1 3 149 276 0.96 ( 0.72- 1.29) 0.94 ( 0.69- 1.27) 0.96 ( 0.67- 1.38) 0.96 ( 0.72. 1.29) 0.96 ( 0.72- 1.28) 13<S3CU<= 2fi 29 58 0.93 ( 0.56- 1.55) 0.96 ( 0.56- 1.63) 0.72 ( 0.39- 1.35) 0.97 ( 0.58. 1.63 ) 0.91 ( 0.55- 1.53) 25<S3Cll 26 41 1.16 ( 0.66- 2,03) 1.23 ( 0.69- 2.17) 1.18 ( 0.63- 2.22) 1.17 ( 0.67- 2.06) 1.16 ( 0.66- 2.04) Excluded/Trsnd 1131 275 0.74 0.74 0.77 0.71 E 0.75 FRANCE Non exposed 0<S3CU<13 13<S3CU<25 25<S3CU Excluded/Trend GERb1ANY 1 34 49 1.00 1 1.00 1,00 1.00 1.00 28 65 0.65 ( 0.33- 1.28) 0.41 ( 0•16- 0.90)1 0.34 ( 0.11- 1.02) 0.62 ( 0.31• 1.23) 0.62 ( 0.31- 1.23) 5 14 0.55 ( 0.17- 1.76) 0.51 ( 0.15- 1.74) 0.20 ( 0.02- 1.84) 0.54 ( 0.17- t•73) 0.51 ( 0.16- 1.66) 5 11 0.74 ( 0.22- 2.46) 0.63 ( 0.17- 2.27)~ 0.97 ( 0.19- 4.88) 0.72 ( 0.22- 2.41) 0.73 ( 0.22- 2.43) 5 12 0.51 0.56 0.60 0.58 ~ 0.60 Non exposea 26 138 1.00 1,00 1.00 1.00 ~ 1.00 0<S3CU<13 21 47 1.59 f, 0.75- 3.37) 1•65 ( 0.72. 3.81) 1.60 ( 0.69- 3.71) 1.79 ( 0.83- 3.85) 1.79 ( 0.83- 3.84) 13<S3CU<=25 1 2 10 0.64 ( 0.12- 3.27) 0.33 ( 0.04- 2.96) 0.41 ( 0.04- 3.73) 0.68 ( 0.13- 3.52) 0.69 ( 0.13- 3.63) 25<S3CU 5 4 3.06 (, 0.71-13.16) 2.61 ( 0.57-11.96) 2.38 ( 0•51-11.11) 3.23 ( 0.74-13.98) 3.19 ( 0.72•14.13) fxcluded/Trend 22j 30 0.30 0.43 0.41 ~ 0.31 [ 0.32 GERMANY2 Non exposed 0<S3CU<13 13<53CU<25 25<S3CU 6'xcluded/Trend GERMANY3 Non exposed 21 31 1.00 1.00 1.00 1.00 1.00 0<S3CU<13 1 15 0.64 ( 0.19- 2.15) 0.64 ( 0.19• 2.22) 0.37 ( 0.09- 1.45) 0.53 ( 0.14- 1.94) 0.51 ( 0.14- 1.81) 25<S3CU 0 1 0.00 ( 0.00-99.99) 0.00 ( 0.00-99.99) 0.00 (, 0.00-99.99) 0.00 ( 0.00-99.99) 0.00 t, 0.00-99.99) c"xcluded/Trendj 3i 5 0.37 0.38 0.15 0.39 j 0.28 eXp03Qtl 14 103 1.00 1.00 1.00 1.00 s 0<$3CU<13 16 72 1•02 ( 0.44- 2.39) 1.30 ( 0.54- 3.15) 1.20 ( 0.48- 2.96) 1.29 ( 0.52• 3.17)~ 13<$3CU<•25 14 0.24 ( 0.03- 2.07) 0.30 ( 0.03- 2.65) 0.28 ( 0.03- 2.48) 0.29 ( 0.03- 2.54)1 25<S3CU 3 10 1,10 ( 0.25- 4.91) 1.52 ( 0•33• 7.03) 1.38 ( 0.30- 6.40) 1.27 (, 0.28- 5.79) ) Cluded/Trend 6 221 0.68 E 0.81 0.81 0.66 € 10 95 1,0o I 1.00 1.00 : 1.00 0<S3CUe.13 5 50 0.35 { 0.10• 1.28) 0.25 ( 0.06- 1.Ot) 0.17 ( 0.03- ?.04) 0.33 ( 0.09• 1.23) ~ 13<S3CUc25 0 11 .00 { 0.00-99.9 0 9) 0.00 ( 0.00-99.99) 0.00 ( 0.00-99.99) 0.00 { 0.00-99.99) 25<83CU 2 6 1.02 ( 0.16- 6.48) ! 1.12 ( 0.17- 7.50) 0.86 ( 0.05-13.53) 1.07 ( 0.16- 6.97) Excluded/Trand 2 111 0.86 0.91 ) 0.97 0. 82 ~ ITALY 3 ~ Non exposed 3 22 1,00 1.00 1•00 : 1.00 1.00 0<S3CU<13 6 6 7.45 ( 1.16-47,94) 6.31 ( 0.88-45.53) 3.01 ( 0.31-28.99) 6.14 ( 0.92-41.22) 7.69 ( 0.92-64.31) 13<S3CU<26 3 5 3.02 ( 0.40-22.65) 3.85 ( 0.43-34.80) 2.83 ( 0.23-35.16) 2.94 ( 0.39•22.27) 5.80 ( 0.54-62.22) 25<S3CU 1 4.71 ( 0.19-115.2) 4.26 ( 0.17-107.9) 1.63 ( 0•06-45.61) 5•21 ( 0.20-134•3) 4.25 ( 0.15-123.8) ~°kc1 uded/Trend 3 16 0.49 0.53 ) 0.80 0.42 j 0.57 PORTUGALI Non exposed 20 17 1.00 1.00 0<S3CU<13 16 16 1.03 { 0.36• 2.94) 1.09 ( 0.37• 3.24) 13<S3CU<25 6 2 4.65 ( 0.71-30.58) 4.70 ( 0.72-30.76) 25<S3CU 5 0 99.99 ( 0.00-99.99) 99.99 ( 0,00-99.99) Exc2uded/Trond 2 4 0.01 I 0.01 PORTUGAL2 Non exposed 13 30 1.00 1.00 1.00 0<S3CU<13 7 17 1.37 ( 0.39- 4.78) 0.95 { 0.23- 3.98) 1.21 { 0.33- 4.46) 13<S3CU<=25 01 99.99 ( 0•00-99•99) 99.9s ( 0.00-99.991 99.99 ( 0,00•99.99> 25<S3CU 1 1 9.06 ( 0.59-138.8) 7.82 { 0.46-132.8) 9.75 ( 0,65-147.0) ~'rcludod/Trend ~ 1 5 0.02 0.01 0.02 SPAIN Non exposed 0<S3CU<13 13<S3CUu25 25<S3CU €xcluded/Trend 19 35 1.00 1.00 1.00 1.00 1.00 20 50 0.68 ( 0.30• 1.51) 0.78 1 0.32• 1.87)~ 0.74 ( 0.30• 1.87) 0.68 ( 0.30- 1.56) 0.66 { 0.29- 1.50) 6 tBf 0.55 ( 0.18- 1.69) 0.65 ( 0.20- 2.12) 0.64 ( 0.19- 2.15) 0.62 ( 0.20- 1•95) 0.64 { 0.17- 1.7!) 61 16 0.69 ( 0.22• 2.19) 0.73 { 0.22- 2.46)1 0.73 ( 0.21- 2.55) 0.69 ( 0•22• 2.20)~ 0.73 ( 0.23- 2.37) 20 39 0.58 0.50 j 0.51 0.60 0.66 SWEDEN Non exposed 32 52 1.00 1.00 1.00 1.00 t 0<S3CU<13 27 54 095 ( 0.49- 1.86) . 0.94 ( 0.48• 1.84) 0.96 ( 0.49• 1.89) 0.96 ( 0.49- 1.88)j 13<S3CU<25 5 3 5.25) 3.20 ( 0.67-1 4.01 ( 0.80-20.09) 3.34 { 0.70-15•89) 3.08 ( 0.64-14•84j $5<S,7CU l 3 1 5.96 ( 0.56-63.64) 6.17 ( 0.55-68.69) 6.13 ( 0.58-65.20) 7.05 ( 0.65-76.72) Fxcluded/Trend 3 2 0.06 t 0.05 ~ 0.05 0.05 UNITED KINGDOM 6xc1 uded/Trend l 261 140 (1) Modol indudo sox, eonter, sex•center and age (2) Mocbf Irtciude sox, center, sex'center, age and proportion of residential type in the last 35 yrs (REUP) (3) Mo8e1 inolude sex, eenter, sax•centor, age, proportwn of residential type in the last 35 yrs (REUP) and educational level (EDUC) (4) Model inGude sox, centar, sex'conter, age and duration of exposure to liSt A agents (OCLAY) --- ------`---- 2-063593427 LL11/nd.nLSe.eludeienr_e-i~en ..t.- nao c

C _S 1 TS Spouse, Trme since last ETS exposure (years) MEN ONLY LnvN ot .x osuro Cases %p088tl 118 6 Non e 16< SITS 2< S17S<15 5 Excluded/Trend 0 0<S17S<2 12 WOMEN ONLY Non 1%poSaa 187 - ~ 15< SITS 100 2< S1TS<•15 106 0<S1TS<2 € 97 Excludld/Trendl 19 POPULATION BASED STUDIES Controls OR(1) 95% CI OR(2) 95Y. CI OR(3) 95'/. CI ( OR(4) 95•/. Cl OR(5) 95% CI 462 1.00 1.00 1.00 1.00 1.00 1 9 1.98 ( 0.60- 6.49) 1.87 ( 0.52- 6.76) 4.38 ( 0.58-33.28) 2.03 ( 0.61- 6.73) 2.12 ( 0.57• 7.81) 20 1.05 ( 0.35- 3.13) 1.26 ( 0.40- 3.96) 0.89 ( 0.20- 3.95) 1.01 ( 0.34- 3.05) 0.82 ( 0.24- 2.79) 39 1.55 ( 0.70- 3.42) 1.60 ( 0.69- 3.71) 0.84 ( 0.27- 2.64) 1.54 ( 0.69- 3.41) 1.86 ( 0.76- 4.54) f 0.31 ~ 0.36 0.36 0.33 0.31 376 1.00 1.00 1.00 1.00 1.00 999 1.07 { 0.78- 1.46) 1.13 ( 0.81- 1.57) 1.11 ( 0.76- 1.63) 1.08 ( 0.79• 1.49) 1.13 ( 0.79- 1.60) 221 1.12 ( 0.83- 1.52) 1.09 ( 0.79- 1.50) 1.00 ( 0.69- 1•45) 1.13 ( 0.83- 1.53) 1.02 ( 0.72- 1.45) 193 1.03 { 0.75• 1.41) 0.97 ( 0.69- 1.36) 0.99 ( 0.68- 1.46) 1.07 ( 0.78- 1.47) 0.94 ( 0.65- 1.36) 22 0.05 0.05 0 0.08 0.07 0.05 Non 0%pOSmtl 186 577- 1.00 1.00 ( t.00 1.00 1.00 ib< SITS 67 113 1.11 ( 0.75- 1.64) 1.12 ( 0.75- 1.68) 1.09 ( 0.68- 1.75) 1.13 ( 0.77- i.68) 1.25 ( 0.81- 7.93) 2< 81TS<15 60 1 139 0.95 ( 0.65- 1.40) 0.97 ( 0.66- 1.44) 0.97 ( 0.62- 1.52) 0.98 ( 0.66• 1•45) 0.91 ( 0.59- 1.42) 0<S1TS<2 61 117 1.19 ( 0.80- 1.77) l 1.24 ( 1 0.83- 1.85) 1.23 ( 0.78- 1.95) 1.21 ( 0.81- 1.81) 1.39 ( 0.88• 2.19) Excludad/Trand 4 4! 0.18 ~ 0.19 0.27 ~ 0.18 0.20 1 HOSPITAL BASED STUDIES Non BxpoSetl 11 201 1.00 1.00 1.00 1.00 1•00 15< SITS 33 65 1.11 ( 0.66- 1.88) 1.20 ( 0.67- 2.16) 1.35 ( 0.65- 2.78) 1•10 ( 0.64• 1.87) 1.02 ( 0.56- 1.86) 2< S17S<15 45 70 1.60 ( 0.98- 2.61) 1.39 ( 0.81- 2.41) 1.14 ( 0.59- 2.19) 1•58 ( 0.96- 2.60) 1.19 ( 0.68- 2.09) 0<S1TS<2 ~ 42 97 0.90 ( 0.56• 1.45) 0.64 ( 0.36- 1.15) 0.56 ( 0.28- 1.12) 0.94 ( 0.58- 1.51) 0.59 ( 0.33- 1.06) Ercludld/Trend 6'JiTHOUT OCCASIONAL SMO KERS 15 19 0.16 0.18 0.21 0.21 0.10 Non exposea 2251 593 1.00 1.00 1.00 ?•00 f 1.00 ~ 15< SITS ?81 148 1.14 ( 0.80- 1.63)1 1.18 ( 0.81- 1.73) 1.03 ( 0.67- t.56) 1.15 ( 0.80- 1.65) 1.20 ( 0.81• 1.79) / 2< S1T8<.15 1 1 174 1.15 ( 0.82- ].62) 1.11 ( 0.78- 1.60) 0.94 ( 0.63- 1.41) 1.15 ( 0.81- 1.62) 1.07 ( 0.72- 9.58) i 0<S17S<2 85 168 1,11 ( 0.79• 1.57)~ 1.04 ( 0.71- 1.51) 0.96 ( 0.64• 1.44) 1.15 ( 0.82• 1.63) 0.92 ( 0.61- 1.38) Excludad/Trend l 17! 21 0,03 0.03 1 0.07 0.04 ( 0.03 AGE <55 YEARS Non expoaso 94 215 1.00 1.00 1.00 I 1.00 1.00 t5< SITS 18 17 1.84 ( 0.86- 3.93) 1.89 ( 0.84- 4.24) 2.34 ( 0.75- 7.28) 1.98 ( 0.92- 4.28) 2.32 ( 0.99- 5.45 ) 2< S1T8<15 17 51 0.68 ( 0.36- 1.31) 0.69 ( 0.34- 1.39 ) 0.78 ( 0.34- 1.75) 0.65 ( 0.33- 1.26) 0.65 ( 0.31- 1.36)  S17S< 0<2 34~ 73~ 1.00 ( 0.58- 1.70) 1.07 ( 0.59- 1 .ss) 1.20 ( 0.62- 2.32) 0.98 ( 0.57- 1.68) 1.07 (, 0.57- 2.01) Sxcludld/Trend 2 5 0.75 0.77 ~ 0. 7> 0.69 0.73 AGE 55•W YEARS Non exposea 15< SITS 2< S17S<15 0<S1TS<•2 Excl uc'ed/Trlnd AGE 65+ YEARS 98 309 1.00 1.00 1.00 1.00 1.00 26 65 0.94 ( 0.52• 1.67) 0.89 ( 0.49- 1.63) 0.72 ( 0.37• 1.43)I 0.95 ( 0.53- 1.71) 0.81 ( 0.42- 1•57) ~ 40 85 1.33 ( 0.80- 2.21) 1.09 ( 0.64• 1•86) 0.78 ( 0.42- 1.42) 1.22 ( 0.72- 2.06) 1.13 ( 0.63- 2.03) € 39 84 1.15 ( 0.69- 1.92) 0.98 ( 0.57- 1.69)~ 0.83 ( 0.44- 1.55)1 1.22 ( 0.72- 2.04) 1•06 ( 0.58- 1.94) i 9 0.09 0.10 0.10 0•f0 0.08 Non Cxposetl 113, '14 1,00 1•00 1•00 1.00 1.00 15< SITS 1 62 126 1•16 ( 0.76- 1•76) 1.31 ( 0.84- 2.04) 1.33 ( 0.79- 2 26)i 1.17 ( 0.77• 1.79) 1.28 ( 0.80- 2.02)1 2< S1TS<15 ( 541 105 1.36 ( 0.87- 2.12) 1.44 ( 0.90- 2.29) 1.41 ( 0.82- 2.43)( 1.45 ( 0.92• 2.27) 1.31 ( 0.79- 2.16) 0<S1T8<2 ; 36i 75 1.10 ( 0.66• 1.81) 1.05 ( 0.62- 1.78) 1.12 ( 0.61- 2.06)~ 1.16 ( 0.70- 1.92) 1.02 0.59- 1.79) ~'xcludld/Trlnd~ 1 `0 9~ 0.02 0.03 0.04 0.03 0.02 HISTOLOGICALLY CONFIRMED DIAGNOSIS Non exposea 296 838 1.00 1.00 1.00 ; 1.00 1.00 15e SITS 101 208 1.09 ( 0.81- 1.49) 1.15 ( 0.84- 1.59) 1.13 { 0.78- 1.65) 1.12 ( 0.82- 1.52) 1.18 ( 0.84- 1.65) 2< S1TS< 1b 106 241 1.13 ( 0.84- ?.51) 1.11 ( 0.81- 1.51) 1.04 ( 0.73• 1.48) ~ 1.12 ( 0.83- 1.52) 1.06 ( 0.76- 1.49) 0< S1 TS< 2 1051 232 1.05 1 0,78• 1.42) 1.01 ( 0.73- 1.40) 1.04 ( 0.72- 1.49) 1.09 ( 0•81• 1.47) 1 .05 ( 0.75- 1.48) .xcluded/Trand 191 23 0.04 ( 0.04 0.05 0.04 0.03 SQUAMOUS CELL CARCINOMA Non exposaa 15< SITS 2< SiTS<15 0<SiTS<2 £xcluded/Trend SMALL CELL CARCINOMA Non exposw 15< SITS 2< S1TS<.15 0<S17S<2 Excluded/Trend ADENOCARCINOMA Non exposed 15< SITS 2< SiTS<15 0<SiTS<2 €Xcluded/Trend OTHER 31 11 12 14 2 159 51 56 57 10 638 208 241 232 23 1.00 1.35 1.17 1.07 0.39 1,00 1.02 1.17 2.06 0.01 8381 1.00 208 1.02 241 1.09 232 1.01 23 0.17 Non exposed ) 56) 838) 1.00 15< SITS 1 191 2081 1.14 2< S1TS<.15 20 "41( 1.12 0<SiTS<2 ~ 16 2321 0.87 fxcluded/Trand! 4~ 23! 0.45 E 1.00 ! 1.00 1.00 1.00 ( 0•73• 2.49) 1.32 ( 0.70- 2.49)! 1.29 ( 0•63• 2.66) 1.37 ( 0.74- 2.53) 1.<^2 0.62- 2.40) ( 0.63- 2•17) 0.87 ( 0.44- 1.70)f 0.79 ( 0.37- 1.65) 1.12 ( 0.60• 2.09) 1.00 0.50- 1.98) (, 0,58• 1.98) 0.84 ( 0.41- 1.72) 0.91 ( 0.42- 1.98) 1.01 ( 0.54- 1.89) 0.67 0.30- 1.50) 0.38 ~ 0.48 ~ 0.39 0.38 ~ ~ 1.00 1.00 1.00 1.00 P ~ ( 0.46- 2.25) 0.96 ( 0.42- 2.20) 0.98 ( 0.40- 2.40) 1.02 ( 0.46- 2.27) 0.96 ( 0.42- 2.21) ~ ~y ( 0.55- 2.46) 1.22 ( 0.57- 2.61) 1.17 ( 0 52- 2 65) 11 ( 1 51- 0 41) 2 1 15 ( 0 53- 2 51) " J ( 0.99- 4.30) 1.91 ( 0.89- 4.11) 2.27 ( . . 1.02- 5.08) . 2.16 ( • 1•02- . 4.54) . 2•04 ( . . 0.95- 4.40) '••t~ tt) 0.01 0.01 0.01 0.01 !~ ;1J 1 1.00 1.00 1.00 1•00 ( 0.69- 1.51) 1.09 ( 0.72- 1.65) 1.12 ( 0.68- 1.83) 1.06 ( 0.71- 1.57) 1 1.12 0.73- 1.71) ( 0.75- 1.59) 1.12 ( 0.75- 1.66) 1.05 ( 0.66- 1.65) 1.12 ( 0.77- 1.64) I 1.04 0.69- 1.59)! ( 0.70- 1.47) 0.97 ( 0.65- 1.47) 0.97 ( 0.61- 1.54) 1.07 ( 0.73- 1.56) 1 0.99 0.65- 1.52)~ 0.16 0.22 0.21 0.16 1.00 1.00 i 1.00 1.00 ( 0.63• 2.07) 1.26 ( 0.67- 2.37) 1.15 { 0.55- 2.41)~ 1.16 ( 0.63- 2.11) 1.42 ( 0.74- 2.74) ( 0.62- 2.00) 1.21 ( 0.66- 2.22) 1.11 ( 0.55- 2.21) 1.11 ( 0.62• 2.02) 1.10 ( 0.56- 2.17) ( 0.47- 1.61) 0.96 ( 0.50- 1.85) 0.88 ( 0.42- 1.84) 0.92 ( 0.50• 1.72) 1.14 ( 0.58- 2.23) 0.45 0.47 I 0.44 0.45 >7551 OF LIFESPAN IN RURAL AREA OR INTERMEDIATE CITIES Non exposed ( 122 321 1.00 1.00 1.00 1.00 1.00 15< SITS 40 911 1.01 ( 0.62• t.65) 1.01 ( 0.62- 1.65) 0.83 ( 0.47- 1.49) 1.01 ( 0.62- 1.66) 0.93 ( 0.56- 1.56) 2< S1T5<15 45 89 1.27 r, 2.03) 0.79. 1.27 ( 0.79- 2.03) 0.90 ( 0•52• 1.55) 1.21 ( 0.75- 1.95) 1.09 ( 0.66- 1.79) g 0<S1TS<. 6 0 .39 ( .86- 2.27) 1.39 ( 0.86• 2.27) 1.35 ( 0.78- 2.34) 1.43 ( 0.87• 2.34) 1.20 ( 0.72- 1.99) Pxcluded/Trtnd 3 4 0.06 0.06 0.11 0.09 0.08 >75% OF LtFESPAN IN UROAN AREA Non @xpoSla 103 356 1,00 1.00 ~ 1.00 1.00 1.00 95c S1TS 51 94 1.30 ( 0.82- 2.08) 7.30 ( 0.82- 2.06) 1.44 ( 0.83- 2.50) 1.29 ( 0.80- 2.06) 1.62 ( 0.95- 2.76) 2< 81TS<.15 49 ?22 1.17 ( 0.74- 1.86) 1.17 ( 0.74- 7.86) 1.31 ( 0.78- 2.21) 1.18 ( 0.74• 1.87j 1.32 ; 0.76- 2.31) 0<$1T5<2 l 80~ t25 0.65 ( 0.39- 1.08) 0.65 ( 0.39- 1.08 ) 0.65 ( 0.36- 1.16) 0.65 ( 0.39- 1.09) 0.68 ( 0.38- i.22)~ ExCltidld/Trend /1 1 14 0.62 0.62 0.63 ~ 0.65 ( 0.58 (1) MOdO! klcfude sex, canter, sex'center and age (2) Model Indude sex, center, sex'cen(er, age and proport On of residenGa) type in the last 35 yrs (REUP) (3) Model Hsdude sex, center. sex'cgnter, age, proportion of residenGal type in the Iast 35 yrs (REUP) and educational level (EDUC) (4) Mode) Indude sex, eenler, aex'oenter, age and duration of exposure to list A agents (OCLAY) (5) Model fndude sex, center, sex'cenler, age and frequency consumption of vegetables (VEGE)

D_S3UD Spouse and other cohabitants, Duration (years) (non overiapping) ALL CENTERS Levol of exaosun Non OXpC30d 0<S3U0<34 34<S3UD<42 42<S3UD Cases Control3 OR(1) 96% C1 260 717 1.00 249 574 1.01 ( 0.80• 1.28) 68 123 1.37 ( 0.95- 1.98) 46 90 1.15 ( 0.75- 1.76) ExCludad/Trtndf 27 38 0.20 ALL CENTERS WiTH EDUCATIONAL LEVEL AND TYPE OF RESIDENCE Non exposed 166 0<S31.10<34 163 34<S3UD<42 49 42<S3UD 32 Excluded/Trend 88 ALL CENTERS WITH DIETARY DATA 1.00 1,03 ( 0.77- 1.37) 1.32 ( 0•85- 2,04) 1.02 ( 0.62- 1.70) 0.66 OR12) 95% Cl O 3) 9S% Cl ( OR(4 96% CI I OR(.5 95x Cl 1.00 1.00 t.oo 1•00 1.00 ( 0.78- 1.29) 1.00 ( 0.75• 1.34) 1.01 ( 0.80- 1.28) 1,03 ( 0.79- 1.34)1 1.29 ( 0.87- 1.91) 1.29 ( 0.83- 2.00) 1.42 ( 0.98. 2.06) 1.41 ( 0.91- 2.17) 1.15 ( 0.73- 1.80) 0.97 ( 0.58• 1.61) 1 1.26 ( 0.81- 1.94) 1.01 ( 0.62- ~ 1.63) 1 0.19 0.28 0.19 1 0.22 1.00 1.00 ( 1.00 1.00 1.04 ( 0.78- 1.38) 1 .00 ( 0.75- 1.34) 1.01 ( 0,75- 1.36) 1.07 ( 0.78- 1.47) 1.33 ( 0.86• 2.05) 1.29 ( 0.83- 2.00) 1.35 ( 0.87- 2.09) 1.57 ( 0.97• 2.54) 1.03 ( 0.62- 1.71) 0.97 ( 0•58- 1.61) 1.09 ( 0.65• 1,81) 0.99 (, 0.58• 1.72) 0.64 0.85 E 0.65 0.69 ~ Non exposed 200 460 1.00 1.00 1.00 1•OO 1.00 0<S3UD<•34 194 397 1.03 ( 0.79- 1.34) 1.03 ( 0.78- 1.35) 1.02 ( 0,74- 1.40) 1.02 ( 0.78- 1.33 ) 1.03 ( 0.79- 1.34) 34<S3UD<.42 fi0 1 8 1.42 ( 0.92- 2,18) 1.45 (, 0.93- 2.27) 1.55 ( 0.96- 2.52) 1.44 ( 0.94- 2,23) 1.41 ( 0.91- 2.77) 42<S3UD 36 71 1.03 ( 0.63- 1.66) 1.07 ( 0.65- 1.74) 0.93 ( 0.54- 1.62) 1.10 ( 0.68- 1.78) 1.01 ( 0.62- 1.63) txcluded/Trond 29 47 0.35 0.36 0.50 1 0.33 0.38 ~ OXp030tl Non 34 49 1.00 1.00 1.00 1.00 1.00 p<S3UD<34 i 33 76 0.64 ( 0.33- 1.22) 0.44 ( 0.20- 0.95) 0.41 ( 0,15- 1.10) 0.60 ( 0.31- 1.16) 0.61 ( 0.32- 1.18) 34<S3U0<.42 3 4 0.33 ( 0.08- 1.29) 0.16 f, 0.03- 0.833 0.20 ( 0.03- 1.26) 0.32 ( 0.08- 1.27) 0.31 ( 0.08- 1.25) 42<S3UD 7 11 0.98 ( 0.32- 3.02) 0.69 ( 0.20- 2.44) 0.30 ( 0.04- c^.16) 1.07 ( 0.34- 3.45) 0.93 ( D.30• 2.89) 5'xc1 udad/Trand f 0 f 0.26 0.13 0.10 0.22 0.22 GERMANYI Non exposotl 0<S3UD<•34 34<S3UD<42 42<S3U0 fxcluded/Trend GERMANY2 26 138 1.00 t,00 1•00 1.00 1.00 34 73 1.96 ( 1.01- 3.79) 2,14 ( 1.03- 4.44) 2.09 { 1.00- 4.34) ~ 2.05 ( 1.04- 4.06) 2.24 ( 1.13- 4.42) 10 8 4.53 ( 1.52•13.46) ~ 6.58 ( 1.81-23.89) i 6.45 ( 1.74•23.92) f 4.72 ( 1.57•14.18) 4,96 ( 1.62-15.22) ~ 3 9 0.71 f 0.17- 2.98) 0,67 ( 0.15- 2,96)~ 0.63 ( 0.14- 2.81)~ 0.73 ( 0.17- 3.11) 0.66 ( 0.15• 2.85) ! 3 1 0.06 } 0,08 0.11 0.08 0.07 Non exposed ~ 60 0<S3UD<34 49 34<S3U0<42 19 42<S3UD 11 .xcludad/Trend 3 91 1.00 1.00 ~ 1.00 1.oa 1.00 56 0.93 ( 0.52- 1.64) 0,67 ( 0,49- 1,55) 0.82 ( 0.46- 1.47) 0.92 ( ss 0.52- 1.63)~ 0•91 ( 0.51- 1.61) 7 2.75 (, 1.03- 7.35) 2.69 ( 1.00- 7.24) 2.41 ( .89• 6.55) 0 2.75 ( 1.03• 7,34) 2.63 ( 0.98- 7,05)+' 8! 1.45 ( 0.50- 4.22) 1.36 ( 0.47- 3.96) 1.34 ( 0.45- 3.98) 1.44 ( 0.49- 4.18) 1.46 ( 0.50- 4•25)f 1 o,f4 0.19 0.27 o.rs 1 0.14 €t GERMANY3 Non exposed 0<S31.10<34 21 31 1.00 1.00 1.00 1.00 1.00 6 17 0.50 ( 0.15• 1.65) 0.48 { 0.14- 1.62) 1 0.26 ( 0.07- 1.01) 0.36 { 0.10- 1.37)I 0.40 ( 0.11- 1.41) 34<S3UD<.42 1 T 2 0.63 ( 0.05- 8.20) 0.58 (, 0.04- 6,27) 0.95 ( 0.05-17.75) 0.61 ( 0.05- 8.02) 0.73 ( 0.05-10.49) 42<S3UD 2 ~ 2 1•92 ( 0.22-17.17) 1.80 ( 0.19-17.01) ~ 0.89 ( 0•09• 9.19) 2.52 ( 0.27-23.56) 1.23 ( 0.13-11.42) Szcluded/Trend 0 0.78 0.73 0.43 0.82 0.58 ITALY 1 Non exp03etl Q<S3U0<34 34<S3U0<e42 42<S3U0 14 103 1,00 1.00 1. 00 1.00 20 86 1.07 ( 0.48- 2.40) 1,36 ( 0.58- 3.19)1 1.32 ( 0.55- 3.16) 1,38 ( 0.59- 3.27) ~ 2 21 0.37 ( 0.07• 1.88) 0.47 ( 0.09- 2.47) 0.43 ( 0.08- 2.25)~ 0.44 ( 0.08- 2•27) 3 10 1.30 ( 0.29- 5.91) 1.62 ( 0.34- 7.65) 1 1.51 ( 0.32- 7.24) 1.77 ( 0.37- 8,83)I ~xcludad/Trand 1 ' 0.66 ( 0.72 0.71 1 0.68 ~ ITALY 2 Non axposod 10 95 1.00 7,00 1,00 1.00 <S3UD<34 0 5 481 0.40 ( 0.11- 1.45) 0.25 ( 0.06- 1.09) 0.18 ( 0.03- 1.27) 0.37 ( 0.10- 1.34) 3q<S3UD<42 2 171 0.31 ( 0.05• 1.81) 0.34 ( 0.05- 2.10) 0.37 ( 0.05- 3.10) 0.31 ( 0.05- 1.79) 42<S3UD ^ 6~ 0.55 ( 0.05- 6.00) 0.41 ( 0.04- 4.59) 0.00 j 0.00-99.99)~ 0.59 ( 0.05- '0.55) Ezcludad/Trand 1 +' 0.17 0.17 0.11 0.16 ITALY 3 Non ®xpo3®tl 3 22 1.00 1.0o t. oo ,.o0 1.00 0<83U0<.34 7 16 3.41 ( 0.64-18.22) 3•00 ( 0.55-16.51) 1 . 42 ( 0.20-10.17) 2.89 1 0.50-16.52) 9.90 ( 1.18-82•92) 34<S3UD<.42 ~ 1 5 1.10 ( 0.08-15.12) 0.96 ( 0.07-13.51) 1.55 ( 0.07•32.80)( 1.05 ( 0,08-14.67) 1.68 ( 0.09-32.45) q2<$3UD ; 4 61 3.69 ( 0.48-28.20) 4.14 ( 0.48•35.41) 1.89 ( 0.19-19.11) 3.78 ( 0.48-29.61) 3.04 ( 0.28-32.61) €xCludadJTrsnd ~ ` 1 2 0.34 D-36 ~ 0.39 0.34 0.37 ( PORTUGAL 1 Non exposed 0<S3U0<34 34<S3UD<.42 42<S3UD e"xcluded/Trend PORTUGAL2 1.00 1.17 ( 0.42- 3.21) 9.88 ( 0.98•99.56) 5.42 ( 0.35-83.51) 0,06 1.00 1.22 ( 0.43- 3.49) 10.63 ( 1.05-108-0) 5,88 ( 0,38•91.28) 0.07 Non o%pasetl 30 1.00 1•00 L 00 1 0<S3U0<a34 19 1.62 (, 0.53- 4.98) 1.25 1 0.36- 4.32) 1.49 ( 0.47- 4.71) 34<S3U0<42 i 6 3 6,64 ( 1,23-35,77) 4.69 ( 0.74•29.90) { 7.37 ( 1.33-40.76} 42<S3U0 ~ 1 ~ 10.42 ( 0.60-99.99) 10.60 i 0.45-99.99) 11.29 ( 0.67-99.99) EXC1Udad/Trand 0 l 0.02 0.03 0.02 SPAIN oxposod Non 0<S3UD<•34 19 35 1.00 100 . 1.00 1.00 1.00 25 57 0.73 ( 0.33- 1.58) .80 { 0 0.34• 1.85) 0.81 ( 0.34- ?,93) 0.74 { 0.33- 1.64) 0.69 ( 0.31- 1.53) ~ 34<$3UD<42 a 26 0.54 ( 0.19- 1.55) 0.60 ( 0.20- 1.82)f 0.51 ( 0.16- 1.65) 0.54 ( 0.19- 1.55) 0.56 ( 0.19- 1.62) 42<S3UD l 18 0.37 ( 0.10- 1.30) 0.40 ( 0.10- 1•58)~ 0.36 ( 0.09- 1.43) 1 0.42 ( 0.12- 1.50)~ 0.39 ( 0.11• 1.40) ~ cluded/Trend €x 231 0•fo ~ 0.08 , 0.08 o.fo t 0.12 Non exposed 32 52 1.00 1.00 1,00 ( 1.00 Q<$3UD<34 31 J2 1.09 ( 0.57- 2.10) 1.08 ( 0.56- 2.09) 1,11 ( 0.57- 2.,4) 1.09 ( 0.56- 2.11) 34<g3UD<.q2 1 3 5~ 1.23 ( 0.26- 5.80) 1.37 ( 0.28- 6.71) ~ 1.25 ( 0.26- 5.91) 1.17 ( 0.24- 5.56) 42<S3UD 3 3 1.54 ( 0.27- 8.67) 1.37 ( 0.24- 7.84) 1.64 ( 0•29- 9.21) 1.57 ( 0.27• 9.02) ExCludad/Trandl ° o ! 0.62 0.64 ! 0.57 0.63 UNITED KINGDOM 3 Non exposed 0<S3UD<34 ~ 10 34<S3U0<42 6 42<S3U0 fxcludad/Trendi 0 1.00 1-00 1.00 1 1.00 1.28 ( 0,44- 3.78) 1•18 ( 0.39- 3.55) 1.15 ( 0•38• 3•50)( 1.39 ( 0.47- 4.10) 3.04 ( 0.83•11.13) 2.82 ( 0.76-10.44) 3.28 ( 0.92•11•67)I 3.19 { 0.90-11.36) 0.87 ( 0•15- 4.99) 0.76 ( 0.13- 4.52) 0.98 ( 0•18- 5,41)' 0.93 ( 0•17- 5.03) 0.33 i 0.43 0.29 E 0.30 (1) Modol inelude sex, eanter, sex'conter and age (2) MQ4C( ffiG(HCIe SQX, G6rtfOf, iOX'wnter, ege and proportion of ~asitieMial type rn the tast 35 yrs (REUP) (3) Modal incjude sex, canter, 3ex'untar, age, proportion of residential type in the last 35 yrs (REUP) and educatlonat Ievel (EDUC) (4) Model Includa sex, center, sex•centar. aga and duration of exposwe to list A agents (OCLAY) ~~y °zJ63593423

E _VvutV Workplace, ever exposed ALL CENTERS Lwd of uc Urc Non exposed E%pOSe d ases Control5 ORN 95% CI OR(2) 95% CI ! OR 3 9S ti CI ! OR(4 95% C! b' OR(5 95% Cr I 276 687 1.00 1.00 1.00 1.00 1.00 374 855 1.17 ( 0.94• 1.45) 1.13 ( 0.90- 1.41) 1.08 ( 0.83• 1.39) 1.16 ( 0.93- 1.44) 1.08 ( 0.85- 1.38) r"xcluded/Trond 0 ~ 0 1 ALL CENTERS WITH EDUCATIONAL LEYEL AND TYPE OF RESIDENCE Non exposed 195 523 1.00 1.00 Exposed 236 637 1.06 ( 0.82- 1.36) 1.05 ( 0.81- 1.35) 1.00 1.00 1.00 1.08 ( 0.83- 1.39) 1.02 ( 0.79- 1.32) 1.01 1 0.77- t.33) s'xcluded/Trondl 67 178 ~ ALL CENTERS WITH DIETARY DATA Non 0%poseG 196 408 Exposed 306 628 1.00 1.00 1.00 1.00 t.00 1 1.08 ( 0.85- 1.38) 1.07 ( 0.83- 1.38) 1.02 ( 0.78• 1.35) 1.06 ( 0.83- 1.35) ~ 1.08 ( 0.85- 1.38) Exoluded/Trend 7 20 FRANCE Non exposed Exposed 38 78 1.00 1.00 1.00 1.00 1.00 39 73 1.07 ( 0.61- 1.87) 0.97 ( 0.51- 1.82) 1.09 ( 0.48- 2.49) 1.05 ( 0.60- 1.86) 1.06 ( 0.60- 1.86)1 l 1 1 Excluded/Trond 0 0 j GERMANYI Non exposed 19 46 1.00 1.00 1.00 1.00 1.00 Exposed 7 183 1.00 ( 0.52- 1.94) 1.07 ( 0.52- 2.21)1 1.06 ( 0.51- 2.21) 0.96 ( 0.48- 1.90) 1.16 (, 0.58- 2.31)~ €xcluded/Trend GERMANY2 I Non exposed 64 62 1.00 1.00 1.00 1.00 1.00 Exposed 78 101 0.86 ( 0.53• 1.39) 0•91 1 0.56• 1.49) 0.91 ( 0.55- 1.50) 0.87 ( 0.53- 1.40) 0.89 ( 0.55- 1•44) Non exposed 13 28 1.00 1.00 1.00 1.00 1.00 Exposed ' 18 24 1.63 ( 0.58• 4.56) 1.66 ( 0.59- 4.72) 1.54 ( 0.51- 4.60) 1.10 ( 0.37- 3.31) 1.77 ( 0.61- 5.13) €xcluded/Trendl ' 0~ 0 1 Non exposs0 22 108 1.00 1.00 1.00 1.00 ExposOd 18 113 1.07 ( 0.49- 2.30) 1.30 ( 0.58- 2.90) 1.23 ( 0.54- 2.79) 1.05 ( 0.47- 2.32)~ 6xcluded/Trend 0 01 i ~ Non exposed Exposed 19 30 Excluded/Trendl 0 PORTUGALY Non OXpOS9d Exposed Bxcluded/Trand~ SP6JN 23 10 01 24 15 1.00 2.81 ( 1.05• 7.54)i 39 14 1.00 1.43 ( 0.50- 4.06) 1.00 1.30 ( 0.42- 3.96) € 1.00 j 2.98 ( 1.11- 8.00) 1.00 ~ 1.60 ( 0.55- 4.62) ~ Non Q%pOSOtl 32 84 1.00 00 1.00 1.00 1. 1.00 ~ 39 ~ Exposed 75 1.38 ( 0.76- 2.50) 1.36 ( 0.74- 2.52) 1.39 ( 0.74- 2.60)~ 1.37 ( 0.75- 2.48) 1.59 ( 0.86- 2.94) Pxeluded/Trend o~ 0 ~ ~ SWEDEN Non Cxposod 8 21 1.00 1.00 1.00 1.00 EXpOSOd 52 91'1 2.21 ( 0.88- 5.54)~ 2.32 ( 0.92- 5.85)~ 2.06 ( 0.82- 5.18) ~ 2.30 ( 0.91- 5.82) fxcludrd/Trandj 0 01 s UNITED IUNGDOM Non exposed Exposod Excluded/Trend 13I 1 IIIf3 ! 0~ b'2 1.00 1.00 78 0.76 ( 0.31• 1.83) 0.73 ( 0.30• 1.79) f 0~ 1.00 0.76 ( 0.31- 1.88) (1) MadeJ Mdudo acx, centcr, sex'oenterand age (2) Model include sex center, sex'center, age and proportion of residential type in the last 35 yrs (REUP) (3) Model include sex, center, sex'center, age, proporlion of residential type in the last 35 yrs (REUP) and edurational level (EDUC) (4) Model tnGude sex, center, sex center, age and tluration 0( exposure to list A agents (OCLAY) (5) Model fndud® sex, center, sex'center, age and frequency consumption of vegetables (VEGE) 1.00 0.64 ( 0.25- 1.61) i.00 0.73 (, 0.30- 1.79) Risk estim-atas,-Workoiace

