Philip Morris
Researchers Try to Separate Smoking Fact From Fiction
Fields
- Author
- Stolberg, S.
- Area
- WORLDWIDE REG AFFAIRS/LIBRARY
- Type
- NEWS, NEWS ARTICLE
- Attachment
- 2048252199/2048252525
- 2048252502/2048252505
- Named Organization
- Inst of Toxicology + Environmental Healt
- Journal Inhalation Toxicology
- RJR, R.J.Reynolds
- Uc Davis
- Uc San Francisco
- Univ of Ky
- US Centers for Disease Control + Prevent
- Epa, Environmental Protection Agency
- Journal Inhalation Toxicology
- Named Person
- Coggins, C.
- Glantz, S.
- Gori, G.B.
- Joad, J.
- Pinkerton, K.
- Surgeongeneral
- Witschi, P.
- Glantz, S.
- Document File
- 2048252198/2048252525/Bero Barnes (Ciar)
- Request
- Stmn/R1-048
- Master ID
- 2048252379/2524
Related Documents:- 2048252379 Requested Papers
- 2048252380
- 2048252381-2386 Evaluating the Quality of Articles Published in Journal Supplements Compared with the Quality of Those Published in the Parent Journal
- 2048252387 Preventing Alcohol and Substance Abuse in Minority Youth Recent Results From Asap Training and Demonstration Programs. Prevention Works: Trends in Drug Abuse Education 760000 - 900000. Long Term Prevention of Tobacco Use Among Junior High School Students Through Classroom and Telephone Interventions. Misuse of the Scientific Literature by the Tobacco Industry.
- 2048252388-2391 Appendix Coding Definitions for Article Content
- 2048252392-2402 Tobacco Industry Response to A Risk Assessment of Environmental Tobacco Smoke
- 2048252403 Quit and Win Wales: An Evaluation of the 900000 Pilot Content
- 2048252404-2406 Inappropriate and Appropriate Selection of 'peers' in Grant Review. Public Bias and Public Policy
- 2048252407-2414 Sponsored Symposia on Environmental Tobacco Smoke
- 2048252415-2418 Publication Bias and Public Health Policy on Environmental Tobacco Smoke
- 2048252419
- 2048252420-2421 Taking Money From the Devil
- 2048252422
- 2048252423-2429 the Publication of Sponsored Symposiums in Medical Journals
- 2048252430-2431 Tobacco Industry Funding of Biomedical Research
- 2048252432
- 2048252433-2438 Ethical Issues Relating to the Conduct and Interpretation of Epidemiologic Research in Private Industry
- 2048252439
- 2048252440-2445 Independent Investigators and for-Profit Companies Guidelines for Biomedical Scientists Considering Funding by Industry
- 2048252446
- 2048252447-2450 Source of Funding and Outcome of Clinical Trials
- 2048252451
- 2048252452-2456 Sounding Board Avoiding Bias in the Conduct and Reporting of Cost-Effectiveness Research Sponsored by Pharmaceutical Companies
- 2048252457
- 2048252458-2465 Uniform Requirements for Manuscripts Submitted to Biomedical Journals
- 2048252466
- 2048252467 Editorial Conflict of Interest Policy
- 2048252468
- 2048252469-2471 New Requirements for Authors: Signed Statements of Authorship Responsibility and Financial Disclosure
- 2048252472
- 2048252473-2475 Commentary Conflict of Interest and Scientific Publicati
- 2048252476
- 2048252477-2479 Dealing with Conflicts of Interest
- 2048252480
- 2048252481-2482 New 'information for Authors' - and Readers
- 2048252483-2491 A Study of Manufacturer - Supported Trials of Nonsteroidal Anti-Inflammatory Drugs in the Treatment of Arthritis Reporting and Documentation of Efficacy and Toxicity
- 2048252492
- 2048252493-2497 Sounding Board Physicians' Conflicts of Interest the Limitations of Disclosure
- 2048252498
- 2048252499-2501 Commentary Conflict of Interest the New Mccarthyism in Science
- 2048252502
- 2048252506-2507
- 2048252508-2513 Influence of Design Characteristics on the Outcome of Retrospective Cohort Studies
- 2048252514
- 2048252515-2519 Conflict of Interest Dilemmas in Biomedical Research
- 2048252520
- 2048252521-2524 When Researchers Accept Funding From the Tobacco Industry, Do Ethics Go Up in Smoke? the Research Game.
