Tobacco Documents Online

NEIL L. BENOWITZ, M.D. Address: Topic: Chairman ETS Exposure Department of Clinical Pharmacology Use of cotinine as specific University of California at San Francisco marker of ETS Building 30, Fifth Floor 1001 Potrero Avenue San Francisco, CA 941110 CURRICULUM VITAE N.L. Benowitz, Curriculum Vitae, 1989 [] N.L. Benowitz, Curriculum Vitae, October 1993 [OSHA Expert Statements, 11313; OSHA Hearing Exhibit 291 EPA SUBMISSIONS/TESTIMONY G. Amrein, N.L. Benowitz, D. Brody, B.V. Marin, E.J. Perezstable, "Response to Reviewers Comments (on EPA Risk Assessment)", 1990 [ Request] N.L. Benowitz, Letter, re: "Indoor Air Quality and Total Human Exposure Committee on Environmental Tobacco Smoke Review", July 1992 [ Request] S. Bayard, V.G. Laties, N.L. Benowitz, H. Rockette, W.J. Blot, D. Ryan, K. Brown, J.M. Samet, D. Burns, J.A.J. Stolwijk, J. Daisey, T. Thorslund, D. Eatough, J.J. Wesolowski, S.K. Hammond, J.E. Woods, G. Kabat, "Testimony: Indoor Air Quality and Total Human Exposure Committee, U.S. Environmental Protection Agency, December 5, 1990, Environmental Tobacco Smoke Review" December 1990 [State of Maryland]; EPA Administrative Record] N.L. Benowitz, Letter re: Comments on Risk Assessment [ Request]

OSHA SUBMISSIONS/TESTIMONY N.L. Benowitz, "Statement to OSHA: Cotinine is a Valid Marker of Environmental Tobacco Smoke Exposure", August 1994 [OSHA Expert Witness Submissions, 113131 N.L. Benowitz, "Testimony at OSHA Hearing on Indoor Air Quality Proposed Rule", September 1994 [OSHA Hearing Transcript] N.L. Benowitz, "Examination of R.J. Reynolds by NL Benowitz at OSHA Hearing on Indoor Air Quality Proposed Rule", January 1995 [OSHA Hearing Transcript] N.L. Benowitz, [OSHA Post-Hearing Comment, 3481 N.L. Benowitz, [OSHA Post-Hearing Comment, 479] PUBLICATIONS N.L. Benowitz, C. Denaro, P. Jacob, R. Jenkins, "Stable Isotope Studies of Nicotine Kinetics and Bioavailability" [OSHA Public Comments, 9-47553 (RJR)] N.L. Benowitz, P. Jacob, "Nicotine and Cotinine Elimination Pharmacokinetics iin Smokers and Nonsmokers" [OSHA Public Comments, 9-47553 (RJR)] V. Baerweiss, N.L. Benowitz, E.R. Gritz, M.E. Jarvik, H. Vanvunakis, "Plasma Nicotine and Cotinine Concentrations in Habitual Smokeless Tobacco Users", Clinical Pharmacology Therapy, August 1981 [ Request] N.L. Benowitz, P. Jacob, R.T. Jones, J. Rosenberg, "Interindividual Variability in the Metabolism and Cardiovascular Effects of Nicotine in Man", Journal of Pharmacology and Experimental Theraoeutics, 1982 [OSHA relied on in development of Proposed IAQ Rule, Exh. 8 ] N.L. Benowitz, P. Jacob, R.T. Jones, F. Kuyt, A.L. Osman, "Cotinine Disposition and Effects (Study of Cotinine Disposition Kinetics in 28 Healthy Habitual Cigarette Smokers)", Clinical Pharmacology Therapy, 1983 [OSHA relied on in development of Proposed IAQ Rule, Exh. 8_] N.L. Benowitz, C.E. Bickler, B. Cady, D. Follart, "Passive Absorption of Nicotine in Airline Flight Attendants / Cost of Smoking", New England Journal of Medicine, May 5, 1993 [OSHA, Request for Information; State of Washington, 93-2091 -2- I