S1AV Spouse, Average exposure (cigareites/tlay) ALL CENTERS ~ Total ,L Exposed Une~tOosed Exduded Min P10 01 ; Median ( c03 ( P90 Max Mean { Std MCn 1 Casts 138 22 116 0 0.13 1.57 3.00 4.51 7.00 8.37 10.31 d.82 2.76 Controlf S17 58 451 8 0.10 1.00 2.00 4.14 7.18 11.79 ~ 25.71 5.52 ~ 5.13 All 672 80 567 25 0.10 1.00 2.04 4.35 7.09 10.16 25.711 - - - 5.33 - 4.58 - WortfCn ChCs 466 244 181 61 0.05 1.57 2.86/ 0^.00 10.29 1 21.21 53.31 8.90 9.18 Conl701i 085 491 327 67 0.05 1:.50 3.19 5.64 51.25 18.11 60.00 8.21 7.56 A!I 1520 735 508 277 0.05 7.50 3.00 5.71 10.97~ 19.13 60.00 _ 8 _ 8.14 All C~SCf 650 266 297 87 0.05 1.57 2.86 5.86 10.00 20.42 53.31fp 8.56 8.90 Conttols 1542 549 778 215! 0.05 1.50 3.00 5.57 10.43 17.6 60.00! 7.92 7.39 A11 2192 815 1075 3021 0.05 1.50 3.00 5.S7 10.00 18.57 60.00f 8.13 7.91 ALL CENTERS WITH EDUCATIONAL LEVEL AND TYPE OF RESIDENCE MCn Cases 89 11 78 0 1.47 2.00 3.00 4.82 7.50 7.50 10.31 5.161 2.82 CGtlUolf 456 49 399 8 0.10 1.00 2.00 3.77 7.00 12.86 25.71 5.431 5.36 AIl 562 60 477 25 0.10 1.00 2.04 3.84 7.09 11.05 25.71 5.38 _ 4.98 Women Casts 383 192 136 55 0.10 1.57 2.74 5.20 10.00 20.83 53.31 8.60 9.38 COntro/s 742 425 254 63 0.09 ~ 1.56 3.34 5.71 11.43 18.57 60.00 8.42 7.67 All 1274 617 390 267 0.09 1.56 3.00 5.57 11.14 19.13 60.00 8.47 _ 8.23 A!I Casts 498 203 214 81 0.10 1.57 2.80 5.16 10.00 20.42 63.31 8.41 9.17 ConUd3 1338 474 653 211 0.09 1.50 3.00 5.57 91.25 t8.57 60.00 "0.11 F 7.51 All 1836 677 867 292 0.09 1.50 3.00 5.29 10.181 18.57 60.00 8.20 8.04 ALL C MM CSSCS 101 18 83 0 1.47 1 1.57 3.00 4.401 6.75 8.37 10.31 4.70 2.58 C9nttolS 292 31 256 5 0.10 1.00 2.25 5.001 7.89 11.43 20.00 5.81 4.46 All 410 49 339 22 0.10 1.00 3.00 4.577.50 10.31 20.00 5.40 3.88 WomCn C. 382 187 943 52 0.05 1.50 2.68 6.00 10.00 20.83 53.31 8.64 9.11 COntras 624 346 230 48 0.05 1.50 3.29 5.97 11.84 18.57 60.00 8.65 7.92 All 1155 533 373 249 0.05 1.50 3.00 6.00 11.43 19.14 60.00 8.64 8.35 Atl G95CS 509 , 205 226 78 0.05 1.50 2.80 5.29 10.00 20.00 53.31 8.29 8.80 Controls 1058~ , 377 486` 193 0.05 1.501 3.13 5.89~ 11.43 18.57 60.00 8.41 7.73 NI 1585 582 712 271 0.05 ^.50 3.00 5.71 11.25 18.57 60.00 8.37 8.11 FRANCS Men Cases Controls All 4 ^3 37 1 2 3 13 20 33 0 1 1 2.00 5.00 2.00 2.00 5.00 2 00 2.001 2.00 2.00 5.00 12.50 20.00 2.001 5.00 20.00 2.001 2.00 20.00 20.00 20.00 20.00 2,001 0.00 12.50 10.61 9.00 9.64 WomM CaSCs 63 93 26 4 0.20 1.29 2.68 6.75 10.00 22.86 50.00f 11.14 9.66 controls ~ 128 81 45 2 0.10 2.25 3.71 7.00 15.00 19.29 31.43 ~ 9.38 7.32 ~ All 191 114 71 6 0.10 2.00 3.34 6.93 13.08 I 20.001 50.00 9.46 8.55 AIl CiSCS 77 34 39 4 0.20 1.29 2.57 5.88 10.00 22.86 50.00 9.44 11.04 ~ Controls 951 83 65 3 0.10 2.25 3.71~ 7.00 15.00 20.00 31.43 9.46 7.35 All 228 117 104 7 0.10 2.00 3.34 6.86 93.08 20.00 50.00 9.45 8.54 GERMANYI MCn Cases 18 3 15 0 4.82 4.82 4.82 6.75 7.50 7.50! 7.50 6.36 i.3E Controls 129 12 113 4 0.10 2.25 3.05 6.48 8.77 11.79 13.39 6.25 4.0, All 147 15 128 4 0.10 2.25 3.11 6.75 7.89 11.79 13.39I 6.28 3."C WINrCn CSSCS 58 27 19 12 1.00I 1.30 3.00 6.32 13.93 20.42 53.31 9.90 11.7' Controls ~ 100 54 40 6 0.75 ( 2.25 3.75~ 5.57 11.25 17.68 37.50 8.85 8.0~ I All 158 81 59 18 I 0.75 2.14 ^.13 5.58 11.25 17.68 53.31 9.20 9.3E All CiSCs 76 30 34 12 1.00 1.72 3.00 6.38 13.50 18.571 53.31 9.54 11.1, Contro+s 2291` 66 153 10 0.10 2.25 3.29 5.73 10.711 17.14~ 37.50 I 8.38 7.5' All 3051 96 187 22 0.10 2.14 3.12 5.95 10.98. 17.14 53.31 8.74 8.7" GERMANY2 MCn Casts 29 4 25 0 1.47 1.471 2.23 5.25 8.91 10.31 10.31 5.571 4.0- COnUols ~ 65 5 60 0 2.25 2.25 3.75 4.50 5.00 ?.50 7.50 4.80 2.0: AII 94 9 85 0 1.47 1.47 3.00~ 4.50 7.50 10.31 10.31 5.14 2.9( WORiCn _ Cases 113 58 41 14 0.10 1.50 2.25 5.02 7.50 15.78 38.16 7.31 7.6f Controls 98 58 38 2 0.60 1.50 3.75 5.63 13.50 19.29 60.00 9.25 9.6" AII 211 1161 79 16 0.10 t.50~ 3.00 5.19 11.00 16.43~ 60.00 8.28 8.7f All Cases 142 62 66 14 0 .10 1.50 2.25 5.02 7.50 15.00 38.15 7.20 7.5! Controls 183 63 98 2 0.60 1 1.50 3.751 5.25 12.86 16.4360.00 8.89 9.3 AIl 305 125 164 16 0.10 1.50 3.00 5.16 10.00 15.78 00.00 8.05 8.5 MCn CgsCf 10 0 10 0 ~ Controls 14 1 13 1.00 0 1.00 :.00 1.00 1.001 ":.00 !.00~ 1.00 0.0' All 24 1 23 1 01 1.00 1.00 1.00 1.00 1.00 1.00 ~ 1.00 1.00 0.0 WOmCn Casts 21 8 12 1 1.50 1.50 2.131 3.75 6.38' 20.83 20.83 5.851 6.3 Controls 38 15 22 1 0.30 0.50 1.50 2.25 4.50~ 10.10 15.00~ 3.79 4.0 Al 59 23 34 2 0.30 0.75 1.50 2.25 6.00 10.10 20.83 4.511 4.9 AlI C2SCf 31 8 22 1 Jjjjj 1.50 1.50 2.13 3.75 6.38 20.83 20.83 5.851 6.3 Controls 52 16 35 1~ 0.30 0.50 1.25 1.90~ 4.16 10.10 15.00 3.621 3.9 N! 83 24 57 2 0.30 0.75 1.50 2.25, 5.63 10.10 20.83 4.36 4.E ITALY I Men Casas e 1 01 7.00 7.00! 7.00 7.001 7.00 7.00 7.00 7.00 0.0 Controls 103 12 88 3 0.81 1.00 1.23 2.04 7.15 7.86 25.71 5.34 6.9 All 111 13 95 3 0.81 1.00 1.29 2.09 7.00 7.86 25.71 5.46 6.6 WOrt1Cn I Casts 32 9 1 9 4 1.57 2.00 3.00 4.71 10.00 26.43 32.00 8.1 7.86 Controls i i 18 T 3 35 10 0.09 3.37 2.29 5.00 9.29 15.15 40.61 1 7.39 6.4 Al1 150 92 44 14 0.09 ~ ~ 2.29 3.37 5.00 9.29 15.15 40.61 7.48~ _ 6.E Al CeSCS 40 20 16 4 1.57 2.29 3.23 4.93 9.64 18. 57 32.00 ~ 7.82 7.5 Controls 1 1 85 1 23 13 0.09 2.00 3.00 5.00 8.94 61 15.15 40. ~ 7.101 6.c All 1 1 f6 105 39 1 17 0.09 2.00 3.00 5.00 9.00 1 1 5.15 40.61 i_.23i..__ - 6.7 WITH DIETARY DATA 2 ~63593397

D1WD Childhood 0-18 yrs, Weighted duration (years) ALLCENTERS Total Exposed Unexposed Exduded P.9in P10 Qt Median 03 P90 Max Mean Std Mon CBSC! 141 75 65 0.50 1.90 7.50 11.00 18.50 21.00 36.75 [ 12.76 7.84 Controls 531 . 321 201 9 0.15 1.90 8.50 15.00 1 19.00 28.00 65.50i 15.06 10.04~ All 672 396 266 101 0.15 1.90 8.50 14.25 19.001 25.00 65.50 14.62 9.70{ WOtMd1 CiSGS 509 314 187 8t 0.10 1.55 7.50( 13.50 19.00 22,00 57,00 13.41 8.70 Controls 1011 700 295 16i 0.10 2.50 9.50 15.50 19.00 25.56 57.50 ~ 15.09 9.04 ~ Al 1520 1014 482 24 0.10 1.90 9.00 14.25 19.00 23.00 57,50 14.57 8.97 AII teSCS 650 389 252 9 0.10 1.75 7.50 13.00 19.00 22.00 57.00 13.29 8.541 Conttoli 1542 1021 496 25 0.10 2.00 ~ 9.38 15.50 1 19.00 25.63 65.50 15.08 9.361 AH 2192 1410 748 34 0.10 1.90 8.50 14.25 19.00 23.00 65,50 14.58 9.181 ALL CENTERS WITH EDUCATIONAL LEVEI.. AND TYPE OF RESIDENCE Mtn CaSC3 92 49 42 1 0.50 2.50 8.501 11.00 18.50 22.00 36.75 13.05 7.85 Controls 1 14.50 19.00 26.00 65.50 14.97 9.84+ AH 562 339 213 10 0.15 2.20 14.25 8.50 19.00 25.00 65.50 14.69 9.59I Wot11ft1 CSISCf 408 258 140 8 0.10 1 .50 7.50I 12.00 19.00 21.50~ 57.00 13.19 8.47 Controls 888 816 239 13 0.10 2.95 10.50f 15.50 19.00 25.63 57,50 15.34 9.07I All 1274 874 379 21 0.10 2.25 9.50 14.25 19.00 23.00 57,50 14.71 8.94 All C71C1 EE 498 307 182 9 0.10 1.55 11.00 7.50 19.00 22.00 57.0011 13.17 8.36 ConUOlf 1338 906 410 22 0.10 2.50 1 9.5015.50 19.00 25.63 65.50~ 95.22 9.32I AII 1838 1213 592 31 0.10 2.25 9.38 14.25 19.00 23.00 65.50 14.70 9.12) ALL CENTERS W1TH DIETARY DATA Men C33Cs 104 58 45 1.05 1.80 6.50 11.00 18.50 22.00 36.75 12.43 8.231 Controls 306 185 118 3 0.15 2.50 8.50 11.00 19.00~ 22.00 38.00 13.62 8.501 AH 410 243 163 4 0.15 1.95 7.50 11.00 19.001 22.00 38.00 13.34 8.441 Women CsSCS 405 250 149 6 7.25 1.63 r 7.50 11.00 19.00 20.00 57.00 12.88 8.24 1 Controls 750 532 211 0.25 2.50 9.50 14.25 19.00 22.00 45.00 14.41 8.41 All 1155 782 360 13 0.25 1.90 8.50 14.25 19.00 21.00 57.00 13.92 8.381 AIl C5sC4 509 308 194 7 0.25 5.75 7.13 11.00 19.00 20.25 57.00 12.79 8.22! Controls 1 1056 717 329 10 0.15 2.50 9.38 14.25 1 19.00 22.00 45.00 14.20 1 8.44! AII 1565 1025 523 17 0.15 1.90 8.50 13.50 19.00 21.50 57.00 13.78 8.391 FRANCE Men Cases 14 4 10 0 1.05 1.05 7.78 16.00, 19.25 21.00 21.00 13.51 8.721 Conlrols 23 17 6 0 1.25 11.50 17.50 19.00 19.00 37.00 38.00 19.88 9.131 Atl 37 21 16 0 1.05 11.50 14.50 19.00 1 I 33.25 38.00 18.67 9.20 WoRYCn Cases 63 40 22 0.35 1.65 7.88 18,75 19.00 20.00 31.50 14.321 8.081 COnttols 128 97 31 0 1.15 2.50 9.50 18.50 19.00 20.90 45.00 14.84 8.18 ) All 191 137 53 1 0.35 1.90 9.50 18.50 19.00 20.00 45.00 14.68 8.13 AI COSCf 77 44 32 1 0.35 1.55 7.88 18.50 19.00 20.00 31.50 14.24 8.04 Controls 151 ',~14 37 0 1.15 2.50 10.50 18.50 19.00 1 21.00 45.00 15.59 8.48 All E 228 158 69 0.35 1.90 10.50 1 18.50 19.00~ 21.00 45.00 15.21 8.361 GERA9ANY 1 MCn Cases 18 11 7 0 1.50 3.00 5.50 11.00 18.50 19.00 22.00 11.32 6.751 Controls 129 75 53 1.10 4.00 9.00 11.00 19.00 21.00 33.50 13.06 6.89 AU 147 86 60 1.10 4.00 8.50 11.001 19.00 21.00 33.50 1 12.84 6.86 WofriOn ~ C8f0s 58 34 22 2 1.10 2.50 7.50 11.00 15.00 19.00 31.00 10.83 6.391 Contras AN 100 158 77 111 21 43 2 4 0.45 0.45 3.25 8.00 3.25 7.50 11.00 14.50 11.00 15.00 19.00 19.00 27.00 31,00 11.481 6.08' 11.28 6.16! Afl CaSCs Controlg AN 76 229 305 45 152 197 29 74 103 2 3 Si 1.101 0.45 0.45 2.50 7.50 4.00 8.38~ 3.25 6.00 11.00 15.50 i1.00 18.50 11.D0 17.50 19.00 19.00 9.00 31.00 33.50 33.50 10.95 6.401 12.26I 6.52; 11.96f 6.50 GERMANY2 MM C85Cf Controls All wornan Casas Controls All 29 i8 10 1 1.75 2.50 6.50 21.00 1. 1.00 26.50 28.50 11.29 7.49; 65 39 25 1. 0.15 1.35 5.50 10.50 11.00 17.50 33.00 9.52 6.09i 94 57 35~ 2 0,15 2.20 6.50 11.00 11.00 17.50 33.00 10.08 6.55' 1 13 61 52 0 0.45 1.10 6.50 11,00 11.00 21.00 28.50 10.63 6.58 98 59 38 1 0.25 1.10 5.50 11.00 11.00 16.15 22.00 9.26 5.14 211 120 90 1 0.25 1.10 5.50 11.00 11.00 17.43 28,50 9.96 5.93 ar C9S09 142 79 62 1 0.45 1.10 6.50 11.00 11.00 22.00 28.50 10.78 6.75 Conttolf 163 98 63 2 0.15 1.10 5.50 11.00 11.00 16.15 33.00 9.36 5.51 All 305 177 125 3 0.15 1.10 5.50 11.00 11.00 17.50 33.00 10.00 6.12 GERMANY 3 MCn C230f 10 3 7 0 10.50 10.50 10.50 11.00 11.00 11.00 51.00 10.83 0.29 Controls 14 7 8 1 0.85 0.85 1.05 4.50 11.00 11.00 11.00f 6.02 4.81 AA 24 10 13 1f 0.85 0.95 2.75 10.75 11.00 11.00 11.00I 7.47 4.57 WoriHIn CE34s 21 112 8 1 0.55 0.65 0.75 11.00 12.25 16.50 25.50 9.43 7.65 Controls 381 26 I 2 0 0.25 1.10 5.50 10.75 11.00~ 11.00 11.00 8.17 3.89 All 5~~~9 36 E 201 0.25 0.75 4.50 11.00 11.00 51.00 25.50 8.57 5.29 Atl C49CS 311 15 15 0.55 0.65 0.75 11.00 11.00 16.50 25,50 9.71 6.81 f Controls 52 33 18 5 ~ 0.25 1 1.05 4.50 10.50 11.00 11.001 1.00 7.71 4.12 I All 83 48 33 2 0.25 0.75 3.63 11.00 11.00 11.00 25.50 8.34 5.12 MM Cases 8 6 2 0! 5.15 5.15 9.50 16.50 19.60 26.50 26.50 15.63 7.63 Controls 103 70 28 5 0.30 1.23 7.75 18.25 19.05 33.45 54.25 16.11 ! 10.88 I AIl + -111 76 30 5 0.30 1.50 8.38 18.25 19.15 32.50 54.25 16.07 i 10.62 WOR1 Cn I Ci S CS 32 21 9 2 0.10 0.75 1.90 13.00 19.00 22.80 50.00 12.92 ?1.86 Controls 118 92 21 5 0.30 2.25 12.88 19.00 21.40 32.50 57,50 18.63 f 11.07 AII 150 113 30 7 0.10 1.50 9.95 19.00 20.90 28.50 57.50~ 17,57 11.39 All GisCf 40 27 11 2 0.10 0.75 4.50 13.13 19.00 23.SOt 50.00 13.52 10.99 Conlrois 221 162 49 10 0.30 1.90 10.50 19.00 20.65 32.50 57.50 17.54 1 1.02 AH 261 189 60 12 0.10 ?.50 9.50 19.00 20.50 32.50 57.50 16.97 11.08 2063593353

E - S3TP 5pouse and other cohabitants, exposure to different tobacco products Lwm) of mx suro Casms Controts 0 1 95% CI ; 0 2) 95% CI OR(3) 95% CI 0 4 95% CI ~ 0R(5 95X CI ( Non exposed 100 405 1.00 1.OO t.oo 1. 00 t.oo Only cigarette 39 5 11 1.50 ( 0.92- 2.44) 1.52 ( 0.89- 2.59) 1.63 ( 0.82- 3.25) 1.57 ( 0.96- 2.57) 1.82 ( 1.03- 3.21) Never cigarette 0 3 0.00 ( 0.00-99.99) 0.00 ( 0.00-99.99) 0.00 ( 0.00-99.99) 0.00 ( 0.00-99.99) 0.00 ( 0.00-99.99) Cigarette + other 0 2 0.00 ( 0.00-99.99) 0.00 ( 0.00-99.99) 0.00 ( 0.00-99.99) 0.00 ( 0.00-99.99) 0.00 ( 0.00-99.99) E,rcludtd/Trtrrd 2 ~ € WOMEN ONLY Non fxposmtl 160 312 1.00 1.00 ( 1.00 1.00 1.00 Only oiparatte 255 492 0.96 ( 0.74- 1.25) 0.95 ( 0.72- 1.26) 0.90 ( 0.65- 1.24) 0.98 ( 0.75- 1.27) 0.87 ( 0.64• 1.18) oiqar@tte Never 10 25 0.65 ( 0.30- 1.43) 0.45 ( 0.19- 1.09) 0.50 ( 0.20- 1.24) 0.73 ( 0.33- 1.62) ~ 0.67 ( 0.30- 1.471 Ciparattf + other 48 74 1.14 ( 0.74- 1.75) 1.16 ( 0.74- 1.81) 1.05 ( 0.63- 1.77) 1.14 ( 0.74- 1.76) 1.14 ( 0.72- 1.80) Ercludod/Trond 06 108 E ~ POPULATION BASED STUDIES Non axposao 163 510 1.00 1.00 1.00 1.00 1.00 only oSparett@ 168 367 1.13 ( 0.84- i.st) 1.13 ( 0.84• 1.53) 1.16 ( 0.82- 1.65) 1.14 ( 0.85- 1.54) 1.24 ( 0.89- 1.73) Nmvmr cigarette 7 18 0.67 ( 0.26- 1.71) 0.60 ( 0.22- 1.62) 0.73 ( 0.26- 2.01) 0.73 ( 0.28- 1.89) 0.78 ( 0.30- 2.04) ~ + othar Cigarette 35 50 1.24 (, 0.74- 2.06) 1.29 ( 0.77- 2.16) 1.16 ( 0.63- 2.14) 1.23 ( 0.74- 2.06) 1.39 ( 0.80- 2.39) Exc1 udad/Trand 5 5 ` HOSPITAL BASED STUDIES Non fXposmtl 89 153 1.00 1.00 1.00 1.00 1.00 Only cigarette 126 240 0.98 ( 0.67• 1.43) 0.85 ( 0.54- 1.34) 0.73 ( 0.41- i.30) 1.01 ( 0.69- 1.49) 0.71 ( 0.44- 1.13) Never ciqarette 31 10 0.70 ( 0.18• 2.68) 0.20 ( 0.02- 1.63) 0.21 ( 0.02. t.81) 0.79 ( 0.20- 3.09) 0.50 ( 0.13- 2.00) Cigsrotte + other 13 26 1.07 ( 0.50- 2.28) 0.94 ( 0.42- 2.10) 1.01 ( O.aO• 2.56) 1.11 ( 0.52- 2.37) 0.99 ( 0.45- 2.19) Excluded/Trsnd 1 15 23 ~ 11'fTHOUT OCCASIONAL SMOKERS Non mxposmtl 190 515 1.00 1.00 1.00 _ 1.00 ` 1.00 Only cigarette 231 451 1.19 ( 0.91- 1.56) 1.16 ( 0.86• 1.55) 0.99 ( 0.71- 1.38) 1.20 ( 0.91- 1.58) 1.06 ( 0.77- 1.46) Never cigarette l 8 23 0.71 ( 0.30• 1.68) 0.53 ( 0.20- 1.39) 0.52 ( 0.19- 1.37) 0.80 ( 0.33- 1.94) 0.72 ( 0.30• 1.75) Cigaratt@ + other 31 50 1.17 i, 0.69- 1.98) 1.12 ( 0.65- 1.93) 1.02 ( 0.56- 1.83) 1.16 ( 0.68- 1.97) 1.22 ( 0.70- 2.12) Excludtd/Trsnd ss 65 1 ~ AGE e56 YEARS Non @%poSftl 82 193 1.00 1.00 1.00 1.00 1.00 Only cigarette 69 143 1.00 ( 0.65• 1.53) 0.91 ( 0.56- 5.48) 0.99 ( 0.55- 1.76) 1.01 ( 0.65- 1.57) 1.07 ( 0.65- 1.78 ) Nov@r cigarette 4 5 1.45 ( 0.35- 5.91) 1 1.03 ( 0.22- 4.85) 1.22 ( 0.24- 6.34) i 1.50 ( 0.37- 6.15) ~ 1.46 ( 0.35- 6.04 ) Cigarette + other 7 16 0.83 ( 0.31- 2.23) 0.86 ( 0.31- 2.37) 0.71 ( 0.19- 2.59) 0.88 ( 0.33- 2.37) 0.79 ( 0.27. 2.29) Excludsd/Tnnd 9 4 !!! ~ tion a%pot@tl 83 250 1.00 1.00 1.00 1.00 1.00 95 2141 0.97 ( 0.63• 1.49) 0.87 ( 0.55- ?.38) 0.63 ( 0.37- 1.08) 0.99 { 0.64- 1.54) 0.92 ( 0.55- 1.561 4 10 0.94 ( 0.26- 3.42)I 0.64 ( 0.15- 2.64) 0.53 ( 0.13- 2.19) 0.93 ( 0.26- 3.40) 1.06 ( 0.28- 4.01) Ciparmtte + other 13 26 1.10 ( 0.50- 2.42) 1.03 ( 0.46• 2.29) 0.88 ( 0.35- 2.22) 1.01 ( ~ 0.45- 2.26) 1.39 ( 0.59- 3.25) Excludtd/Trtnd 15 52 ~ ) ( E AGE 6S+ YEARS Non fxposao 95 274 1.00 1.00 1.00 t.00 `: 1.00 Only cigarette 130 250 1.22 1 0.84- 1.76) 1.34 ( 0.91- 1.99) 1.50 ( 0.92• 2.44) 7.23 ( 0.85- 1.79) I 1.14 (, 0.75- 1.73) Never cigarette 2 13 0.24 ( 0.05- 1.13) 0.13 ( 0.02- 1.07) 0.18 ( 0.02- 1.48) 0.29 ( 0.06- 1.42) 0.26 ( 0.05- 1.25; Cigarette + other 28 34 1.42 ( 0.78- 2.60) 1.55 ( 0.83- 2.90) 1.48 ( 0.71- 3.09) 1.47 (, 0.80- 2.69) 1.37 ( 0.73- 2.58, Excludtd/Trend 20 58 ~ ` HISTOLOGICALLY CONFIRMED DIAGNOSIS Non exposed 252 717 1.00 1.00 1.00 1.00 1.00 : Only cigarette 283 607 1.04 ( 0.83- 1.32) 1.03 ( 0.80- 1.33) 1.03 ( 0.77- 1.39) 1.07 ( 0.84- 1.35) 1.04 ( 0.79- 5.36i Never cigarette 10 28 0.67 ( 0.31- 1.44) 0.47 (- 0.19- 1.12) 0.54 ( 0.22- 1.34) 0.75 ( 0.34- 1.63) 0.72 ( 0.33• 1.58) Cigarette + other 48 76 1.17 ( 0.77- 1.79) 1.19 ( 0.77- 1.83) 1.12 ( 0.68- 1.86) 1.18 ( 0.77- 1.81) 1.25 ( 0.80- 1.96: Excludtd/Trend SQUAMOUS CELL CARCINOM A 34 1 ,14 1 Non fxposf o a3 717 1.00 1.00 1.00 1.00 1.00 Only cigarette ! 50 607 1.03 ( 0.64- 1.68) 0.84 ( 0.49- 1.42) 0.71 ( 0.38- 1.31) 1.03 ( 0.63• 1.68) 1 0.70 ( 0.39- 1.25) N@Ve ~ r Cipar@tte 1 28 0.37 ( 0.05. 2.89) 0.31 ( 0.04- 2.47) 0.37 ( 0.05• 3.03) 0.39 ( 0.05- 3.06) 0.31 ( 0.04- 2.43 ) Cigarette + other 6 76 0.90 ~ ( 0.35- 2.29) 0.80 ( 0.31- 2.07) 0.73 ~ ( 0.25- 2.10) 0.89 ( 0.35- 2.27) ~ 0.82 ( 0.31- 2.14) t~eludtd/Trandj 9 714 SMALL CELL CARCINOMA von exposmo 30 717 1.00 1.00 1 00 0 1.00 1.00 Only cigarette 28 607 7.24 ( 0.67- 2.31) 1.21 ( 0.63• 2.30)~ 1.27 ( 0.63- 2 57) 1.29 ( 0.68- 2.42) 1.23 ( 0.64- 2.37 ) Never cigarette 1 28 0.54 ( 0.07- 4.39) 0.52 ( 0.06- 4.22) 0.62 ( 0.07• 5.20) 0.65 ( 0.08- 5.33) 0.55 ( 0.07• 4,51) Cigarette + other 6 76 1.03 ( 0.37- 2.83) ~ 0.84 ( 0.28• 2.51) 0.92 ( 0.30• 2.86)I 1.04 ( 0.38- 2.89) 1.02 ( 0.37- 2.85) Excludid/Trand 5 `Y4 t ADENOCARCINOMA Non exposetl Only cigarette Never cigarettf Cigarette + other Excl uded/Trend 133 717 1.00 1.00 1.00 1.00 7.00 156~ 607 1.02 (, 0.76- 1.36) 1.05 ( 0.77- 1.44) 1.02 ( 0.70- 1.48)~ 1.05 ( 0.78- 1.41) 1.10 ( 0.79- 1.54) 6 28 0.71 ( 0.28• 1.82) 0.49 ( 0.16- 1.49) 0.57 ( 0.18- 1.76)~ 0.80 ( 0.31- 2.08) 0.78 (, 0.30- 2.04J ~ 22 76 0.98 ( 0.57- 1.68) 1.02 ( 0.58- 1.80) 0.88 ( 0.45- 1.7a) 1.02 ( 0.59- 1.76) 1.06 ( 0.59- 1.91) i 16 1>4 ( OTHER Non @xpos@o 45 777 1.00 1.0o t.oo t.oo t.oo Only cigarette 49 607 1.07 ( 0.67- 1.72)~ 1.os r, 0.65- 1.79)) t.2a ( 0.68- 2.24) 1.1a ( 0.71- 1.84) 1.oa ( 0.60- 1.81) Never cigarette 2 28 0.95 ( 0.21- 4.33) 0.48 ( 0.06- 3.74) 0.67 ( 0.08- 4.89) 1.09 ( 0.24- 4.97 ) 1.06 ( 0.23- 4.92) Cigarette + Other 14 761 2.25 ( 1.09- 4.62)~ 2.42 ( 1.15- 5.07)~ 2.55 ( 1.06- 6.12) 2.21 ( 1.05- 4.63) 2.59 ( 1.21- 5.53)i Excludtd/Trand 4 ?14 e I >7ii% OF LIFESPAN IN RURAL AREA OR INTERMEDIATE CITIES Non mxposetl 110 269 1.00 1.00 - 1.00 1.00 1.00 Only cigarette 107 182 1.03 ( 0.69- 1.52) 1.03 ( 0.69- 1.52) 0.77 ( 0.47- 1.25) I 1.01 ( 0.68- 1.51) 0.87 ( 0.57. 1.34) Never cigarette 3 15 0.33 ( 0.09- 1.26) 0.33 ( 0.09- 1.26) 0.37 ( 0.09- 1.45) 0.35 ( 0.09- 1.31) 0.32 ( 0.08- 1.20) Cigarette + other ) 20 35 0.90 ( 0.47- 1.75) 0.90 ( 0.47- 1.75) 0.92 ( 0.44- 1.93)1 0.88 ( 0.45- 1.73) 0.88 ( 0.44• 1.73) 5xcludad/Trand~ 16 74 :,755C OF LIFESPAN IN URBAN AREA NOn eXpos@tl 86 313 1.0o t.ao 1.00 ~ t.oo 1.00 ciparftri Only 120 327 1.06 ( 0.74- 1.54) 1.06 ( 0.74- 1.54) 1.23 ( 0.80- 1.88) 1.04 ( 0.72• 1.51) 1.18 ( 0.77- 1.81) Never clplrmtte 2' 10 0.41 ( 0.08- 2.02) 0.41 ( 0.08- 2.02) 0.53 ( 0.10- 2.72) 0.52 ( 0.10- 2.72) 0.53 ( 0.10- 2.74) Cigarette + other 22i 32 1.51 i, 0.78- 2.92) 1.51 ( 0.78- 2.92) 1.48 ( 0.66- 3.30) 1.53 ( 0.79- 2.97) 1.78 ( 0.85- 3.71) Excludsd/Trond ~ l 14 29 (1) Mod.l fnc}ude sox, center, sex'centcr and age 2063593422 (2) Model Indudm sox, center, sex'cantoL ape and proportion of residentiat type in the last 35 yrs (REUP) (3) Modal tnolude 3ex, center, sex'canter, age, proporfron ot residential type in tha lest 35 yrs (REUP) and educational tevet (EDUC) (4) Modet Inciude sax, centar. sax'center, age and duration of exposure to list A agents (OCLAY)

WOTS tNorkpJace, Time since last ETS exposure (years) MEN ONLY Total Exposed Un Excluded Min { P10 : 01 Median t 03 ; P90 ~ Max __ I _ Mean Std Men C9.:C5 157 106 So 1 O.oo 0.00 0.00 S.oO 1a.oo 31.00 52.OO ~ 9 ao i2.8- COnlrols S80 388 192 0 0.00 0.00 0.00 6,00 16.00~ 31.00 54.00 10.51 ~ ?2.6 All 737 494 242 1 0.00 0.00 0.00 6.00 16.001 31.00 54.00 10.3 12.6 WOtnM C85CS 0 0 0 0 I F- - - Controls 0 0 _ 0 0 ~ AN 0 0 0 01 t €f! ~ All C35CY 157 706 50 10.00 0.001 0.00 5.00 14,00 31.00 52.00! 9.80 12.8: Controls 5 0 388 192 0 Q 6.00 1 31.00 54.00 ~ 10.5 12.6 3 7 4 94 242 0.00 9 0.00~ .00f .00 6.00 16 31.00 54.00 10.36 12.6 WOMEN ONLY Mcn c8sas Controls ~ Nt ~ 0 0 0 2063593407 9 a o 0 0 WOr1td'f C93C3 550 270 279 1 0.00 0.00 1.00 9.00 23.00 39.00 57.00 14.21 15.2' CGntrds 1076 476 599 1 0.00 0.00 2.00 13.50 ~ 32.50 44.00 57.00 18.23 16.6' All 1826 746 878 "c 0.00 0.00 2.00 112.00 30.00 42.001 57.00 -- 16.78 16.2' - All Cases Sso 270 279 1 0.00 0.001 1.00 9.00 s7.00 23.00 39.00 14.21 15:z: COntf0ls 1076 476 599 1 0.00 0.00 2.00 13.50 1 32.50 44.00 57.00 18.23 16.6' Atl 1828 746 878 2 0.00 0.00 2.00 2.00 30.00 42.00 57.00 16.78 16.2 POPIR.ATION BASED STUDIES MCn Cases 91 72 19 0 0.00 0.00 0.00 5.00 'p 15.00 31.00 52.00 10.401 13.1 Controls 444 328 116 0 0.00 0.00 0.00 ".00 ! 17.00~ 32,00 54.00 10.87 12.8' All 535 400 135 0 0.00 0.00 0.00 6.00 ! 16.50 31.50 54.00 f 10.79 12.9 Wanerl Cases 287 170 117 0 0.00 0.00 2,00 11.00 25.00 39.00 57.00 15.32 15.3. Controls 506 257 249 0 0.00 0.00 4.00 ~ 14.00 33.00 44.00 56.00 18.67 16.5. Atf 793 427 366 0 0.00 0.00 3.00 13.00 30.00 43.00 57.00 17.33 16.1 All 07ses 378 242 136 0 0.00 0.00 1.00 9.00 23.00 38.00 57.00 13.86 14.8 Controls 950 585 365 0 0.00 0.00 1.00 9.00 24.00j 39.00 56.00 14.29 15.0 AIl 1328 827 501 0 0.00 0.00 1.00 9.00 23.00~ 39.00 57.00 14.17 15.0 HOSttTAL BASED STUDfES MCn Cases 47 ContrOls 73 29 17 0.00 0.00 0.00 4.00 3.00 38.00 44.001 6.90 12.9 38 35 0 0.00 0.00 0.00 4,00 12.00 19.00 46.00 7.87 11.2 All 120 67 52 11 0.00 0.00 0.00 4.00 11.001 20.00 46.00 8.31 11.9 WOfDCn CSSCS 199 86 110 1 0.00 0.00 0.00 5.00 1:7.00 39.00 52.00/ 71.93 15.0- COrltrols 379 153 225 1 0.00 0.00 0.00 9.00 26.00 37.00 50.00 14.12 14.7 AN 578 241 335 2 0.00 0.00 0.00 8.00 24.00 38.00 52.00 13.32 14.8 A71 CasCs 246 117 127 2 0.00 0.00 0.00 5.00 17.00 39.00 52.00 11.18 14.5 Controls 4521 191, 260 1 0,00 0.001 0.00 8.00I 23.00 36.00' 50.00 12.87~ 14.3 All 898 308 387 3 0.00 0.00 0.00 f 6.001 19.50 38.00~ 52.00 12.23 14.4 VYITHDUT OCCASIONAL SMOKERS Men Casos .12~ '2 40 0 0.00 0.00 0.00 5.00 14.50 38.00 52.00 10.36 13.6 Controls 406 258 148 0 0.00 0.00 0.00 6.00 16.00 32.00 54.00 10.80 12.8 A11 518~ 330 188 0 0.00 0.00 0.00 6.00 1:6,00 32.00 54.00 10.71 13.0 WOmcn C35CS 430 197 232 1 0,00 0.00 2.00 12.00 27.00 42.00 57.00 16.09 16.1 Controls 810 314 495~ 0.00 0.00 3.00 14.00 35.00 45.00 57.00 19.18 17_C AN 1240 51t1 727~ 2 0.00 0.00 2.00 93.00 33.00 43.00 57.00 17.98 16.7 AH CSs0.4 542 269 272 1 0.00 0,00 0.00 9.00 25.00 40.00 57.00 14.55 15.7 COntr0ls 1216 572 643 `. 0.00 0.00 1.00 10.00 27.50 41,00 67.00 ~ 15.40 15.8 All 1758 841 915 E 0.00 0.00 1,00- 10.00 26.001 41.00 57.00 15.13 15.8 h1Cn CSses ; 57 40 16 1 0.00 0.00 0.00 0.00 4.00 13.50 28.00 3.40 6.1 COnUGS 172 121 51 0 0.00 0.00 0.00 0.00 7.00 21.00 37.00 5.32 8.c All 229 161 67 7 0.00 0.00 0.00 0.00 5.00 17.00 37.00 4.85 s.t WORCn CaSES 138 80 5 1 0.00 0.00 0,00 1.50 10.50 20.50 31.00 6.00I 8. Controls 254 734 120 0 0.00 0.00 0.00 5.001 19.00 25.00( 33.00 10.3 9.09 AN 392 214 177 1 0.00 0.00 0.00 2.00 16.00 24.00 33.00 I 7.93 9.7 All Cesls 195 120 73 2 0.00 0.00 0,00 1.00 8,00 19.00 31.00 5.13 7.€ Controls 426 255 171 0 0.00~ 0.00 0.00 2.00 14.00 24.001 37.00 7.30 9.7 All 621 375 244 2 0.00 0.00 0.00 1.00 7Z 00 23.00~ 37.00 6.611 9.1 AGE55&4YEARS MCn CisC4 52 32 20 0 0.00 0.001 0.00I 4.00 17.50 38.00 40.00 10.72 14.£ Controls ~ 216 150 66 0 0.00 0.00 O.OOI 4,00 17.00 32.50 48.00 10.45 13.4 All 268 182 86 0I 0.00 0.00 0.00f 4,00 17.00 33.00 48.00 10.50 13.' WOn1ai 03ses 176 85 91 0 0.00 0.00 0.00 7,00 28.00 39.00, 43.00 14.13 15.' Controls 3 ' 169 190 0i 0.00 0.00 1.00 12,00 33.00 39.00' 50.00 17.31 15.' Ail 3~ 5i 254 281 01 0.00 0.00 1.00I 10.00 32.00 39.00+ 50.00 16.25 15.; AII CisCs ^c28 117 211 0 0.00 0.00 0.00 6.00 26.00 39.00 43.00 13.20 14.E COntrds 675 319 256 0 0.00 0.00 0.00~ 8.00 29.00 37.00 50.00 14.09 15.11 AN 803 436 367 0 0.00 0.00 0.00 7.00 28.50 38.00 50.00 13.85 15.1 AGE 654 YEARS Mcn Cases 48 34 14 0 0.00 4.00 7.00 11.00 20.00 40.00 52.00 16.47 13.i ~ Controls 192 117 75 0 0.00 4.00 8.00 11.00 19.00 39.00 54.00 15.95 12 .% All 240 161 89 0 0.00 4.00 8.00 11.00 20.00 39.00 54.00 16.07 13.C WOmCn C.73CE 236 105 131 0 0.00 3.00 6.00 16.00 32.00 48.00 57.00 20.52 16. t i Conlroi3 Controls 463 173 289 0.00 5.00 10.00 26.00 44.00 49.00 57.00 26.21 17.: I All 699 2781 420 O.OOI 4.00 9.00 19.00~ 42.00 49.00 57.00 24.06 17.; AA Cases 284 139 145 0 0.00 3.00 7.00 14.00 31.00 46.001 57.001 19.53( 15.: Controls 855 ~ 1 290 364 1 0.00 4.00 ~ 9.00 16.00 ~ ~ 39.00 47.00 ~ 57.00 I 22.07 ~ 16. All 939 429 5091 11 O,00I 4.00 15.00 8.00 36.0 47.00 57.00 21.25 16. Descriotive statistics - Wor}cDlace