- Litigation
- Stmn/Produced
- Author (Organization)
- Los Angeles Times
- Site
- N403
- Date Loaded
- 05 Jun 1998
- Brand
- 1r4f
- Camel
- Marlboro
- Virginia Slims
- Camel
- UCSF Legacy ID
- rfq92e00
Document Images
=Xc1L 0cC-
ro years of
id stalled
.d be "dif-
'ould ulti -
ins taking
+n fate.
ugh other
, recalling
i the 17th
= from the
:Ow from
ULE, Aid
0
tration aia of tAe t;hinese system.
The key to Beijing's strategy was
to divert attention from human
rights issues by using the blinding
lights of China's booming economy
and huge potential market. By
doing this, Chinese officials said,
they successfully broadened the
- terms of the debate inside the
United States. As a result, the
Clinton Administration fobna ftself
fighting back on many fronts, often
against aome of its own - mo$t
happy to go to bat for the Chinese
with their powerful public rela-
tions machines.
"My feeling is that a few huge
companies had more at stake than
in the past." said Anne Stevenson-
Yang, Beijing director of the U.S.
China Business Council. American
executives, for example; lobbied.
hard^"'Mr a last-minute meeting
between Clinton and Chinese Vice
. lteam see CHIlVA, Ait
RearchersTrytoSeparat~
esSm~l&gF~d Fr~m Fi~tioO
stndW. But ft.re is 'a co11Wofi-af,p6Ii fics arrdv' _. ,-
r Health: Effects of sec~andhand exposure are,,beki.ng
4
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tute of Taidoology a~d E'~nvl~n-
,in "~V+tnfe cauegr tmiv ~ kolcm debate'over the*~~tingra ai beieorid".
: mor* iike a bani tthan a hiahtech
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unf veraity labotgtory. Inaidt, a
rare and cuiioua . contraptfon la - C'I,EA.RING'1HE AIR. '
engaged irt a habit tt,at the surge6ii" ~ .
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A~ 5A7URDAY, MAY 21, 1444 ~A
L.OS AtvCG1,F5 TTMES
TOBACCO: Scientists Researching Effects of Secondhand Smoke
C.atla.40111 h..r Al
womb! Don .econdhand anake
11aduct arhtn,gea In the naul pas-
eapCwayr~ liut load io ao! L
'ihPre . pn~ciae doae-tu lack of a
Drtter t.ertm-at which It becomee
dangerot~! 11 w, where doea the
lhietllo~d ile?
li a ltme when 'Seeondhsnd
3taoke Mblls'° tdllboardt, ve pop-
pirS up acrosa Califomla, and ahe
goverttrtmt has clauitled secwd-
hanel smolce a a human tarctno-
pn, nonumokere worry that the
aN,ghteat whitl of ,rnoke could
wreak Iluvoc on thek lunds and
tuarta. L'igtrette eompanin are
waginir a oounterattack, tnsisting
lhil It l1 litlle more than a nui-
aancc.
] 'flse truth, whkh Independent
) a4nUata say Is aomewhere In
j between, may emerge from the
r amoyinj mulchine.
clenlitic trutha about sec-
ondhend smoke are not euy
to cume by. Sludlea ue dilh-
eutl and ezpensive to con-
J'
r
7
]
duct, snd funding la limited. Nore
over, ethical consideratlons
prevent reseuchen from subject-
tns humans to cldarettc smoke, at
leaat not lor daya on end. Nor can
they uk peayfe to anoke 1or the
sake of science.
