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_. _CEIVED International Center for a Scientific c~~c~~y~Q93 L-".; t. J. PJELMES Mr Peter N. LEE Statistics and Cornputing Ltd Hamilton House 17 cedar Road SM2' 5DA Sutton, Surrey GRANDE-BRETAGNE Paris, March 31, 1993 Seminar of 10 May 1993 on the linear relationship Dear Professor Lee, i'shouid like to thank you~once again for participating and I am happy to confirmithe practical details for your participation in our seminar on 10 May 1993 in Paris, at the Hilton Hbtel, 18 Avenue de Suffnen, Telephone: (33' 1) 42 73,92 00, Fax: (33 1) 47 83 62 66. Firstly„the final Programme is as follows: Monday May 10, 1993 8.15/8.30 a.m. • Welcome address by Pierre Joly, Chairman of the InternationaliCenter for a Scientific Ecolbgy. 8.30/9 a.m. • Opening speech by Chairman of the Seminar, Prof. Bruce N. Ames (Biologist'4 Dir., Nat. Inst. of EnvironmentallHealth Sciences Center, Berkeley, U.S.A.). 9/9.20 a.m. • How biofogically based modeis may help extrapolating cancer risk to low doses. Prof.Georg Luebeck (Fred Hutchinson Cancer Research Center, Seattle, U.S.A.). 9.20/9.40 a.m. • Critical approach of mathematical extrapolation. Prof. Etienne Fournier (Toxicologist, Hopital Fernand-Widal, Paris, France): 9.40/10.00 a.rn. • Do rodent studies predict humanicancers?'Prof. Aaron Wildavsky (University of California, Berkeley), U.S.A.): 10.00/10.20 a.m. • The Delaney amendment and its consequences on the American regufation. Prof. S. Fred Singer (Physicist, former Dir., US Weather Satellite Program; President, Science & Environmental Policy Project, U'.S.A.). 10.20/10.30 a.m. • Coffee break. International Center for a Scientific Ecology 10, avenue de Messine. 75008 Paris, France Phone : 33 1 45 62 20 03, Fax : 33 1 42 89 00 159

10.30LNoon • Case studies: Predictions and reality. - The Arsenic case. Prof. Gerhard Stohrer (former chief, Dept!. of chemical risk, Research Inst. Sloan-Kettering~ U.S.A.). - The Asbestos case. Prof. J. Corbett MacDonald'. (Epidemiologist,, Research Unit in Epid_, Heart and Lung Inst., Londres„U.K.),. - The case of chlorine and derivated products (VCM). Dr Werner Freiesleben (Dir., European Council of Vinyl Manufacturers) The case of radiations. Prof. Bernard L. Cohen (University of Pittsburgh). The DDT case. Dr. William Hazeltine (Ph.D., entomo!bgist, former Manager of mosquito abatement in California, U!.S:A.). The Saccharin case. Prof. Clifford I. Chappel (Ontario„ Canada).. The case of passive smoking. Prof. P.N. Lee (Statistics and' computing, Sutton, U.K.): Noon/12:3& p.m. • Questions /, Answers. Discussion on reports. 12.30/2 p.m. • Lunch. 2/3 p.m. • Continuation of discussion on reports. 3/4.30 p.m. • General discussion 4.30/5 p.m. • Coffee/Tea break. 5/6p.m. • Carrying of a consensus text. End of Seminar. 6/7p.m. • Speciallrroeeting with international scientific press for QLA and interviews. Registration: The registration office will be open from 2 pm onwards at, the Hilton Hotel, on Sunday 9 May, to welcome you and assist you should you reqNire it. Please ask for Sophie Valtat who will be responsible for facilitating your stay in Paris and your participation in the seminar. Welcome cocktail party: This cocktail party is to allow panellists to get to know one another (or to meet up!) and to make contact with the International Centre directors and Seminar organisers. Meet in the lena room~(10th floor) of the Hilton Hotel at 7 pm.

Dinner: Panellists will meet at afrierldly~ informal dinnerstarting aU 10 pniin 1he Passy room (1'.Othiflbor). Monday 10 May at 8:15 am: The following speakers will take their places on~the platform:. Mn Pierre Jbly, Prof. Bruce N. Ames, Prof. Georg Luebeck, Prof. Etienne Fournier, Ptof. Aaron Wildavsky, Prof. S. Fred Singer and Dr Michel Salornon. 10:20 am (coffee break): The above speakers will take their seats on the floor, except for Prof. Bruce N. Ames, who is chairing the occasion. They will be replaced on the platfbrrn by: Prof. Gerhard'Stohrer, Prof. Corbett McDonald, Dr Werner Freiesleben, Dr William Hazeltine; Prof. Bernard L. Cohen, Prof. Cliffbrd Chappel and! Profl P.N. Lee. Afternoon session (2 pm to 3' pm): Questions will be posed exclusively by the panellists (invited industrialists or government representatives will not take part), and replies will be made by the morning, speakers, depending on the nature of the questions. Gener& discussion session (3 pm to 4:30 pm): Discussion open toiall panellists wishihg to take part on the general': theme, in the light ofithemorning expositions: "7s the concept of linear relationship between dose and effect still a valid model for assessing risk related to low doses of carcinogens?" Consensus session (5 pm to 6 pm): Discussion on the basis of a draft text prepared by Profs. Bruce N. Ames and S. Fred Singer, and Dr Michel'.Salomon. Adoption of a final text. Press conference (6 pm to 7 pm): The whole Panel will receive the representatives of the international scientific press. Ihtroduction by Dr Michel Salomon, summary of seminar by Profs. Bruce Ames and S. Fred Singer. Questions and answers. Dinner (7:30 pm to 9 pm): Panellists will attend the dinner off'eredby the International Centre for Scientific Ecology (Passy room, 10th flbor). ) We hope that'this programme suits you. Do not hesitate to make any observations to us should you so desire. I am delighted to~welcome you to Paris for this first meeting organised by our Centre, and Il am convirnced that, thanks tb your eminent participation, we shall have a meeting ot greatscientific quality. Micheli Salono3h, M.D. International Center for a Scientific Ecology 10, avenue de Messine, 75008 Paris, France Phone : 33 145 62 20 03, Fax : 33 1 42 89 00 59