S1 TS Spouse, Time since last ETS exposure (years) MEN ONLY Tolal Exoosed UnexDosed Excluded Min P10 Q1 Median ( 03 P90 Max Mean Std Mon CisCS 157 23 134 0 0.00 0.00 0.00 1.00 19.00 29.00 41.00 8.17 12.6C Controls 580 68 510 2 0.00 0.00 0.00 0.00 10.50 21.00 37.00 6.24 9.12 All 737 91 644 2 0.00 0.00 0.00 0.00 11.00 25.00 41.00 6.73 10.07 Won1Cn cases 0 0 0 0 ~ ~ Controls 0 0 0 0 ~ Ak 0 0 0 0 € I ~ All C83CS 157 23 134 0 0.00 0.0 0 0.00 1.00 19.00 29.00 41.00 8.17 12.6C Conltas 580 69 510 2 0.00 0.0 1 0.00 0.00 10.50~ 21.00~ 37.00 6.24~ 9.12 All 737 91 644 2 0.00 0.0 0 0.00 1 0.00 91.00 25.00( 41.00 6.73 10.07 WOMEN ONLY Men casc3 0 0 0 0 2~ 635934~&j ~635934~& ° Contras 0 0 0 O E All 0 0 0 0 € _ WotnCn cases 550 316 215 19 0.00 0.00 0.00 9.00 19.00 30.00 52.00 11.801 12.02 Controls 1076 632 420 F 24 0.00 0.00 ~ 0.00 9.00 19.00 28.00 50.00 ~ 11.45 11.49 All 1826 948 635 43 0.00) 1 0.00 0.00 9.001 79.00 29.00 52.00 11.57 11.6; All cases 550 316 215 19 0.00 0.00 0.00 9.00 99.00 30.00 52.00 11.80 12.02 Controls 1078 632 420 24 0.00 0.00 0.001 9.00 t9.00 28.00 50.00 ~ 11.45 11.49 ~ All 1626 948 635 43 0.00 0.00 0.001 9.00 19.00~ 29.001 52.00 11.67 11.57 POPUI.ATION BASED STUDIES Men Cases Controls All 91 444 635 16 60 76 75 383 458 0 1 0.00 0.00 0.00( 0.00 0.00 0.00 0.00 0,00 0.00 3.001 f 0.50~ 1.00 22.00' 11.00~ 12.00 31.00 20.50 25.00 41.00 37.00 41.00 10.25 6.45 7.25 13.90 9.17 10.35 womcn Cases 287 172 111 4 0.00 0.00 7.00 10.00 20.00 29.00 44.00 12.22 11.52 Controls 506 309 194 3 0.00 0.00 2.00 10.00 1 20.00 30.00 50.00 12.50 11.67 AII 793 481 305 7 0.00 0.00 1.00 10.00 20.00 30.00 50.00 12.40 11.60 AA CiSCs 378 188 186 4 0.00 0.00 0.00 9.00 20.00 30.00 44.00 12.05 11.72 Controls 11 0 389 577 4 0.00 0.001 0.00 9.00 18.00 29.00 50.00 11.52 11.51 AN . 1 132 557 763 8 0.00 0.00 0.001 9.00 19.00 29.00 50.00 11.70 `:1.57 HOSPITAL BASED STUDIES Men Cases 47 Conlras ~ 73 6 41 0 0.00 0.00 0.00 0.00 0.00 21.00 21.00 "s.so( 8.57 5 68 0 0.00 1 0.00 1 0.00 2.00 9.00 26.00 26.00 7.40( 11.04 All 120 11 109 0 0.00 0.00( 0.00( 0.00 9.00 21.00 26.00 5.27 9.47 Women CaSCS 199 114 70 15 0.00 0.00 0.00 7.00 17.00 30.00 12.15 ( 11.18 52.00 ConlraS 379 227 133 19 0.00i 0.00( 0.00 6.00 18.00 25.00 1 46.00 9.71 10.9E All 578 341 2031 34 0.00I 0.00 0.00 6.00 17.00 26.00 52.00 10.20! 1 11.39 An C85CS 248 120 111 15 0.00 0.00 0.00 7.00 17.00 28.50 52.00 10.79 12.12 conlras ~ 452 232 201 19 0.00 0.00 0.00 5.50 17.50 25.00 46.00~ 9.66 10.94 352 312 34 0.00 0.00 0.00 6.00 17.00 26.00 52.00 10.05 11.35 WITHOUT OCCASIONAL SMOKERS Men Cases Conlfos All 112 406 518 17 48 65 95 0 357 1 452 1 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00. 3.001 19.00 0.001 9.501 0.00( 10.00 29.00 15.00 21.00 41.001 29.00i 41.00 9.061 4.81 5.92 12.9C 7.43 9.2E WomCn CsSeS 430 240 173 17 0.00 0.00 0.00 8.00 19.00 30.00 52.00 11.44 11.90 ContrGs 810 461 3261 23 0.00 0.00 0.00 9.00 19.00 29.00 50.00 11.58 11.6E All 1240 701 499( 40 0.00 0.00 0.00 9.00 19.00 30.00 52.00 11.53 11.74 All C05CS 542 257 268 17 0.00 0.00 0.00/ 7.00 19.00 30.00 52_00 51.28 11.95 Controls 12161 509 683 24 0.00 0.00 0.00f 8.00 18.00 28.00 50.00 10.94 11.4e All 1758 766 951 41 0.00 0.00 '€ 0.00, 8.00 18.00 29.00 52.00 11.05 11.6' AGE 055 YEARS 57 Men Cases C0111r0i3 172 A11 229 10 47 0 0.00 0.00 0.00 0.50 3.00 19.00 29.00 4.50 9.06 26 145 1 t+.00 0.00 0.00 0.00 5.00'! 15.00 25.00 3.58 6.41 36 192 1 0.00 0.00 0.00 0.00 4.001 15.00 29.00 3.83 7.11 Women CeSCS 138 67 69 2 0.00 0.00. 0.00 2.00 16.00 23.00 27.00 7.51 9.OC ~ ConUOls 254 128 119 7 0.00 0.00I 0.00 3.00 91.50 17.00 5.921 7.2E 27.00 All 392 195 188 9 0.00 0.00 0.00 3.00 13.00 19.00 27.00 6.47 7.9: All CeSCS 195 77 116 2( 0.00 0.00 0.00 2.00 14.00 23.00 29.00 7.12 9.oC CorlUas 426 154 264 8 0.00 0.00 0.00 1.50 10.00 17.00 27.00 5.53 7.1E All 621 231 380 10 0.00 0.00 0.00 2.00 11.00 19.00 29.00 6.06 7.8; 62 7 45 0 0.00 0.00 0.00 3.00 25.00 31.00 31.00 11.86 13.3G ConlraS 216 18 1 198 0 0.00 0.00 0.00 3.50 ':1.00 26.00 28.00 7.00 8.8E 268 25 243 0 0.00 0.00 0.00 3.00 17.00 26.001 31.00 8.36 10.2: 176 701 68 '' 0.00 0.00 0.00 7.00 15.00 29.001 41.00 10.36 11.52 ConUCts 359 Afl 1 535 216 319 ' 32 200 9j 0.00 16~ 0.00 0.00 0.00 0.00 0.00 ~ 8.00 18.00 8.00 18.00 26.00 27.00 42.00 42.00 10.57 10.50 10. 4s 10.81 All cases 228 CotlUas 575 All 803 108 236 344 13 330 443 ' 0,00 9 0.00 16 0.00 0.00 0.00 0.00 0.00 0.00 0.00 6.50 18.00 8.00 17.50 8.001 18.00 29.00 26.00 27.00 41.00 42.00 42.00 10.45 10.30 10.35 11.5E 10.4' 10.71 AGE 65+ Y€ARS MCn Cases 48 6 42 0 0.00 0.00 0.00 0.00 19.00 41.00( 41.00 10.00 16.9E Controls 192 24 0.00 167 0.00 0.00 1.00 14.00 27.00~ 37.00 8.54 91.2' AA 240 30 1 209 1( 0.00 ~ 0.00 0.00 0.00 15.00 28.00 41.00 8.83 12.2< Won1Cn C.3SCS 236 148 78 10 0.00 0.00 4.00 12.00 22.00 33.00 52.00 ?4.74 12.8- Controls 463 286 169 8 0.00 0.00 3.00 13.001 22.00 33.00 50.00 14.59 12.6E All 699 434 247 18 0.00 0.00 3.00 93.00 22.00 33.00 52.00 14.64 12.7'< All Cases 284 154 120 10 0.00 0.00 3.00 12.00 22.00 33.00 52.00 94.55 12.9E Controls 655 310 336 9 0.00 0.00 3.00 13.00 22.00 33.00 50.00 14.13 12.6E All 939 464 456 '9 0.00 0.00 3.00 1 2.00 22.00 33.00 52.00 14.27 12_7E

WOWD Workplace, Weighted duration (hours x level) MEN ONLY Total Exoosed Unexposed Excluded Min ~ P10 Q1 Median ~ Q3 P90 Max Mean Std Men SCS i57 89 50 18 286.00 884.00 3744.00 14404.00 28080.00I 59280.00 207792.00 21498.52 29151.5' Controls 580 307 1921 81 10.40 1123.20 3120.00 9152.00 18720.00! 35880.00 198016.00 15348.66 22227.8: Afl 737 396 242 99 10.40 1040.00 3156.40 9635.60 20800.00i 37440.00 207792.00 16730.83 24055.8' WOR1cn CSSf3 0 0 0 0 Controls 0 0 0 0 ; All 0 0 0 0 ~ ( All Gesf9 ts7 39 So 18 286.00 884.00 3744.00 14404.00 28080.00 59280.001 207792.00 21498.52 29151.5' Controls 580 307 192 81 10.40 1123.20 3120.00 9152.00 18720.00 35880.00 198016.00 15348.66 22227.8: AM 737 386 242 99 10.40 1040.00 3756.40 9635.60 20800.00 37440.00 207792.00 16730.83 24055.8' WOMEN ONLY MM CasCS 0 0 0 0 Controls 0 0 0 0 A9 ~ 0 0 0 0 ~ -- -- t--- WCrt1Cf1 C8Sf3 550 206 279 65 31.20 520.00 2080.00 6578.00 19370.00 39592.801 142355.201 15355.141 22470.7E COf17Dlt 1078 404 599 73 20.80 $20.00 1664.00 4992.00 14560.00 29484.00 179712.00j 11669.57 19059.37 ~ AII 1626 610 878 '38~ _ 20.80 520.00 1820.00 5272.80~ 15340.00 33176.00 20332.1E 179712.00 12914.21 All C8:0S 550 206 279 65 31.20 520.00 2080.00 6578.00 19370.00 39592.80 142355.20 15355.14 22470.7c Controls 1076 404 599 73 20.80 520.00 1664.00 4992.00 14560.00 29484.00 179712.00 11669.57 19059.3' All 1626 610 878 138 20.80 520.00 1820.00 5272.801 15340.00 33176.00 179712.00 12914.21 20332.1E POPULATION BASED STUDIES Men C85CS 91 59 19 13 ' 286.00 624.00 2178.80 7488.00 27144.00 35796.801 101920.00' 19695.2' 16415.56 Controls ~ 444 253 116 75I 10.40 1248.00 3307.20 9152.00 17680.00 33280.00 198016.00~ 1 14332.96 19559.0~ AII 535 312 135 88) 10.40 982.80 ~ 3005.60 8845.20 19136.00 34320.00 198016.00 14726.78~ 19570.14 W0t11CA CaSC4 287 115 117 55 31.20 390.00 1560.00 4472.00 15990.00 38454.00 131040.00 13491.59 21787.2° Controls 506 197 249 60 20.80 374.40 1248.00 3744.00 ~ 8840.00 20800.00 91728.00 8620.94 14137.8< dU 78_34 _ 312 0 1 1 Af I CBSCT 378 136 68 3 1.20 520.00 1664.00 60 6.40 20176.00 35796.80 131040.00 14483.05 21089.6- Conlroi4 950 450 365 13 5 10.40 702.00 2080.00 6032.00 ~ 14560.00 28714.40 198016.00 11832.36 17607.0- All 1328 624 501 20 31 10.40 624.001 2022.80 6032.00 15496.00 32448.00 198016.00 12571.501 18664.11 HOSPITAL BASED STUDIES MCn CaSff 47 COnirol8 73 A!I ~ 120 1 ® 25 32 57 17 301 52 5 6 11 1216.80 78.00 78.00 4368.00 1123.20 1924.00 7280.00 18345.60 4264.00 15932.80 5824.00 17305.60 42432.00 29390.40 34944.00 70720.00 207792.00 33613.22 47840.00 182000.00~ 26998.24 70720.00 207792.001 29899.54 44081.15 38199.75 40638.99 ~WOR~Cn Ce5C9 ~199 79 `.i0 10 124.80 748.80 4368.00 9100.00 25480.00 56056.00 142355.20 19202.35 24435.07 ; f 379 Controls 141 225 13 41,60 1300.00 1 ~ 2990.00 8736.00 20800.00 38064.001 179712.00 17717.62 25935.13 I All I All 578 CiSft 246 220 104 335 127 3 15 41.60 124.801 I 1066.00 1216.80 3619.201 8860.80 4633.20 11076.00 22276.80, 28496.00 48235.20 179712.00 18250.77 59280.00 207792.00 22666.50 25360.5E i50711.79 Controls 452) 173 260 ?9 41.60 1123.20 3276.00 10400.001 <^3400.00~ 39603.20! 182000.00 19434.26 28697.55 All 698 277 387 34 41.60 1123.20 3993.60 10483.20 25001.60 53664.00 207792.00 20647.81 29456.44 WITHOUT OCCASIONAL SMOKERS Men Cases ~ 112 57 40 15 312.00 884.00 3952.001 18200.00 29952.00 55120.00 101920.00 20976.93 21260.12 Controls ~ 406 199 148 59 10.401 1248.00 3432.00 9672.00 18720.00 35880.00 198016.00 15337.89 21008.47 All 518 256 188~ 74 10.40 1248.00 3432.00 10228.40 20618.00 37492 00 198016.00 16593.46 21153.87 WOrt1e(1 C9509 430 140 232 58 124.80 624.00 2821.00 6968.00 18837.00 38725.82 142355.20 14953.31 215 88.98 Controls 810 253 495 62 41.60 702.00 1996.80 4992.00 16130.40 29120.00 179712.00 12400.68 19700.8<^ Al) 1240 393 727 120 41.60 624.00 2184.00 5408.00 16640.00 31616.00 179712.00 13310.02 20402.82 Atl Cases 542 197 272 73 124.80 780.00 2912.00 8320.00 21840.00 42432.00 142355.20 16696.19 21614.32 Controls 1216 452 643 121 10.40 832.00 2340.00 6697.60 17368.00 33072.00 198016.00 13693.84 20316.5 7 Atl ',758 a49 9151 194 10.40 832.00 2496.00{ 7280.001 18720.001 35360.00 198016.00 14605.18 20748.3 5 AGE c55 YEARS Men Cases 57 32 16 286.00 1216.80 3572.40 14690.00 25636.00 34112.00 59280.00 16392.89 14933.96 Controls ~ 172 93 51 28 78.00 ~ 1,123.20 1 1 1 2704.00 8736.00 15600.00 30160.00 198016.00 15238.87 27474.00 All ` 28 125 67 37 78.00 1 1 1 1123.20 2808.00 9568.00 17420.00 33072.00 198016.00 15534.30 24820.15 Women C85f7 138 61 57 20 31.20 520.00 1664.00 5460.00~ 21257.60 42120.001 68640.00 14834.19 19318.56 COnU01Y 254 115 120 19 52.00 416.00 1248.00 3900.00~ 9984.00 19916.00 53248.00 7855.57 10547.50 All 392 176 177 39 31.20 509.60 1365.00 4420.001 13489.89 ~ 29484.00 68640.00 10274.30 14543.73 All C85@L 195 93 73 29 31.20 624.00 1976.00 5552.00 23660.00 41600.00 68640.00 15370.52 17863.34 Controls 426 208 171 47 52.00 520.00 1586.00 5564.00 13533.00 22401.60 198016.00 11156.76 20255.49 All 621 301 244 76 31.20 572.00 1638.00 5824.00 15600.00 32448.00~ 198016.00 12458.68 19615.2c MCn C9sft 52 29 20 3 312.00 769.60 2178.80 15080.00 29952.00 67392.001 101920.00 23524.83{ 27728.91 COfllr01S ~ 216 118 66 32 10.40 1248.00 3120.00 9053.20 19136.00 37440.00 81900.00 74233.43 15495.99 All 2681 1471 86 35 10.40 936.00 2984.80 10093.20 20176.00 38324.00 101920.00 16066.43 1 8805.66 Women Cases 78 67 91 18 124.80 416.00 2080.00 7800.00 18283.20 37648.00 142355.20 14617.80 21034.93 Controls 359 145 190 24 104.00 676.00 2080.00 5200.00 15340.00I 31616.00 179712.00 13414.53 21188.84 All 535 212 281 42{ 104.00 624.00~ 2080.00 5772.001 16601.00~ 35100.00 179712.00 13794.81 21097.85 All G115f9 228 96 21 124.80 624.00 2129.401 9061.00 20306.00 47283.33 142355.20 17308.46 23471.73 Conlrols 575 263 256 56f€ 10.40 873.60 2184.00' ~ 6240.00 18200.00 35880.00 179712.00 13781.95 18819.10 All 803 359 367 771 10.40 832.00 2178.80 7425.60 18720.00i 37440.00 179712.00 14724.97 20194.71 AGE B5+ YEARS MCO ~ CdSCt 48 28 14 6 364.00 2402.40 4040.40 8517.60 31200.00 61568.00 207792.00 25234.86 ~40823.38 Controls 192 96 75 21 104.00 982.80 3400.80 9672.00 22152.00 37960.00 182000.00 16825.83 23684.71 All 240 124 89 27 104.00 1045.20 3525.60 9635.60 24200.80 39520.00 207792.00 18724.64 28487.82 WOR1Cl1 C35f3 236 78 131 27 156.00 520.00 2210.00 6427.20 19462.18 39592.80 131040.00 16395.90 25931.72 Controls 463 144 289 30 20.80 520.00 1908.40 5434.00 15704.00 31200.00 159120.00 12958.411 21598.11 All 699 222 420 57 20.80 520.00 2080.00 5642.00 17160.00 32760.00 159120.00 ?4166.17 23212.88 AA Cases 284 106 145 33 156.00 624.00 2730.00 7176.00 22256.00 56056.00 207792.00 18730.72 30610.53 Controls 655 240, 364 51I 20.80 780.00 2324.40 6424.60 18928.00 34480.22 182000.00 14505.38 22487.53 All 939 3461 509 841 20.80 780.00 2402.40 6604.00 19462.18 37960.00 207792.00 15799.85 25284.34 fJescsintive_staSisfi cs-WOrkDLace

E-WOEV bNorkplace, ever exposed OR(1) 95Y. C1 I _ OR(2) 95% CI ; OR(3) 957. CI ~_ OR(4) 959. C! Fxcluded/Trend WOMEN ONLY Non expos®o €xposed Excluded/Trsndl POPULATION ®ASED STUDIES 1.00 ~- 1 1.00 ---- -~1.00 ----~----- 5.00 9 1.13 ( 0.68- 1.86)~ 0.99 ( 0.58- 1.68) 0.90 ( 0.48- 1.68) 1.14 ( 0.69- 1.90) R ~ Non exposed 136 365 1.00 1.00 1.00 1.00 1.00 Exposed 242 585 1.17 ( 0.87- 1.57) 1.21 ( 0.90- 1.64) 1.12 ( 0.81- 1.56) 1.14 ( 0.84- 1.53) 1.13 ( 0.81- 1.57) €xcluded/Trend 0 0 1 HOSPITAL BASED STUDIES Non exposed Expos®d 127 260 1.00 1.00 1.00 1.00 1.00 119 192 1.24 ( 0.89- 1.74) 1.08 ( 0.73- 1.59) 1.11 ( 0.70- 1.77) 1.27 ( 0.90- 1.79) 1.12 ( 0.75- 1.66) Excluded/Trend 0 0 f ~ € €€€) Non exposed 219 540 1.00 1.00 € 1.00 1.00 1.00 EXpO7ed 267 564 1.21 ( 0.94- 1.56) 1.18 ( 0.90- 1.54)1 1.18 ( 0.88- 1.59) 1.19 ( 0.93• 1.54) )1 ( 1.09 ( 0.82- 1.46) Excludid/Trend 01 D! ~ [[[~ AGE <55 YEARS Non exposed 46 110 1.00 t.oo 1.00 1.00 1.00 Exposed 119 251 1.25 ( 0.80. 1.98)~ 1.29 ( 0.77- 2.18) 1.63 ( 0.89- 3.00) 1.26 ( 0.79• 2.01) 1.43 ( 0.82- 2.50) Ezcludid/Trend 0 0 III ( AGE 55=54 YEARS Non exposed Sa Exposed 1116 235 1.00 1.00 1.00 1.00 1.00 E 317ss 1.03 ( 0.71• 1.49) 0.94 ( 0.64- 1.38) 0.78 ( 0.51- 7.79)i 0.99 ( 0.68- 1.44) ~ 0.81 ( 0.53- 1.24) 1 ~ ~xcluded/Trcndl 01 E DI ~ E . AGE 65+ YEARS Non exposetl 136 342 1.00 Exposed ) 139 287 1.25 ( 0.89- 1.74) i:kcluded/Trendi 01 01 HISTOLOGICALLY CONFIRMED DIAGNOSIS Non exposed 1 262 687 1.00 Exposed 365~ 855 1.16 ( 0.93- 1.44) 1.00 1.00 1.00 1.20 ( 0.85- 1.71)~ 1.19 ( 0.80- 1.78)` 1.22 ( 0.87- 1.72) 1.00 E 1.22 ( 0.85- 1.76)i 1.00 1.00 1.00 1.00 1.12 ( 0.89- 1.42) 1.07 ( 0.83- 1.38) 1.14 ( 0.91- 1.42)~ 7.08 ( 0.84- 1.38) Excluded/Trend1 ~ D 11 I 1 l i SQUAMOUS CELL CARCINOMA Non exposen d8 Exposed ',3~ 687 855 1.00 1.27 ( 0.82- 1.97) 1.00 1.16 ( 0.72- 1.85) 1.00 1.28 ( 0.75- 2.17) ~ 1.00 ' 1.23 ( I 0.79- ?.91)1' 1.00 - )( 0.87 ( 0.52- 1.4 lf3 ~ gI c"xcluded/Trendi Df SMALL CELL CARCINOMA 01 i 2063593457 Non exposed 8 687 1.00 1.00 1 00 1.00 1.00 I Exposed 9 '2~ 855 1.17 ( 0.67- 2.04) 1.15 ( 0.65- . 2.04) 1.03 ( 0.57- 1.88) 1.13 ( 0.64- 1.98) 1.09 ( 0.61- 1.92)I ) fxcluded/Trend 0 tJ! E ADENOCARCINOMA Non exposed 145 687 1.00 1.0o E 1.00 1.00 1.oa Exposed 188 855 { .06 ( 0.81- 1.40) 1.04 ( 0.77- 1.40) 1.01 ( 0.73- 1.42)~ 1.08 ( 0.82- 1.43)~ 1.08 ( 0.79- 1.47) F f Excluded/Trend j D~ 11 f f ~ i OTHER Non 0%posed 43 1.00 687 1.00 1.00 1.00 1.00 Exposed ?2 1.26 ( 0.80- 2.00) 855 1.37 { 0.88- 2.11) 1.05 ( 0.63- 5.75)i 1.31 ( 0.84- 2.03) 1.38 ( 0.83- 2.26) Excluded/Trend~ D 01 >7594 OF LIFESPAN IN RURAL AREA OR INTERMEDIATE CITIES Non exposed 125 266 1.00 1.00 0.67- 1.32) 0.94 ( 0.67- 1.32) Exposed 131 309 0.94 ( 1.00 1 1.00 1.00 1.03 ( 0.70- 1.50)~ 0.92 ( 0.66- 1.30) 0.94 ( 0.66- 5.34) c"xc1 udad/Trend 0 D - ~73'.OF UFESPAN IN URBAN AREA Non exposAa Exposad Excluded/Trendl 01 (1) Model Indude sex, cen(er, sex•cen(er and age ! (2) Modcl (ndude sex. Cenler, sex'c~tter, age and proportion of residential type in the last 35 yrs (REUP) f3) MoOv lnauae s@x, oenter, sex'(xnter, age, proponion of resldential type in the Iast 35 yrs (REUP) and educational level (EDUC) (4) Moda( include sex, cCnler, sex'center, age end duration of exposure to Iist A agents (OCLAY) 1.00 7.15 ( 0.76- 1.74) 1 !4\ /,/M!hLinN rln wev <

S3TS Spouse and other cohabitants, Time since last exposure (years) tTALY 2 Men C3sCS 3 0 3 0 ContrDls 97 21 74 2 0.00 0.00 0.00 0.00 4.00 18.00 21.00 4.52 7.54 AII 100 21 77 2 0.00 0.00 0.00 0.00 4.001 18.00 21.00 4.52 7.54 WattCn Ca5t3 16 8 7 1 0.00 0.00 0.00 10.50 14.00 29.00 29.00 9.75 10.00 Controls 76 53 21 't 2 0.00 0.00 0.00 5.00 15.00 25.00~ 45.00 ~ 9.38 11.28 ~ A8 92 61 28 t 3 0.00 0.00 0.00 6.00 15.00 25.00~ 45.00 9.43 ~ 11.05 Af Ca3E2 19 8 10 1 0.00 0.00 0.00/ 10.50t /4.00! 29.00 29.00 9.75 10.00 COntrds 173 74 95 4 7 0.00 0.00 0.00 4.00 1 11.00 22.00 45.00 8.00 10.54 -, I AN I 192 __ 82 _ 105 5 1 0.00 1 0.00 1 0.00 4.00 13.00 22.00 45.00 1 8.17~ - 10.44 iTALY 3 Mdl C35tt 1 1 0 0 0.00 0.00 0.001, 0.00 0.00 0.00 0.00 0.00 0.001 Conlrcls 12 3 9 0 0.00 0.00 0.00[ 0.00 2.00 2.00 ~ 2.00 ~ 0.67 1.15 AIt 13 4 9 0 0.00 0.00 0.00~ 0.001 1.00~ 2.00 2.00 0.50 1.00 WINnCn CisG+s 15 11 3 1 0.00 0.00 2.00 6.00 13.00 21.00 32.00 8.91~ 9.89 COfltrOlS 30 24 13 1 0.00 0.00 0.00 0.50 10.50 ~ 15.00 40.00 6.17 9.72 t dA 53 35 16 2 0.00 0.00 0.00 4.00 12.00 21.00 40.00 7.03 9.71 A11 CJfCf 10 12 3 1 0.00 0.00 1.00 5.50 11.50 21.00 32.00 8.17 9,78 Controls 50 27 22 1 0.00 0.00 0.00 0.00 9.00 15.00 40.00 5.56 9.32 All 66 39 25, 2 0.00 0.00 0.00 2.00 10.00 21.00 40.00 6.36 9,41 PORTUOALI Men CaSC9 16 6 10 0 0.00 0.00 0.00 0.50 3.00 8.00 8.001 2.00 3.16 COntr0ls 8 ' 7 0 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 A11 24 7 17~ 0 0.00 0.00 0.00 0.00 3.00~ 8.00 8.00 1.71 2.98 WOrt1Cn G9Ses 33 23 10 0 0.00 0.00 0.00 0.00 2.00 11.00 18.001 2.39 5.07 Controls 31 19 10~ 2 0.00 0.00 0.00 0.00 12.00 22.00 30.00 6.21 9.58 All 64 42 20 2 i 0.00 0.00 0.00 0.00 5.00 17.00 30.00 4.12 7.60 All C2sCf 49 29 0 20 - 0.00 0,00 0.00 0.001 2.00 11.00 18.00 2.31~ 4.69 Controls 39 20 17 2 0.00 0.00~ 0.00 0.001 12.00i 21.00 30.00 5.90 9.43 AM 00 49 37 2 0.00 0.00 0.00 0.00 3.00f 17.00 30.00 3.78 7.16 RORfiUGAL2 Men CisoS 10 0 10 0 . i . Controls 17 6 11 0 0.00 0.00 0.001 3.50I 6.00 22.00j ^c2.00~ 5.83 8.40 All 27 6 21 0 0.00 0.00 0.00 3.50 6.00 _22.00 22.00 5.83 8.40 Women C7sCs e^3 19 3 0.00 0.00 0.00 3.00 15.00 33.00 46.00 9.26 13.20 Controls 361 17 19 0 0.00 0.00 8.00 15.00 26.00 30.00 32.00 15.71! 11.02 A!1 59 36 22 0.00 0.00 0.00 12.00 21.00 30.00 46.00 12.31 12.48 Atl C95Cf 33 E 19 13 1 0.00 0.00 0.00 3.00 15.00 33.00 46.00 9.26 13.20 ~ Controls 53' 23 30 0 0,00 0.00 1.00 13.00 22.00 28.00 32.00 13.13 11.14 I A3 861 42. 28.00 46.00 11.38 12.12 43 11 0.00 0.00 0.00 7.001 20.00 SPAJN MCn Cases 6 2 3 1 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.001 0.00 Controls 13 2 11 0 0.00 0.00 0.00 10.00 20.00 20.00 20.00 10.00 14.14 All 19 4 14~ 1 0.00 0.00 0.00 0.00 10.00 20.00 20.00 5.00 10.00 WGRiCn C3fCS 65 36 16 13 0.00 0.00 0.00 4.00 15.50 30.00/ 52.00 10.36 13.44 Controls 140 102 24 20 0.00i 0.00! 0.00 3.00 11.00 22.00i 46.00 7.24 10.02 ~ Ail 211 138 40 J 33 0.00I 0.00 1 0.00 3.00 13.00 23.00~ 52.00 8.05 11.05 All CESeD ~ 71 38 _ 19 14 0.00 0.00 0.00 3.00 15.00 30.00 52.00 9.82 13.28 ~ COntt0I3 159 104 35 20 0.00 0.00 0.00 3.00 11.50 22.00 46.00 7.^<9! 10.03 All 230 142 54 341 0.00 0.00 0.00 3.00 13.00~ 23.00 52.00 7.971 11.00 GWEDEN MCn Cases 23 12 11 0 0,00 0.00 0.00 11.00 33.00 39.00 41.001 15.58 17.13 ConUas 36 '.1 25 0 0.00 0.00 1.00 8.00 25.00 28.00 37.00 12.00 ~ 12.63 Aq 59 23 36 0 0.00 0.00 0.00 8.00 28.00 37.00 41.00% 13.87 14.92 Women C94Cf 47 25 21 0.00 2.00! 8.00 18.00 25.00 40.00 44.00 18.08 13.23 Controls 76 49 27 0~ 0.00 0.00 2.00 10.00 19.00 30.00 39.00 12.49 11.49 AN 123 74 48 1~ 0.00 0.00 3.00 13.50 23.00 32.00 44.00 14.38 12.311 All I C.iSCf i 70 COftrOls 112 AA 102 37 60 97 32 52 84 1 0 1 0.00 0.00 0.00 0.00 3.00 0.00 1.50 0.00 2.00 18.00 9.00i 13.00! 27.00 21.00 23.00 40.00 44.00 17.27 30.00 I 39.00 12.40 35.00 ' 44.00 14.26 14.41 11.60 12.89 UNtTED KINGDOM Men C9sCS 3 1 2 0 3.00 3.00 3.00 3.00 3.00 3.00 3.00 3.00 0.00/ Controls 14 3 11 0I 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 All 17 4 13 0~ 0.00 0.00 0.00 0.00 1.50 3.00 3.00 I I 0.75 1.50_ WORHIt1 C9tC5 23 17 6 0 0.00 0.00 1.00 11.00 25.00 44.00 48.00 15.41 15.951 Controls 126i 83 43 0 0.00 0.00 3.00 11.00 21.00 30.00 40.00 12.72I 11.27 1 ASI 149, 100 49 0 0.00 0.00 2.00 °1.00 22.00 30.50 48.00 13.18, 12.13 AII CBSCS 21 10, 8 0 0.00 0.00 1 00 /1.00 25.00 44.00 48.00 ?4.72 15.74 Controls 1 140 861 541 0 0.00 0.00 2.001 10.00 20.00 30.00 40.00 12.28 11.31 All 166 104 62 0 0.00 0.00 1.001 10.50 21.50 30.00 48.00 12.70 12.14 2063593452

S1TS Spouse, Time since last ETS exposure (years) ALL CENTERS Total Exposed Unexposed Excluded Min P10 01 I Median ` 03 ( P90 Max Mean ( Std MGY1 CSSCS 141 23 118 0 0.00 0,00 0.00 1.00 19,00 29.00 ' 41.00 8.17 12.60 ConlrOlB 5311 68 462 1 0.00 ~ 0.00 0,00~ 0,00 10.50 21.00'i 37.00~ 6.24 9.12 All 672 91 580 1 0.00 0.00~ 0.00 0.00 /1.00( 25.001 41.00 6.73 10.07 Woi,cn CasC4 509 303 187 19 0.00 0.00 1,00 9.00 19.00 30.00 52.00 12.00 12.05 Controls 1011 613 376 22 0.00 0.00 0.00 9.00 20.00 29.00 50.00 11.66 11.55 AII 1520 916 563 41 0.00 0.00 0.00 9.00 19.00 30.00 52.00 11.77 11.72 AI CiSC3 650 326 305 19 0.00 0.00 0.00 9.00 19.00! 30.00 52.001, 11.73 12.11 ContfO(3 1542 681 838 23 0.00 0.00 0.00 8.00 18.001 28.00 50.00 11.12 11.45 A11 .'.192 10071 1143 42 0.00 0.00 0.00 8.001 19.00 29.00 52.00~ 11.32 11.66 ALL CENTERS WfTH EDUCATIONAL LEVEL AND TYPE OF RESIDENCE Msn Cases 92 12 80 0 0.00 0,00 0,00 2.00 6.00 25.00 31,00 6.25 10.56 Controls 470 59 410 1 0.00~ 0.00 0.00 0.00 10.00 15.00 29.00 4.93 7.66 All 562 71~ 490 0.00( 0.00 0.00/ 0.00, 9.00 15.00 31.00 5,16 8.75 Womrn CSSeB 406 246 142 18 0,00 0.00 1.00 10.00 19.00 30.00 52.00 12.07 11,94 Controls 868 543 303 22 0,00 0.00 0.00 9.00 19.00 28.00 50.00 11.43 11.46 A11 1274 789 445 40 0,00 0.00 0.00~ 9.00 19.00 29.00 52.00 11,63~ 11.60 IN , CaseE 493 258 222 18 0.00 0.00 1.00 9.00 19,00 30,00 52,00 ':1,79 11.92 Controls 1336 602 713 23 0.00 0.00 0.00 8.00 17.00 ~ 27.00 50.00 10.79 11.30 All 1836 860 935 41 0.00 0.00 0.00 8.00 ~ 18.00 28.00 52.00 11.09 11.49 ALL CENTERS WITH DIETARY DATA Men CiSes 104 19 85 0 0.00 0.00 0.00 1.00 19,00 31.00 41,00 8.63 13.25 Contr0i4 306 39 267 0 0.00 0.00 0.00 3.00 1 11.00 26.00 37.00 7.41 9.92 All 410 58 352 0 0.00 0.00 0.00 2.50 11.00 28.00( 41.00 7.81 11.02 WOn16n CiSC3 405 240 149 16 0.00 0.00 1.00 10.00 20,00 31.50 52.00 12.68 12.29 Conlrol3 750' 452 279 19 0.00 0.00 0.00 9.00 19.00 28.00 50.00( 11.55 11.34 AII E 11551 692 428 351 0.00 0.00 1.00 10.00~ 19.50 29.00 52.00 11.94 11.6E All CiSCs 509 259 234 16 0.00 0.00 1,00 10,00 20.00 31.00 52,00 12.38 12.3E Controls 1055 491 546 19 0.00 0.00 0.00 9.00 19.00 27.00 50.00 11.22 11.28 All 1565 750 780 35 0.00 0.00 0.00 9.00 19.00 29.00 52.00 11.62 11,6E FRANCE Men 4 Cases 1 ! 13 0 0.00 0.00 0.00! 0.00 0.00 0.00 0.00 0.00 0.0~. ` Controls 3 3 20 0 0.001 0.00 0.00 i 9.00 26.00 26.00 26.00 I 11.67 13.2C AII 37 4 1. 33 0 0.00~ 0.00 I 0.00 4.50 17.50 26.00 26.00 8.75 12.2c Wonien Cases 63 37 26 0 0,00 0.00( 5.00 13.00 20.00 33.00 47.00 14.14 12.1: Controls 128 83 45 0 0.00 0.00 0.00 10.00 20.00 23.00 42.00 11.46 10.5_ All 191 120 71 0 0.00 0.00 1.00 11.00 20.00 26.00 47.00 12.28 11.c' All C85es :7 38 39 0 0.00 0.00 5.00 12.50 20.00 33.00 47.001 13:76 1' 'a Controls 151! 1 86 65 0 0,00 0.00 0.00 9.50 20.00 25.00 42.00 11.47 10.5% All 228 124 104 0~ 0,00 0,00 1.00 10.50 20.00 26.001 47.00 12.17 11 : GERMANYI Men Cases 18 3 15 01 0.00 0,00 0.00 3.00 31.00 31.00 31.00 11,33 1'.1;. Cantrols 129 16 113 0 0,00 0.00 0.00 3.50 9.50 13.00 29.00( 5.69 7. -: All 147 19 128 OI 0,00 0.0 0 0.00 3.00 ?0.00 29.00 31.00( 6.58 9:: Women CSSE4 ~ 58 3 7 19 2 0,00 0.00 4.00 12.00 19.00 26.00 36.00 12.76 6' Controls 100 60 40 0 0,00 0.00 3.50 14.00 21.50 26.50 50.00 13.93 11,2: AI) 156 97 59 2 0.00( 0.00 4.00 14.00 20.00 26.00 50.00 13.48 1C ° AIl GBSef 76 40 34 2 0,00 0.00 3.00 51.00 19.50 26.50 36.00 12.65 10.tt Controls 229 76 153 0 0,00 0.00( 1,501 12.50 17.00 26.00 50.00 12.20 1 '.G' A11 305 116 187 2 0,00 0.00 2,00( 12,00 19.00 26.00 50,00 12,35 10 7" MM C950s Controls AlI ~9 65 94 4 5 9 25 0! 0.00 0.00 60i 0I 0,001 0.00 85i Oj 0,00 0,00 0.50 0.00 0.00 5.00 0,00 1,00 17,00 3,00 9,00 25.00 15.00 25.00 25.00 15.00 25.00 8,75 3,60 5.89 11.5E 6.Sc 8.8' WOniCn C~SCS 113 72 41 0 0,00 0,00 0.00 5,50 17,50 27.00 41,00 10,65 11,95 Controls 98 60 38 0 0.00 0.00 0.00 13,00 20.50 29.50 37.001 12.70 11.2E All 211 132 791 0 0,00 0.00 0.00 10.00 20.00 28.00 41.00 11.58 11.6= AN Cases 142 76 66 0 0,001, 0,00 0.00 6.50 17,50 27.00 41,00 10.55 11,6- ' Cotltrois 163( 65 98 0 0.00( 0,00 0.00 10.00 20,00I 28.00 37,00 12,00 11.2' AII 305( 141 164 0 0,00 0.00 0.00 9.00 [ 19.001 27,00 41,00 11,22 11.5- CERMANY 3 Men CasCZ 10 Controls 14 All 24 0 `~ 10 13 23 0 01€ 01 10.00 10,00 10,00 10.00 10.00 10,00 1 10.00 10.00 10.00 10,00 10,00( 10.00 10.00 10.00 10,00 10,00 0.0C 0,0! WOUnOn C~SeS i 21 9 I 12 0 0,00 0,00 0.00 5,00( 18.00 34.00 34.00 10.44 14,0: Controls 38 16 22 0 0,00 0.00( 0.00 5,00 12.00~ 27.00 41.00 8,94 11.8• All 59 25 34 0 I 0,00 0.00 0,00 5.00 14,00' 32.00 41,00( 9.48 1<^.3E All C95C3 ' 31 9 22 0 0,00 0,00 0.00 5,00 18.00 34.00 34.00 10,44 14.0: Control9 52 17 35 0 0.00 0,00 0.00 5.00 10.00 27.00 41,00 9.00 11.4• AH 83 26 57 0 0.00 0.00 0.00 5,00 14,00 32.00 41.00( 9,50 12.1. Men Cases 8 i 7 0 3,00 3.00 3.00 3,00 3,00 3.00 3.00 3.00 0.0c Controls 103 14 88 1 0,00( 0.00 0.001 0.00 13.00 16.00 27.00 6,07( 8.9' All I 111 15 95 0.00 0.00 0.00 0.00 13,00 16.00 27.00 5,87 8,6: WomCn Cases 32 5 9 ? 0,00 0.00 2.00 8,50 21,00 30.00 32.00 11.82 10.7! Controls 118 83 35 0 0.00 0.00 0.00 8.00 20.00 32.00 43.00 12.01 12,5: 150 All 105 44 1 0.00 0.00 1.00 8.00 21.00 30.00 43.00 11.97 ',2,1c All ~- Cases € 40 23 16 1 0,00 0.00 2.00 7.00 21.00 30.00 32.00 11,43 10.6 2 Contfols ~ 21 97 123 11 0,000,00 0,00 8,00 17.00 30,00 43,00 11,15 12.2 _ A1f 261 120 139 2 0,00 0.00 0.00 7,50 18,00 30,00 43.00 11,21 11,8: 2063593414