Henee the busy Davir tnwking
machine.
f'ivt days a week, aiu hours a
day, ttx machine ia at work, blow-
a inQ smoke at guinea pip and
j llarroters, whose body parts will
lattr be dlssected in an e!(ort to
idetttily biological reectionr t,hnl
may be rimitu In humana. The
+deviae--ane ol /uat two larp-acaie
j amokirtd nuschlnme In the nation
outsida ot those owned by tobacco
~ cqnpaniea-smokee inoso precbe.
t,y than any persan ever could, and
therein lia Ila value.
Thcre an tq Itwlbam Cameim
a Virainls 6limr here. Rather, the
'~ awokinj auchine'e hrand of ctwke
. li one hw 'eopi.e have head
a/-lhe lll~lr. ''llae 1ow-4gr and
~ -~~cptint Ceseirch cljarettt~m eiaClt
awufeceured itutn the aame to-
~'+baach bierld, ut pmduced by the
: Oniverrity of Kentucky. They
, were rolled tn 19M and kcpt lm a
,`lcep freezc unbf brinw AhvTx,.r1 tn
UC Davis rasesrt?ters Pater INttschl, left, and Kent Plnkerton watch their precislon smokina
mechine, wfkb pvRa e4nlttq #m. *yf Jt veeek, ut hours a day
snwke Fn the home-an Ita prlroa.
ry vietima.
Amonl the Davia tindinas. Toud-
eologisl Pete: Witechl has .hown
that pregtant rata o4watd to eec-
oasdhand an>ake Pve birth to pupe
ihat are4hed 9% lema t11ut thcn
born to Wh:es nia=tlot a d?amattc
neQ,x.tion, but one that e3pru a>\y
is ai1ntficarlt. De. Jesse Jaad, a
pedtrarician, htu desnatstrated that
newborn rats expooed to aecottd
hans snookt 1s the w=b and aNer
birth terl poldUve 1oa ssthnna. Pin
kerion haa found th.at the tunp of
newborn ntr develop mote slowly
that ara beyond the capactty of the
animals to clesy."
Witachi aa,ya the daaea rat be
enanipulated-and must be-i1 aci-
entlsty an to karn at what kveis
.ecandhand sntoke becomes dan-
garacue.
T //''''~~''''~~ he animalr in the Davis
~egerimenta aro genoraliy
e>poaed at I,OOD micro-
rruma of mnoke particlef
per tuMc metee of air-levela that
the researchan aay an high, but
can be found In typbcat smoking
environmenu. such as ban. How-
wv.r .n.... wAinv
per cubic mcter. i{la vat studies
employed e"urer of 100 micro-
drama, 1.i)04 microgsams and
10,000 micro,glartve-and found no
tllects even at the hiahest dose. ?re
aaid.
a
On such mtnutiae hang the an-
swen to cruciai aueetions about
secondhand smoke'a health eftecla.
Accordittg to the U.S. Centarf toT
Disease Control and Preventi,on, as
well u heaith advocacy rrouya,
51000 people dae each year from
expaeure to aecondhand emoke,
se.condhsnd iawke a arot® A 1hu-
men cuclnogdn-a dlrlAos4lna
that pvu il In t1x an fr oatopeyai
radon aod a+bertoa. Dal iobaaso
Indurtry at8r3ab w.y aJtr QA'a
reatarch I. fLwrA ti.aauw 11011011110
overesttmate the ataotml d waoin
they have bem eaqxwd 0% at ib
about lfxir smoiir,f baDiL
7u aninx) tvaeareh sq aWk
this dtfiate by dto.kar MAat tli-
derrtio3oty canno4 Mr4Ctw(y lM
teoondhan4 arnwka imaala itsbtr
artee
oc, and esactly haw tpndt aa
la dangerass.
Rrperta tayy tt is ml aait to
urt1, what t,moken Uthair I
tln61r0 ae °oHinitreltn f8otia.'
1Vtsel oottwt oQ the burr.ditlf and o
Ihs ci,garatte Ia aideets".
