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FTR SCIENCE AND TECHNOLOGY P.O. Box CH-2003 Neuchatel /' Switzerland INTER-OFFICE CORRESPONDENCE To : Mr. S. PARRISH From : H.W. GAISCH Subject : MONTHLY REPORT H I G H L I G H T S COPIES TO:: Mr. W. THOMA Mr. M.D. HORST Mr. H. BRASS Mr. R. LIVELY Dr. M.C. BOURLAS Mr. S. CARLSON Ms. C. PURCELL Mr. A. ANDRADE Abbreviations : ANB = A. BADSTUBER HER = H. REIF HGA = H.W. GAISCH IAM = I. MARCOVITCH MJA = J.C. MAN!DIRATTA Date : 20th December, 1991 D E C E M B E R 1 9 9 1 Mr. A. GEMBLER Mr. F . H . DU!LLES Mr. A.G. BUZZI Dr. T.S. OSDENE Mr. D:. MILBY Dr. R. PAGES Mr. J. SCHARDT MPO = M. POLAK PEM = P. MARTIN PIC = P. CESCHINI RDE = R. DEMPSEY RIT = M. RITTER For further information, please contact S&T Neuchatel TEL : 41 38 31 81 71 FAX : 4'1 38 31 24 76

M-REP December, 1991 - 2 - Visits/Contacts made by S&T staff : Belgium, England (1) -SCIENTIFIC BRIEFINGS MEDIA WORK : S&T presentations were given to a group from! Finland!, representing the government, the hotel and food industries and~ the trade unions, and to the Sales Director of Intertaba. (2)-EXTRAMURAL PROJECTS, PRIMARILY IAQ EXPERIMENTAL WORK - PRESENT STATUS : - IMPERIAL COLLEGE, LONDON - IAQ IN UK OFFICES - OBJECTIVE : TO SUPPLEMENT'THE BASIC RESULTS OF THE "PERRY STUDY" WITH SOME MORE DETAILED AND REFINED INVESTIGATIONS (e.g,. THE TIMEWISE CHANGE' IN IAQ). STATUS : The measurements for the summer period are now finished and are being evaluated. The measurements for the winter period are currently being made. The whole operation is not facilitated by the fact that Imperial College, as a whole, was declared non-smoking as of October and Prof. PERRY's department had~ to apply for a special permit. - FRESENIUS - METHODS FOR IAQ MEASUREMENT - OBJECTIVE : TO DEVELOP EQUIPMENT (NON-OBTRUSIVE AND LABORATORY TYPE), AND METHODS TO MEASURE A WIDE VARIETY OF IAQ PARAMETERS. STATUS : The following work remains to be done on the portable samplers: (1) a thorough check of all functions, (2) production of technical manuals, and (3) an official certificate showing that they can be used aboard airplanes without creating electromagnetic interference. - NEURATH - VENTILATION REGIMES - OBJECTIVE : TO STUDY' HOW IAQ IS INFLUENCED BY DIFFERENT TYPES OF VENTILATION, AND THEIR CONCOMITANT EFFICACIES. STATUS : The achievements of this project were discussed with Dr. NEURATH during his visit to S&T. According to the contract the project'continues into 1992, but it is currently under review.

M-REP December, 1991 - 3 - - INBIFO - HUMAN CONTRIBUTIONS TO STALE AIR - OBJECTIVE : TO RELATE STALENESS OF AIR TO HUMAN METABOLIC COMPOUNDS. STATUS : The human metabolic pathway for the production of dimethyl sulfone does not seem to have been published. A publication is now planned on the existing results from this project. - SCHNEIDER - COMPARING RISK FACTORS IN THE MODERN ENVIRONMENT' - OBJECTIVE : TO INVESTIGATE' AND ANALYSE MATHEMATICAL MODELS FOR RISK ASSESSMENT' UNDER COMPETING RISK FACTORS AND CONFOUNDING CONDITIONS. STATUS : A proposal for changes in the computer programme has beeni sent to Prof SCHNEIDER for implementation,. The next discussion is foreseen for January 1992. - FRESENIUS - NICOTINE AND RELATED ALKALOIDS IN FOOD - OBJECTIVE: TO CHECK A VARIETY OF WIDELY USED FOOD AND SPICES FOR THE' PRESENCE OF' NICOTINE, NORNICOTINE, ANABASINE' AND COTININE, AND TO DETERMINE THE AMOUNTS QUANTITATIVELY. STATUS' : The final report on all spices, teas and vegetables tested is still pending. - LEE / GARDINER - AVIAN CONTACTS AND RELATED DISEASES - OBJECTIVE : TO DEVELOP QUESTIONNAIRES AND CARRY OUT INTERVIEWS TO OBTAIN INFORMATION ON THE INFLUENCE' OF CONTACTS WITH PET BIRDS IN THE' DEVELOPMENT OF LUNG DISEASES. STATUS : The final report is still pending. - WEETMAN - REVIEW OF ASSUMPTIONS MADE BY TECHNICAL COMMITTEES WHEN DECIDING ON 'SAFE' EXPOSURE LEVELS - OBJECTIVE : TO IDENTIFY THE SETS OF ASSUMPTIONS USED BY VARIOUS TECHNICAL COMMITTEES IN SETTING 'SAFE' LEVELS OF EXPOSURE TO PUTATIVE INDUSTRIAL HAZARDS. STATUS . No new developments to be reported. - TNO - ODOUR TRAPPING BY MEMBRANE FILTRATION - OBJECTIVE : TO REMOVE' GASEOUS •TOBACCO SMOKE COMPONENTS EFFECTIVELY' FROM A SMOKE-LADEN ROOM. STATUS . The final report on the N Q N X );k ~ N ~ ~