S3CU Spouse and other cohabitants, Cumulatfve exposure (packs/day x years) tTAl.Y 2 70ta1 ~ Ecposed Unexposed Exduded Min P10 E 01 ~ Median E Q3 ~ P90 ~ Max E Mean j 6td 1 Men Ci5C3 3 01 3 0 ~ ControlE 97 21 i 74 2 0.54 0.90 1.80 2.93 7.37 ~ 12.86 16.71F ~ ` 5.23 5.12 ~ AN 100 f 21 77 2 0.54 0.90 1.80 2.93 7.37 12.86 16.71' 5,23 5.12 Womat C75b 16 7 7 2 `s.58 1.58 3.11 7.00 39.39 68.00 68.00 19.11 25.18 Co+ttrG3 78 46 21 9 0.08 1.19 3.20 7.18 12.80 ~ 30.00 52.82 11.15 12.50 Afl 92 53 28 11 0.08 1.50 3.20 7.00 12.80 34.71 68.00 12.20 14.69 Afl CasC3 19 7 10 2 1.58 1.58 3.11 7.00 39.39 68.00 68.00 19.11 25.18 ~ ~~ ~ ? 0 ~ A11 992 4 105 13 0.08 9 1. 2.57 5.22 12.58 25.07 68.00 10.23 13.07 fTALY 3 Men C33CS 1 0 0 1.89 1.89 1.89 1.89 1.89 9.89 1.89 1.89 0.00 Controls 12 2 9 1 0.13 0.13 0.13 0.77 1.40 1.40 1 1.40 0.77 0.90 AN 1 31 3 9 1 0.13 0.13 0.13 1.40 1.89 1.89~ 1.89 1.14 0.91 WOmCn C3:Qt 3 1 9 3 3 4.11 4.11 6.00 9.43 14.00 62.00 62.00 15.32 18.02 Controis 38 10 13/ 15 0.08 1 2.82 6.75 14.11 18.75 23.79 27.00 13.34 7.91 Atl 53 19 16i 18 0.08 4.11~ 6.00 13.711 15.84 27.00 62.00 14.27 13.29 AA CiSC'S 16 /0 3 3 1.89 3.00 4.35 8.96 14.00 38.86 62.00 13.97 17.51 Conttols 50 12 22 16 0.08 0.13 3.49 12.14 17.30 20.57 27.00 11.24 8.67~ A(I 60' 22 25 19 0.08 1.40 4.35 90.00 15.71 20.57 62.00 12.48 13.14 PORTUGALI M€n ~Sf3 16 6 10 0 0.28 0.28 1.00 1.41 7.50 8.86 8.86 3.41 3 J5 ConUWs 8 1 7 0 2.05 2.05 2.05 2.05 2.05 2.05 2.05 2.05 0.00 AN 24 7 17 0 0.28 0.28 1.00 1.67 7.50 8.86 8.86 3.22 3.46 1NOrnCt1 CSSCS 33 21 10 2 0.09 1.03 3.61( 14.46 24.64 ! 39.71 58.50 17.10 15.66I€ i Controls 31 17 10 4 0.11 0.14 10 3.47 2 8.14 16.57~ 16.84 5.51 5.27~ AN 64 38 20 6 0.09 0.15 ~ . 2.10 7.73 17.74 27.68( 58.50 11.92 13.37 All COSM 49 27 20 2 0.09 0.56 1.19 8.86 24.01 39.71 58.50( 14.06 75.00 Controls 39 98 17 4 0.11 0.14 2.05 3.33 8.14 16.57 16.84 5.32 5.98 A8 08 d5 37 6 0.09 0.28 1.67 6.75 16.57 25.07I 58.50 10.56 92.73 PORTUGAL2 Mcn Casbs 10 0 10 0 i t Controls 17 4 11 2 0.26 0.26 0.44 0.75 5.59( 10.29 10.29 3.01 4.86 All 27 4 21 2 0.26 0.26 0.44 0.75 5.59 10.29 10.29 3.01 4.86 WOmM CtseE 23 14 3 6 0.15 0.64 4.75 9.92 15.32 "00.21 76.03 16.73 22.71 Controls 36 14 19 3 0.44 0.93 1.67 2.93 7.35 12.30 33.50 6.00 ) 8.59 All 59 28 22 9( 0.15 0.64 1.67 5.34 13.10 33.50 76.03 11.37 , ':7.7fl AA CiSCE 33 14 13 6 0.75 0.64 4.75 9.92 15.32 60.21 76.03 16.73 22.71' controls 53 98 ~ 30 5 0.26 ~ 0.44 0.93 2.33 7.35 12.30 33.50 5.34 7.89 All 86 32 43 11 0.15 0.611 0.96 4.84 12.50 17.64 76.03 10.32 16.83 SP6JN MOtt CBsM 6 2 3 1 0.69 0.69 0.69 2.67 4.65 4.65 4.65 2.67 2.80 Controls 13 2 11 0 0.41 0.41 0.41 2.13 3.86 3.86 ~ 3.86 2.13 2.44 All 19 4 14 1 0.41 0.41 0.55 2.27 4.25 4.65 4.651 2.40 2.17 WOfnfX1 C2s83 85 30 16 19 0.10 0.91 2.50 7.57 23.97 35.23 55.80 13.77 14.88 CtklUols 146 83 24 39 0.13 0.91 4.50 9.75 21.23 30.54 56.14 13.81 13.09 All 211 113 40 58 0.10 0.91 3.21 8.79 21.23 31.57 56.14 13.80 13.52 AU CisC3 >1 32 9 7 20 0.10 0,90 2.18 6.01 22.11 34.11 55.80 13.07 14.66 Controls 159 85 35 39 0.13, 0.86 3.86 8.79 20.66 30.54 56.14 13.54 13.06 Aq .'30 117~ 54 59 0.10~ 0.86 2_.84 8.40 2066 .( 31.57 56.14 13.41 ~3.45 SWEDEld Men CSsC3 23 12 11 0 0.01 0.02 0.10 0.32 4.97 9.79 23.91 3.92 7.03 Controls 36 10 25 1 0.32 0.34 0.39 ~ 1.35 2.50 6.49 9.50 2.25 2.75 All 59 22 36 1 0.01 0.07 0.31 ' 1.13 3.20 9.50~ 23.91 3.17 5.47 WontCn Cases 47 23 21 3 0.01( 0.35 0.96 3.57 14.79 27.36( 37.53 9.57~ 11.62 Controls 76 48 27 1 0.02 0.05 0.37 5.17 7.94 12.51 26.60 5.61 5.86 ? A!I 123 71 48 4 0.01 0.06 ~ 0.55 5.03 9.34~ 16.50 37.53 6.89~ 8.31 All Cases _ 70 35 32 3 0.01 0.03 0.32 2.45 12.18 23.91 37.53 7.63 10.53 ~ Controls 912 58 52 2 0.02 0.06 0.39 :.47i 7.82 11.53 26.60 5.03 5.58 Afl 982 93 84 5 0.01 0.06 0.36 3.00' 7.881 14.79 37.531 6.01 7.87 UNITED (ONGDOM Mcn Casa3 3 0 0 3 Controls 14 0 0 14 ~ AN 17 0 0 17 i WorMn C3sCS ~ 23 0 0 23 ( ( Controls ii 128 0 0 126 i f[ g.~ ~ I AN 1 149 0 0 749 I i 0 A.11 C3Sr•E 26 0 0 26 I Controls 140 0 0 140 f AH 166 0 0 166 C.~3 ~ ~ 4N

C_S3CU Spouse and othercohabitants, Cumulative exposure (packsidayx years) MEN ONLY LwN of n Cuea Controlz 1 95% CI OR(2) 96% C! ~ O 3 85% CI OR(4) 95% CI ) OR(S) 95% CI ~ Non expo50tl 98 394 1.00 1.00 1.00 1.00 t 1.00 0<$3CU<r13 31 82 1.51 ( 0.87- 2.62) 1.51 ( 0.83- 2.75) 1.60 ( 0.70• 3.66) 1.62 ( 0.93- 2.82) 1.88 ( 0.98- 3.61) 13<S3CU<26 1 10 1.13 ( 0.13•f0.19) 1.44 ( 0.15•14.10) 0.00 ( 0.00-99.99) 1.18 ( 0.13•10.65) 2.84 ( 0.21•37.55) Excluded/Trend 11 451 0.32 0.36 1 0.35 0.30 ~ 0.32 WOMEN ONLY Non 0Xp09ea ~ 154 269 1.00 1.00 1.00 1.00 1.00 0<S3CU<r13 164 350 0.85 ( 0.64- 1.12) 0.85 ( 0.63- 1.14) 0.85 ( 0.60- 1.21) 0.85 ( 0.64- 1.13) 0.81 ( 0.58- 1.11) <S3CU<2$ 13 40 76 0.94 ( 0.60- 1.48) 0.83 ( 0.51- 1.37) 0.58 ( 0.32- 1.04) 0.99 ( 0.63- 1.56) 0.79 ( 0.46- 1.34) ~ 25<S3CU 38 58 1.28 ( 0.79- 2.06) 1.19 ( 0.72- 1.97) 1.04 ( 0.59- 1.84)~ 1.30 ( ~ 0.80- 2.10) 1.03 ( 0.59- 1.83) I ~rcludad/Trond 113 258 0.25 0.24 0.26 1 0.25 0.26 POPULATION BASED STUDIES Non expoaed 163 610 1.00 1.00 1.00 ( 1.00 ) 1.00 0<S3CU<13 118 278 0.97 ( , 0.71- 1.34) 0.98 ( 0.70- 1.35) 0.99 ( 0.67• 1.46) 0.99 ( 0.72- 1.37) 1.05 ( 0.73- 1.50)~ 13<S3CU<.25 16 46 0.80 ( 0.42- 1.52) 0.77 ( 0.40- 1.51) 0.58 ( 0•26• 1.28) 0.81 ( 0.42- 1.55) 1.15 ( 0.55- 2.41) 25<S3CU 19 29 1.39 ( 0.71- 2.69) 1.42 f 0.73- 2.77) 1.19 ( 0.57- 2.51) 1.42 ( 0.73- 2.77) 1.57 ( ~ 0.68- 3.62) Exc2udad/fiend 62 87 0.54 f 0.58 0.57 0.53 0.54 ) HOSPITAL BASED STUDIES Non •xposed 89 153 1.00 1.00 1.00 1.00 1.00 0<S3CU<13 7 154 0.95 ( 0.63- 1.43) 0.85 ( 0.52- 1.39)1 0.84 ( 0.45- i.57) 0.96 ( 0.63- 1.47) 0.7 8 ( 0.47- 1.28) 13<S3CU<2S 25 40 1.28 ( 0.69- 2.35)1 1.03 ( 0.51• 2.09) 0.67 ( 0.28- 1.60) 1.38 ( 0.75- 2 57) 0.66 ( 0.31- 9.38) 25<$3CU 19 29 1.39 ( 0.70• 2.77) 1.05 ( 0.48- 2.28) 1.01 ( 0.41- 2.53) 1.44 ( 0.72- 2.86) 0.84 ( 0.37- 1.87) Excludrd/Trend 96 76 0.21 ~ 0.22 0.19 ~ 0.20 0.21 W)THOUT OCCASIONAL SM01<ERS Non expozed 166 0<S3CU<13 144 13<S3CU<.26 ~ 30 25<S3CU 28 485 1.00 1.00 . 1.00 1.00 1.00 301 1.06 ( 0.78- 1.43) 1.02 ( 0.74- 1.41) 0.86 ( 0.59- 1.24) 1.06 ( 0.78- 1.44) 1.00 ( 0.71- 1.42) 71 0.92 ( 0.56- 1.53) 0.76 ( 0.43- 1 .34) 0.58 ( 0.30- 1.09) 0.97 ( 0.58- 1.61) 0.72 ( 0.39- 1.31} 47 1.24 ( 0.72- 2.15) 1.10 ( 0.61- 1.97) 1.02 ( 0.54- 1.95) 1.28 ( 0.74- 2.21) 0.85 ( 0.44- 1.64) Excludsd/Trend 98 200 0.58 0•59 0.64 0.58 0.60 AGE <56 YEARS Non expozea 82 191 1.00 1.00 1.00 ! 1.00 - 1.00 0<S3CU<:13 60 112 1.07 ( 0.68- 1•70)~ 0.93 ( 0.56- 1.55) 1.09 ( 0.59- 2.03) 1.11 ( 0.69- 1.79) 1.16 ( 0.68- 1.98) 13<S3CU<26 3 21 0.27 ( 0.07• 0.98) 0.23 ( 0.05- 1.09) 0.14 ( 0.02- 1.12) 0.29 ( 0.08- 1.06) 0.28 ( 0.06- 1.34) 25<S3CU S 2.63 ( 0.60•11.45) 1.78 ( 0.34- 9.42) 1.78 ( 0.33- 9.47)~ 3.01 ( 0.67-13.60) 2.92 ( 0.25•34.74) EXC1 udld/TreRd 15 32 0. 92 ~ 0.92 0.89 ) 0.92 0.92 AGE 55-G4 YEARS Non OXpozetl ' 80 534! 1.00 e 1.00 1.00 E 1.00 1.00 0<S3CU<e13 1 59 151 0.83 ( 0.51- 1•34) 0.76 ( 0.46- 1.27) 0.52 ( 0.28- 0.95) 0.84 ( 0.52- 1.37) 0.78 ( 0.44- 1.40) 13<S30U<.26 17~ 29 1.26 ( 0.60- 2.63) 0.89 ( 0.40- 1.98) 0.48 ( 0.18- 1.26) 1.24 ( 0.59- 2.61) 1.15 ( 0.46- 2.85) a5<S3CU ~ 12 16 1.74 ( 0.72- 4.22) 1.44 ( 0.57- 3.66) 1.09 ( 0.38- 3.13) 1.71 ( 0.70- 4.15) 1.79 ( 0.64- 5.02) EXC1Udrd/Trond, ~ 42 722 0.12 0.12 0.10 0.12 0.1 2 i AGE ®S+ YEARS Non exposetl 90 238 1.00 1.00 1.00 7.00 t 7.00 0<S3CU<13 76 169 0.99 ( 0.66- 1.48) 1.09 ( 0.71- 1.67) 1.18 ( 0.69- 2.02) 0.99 ( 0.66- 5.49) 1.01 { 0.64- 1.58) 13<S3CU<28 21~ 36 1.29 ( 0.67• 2.47) 1.21 ( 0.60- 2.45) 0.90 ( 0.38- 2.15)' 1.38 ( 0.71- 2.66) 1.03 ( 0.49- 2.15)I 25<S3CU 21 37 1.19 ( 0.63- 2.26) 1.30 ( 0.67- 2.52) 1.25 ( 0.57- 2.72)~ 1.21 ( 0.64- 2.30)~ 0.89 ( 0.42- 1.85)~ Ezcludad/Trend I 67 749 0.44 t 0.44 0.40 0.42 0.44 HI Non axpo:ad 245 663 t.00 1.00 1.00 1.00 1.00 0<53CU<13 188 432 0.93 ( 0•72• 1.20) 0.92 ( 0.70• 1.21) 0.96 ( 0.69- 1.32) 0.95 ( 0.73- 1.23) 0.96 ( 0.72- 1.28) 13<53CU<25 40 86 1.01 ( 0.65- 1.57) 0.91 ( 0.57- 1.48) 0.62 ( 0.35- 1.11) 1.06 ( 0.68- 1.65) 0.91 ( 0.55- 1.53) 25<S3CU 36( 58 1.29 ( 0.80- 2.09) 1.20 ( 0.72- 2.00) 1.14 ( 0.65- 1.99)1 1.32 ( 0.82- 2.14) 1.16 ( 0.66- 2.04) c'xcludPd/Trend 11ei 303 0.27 0.27 0.28 1 0.27 0.28 TOLOGICALLY CONFIRMED DIAGNOSIS SOUAMOUS CELL CARCINOMA Non expoaed 42 663 1•00 1.00 1.00 , 1.00 1.00 OeS3CU<.13 33 432 9 0.91 ( 0.53- 1.55) 0.76 ( 0.43• 1.37) 0.74 ( 0.38- 1.43) 0.89 ( 0.52- 1.54) 0.66 ( 0.35- 1.24) 13<S3CUu25 9 86 1.28 ( 0.55- 2.98) 0.78 ( 0.28- 2.19) 0.32 ( 0.07- 1.46) 1.30 ( 0.56- 3.04) 0.61 ( 0.19- 1.94 ) 25<83CU 4 58 0.87 (, 0.28- 2.73) 0.61 ( 0.17- 2.17) 0.63 ( 0.17- 2.36) 0.87 ( 0.28- 2.72) 0.43 ( 0.09- 2.01) Exc1ud.d/Trend 2j 303f 0.90 0.90 - 0.86 0.89 t 0.90 SMALL CELL CARCINOMA Nan expazed 27 663 1.00 1.00 1.00 1.00 1.00 0<S3CU<e13 1a 432 1.01 ( 0.51- 2.02) 0.97 ( 0.47- 1.99) 1.16 ( 0.54- 2.50) 1.06 ( 0.52• 2.13) 1.11 ( 0.55- 2.26) 13<S3CU<.26 6 86 1.88 ( 0.67• 5.27) 1.52 ( 0.50- 4.61) i 1.44 ( 0.42- 4.91) 1.94 ( 0.69- 5.47) 1.67 ( 0.55- 5.08) 25<S3CU 2 58 0.73 (, 0.15• 3.46) 0.69 ( 0.14- 3.30) 0.92 ( 0.18- 4.54) 0.73 ( 0.15- 3.45) 0.37 ( 0.05- 3.02) ckG2udad/Trend 17 303 0.87 0.93 0.92 0.86 0.88 ADENOCARCINOMA ~ Non expozed 133 663 1.00 1.00 1.00 1.00 1.00 0<S3CU<s13 102 432 0.86 ( 0.63• 1•19) 0.90 ( 0.64• 1.27) 0.88 ( 0.58- 1.33) 0.89 ( 0.64- 1.23) 0.97 ( 0.67- 1.38) 13<S3CU<s25 ~ 18 86 0.79 ( 0.44- 1•42) 0.76 ( 0.40- 1.43) 0.55 ( 0.26- 1.18) 0.84 ( 0.46- 1.50) 0.77 ( 0.39- 1.50) 25<33CU 27 58 1.65 ( 0.96- 2.85) 1.59 ( 0.89- 2.85) 1.46 ( 0.76- 2.79) 1.72 ( 0.99- 2.96) 1.56 ( 0.83- 2.94) i F~c2ud®d/Trend 53 303 0.10 1 0.09 € 0.10 0.10 0.10 ~ OTHER Nan expazad 43 663 1.00 1.00 1.00 1.00 1.00 0<$3CU<~13 35 432 1.04 ( 1.75) 0.62- 0.97 ( 0.56- 1.70) 1.12 ( 0.57- 2.20) 1.12 ( 0.66- 1.88) 1.05 ( 0.57- 1•92) ~ I 13<S3CU<25 7 I 86 1.00 ( 2.43) 0.47- 1.11 ( 0.45• 2.76) 0.73 ( 0.23- 2.34) 1.09 ( 0.45- 2.66) 1.16 ( 0.43- 3.13) 26eS3CU 3 58 ( 0.65 2.31) 0.19- 0.65 ( ~ 0.18- 2.32) 0.51 ( 0.11- 2.36) 0.69 ( 0.20- 2.45) 0.89 ( 0.24- 3.30) Ezcluded/TreRd ~ 27 t 303 0.54 0.54 0.54 I 0.56 0.54 >75% OF LIFESPAN IN RURAL AREA OR INTERMEDIATE CITIES Non exposed 0<53CU<c13 903 64 224 144 1.00 0.75 ( 0.49- 1.17) 1.00 0.75 ( ) 0.49- 1.17)! 1.00 0.57 ( 1 0.33- 0•98)1 1.00 0.73 ( 0.47- 1.14)i 1.00 0.69 ( 0.43- 1.11) 13<S3CU<25 19 26 1.33 ( 0•64- 2.75) 1.33 ( 0.64- 2.75) 0.78 ( 0.30• 2•00) 1.35 ( 0.65- 2.83)1 1.05 ( 0.48• Z 26) 25<S3CU 14 16 1.51 ( 0.64- 3.55) 1.51 ( 0.64- 3.55) 1.39 ( 0.52- 3.68)1 1.54 ( 0.65- 3.63)~ 1.07 ( 0.43- 2.71) EXC10dtd/TrMd 56 766 0.15 0.15 0.13 0.15 0.16 a75% OF LIFESPAN IN URBAN AREA Non exposed 86 0<53CU<13 86 13<S3CU<25 1t 25<S3CU 17 EXC1udOd/Trlnd 44 308 1.0o 1.00 1.00 t . oo 1.00 214 1.09 ( 0.73- 1.61) 1.09 ( 0.73- 1.61) 1.32 ( 0.83- 2.10) 1.05 ( 1. 0.71- 1.57) 1.16 ( 0.73- 1.84) 48 0.64 ( 0.30- 1.37) 0.64 ( 0.30• 1.37) 0.57 ( 0.24- 1.36) 0.66 ( 0.31• 1.42) 0.74 ( 0.31• 1.76) 36 1.31 ( 0.66- 2.59) 1.31 ( 0.66- 2.59) 1.13 ( 0.51- 2.51) 1.28 ( 0.64- 2.53) 1.52 ( 0.67- 3.44) 905 0.79 0.79 0.79 0.80 ---~-- _0..79 __ _ (1) Mode) ineluds sex, center, sex'eenter and age (2) Mode/ inoJude sex. eantet, sax'unter, age and proportton of residential type in the last 35 yrs (REUP) (3) Model indudo sex, csntor, sex'canter, aga, proporGon of rosx.'ential type in the last 35 yrs (REUP) and educational level (EDUC) (4) Model nduda sex, cenlor, sex'unter, age and duration of exposure to list A agents (OCLAY) 2063593428