1®oiu." Becoodhus0 eoaata-aiu
(ttfollp aa anvtfOCtDeotai tcbac01
aooke-r n.ae up mo.uy .t r
d.ijvaa smotr4lot 030 bdtidW
'Dat t>ke rrnosa eetuias.
8idaatram smole h . cotsyiea
bhoe d ttarr tAtn lM afai.t
brwaldaRJM, wMais. alodin
tloe, eidai Ntid atwnic, fa 1Yr aY.
fd .Y en atuiiw ier~ett aaw a~rad
atti ar.poeate. .ome toetOattM.
w.,. Ni.rN U 1hw nnlrHr ne OW

: were roiied in 1983 and keyt in a
~&eep fneese until being ahipped to
a pavL, where they are omditloned
/ut up to /19 Tioun at 7096 humidity
/efore beina enwked.
~' Every 10 minutea, a eteet ptruon
jrete arother 1 NvInto a revodvfnti
w tyUnder. A amaU aMal aoi}, tlu sort
: m.md to Deat in ordinary bION-Qry-
11.r,(1LAfita the eiSarette with a uny
red Stavr. Aa ah" be& tn erneryle,
Iwo othen 1re in varlotr ttm.gea of
betni uawked. 'Ttte w'Fwie mecha-
~ Tobn Is enrsaeA in e plexigtam boa
* elut is yellow with amDko readdue.
: Tarvtt;ll a aerla of plpea. the bcu ii
oannected to thamDen where the
' antlrula ese kept.
. With every puff, the cytlnder
~ alicke anotTxr revolutian and a ttd
~ tlght 1luhea, Each clgarette-tltirre
- aem neve+ aaaes t}un thiee burming
: at any ttme-la anoked in yree5aely
~ U aroe fattbn, one ywff a ntlnut e,
, eseh puff IuUnta. Iwo aeaortde, e4ht
- Vjffe in aU.'1b rrcate each putf, a
: raw= draws in 36 mlttikten ol
a17+-n0171ore, no Le1.
'1°nere lR, PinYerton aaye, in tm
portant nxion for ail tAis pted®ion.
Sot1apoken and lanky, the eci-
enUat Ir a maater of understate
ttel'»~ nerer toins out on a lUab. "lf
Ks in going tn tuAeratand the
tlwchanttms lby a+htch.eoandhand
mwke Wurea peopiH: he aay.,
~ "we need to have weU-ooneralied
conditbru."
l]
'14se DavU atudiee have been
-vwder way for three yem-a short
~ apan In xienoe. when raearch
; aflen Lsu (or dee.da. The uni-
_yer.ttY_ t+4~n4~ ~3S_P!4~uivly _"You can manipulate the aperi-
.kntesteted in the eilecte oi aeoonE menta any i+ayyau ~¢rt1 ueAcome
'fitand orroke an youn0 ebUdron, up w1th some rerulte,," Cori eom-
stt4dieaahow [nfantaandtoddlerl- plcined of the reweareb at Davb
'.rb.o may rufler from EronchltU, usd otber animal atudlea, "You oan
aattinu usd other respitatary dtr- choae a etraln }o[ aMmal; ilut Is
easee when eayokd to .ernndtsand eueceptlbk. and you can use doee.
ar[wn tuay Iuurlu c71a1 tnhC lW7gD ol
newborn rats develop ttwrr slowly
when ecpoaed to secondhand
atwke.
Ae part of the experlmenta, Joad
t.lnvesttpting how ner.e Qbet1 In
the lun®a of gulnea pila are
harmed by eaporura to aeowtidhand
anokeq the dan1.p pravenU the
tumgs from fendlry off otherpollu-
tant,. Wft.chi b trylrt[g to deter-
mine whether a partlcularly atrong
earci"en calTed NNK produca
lung tumot. In banvt.era eipo.ad in
.eoondhand enwke. as 1M1 does In
anlatal. tfiat Lreatleddlnnet amate.
