Philip Morris
A Study of the Relationship Between P53 Mutation and Smoking in Non-Small Cell Lung Cancer
Fields
- Author
- Bi, X.J.
- Li, J.H.
- Peng, Z.H.
- Li, J.H.
- Type
- REPT, REPORT, OTHER
- Document File
- 2029049064/2029049554/International Symposium on
- Life-Style Factors and Human Lung Cancer
- Site
- I10
- Request
- Stmn/R2-038
- Author (Organization)
- 1st Military Medical Univ Guangzhou
- Nan Fang Hospital
- Master ID
- 2029049067/9553
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- Litigation
- Stmn/Produced
- Area
- WALK,RUEDIGER-ALEX/INBIFO OFFICE
- Date Loaded
- 05 Jun 1998
- UCSF Legacy ID
- thd83e00
Document Images
A STUDY OF THE RELATIONSHIP BETWEEN P53 MUTATION AND SMOKING IN
HUMAN NON-SMALL CELL LUNG CANCER
Li, J.H., Bi, X.J., and Peng, Z.H.
Department of Oncology, Nan Fang Hospital, First Military Medical
University, Guangzhou, China
A study was undertaken to explore the relationship between p53
mutation and cigarette smoking in human non-small cell lung cancer
(NSCLC) during 1992 to 1993. The p53 mutation of 52 patients with
pathologically proven NSCLC was assessed. In this group of 43
males and 9 females, the ratio of male to female was 4. 8 c 1, and age
ranged from 30 to 71 years old, with a median of 55. The
histopathologic categories of the cases were 30 squamous cell
cancers and 22 adenocarcinoma.
The detection of p53 mutations of all primary resected NSCLC
specimens was performed with immunohistochemistry. One patient
with adenocarcinoma had a mutated allele of p53. PCR-SSCP analysis
showed the p53 mutation to be in the region between exons 5, 6, 7
and'8. Sequence determination revealed that the 280 codon has been
changed from AGA to ACA.
Thirty-seven of 52 patients with lung cancer reported smoking
cigarettes, suggesting that the presence of lung cancer was
probably associated with smoking. However, in 25 patients with a
p53 mutation, the smoking individuals accounted for only 17 cases
(68%); in 27 patients without a p53 mutation, the smoking
individuals accounted for 20 cases (74%), a difference that was not
statistically significant (p=0.05). These results revealed that
the p53 mutation might not be closely related with smoking
cigarettes.