C_S3AV Spouse and other cohabitants, Average exposure (cigarettes/day) MEN ONLY Lmvat of ex urs Cases Controls OR(1 95% Cl O 2 95% Cl OR(3 95% Cl O _4 95% G OR(5 95% Cl Non exposed ss 394 1.00 1.00 1.00 1.00 1.00 0<53AV<0.61 29 80 1.54 ( 0.88- 2.69) 1.56 ( 0.85- 2.86) 1.64 ( 0.70• 3.86) 1.65 ( 0.94- 2.91) 1.98 ( 1.02- 3.86) 0.61<S3AV<.0.85 3 8 1.72 ( 0.33- 8.96) 1.66 ( 0.26-10.74) 1.58 ( 0.12-20.84) 1.78 ( 0.33- 9.54) 2.13 { 0.29-15.86) 0,85<S3AV 0 4 0.00 ( 0.00•99.99) 0.00 ( 0.00-99.99) 0.00 ( 0.00-99.99) 0.00 ( 0.00-99.99) 0.00 ( 0.00-99.99) Excludad/Trend >f~ 45 0.48 0.51 E 0.51 t 0.46 0.49 WOMEN ONLY Non exposed 0<s3AV<.o.51 0,61<S3AV<0.85 0,85<53AV EXCIOded/Trond POPULATION BASED STUDIES 164 269 1.00 1.00 1.00 1.00 1.00 178 352 0.92 ( 0.70- 1.22) 0.92 ( 0.69- 1.24) 0.86 ( 0•61- 1.22) 0.94 ( 0.71- 1.24) 0.89 ( 0.64- 1.22) 30 7 0.66 ( 0.41- 1.08) 0.57 ( 0.33- 0.98) 0.54 ( 0.30- 0.99) 0.67 { 0.41- 1.09) 0.51 ( 0.29- 0.91) 34 65 1.16 ( 0.71- 1.90) 1.08 ( 0.65- 1.80) 1.09 ( 0.60- 1.98) 1.19 ( 0.73- 1.94) 0.94 ( 0.53- 1.67) ff3 258 0.87 0.87 0.82 0.87 0.90 Non exposed O<S3AV<.0.51 0.51<S3AV<0.85 0.85<S3AV dad/Trend Exclu 163 510 1.00 1.00 1.00 1.00 ; 1.00 122 274 1.03 ( 0.75- 1.41) 1.02 ( 0.74- 5.42) 1.00 ( 0.67- 1.47) 1.05 ( 0.76- 1.45) 1.15 ( 0.80- 1.65) 17 50 0.71 ( 0.38- 1.32) 0.74 ( 0.40- 1.39) 0.69 ( 0.34- 1.43) 0.73 ( 0.39• 1.35) 0.82 ( 0.41- 1.64) 14 29 1.05 ( 0.51- 2.15) 1.07 ( 0.52• 220) 1.04 ( 0.46- 2.36) 1.06 ( 0.52- 2.19) 1.05 ( 0.44- 2.54) 62 87 0.66 0.62 0.60 0.65 0.67 HOSPtTAL ®ASED STUDIES Non exposed 0<53AV<0.51 0.51<S3AVc.0.85 89 153 1.00 1.00 1.00 1.00 1.00 E 85 158 1.04 ( 0.69- 1.57) 0.96 ( 0.59- 1.561 0.86 ( 0.46- 1.60) 1.08 ( 0.71- 1.64) 0.84 ( 0.51- 1.37) 16 35 0.80 ( 0.40- i.59) 0.47 ( 0.19• 1.17) 0.45 ( 0.16• 1.25) 0.81 ( 0.40- 7.62) 0.37 ( 0.15- 0.91) 0.85<S3AV 20 30 1.37 ( 0.71- 2.66) 1.09 ( 0.53• 2.26) 1.17 ( 0.48- 2.85) 1.42 ('0.73- 2.75) 0.88 ( 0.41• 1.90) Ezcluded/Trond 36 76 0.59 0.62 7 0.63 0.59 0.57 WiTHOUT OCCASIONAL SMOKERS Non exposed 186 485 1.00 1.00 1•00 1.00 1.00 <S3AVer0.51 0 153 309 1.11 ( 0.83• 1.50) 1.09 ( 0.79- 1.50) 0.89 ( 0.62- 1.29) 1.13 ( 0.83- L 52) 1.06 f 0.75- 1.50) 0.51<S3AV<0.85 25 67 0.73 ( 0.43- 1.25) 0.55 ( ~ 0.29- 1.01) 0.52 ( 0.27- 1-00) 0.74 ( 0.43- 1.26j 0.48 ( 0.25- 0•94) 0.85<S3AV 24 43 1.15 ( 0.65- 2.04) 1.03 ( 0.56- 1.90) 0.94 ( 0.47• 1.88) 1.17 ( 0.66• 2.08)1 0.84 ( 0.43- 1.67) Exc1 uded/Trend 98 200 0.86 0.86 t 0.79 0.85 [ 0.87 AGE <65 YEARS Non exposed 132 191 1.00 1.00 1.00 1.00 1.00 ~ <S34V<.051 0 . 54 98 1.12 ( 0.70- 1,60) 1.00 ( 0.59- f.69) 1.09 { 0.58• 2.07) 1.16 ( 0.71- 1.88) 1.21 ( 0.70- 2.?1) 0,61<S3AV<D .85 7 21 0.66 (, 0.25- 1.74 ) 0.54 ( 0.16- 1.78) 0.67 i 0.19• 2.35) 0.70 ( 0.26- 1.87) 0.76 ( 0.22- 2.62j 0.85<S3AV 7 191 0.72 ( 0.27- 1.91) 0.48 ( 0.16• f.44) 0.64 ( 0.18- 2.31) 0.77 { 0.29- 2.04) 0.53 ( 0.16• 1.81)1 Exc1 uded/Trend 15 32 0.37 0.0 4 0.31 0.37 ( 0.37 AGE 65•S4 YEARS Non exposed 80 234 1.00 1.00 1.00 1.00 1.00 0 <S3AV<.0.61 64 150 0.91 ( 0.57- 1.47) 0.84 1 0.51• 1.39) 0.55 ( 0.30- 5.01) 0.93 ( 0.57- 1.50) 0.91 ( 0.51- 1.62) O,bi<83AV<0.85 12 32i 0.74 ( 0.33. 1.67 ) 0.45 ( 0.16- 1.16) 0.34 ( 0.12- 0.95) 0.73 ( 0.33- 1.65) 0.58 ( 0.22- 1.54) 0.85 <S3AV 121 i4 1.99 ( 0.81• 4.92) 1.77 ( 0.69- 4.50) 1.55 ( 0.46- 5.22) 1.96 ( 0.79- 4.84) 1.71 ( 0.61• 4.76) Excluded/Trend 42 122 l 0.36 0.37 0.39 ( 0.38 0.35 AGE 65+YEARS Non exposed 90 238 1.00 1.00 1.00 1. 00 1.00 0<S3AV<0,51 89 184 1.07 ( 0.72- 1.59) 1.15 ( 0.76- 1.75) 1.17 { 0.69- 1.97) 1.09 ( 0.73- 1.62) 1.08 ( 0.70- 1.68) 0,51<S3AV<0.85 14 32 0.81 ( 0.39• 1.65) 0.85 ( 0.41- 1.80) 0.78 ( 0.31- 1.94) 0.81 ( ~ 0.40- 1.67) 0.60 { 0.27- 1.33) <S3AV 0,85 i 15 f 26 1.35 ( 0.64- 2.84) 1.43 ( 0.66• 3.08)~ 1.52 ( 0.64- 3.60) 1.35 ( 0.64- 2.84) 1.01 ( 0.41- 2.44) E,rcludod/Trend + 67 149 0.70 0.7f t 0.71 0.70 ~ 0.68 HISTOLOGICALLY CONFIRMED DIAGNOSIS Non exposed 0<S3AV<0.51 0,51<S3AV<0.85 0,85<S3AV Exc1 uded/Trend SQUAMOUS CELL CARCINOM A 2451 199( 33I 32 118 6fi3( 1.00 432i 0.99 ( 85I 0.73 ( 59 1.15 ( 3031 0.89 0.77• 0.46- 0.71• 1.28) 1.16) 1.89) 1.00 0.99 0.63 1.07 0.89 Non exposed 42 663 1.00 1.00 0<S3AV<0.51 32 432 0.89 ( 0.52- 1.53) 0.76 0,51<S3AV<0,85 9 85 1.15 ( 0.50- 2.67) 0.59 0.85<S3AV 5 59 1.19 ( 0.42- 3.34) 0.88 Excluded/Trend 2' 1 303 0.64 0.63 SMALL CELL CARCINOMA Non exposed 0<S3AVc0.51 0.51<S3AV<0.85 0.85<S3AV Exc1 uded/Trend ADENOCARCINOMA 1.00 1.18 0.51 0.66 0.41 ( 0.75- 1.30) ( 0.38- 1.05) ( 0.64• 1.80) ~ 1.00 0.97 ( 0.70- 1.34) 0.60 ( 0.33- 1.06) 1.15 ( 0.64- 2.07) 1 0.85 1.00 1.02 0.75 1.18 0.89 f 0.79- 0.47- 0.72- 1.33) 1.19) 1.93) 1.00 1.04 0.61 1.01 0.91 t 0.78- 1.40) 0.35- 1.05) 0.57- 1.79) ( 0.43- f, 0.19- { 0.29• 1.37) 1.78) 2.72) 1•00 0.65 0.71 0.78 0.61 7 ( 0.33- 1.27) ( 0.22- 2.28) ( 0.21- 2.90) 1.00 0.88 ( 0.51- 1.15 ( 0.50- 1.18 ( 0.42- 0.64 ~ 1.00 1.52) 0.69 ( 2.66)~ 0.43 ( 3.34)i 0.47 { tt 0.61 0.37- 0.12- 0.10- 1.30) 1.53) 2.12) 1.00 1 1.00 4 1.00 { 0.59- 2.36) 1.35 ( 0.63- 2.86)1 1.34 ( 0.68• 2.62) 1.36 ( 0.68- 2.69) ( 0.11- 2.36) 0.63 ( 0.13- 3.01) 0.51 (, 0.11- 2.34) 0.26 ( 0.03- 2.02) ( 0.14• 3.12) 0.87 f, 0.18- 4.34)~ 0.71 ( 0.15• 3.35) 0.73 ( 0.15• 3.53) 0.39 0.44 1 0.43 Non exposed 133 663 1.00 1.00 1.00 1.00 100 . 0<S3AV<.D.51 111 432 0.95 ( 0.70- 5.31) 0.99 ( 0.71- 1.40) 0.93 ( 0.62- 1.42) 0.99 ( 0.72- 1.36) 1 .06 ( 0.75• 1.52) 0.51<53AVc.0.83 15 85 0.59 ( 0.32- 1 .08) 0.56 ( 0.28- 1.09) 0.43 ( 0.19- 6.97) 0.60 { 0.33- 1.12) 0.58 ( 0.29- 1.16 ) 0,85<S3AV i 21 59 1.24 ( 0.70- 2.21)i 1•16 ( 0.64- 2.19) ' 1.40 ( 0.70- 2.77) 1.28 ( 0.72• 2 29) 1.13 ( 0.58- 2.22) EXC10ded/Trend 53 303 0.91 { 0.92 ( 0.89 0.90 0.92 OTHER Non exposed 43 663 1 .00 0<83AV<0,51 34 432 1.02 ( 0.61- 0,51<S3AV<0.85 7 85 0.96 ( 0.40- 0,85<S3AV 4 59 0.91 ( 0.30• ~ EXC10ded/Trtnd 27 1 303 1 0.86 s757G OF UFESPAN IN RURAL AREA OR INTERMEDIATE CITIES Non exposed 0<S3AV<0.51 0,61<S3AV<0,85 0,85eS3AV Exc1 uded/Trend a7696 OF UFESPAN IN URBAI Hon exposed 1.00 0.89 (- 0.58- 0.48 ( 0.20- 1.50 ( 0.66- 0.90 I 1.72) 2.32) 2.76) 1.00 0.98 ( 0.91 ( 0.89 ( 0.83 0.56- 0.35• 0.29• 1.72) 2.36) 2.75) 1.00 1.05 ( 1.01 ( 0.58 ( 0.82 0.53- 2.08) 0.35- 2.92) 0.13- 2.66) 1.00 1.11 1.01 0.95 0.87 ( 0.65- ( 0.42- ( 0.31• 1.88) 2.45) 2.90) 1.00 1.03 ( 1.06 ( 1.17 ( 0.85 0.56- 0.40- 0.37- 1.91) 2.82) 3.72)~ ( 1.00 1 1.00 1•00 ( 1.00 1.37) 0.89 ( 0.58- 1.37) 1 0.63 ( 0.37- 1.09)1 0.86 1 0.56- ) 0.81 ( 0.51- 1.28) 1.15) 0.48 ( 0.20- 1.15) 0.41 { 0.16- 1.07}i 0.48 /, 0.20- 1.15) 0.43 ( 0.18- 1.04) 3.44) 1.50 ( 0.66• 3.44) 1.95 ( 0.65- 5.86) 1.54 ( 0.67• 3.54) 1.07 ( 0.42- 2.73) 0.90 0.91 : 0.91 0.89 86 308 1.00 1.00 1.00 1.00 1.00 0<S3AV<.0.61 89 221 1.10 ( 0.74- 1.63) 1.10 ( 0.74- 1.63) 7.28 ( 0.80- 2.03) 1.08 ( 0.73- 1.62) 0.75- 1.90) 7.20 0.51<S3AV<0,85 11 44 0.69 ( 0.33• 1.45) 0.69 ( 0.33- 1.45) 0.63 ( 0.27- 1.50) 0.64 { 0.30- 1.37) 0.73 { 0.31- 1.71) 1 0.85<S3AV 14 331 1.19 ( 0.58- 2.46) 1.19 ( 0.58- 2.46)1 1.22 ( 0.54- 2.77) 1.14 ( 0.55• 2.35) 1.37 ( 0.58• 3.20) ExClOded/Trbnd 44 105 0.97 0.97 0.96 0.87 0.96 ~ (1) Model include sox, center, sex'oenter and age (2) Model include sex, center, sex'canter. age and proportion of residential type in the last 35 yrs (REUP) 2-3) M~a) Uletuda sax, center, sex'center, age, propotfion of residential type in the last 35 yrs (REUP) and educational level (EDUC) .. _.- ~ fi1.?.J7J`'1•ti0G (4) Model Inc(udm sex, canter, sex'center, age and duration of exposure to I st A agents (OCLAY)

~~~ Risk estimates - Spouse and workpiace

S3UD Spouse and other cohabitants, Duration (years) (non overlapping) 17ALY 2 Total Exoosed Unexoosed Excluded Min E P10 ~ 01 1 Median 03 P90 { Max Mean Std ~ ! MCn CaSC3 3 0 3 0 € COntt0lf 97 21 74 2 4.00 8.00 9.00~ 16.00 26.00 € 40.00 43.00 18.71~ 11.96~ All 100 21~ 77 4.00 8.00 9.00 16.00 26.00 40.00 43.00 18.71 11.96 WO(Mn CASCS 16 8 7 t 7.00 7.00 22.50I 30.50 34.50 42.00 42.00 28.00 10.771 Controls 76 50 21 5 4.00 8.50 19.00 If 31.50 36.00 41.50 51.00 27.80 12.161 All 92 58 28 6 4.00 7.00 ' 20.00 31.50 35.00 42.00 51.001 27.83 11.89 Ak C8sC3 19 8 10 1 7.00 7.00 24°.50 30.50 34.50 42.00 42.00 28.00 10.77 Conlr~s 173 71 95 7 4.00 5.00 13.00~ 28.00 35.00 41.00 51.00~ 25.11! 12.72 AII 192 79 105 8 4.00 7.00 14.00 28.00 35.00 41.00 51.00! 25.41f 12.51 ITALY 3 MOn C35CS 1 1 0 0 11.00 11.00 11.00 11.00 11.00 /1.00 11.00 11.00 0.00 ~~ ~ ~ ~ ~ ~ AJ 13 4 91 0 2.00 2.00 6.50 12.00 20.50 28.00 28.00 10.79 13.50 WonSCn CisCS 15 11 3 1 12.00 16.00 21.00 31.00 44.00 44.00M 49.00 31.18 12.53 Controls 38 23 13 2 2.00 19.00 26.00 32.00 38.00 47.00j 50.00 31.52~ 12.45 A11 53 34f 16 3 2.00 16.00 24.00 31.50 42.00 47.001, 50.00 ~ 31.41~ 12.28 All F.isC3 16 12 3 1 11.00 12.00 18.50 28.00 43.00 44.00 49.00 29.50 13.29 ContlDlf 50 26 22 2 2.00 5.00 ~ 21.00 31.00 38.00 47.00 50.00 29.54 13.47 ~ A11 66 38 25 3 2.00 11.00 21.00 31.001 38.00 47.00 50.00 13.23 29.53 PORTUGALI Men Ca503 16 6 10 0 4.00 4.00 10.00 18.50! 30.00 31.00 31.00 18.67 10.73 Controlb ~ 8 1 7 0 28.00 28.00 28.00 28.001 28.00 f 28.00 28.00 28.00 0.00 AI! 24 7 17 0 4.00 4.00 10.00 20.001 30.00) 31.00 31.00 20.00 10.41 WOlnOt1 COSCS I 33 23 10 0 2.00 9.00 15.00~ 32.00 39.00 43.00 46.00f 27.70 12.78 Controls 31 19 10 2 5.00 11.00 19.00) 26.00 29.00 39.001 42.00i 24.74 8.84 All 64 42 20 2 2.00 11.00 19.00 27.00 36.00 ! 39.001 46.00 26.36~ 11.14 All Cases 49 29 20 0 2.00 8.00 15.00~ 27.00 37.00 43.00 46.00 25.83 12.76 Controls 39 20 17 2 5.00 14.001 19.501 26.50 29.00 36.00f 42.00 24.90 8.63 A!1 88 49 37 P 2.00I 9.00 19.001 27.00 33.00 39.00f 46.00 25.45 11.16 PORTUGAL2 Men Casos l0 0 10 0 ~ Controls 17 6 11 0 1.00I ':.00 4.00 6.00 10.00 40.00 40.001 11.17 14.44 All 27 6 21 0 1.00f 1.00 4.00 6.00 10.00 40.00 40.00 ?1.17 14.44 Women Cases 23 18 3 2 3.00 3.00 19.00 28.50 39.001 46.00 48.00 27.72 13.79 Controls 36 ;7 19 0 1.00 5.00 11.00 20.00 29.00~ 37.00 42.00 19.88~ 12.04 All 59 35 22 2 1.00 5.00 12.00 23.00 36.00 41.00 48.001 23.91' 13.38 Afl C2Sp3 33 18 13 3.00 3.00 19.00 28.50 39.00 46. 00 48.00 27.72 13.79 Controls 53 23 30 0 1.00 4.00 6.001 14.001 29.001 37.00 42.00 17.61 12.96 All 96 41 43 1.00 4.00 10.001 20.00~ 34.00 41.00 48.00 22.05 14.11 SPAlN Men Cases 6 2 3 1 4.00 4.00 4.00 17.50 31.00 31.00 31.00 17.50 19.09 CCntrol3 ~ 13 2 '1 0 7.00 7.00 7.00 12.50 18.00 18.00 18.00 12.50 7.78 All 19 4 14 1 4.00 4.00 5.50 12.50 24.50 31.00 31.00 15.00 12.25 WoR1Ct1 CiSCS 65 36 16 13 1.00 7.00 ',3.50 27.50 36.00 45.00 60.00 26.36 14.70 ConlroiS 146 99 24 23 ;.00f 6.00 18.00f 30.00 40.00 45.00 56.00 28.41 14.11 All 211 135 40 36 .00I 7.00 16.00f 30.00 39.00 45.00 60.00 27.87 14.24 AU 0955s 71 38 19 14 1.00}~ 4.00 13.00 27.50 36.00 45.00 60.00 25.89 14.77 ControlS 159 101 35 23 1.001 7.00, 18.00 30.00 40.00! 44.00 56.00 28.10 14.16 AIl 230 139 54 37 1.00~ 6.00 15.00 30.00 38.001 45.00 60.00 27.501 14.31 SWEDEN Men Cases 23 t2~ ~1 0 1.00 1.00 2.50 9.00 23.50 34.00 44.00 14.00 14.76 CONro!f 36 ?1 5 01 1.00 2.001 4.00 8.00 19.00 22.00 29.00 11.091 9.14 All 59 23 36 0 1.00 1.00~ 3.00 8.00 19.00 31.00 44.00 12.61) 12.21 WOrnCn CaSCS 47 25 1 1 1.00 2.00 4.00 18.00 32.00 34.001 48.00 19.16 14.23 Controls 76 49 27 0 1.00 3.00~ 6.00 17.00 29.00 38.00 52.00 18.96 14.10 All 123 74 48 1 1.00 3.00 5.00 17.50 30.00 35.00 52.00 19.03 14.05 AIl CisCS 70 37 32 1 1.00 2.00 4.00 14.00 31.00 34.00 48.00 17.49 14.41 ConltolS 112 60 52 0 1.00 2.50 5.00 16.00 27.50 35.00 52.00 17.52 13.61 All 182 97 84 1 1.00 2.00 4.00 16.00 29.00 35.00 52 00 17.51 13.85 UNITED KINGDOM Men CaSC4 3 1 2 0 10.00 10.00 10.00 10.00 10.00 10.00 10.00 10.00 0.00 Controls 14 3 11 0 40.00 40.00 40.00 43.00 43.00 43.00 43.00 42.00 1.73 All 17 4 13 0 10.00~ 10.00 1 25.00 41.50 43.00 43.00 43.00 34.00 16.06 WOR1C0 C.i5C9 ! 23 17 6 0 2.00 2.00 11.00 39.00 31.00 43.00 49.00 27.71 15.52 Controls I, 126 83 43 0 3.00 10.00 19.00 ~ 27.00 38.00 45.00 49.00 27.51 12.41 AH 1 9 100 49 0 2.00 10.00 19.00 1 28.50 38.00 45.00 49.00 27.54 12.90 All 4 CasCY I 6 18 8 0 2.00 2.00 10.00 30.50 39.00 43.00 49.00 26.72 15.62 Contr0ls 140 ~ 86 54 0 3.00~ 10.00 19.00 28.00 39.00 45.00 49.00 28.01 12.48 Atl 166 104 62 0 2.00! 10.00 19.00 29.00 39.00 45.00 49.00 27.79 13.00 2063593440

E_Q3TP Spouse and other cohabitants, exposure to different tobacco products ALL CENTERS Lw.l of exnosure Non exposed Only pigarette Never cigerette Cigarette + other &cludid/Trandl 981 114 OR(1) 95% Ck 1.00 1.07 ( 0.85- 1.34) 0.68 ( 0.31- 1.46) 1.18 ( 0.77- 1.80) ALL CENTERS WITH EDUCATIONAL LEVEL AND TYPE OF RESIDENCE Non exposeo only cigarette Never ciqarette Cigarette + othor c"xcludad/Trand ALL CENTERS WITH DIETARY DATA Non .Xposeo Only ciQarotte Never cigarette OiOarette + other Fxcludad/Trend FRANCE Non exposeo only oigarette Never cigarette Cigarette + other Exclt.dad1r/'snd 539 430 25 56 288 1.00 0.40 ( 0.13- 1,27) 0.00 ( 0.00-99.99) 0.00 ( 0,00•99,99) 200 460 1.00 1.00 1.00 k 1.00 1.00 211 378 1.05 ( 0.80- 1.37) 1.06 ( 0.80- 1.41) 1.07 ( 0,77 1.48) • 1.06 ( 0.80- 1.39) 1.04 { 0.79- 1.36) 10 25 0.71 ( 0.32- 1.55) 0.50 ( 0.21- i.23) 0.60 ( 0.24 • 1.50) 0.79 ( 0.36- 1.75) 0.72 ( 0.33- 1.58) 46 65 1.24 ( 0.79- 5.94) 1.26 ( 0.79- 1.99) 1.15 ( 0.67- 1.97) 1.23 ( 0.79- 1.93) 1.25 ( 0.80- 1.96) 42 1281 34 49 1.00 1.00 1.00 1.00 1.00 35 82 0.63 ( 0.33- 1.20) 0.46 ( 0.22• 0.96) 0.40 1 0.15- i.08) 0•60 ( 0.31- 1.16) 0.61 ( 0.32- 1.16 ) 3 4 1.08 ( 0.22- 5.37) 0.21 ( 0.02• 2.23) 0.28 ( 0.02- 3.60) 1.06 ( 0.21- 5.31) 0.98 ( 0.19- 4.99) 5 16 0.47 ( 0.15- 1.47) 0.30 ( 0.08- 1.11) 0.25 ( 0.04- 1.47) 0.46 (-0.15• 1.45) 0.46 ( 0.15- 1.45) 0 0 ( ( GERMANYI Non exposed Only cigarette Never cigarette Ciqaretto + other 26 138 1.00 1.00 1.00 1.00 ` 1.00 32 67 2.01 (, 1.05- 3.85) 2.11 ( 1.03- 4.32) 2.01 ( 0.97- 4.14)1 2.12 (, 1.09- 4.13) 2.23 ( 1.14- 4.34) 3 5 2.62 ( 0.53-12.88) 2.80 ( 0.55-14.14) 2.55 ( 0.51-12.82) 4.04 ( 0•77•21,29) 2.87 ( 0.59-13.99) ~ 12 19 1.75 ( 0.70- 4.35) 1.93 ( 0.72- 5.16) 1.94 ( 0.72- 5•22)l 1.66 ( 0.65- 4.24) 1.86 ( 0.74- 4.70) Excludad/Tr and ' 3! 0 ) GERMANY2 Non expos00 60 91 1,00 1.00 1.00 1.00 1.00 Only CiQarOttO 69 55 1.28 ( 0.74- 2.22) 1.22 ( 0.70- 2.12) 1.15 ( 0.65- 2.03) 1.28 / 0.74- 2.21) 1.25 ( 0.72- 2.17) Na ver cigarette 3 5 0.56 ( 0.12- 2.53) 0.33 ( 0.06- 1.86) 0.35 ( 0.06- 2.00) 0.55 ( 0.12- 2.53) 0.56 ( 0.12- 2.56) + other Cigarette 9 11 0.82 { 0.30- 2.24) 0.77 (, 0.28- 2.11) 0.70 { 0.25- 1.95) 0.81 ( 0.30- 2.22) 0.83 { 0,30- 2.25) Exc1 adad/Tnsnd f s ( GERMANY 3 Non exposed 21 31 1.00 1.00 1.00 1.00 1,00 Only Cigarette 7 17 0.6] ( 0.20- 9.88) 0.61 1 0.19- 1.93) 0.39 ( 0.11- 1.35) 0.48 ( 0.14- 1.61) 0.58 ( 0,18- 1•83) Novar cigarette 1 3 0.53 ( O.DS- 6.0a) 0.43 ( 0.03• 6.28) 0.27 ( 0.02- 4.92) 0.64 ( 0.05- 7.77) 0.34 ( 0,03• 4•11j CiqarOtt• + OthOr 2 1 3.15 ( 0.24-40.75) 3.16 ( 0.22-44.96) 1.50 ( 0.10-22.83) 3.66 ( 0.27-49.90) 2.00 ( 0.15-27.43) ~rcluded/Trsnd 0 0 ( Non expo50tl 14 103 1.00 1.00 1.00 1.00 Only Cigaratt0 24 110 0.99 ( 0.45- 2.18) 1.25 ( 0,55• 2,85) 1.17 ( 0.51- 2.71) 1.27 ( 0.55- 2.92) 1 Ne 0 ver cigarette t 0.00 ( 0.00•99,99) 0.00 ( 0.00-99.99)] 0.00 ( 0.00-99.99) 0.00 ( 0.00-99.99) qarotto + OthOr I 2 C i 6 1.12 ( 0.19- 6.52) 1.49 { 0.25- 8.98) 1.33 ( 0.22• 8.06) 1.37 ( 0.23- 8.16) c`xcl udod/ Tnand 8 ~ 11 p t ~ ITALY 2 Non exposed Only cigarette Never cigarette Cigarette + other .xcluded/Trand ITALY 3 10 a 0 0 r 95 69 2 Non exposed 3 22 Only cigaratte 12 27 1.00 2.80 ( 0.59-13.28) ORIZ 95% CI OR(3) 95% Ck ) OR(a 95% Ck OR(5) 95% Cr ) 1.00 1.00 ` 1•00 1•00 1.05 ( 0.82- 1.35) 1,03 ( 0.77- 1.39)~ 1.09 ( 0.86- 1.38) 1.04 (- 0.79• 1•36)~ 0.47 ( 0.20- 1.13) 0.54 ( 0.22- 1.33) 0.76 ( 0.35- 1.65) 0.72 ( 0.33- 1,58) 1.19 ( 0.77- 1.84) 1.12 ( 0.68- 1.87) 1.1 s ( 0.78- 1.82) 1.25 ( 0.80- 1.96) 1.00 0.30 ( 0.08- 1.05) 0.00 ( 0.00-99.99) 0.00 ( 0•00•99.99) 1.00 1,00 0.23 ( 0.04- 1.21) 0.38 ( 0.12- 1.211 0.00 ( 0.00-99-99) 0.00 ( 0.00-99.99) 0.00 ( 0.00•99-99) 0.00 ( 0.00-99.99) 1 1.00 2.57 (, 0.53-12.61) cxcludad/Trend( f( fl PORTUGALI Non axposeo ; 20 17 1.00 Only cigarette I 29 201 1.59 ( 0.60- 4.22) r"xcludad/Trend( v( 21 PORTUGAL2 Non eXposetl 13 30I 1,00 Only ciqarette 19 221 2.84 ( 0.98- 8.26) Cigarette + other 0( 1I 0.00 ( 0.00-99.99) fxcl uded/Tr~ond SPAIN Non exposed Only cigarette Never cigarette Cigarette + otner Bxc1 uded/Trand SWEDEN Non exposed i Only cigarette ( Never cigarette Cigarette + other f;rc1 udad/Trand UNITED KINGDOM Non exposedi 19 31 0 8~ ' 13 32 28 0 10 0 35 89 9 20 52 49 2 9 0 1.00 ) 2•21 ( 0.68- 7.24)~ 0.00 ( 0.00-99.99) 1.00 1.00 1.03 ( 0.77- ].39)~ 1.07 ( 0.80- 1.44) 0.54 ( 0.22- 1.3 3) 0•60 ( 0.24- 1.50) 1.12 ( 0.68- 1.87) 1.12 ( 0.67- 1.86) 1•00 1.43 ( 0.24- 8.44) ( 1.00 •00 0.58 (, 0.27- 1.22) 10.65 ( 0.28- 1.48) 0.00 ( 0.00-99.99) 0.00 ( 0.00-99.99) 1.47 ( 0.46• 4,70)+ 1.49 ( 0.45- 4.95) 1.00 1.05 ( 0.54• 2.04) 0.00 ( 0.00-99.99) 2.24 ( 0.76- 6.58) 1.00 0.63 ( 0.27- 1-52) 0.00 ( 0.00-99.99) 1.50 ( 0.44- 5.13) 1.00 2.52 ( 0.51•12.37) 1.00 1.71 ( 0.62- 4.70) 1.00 2.83 ( 0.96- 8.29) 0.00 ( 0.00-99.99) 1-00 0.58 ( 0.27• 1.26) 0.00 t 0.00-99.99) 1.49 ( 0.46- 4.80) 1.00 1,03 ( 0.52- 2.02) 0.00 ( 0.00•99.99) 2.17 ( 0.73- 6.42) 1.00 1•07 ( 0.54• 2.09) 0.00 ( 0.00•99.99) 2.27 ( 0.77- 6.67) 1.00 5.33 ( 0.80-35.70) 1•00 0.54 ( 0.25- 1.18) 0.00 ( 0,00-99.99) 2.01 ( 0.59- 6.79) I 1-00 1.02 ( 0.52- 1,99) 0.00 ( 0.00-99.99) 2.45 ( 0.82- 7.32) 1 a 54 1.00 1.00 1.00 1.00 1.00 Excludsd/Trond 18 86 (1) Modo( ksc(ude sex, center, sax'center and age jZ) Mode)Yxlude sex, center, sex•center, eoe and proportion of residential type in the last 35 yrs (REUP) (3) Modok tnGude sox, center, sex-conter, aga, proportion~ oi residential type in the last 35 yrs (REUP) and educational level (EDUC) (4) Modal Inetudo sex, center, sax'centar, age and duration of exposure to list A agents (OCLAY)

S1CS Spouse, Cumulative exposure of smoking spouse (packs/day x years) FdSTOLOGICALLY CONFIRMED DIAGNOSIS Total Exnosed Unexposed Exduded Mon Casoi 110 18 92 0 Min P10 01 Median ~ 03 P90 Max I Mean Std 0.25 1.00 3.20 9.13 18.00 30.00 33.00 11.71 10.18 Controls 487 59 426 2 0.25 1.25 2.40 6.00 19.00 ~ 30.00 48.00 11.43 11.81 All 732 77 5/8 137 0.25 1.00 2.50 6.50 18.00 11 30.00 48.00 11.49 11.39 C9SC3 Wort1Cn ~ 378 191 151 37 0.10 3.00 9.50 23.00 38.20 ~ 62.00 135.00 ~ 27.40 23.45 Controls 814 460 311 43 0.15 2.90 7.681 21.00 36.63 54.00 336.00 26.15 26.11 All ~ 1807 651 462 494 0.10 3.00 8.50 21.50 37.SOI 55.50 336.00 26.52 25.35 AA CB+CS 683 209 243 231 0.10 2.20 8.25 21.00 37.00 62.00 135.00 26.05 23,03 Conlrols 1656 519 737 400 0.15 2.00 6.50 19.00 35.00 52.00 336.00 24.48 25.33 Atl 2339 728 980 631 0.10 2.10 6.95 19.10 35.38 53.25 336.00 24.93 24.68 MCn CiSC3 19 1 18 0 30.00 30.00 30.00 30.00 30.00 30.00 30.00 30.00 0.00 Controls 407 59 426 2 0.25 1.25 2.40 6,00 19.00 30.00 48.00 11.43 11.81 AII 606 60 444 104 0.25 1.30 2,45 6.00 19.00 30.00 48.00 11.74 11.95 Woman CasCi 68 34 23 11 0.10 2.20 4.20 23.85 37.00 66.201 78.00 25.29 21.70 Controls 614 460 311 43 0.15 2.90 7.68 21.00 36.63 54.0011 336.00 26.15 26.11 AIl 1173 494 334 345 0.10 2.70 7.50 21.00 37.00 54.00 L 336.00 26.09 25.81 Nt C35M 125 35 41 49 0.10 2.20 4.20 24.30 37.00 66.20 78.00 25.42 21.40 Controls 1656 519 737 400 0.15 2.00 6,50f 19.00 35.00 52,00 336.00 24.48 25.33 A!l 1781 554 778 449 0,10 2.10 6.50f 19.00 35.00 52.00 336.00 24.54 25.08 SMALL CELL CARCINOMA MEr1 CSSM 6 2 d 0 4.65 4.65 4.65 I 12,68 20.70 20.701 20.70 12.68 11.35 Controls 487 59 426 2 0.25f `:.25 2.40 ~ 6.00 19.00 30.00 48.00 11.43 11.81 All ! 594 61 430 103 0,25 1.35 2.50 6.00 19.00 27,75 48.00 11.47 11.71 WotriCn Cisos 40 20 18 2 0,15 0.90 8.35 18.35 37.75~ 47.58 135.00 26.72 30.22 Controls 814 460 311 43 0.15 2.90 7.68 21.00 36.63 54.00 336.00 26.15 26.11 All 1143 480 329 334 ~ 0.15 2.75 7.88 21.00 37.00 53.63 336.00f 26.17 26.261 AIt C95o1 81 22 22 37 0.15 1.00 8.00 16.35 37.00 44.00 135.00 25.44 29.14 COnlrOls 1856 519 737 400 0.15 2.00 6.50 ~ 19.00 ~ 35.00 52.00 336.00 24.48 25.331 AU 1737 541 759 437 0.15 2.00 6.60 19.00 35.00 51.75 336.00 24.52 25.46 Men C95CS 60 11 49 0 0.25 1:,00 2,00 11.00 18.00 23.25 33.00 12.11 10.44 CCntrols 487 59 426 2 0.25 1.25 2.401 6.00 19.00 30.00 48.00 11.43 11.81 A!I 680 70 475 115 0.25 1.13 2.40 6.25 18.00 28.88 48.00 11.54 11.54 Women Cases 205 102 85 18 0.15 3.50 11.20 22.75 39.00 62.00 99.00 27.45 22.08 COnIr01s 014 460 311 43 0,15 2,90 7,68 21.00 36.63 54.00 336.00 26.15 26.11 All 1357 1 562 396 399 0.15 3.00 8.50 21.00 37.00 55.00 336.00 26.39 25.41 All ~ Cm3@s Controls ~ 361 1656 113 519 134 737 114 400 0.15 0.15 2.80 10.00 21,00 2.00 6,50 19.00 36.00 35.00! 60.00 99.00 52.00, 336.00 25.96 24.48 21.69 25.33 All 2017 632 871 S14 0.15 2.10 7.00 19.00 35.001 52.501 336.00 24.74 24.71 OTHER MCn Ci:CS 25 4 21 0 1.00 1.00' 2.10 5.60 9.00 10.00 10.00 5.55 4.16 Controls 487 59 426 2 0.25 1,25 2.40 6.00 19.00 30.00 48.00 11.43 11.81 All ~ 610 63 447 100 0,25 1,25 2,40 6.00 16.00 27.75 48.00 '1.05 11.55 WOn10n C35a5 66 35 25 6 0.75 4.35 9.00 22.50 43.90 65.50 103.50 29.69 25.45 COnlrols ~ 914 460 311 43 0.15 2.90 7.68 21.00 36.63 54.00 336.00 26.15 26.11 All 1162 495~ 336 331 0.15 3.00 7.75 21.00 37.00 55.48 336.00 26.40 26.05 AII CiSCS 116 39 ~'48 31 0.75 3.20 6.00 18,90 40.00 65.50 103.50 27.22 25.22 I COntrols 1656 519 737 400'E 0.15'` 2,00 6,50 19.00 35.00 52.001 336.00 24.48 25.33 All ~ 1772 558 783 4311 0.15I 2.10 6.50 19_00 35.00 53.00 336.00 24.67 25.31 >75Y. OF LIFESPAN IN RURAL AREA OR INTERMEDIATE CITIES Men Cases 43 6 37 0 0.25 0.25 1.00 9.60 23.25 33.00 33.00 !2.78 13.54 ContrWs 158 7 150 ?~ 1.00 1.001 1.25 12.30 27.00~ 48.00 48.00 15.76 17.38~ AU 301 13 187 1011 0,25 1.001 1.25 12.30 23.25 33.00 48.00 14.39 15.16 Wort}on C9SOS 131 67 55 9 0.15 1.50 5.00 20.25 38.00 68.00 99,00 25.19 23.82 COnttds ~ 265 ~ A 207 173 319 0.15 2.001 6.13 18.20 36.00 55.00 336.00 25.90 30.84 AIt Cases j 313 73 92 148 0.15 1,00 5,00 19.00 35.00 60.00 99,001 24.17 23.33 Controts 687 147 268 272 0.151 1.80 6.25 17.70 36.00 52.50 336.001 25.74 33.20 ~ AN~ 1000 220 360 4201 0.151 .75 6,00 17.85 35.50 53.25 336.00 25.22 30.24 >759G OF U ESPAN IN URBAN AREA Men Cases Controis AN 41 8 240 38 305 46 33 0 201 1 234 25 1,00 1.00 0.301 1.60 0.30 1.60 4.08 2.50 2.90~ 9.13 14.50 6.00 16.00 6.00 16.00 20.70 27.75I 26.001 20.70 40.00) 40.00 9.64 10.95 10.72 6.90 10.96 10.32 Women C85C3 154 84 ~ 52 18 0,15 4.20 11.65 24.00 39.15 64.50 135.00 29.90 24,78 Controls 4051 250~ 123 321 0.15I 2.90 8.50 22.00 38,00~ 56.50 117.00 26,60 21.61 AIl 8501 334 1751 141 0.15 3.25 10.00 2.25 38.20 60.00 135.00 27.43 22.46 All CmSC4 244 92 85 67 0.15 4.00 10.50 20.85 37.65 62.00 135.00 28.14 24.42 Controls 711i 288 324 99 0.15 2,10 6.83 21.001 35.50 54.00 117.00 24.54 21.18 All 955f 380 4091 166 0.15 2.60 7.38 21.00~ 37.00 56.50 135.00 25.411 22.03 2063593413

S3AV Spouse and other cohabitants, Average exposure (cigan=ttes/day) fTALY 2 Total Exoosed Ur,cxposed Exduded Min P10 ; Q1 Median ~ 03 P90 Max I Mean E 5td ~ M4n CasCS 3 0 3 0 Controls 97 °1 74 2 0.91 2.57 2.93 4.00 6.40 11.43 20.001 5.57 4.51 NI 100 '1 ~ ` 7 . 2 0.91 2.57 2.93 4.00 6.40 11.43 20.00 1 5.57 4.51 WOrtfen C.1.'CS 16 7 7 2 1.50 1.50 2.59 4.00 18.761 40.00 40.00 10.89 14.11 ~~~ 76 411 21 9 0.30 { 3.00 5.23~ 9.291 15.72 33.01 7.29 6.74 9 2 1 53 28 11 0.30 2.00/ 3.00 5.14 9.29 18.76 40.00 '.77/ 7.99 AA COSt3 19 7 10 2 1.50 1.50 2.591 4.00 18.76 40.00 40.00 10.89 14.11 ControlL 173 67 95 11 0.30 2.00 3.00 4.44 8.64 15.38 33.01 6.75 6.15 Aq 192 74 105 13 0.30 2.00 3.00~ 4.37 8.64 15.72 40.00 7.14 7.21 ITALY 3 Men CasC3 1 1 0 0! 3.43 3.43 3.43 3.43 3:43 3.43 3.43 3.43 0.001 COntroIL 12 2 9 1 0.20 0.20 0.20 0.60 1.00i 1.00 1.00~ 0.60~ 0.571 Nt 13 3 9 1 0.20 0.20 0.20 1.00 3.43i 3.43 3.43 1.54~ 1.68 WWnen C25t9 15 9 3 3 2.86 2.86 3.86 5.71 7.86 40.00 40.00 10.06 11.89 Cot1tr013 38 10 13 15 0.75 2.63! 5.57 8.21 11.431 12.23 12.27 7.96 3.91 NI 53 99 16 18 0.75 2.86 4.14 6.431 11.43 15.71 40.00 8.95 8.47 N1 CeSeL 18 10 9 3 2.86 3.07 3.43 4.93 7.86 27.86 40.00 9.401 11.41 Controls 50 12 22 16 0.20 0.75~ 2.75 6.07 11.07 12.19 12.27 6.73 4.55 NI 66 22 25 19 0.20 9.00 3.43 5.71 10.71 12.27 40.00 7.94 8.28 PORTUGALI Men CLSCs 16 6 10 0 1.08 1.08 1.14 ! 1.70 5.00 10.431 10.431 3.51 3.70 Controls 8 1 7 0 1.47 1.47 1.47 ~ 1.47 1.47 1.47~ 1.47! 1.47 0.00 A1! 24 17 0 1.08 1.08 1.14 1.47 5.00 10.43 10.43 3.221 3.46 WOmcn CaSCS 33 21 10 2 0.20 1.39 5.79 10.29 12.86 22.14 30.00 10.79 7.84 Controls 31 17 10 4 0.10 0.11 1.71 4.08 8.57 11.43 12.03 4.72 3.91~ AJI 64 38 20 6 0.10 0.20 2.13 7.14 11.43 20.37 30.00 8.08 7,01 NI C75es 49 27 20 2 0.20 1.14 1.59 9.90 12.86 22.141 30.00 9.17 7.71 Controls I 39 18 17 4 0.10 0.11 1.47 ! 3.82 8.57 11.43~ 12.03 4.54 3.87 All ~ 88 45 37 6 0.10 1.00 1.59 ! 5.79 10.71 14.49 30.00 7.32 6.79 PORTUGAL2 Men Casef 10 0 10 0 , 1 1 I C0rltrol8 NI 17 27~ 4 4 11S 211 2 1 2 1.21 1.21 1.21! 2.39 1.21f 2.39 4.36 5.21 5.29f 4.36 5.21 5.29 5.29 5.29 3.801 3.80 1.85 1 84 WOrTvn C85€S 23 14 3 6 0.64' 1.00 3.001 6.24 10.00 25.09 42.24~ 10.16 11.48 Contr0lL 35 14 19 ~ 3 0.44f 2.00 2.79 5.64 6.57 18.11 20.00 6.46 '_~e AII 59 28 22 9 0.441 i.00 2.89 5.64 8.93 20.00 42.24~ 8.31 9 08 Nt C95e4 Controls All 33 53 88 14 18 32 13 30 43 6 5 11 0.64 0.44 0.44 1.00 3.00 1.21 2.79 1.21 2.89 6.24 10.001 25.09 5.21 1 6.01f 18.11 5.21 7.66 18.57 42.24 20.00 42.24 10.16 5.87 7.75 11 46 5 16 8 631 SPA1N Men Cases 6 2 3 1 3.001 3.00 3.00 3.21 3.43 3.43 3.43 3.21 G 3t I Controls 13 2f 11 0 1.18 1.18 1.18 2. 73 ~ 4.29 4.29 4.29 2.73 2" 1 NI 19 4 14 1 1.18 1.18 2.09 3.21 3.86 111 4.29 4.29 2.97 ~ 31 Women C1L¢L 65 30 16 19 1.29 2.00 2.86 7.04 13.27 20.93 23.16 9.03 =1 Ca+trds 146 83 24 39 0.50 1.18 4.00 6.43 12.86 19.29~ 35.00' 9.06 ' 6: N1 211 113 40~ 58 0.50 .71 3.07~ 6.48 12.86 19.49i 35.00~ 9.05 ` SC NI CJ93CL 71 32 19 20 t- 1.29 2.00 2.86 6.20 13.07 19.98 23.16 8.67 Controls 159 85 35, 39 0.50 1.18 4.00 5.40 12.86 19.29 35.00 8.91 7 55 AII 230 117 541 59 0.50 1.57 3.00 6.40 12.86 19.49 35.00 8.85 7 tb MCn CS,eS 23 12 1 0 0.10 0.10 0.47 2.50 4.51 6.43 14.06 3.46 3.94 ! Controls 35 10 25 1 0.89 0.95 1.29 5.00 10.00 10.71 11.43 5.54 2.9' Atl 59 22 _ 36 1 0.10 0.10 1.00 4.351 6.43 10.00 14.06 4.41 3.98 WMnen CisCL 47 23 21 3f 0.05 0.70 2.00 6.86 8.96 16.58 21.21 7.47 6.2E COntrols 76 48 27 11i 0.05 0.20 1.45 3.85! 8.39 14.00 41.71 6.18 7.39 Ap 123 71 48 4 0.05 0.30 1.79 4.71I 8.87 15.64 41.71 6.60 7.02 All C.isCL 70 35 32 3 0.05 0.101 1.57 4.45 8.57 15.64 21.21 6.10 5.84 Controls 112 58 52 2 0.05 0.29 1.29 4.32 8.57~ 11.97 41.71 6.07 6.89 Atl 182 93 84 5 0.05 0.29 1.57 4.36 8.57 14.00 41.71 6.08 6.48 Men Cases 3 0 0 3 Controls 14 ~ 0 0 14 ~ i AA 17 0 0 17 ! Worncn C3ses 23 0 0 23 ~ Contro(s 126 1 0 0 126 ~ AU 1491 0 01 149 1 ; NI Cascs 25 0 0 26 ~!5 ~ Controls 140 0 0 140 € ~ ~ ~ ~~ ~ All 166 0 0 166 ~ F J1 sVA1 Y yRl_~ ~ aJ.J