Few .ncb a4udlea have bcen
done before. "Thla !t very be8tn-
ning Kufl," Joad sald, addint. "'fhe
kind of tplity tAat we are iolrvj to
da absolutely could never be dm
on chlldtm"
'tbbaaco Induatry critics aontetM
Uaft~xl~i ~ ia~t~ for
e.lgarette tnakee A.l. Reynoid., My.
Ire hai dAne hb own aniasal re.eractt
an rats tutd Wtid no broia0otl
chtnWeri Irt tDe haut, fungt a'
rewinetvy 1yate+n'11he cnA1 dam-
ade doswnented In the tdtjo-
.+hicb nppeared lat Yea,r In tf]e
1aum.l LshalaUon Z'arjoataa-ac-
murad In the ttp of the rsW twaee,
Oautn. atld, .rd .ru "ootnqsletd,y
revadbk" when t}xy were m
langrr aWo.ed to the anoke.
Totneoo 1nduwtry ootunAtant Cio
Batts Gari, alao a laodcolodid, ctlta
the Davis awdlee brekvant Hu-
maro. Cori tuguea, have the `Yn-
triniie capaclty" to clcat tbeir
bodSea of lop-level pollutants. In-
cludinl a.caVAhand aaoka
envlrwtmenta, such aa bs>m. How-
aver, some atudlea-includlnB
Wltachl'a NNH raearcn-emptoy
IevelL a high as 4,flOD mlcrot(rama,
.oncentratiotu that he .ckmowl-
eddea arre much higher than tZioae
fwtnd In the real wvrld.
7Tte.a oonoentralloni ate a ma.t-
teT of pe,mt dispute. Cbggtna, the
ReYnoldt toilcologtet, rnalntafns
tGat realwarld concentr.Uona av-
enaW only 35 mlcropami per cu-
bic meter In emoktny hames. In
barE, be aaye, comenlritMotn would
nn o* n hil'b as l0o mtcroqranu
6.7,000 people dle eaeh year trom
enwwre to aeomtdhand tmoiee.
This figure ts ba.ed on eg3damloTo-
my rtudler, which entaiziepaltcrrn
of Ulne.a but do not prova cause
znd efieci
The studies irrepiicale tteoaid-
bond .mo.ke in lun,g canctr and
otJter canoen, he.zt di.ea.e, tad-
den Infant dwtD qndmt. Mrn-
t:hlUa, pneumonSa and atLma. s-
Decially In childmx
The U.& btvhwrnental Proeo-
lion Agency. relying on the lung
cancer vWernlology, 4tt declared
-JENNIFEa VALUE
DMD Ef ALY QUALITY!
T.....«,.y ,ww u1Ht:7l6iSKEllJ'e
la atnaG~ORa.
t~pertr tay It b nol wh to
auvnx tLat pud.. eaw" at-
f+c1a people In the ama wRy as
activc mtokln% Thh Ie taa pro
teasonu Those exposed t c nooPd-
6and amke Iet a araalla do.a-
inBalina about 1% d the Undria
ih.tt maokmn alsacb. At tbe wme
llme, howe, er. .eoondtsrb .amke
in ntuth dirtter, pariU bec:nae It
tber twt to throq/h eissraite
fUtev, aald Stanton Olants, a lTC-
Dan FY.nciaoo raicuc2mr.
ln ME budnam d tab.aoa re-
..a., ICrx ana tr.entc. Ln tl
It L an elwive taqtty aome d
ulo evaporate, aome oond
aome attach to the tfalttj a
lunWwhen lnTuled wdlk oUti
net_
T he EPA Me faunck thr
known human oatCln
and rdne prvMDle o0
rer1A ars eaUttad at h
lerela In ddettr~un taiw~e u
mainatream snoke. 00m toa
ements-Includhu carbon tv
Ide. tmmonia, nk5otine anb
tone-are more oaKentnt.
n...... raisooa
you the Sealy Comfort
Only Jennifer givesft
0 P......4^.w.._.....Aft..a t.. _ Alb Aft!_L..J