N.L. Benowitz, P. Jacob, "Daily Intake of Nicotine During Cigarette Smoking", Clinical Pharmacology Therapv, April 1994 [OSHA relied on in development of Proposed IAQ Rule, Exh. 8-23] N.L. Benowitz, P. Jacob, "Nicotine and Carbon Monoxide Intake from High-and Low- Yield Cigarettes", Clinical Pharmacology Therapv, August 1984 [OSHA relied on in development of Proposed IAQ Rule, Exh. 8-24] N.L. Benowitz, S.K. Hammond, N.Y. Kado, S.A. McCurdy, "Measurement of Personal Exposure to Mutagens in Environmental Tobacco Smoke" Indoor Air '87; Proceeding of the 4th International Conference on Indoor Air Quality and Climate, August 1987 [OSHA Public Comment, 9-47553 (RJR); OSHA relied on in the development of Proposed IAQ Rule, Exh. 8-97, 8-266, 8-2151 N.L. Benowitz, J.D. Dubbin, R.B. Haynes, M.G. Myers, M.J. Sole, "Cardiovascular Effects of Smoking in Patients With Ischemic Heart Disease" 1988 [OSHA Public Comment, 9-47553] N.L. Benowitz, P. Jacobs, "Determination of Cotinine in Biological Fluids of Non- Smokers By Capillary Column Gas Chromatography", May 1988 [ Request] N.L. Benowitz, C. Feyerabend, MJ Jarvis, MAH Russel, "Elimination of Cotinine from Body Fluids: Implications for Noninvasive Measurement of Tobacco Smoke Exposure" American Journal of Public Health Briefs, June 1988 [OSHA Public Comment, 9- 47553 (RJR), OSHA Exhibit 8-167] N.L. Benowitz, P. Jacob, J. Johnson, M.A. Wall, "Cotinine in the Serum Saliva and Urine of Nonsmokers Passive Smokers and Active Smokers" American Journal of Public Health, June 1988 [OSHA Public Comment, 9-47700] N.L. Benowitz, D.J. Brody, G. Marin, E.J. Perezstable, B. Vanossmarin, "Deception in Self-Reported Cigarette Consumption Among Mexican-Americans", December 1988 [ Request] N.L. Benowitz, A.E. Camilli, M.D. Karol, M.D. Katz, S.K. Matsunga, P.M. Plezia, "Effects of Passive Smoking on Theophylline Clearance", October 1989 [ Request] N.L. Benowitz, D.J. Brody, G. Marin, E.J. Perezstable, "Apparent Underreporting of Cigarette Consumption Among Mexican American Smokers", 1990 [ Request] N.L. Benowitz, "Nicotine and Coronary Heart Disease", Brief Reviews - Trends Cardiovascular Medicine, 1991 [OSHA, Exhibit 8-25] -3-

N.L. Benowitz, "Nicotine and Cardiovascular Disease", 1991 [OSHA Public Comments, 9-47553 (RJR)] N.L. Benowitz, "Report of Scientific Advisory Board; Environmental Tobacco Smoke Review" Section 5.1.2 Spousal Smoking, January 1991 [EPA Administrative Record; Request) N.L. Benowitz, C Denaro, P Jacob, R Jenkins, "Stable Isotope Studies of Nicotine Kinetics and Bioavailability", (Study of Disposition Kinetics of Nicotine in Smokers), Clinical Pharmocoloov Therapy, March 1991 [OSHA, Exhibit 8-28] N.L. Benowitz, BV Marin, G Marin, E Perezstable, "Misclassification of Smoking Status by Self-Reported Cigarette Consumption", July 1991 1 Request, EPA Administrative Record, OSHA Public Comment, 9-476031 Tobacco Use in California; A Focus on Preventing Uptake in Adolescents; Executive Summary, 1992 [OSHA Additional Literature, 11-86] N.L. Benowitz, P. Jacob, "Nicotine and Cotinine Elimination Pharmacokinetics in Smokers and NonSmokers" (Study Concerning Metabolism of Nicotine and Cotinine), Clinical Pharmacology Therapy, March 1993 [OSHA, Exhibit 8, 8-24, 8-29] N.L. Benowitz, I. Fong, S. Gupta, P. Jacob, "Nicotine Metabolic Profile in Man: Comparison of Cigarette Smoking and Transdermal Nicotine", September 1993 [OSHA, Exhibit 9-465531 N. Aintablian, C.J. Chamberlin, M.H. Sawyer, M.R. Wallace, Ywu, "Detection of Varicella - Zoster Virus DNA in Air Samples from Hospital Rooms", Journal of Infectious Diseases, October 1994 [OSHA Additional Data, 11-1841 N.L. Benowitz, B. Chattopadhyay, J.D. Debethizy, P. Jacob, G.A. Kyerematen, M.L. Morgan, E.S. Vesell, "Nicotine Metabolism in Cigarette Smokers and Nonsmokers Clinical Pharmacology & Therapeutics", October 1994 [OSHA Public Comment] N.L. Benowitz, "Cardiac Toxicology Hazardous Materials Toxicology Clinical Principles of Environmental Health - Chapter 15", February 1994 [OSHA H-030, ASH Petition, 13-1661