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S3TS Spouse and other cohabitants, Time since last exposure (years) MEN ONLY Total Exposed Unexoosed Exduded Min P10 01 ~ Median 03 P90 ~ Max ; Mean Std Men CasC3 157 40 116 1 0.00 0.00 0.00 0.50 14.00 34.00 44.00 8.75 13.5 ConUols 580 124 452 4 0.00 0.00 0.00 2.50 13.00 27.00 43.00 8.20 10.9 All 737 164 S68 0.00 0.00 0.00 2.00 13.00 28.00 44.00 8.34 11.5 Wo mon Cascs 9 0 a ~ ~ Controls 0 0 0 ~ 0 ~ ~ A)I 0 0 0 0 F AN C85CE 157 40 116 1 0.00 0.00, 0.00 0.50 14.00 34.00 44.00 8.75 13.5 Controls 580 124 452 4 1 0.00 0.00 0.00 2.50 13.00 27.00 1 43.00 8.20 90.9 AN 737 164 568 5 0.00 0.00 0.00 2.00 13.00~ 28.00 44.00 8.34 11.5 MU1 C3sC9 0 0 0 0 Controls 0 0 0 0 ~ ttt AN 0 0 f 0 0 I II WOrt1QA CasC3 550 345 183 22 0.00 0.00 0.00E 7.00 18.00 29.00 52.00 10.77. 11.9 Controls 1076 694 35S 27 0.00 0.00 0.00I 6.50 17.00 25.00 50.00~ 9.821 10.6 Afl 1626 1039 538 49 0.00 0.00 0.00+ 7.00 17.00 27.00 52.00 10.14 11.1 AN Cases 550 345 183 22 0.00 0.00 0.00 7.00 18.00 28.00 52.00 10.77 11.9 ~ Controls 1076 694 355 27 0.00 0.00 0.00 6.50 17.00 25.00 50.00 9.821 10.6 AN 1626 1039 538 49 0.00 0.00 0.00 7.00 17.00 27.00 52.00 10.14 11.1 POPULATION BASED STUDIES Men CasCs 91 Controls 444 All 636 28 63 0 0.00 0.00 0.00 3.001 20.50 ~ 39.00 44.00 11.96 15.0 ',01 340 3 0.00 0.00 0.00 3.00 13.00 25.00 43.00 8.10 10.8 129 403 3 0.00 0.00 0.00 3.00 15.00 29.00 44.00 8.94 11.9 WomCtt Cases 287 980 100 0.00 0.00 0.00 9.00 18.50 27.50 44.00 11.52 11.4, Conlras 506 334 170 2 0.00 0.00 0.00 8.00 17.00 27.00 50.00 10.86 11.0. AI1 793 514 270 9 0.00 0.00 0.00 8.50 17.00 27.00 50.00~ 11.09 11.1 - AN C9SCS 378 208 163 7 0.00 0.00 0.00 8.50 19.00 29.00 44.00 11.58 11.9 catuas 950 435 510 5 0.00 0.00 0.00 7.00 ',7.00 27.00 50.00 10.22 11.0. 643 673 12 0.00 0.00 0.00 8.00 17.00 27.00 50.00 10.66 11.3' HOSPITAL ®ASED STUDIES Men C35ef 471 Controls 3 AIl 120 11 35 1 0.00 0.00 0.00 0.00 1.00 3.00 8.00 1.09 2.4 19 54 0 0.00 0.00 0.00 2.00 20.00 27.00 29.00 8.79 11.0 30 89 1 0.00 0.00 0.00 0.00 8.00 24.00 29.00 5.97 9.5 VYOR@n C3SC3 199 130 54 15 0.00 0.00 0.00 3.00 15.00 24.00 52.00 8.92 11.7 Controls I 379 2571 99 23 0.00 0.00 ~ 0.00 4.00 15.00 22.00 46.00 8.04 9.8 All 578 387~ 153 38 0.00 0.00 f 0.00 4.00 15.00 22.00 52.00 8.33 10.5 141l Cases € 246 1411 89 16 0.00 0.00 0.00 3.00 14.00 23.00 52.00 8.31 11.4, Controls ~ 4521 2761 153 23 0.00 0.00 0.04.00 0 1 15.00 22.00 46.00 8.09 9.9: All 598 4171 242 39 0,00 0.00 3.00 0.0 0 15.00 22.00 52.00 8.16 10.4: NITHOUT OCCASIONAL SMOKERS 1MM (.`iSCS 112 28 84 0 0.00 0.001 0.00 2.00 14.001 39.001 44.001 9.29 13.7 Controls 406 84 321 1 0.00 0.00 0.00/ 2.00 13.00 26.001 43.00 7.69 10.4• ~ AN 518 112 405 1 0.001 1 0.00 0.00 2.00 13.00 ~ 27.00 44.00 8.09 11 .3 WOn1Cn COSC9 t 430 267 144 19 0,00 0.00 0.00 6.00 17.00 28.00' S2.00 10.16 11.5 C~11r018 ~ 810 502 282 26 0.00 0.00 0.00 7.00 17.00 26.00 50.00~ 9.98 10.8 All 1240 769 426 45 0.00 0.00 0.00 7.00 17.00 27.00 52.00 10.04 11.0 All C94GS 5421 295 228 19 0.00 0.00 0.00 6.00 16.00 28.00 52.00 10.07 11.7 Controls 1216 586 603~ 27 0.00 0.00 0.00 6.00 16.00 26.00 50.00 9.65 10.8 All 1758 881 831 46 0.00 0.00 0.00 6.00 16.00 27.00 52.00 9.79 11.1 Mtn CBSCS 57 15 42 0 0.00 0.00 0.00 0.00 3.00 9.00 29.00 3.00 7.5 ! CCnlrois '72 38 1331 `: 0,00 0.00 0.00 1.00 10.00 25.00 29.00 6.63 9°' 1 All 229 53 '75 1 0.00 0.00 0.00 0.001 8.00 I 25.00 29.00 5.60 9.1' W=t0 2 0.00 . 0.00 0.00 2.001 13.00 22.00 36.00 6.81 9.2 I Controls 254 139 108 7 0.00 0.00 0.00 1.00 10.00 17.00 27.00 5.28 7.1 All 392 214 169 9 0.00 0.00 0.00 1.00 11.00 19.00 36.00 5.82 7.9 AN Cases 195 90 103 2 0.00 0.00 0.00 1.00 11.00( 21.50 36.00 6.18 9.0 i Controls 426 177 241 8 0.00 0.00 0.00 1.00 10.00 19.00 29.00 5.57 7.7 ~ 6J1 621 287 344 10 0.00 0.00 0.00 1.00 10.00 20.00 36.00 5.78 8.1 AGE SS44 YEARS Men Cases 52 11 41 0 0.00 0.001 0.00 3.00 13.00 31.00 37.00 8.731 13.2 Contras 216 47 167 2 0.00 0.00 0.00 4.00 16.00 28.00 43.00 9.47 11.8 A11 268 58 208 2 0.00 0.00~ 0.00 3.50 13.00 30.00 43.00 9.33 12.0 Wort1~i C~SCS 176 114 54 8 0.00 0.00 0.00 6.00 15.00 27.00 41.00 9.56 11.0 Conlra3 359 245 104 1C 0.001 0.00 0.00 5.001 15.00 25.00~ 42.00 8.90 10.0 All 535 359 158 181 0.00 0,00 0.00 6.00 15.00 25.00 42.00 9.11 10.2 Atl C.iSC2 228 125 95 8 0.00 0.00 0.00 6.00 15.00 28.00 41.00 9.49 11.2 Controls s76 292 iti ?2 0.00 0.00 0.00 5.00 15.00 25.00 43.00 8.99{ 10... ~ All 803 417 366 20 0.00 0.00 0.00 5.00 15.001 26.00 43.00 9.14 10.5 AGE fS+ YEARS MCn Cases ' 48 COntr01s192 All 240 14 39 53 33 152 1851 0.00 0.00 1E 0.00 0.00 ! 0.00 0.00 0.00 0.00 0.00 12.50 22.00 2.00 13.00 3.00 19.00 41.00 29.00 29.00 44.00 37.00 44.00 14.93 8.21 9.98 16.5 10.9 12.8 WCnfCn C95es 236 156 68 12 0.00 0.00 2.00 11.00 21.00 33.00 52.00 13.55 13.1 I Controls 463 310 1431 10 0.00 0.00 2.00 10.50 20.00 30.00 50.00% 12.59 11.6 AN 699 466 211 22 0.00 0.00 2.00 11.001 20.00 32.00 52.00 ~ 12.91 12.1 All Casls I 284 170 101 13 0.00 0.00 2.00 11.00 21.00 34.50 52.00 13.66 13.3 Contras ~ 655 ~ 349EEE 295 I 11 0.00 0.00 1.00 10.00 19.00 30.00 50.00 12.10 11.6 All 939 519 396 24 0.00 0.00 1.00 10.00 20.00 32.00 52.00 12.61 12.2

a:_:s3 I e1; Spouse and other cohabitants, Time since last exposure (years) Cases I Contr ols Non eXposed 260 717 1.00 1.00 15< S3T€ 102 211 1.08 ( 0.79- 1,46) 1.15 ( 0.83- 1.58) 2< S3TS<15 116 274 1.02 ( 0.76- 1,36) 0.99 ( 0.73- 1.33) 0<.S3TS<.2 149 312 1.12 ( ~ 0.85- 1,47) 1.06 r, 0.79- 1.42) €xc1 udtd/Trtnd 23 28 0.03 0.02 ALL CENTERS WITH EDUCA110NAL LEVEL AND TYPE OF RESIDENCE Non exposeo 166 15< S3T8 69 2< S3TS<15 84 0<S3T8<2 93 6xclurfed/Trind~ 86 ALL CENTERS WttH DIETARY DATA 539 1,00 147 1•16 ( 0.80- 1.70) 215 1.02 ( 0.73- 1.44) 234 1.06 ( 0.75- 1.48) 203 0.07 OR(3) 95°G C) OR(4 95% Cf ©R(5) 95% C1 1,00 1.13 ( 0.99 ( 1.03 ( 0.04 . 0.77- 0.70- 0.73- 1.00 1.65)1 1.09 ( 1.40)'t 1.01 ( 1.44)I 1.17 ( 1111 0.03 0.80- 1.49) 0.75- 1.35) 0.89- 1.53)~ 1.00 1.18 ( 0.84- 1.65) 1.00 ( 0.72- 1.39) 1.06 ( 0.77- 1.46) 0.02 1.00 1 1.00 1 1•00 1.13 ( 0.77- 1.65) 1.18 ( 0.81- 1.73) 1.21 ( 0.81- 1.83) 0.99 ( 0.70- 1.40) 0.99 ( 0.70- 1.41) 1.11 ( 0.76- 1.61) 1.03 ( 0.73- 1.44)~ 1.07 ( 0.76- 1.50) 1.09 ( 0.75- 1.57) 0.12 0.08 ~ ~ 0.06 Hon exposen ) ` 200 460 1.00 J 1.00 1.00 1.00 1.00 15< S3TS 99 156 1.18 ( 0.84- 1,65) 1.20 ( 0.85- 1.71) 1.15 ( 0.76- 1.75) 1.19 ( 0.85- 1.68) 1.18 ( 0.84- 1.65) ~ 2< S37S<16 90 193 1.00 ( 0.72- 1,38) 1.00 ( 0.71- 1.40) 1,05 ( 0.72- 1.53) 0.95 ( 0.68- 1.33) 1.00 ( 0.72- 1-39) S3TSt2 b 0< 104 206 1.08 ( ~ , 0.78- 1.48) 1.06 ( 0.76- 1.48) 1.06 ( 0.73- 1.54) 1.12 { 0.81- 1.54) 1.06 ( 0.77- 1.46) dreluded/Trend~ 26 41 0•06 0,06 0•10 0.07 0-06 FRANCE Non e%poSetl 9b< $3TS 2< S3TS<16 0<S37S<2 34 49 1.00 t 1.00 1.00 1.00 1.00 13 30 0.67 ( 0.29- 1,52) 0.49 ( 0.19- 1.26) 0.56 ( 0.16- 1.98) 0.65 ( 0.28- 1.49) 0.62 ( 0.27- 1.45) 14 28 0.76 ( ~ 0.33- 1,75) 0.49 ( 0.19- 1.26} 0.43 ( 0.13- 1.42) 0.69 ( 0.29- 1.61) 0.74 ( 0.32- 1.71) 16 44 0.53 ( 0.25- 7,14) 0.34 ( 0.14- 0.84) 0.23 ( 0.07- 0.81) 0.53 ( 0.24- t.t4} 0.51 ( 0.24- 1.10) fXCluded/7*rtRd 0 0 0.13 E 0.07 0.05 0.11 1 0.11 GERMANYI Non eXpoben 26 138 1-00 1•00 1.00 1 1.00 1,00 ( 15< S3TS 16 28 2.00 ( 0.88- 4,54)( 2.07 ( 0.82- 5.20) 1.88 ( 0.74- 4.77) 2.19 ( 0.94- 5•07)~ 2.30 ( 0•99- 5•33) 2< $3TS<15 1B 35 1.86 ( 0.86• 4.05) 2.27 ( 0.99- 5.22) 2.31 ( 1.00- 5.33) i 1.89 ( 0.85- 4.19)I 2.04 ( 0.92- 4.50) 0<S3TS<2 13 28 2.10 ( 0.90. 4,89)~ 1.93 ( 0.77- 4.83) 1.82 ( 0.73- 4•58) ~ 2.17 ( 0.91- 5•16) 2.21 ( 0.93- 5.23) fYClUded/Trtnd l 31 0 0.01 0.01 0.01 0.01 0.01 Hon eXpoLetl 60 91 1.00 j 1.00 1.00 1.00 1.00 1 23 25 0.95 ( 0.46- 1.95) 0.89 ( 0.43- 1.83)1 0.85 ( 0.41- 1.77) 0.94 ( 0.46- 1.93) 0.91 ( 0.44- 1.87) 2< S3TSut5 221 23 0.99 ( 0,48- 2.05) 0.94 ( 0.45- 1.96)1 0.86 ( 0.41- 1.82) 0.99 ( 0.48- 2.04) 0.98 { 0.48- 2.04j 0<S3TS<2 36( 24 1.52 ( 0.77- 3.00) 1.42 ( 0.71- 2.81) 1.35 ( 0.67- 2.71) 1.52 ( 0.77- 3.00) 1.51 ( 0.76- 2.99) Exc1l/ded/Trand' YJ 0 0.18 0.24 ~ 0.32 0.18 0.18 Non expasetl 21 31 1.ao 1.00 1.00 1.00 1.00 1b< 53TS 2 3 1.16 { 0.14- 9,47) 1.11 { 0.13- 9.53) i 0.58 ( 0.06- 5.58) 0.78 { 0.06-10.09) 1.00 { D.12- 8.61) 2< S37S<15 4 11 0.56 ( 0,15- 2,14) 0.55 ( 0.14- 2,14) 0.34 ( 0.08- 1.44) 0.47 ( 0.11- 2•02) 0.51 ( 0.13- 2.01) 0<S3TS<g 4 ?1 0.80 ( 0.19- 3,41) 0.76 (, 0.17- 3.44)~ 0.52 ( 0.10- 2.58) 0.79 ( 0.18- 3.39) 0.66 ( 0.15• 2.98) EXCluded/TroRd 0 0 0.51 1 0.47 0.19 0.53 0.38 Non o%pOSetl 74 103 1.00 1.00 1.00 1.00 1 15< S3T8 6 26 1.03 ( 0.34- 3,18) 1.37 ( 0.43- 4.39) 1.42 ( 0.44- 4.63) 1.37 ( 0.42- 4.43) 2< S3TS<1b 10 43 1.07 (, 0.41- 2.82) 1.39 ( 0.50- 3.90) 1.16 ( 0.40- 3.37) 1.47 (, 0.54- 4.03) 0<S3TS<.2 9 48 0.83 ( 0.31- 2.21) 1.03 ( 0.38- 2.80)~ 1.02 ( 0.37- 2.78) 0.96 ( 0.34- 2.71) ~ EXe1t/dtd/Trend f f 0.67 0.62 t 0.64 0.54 ( Non axpos®a ~ 10 95 1.00 1.00 1.00 1.00 F 15< S3TS 1 16 0.18 ( 0.02- 1.74) 0.05 ( 0.00- 0.96) 0-05 ( 0.00- 1•75) 0.13 ( 0•01- 1,51) 2< 63TS<1S 4 23 0.51 ( 0.13- 2.05) 0.40 ( 0.10- 1.68) 0.22 ( 0.03- 1.68) 0.49 ( 0.13- 1.95)I 0<S3TS<.2 ~ 3 35 0.35 ( 0.08- 1.55) 0.29 ( 0.05- 1•67)~ 0.42 ( 0.05- 3.43) 0.33 { 0.07- 1.47) 5XCluded/T/`Ind 4 0,68 ~ 0.92 0.74 ~ 0-69 ( Non expose0 3 22 1.00 j 1.00 1.00 1.00 1.00 15< S3T6 2 2 4.68 ( 0.38-57.01)' 4.14 ( 0.33-51.75) 3.22 ( 0.17-62.56) 1 3.08 { 0.21-45.84) 5.57 1 0.36-84.03) 2< $3T$<16 5 9 2.78 ( 0.45-17,18)' 2.37 ( 0.37•15.18) 1.20 ( 0.17- 8.76) 2.64 ( 0.42-16.53) 8.30 ( 0.76•90.71) D<S3TS<.2 5 16 2.49 ( 0.43-14,32)i 2.43 ( 0.39-15.22) 1.38 ( 0.17-11.44) ~ 2.33 ( 0.39-13.89) 4.29 ( 0.55-33.57) 5XCldded/TreRd 1 1 0.19 I 0.33 0.50 0.50 ) 0.18 Non a xposetl 20 17 1,00 1,00 15< S3TS 1 4 0.16 ( 0.01- 2.37) 0.19 ( 0.01• 2.73) ~ 2< S3TS<1 5 5 3 1.64 ( 0.30- 8.92) 1.47 (, 0.25- 8.57) O<rS3TS<2 23 13 1,98 2.21 ( 0.75- 6.54) i ~XC1 udtd/Trond 0 2 0•88 0.95 ~ PORTUGAL 2 Non oxpoletl 13 30 1.00 1,00 1.00 15< S3TS 4 9 1.21 ( 0.27- 5.36) 1.43 ( 0.28- 7.38) 1.00 ( 0.21- 4,88) i 2< S3TS<15 6 7 2.46 ( 0,58•10,38) 0.89 ( 0,13• 5,89) 2.57 ( 0.61-10•85) 0<S3T3<2 9 7 3.84 ( 1.07-13,85) 2.93 ( 0.74-11.62) ~ 3.93 ( 1.09-14.18} Excluded/Trend ~ ,' o 0.02 0.03 0.02 SPAIN Non expOietl 19 35 t,00 1,00 1•00 E 1.00 1.00 15< S3TS ~ 9 18 0•79 ( 0.27- 2.26) 1.02 ( 0.32- 3•25) 1-03 ( 0.32- 3.38) 0•76 ( 0.26- 2•22) 0•74 ( 0.25- 2.18) 2< S3TSe15 13 35 0.70 ( 0.28- 1,76) 0.81 ( 0.30- 2.17) 0•80 ( 0•29- 2,20) 0-70 ( 0,27- 1.77) 0.68 ( 0,27- 1.75) 0<S3TS<r2 ~ 16 51 0.52 ( 0.23- 1.21) 0.56 ( 0.23• 9,38) ~ 0.52 ( 0.20- 1.34) 0,55 ( 0.23- 1.30) 0.52 ( 0.22- 1.23) SXCIrK10d/TPQnd 1 14 20 0.52 0.63 0-61 - 0.53 0.27 32 52 1,00 1.00 1,00 ~ 1.00 15< S3T3 19 20 1.73 ( 0.78- 3.87) 1.69 ( 0.75- 3.80)( 1,77 ( 0.79- 3.97} 1.76 ( 0.78- 3.95) 2< S37$<15 9 24 0.67 ( 0.26- 1.71) 0.68 ( 0.27• 1.74) 1 0,65 ( 0.25- 1.68) 0.65 ( 0.25- 1.66) O<.S3TS<2 ~ 9 16 1.02 ( 0.39- 2.63)~ 1.02 ( 0.39- 2.64) 1,08 ( 0.42- 2.79) 1.03 ( 0.39- 2.68) ClNdad/Trend ! , 0 0.83 ! 0.84 ~ 0.78 0.87 Non oxposea e 54 1.00 1.00 1.00 1.00 1•00 15< S3TS 6 30 1,48 ( 0.45- 4•94) 1•48 ( 0.44- 5.02) 1.39 ( 0.41- 4.76) 1-67 ( 0.49- 5•68) 1.58 ( 0.47- 5•33) 2< S3TSe15 6 33 1.26 ( 0.39- 4.13) 1.23 ( 0.37• 4.10) 1.08 ( 0.31- 3.75) 0.86 ( 0.23- 3,26) 1.33 ( 0.40• 4.39) 0< S3TS<.2 6 23 1.89 { 0.56• 6.34) 1.91 ( 0.55• 6.63) 1.79 (, 0.51- 6.26) 2.30 ( 0.67• 7.91) 2.02 ( 0.59- 6.88)f, ~xcludediTreRd 0 0 0•36 ) 0.36 : 0.45 0.34 0.32 ~ (1) Model }ndurla sex, center, sex•center and age 12) Modof fncruda sox, comer, sox'canfer, age and proporiion of residential type in the last 35 yrs (REUP) (3) Model k)c)ude sex, Center, sex'conler, ape, proportion of residential type in the last 35 yrs (REUP) ard educational level (EDUC) 2063593435 (4) Model incWe sex, center, sex'canter, age and duration of exposure to list A agents (OCLAY) SS) Moda) In~a sex, oenter, sex'center, a9e and frequeney consumption of vegetables (VEGE) Risk estimates - Spouse and other cohabitants

S3UD Spouse and other cohabitants, Duration (years) (non overlapping) ALL CENTERS Total Exposed UnexOosed Exduded Min P10 01 ~ Median I Ct3 I P90 Max Mean Std Men CisCS 141 40 100 1 1.00 2.00 4.00 11.75 22.00 31.00 44.00 14.91 11.22: Co(1t70ls 531 123 405 3 1.00 2.00 6.00 13.00 20.00 35.00 44.00 15.51 11.641, All 672 163 505 4 1.00 2.00 6.00 12.00 21.00 32.00 44.00 15.37 11.50i WOrt1Ct1 UsC3 509 323 160 26 1.00 4.00 13.00 26.00 37.00 43.00 60.00 25.30 14.35; Controls 1011 664 312 35 0.50 6.00 15.00 27.00 36.00 43.00 56.00 25.70 13.01' € A6 1520 987 472 61 0.50 6.00 15.00 26.00 36.00 43.00 60.00 25.57 13.46 Atl C35CS 650 363 2ti0 27 1.00 3.00 11.00 25.00 36.00! 43.00 60.00 24.15 14.40 COtlUols 9542 787 717 38 0.50 6.00 13.00~ 25.00 34.00f 42.00 56.00 24.10 13.32 All 2192 1150 977 65 0.50 5.00 12.00~ 25.00 35.00 42.001 60.00 24.121 13.67! ALL CENTERS WITH EOUCATIONAL LEVEL AND TYPE OF RESIDENCE Men Cases 92 22 69 2.00 4.00 6.00 11.25 21.00 28.00 32.00 14.391 9.37 Controls 470 105 362 3 1.00 3.00 7.00 14.00 20.00 35.00 44.00 16.10 11.65i ~ All 582 127 431 4 1.00 3.00 7.00 14.00 21.00 33.00 44.00 15.81 11.27i WomCn C2sCS 406 257 126 23 1.00 4.001 12.00 26.00/ 37.00 44.001 60.00 25.51 14.45! Controls 868 579 2561 33 0.50 7.00 17.00 28.00 37.00 43.00f 56.00 26.47 12.88i AIl 1274 836 3821 56 0.50 7.00 15.00 27.00 37.00 43.00I 60.00 26.17~ 13.381 All Cases 498 279 195 24 1.00 4.00 11.00 25.00 36.00 43.00 60.00 24.63 14.42: Controls 1338 684 618 36 0.50 6,00 14.00 25.00 35.00 43.00! 56.00 24.88 13.23 All 1836 963 813 60 0.50 6.00 13.00 25.00 36.00 43.001 60.00 24.81 13.58 ALL CENTERS WITH DIETARY DATA Men Cases 104 31 72 i 1.00 2.00 4.00 11.50 23.00 31.00 44.00 14.47 11.67 Controls 306 84~ 242 0f! 1.00 2.00 6.00 12.00 20.00 35.00 44.00 15.16 11.88i AIl 410 95~ 314 11 1.00 2.001 6.00 `:1.50 20.00 33.00~ 44.00 14.93 11.751 Women CaSCS 405 252 131 22 1.00 3.00 11.50 25.00 36.50 44.001 60.001 24.74 14.84~ Controls 750 492 230 28' 0.50 6.00~ 15.00 26.00 ~ 36.00 43.001 56.00~ 25.44 '3.38i A11 1155 744 361 50f 0.50 5.00 14.00 6.0 36.001 43.001 60.00 25.201 13.88' All CSSCS 509 283 203 23 1.00 3.00 10.00 24.00 36.00 43.00I 60.00 23.61 14.86 Controls 1056 556 472 28 ~ 0.50 6.00 13.00 25.00 35.00 43.00 56.00 24.25 13.61-. AII 1565 839 675 51 0.50 4.00 12.00 24.00 35.00 43.00 60.00 24.04 14.04 FRANCE MCi1 Ciscs 14 2 12 0 12.00 12.001 12.00 22.00/ 32.00 32.00 32.00 22.00 14.14 Controls 23 7 16 0 4.00 4.00 6.00 6.00 I` 14.00 18.00 18.00 9.14 5.15 All 37 9 28 0 4.00 4.00 6.00 I 10.00 14.00 32.00 32.00 12.00 8.77 Won1Cn E CJSCs 63 41 22 0 1.00 2.00 6.00 17.00 32.00 46.00 55.00 20.90 16.69 { Controls 128 94 331 0.50 7.00 12.00 25.00 34.001 42.00 53.00 24.161 13.27 EIEIEI All 191 135 55 0.50 4.00 11.00 23.00 34.00) 43.00 55.00 23.17 14.41 All Cases 77 43 34 0 1.00' 2.001 6.00 17.00 32.00 46.00 55.00 20.95 16.43 Controls 151 101 49 0.50! 6.00 11.00 24.00 33.001 42.OOI 53.00 23.12 13.42 l All 228 144 83 0.501 4.00 10.00 21.50 33.00 42.00 55.00 22.48 14.36' GERMANYI MCn Cases 18 Controls 129 AU I 147 8 10 0 <^.00 2.00 3.00 10.50 19.50 23.OOI 23.00 11.38 8.45 28 101 Ol 2.00 5.00 7.50 14.00 22.50 35.00111i 38.00 16.04 10.75 36 111 01 2.00 3.00 6,50 12.50 20.00 33.00 38.00 15.00 10.36 Won1Cn CisCs 58 39 16 3 i.00 5.00 12.00 25.00 35.00 41.001 51.00 24.62 13.64 Controls 1 100 62 371 1 1.00 10.00 18.00 24.00 33.00 43.001 1 53.00 25.48 12.07 Afl fi 158 101 53 41 1.00 8.00 17.00 25.00 34.00 43.001 53.001 25.15 12.64 A1! Cases 76 47 26 3`m 1.00 3.00 10.00 23.00 35.00 41.00 51.00 22.36 13.78 Controls 229 90 138 1I 1.00 6.50 14.00 20.50 31.00~ 41.50 ~ 53.00 22.54 12.42 All 305 137 164 4 1.00 6.00 12.00 21.00 32.00N 41.00 53.00 22.48~ 12.85 CiERMANY 2 MCn Cases 29 5 24~ 0 6.00 6.00 11.50 20.00 24.00 28.00 28.00 17.901 9.03 Controls 65 8 57 0 ~ 1.00 ?.00 3.50 11.50 22.50 44.00 44.00 15.00 14.68 All 94 13 0 81 1.00 2.00 6.00 15.00 24.00 28.00 44.00 16.12 12.45 Women CaSCS 113 74 36 3 1.00 4.00 14.00 28.50 39.00 44,00 54.00 25.80 14.66 Controls 96 63 34 1 1.00 4.00 14.00 I 20.00/ 32.00 42.00 45.00 22.57 12.74 AIl 211 137 70 4 1.00 4.00 14.00 23.001 36.00 43.00 54.00 24.31 13.85 All Cases 142 79 60 3 1.00 4.00 13.00 26.00 38.00 44.00 54.00 25.30 14.46 Controls 163 71 91 1 1.00 4.00 11.00 19.00 30.00 42.00 45.00 21.72 13.08 A11 005 1 150 151 4 1.00 4.00 13.00 23.00 36.00 42.50 54.00 23.60 i3.85 MCn C35Cs € 10 0 10 0 ~ ' Controls ~ 14 2 12 0 1.00 1.00 1.00~ 10.50 20.00 20.00~ 20.00 10.50 13.44 All 24 2 22 0 1.00 1.00 1.00 10.50 20.00 20.00 20.00 10.50 13.44 Women Cases 21 9 11 1 9.00 9.00 23.00 28.00 38.00I 49.00 49.00 29.56 12.21 Controls ~ 381 19 19 0 6.00 6.00 17.00 26.00 33.00f 42.00 51.00 25.84 12.1: All 59 28 30 6.00 9.00 19.50 27.50 33.50f 42.00 51.00 27.04 12.05 A11 31 CSSCs 9 21 9.00 9.00 23.00 28.00 38.00( 49.00 49.00 29.56 12.21 E COnlrots I 52 21 31 0 1.00 6.00 17.00 26.00~ 31.001 40.00 51.001 24.38 12.76 AN t 83 30 52 1.00 7.50 19.00 26.50 33.001 42.00 51.00 25.93 12.6t MCn Cases 8 3 5 0 5.00 5.00 5.00 10.00 21.001 21.001 21.00 12.00( - 8.19 ~ Controls 103 31 71 1 00 2.00 7.00 14.00 20.00 29.00 ~ 39.00 ~ 14.52 10.32 AU 111 34 76 1 '.00 2.00 7.00 13.00 20.00 29.00 39.00~ 1 14,29 10.07 Women Cases 32 22 9 11 1.00 10.00 19.00 28.00 33.00 42.00 45.00 26.23 11.92 Controls 118 86 32 0 2.00 8.00 19.00 29.00 36.00 43.00 48,00 27.33 12.05 All 150 108 41 1 1.00 8.00 19.00 29.00 36.00 43.00 48.00 27.10 11.9E All CAs®s 40 25 14 1 1.00 10.00 15.00 25.00 31.00 42.00 45.00 24.52 12.34 Controls 221 117 103 1 1.00 6.00 14.00 24.00 34.00! 41.00 48.00 23.93 12.85 All 261 142 117 2 1.00 6.00 14.00 25.00 34.00 41.00 48.00 24.04 12.7c -C,-'06359 .~439 Descdotive siatisfics S44use and_other cohabitants

S3AV Spouse and other cohabitants, Average exposure (cigarettes/day) ALL CENTERS Total I Exposed Unexoosed Excluded Min P10 01 ` Median ~ Q3 P90 L Max ~ Mean I Std M0r1 Cases 138 32 96 8 0.10 0.73 1.43 3.21 5.14 '.50 14.06` 3.95 3.3( Controls 517 92 394 31 0.10 1.00q {{ 2.13 4.09 7.34 11.43 25.71i 5.41 4.& All 672 124 492 56 0.10 1.00 ! 1.79 3.811 6.88 10.71 25.715.03 4.5t WOn10n C7SCf 486 242 154 90 0.05 1.50 2.86 5.76 10.71 21.21 61.69 8.991 9.7' Controls 885 484 269 132 0.05 1.50 1 3.00' 5.62 11.08 18.11 60.00 8.101 7.61 AII 1520 726 423 371 0.05 1.50 3.001, 5.71 10.93 19.00 61.69 8.40 8.4: All aSCf 650 274 252 124 0.05 1.39 2.59 5.15 10.02 20.00 61.69! 8.40 9.3t Controls 1542 576 663 303 0.05 1.18 ~ 3.00 5.241 10.21 17.14 60.001 7.67 7.3f AII 2192 850 915 427 0.05 1.29 2.86 5.15 10.02 18.29 61.691 7.91 8.0E ALL CENTERS WITH EDUCATIONAL LEVEL AND TYPE OF RESIDENCE Mcn Cases 69 14 67 8 0.73 1.47 3.00 4.07 6.75 7.50 10.31 4.55 2.6< Controls 456 77 351 28 0.10~ 1.00 2.25 3.86 7.50 12.86 25.71~ 5.53 5.1' All 582 91 418 53 0.10f 1.00 2.25 3.86 7.18 11.43 25.71 5.38 4.8-' WOfncrt C'.S3Cf 383 184 120 79 0.10 1.65 1.84 5.15 10.01 21.881 61.69 8.88 - 10.2' COf1U0lf 742 405 213 124 0.10 1.56 3.43 5.83 11.60 18.57 60.00 8.53 7.8' AA 1274 589 333 352 0.10 1.55 3.07 5.71 11.25 19.14 61.69 8.641 8.0';. Atl C32Cf 488 198 187 113 0.10 1.50 2.86 5.07 10.00 20.42 61.69 8.58 9.92 Controls 1338 482 564 292 0.10 1.50 3.00 5.56 10.97 17.96I 60.00 8.051 7.5% All 1838 680 751 405 0.10 1.50 3.001 5.33 10.68 18.57 61.69 8.20 8.2F ALL CENTERS WITH DIETARY DATA Men CBscs 101 24 70 7 0.10 0.10 1.52 3.21 5.05 7.50 14.06 3.90 3.3E Controls 292 39 231 22 0.10 0.89 1.18 ~ 4.29 7.18 11.43 20.00 4.964.5, AH 410 63 301 46 0.10 0.73 1.29 3.75/ 6.43 10.00 20.00 4.56 4.1, Women C95CS 382 182 125 75 0.05 1.50 2.80 5.68 10.00 20.00/ 53.31 8.55 9.1E COnlr0ls 624 338 187 99 0.05 1.18 3.00 5.71 11.79 18.57 60.00 8.27 7.T All 1155 520 312 323 0.05 1.49 3.00 5.71 11.25 18.93 60.00 8.37 8.2: Afi C85ef 509 206 195 108 0.05 1.47 2.50 5.00 9.291 19.49 53.31~ 8.01 8.8: COntrD{f 1058 377 418 261 0.05 1.00 3.00 5.50 11.25 17.961 60.00 7.93 7.5£ All 1565 583 613 369 0.05 1.18 2.69 5.16 10.61 18.34 60.00~ 7.96 8.0C FRANCE MOn Cases 14 2 12 0 0.73 0.73 0.73 1.47 2.22 2.22 2.22 1.47 1.0: Controls 23 5 16 2 0.23 0.23 2.25 2.46 1 5.001 20.00 20.00 5.99 8.0' All 37 7 28 2 0.23 0.23 0.73 2.25 5.00 20.00 20.00 4.701 6.9, WOrtkn CpfOs 63 36 22 5 0.20 1.29 3.00 5.32 10.331 23.69 50.00 9.76 11.5" 1 Controls 128 85 33 10 0.10 ..50 3.34 6.23 15.00 18.57 31.43 8.931 7.1E A11 191 121 55 15 0.10 1.50 3.01 5.86 12.86 19.00 50.00 9.18 8.6c Tl C9s@f 77 38 34 0 0.20 1.13 2.57 5.00 10.16 23.69 50.00 9.33 11.3° ~ Controls 151I 9011 49 ?2 0.10 1.49 3.00 5.80 15.00 98.79 31.43 8.771 7.21 I All 228f 128 83 '.7 0.10 1.29 3.00 5.32 12.86 19.05 50.00 8.931 8.61 GERMANY1 Men Cases COntrOf All 18 4 10 4 3.00 3.00 3.91 5.05 6.021 6.75 6.75 4.96 1.5E 129 14 101 14 0.10~ 1.00 2.25 5.25 7.89 13.39 15.00 5.931 4.5: 147 ?8 111 18 0.10 1.00 3.00 5.05 7.76 13.39 15.00 5.721 4.01 Women Cases $8 24 16 16 1:.18 1.55 2.74 5.07 13.58 20.421 53.31 9.85 11.8C Controls 100 ~ 47 37 16f 0.75 2.25 4.18 5.75 11.25 17.14 30.53 8.53 6.9' A11 158 71 53 341 0.75 1.931 3.21 5.58 11.441 17.14~ 53.31 8.981 "0.8' All Cases ~®76 28 26 22 1.18 7.55 2.90 5.05 12.47 20.42 53.31 9.16 11.0< COrltrOl4 ~ 229 61 138 30 0.10 1.93 3.75! 5.75 10.92 15.161 30.53 7.931 6.5( All 305 89 164 52 0.10 1.55 3.13 5.36 10.931 16.71 53.31 8.321 8.1E GERMANY2 Men Cases 29 3 24 2 1.47 1.471 i.47 7.50 10.31 10.31 10.31 6.43 4.52 Controls 55 4 07 2.25 4 2.251 3.00 4.13 5.25~ 6.00 6.00 4.13 1.5e ~ All 94 7 81 1 6 :.47 ,.47 2.25 4.50 7.50 10.31 10.31 5.11 3.05 WOfien C95QS 113 53 36 241 0.10 1.50 2.50 5.15 7.66 15.78 38.93 7.71 8.15 COnlrOlf 98 51 34 13 0.60 1.50 3.00 4.50 12.75 19.77 60.00 9.01 10.2E A1) 211 104 70 37 0.10 1.50 3.00 5.02 10.39 19.77 60.00 8.35 9.2- All Cases CCntrOlS All 142 163 305 S6 55 111 60 91 151 26 0.10 17 0.60 43 0.10 1.50 1.50 ?.50 2.50 3.00 3.00 5.15 4.50 4.89 8.27 15.78 38.93 12.75 19.771 60.00 10.02 16.43 60.00 7.641 8.66 8.14~ 8.0~ 9.9t 9.01 GERMANY3 Men CasCS 10 0 10 0 Controls 14 2 12 0 1.00 1.00 1.00 1.00 1e00~ 1.00 1.00 9.00 O.Oc All 24 2 22 0 1.00 1.00 1.00 1.00 1 00 1.00 1.00 1.00 0.0( Women Cases ~ 21 7 i1 3 1.50 50 50 2.25 6.00 6.75 6.75 3.71 2.(3: COnU015 38 14 19 5 0.30 0.50! 1.50 1.98 3.83 7.50 15.00 3.46 3.8: All ~ 59 21 30 8 0.30 0.751 1.50 2.25 4.50 6.75 15.00 3.54 3.3E All Cases 31 7 21 3 1.50 1.50' 1.50 2.25 6.00 6.75 6.75 3.71 2.3: COnIr01f 52 16 31 5 0.30 0.50 1.00 1.64I! 3.79 7.50 15.00 3.15 3.6F All 83 23 52 8 0.30 0.75 1.50I 2.251 4.50 6.75 15.00 3.32 3.2s ITALY I `I:Zn CaSCS 8 2 5 1 4.71 4.71 4.71 5.86 7.00 7.00 7.00 5.86 1.62 ~ Controls 103] 27 711 5 0.81 1.00 2.00 4.18 8.46 13.56 25.71 6.31 5.9: AIt 1111 29 761 6 0.81 1.00 2.29 4.71 8.25 13.56 25.71 6.28 5.7: ':YOm6r1 CasCS 32 18 9 5 1.60 9.95 3.07 4.64 10.00 26.43 61.69 9.70 14.2' COnlfOlf 118 69 32 17 0.50 2.61 3.86 5.75 11.16 20.60 53.23 8.97 8.7• All 150 87 41 22 0.50 2.571 3.71 5.59 10.71 20.60 61.69 9.12 10.0• Atl Cases 40 20 14 6 1.60 2.26 3.26 4.71 9.83 19.71 61.69 9.311 13.5: COntrO(S 221 96 103 22 0.50 2.26 3.24 5.69 9.92 17.83 53.23 8.22; 8.1 All 2611 116 117 28 0.50 2.26 3.24 5.44 9.92 17.83 61.69 8.41 9.2' ~'063593A•47

S3TS Spouse and other cohabitants, rime since last exposure (years) ALL CENTERS ~ Total Exposed UnexpOSed Exduded Min P10 01 Median { 03 1 P90 f Max ~ Mean ~ Std MCn CaSCf 141 40 100 1 0.00 0.00 0.00 0.50 14.00 34.00 44.00 8.75 13.5:. Contrpla 531 123 405 3 0.00 0.00 0.00 ~ 2.00 13.00 26.00 43.00 8.01 10.7, All 672 163 505 4 0.00 0.00 0.00 2.00 13.00 27.00 44.00 8.19 11.4_ WOmetl C83C3 509 327 160 22 0.00 0.00 0.00 7.00 18.00 28.00 52.00 10.69 71.65 Ccrttrolz 1011 674 312 25 0.00 0.00 0.00 7.00 17.00 26.00 50.00 10.02 10.7E AA 1520 1001 472 47 0.00 0.00 0.00 7.00 17.00 27.00 52.00 10.23 11.ir A~ CSSE3 650 387 280 23 0.00 0.00 0.00 7.00 17.00 29.00 52.00 10.47 12.0; CanttCl3 1542 797 717 28 0.00 ~ 0.00 0.00 6.00 16.00 26.00 50.00 9.71 10.7c All 2192 1164 977 51 0.00 0.00 0.001 6.00 17.00 27.00 52.00 9.95 11.2C ALL CENTERS WiTH EDUCATIONAL LEVEL AND TYPE OF RESIDENCE MCt1 CSSCS 92 22 69 1 0.00 0.00 0.00 0.00 10.00 22.00 44.00 6.86 1 11.8: Ca17o18 470 105 362 3 0.00 0.00 0.00 2.00 13.00~ 26.00 43.00 7.79 10.61 AA 582 127 431 4 0.00 0.00 0.00 1.00 13.00 26.00 44.00 7.63 10.8• IWOf11Ct1 CdSC9 406 260 126 20 0,00 0.00 0.00 7.50 17.00 27.50 52.00 10.81 11.6t i ConWla 868 589 256 23 0.00 0.00 0.00 7.00I 16.00 25.00 50.00f 9.77 10.6, AU 1274 649 382 43 0.00 0.00 0.00 7.00 17.00 26.00 52.00i 10.09 10.9' Al/ Cases 498 282 195 21 0.00 0.00 0.00 7.00 17.00 2-7.00 52.00 10.50 11.71 Controls 1338 694 618 26 0.00 0.00 0.001 5.50~ 16.00 25.00 50.00~ 9.47 10.6 All 1836 976 813 47 0.00 0.00 0.00 6.00 16.00 26.00 52.00 9.77 10.9 ALL CENTERS WITH DIETARY DATA MGn C95e9 Controls All 104 306 410 31 64 95 72 242 314 1 0 1 0.00 0.00 0.00 0.00 0.00 0.001 1 0.00 0.00 0.00 0.00 5.00 3.00 19.00 19.50 19.00 37.00 44.00 29.00 43.00 30.00 44,00 10.321_ 10.25 10.27 14.8 12.3: 13.1 Women C3SC5 405 255 131 19 0.00 0.00 0.00 8.00 19.00 30.00 52.00 11.61 12.1r COntfDlf 750 499 230 21 0.00 0.00 0.00 7.00 17.00 26.00~ 50.00 10.09 10.6' All 1155 754 361 40 0.00 0.00 ~ 0.00 8.00 17.001 27.00 52.00 10.61 11.2: ~A11 CLSCS 509 286 203 20 0.00 0.00 0.00 8.00 19.00 30.00 52.00 11.47 12.a Controls 1056 563 472 21 0.00 0.00 0.00 7.00 17.00 26.00 50.00 10.11 10.8, A11 1565 849 6751 41 0.00 0.00 0.00 7.00 18.00 27.00 52.00 10.57 i1.4. FRANCE MCt1 C35eS 14 2 12 0 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.001 0.0 COnU03 23 71 16 0 0.00 0.00 0.00 19.00 27.00 29.00 29.00 15.711 12.6 All 37 9 28 0 0.00 0.00 0.00 9.00 26.00 29.001 29.00 12.22 12.9. WOR1Cl1 Cases ~ 83 41 22 0 0.00 0.00 1.00 7.00 19.00 24.00 47.00 11.15 11.7 E Controls ~ 128 95 33 0 1 0.00 0.00 0.00 6.00 17.00 20.00 42.00 8.37 9.1 Al) 191 136 55 0 0.00 0.00 0.00 6.50 17.00 21.001 47.00 9.21 10.0 All C3SCf 7 43 34 0 0.00 0.00 0.00 7.00 19.00 24.00 47.00 10.63 11.0 ~ n8~ C , ~ ( f/ A '28 145 83 0 0,00 0.00 0.00 7.00 ?8.00 23.00 47.00 9.39 10 ? GERMANY 1 MCt1 C95Cf 18 8 10 0 0.00 0.00 0.00 0.00III 16.00 31.00 31.00 7.88 12.: Controls 129 L 28 101 0 0.00 0.00 0.00 6.00~ 16.50 30.00 43.00 10.43 12.4 F All 147 36 111 0! 0.00 0.00 0.00 5.00 16.50 30.00 43.00 9.86 12 : WORiCt1 CoSCf 58 39 16 3 0.001 0.00 4.00 11.00 18.00 26.00 36.00 11.74 5 C COnlrolS 100 63 37 0 0.00 0.00 2.00 13.00 20.00 24.00 46.00 11.97 10.0 All 158 102 53 3 0.00 0.00 3.00 12.00 18.00 24.001 46.00 11.88 9 E AI1 CiSC3 76 47 26 3 0.00 0.00 1.00 10.00 18.00 26.00 36.00 11.09 e.t C0t11r01f 229 91 138 0 0.00 0.00 0.00 11.00 20.00 25.00 ~ 46.00 11.49 10 8 All 305 738 164 3 0.00 0.00 0.00 10.50 18.00 25.00 ! 46.00 51.36 10.3 GERMANY2 Mtn CASCf 29 5 24 0 0.00 0.00 1.00 9.00 13.00 44.00 44.00 13.40 17.9 COntrO;E ~ 65 8 57 0 0.00 0.00 0.00 1.50 21.50 41.00 41.00 10.88 15.6 All 94 13 81 0 0.00 0.00 0.00 3.00 15.00 41.00 44.00 11.85 15.9 WCtriCn C35C5 113 76 36 1 0.00 . 0.00 0.00 5.00 17.00 28.00 41.00 10.20 11.5 Controls 98 64 34 9! 0.00 0.001 0.00~ 11.50 20.00 27.00 50.00 12.14 11.4 All 211 140 70 1 0.00 0.00 0.00 8.50 18.00 27.50 50.00 11.09 11.7 A11 C3;CS 142 81 60 1I 0.00 0.00 0.00 5.00 17.00 28.00~ 44.00 10.40I€ 12.- COntrGS 163 72 91 0 0.00 ~ 0.00 0.00 10.00 20.00 28.00'! 50.00 12.OOI 11.E ' All 305 153 151 1 0.00 0.00 0.00 8.00 18.00 28.001 50.00 11.15 12.C 10 0 10 0 ~ i II ff 14 2 12 0 3.001 3.00 3.00~ 6.50 10.00~ 10.00 10.001 6 50I "= 24 2 22 0 3.00 3.00 3.00 i 6.50 10.00 . 10.00 to,p0i 6 50 4.~ 21 10 11 0 0.00 0.001 0.00 5.00 13.00 26.00 34.00 8.60 10.5 38 19 19 0 0.00 0.00 0.00 5.00 12.00 27.00 41.00 8.16 11.7 59 29 30 0~ 0.00 0.00 0.00 I 5.00 12.00 27.00 41.00~ 8.31 10.5 A11 CiSCS 31 ',0 21 01 0.00 0.00 0.00 5.00 13.00 26.00 34.00 8.60 10.9 Controls 52 21 31~ 0.00 0.00 0.001 5.00 0 10.00 23.00 41.00 8.00 10.E ~` All 63 31 52/ ~ 0 0.00 0.00 0.00 5.00 12.00 23.00 41.00 8.19 10.E ITALY 1 MCn C35Cf 8 3 5 0 0.00 0.00 0.00 3.00 15.00I 15.00 15.00 6.00 7.E Controls 103 31 71 if 0.00 0.00 0.00 1.00 13.00! 17.00 29.00 6.42 8.7 All t11 34 76 0.00 0.00 0.00 2.00 13.OOf 17.00 29.00 6.38 6.E WOR1Ct1 C'JSCS 32 22 9 1 0.00 0.00 0.00 8.50 17.00 23.00 32.00 10.18 10.' Controls 118 86 32 0 0.00~ 0.00 0.00 7.00 15.00 24.00 43.00 9.69 10.£ All 150 108 41 1 0.00 0.00 0.00 7.00 15.50 24.00 43.00 9.79 10.E All C33CS 40 25 14 0.00 0.00 0.00 7.00 15.001 23.00 32.00 9.68 9.E Controls 221 117 103 0.00 0.00 0.00 5.00 15.001 23.00 43.00~ 8.82 10.: All 261 142 117 2 0.00 0.00 0.00 5.50 15.00 23.00 43.00 8.97 10.: 1-2:063593451

2eill lulehicles Risk estimates

'53UD Spouse and other cohabitants, Duration (years) (non ovedapping) NlSTOLOGICALLY CONf1RMED DIAGNOSIS Tola1 Exposcd Urexposed Exduded Min P10 ; 01 Median ~ 03 P90 { Max ( Mean Std ~ MCn CSSCS 152 40 111 1 5.00 2.00 4.00 11.75 22.00 31.00 44.00 14.91 11.22 COnlrol3 580 124 452 1 4 1.00 2.00 6.00 12.50 20.00 35.00 44.00 15.43 11.63 AN 732 164 563 5 1.00 2.00 6.00 12.00 20.50 32.00 44.00 15.30 11.50 WCrtICl~ CSSC9 531 326 t79 26 1.00 4.00 13.00 25.00 36.00 43.00 60.00 25.05 14.16 CGOt7olf 1078 684 355 37 0.50 6.00 15.50 27.00 36.00 43.00 56.00 25.76 13.05 All 1607 1010 534 63 0.50 6.00 15.00 26.00- 36.00 43.00 60.00 25.53 13.41 a/ C93C3 603 366 290 27 1.00 4.00 11.00 24.00 35.00 43.00 60.00 23.94 14.21 CCntlOf3 1656 808 807 41 0.50 6.00 13.00 25.00 34.50 42.00 56.00 24.17 13.36 a1 2339 1174 1097 68 0.50 5.00 12.00 24.00 35.00 42.00 60.00 24.10 13.63 SOUAhtOUS CELL CARCINOMA Men CssC3 28 CCntrod3 580 4 24 0 4.00 4.00 7.00 15.50 25.50 30.00 30.00 16.25 11.56 124 452 4 1.00~ 2.00 6.00 12.50 20.00~ 35.00 44.00 15.43 11.63 All 808 128 476 4 1.00 2.00 6.00 12.50 20.50 35.00 44.00 15.45 t1.58 WOrt1Cn Gf5C8 97 62 31 4 1.00I 2.00 11.00 25.00 37.00 42.00 54.00 24.06 14.78 Controls 1076 684 355 37 0.50~ 6.00 15.50 27.00 36.00 43.00~ 56.00~ 25.76 13.05 al 1173 746 3861 41 1 0.50 6.00 15.00 26.50 36.00 43.00 56.00 25.62 13.20 All C91Cf 125 66 55 4 9.00 2.00 11.00 24.00 37.00 42.00 54.00 23.59 14.65 CGnt101i 1658 808 807 41 0.50 6.00 13.00 25.00 34.50 42.00 56.00 24.17 ~ 13.36 Atl '781 874 862 45 0.50 5.00 13.OOJ _ 25.00 35.001 42.00 56.00 24.13 13.46 SMALL CELL CARCINOMA MCn CaSCS 14 2 12 0 23.00 23.00 23.00 27.00 31.00 31.00 31.00 27.00 5.66 COnlroif 580 124 452 4 1.00 2.00 6.00 12.50 20.00 35.00 44.00 15.43 1 11.63 Aq 594 126 464 4 1.00 2.00 6.00 13.50 22.00 35.00 44.00 15.61 11.64 WomM1 C7:CS 67 39 25 3 2.00 5.00 18.00 27.00 41.00 44.00 51.00 26.92 13.54 Controls 1076 684 355 37 0.50 6.00 `5.50 27.00 36.00 43.00 56.00 25.76 13.05 al 1143 723 380 40 0.50 6.00 16.001 27.00 36.00 43.00` 56.00 25.82 13.07 al CBSCf 81 41 37 3 2.00 6.00 19.00 27.00 39.00 43.00 51.00 26.93 13.23 Controls 1656 808 807 41 0.50 6.00 93.00 25.00 34.50 42.001 56.00 24.17 13.36 All 1737 849 844 441 0.50 6.00 13.00 25.00 35.00 42.00 56.00 24.31 13.36 ADENOCARCINOMA Men Casas 80 1 23 1 66 1 1.00 2.00 4.00 12.00 20.00 31.00 44.00 13.93~ 11.37 Controls 600 i 124 452 41 1.00 2.00 ` 6.00 12.50 20.00 35.00 44.00 15.43 11.63 All 860 147 508 51 1.00 2.00 6.00 12 00 20.00 34.00 44.00 15.19 11.56 WCmon Cas~f 281 173 95 13 1.00 5.00 13.00 25.00 36.00 45.00 55.00 25.00 14.30 , 1076 Controls 684) 355 37 0.50 6.00 15.50 27.00 36.00- 43.001 56.00 25.76 13.05 ~ E Aq 1357` 857 450 50 0.50 6.00 15.00 26.00 36.00 43.00 56.00 25.61 13.30 al CfSCS ' 361 196 151 14 1.00 4.00 11.00 23.50 34.50 44.00 55.00 23.70 14.41 ~ COntrolO ~ 1656 808 807 41 0.50 6.00 13.00 25.00 34.50 42.00 56.00 24.17 13.36 ~ AH 2017 1004 958 55 0.50 5.00 12.00 24.00 34.50 43.00 56.00 24.08 13.57 MCn CesCS 30 11 19 0 2.00 4.00 4.00 10.00 28.00 31.00 32.00 14.27! 11.45 Controls S80 124 452 4 1.00 2.00 6.00 12.50 20.00~ 35.00 44.00 15.43 11.63 A4 610 135 471 4~ 1.00 2.00 6.00 12.00 20.00 33.00 44.00 15.33 11.57 IWCO1St1 CifCS 86 52 28 6 1.00 4.00 15.00 25.00 35.00 40.00 60.00 24.96 13.63 COntr0lf 1076 684 355 37 0.50 6.00 15.50 27.00 36.00 43.00 56.00 25.76 13.05 AU 1162 736 383 43 0.50 6.00 15.00 26.00 36.00 43.00 60.00 25.70 13.08 al Cases 118 63 47 6 1.00 4.00 10.00 22.00 34.00 40.00 60.00 23.10 13.81 ~ CIN11r01S 1856 808 807 41 0.50 6.00 13.00 25.001 34.50 42.00 56.00 24.17 13.36 AN 1772 871 854 47 0.50 6.00 13.00 25.00 34.00 42.00 60.00 24.091 13.39 >75'i .. OF LIFESPAN IN RURAL AREA OR INTERMEDIATE CITIES MCn CaSCS 76 10 66 Canlras 226 All 301 38 48 185 251 0 21 21 1 .00 1.00 1.00 2.50 2.00 2.00 6.00 5.00 5.00 15.00 31.00 10.00 19.00 10.00 23.50 33.00 40.00 40.00 34.00 16.80 43.00 14.76 43.00 15.19 12.13 13.27 12.94 Nlomcn Ca,es E 237 149 83 5 1.00 5.00 14.00 26.00 38.00 43.00 55.00 25.56 13.87 Controls 462 ' 202~ 172 8 0.50 6.00 14.00 25.00 34.00 42.00 51.00~ 24.40 12.78~ AN 698) 431 255 13 0.50 6.00 14.00 25.00 35.00 42.00 55.00~ 24.80 13.161 A!1 Cases 313 158 14 5 1.00 5.00 74.00 25.00 36.00 43.00 55.00 25.01 13.90 687 Controls 320 357 10 0.50 5.00 12.00 23.00! 33.501 42.00 51.00 23.25 13.19 Atl 1000 479 5061 15 0.50 5.00 12.00 24.001 35.00 42.00 55.00 23.84 13.44 >75'f. OF UFESPAN IN URBAN AREA Mcn CBSCS 48 21 26 1 1.00 2.00 4.00 11.00 21.00 28.00 44.00 14.21I 11.38 CCMrU3 257 62 193 2 1.00 4.00 7.00 13.50 20.00 30.00 44.00 15.56 11.02 al 3051 83 219 3 1.00 3.00 7.00 12.00 21.00 30.00 44.00 15.22 11.06 WOmCn CisC3 ~ 198 122 60 14 1.00 3.001 13.00 28.00 36.00 45.00 60.00 25.73 54.72 Controls ' 454 315 120 19 1.00 7.00i 18.00 29.00 38.00 44.00 56.00 27.59 13.20 I AN 1 650 437 180 33 1.00 '.00 17.00 29.00 37.00 45.00~ 60.00 27.07 13.65 al Ci6Cf $44 143 86 15 1.00 3.00E 11.00 25.00 35.00 44.00 60.00I 24.04 14.82 ~ Con1rolS 711 377 313 21 1.00 6.001 15.00 27.00 36.00 43.00 56.00f 25.61 13.61 AN 955 520 399 36 1.00 6.00 13.00 26.00 36.00 44.00 i 60.00 . 25.18 13.96 2. 0 6i.':)i5 9 3 "tYG

S3CU Spouse and other cohabitants, Cumulative exposure (packs/day x years) t6STOZOGICALLY CONFIRMEO DIAGNOSIS E Total Exoosed Unexposed Excluded I Min P10 01 Median ~ Q3 { P90 ~ Max f Mean Std ~ Men C33€S 149 32 109 8 0.01 0.13 0.32 1.78 5.84 9.79 23.91 3.83 5.10 CGVttrd9 866 93 ~ 441 32 0.03 0.36 0.90 2.00 5.12 12.65 23.29 4.16 5.18 Atl 732 125 550 57 0.01 0.26 0.70 1.93 5.12 12.38 23.91 4.07 5.14 WOr= CiSCS 513 250 174 89 0.01 0.48 1.77 6.64 14.79 31.87 138.80 12.23 17.17 Controls 950 504 312 134 0.01 0.68 2.55 6.89 14.21 27.36 69.19 11.05 12.71 NI 1607 754 486 367 0.01 0.55 2.29 6.85 14.40 28.44 138.80 11.44 14.34 AH C33Et 683 282 283 118 0.01 0.38 1.40 5.83 13.68 28.43 138.80 11.27 16.47 Controls 1656 597 753 306 0.01 0.51 F 1.93 6.00 ~ 12.66 25.11 P 69.19 I 9.98 12.11 Ab 2339 879 1036 424 0.01 0.46 1.82 5.86 13.00 26.60 138.80 10.39 13.67 SQUAMOUS CELL CARCINOMA MOr1 CaSCi 28 4 24 0 0.28 0.28 0.64 2.981 '.23 7.50 7.50 3.43 3.40 ContrOlS 566 93 441 32 0.03 0.36 ~ 0.90 2.00 5.12 12.65 23.29 4.16 5.18 All 606 97 465 46 0.03 0.32 0.90 2.00 5.12 12.65 23.29 4.13 5.11~ WOrruXt Ca3t3 91 46 30 75 0.03 0.38 1.21 8.05 16.00 24.64 68.00 11.54 14.24 Controls 950 504 312 134 0.01 0.68 2.55 6.89 14.21 27.36 69.19 11.05 12.71 AN 1173 550 342 281 0.01 0.62 2.40 6.92 14.25 27.20 69.19 11.09 12.83 AA c95tf Controls A5 125 1656 1761 50 597 647 54 753 807 21 306 327 0.03 0.01 0.01 0.37 0.51 0.51 1.19, 6.82 14.00 1.931 6.00 12.65 1.88 6.00 12.86 24.32 25.11 25.07 68.00 69.19 69.19 10.89 9.98 10.05 13.85 12.11 12.25 SMALL CELL CARCINOMA Men Cases 13 2 11 0 4.65 4.65 4.65 6.21 7.76 7.76 7.76 6.21 2.20 Controls 566 93 441 32 0.03 0.36 0.90 2.00 5.121 12.65 23.29 4.16 5.18 AH 594 95 452 47 0.03 0.36 0.90 2.00 5.14'2.65 23.29 4.20 5.141 WOfiCn CASCS 62 28 23 11 0.15 0.44 1.45 3.13 14.21 22.50 67.33 9.44 13.86 Control3 950 504 3121 134 0.01 0.68) 2.55 6.89 14.21 27.36 69.19 11.05 12.71 All 1143 532 335 276 0.01 0.65 2.40 6.76 14.21 27.05 69.19 10.96 12.76 All CasCt 81 30 3417 0.15 0.45 1.65 3.67 12.70 21.02 67.33 9.23 13.40 Controls 1656 597 753I 306 0.01 0.51 1.93 6.00 12.65 25.11~ 69.19~ 9.98 12.11 AN 1737 627 ?87i 323 0.01 0.51 1.91 5.79 12.70 25.07 69.19 9.94 12.17 ADENOCARCINOMA MCn C35lS 79 17 56 6 0.01 0.02 0.20 0.84 6.74 12.38 23.91 4.211 6.44 Conlr0lt 556 93 4411 32 0.03 0.36 0.90 2.00 5.12 12.65~ 23.29 4.16 5.18 All 660 110 497 53 0.01, 0.24 0.61 1.91~ 5.14 12.51 23.91 4.16 5.36 WOnSen CaSCS 277 140 95 42 0.01~ 0.50 1.74 6.64~ 15.68 35.78 138.80 13.20! 18.77 COntr0lf 950 504 312 134 0.01 0.68 2.55 6.89 14.21 27.36 69.19 11.05I 12.71 AII 1357 644 407 306 0.01 0.65 2.34 6.85 14.43 30.00 138.80 11.52 14.26 ,r9l1 C3s05 361 157 151 53 0.01 0.35 1.40 6.00 14.20 34.50 138.80 12.23 18.06 Controls 1658 697 753 306 0.01 0.51 1.93 '0.00 12.65I 25.11 69.19 9.98 12.11 All 2017 754, 904 359 0.01 0.48 1.86 6.00 13.03 27.03 138.80. 10.44 13.58 MCn Cases 29 9 18 2 0,30 0.30 0.96 1.67 3.50 10.50 10.501 2.77 3.13 COntrO1D 566 93~ 441 32 0.03 0.36 0.90) 2.00 5.12 12.65 23.29 4.16 5.18 All 610 102 459 49 0.03 0.36 0.90 1.96 4.60 12.38 23.29 4.03 5.04 WOmCn CesCS I 83 36 26 21 0.01 0.53 2.64 7.53 13.261 24.56 93.29 11.481 16.64 Controls I 950 504 312 134 0.01 0.68 2.55 6.89 14.21i ~ I 27.36 69.19 ~ 11.051 12.71 ` All 1162 540 338 ~ 284 0.01 0.68 2.55 6.95 14.08 27.20 93.29 11.08 12.99 AN Cmsl4 116 45 44 27 0.01 0.53 1.77 6.41 10.50 22.50 93.29 9.74 15.31 Controls 1656 597 753 306 0.01 0.51 1.93 6.00 12.65 25.11 69.19 9.98 12.11 Ak 1772 fi42 797 333 0.01 0.53 1.91 6.00 12.60 24.56 93.29 9.96 12.35 ;-7S!4 OF LIFESPAN IN RURAL AREA OR INTERMEDIATE CITIES MCn Cases 73 64 2 0.07 0.07 0.32 2.40 6.74 23.91' 23.91 5.42 8.47 Contrclb 212 22 '751 15 0.03 0.25 0.61 1.35 2.81 10.29 1 21.43 3.11 5.18 All 301 29 239 33 0.03 0.07 0.61 1.45 3.15 12.86 23.91 3.67 6.05 WOmCn C4sC3 220 108 78 34 0.01 0.46 1.39 6.51 14.36 32.86/ 76.03 11.96 16.43 Controls 361 184 137 40 0.01 0.51 2.00 6.28 !) 64.00 13.18! 22.93 9.72 10.80 AU 699 2921 215 192 0.01 0.51 ':.86 6.41 I 1 14.001 25.71 76.03 10.55 13.18 All CiSG3 313 11®5 142 55 0.01 0.44 1.30 6.21 14.00 28.43 76.03 11.56 16.11 Controls 687. 206 312 169 0.01 0.48 1.66 f 5.53 12.30 22.50 64.00 9.01 10.53 All 1000 321 454 22S 0.01 0.47 1.50 ) 5.75 12.94 23.91 76.03 9.93 12.85 a755C OF LIFESPAN IN URBAN AREA Men Cases 45 17 26 5 0.01 0.02 0.30 2.84 4.95 10.50 12.38 3.73 4.06 Conlr014 257 53 193 11 0.07 0.36 0.831 2.29 7.37 12.65~ 19.29 4.50~ 5.04~ All 305 70 219 16 0.01 0.21 0.691 2.391 7.37 12.38 19.29 4.31~ 4.81 WorrtEn C~ses 193 97 60 36 0.01 0.53 2.53 6.00 15.71 34.11 138.80 13.26 20.02 ~ COr1trG5 435 245 715 75 0.02 0.90 3.21 7.82 15.00 30.53 69.19 12.31 13.98 All 850 342 1751 133 0.01 0.90 2.84 7.18 15.07 30.74 138.80 12.58 15.90 A1 C3584 244 114 861 44 0.01 0.38 2.29 5.31 12.38 30.88 138.80I 11.84J 18.83 COr11r015 711 298 308 105 0.02 0.65 2.14 6.79 13.50 27.64 . 69.19ttti 10.92 13.19 AI1 955 412 394I 149 0.01 0.54 2.17 6.51 13.32 29.25 138.80 11.18 14.95 2063593446

D S3CU Spouse and other cohabitants, Cumulative exposure (packsjday x years) 41.€tt OKI.`f Lwel of axaosura ~ Cues I Conttota NE., :i3CU<13 13<S3CU<•25 fxoluded/Trend WOMEN ONLY NE., 53CU<r13 13<S3CU<25 25<S3CU OR{1 95% CI ( O 2) 95% CI OR(3) 95% CI ( OR(4 95X CI ( OR(5 95% CI ( 1.00 , 1.00 1•00 1.00 1 1.00 1.02 ( 0.11. 9.22)~ 1.30 ( 0.13-12.81)~ 0•00 ( 0.00-99.99)1 1.04 ( 0.12- 9.36)/ 2.44 ( 0.18-32.93) 0.98 0.96 0.97 0.98 318 619 1.00 1.00 1.00 E 1.00 1.00 40 76 1.03 ( 0.68- 1.58) 0.91 ( 0.57- 1.46) ~ 0.63 ( 0.36- 1.11) 1.08 ( 0•71• 1.66) 0.89 ( 0.54. 1.46) 38 58 1.40 ( 0.89- 2.20) 1.30 ( 0.81- 2.10) 1.15 ( 0.67- 1.95) 1,42 ( 0.90- 2.24) ~ 1.17 (, 0.68- 2.01) Excluded/TiYndl 113 258 0.18 0.17 i 0.17 € 0.18 { € 0.19 POPULATION BASED STUDIES NE., 33CU<v13 13<S3CU<e2O 25<S3CU EXCludad/Trend~ 281 788 1.00 1.00 1.00 1.00 1.00 16 46 0.81 ( 0.43- 9.51) 0.78 ( 0.41- 1.49) 0.58 ( 0.27- 1.26) 0.81 ( 0.43- 1.53) 1.13 ( 0.55- 2.31)~ 19 29 1.41 ( 0.74• 2.68)~ 1.44 ( 0.75- 2.73) 1.20 ( 0.59- 2 44) 1.43 ( 0.75- 2.73) 1.54 ( 0.68- 3.47) ) 62 87 0.52 ~ 0.55 0.49 0.52 0.53 ~ HOSPITAL BASED STUDIES NE., =U<•13 13<S3CU<26 25<S3CU Excluded/Tr.nd1 36 14tiTHOUT OCCASIONAL SMOKERS NE., 53CU<.13 13<S3CU<•25 25<S3CU 40~ 1.32 ( 0.75- 2.31)~ 1.13 ( 0.59• 2.17) 291 1.44 ( 0.76- 2.73) 1.16 ( 0.57• 2.37) 751 0.18 0.19 1.00 0.74 1.13 ~ 0.16 1.00 ( 0.33- 1.64)1 1.42 ( 0.80- 2.50) 0.77 ( 0.39- 1.52) ( 0.50• 2.58)1 1.47 ( 0.77- 2.79)1 0.97 t, 0.46- 2.05) 0.18 1 0.18 330 786 1.00 1.00 1.00 1.00 1.00 30 71 0.90 ( 0.56- 1.45) 0.75 ( 0.44- 1.29) 0.63 ( 0.34- 1.15 ) 0.94 ( 0.58- 1.52) 0.72 i 0.40- 1.27) 28 47 1.21 ( 0.72- 2.03) 1.08 ( 0.62• 1.89) 1.12 ( 0.61- 2.05) 1.24 { 0.73- 2.08) 0.85 ( 0.45- 1.59) Excluded/Trondl 96 200 1 0.64 0.65 1 0.65 0.63 0.66 AGE <55 YEARS NE., 53CU<e19 13<S3CU<.25 25<s3CU 142 303 1.00 1.00 1.00 1.00 1.00 3 21 0.26 ( 0.07• 0.92) 0.24 ( 0.05• 1.10) 0.13 ( 0.02- 1.04) 0.27 ( 0.08- 0.97) 0.26 ( 0.05- 1.19) 5 5 2.53 ( 0.59-10.78) 1.86 ( 0.36- 9.57) 1.70 ( 0.33- 8.75) 2.84 ( 0.64-12.50) 2.70 { 0.23-31•54) Excluded/Trand~ 15 32 0.77 0.77 0.75 0.77 t 0.77 ~ AGE 55-&4 YEARS NE., S3CUu13 139 13<S3CU<25 17 25<S3CU 12 I 365 1.00 1.00 1.00 1.00 1.00 I 29 1.40 ( 0.70- 2.78) 1.04 ( 0.50- 2.20) 0.69 ( 0.28- 1.72) 1.37 ( 0.69- 2.73) 1.33 ( 0.57- 3.09) [ 16 1.95 ( 0.85- 4.51) 1.70 ( 0.71- 4.09) 1.61 ( 0.59• 4.37) 1.90 ( 0.82- 4.39) 2.09 ( 0.79- 5.49) t Exc1 udad/Trand 42~ ~ 122 0.08 0.08 ~ 0.09 ! 0.08 ~ 0.08 AGE 65+ YEARS NE., 83cuu13 166 13<S3C1.1<•25 21 25<S3CU 21 fxcluded/Trendl 67! HISTOLOGICALLY CONFIRMED DIAGNOSIS 307t 1.00 { 1.00 749 1•00 1 1.00 1 1.00 1.29 ( 0.70• 2.40) 1.16 ( 0.59- 2.26) 0.82 ( 0.36- 1.85) 1.20 ( 0.66• 2.19) 1.24 ( 0.67- 2.30) 1.14 ( 0.56• 2.33) 0.42 ~ 0.42 ~ 0.35 0.41 0.42 NE., S3CU<.13 433 1098 1.00 1.00 1.00 1.00 1.00 13<S3CU<•25 I 40 86 1,05 ( 0,69- i.60) 0.96 (, 0.61- 1.51) 0.64 ( 0.37- 1.10) 1.09 ( 0.71- 1.66) 0.93 ( 0.57- 1.52) 25<S3CU 36 l 58 1.35 ( 0.85- 2.13) 1.26 ( 0.78- 2.05) 1.17 ( 0.69• 1.98) 1.36 ( 0.86- 2.16) 1.19 ( 0.69• 2.04) Excluded/7rand *tB 303 .22 ~ 0.22 0.21 0.22 0.23 SQUAMOUS CELL CARCINOMA NE., S3CU<.13 75 13<S3CU<•25 ~ 9 25<S3CU 4 ~ zrcluded/Trend 21~ 1095 1.00 1.00 1.00 1.00 1.00 86 1.35 ( 0.61- 2.97) 0.91 ( 0.34- 2.43) 0.38 ( 0.09- 1.66) 1.39 ( 0.63- 3.06) 0.77 ( 0.26- 2•33) 58 0.93 ( 0•31• 2.76) 0.71 ( 0.21- 2.44) 0.76 ( 0.21- 2.66) 0.93 ( 0.31- 2.78) 0.55 ( 0.12- 2.45) 3031 0.82 0.82 f 0.75 0.81 0.82 SMALL CELL CARCINOMA S3CU<•13 NE., 45 1095 1.00 1. 00 1.00 1.00 1.00 93<S3CU<r 25 6 86 1.86 ( 0.71- 4.90) 1.55 1 0.55- 4.38) 1.32 ( 0.42- 4.21) 1.88 ( 0.71- 4.96) 1.58 ( 0.55- 4.50) 25<S3CU 2 8 0.72 ( 0.16• 3.29) 0.70 ( 0.15- 3.21) ~ 0.84 l, 0.18- 3.96) 0.70 ( 0.15- 3.21) 0.35 ( 0.04- 2.76) ~xcluded/Trend 17 ~ t 303 0.84 0.88 0.83 ~ 0.83 0.84 ADENOCARCINOMA NE., 33CU<•1a 13<S3CU<25 25<S3CU 235 1095 1.00 1.00 1.00 1.00 i 1.00 ~ 18 86 0.86 ( 0.49• 1.50) 0.80 ( 0.44- 1.47) 0.59 ( 0.29- 1.22) 0.89 ( 0.51- 1.56) 0.78 ( 0.41- 1.48) € 27p 58 1.80 ( 1.07- ^u.00) 1.70 ( 0.98- 2.93) 1.57 ( 0.86- 2.88)] 1.84 ( 1.10• 3.08) 1.59 (, 0.88- 2.90) c'XCludad/7rvnd~ 53~ 303 0.07 0.07 0.07 ~ 0.07 0.08 OTHER NE., 53cu<•t3 78 1095 1.00 1.00 t.oo ( 1.00 ( t.oo ) 13<S3CU<•25 7 86 0.98 ( 0.42• 2.26)' 1.13 ( 0.48• 2.66) 0.69 ( 0.23- 2.05) 1.02 ( 0.44• 2.37)1 1.13 ( 0.44- 2.87) 25<S3CU 3 58 0.64 / 0,19• 2.17) 0.66 ( 0.19- 2.26) 1 0.47 f, 0.11- 2.08) 0.65 ( 0.19- 2.20) 0.87 ( 0.25- 3.06) Excluded/Trend 271 3031 0.52 t 0.52 0.52 ~ 0.53 0.51 >75% OF LIFESPAN IN RURAL AREA OR INTERMEDIATE CITIES NE., u3CU<+13 167 368 1.00 1.00 13<S3CU<.25 ~ 19 261 1.55 ( 0.78- 3.08)i 1.55 ( 0.78• 3.08) 25«CU 14 15 1.76 ( 0.78• 4.01)I 1.76 ( 0.78- 4.01) Excluded/Trendl 56 a75SG OF LIFESPAN IN URBAN AREA 1661 0.08 E 0.08 NE„ :i3CU<.13 172 5522 13<S3CU<.23 ~ 11 48 1.00 1.00 1.00 1.04 { 0.42- 2.56)~ 1.61 ( 0.80- 3.23) 1.29 ( 0.63• 2.66) 1.90 ( 0.75- 4.79)~ 1.83 ( 0.80- 4.18) 1.33 ( 0.55• 3.23) 0.05 1 0.09 0.09 1.00 1.00 1.00 1.00 1.00 0.61 ( 0.30• 1.26 ) 0.61 ( 0.30- 1.26) 0.49 ( 0.22. 1.12) 0.65 ( 0.31- 1.33) 0.68 ( 0.29- 1.56) 25<S3CU i 17 i 36 1.25 ( 0.66• 2.36) 1.25 ( 0.66- 2.38) 0.96 ( 0 46• 2.02)~ 1.24 ( 0.65• 2.36) 1.40 ( 0.64• 3.03) fxcludad/7rand l 44 105 0.88 0.88 ~ 0•88 E 0.87 0.89 ~ (1) Model irlc(ude sex, center, sex'cantor and age 2063593430 (2) MoCal kxlude sex, centar, sax•centor, age and proponwn of residential type in the last 35 yrs (REUP) f3) A7odel »dude sex, t»nter, asx'ctnter, sge, propertion of residential type in the last 35 yrs (REUP) and educaLonal Isvel (EDUC) (4) Model ulUudo sex, center, sex•center, age and duration of exposure to list A agents (OCLAY) (5) Model InGude sex, oenter, sex'eenlor, age and frequency consumption of vegetables (VEGE)

S3AV Spouse and other cohabitants, Average exposure (cigarettes/day) P,tEN ONLY Total Mon C'SaS 154 Controts 566 Atl 737 ylancn Cases 0 Controls 0 AH 0 Ak Cascs 167 Controls 580 AN 737 Exposed Unexposed Exduded Min ~ P10 ~ C!1 Median 03 P90 Max ~ Mean Std 32 114 8 0.10 0.73 1.43 3.21 5.14 7.50 14.06 3.95 3.3 93 441 32 0.10 1.00 2.00 4.00 7.18 11.43 25.71 5.36 4.8 125 555 57 0.10 1.00 1.57 3.77 6.75 10.71 25.71 5.00 4.5 0 0 0 0 0 0 E 0 0 0 ~ ~ ~ ! t 1 32 114 11 0.10 0.73 1.43 3.21 5.14 7.50 14.06 3.95 3.3 93 441 46 0.10 1.00 2.00 ~ 4.00 7.18I 11.43 25.71 5.36 4.8 125 555 57 0.10 1.00 1.57 3.77 6.75/ 10.71 25.71 5.00 4.5 WOMEN ONLY Mcn COSC3 0 0 0 0 ~~6~593449 Contrds 0 0 0 0 AII 0 0 0 0 ~ won,rn c;ascs 527 260 177 90 0.05 1.50 2.69 5.68 10.09 20.39 61.69 8.65 9.5. Controls 950 504 312 134 0.05 1.50 3.00 5.62 11.08 18.34 60.00 8.16 7.7 All 1626 764 489 373 0.05 1.50 3.00 5.65 10.71 19.00 61.69 8.33 8.4 Afl CBsCs 650 260 177 113 0.05 1.50 2.69 5.68 10.09 20.39 61.69 8.65 9.5 ConttCls 1076 504 312 260 0.05 1.50 3.00 5.62 11.08 18.34~ 60.00 8.16 7.7 Alt 1626 764 489 373 0.05 1.50 3.00 5.65 10.71 19.00 61.69 8.33 8.4 POPULATiON BASED STUDIES Mdt CasCS Controls AII 91 444 535 21 78 99 63 340 403 ? 26 33 0.10~ 0.10 0.10 0.10 1.00 1.00 1.57 2.29 2.25 4.45 4.32 4.36 6.43 7.50 7.86 12.26 7.50 11.43 14.06 25.71 25.71 4.40 5.70 5.42 3.5 4.8'. 4.6 WattCn Ci7ses 287 132 100 55 0.05 1.50 2.54 5.02 9.31' 18.76 ~ 61.69 8.29 9.7' Controls 506 275 170 61 0.05 1.50 3.00 1 5.00 10.00 16.43 60.00 7.85 8.1: All 793 407 270 116 0.05 1.50 3.00 5.001 10.0017.10 61.69 7.99 8.6 All CESfs 378 153 163 62 0.05 1.50 2.50 4.79 8.87 16.58 61.69 7.75 9.2. Controls 950 353 510 87 0.05 1.29 2.93 5.00 9.29 15.38 ~ 60.00 7.38 7.5• A8 1328 506 673 149 0.05 1.30 2.71 4.96 9.26 15.72 61.69. 7.49 8.1 HOSPITAL BASED STUDIES Men Cases 47 11 35 1 0.73 1.081 1.14 2.22 3.43 5.00 10.43 3.08 2.7 Controls 73 14 54 5 0.20 0.23 1.18 2.36 5.00 5.29 20.00 3.81 5.0 All 120 25 89 6 0.20 0.73 1.18 2.25 4.29, 5.29 20.00 3.49 4.1 NofTlen CesQS 199 110 54 35 0.20 1.72 3.00 6.95 12.86 22.14 50.00 9.83 9.7. Canlrols 379 209 99 71 0.10 1.18 3.43 6.01 12.32 18.57 35.00 8.43 7.0 ' All 578 319 153 106 0.10 1.39 3.01 _ 6.29 12.55 19.31 50.00 8.91 8.0~ ,;tl sCS sC$ Ca 246 121 89 36 0.20 1.39 2.86 5.92 11.14 22.14 50.00 9.22 9.5 Controls 452 223 153 76 0.10 1.00 3.00 5.86 1 12.19 ~ 18.57 35.00 8.14 6.9! AIl 698 344 242 112 0.10 1.21 3.00 5.86 11.91 19.14 50.00 8.52 7.9- WITHOUT OCCASIONAL SMOKERS MCn C85CS `10 21 83 6 0.10 1.14 2.00 3.43 6.43 7.50 10. 43 4.17 2.9~ ContrOls 397 62 315 20 0.10 1.00 2.00 4.091 7.18 11.43 25.71 5.48 5.0< R11 ~a18 83 398 37 0.10 1.001 2.00 3.86 7.001 10.43 25.71 5.15 4.6, Women C~1,CS 419 199 141 79 0.10 1.50 2.83 5.29 10.00 20.00 53.31 8.40 9.0 Controls ~ 747 378 258 111 0.06 1.50f 3.00~ 5.621 11.25 18.57 60.00 8.27 7.9 All 1240 577 399 264 0.06 1.50i 3.00 5.57 10.71 19.05 60.00 8.31 8.3. _ All CASCS 542 220 224 98 0.10 1.50 2.68 5.071 10.00 19.31 53.31 8.00 8.7. Controls 1216 440 573 203 0.06 1.39 3.00 5.29~ 10.71 17.89 60.00 7.87 7.6 All '758 660 797 301 0.06 1.50 2.96 5.15 10.09 18.23 60.00 7.91 8.0 AGE t55 YEAR MM C8sC3 56 11 42 3 0.10 0.73 1.14 3.43 7.50 10.31 10.43 4.66 3.7 Contro;¢ 170 27 131 , 0.20 0.86 1.47 4.361 7.89 10.71~ 18.57 5.40 4.5: All 229 38 173 18 0.10 0.81 1.47 4.321 7.50 10.43 18.57 5.19 4.3 WOmCn CESCf 138 66 61 11 0.10 1.28 2.86 5.17 10.001 20.00 40.00 7.84 8.3 Contr0ls 254 125 108 21 0.10 1.18 3.01 20.00 40.00 6.43~ 12.19 8.87 7.7 All 392 191 169 32 0.10 1.24 3. 00 ~ 6.21 11.43 20.00 40.00 8.51I 7.9 AIl CasM 195 77 103 15 0.10 1.14 2.83 5.001 9.29 13.66 40.00 7.39 7.9 Controls 426 152 239 35 0.10 1.00 2.81 6.09 11.43 19.29~ 40.00 ~ 8.25 7.3 All 521 229 342 50 0.10 1.00 2.83 6.00 10.31 19.29 40.00 7.96 7.5 AG E SS-64 YEARS MOn Ce5e5 52 9 41 0.83 0.83 1.39 2.22 4.82 14.06 14.06 4.20 4.2 Controls 216 34 167 15 0.101 1.00 2.29~ 3.66~ 6.43 12.86 20.00 5.19 4.6 All 268 43 208 17 0.101 1.00 1.50 3.57 6.43 12.86 20.00 4.99 4.5 WOfT1Cq COSes 166 85 51 30 0.05 1.50 2.50 6.00 10.29 20.37 50.00 8.54 8.8 C~UOt3 304 164 88 52 0.101 1.50 3.05 5.79 10.21 15.38 41.71 7.82 6.5 AIl 535 249 139 147 0.05I 1.50 3.00 5.83 10.29 17.70 50.00 8.07 7.5 All C3sCS 226 94 92 42 0.05 1.391 2.25 5.07 10.29~ 19.49 50.00 8.13 8.6 Controls S75 198 255 122 0.10 1.50 3.00 5.11~ 10.00 15.16 41.71 7.37 6.6 Atl 803 292 347 164 0.05 1.50 2.64 5.07 10.00 15.72 50.00 7.61 7.2 AGE ES* YEARS Men Cises 45 12 31 3 0.10 0.10 1.79 3.21 4.64 5.00 5.291 3.10 1.8 Controls 180 32 143 5 0.91 1.00 2.13 4.09 7.25 11.43 25.711 5.51 5.4 All 240 44 174 22 0.10 1.00 2.00~ 3.88 5.28 8.43 25.71 4.85 4.8 :WOmmn Casos 223 109 65 49 0.20 1.55 2.86 5.71 10.71 21.88 61.69 9.23 10.7 ConU01s 392 215 116 61 0.05 1.29 3.00 5.14 10.86 18.11 60.00 8.02 8.4 A11 699 324 181 194 0.05 1.50 3.00 5.29 10.73 19.00 61.69 8.43 9.2 ~if C85CS 284 121 96 67 0.10 1.55 2.80 5.00 10.00 19.98 61.69 8.63 10.3 Controls 655 247 259 149 0.05 1.00 3.00 5.00 9.83 17.83 60.00 7.69 8.1 All 939 368 355 216 0.05 1.29 2.86 5.00 10.00 18.57 61.69 8.00 8.9

SITS Spouse, 777me since last EfS exposure (years) HISTOLOGICALLY CONFIRMED DIAGNOSIS Total Exoosad Unexposed Excluded I Min P10 01 Median 03 I P90 Max ( Mean Std MQt1 Gl3CS 152 23 129 0 0.00 / 0.00 0.00 1.00 19.00 29.00 41.00 8.17 12.60 ConlrolS 580 68 510 2 0.00 0.00 0.00 0.00 10.50 21.00 37.00 6.24 9.12 AI1 732 91 639 0.00 0.00 0.00 0.00 11.00~ 25.00 41.001 6.73 10.07 Wor110n C95o3 631' 302 210 19 0.00 0.00 0.00 ! 9.00 19.00 30.00) 52.00 11.62 11.77 Controlt 1076 632 420 24 0.00 0.00 _ 0.00 9.00 19.00 28.00 50.00 `:1.45 11.49 All 1607 934 630 43 0.00 0.00 0.00 9.00 19.00 29.00 52.00 11.51 11.58 AII CBsCf d83 325 339 19 0.00 0.00 0.00 8.00 19.00 30.00 52.00 11.38 11.85~ Controlb 1656 700 930 26 0.00 0.00 0.00 8.00 18.00 28.00 ~ 50.00 10.94 11.391 All 2339 10251 1269 45 0.00 0.00 0.00 8.00 19.00 28.00 52.00 11.08 11.53 SCIUAMOUS CELL CARCINOMA Men Ciso3 28 1 27 0 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 Controls 580 68 510 2 0.00f 0.00 0.00 0.001 10.50 21.00 37.00 ~ 6.24 9.12 All 608 69 537 2 0.00i 0.00, 0.00 0.00 10.00 21.00 37.00 6.15 9.08 W7Cn CiSC3 97 58 36 3 0.00 0.00 0.00 10.00 21.00 34.00 45.00 13.09 12.98 Controls 1076 632 420 24 0.00 1 0.000.00 1 9.00 19.00 28.00 50.00 11.45 11.49 Atl 1173 690 456 27 0.00 0.00• 0.00 9.001 19.00 29.00 50.00 11.59 11.63 A!1 Cases 125 59 63 3 0.00 0.00/ 0.00 10.00 21.00 34.00 45.00 12.86 12.98 COrttrols 1656 700 830 26 0.00 0.00 0.00 ~ 8.00 18.00 28.00 80.00 10.94 11.39 All 1761 759 993 29 0.00 0.00 0.00 ' 8.00 19.00 28.00 50.00 11.09 11.52 SMALL CELL CARCINOMA Men Cases 14 2 12 o D.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.001 Controls 580 68 510 -2 0.00 0.00 I 0.00 0.00 10.50 21.001 37.00 6.24~ 9.12 All 594 70 522 2 0.00 O.OO 0.00 0.00 10.00 20.50 37.00 6.06 9.05 WonSOrt CBSCf 67 38 27 2 0.00 0.00 ?.00 6.00 ?8.00 26.00 47.00 10.21 11.27 Conlrolf 1076 632 420 24 0.00 0.00 0.00 9.00 19.00 28.001 50.00 11.45 11.49 Afl 1143 670 447 26 0.00 0.00 0.00 9.00 19.OD '_8.00/ 50.00 11.38 11.48 Ap Cis@s 81 40 39 2 0.00 0.00 0.50 5.50 17.50 24.50 47.00 9-70 s1.20/ Controls ` 1656 700 930 26 0.00 0.00 0.00~ 8.00~ 18.00 50.00 28.00 10.94 ?1.39 A6 1737 740 969 28 0.00 0.001 0.00 8.00 18.00 1 27.50 50.00 10.88 11.37 Men Cases ~~ 61 15 65 0 0.00 0.00 0.00 3.00 19.00 29.00 41.00 8.80 13.24 Controls ~ 560 68 510 2 0.00 0.00 0.00 0.001 10.50 21.00 37.00 6.24 9.12 All 660 83 575 2 0.00 0.00 0.00 0.00j 11.00 25.00 41.00 6.70 9.94 WornCrl CSsoS 281 156 115 10 0.00 0.00 0.00 9.00 18.00 29.00 41.00 11.12 11.11 Controls 1076 632 420 24 0.00 0.00 0.00 9.00 19.00 28.00 50.00 11.45 11.49 All 13571 788 535 34 0.00 0.001 0.00~ 9.00/ 19.00 29.00 50.00 111.38 11.41 Atl CasCf 361 171 '.80 10 0.00 0.00 0.00 8.00 18.00 29.00 41.00 10.91 11.29 Conlrols 1656 700 930 26 0.00 0.00 0.00 8.00 18.00 28.00 50.00 10.94i 11.39 Alt 2017 671 1110 36 0.00 0.00 0.00 8.00 18.00 28.00 50.00 10.941 11.36 OTHER MCn C7SCS Controls AN 30 580I 610, 5 68 73 25 510 535 0 2 2 0.00 0.00 0.00 O.OOI . 1.00 0.00, 0.00 0.00 0.00 3.00 0.00 1.00 21.00 10.50 11.00 31.00 21.00 21.00~ 31.00 11.20 14.011 37.001 6.24~ 9.124 37.001 6.58f 9.4 f8 Womon CifCf 86 50 32 4 0.00 0.00 1.00 7.00 21.00 31.50 52.00 12.58 12.76 Controls 1076 632 420 24 0.00 0.00! 0.00 9.00 19.00 28.00 50.00 11.45 11.49 All I 1162 682 452 28 0.00 0.00/ 0.00 9.00 19.00 29.00 52.00 11.53 11.591 Al G9SCS 116 55 57 4 0.00 0.00 1.00 7.00 21.00 31.00 52.00 12.45 12.75 Controls I 1656 700 930 26 0.00 0.00 0.00 ~ 8.00 18.00~ 28.00 50.00 10.94 11.39 All 1772 755 987 30 0.00 0.00 0.00 8.00 18.00 28.00 52.00 11.051 11.49 >75h4 OF LIF€SPAN IN RURAL AREA OR INTERMEDIATE CITIES MCO 76 Cases " 69 0 0.00 0.00 0.00 3.00 29.001 31.00 31.00 9.43 14.13 ~ CGNfGf 225 ;4 <10 1 0.00 0.00 0.00 0.00 1 9.001 25.00 28.00 6.21 9.74 All 301 I 21 il 279 0.00~ 0.00 0.00 0.00 9.00 28.00 31.00 7.29 11.13 WomOn CasCS 237 137 97 3 0.00 0.00 0.00 7.00 18.00 30.00 47.00 11.22 11.86 Controls ~ 462 255 201 6 0.00 0.00 1.00 10.00~ 20.00 30.00 46.00 12.29 11.67 All 699 392~ 298 9 0.00 0.00 0.50 9.00 20.00 30.00 47.00 11.92 11.73 AII CiSCS 313 144 166 3 0.00 0.00 0.00 7.00 18.50 30.00 47.00 11.13 11.93 ConUdS ~ 687 289 411 7 0.00 0.00 1.00 9.00 20.00 29.00 46.00 11.98 11.64 All 1000 413 577 10 0.00 0.00 0.00 9.00 20.00 29.00 47.00 11.68 11.73 Men Cases 48 12 36 0 0.00 0.00 0.00 2.00 14.00 25.00 41.00 8.42 13.20 Contrds 257 40 216 1 0.00 I 0.00 0.00 0.00 12.00 20.50 37.00 6.25 9.50 A11 305 52 252 1 0.00 0.001. 0.00 0.00 12.00~ 21.00 41.00 6.75~ 10.37 WontCn Cases 196 118 67 11 0.00 0.001 4.001 11.50 22.00 31.00 52.00 14.161 12.18 ` ConlrGf 4541 301 140 13 0.00 0.00 0.001 8.00 17.00 28.00 45.00 11.08 11.31 ~ All 650 419 207 24~ 0.00 0.00 1.00~ 9.00 20.00 29.00 52.00 ?1.63 11.95 AIt C95t+3 244 130 103 11 0.00 0.00 3.00 10.50 21.00 30.50 52.00 13.63 12.34 ConllolS ~ 711 341 356 14 0.00 0.00 0.00 8.00 17.00 ~ 27.00 45.00 10.51 11.21 Alt 955 471 459 25 0.00 0.00 0.00 9.00 19.00 28.00 52.00 11.371 11.60 2063593417

m237 6V ehiclesa. Descriptive statistics of quantitative variables

® -S3A\/ Spouse and other cohabitants, Average exposure (cfgarettes/day) MEN ONLY `.vo1 at oxnon~ro Csaea NE., ,`i3AV<.1 127 1<S3AV<u 1 3 1<S3AV 0 Controls OR('1 95X CI OR(2) 95% Ct ( OR(3) 95% CI ( OR(4) 95% CI OR 5 95% Cf I 474 1.00 1.00 ( 1.00 ° 1.00 1.00 8 1.54 ( 0.30• 8.02) 1.48 ( 0.23- 9-54) 1.40 ( 0.11-18.59) 1.56 ( 0.29- 8.28) 1.80 ( 0.24-13.37) 4 0.00 ( 0.00-99.99) 0.00 ( 0.00-99-99} 0.00 ( 0,00-99,99) 0.00 ( 0.00-99.99) 0.00 ( 0.00-99.99) E L~cluded/Trend 11 45 0.83 0.83 0.84 0.83 0.82 ~ WOMEN ONLY HE., ."i3AV<1 332 621 1<S3AV<it 30 77 1<S3AV 34 55 1.00 1.00 1.00 1.00 1.00 0.69 ( 0.44- 1.10) 0,60 ( 0,36- 0,99) 0.59 ( 0,33• 1,04) 0.70 ( 0.44- 1.10) 0.55 ( 0.32- 0.94) 1.22 ( 0.77- 1.93) 1.13 ( 0.70- 1,84) 1.19 l, 0.67- 2.09) 1.23 ( 0.77- 1.96) 1.00 ( 0.58- 1.74) Excluded/Trand f13 258 0.95 0.93 1 0.96 0.95 ~ 0.99 POPULATION BASED STUDIES HE., S3AV<1 285 784 1.00 1.00 1.00 1.00 1.00 1<S3AV<.1 17 50 0.70 { 0.36- 1.28) 0.74 ( 0.40- 1.34) 0.69 ( 0.35- 1.39) 0.71 ( 0.39- 7.29) 0.77 { 0.39- 1.50) 1<S3AV 14 29 1.03 ( 0.51- 2.08) 1.05 ( 0.52- 2.13) 1,04 ( 0.47- 2•31) 1.04 ( 0.52- 2.09) 0.98 ( 0.41- 2.32) ExCludld/Trend 62 871 0.56 0.56 0.62 ) 0.55 0,56 }fOSPrrAL BASED STUDIES NE., S3AV<1 1<S3AV<1 t<S3AV 17a 311 1.00 1.00 1.00 1.00 1.00 18 35 0.78 ( 0. 41- 1.49) 0.48 ( 0.20- 1,15) 0.50 ( 0.19- 1.28) 0.77 ( 0.40• 1.48) 0.41 ( 0.17- 0.96) 20 30 0 . 1.34 { 72- 2.47) 1.12 ( 0.58• 2,18) 1.29 ( 0.58- 2.87) 1.35 ( 0.73- 2.50) ~ 0.98 ( 0.48- 2.00) Ercluded/Trend 36 76 0.65 0.67 0.66 ~ 0.65 ) 0.59 ~ SNiTHOUT OCCASIONAL SMOKERS NE., S3AV<1 339 794 1.00 1.00 1.00 1.00 1.00 1<S3AV<1 25 67 0.69 ( 0.41- 1.15) 0.52 ( 0.29- 0.94) 0.55 ( 0.30- 1.03) 0.69 ( 0.42- 1.15) 0.47 ( 0.25- 0.88 ) 1<S3AV 24 43 1.08 ( 0.63- 1.88) 0.98 ( 0.55- 1.76) 1.00 ( 0.52• 1.94) 1.10 ( 0.63- 1.90) 0.82 ( 0.42- 5.57) Excluded/Trend ~ ' 98 200 0.62 0.63 0.65 0,62 0•63 ~ AGE <55 YEARS N€., S3AV<.1 1<S3AV<1 i<S3AV 136 289 1.00 1.00 1.00 1.00 1.00 7 21 0.63 ( 0.25- 1.61) 0.54 { 0.17• 1,73) 0.64 ( 0.19- 2.15) 0.66 ( 0.25- 1.70) 0.69 ( 0.20- 2.31) 7 19 0.68 ( 0.27- 1.75) 0.48 ( 0.16- t•40) 0.61 ( 0.18- 2•12) 0.71 ( 0.28- 1.83) 0.48 ( 0.15- 1.59) Exclud®diTrend 15 32 0.26 0.23 0.22 t 0.26 0.26 AGE 55•64 YEARS NE., .i3AV<1 144 384 1.00 1.00 1.00 1.00 1.00 1<S3AV<.1 12 32 0.78 ( 0.37- 1.67) 0.50 ( 0.20- 1.22) 0.47 ( 0.18- 1.26) 0.77 ( 0.36- 1.64) 0.61 ( 0.24- 1.53) i<S3AV 92~ 14 2.11 (, 0.90• 4.96) 1.98 ( 0.82- 4.76) 2.24 ( 0.70- 7.14) 2 05 ( 0.88- 4.82) 1.82 ( 0.70- 4.73) ExCluded/Trandi 4$~ 122 0.30 0.30 ~ 0.29 0.30 0.29 AGE B6+YEARS NE., S3AV<1 179 422 1<S3AV<1 14 32 1<S3AV is 26 Excluded/Trendl 671 ?491 HISTOLOGICALLY CONFIRME D DIAGNO SIS NE., :33AV<1 444 1095 1<S3AV<1 33~ 85 1<S3AV 32 59 Excluded/Trendl SQUAMOUS CELL CARCINOMA f18 303 HE., 53AV<1 74 1095 1<83AV<1 T 9 85 1<S3AV I 5 59 Excl uded/Trend SMALL CELL CARCINOMA NE., S3AV<•1 1<S3AV<1 1<S3AV 0.42 0.51 0.48 49 loss 1.00 1.00 1.00 1.00 i 1.00 2 85 0.44 ( 0.10- 1.91) 0.47 ( 0.11- 2.06) 0.54 ( 0.12- 2.43) I 0.43 ( 0.10- 1,90) 0.22 ( 0.03- i.65) 2 59 ~ 0.61 ( 0.14• 2. 7) 0.60 ( 0.13- 2.72) ~ 0.74 ( 0.16- 3.48 )F1( ~ 0.61 ( 0.13- 2•74) 0.62 ( 0.14- 2.86) Exclud.d/rrrnd 17 303 0.27 ~ 0.28 E 0•30 ~ 0.28 i 0.28 ~ ADENOCARCINOMA NE., S3AV<1 1<S3AV<1 1<S3AV 244 1095 1.00 1.00 1.00 1.00 ~ 1.00 15 65 0.60 ( 0.34- 1.09) 0.56 ( 0.29- 1.06) 1 0.45 ( 0,20• 0.97) 0.61 ( 0.34- 1.09)~ 0.56 ( 0.29- 1.09) 21 69 1.28 ( 0.74- 2.21) 1.19 ( 0.66- 2.12) 1.45 ( 0.76- 2.76) 1.29 { 0.75- 2.23)1 1.09 ( 0.58- 2.07) ! c'kcludod/Trrnd l 63~ 3031 0.92 0.92 ~ 0.94 0.91 ~ 0.95 OTHER NE., :3AV<1 1<S3AV<a1 1eS3AV '7 10951 1.00 1.00 1.00 1.00 1•00 7 85 0.95 ( 0.41- 2.18) 0•93 ( 0.38- 2.27) 0.98 ( 0.36- 2.65) 0.95 ( 0.41- 2.20) 1.04 ( 0.42- 2.61) 4 59 0.90 ( 0.31- 2 62) 0.90 ( 0.31- 2.66) 0.56 ( 0.13• 2.47) 0.90 ( 0.31• 2.62) 1.15 { 0.38- 3•46) ) fxcluded/Tr:ndl 57 303 0.82 ~ 0.80 0.80 t 0.82 0,82 >759L OF LJFESPAN IN RURAL AREA OR INTERMEDIATE CITIES HE., u3AV<1 177 366 1,00 , 1-00 1,00 1-00 1,00 1<S3AV<1 ~ 9 26 0.52 ( 0.22- 1.18) 0.52 ( 0.22- 1.18) 0.53 ( 0.21- 1.31) 0.52 ( 0.23- 1.20) 0.49 ( 0.21- 1.13) 1<S3AV 141 17 1.61 ( 0.73- 3.54) 1.61 ( 0.73- 3.54) 2.53 (, 0.88- 7.26) 1.68 ( 0.76- 3.71)I 1.23 ( 0.50- 2.98) Excluded/TrendI 561 P661 0,82 ~ 0.82 f 0.72 ~ 0.83 0.81 >7g5L OF LIFESPAN IN URBAN AREA HE., "u3AV<1 1<S3AV<1 1<S3AV 175 S29 1.00 1 .00 1.00 1.00 1.00 11 44 0.65 ( 0.32- 1.34) 0.65 ( 0.32• 1.34) 0.55 ( 0.24- 1.25) 0.61 ( 0.30- 1.26) 0.66 ( 0.29- 1•49)1 14 33 1.13 ( 0.57- 2.25) 1.13 ( 0.57- 2.25) 1.06 ( 0.49- 2.30) 1.09 ( 0.55- 2.17) 1.24 ( 0.55• 2.80) c"xcluded/Trond 44 105 0.80 0.80 0.80 E 0.74 1 ~ 0•87 (1) Modet inckudo sex, oenter, sex'center and age (2) Mode( k)cklde ssx, ccnter, sex'canter, age and proportion of residential type in the last 35 yrs (REUP) (3) Model ;nckxia sox, conter, sex'oenter, sQe, proportion of residential type in the last 35 yrs (REUP) and educational level (EDUC) 1.00 1.00 1.00 1.00 1.00 0.77 ( 0.39- 1.53) 0.79 ( 0.39- 1.60) 0.71 (, 0.30- 1.67) 0.78 ( 0.39• 1.53) 0.58 ( 0.27- 1.22) 1.30 ( 0.64- 2.63) 1.31 ( 0.63- 2.73) 1.39 ( 0.62- 3.11) 1.29 ( 0.64- 2.60) 0.96 ( 0.41- 2.24) € 0.81 0.82 ~ 0.72 0.81 ~ 0.78 1.00 1.00 1,00 1.00 1.00 0.74 ( 0.47- 1.14) 0.64 ( 0.39- 1.04) 0.61 ( 0.35- 1.05) 0.74 ( 0•48- 1.15) 0.60 ( 0.35- 1.00) 1.16 ( 0.72• 1.85) 1.08 ( 0.66- 1.77) 1.17 (, 0.67- 2.05) 1.16 ( 0.73- 1.86) 0.99 ( 0.57- 1.71) 0.85 0.85 0.88 0.85 0.88 :~'J63593434 j4) Mod®1 fnelude sex, c»nter, swCenfer, apc and duralion of rxposure to list A agents (OCLAY) (5) Model indude sex, center, sox'center, age and frequency consumption of vegetables (VEGE) Risk estimates - Spouse and other cohabitants

O_'dVOUD Workplace, Duration (years) (non overlapping) Levei of exposuro Cas os Controls OR(1) 95Y. CI OR(2) 95•/. CI j OR(3) 95Y. CI OR(4) 95'/. CI OR(5) 95% CI _p Non exposed 276 687 1.00 1.00 1.00 1.00 1.00 0<WOUD<29 278 634 1.15 ( 0.91- 1.44) 1.10 ( 0.87- 1.40) 1.09 ( 0.83- 1.43) 1.13 ( 0.90- 1.43) 1.06 ( 0.82- 1.37) 29<WOUD<38 55 129 1.26 ( 0.85- 1.85) 1.36 ( 0.91- 2.04) 1.36 ( 0.85- 2,17) 1.20 ( 0.81• 1.78) 1.24 ( 0.80- 1.90) 38<WOt)D 39 91 1.19 ( 0.76- 1.86) 1.02 ( 0.62- 1.68) 0.70 ( 0.38- 1.29) 1.21 ( 0.77- 1.91) 1.03 ( 0.62- 1.71) €xcluded/Trend 2 0.21 0.21 0.17 0.21 0.19 ALL CENTERS W)TH EDUCAT iONAL LEVE L AND TYPE OF RES IDENCE Non exposeo 195 523 1.00 1.00 1.00 1.00 7.00 0<'h'0UD<29 182 472 1.07 ( 0.82- 1.40) 1.06 ( 0.81- 1.39) 1.09 ( 0.83- 1.43) 1.04 ( 0.79- 1.36) 1.02 ( 0.77- 1.37) 29<YfOUD<38 38 96 1.32 ( 0.83- 2.10) 1.31 ( 0.82- 2.10) 1.36 ( 0.85- 2.17), 1.24 ( 0.77- 1.99) 1.21 ( 0.73- 2•01) 38<WOUD 16 68 0.68 ( 0.37- 1.26) 0.68 ( 0.37- 1.26) 0.70 ( 0.38- 1.29) I 0.69 ( 0.38- 1.28) 0.74 ( 0.39- 1.38) €xcluded/Trond 67 179 1.00 ~ 0.95 0.85 ( 1.00 0.97 ALL CENTERS WITH DIETARY DATA Non exposotl 196 0001.10<29 230 29<N'OU0<38 45 38<WOUD 29 Excluded/Trend 9 FRANCE 408 1.00 1.00 1.00 1.00 1.00 474 1.06 ( 0.82- 1•37) 1.05 ( 0.80- 1.37) 1.04 ( 0.78- 1.39) 1.04 ( 0.80- 1.35) 1.06 ( 0.82- 1.37) 89 1.21 ( 79- 1.87) 0. 1.27 ( 0.82• 1.97) 1.22 ( 0.74- 2.03) 1.15 ( 0.74- 1.78)1 1.24 ( 0.80- 1.90) 1 64 1.03 ( ~ 62- 1.71) 0 . 1.00 ( 0.59- 1.70) 0.73 { 0.39- 1.38) 1.04 ( 0.62- 1.74) 1.03 ( 0.62- 1.71) 21 0.56 0,60 0.54 1 0.61 0.53 Non OXpOEetl 38 78 1.00 1.00 1.00 1.00 i,00 0<Yf0U0<29 29 59 0.97 ( 0.53• 1.79) 0.88 ( 0.44- 1.76) 1.02 ( 0.42- 2.45) 0.96 ( 0.52- 1.79)1 0.96 ( 0.52- 1.78) 29<WOUD<38 5 10 1.07 ( 0.33- 3.44) 1.15 ( 0.34- 3.91) 2.55 ( 0.42•15.27) 1.03 ( 0.32- 3.35) 1.06 ( 0.33• 3.44) 30<Wpt}0 3 4 1.58 ( 0.32- 7.84) 1.23 ( 0.20- 7.71) 0.73 ( 0.07- 7.77) ( 1.52 ~ . 30- .30- 7.61) D 1.56 ( 0.31- 7.77) €xcluded/Trend 2 0 0.72 0.76 t 0.69 0.78 , 0.73 GERMANYI Non exposotl 0<WOl}D<29 29<yrpUD<38 30<WOUD €zc1 uded/Trend GERMANY2 Non exposeo 1 19 46 1.00 1.00 1.00 1.00 E, 1.00 44 133 0.97 ( 0.49- 1.92) 1.05 ( 0.50- 2.21) 1.05 1 0.49- 2.23) 0.94 ( 0.46- 1.91) 1.16 ( 0.57• 2.35) 7 30 1.15 ( 0.39- 3,36) 1.49 ( 0.48- 4.64) 1.37 ( 0.43- 4.31) 0.96 ( 0.30- 3.05)~ 1.40 l, 0.47- 4.17)' i 6~ 20 1.11 ( 0.35- 3.50) 0.85 ( 0.22- 3.27) 0.83 ( 0.21- 3.24) 1.06 ( 0.33- 3.41) 0.97 ( 0.28• 3.29)~ 0 0 0.76 0.86 0.93 0.84 ~ 0.76 64 62 1.00 1.00 1.00 1.00 t t.0o 29 0<µ1pUD< 60 64 0.97 ( 0.58• i.63) 1.04 ( 0.61- 1•77)1 1.03 ( 0.61- 5.76) 0.98 ( 0.58- 1.64) 1.00 { 0.59- 5.67) 29<Wp()O<r38 12 22 0.67 ( 0.29• 1.53) 0.68 ( 0.29- 1.56)) 0.73 ( 0.31• 1.70) 0.67 ( 0.29- 1.53) 0.69 ( 0.30- 5.57) 38<WOUD 6 15 0.56 ( 0.20- 5.62) 0.57 ( 0.20- t•66)1 0.56 ( 0.19- 1.62) 0.56 ( 0.19- 1.61) 0.58 ( 0.20- 1.67) :'xcluded/Trond 0 0 0.19 ( 0.20 ) 0.23 0.19 0.19 GERMANY3 Non exposed O<y/OUDc29 29<W0U0<38 38<WOUo cxcluded/Trand! 13 28 1.00 1.00 1.00 1.00 1.00 11 21 1.27 ( 0.43- 3.77) 1.30 ( 0.44- 3.88) 1.27 ( 0.41- 3.94) 0.83 ( 0.26- 2.68) 1.35 ( 0.44- 4.14) S 2 6.83 ( 0,87•53•26) 8.55 ( 0.99-74.13) ' 5.68 ( 0.60-54.22) 4.71 ( 0.54-41.36) 7.46 ( 0.86•64.71)1 2I ? 4.52 ( 0.34-59.94) 5.18 ( 0.37-71.85) 4.88 ( 0.34-70.27) 3.60 ( 0.27-47.34) 8.43 ( 0.58-122.0 !i) Pf 0 0.05 v 0.04 0.09 {{{ 0.11 0.03 !!! ITALY 1 Non exposetl t 22 108 1.00 1.00 1.00 1.00 0<WOUD<.29 14 I 81 1.09 ( 0.48- 2.46) 1.34 ( 0.57- 3.12)I 1.35 ( 0.57- 3.18) ~ 1.07 ( 0.46• 2.49) 29<WOUD<38 3 20 1.22 t 0.30- 5.06) 1.34 ( 0.32- 5,62) 1.40 /, 0.33- 6.01) 1.18 ( 0.28- 4.95) 38<WOUD ( 1 12 0.66 ( 0.08• 5.75) 0.92 ( ~ 0.10- 8.31) 0.00 ( ~ 0.00-99.99) 0.65 ( 0.07• 5.79) €xcluded/ Trend~ 0 0 0.98 0.94 I 0.94 1 0.92 ITALY 2 Non exposad 10 100 1.0o 1. 00 1.00 1.00 0<WOUD<29 5S 2.55 ( 0.77- 8.42) 1.98 ( 0.50- 7.88) 2.75 ( 0.49•15.34) 2.28 ( 0.67- 7.75) 29<YpUD<38 2 11 8.40 ( 5.12-63.21) 30.98 ( 2.16-99.99) 66.09 ( 2.57-99.99) 8.65 ( 1.09-68.78) 38<VYOUD 0 11 0.00 ( 0.00-99.99) 0.00 ( 0.00-99.99) 0.00 ( 0.00•99.99) 0.00 ( 0.00-99.99) Ezcluded/Trend Oi 0 0.16 0.07 0.06 0.18 ~ ITALY 3 Non axpoaaa 15 35 1.00 1.00 1.00 1 1.00 1.00 0<H'OUD<29 1 11 0.14 ( 0.01- 2.35) 0.12 ( 0.00• 2.93) 0.24 ( 0.02- 3.01) 0.14 ( 0.07• 2.61) 0.17 ( 0.01• 2.93) 29<WOUD<38 0 2 0.00 ( 0.00-99.99) 0.00 ( 0.00-99,99) 0.00 ( 0.00-99.99)1 0.00 ( 0.00-99.99) 0.00 ( 0.00-99.99) 38<WOUD 0 1 2 0.00 ( 0.00-99.99) 0.00 ( 0.00•99.99) 0.00 ( 0.00-99.99) 0.00 ( 0.00-99.99) 0.00 ( 0.00-99.99) €zc1 udod/Trond 0 0 0.16 0.17 0.1 8 0.18 0.76 PORTUGALI Non exposeC 19 24 1.00 0<Yt0U0<29 ~ 19 8 3.81 ( 1.10-13.21) 4.60 ( 1.25-16.85) zacnuuucon y 5 1.11 ( 0.24• 5.16) 1.05 ( 0.23- 4.86) 30<WOUD 7 4.06 ( 0,71-23.06) 4.03 ( 0.71-22.73)i Excluded/Trend 0 0 0.21 1 0.21 ~ PORTUGAL 2 Non expOS9d ( 23 39 1.00 1.00 ~ 1.00 0<y{OUOu29 ( 8 ?t 1.45 ( 0.47- 4.49) 1.40 ( 0.41• 4.73) E 1.63 1 0.52- 5.13) 29<WOUO<38 ! 1 2'! 0,98 ( 0.08•12,15) 0.68 ( 0.05- 9.39) 1.09 1 0,09-13.58) 1 38<YfOUD € 1 S ! ^< • 04 •04 ( 0.10-39.89) 1.57 ( 0.08•31.38) ~ 2.24 ( 0.11-44.17) fxcluded/TrSndl 0 Of 0,61 0.71 0.51 . SPAIN Non ®xposao 32 84 1.00 1.00 1.00 1.00 1.00 0<YtOUD<. 29 32 55 1.54 ( 0.83- 2.88) 1.48 ( 0.77- 2.83) 1.53 ( 0.79- 2.98) 1.53 ( 0.82- 2.86) 1.72 ( 0.91- 3.26) 29<140U0<38 4 9 1.17 ( 0,31- 4.37) 1•35 ( 0.35- 5.30) 1.23 ( 0.30- 4,96) 0.84 ( 0.19• 3.53; 1.29 ( 0.34- a.93) 38<140UD 3 10 0.84 ( 0.21- 3.47)1 0.99 ( 0.24- 4.13) 1.01 ( 0.24- 4.24) 0.98 ( 0.24- 4.08)~ 1.13 ( 0.27- 4.82) €xc1 udcd/Trend l Of 1 0.85 0.75 0.74 € 0.85 0.53 E SWEDEN Non exposeo 8 21 t.oo 1.00 f . 100 1.00 ( O<WOUO<29 42 3 1.86 ( 0.71- 4.83) 2.01 ( 0.76- 5.30)1 I 1.74 ( 0.67- 4.54) 7.92 ( 0.73- 5.03)i 29<WOUD<30 10 10) 3.09 ( 0.90•10.59) 3.06 ( 0.89-10.56) ` 3.06 ( 0.90-10.43) 3.49 ( 1.00-12.15)~ 38<IYOl10 10 8j 3.24 ( 0.87•12.07) 3.05 ( 0.81-11.50) I 2.80 ( 0.73-10.65) 3.30 ( 0.87-12.52) °€se1 uded/Trend 0 OI 0.04 0.06 ~ 0.06 0.03 ~ UNfTED KINGDOM Non exposed 0<1101.10<29 29001.10<38 38<WOUD €zc1 uded/Trond 13 62 1.00 1.00 1.00 1.00 1.00 11 67 0.71 ( 0.28- 1.76) 0.70 ( 0.28- 1.76) 0.72 ( 0.28- 1.84) 0.56 ( 0.21. 1.50)0.68 ( 0.27- 1.70) 2 61 1.52 ( 0.27• $.72) 1.24 ( 0,20• 7.59) 1.40 ( 0.23- 8.54) 2.12 ( 0.33-13,68) 1.61 ( 0.28- 9.23) 0 51 0.00 ( 0.00-99.99) 0.00 ( 0.00-99.99) 0.00 ( 0.00-99.99) 0.00 ( 0.00-99.99} 0.00 ( 0.00-99.99)I 0 01 0.63 ~ 0.54 0.57 0.62 0.63 (1) Moda( Include sex, ccnter, sex'ccnter and age (2) Model tneludo sex, center, sex'center, age and proportion of residentia(type in the last 35 yrs (REUP) (3) Model )nGude sex center. sex•center• age. proportlai of residential type in the last 35 yrs (REUP) and educational level (EDUC) (4) Model includ® sex, center, sex'cenler, age and duration of exposure to list A agents (OCLAY) (5) Model Include sex, eenter, sex'center, age and frequency consumption of vegetables (VEGE) ---°- - 40b3593458

WOUD Workpface, Duration (years) (non overlapping) HISTOLQGICALLY CONFIRMED DIAGNOSIS To1al Exoozcd Unexoosed Excluded Min P10 ~ Q1 f Median { 03 P90 ~ Max Mean ~ Std ~ Men C:25C4 152 104 47 1 2.00 6.00 14.00 23.50 35.00 43.00 54.00 24.05 i3.07 Controls 580 388 192 0 0.50 5.00 10.501 23.00 34.00 40.00 56.00 ~ 22,77 13.47 AN 732 492 239 1 0.50 5.00 11.00 23,00 34.00 41.00 56.00 23.04 13.39 WOmCr1 CaSC3 $31 262 268 1 0.50 4.00 8.00 15.00 25.00 35.00 55.00 17.52 12.47 Ir0S 1076 476 599 ~ 0.50 3 00~ 6.00 12.00 21.50 33.00 54.00 15.35 11.76 l A 1607 736 867 2 4.50 : 5'00f, 6.00 13.00 24.00 34.00 55.00 16.12 12.05 Ai! CaSC9 683 366 315 2 0.50 4.00 8.00 17.00 29.00 38.00 55.00 19.38 12.96 CC(tU01S 1656 864 791 1 0.50 3.00 7.00 15.75 29.00 38.00 56.00 18.68 13,09 All 2339 1230 i106 3 0.50 3.00 8,00 16.00 29.00 38.00 56.00 18.89 13,05 3QUAMOUS CELL CARCINOMA MC11 C35C3 28 18 10 0 3,00 4.001 7.00 21.50 36.00 I 44.00 52.00 22.33~ 15.01 - COntt01S 580 388 192 0 0.50 5.00 10.50 23.00 34.00~ 40.001 56.00 22.77 13,47( AN 600 l 406 202 0 0.50 5.00 10.00 23.00 34.00 40.00 56.00 22.75~ 13,521 WOOk7i M 97 48 49 0 0.50 4.00 8.50 18.50 32.00 39.00 52.00 20.17 13.80 COntt015 1076 476 599 1 0,50 3.00 6.00 12.00 21.50 33.00 54.00 15.35 11.76 AH 1173 524 648 1 0.50 3.00 6.00 12.00 23,00 34.00 54.00 15.79 12.03 A(1 C43CS 125 66 59 0 0.50 4.00 8.00 20.50 32.00 3.00 52.00 20.76 14,06 Controls 1656 864 791 1 0.50 3.00 7.00~ 15.75 29.001 38.00 56.00 18.68 13.09 All 1781 930 a50 11 0.50 3,00 7.00 16.00 29.0038.00 56.00 18.83 13.16 SMALL CELL CARCINOMA MCl1 C3309 14 11 3 0 2.00 6.00 14,00 27.00 36.00 37.00 38.00 24.27 12,53 Controls 580 388 192 0 0.50 5.00 10.50 23.00 34.00 40.00 56.00 22.77 13.47 All 594 399 195 0 0.50 5.00 11.00 23.00 34.00 40.00 56.00 22.82 13.44 WOrtsQf1 C85CS 67 31 36 0 1.00 3.00! 5.00 12.00 23.00 35.00 49.50 15.02 1 12.57 Controls 1076 476 599 1 0.50 3.00f 6.001 12.00 21.50 33.00 54.00 15.35' 11.76 All 1143 507 635 1 0.50 3.00 6.00 2.00 22.00 33.00 54.00 15.33 11.80 A(i Ca3C5 81 42 39 0 1.00 3.00 6,00 13.50 27.00 37.00 49.50 17.44 13.07 Controls 1656 864 791 1~ 0.501 3.00 7.00 15.75 29.00 38.00 56.00 18.68 13.09 All 1737 906 830 f 0.50 3.00 7.001 15.00 29.00 38.00 56.00 18.62 13.08 ADENOCARCINOMA MCn C4SCS 80 52 7 1 2.00 8.00 16.00 20.50 29.50 43.00 54.00 23.10 12.58 Controls 500 388 192 0l 0.50 5.00 10.50 23.00 34.00 40.00 56.00 22.77 13.47 A}I 660 440 19 1 0.50 5.00 11.00 22.50 34.00 41.00 56.00 22.81 73.36~ WOrtiCdi C35@S 281 134- 146 1 1,00 4.00 8.00 16.00 27.00 35.00 55.00! 17.82/ 12.29 Controls 1076 476~ 599 1 0.50 3.00 6.00 12.00 21.50 33.00 54.00 15.35 11.76 AU 1357 610 745 2 0.50 3.00 6.00 13.00 23.00 34.00 55.00 15.89 11.92 All COiCi 351 186 1731 2 1.00 4.00 9.00 17.00 28.00 38.00 55.00 19.29 12.57 Controls 1656 864 791 1 0,50 3,00 ' 00 15.75 29.00 38.00 56.00 18,68 ~ 13.09 All 2017 1050 964 3 0.50 3.00 8.00 16.00 29.00~ 38.00 56.00 18.79 12.99 OTFER MCn C2SQS 30 23 " 0 4.00 8.00 17.00 31.00 39.00 41.00 49.00 27,46 13.08 Controls 380 388 192 0 0.50 5.00 10.50 23.00 34.00 40.00 ~ 56.00 22.77 13.47 AII 610 411 199 0 0.50 5.00 11.00 23.00 34.00 40.00 56.00 23.04 13.48 WOrMn C7seE a6 49 37 0 2.00 3.00 8.00 13.00 <^1.00 32.00 51,00 15.72 11.25 Controls 1076 476 599 1 0.50 3.00 6.00 12.00 21.501 33.00 1 54.00 15.35 11.76 All 1182 525 636 0.50 3.00 6,00 12.00 21.00 33.00 54.00 15.38 11.71 AII CaSCS 116 72 44 0 2.00 4.00 9.00 17.00 29.50 39.00 51.00 19.47 13.00 Controls :656 884 791 1 0.50 3.00 7.00E 15.75 29.00 38.00 56.00 18.68 1 3.091 All 772 936 835 1 0,50 3.00 7.00 16.001 29.00 38.00 56-00 18,74 13.07 >75X OF LIFESPAN IN RURAL AREA OR INTERMEDIATE CITIES t.1t11 C85CS 76 39 37 0 2.00 3.0D 32.00 7.00~ 21.00 43.00 52.00 21.23 14.09 COOtlot3 225 128 97 0 0.50 4.00 1 10.00~ 21.50 35.00 41.00 52.00 22.86 14.071 All 301 167 134 0 0.50 4.00 10.00 21.00~ 35.00 41.00 52.00 22.48 14.05 WOrtlCtl Cases 237 95 141 1.00 3.00 6.001 12.00 24.00 33.00 43.00 15.47 11.25 Controls 462 191 271 0 0.50 2.00 4.00'E 11.00!' 21.00 29.00 51.00 13.73 10.96 All 699 286 412 1~ 0.50 2.00 5.001 ?1.501 2^_.00 31.00 51-00 14-31 11.06 NI IC3Se5 313 134 17® 1 1.00 3.00 5.00 13.50 28.00 35.00 52.00 17.15 12.37 Controls 687 319 368 0 0.50 3.00 6.00 14.00 28.001 38.00~ 52.00 17.39 13.07 All 1000 453 546 0.50 3.00 6.00 14.00 28.00 37.00! 52.00 ?7.32 12-85 >75% OF LIFESPAN IN URBAN AREA MOtI C.l.SCS 40 41 7 0 4.00 11.00 19.00 27.00 38.00 44.00 $4.00 27.76 12.53 Controls 257 185 72 0 1.00 6,00 12.00 25.00 34.00 40.00 56.00 23.59 13.32 All 305 226 79 0 1.00 6.00 13.00 25.50 35.00 41.00 56.001 24.35 13.25 WOn1En Cm5@f 996 109 87 01 0.50, 4.00 8.00 17.00 28.00 37.00 52.00 19.30 12.79 Controls 454 203 250 1 1.00 4.00 7.00 14.00 22.00 36.00 I 54.00I ~ 16.51 12.36 All 650 312 337 1 0.50 4.00 7.00 14.50 25.50 36.00 54.00 17.48 ?2 56 AIl CiSES 244 160 94 0 0.50 4.50 10.00 20.50 32.00 41.00 $4.00 21-61 13.23 Controls 711 308 322 1 ',.00 4.00 8.00 17.00 32.00 39.00 56.00 19.89 E 13.29 Alt 11 955 538 416 1 0.50 4.00 9.00 18.00 32.00 39.00 S6.00 20.37 13.28 2-06J.,79J"t7G?

S3TS Spouse and other cohabitants, Time since last exposure (years) HISTOLOGICALLY CONFIRMED DIAGNOSIS Total Expo,•€d Unexposed Exdutled ! Min P10 C]1 Median 03 P90 Max Mean d E j St M€n CiSCf 152 40 111 1 0.00 0.00 0.00 0.50 14.00 34.00 44.00 8.75 13.52 Controls 7 580 124 452 4 0.00 0.00 ~ 0.00 2.50 13.00 27.00 43.00 8.20 10.91 AII 732 164 563 5 0.00 0.00 i 0.00 2.00 13.00 28.00 44.00 8.34 11.56 Wom€n Cife3 531 330 179 22 0.00 0.00 0.00 7.00 17.00 28.50 52.00 10.63 11.77 COnKOkf 1076 694 355 27 0.00~ 0.00 0.00~ 6.50 17.00 25.00E 50.00 9.82 10.69 All 1607 1024 534 49 0.00 0.00 0.00 7.00 17.00 27.00 52.00 10.08 11.05 AN Ca1e3 683 370 290 23 0.00 0.00 0.00 6.00 17.00 29.00 52.00 10.43 11.97 { ConVolf 1658 816 807 31 0.00~ 0.00 0.00 6.00 16.00 26.00 50.00 9.58 10.73 All 2330 1188 1097 54 0.00 0.00 0.00 6.00 16.50 27.00 52.00 9.84 11.13 SQUAMOUS CELL CARCINOMA MCn CSSCf 28 4 24 0 0.00 0.00 0.00 0.00 4.00 8.00 8.00 ! 2.00 [ 4.00 COn1fNf 880 124 452 ~ 4 0.00 0.00 0.00 1 2.50 13.00 27.00 43.00j 8.20 10.91 AD 608 128 476 I 4 0.00 0.00 0.00 2.00 13.00 27.00 43.00 'E 8.01 10.81 WOn1€n MQf 97 62 31 4 0.00 0.00 0.00 10.00 20.00 34.00 45.00 12.63 13.20 Controls 1076 694 355 27 0.00 0.00 0.00 6.50 17.00 25.00 50.00 ~ 9.82 10.69 Afl 1173 756 386 31 0.00 0.00 0.00 7.00 17.00 26.00 50.001 10.05 10.93 A11 CaStf 125 66 $51E 4 0.00 0.00 0.00 10.00 19.00 34.00 45.00 11.99 13.07 Controls 1656 818 807! 31 0.00 0.00 0.00 6.00 16.00 26.00 50.00 9.58I 10.73 Afl 1781 884 862I 35 0.00 0.00 0.00 6.00~ 16.00 26.00 50.00 9.76I 10.93 CARCINOMA Mcn CBSCf 14 2 12 0 0.00 0.00 0.00 0.00 0.00 0.00I 0.00 0.00 0.001 Controls 580 124 452 4 0.00 0.00 0.00 2.50~ 13.00 27.00! 43.00 8.20 1 0.911 AN 594 126 464 41 0.00 0.00 0.00 2.00~ 13.00 27.00M 43.00 8.07 10.88 Wot1on C8:C3 37 39 25 3 0.00 0.00 1.00 6.00I 12.00 24.00 47.00 9.00 10.37 Controls 1076 694 355 27 0.00 0.00 0.00 6.501 17.00 25.00 50.00 9.82 10.69 A11 1143 733 380 30 0.00 0.00 0.00 ~ 6.00f 16.00 25.00 50.00 9.7810.66 All CIDSCf 81 41 37 3 0.00 0.00 0.00 5.00 ',2.00 24.00 47.00 10.30 8.56 Controls 1656 818 807 31 0.00 0.00 0.00 6.00 16.00. 26.00 50.00 ~ 9.58 10.731, All 1737i 859 844 34 0.00 0.00 0.00 6.00 16.00 25.00 50.00 9.53 10.71 MM1 COf€f CotllrolS All 80 580 660 23 124 147 561 1 452i 4 508 5 0.00 0.00 0.00 0.00 0.00 0.001 0.00 0.001 0.00 0.00 2.50 2.00 19.00 13.00~ 15.00 39.00 27.00 28.00 44.00 11.13 43.00 8.20 44.00 8.66 15.79 ~ 10.91 1 11.79 WOrri€n C85€3 281 i75 951 t1 0.00 0.00 0.001 7.00 16.00 28.00 41.00 10.11 11.21 Controls 1076 694 35511 27 0.00 0.00 0.00f! 6.50 17.00 f 25.00 50.00 9.82 I 10.69 I AH 13571 869 450 38 0.00 0.00 0.001 7.00 16.00 26.00 50.00 9.88 10.79 All Cases 361 198 151 12 0.00 0.00 0.00 6.001 17.00 30.00 44.00 10.23 11.78 E Controls ~ 1656 818 807 31 0.00 0.00 0.00 6.00f 16.00 26.00 50.001 9.58 10.73 All 2017 1016 958 43 0.00 0.00 0.00 6.00f 18.00 27.00 50.00 9.70 10.94 OTHER M€n CLSQf 30 Controls ~ 580 All i 610 11 124 135 19 452 471 0 4 4 0.00 i~.00 0.00 0.00 0.001 0.00 0.00 3.00 0.00 2.50 0.00 3.00~ 15.00 13.00 13.00 22.00 27.00 27.00 31.00 43.00 43.00 7.821 10.57 8.20~ 90.91 8.17~ 10.85 WOniGn (..'9SC3 86 54 28 4 0.00 0.00 0.00 7.00 19.00 30.00 52.00 11.22 12.74 Conlrolf 1076 694 355 27 0.00 0.00 0.00 6.50 17.00 25.00 50.00 9.82 10.69 All 1162 748 383 31 0.00 0.00 0.00 7.00 17.00 26.00 52.00 9.92 10.84 A!I C86C3 116 65 47 4 0.00 0.00 0.001 6.00 17.00 30.00 52.00 10.65 12.39 ConlrolS 1656 818~ 807 31 0.00 0.00 0.00 6.00 16.00 26.00 50.00 9.58 10.73 AIl 1772 883 854 35 0.00 0.00 0.00 6.00 16.00 26.001 52.00 9.65 10.86 >75% OF LIFESPAN IN RURAL AREA OR INTERMEDIATE CITIES Md1 CiSCf 76 10 66 0 0.00 0.00 0.00 1.50 29.00 37.50 44.00 11.00 16.82 Controls 225 38 185 2 0.00 0.00 0.00 '.00 19.00 28.00 41.00 9.45 11.80 AH 301 48i 251~ 2 0.00 0.00 0.0U 3.00 19.50{ 29.001 44.001 9.77{ 12.81 WOnICn C95C3 237 151 83 3 0.00 0.00 0.00 7.00 16.00 28.00 47.00 10.38 11.82 Controls 462 283 172 7 0.00 0.00 0.00 8.00 18.00 27.00 50.00 10.41 11.03~ All 699 434 255 10 0.00 0.00 0.00 7.50 17.00 27.00 50.00 10.40 11.30 AIl C95Cf 313 161 149 3 0.00 0.00 0.00 6.00 16.00 29.00 47.00 10.42 12.12 Conlrrolf 687 321 357 9 0.00 0.00I 0.00 7.00 18.00 27.00 50.00 10.301 11,11 All 1000 482 506 12 0.00 0.001 0.00 7.00 17.00 27.00 50.00 10.34 51.44 >75% OF LIFESPAN IN URBAN AREA Mcn Cases 48 21 26 1 0.00 0.00 0.00 3.00 19.00 37.00 41.00 10.86 13.94 Controls 257 62 193 2 0.00 0.00 0.00 0.00 12.00 21.00 37.00 6.86 9.87 A11 305 831 219 3 0.00 0.00 0.00 0.00 13.00 26.00 41.00 7.87 11.09 WOn1€n CdSM 196 123 60 13 0.00 0.00 2.00 10.00 21.00 30.00 52.00 12.94 12.37 Controls 454~ 322 120 12 0.00 0.00 0.00 6.50 16.00I 25.00 45.00 9.61 10.36 AJI 850~ 445 180 25 0.00 0.00 0.00 8.00 17.00! 26.00 52.00 10.53 11.04 AN Ce;€3 244 144 86 14 0.00 0.00 ':.50 10.00 20.00 30.00 52.00 12.64 12.58 Contf013 711 384 313 14 0.00~ 0.001 0.00 6.00 15.001 25.001 45.00 9.17 10.321 All 955 528 399 28 0.00 0.00 0.00 7.00 17.001 26.00 52.00 10.11 11.08 •~~~ ;5g3454 T.... bt..~ -

D - S3UD Spouse and other cohabitants, Duration (years) (non overtapping) aLLcecctiSrts L.vel of.xposure ~ Cases Controis) OR(1) 95%CI HE., 631.10<34 509 1291 1.00 34<S3U0<•42 68 ~ F 123 1.36 ( 0.97- 1.92) 42<s3u0 J 46 90 1.14 ( 0.76- 1.72) fxc1uded/Trendj 27! 381 0.11 ALL CENTERS NfITH EDUCA110NAL LEVEL AND TYPE OF RESIDENCE OR(2) 95% CI OR(3 95% CI { OR 4 95% CI ( OR(5 95% CI 1.00 1.00 1•DO 1.00 1.29 ( 0.90- 1.85) 1.29 ( 0.87- 1.93) 1.41 ( 1.00- 1.99)i 1.38 ( 0.92- 2.07) 1.15 j 0.75- 1.75) 0.97 { 0.60- 1.56) 1.25 ( 0.82- 1.89)I 0.99 r- 0.63• 1•57) 0.11 0.14 ~ 0.10 0.12 1.00 1.00 1.00 ) 1.00 1.30 !, 0.87- 1.94)~ 1.29 ( 0.87- 1.93)~1.34 ( 0.89- 2.00)1 1.51 ( 0.97- 2.34) 1.01 ( 0.63- 1.63) 0.97 ( 0.60- 1.56) 1.08 ( 0.67- 1.76)I 0.96 ( 0.57- 1.61) aExcludod/Trsndf 68 ALL CENTERS YYfTH DIETARY DATA HE. S3u0<34 34<S31.10<42 42<33UD 0.48 ~ 0.52 ( I 394 857 1.00 1.00 1.00 1.00 t.oo 50 81 1.39 ( 0.93- 2.08) 1.43 ( 0.95• 2.17) 1.54 ( 0.98• 2.40) 1.43 ( 0.95- 2.14)~ 1.38 ( 0.92- 2•07)~ 36 71 1.01 ( 0.64- 1.59) 1.05 ( 0.66- 1.66) 0.92 ( 0.55• 1•55) 1.09 ( 0.68- 1.73) 0.99 ( 0.63- 1.57 ') Ercluded/Trond 29 47 0.24 0.24 0.28 0.23 F 0.27 ~ FRANCE HE., S31.10<.34 67 1125 1.00 1.00 1.00 ~ 1.00 1.00 34<S3UD<42 3 14 0.43 ( 0.11- 1.61) 0.27 ( 0.06- 1.31) 0.37 ( 0.07• 2.01) 0.44 ( 0.12• 1.64) 0.42 ( 0.11- 1.59) 42<S3UD 7 11 1.26 ( 0.43- 3.67) 1.11 ( 0.34- 3.63) 0.53 ( 0.08- 3.43) 1.44 ( 0.48- 4.3