M,REP December, 1991 - 4 - optimisation of the technical parameters, and the hardware used for filtration, showed extremely promising results. (3)-PATENTS : APPARATUS FOR EXTRACTING SOLUBLE CONSTITUENTS FROM CUT PLANT' MATERIAL - FTR1025 Patent No. 00 57 979. The R&D Process Development Department has decided to abandon this case by not paying the renewal/maintenance fees for this case. CIGARETTE PACKET WITH ROUNDED EDGES AND CONVENTIONAL LID - FTR0069 U.S. Design Patent Application No. 07/095,243. We have received an Issue Notification from the United States Patent and Trademark Office (USPTO) stating that this design application will be issued in December 1991 as U.S. Patent No. Des. 322,687. DISPLAY PACK - FTR0087 U.S. Design Patent Application No. 07/363,944. The USPTO has granted this Design Patent Application and has issued it under the No. 321,134. CONCENTRIC FILTER CIGAR:ETTE - FTR0091 U.S. Patent Application No. 07/508,933. Fish and Neave (~F&N) has filed the Response to the final Examiner's Action in the USPTO. Finnish Patent Application No. 90 1884. Our associates will reply to the official letter which asked for the results of searches in other countries. Norwegian Patent Application No. 89 1988. We have accepted the amendments proposed by the Examiner and the application should now proceed to acceptance and grant. AUTOMATIC SORTING SCALE - FTR0093 U.S. Patent Application No. 07/582,087. We will respond to the further Examiner's report O by the due date. ~ Gn 4~lh METHOD AND APPARATUS FOR FORMING CONTINUOUS CIGARETTE RODS - ~ FTR0095 U.S. Patent Application No. 525,702. We have N instructed F&N to remit the Issue Fee within the given term so O that this application can mature into a patent very soon.

M-REP December, 1991 - 5 - CONTROL PROCESS AND APPARATUS FOR THE PRODUCTION OF CIGARETTE FILTERS - FTR0097 U.S. Patent Application No. 0~7/553,117. The response to the Examiner's Action and Information Disclosure Statement was filed in the USPTO:. METHOD FOR CHECKING FOR PROPER HOOK-UPS IN A TUBING SYSTEM - FTR0099 U.S Patent Application No. 07/580,311. The draft response to the Examiner's Action has been reviewed and F&N has been instructed to file the same in the USPTO. Australian Patent Application No. 62354/90 Our associate in Australia has filed a request in the Patent Office for an examination of this application. BACTERIAL CONTROL OF CIGARETTE BEETLES - FTRO100 New Patent Application in Turkey. This new application was filed claiming priority from the U.K. application. METHOD AND APPARATUS FOR SPLICING REELS OF PAPER - FTR0105 U.S. Patent Application No. 07/743,121. We have received the Notice of Recordation stating that the assignment has been recorded by the Assignment Division of the USPTO. DEVICE FOR CHECKING A STREAM OF TOBACCO BEFORE TRIMMING - FTR0108 U.S. Patent Application No. 717,937. The draft of the response to the first Office Action was approved and sent to F&N for filing im the USPTO. TRIPLE TUBE-IN-TOW FILTER - FTRO110 New U.S. Patent Application. The USTPO has issued a Filing Receipt stating that this application has been assigned Serial No. 07/767,157, andalso a Notice of Recordation of Assignment document. The Information Disclosure Statement has been filed in connection with this case disclosing the references to the USPTO. FLAT CARTON I and II - FTR0114 U.K. Registered Design Application Nos. 201 1065 and 201 1066. We have received further objections from the Design Registry and we are preparing the answer in time for the due date.

M-REP December, 1991 - 6 - METHOD AND APPARATUS FOR ADHERING PACKS FOR SMOKING ARTICLES - FTR0115 New U.S. Patent Application. Based on U.K. Patent Application No. 90 27 833.4 this new U.S. application has been filed in the USTPO. PROCESS OF APPLYING ADHESIVES ON PAPER - FTRO118 Swiss Patent Application No. 553/91-0. The European Patent Office has issued the International Search Report. All the references are merely regarded as technical background. CIGARETTE SEAM ADHESIVE - FTR0120 Polish Patent Application. The Patent Application was published~ by the Polish National Patent Office. PROCESS AND DEVICE FOR PREPARING BLANKS - FTRO122 Swiss Patent Application No. 1468/91-3. We have received' the result of the International Search Report. All references are merely regarded~as technical background. GRASPING AND TRANSFER DEVICE - FTRO123. New U.S. Patent Application. The USPTO has issued a Filing Receipt and assigned the serial number 07/777,732 to our application. PROCESS AND DEVICE FOR SUPPLYING A MACHINE WITH CIGARETTES. New Swiss Patent Application. The Swiss Patent Office has issued a Filing Receipt and assigned! the Application No. 3081/91-0. BAT SWISS PATENT'NO. 664.876 - BAT EXTRA SLIM CIGARETTES. We have received the preliminary decision from the Geneva Court of Justice of 25th October, 1991. The court simply copied all questions submitted to the experts by FTR and BAT. Furthermore, in accordance with: what we had! asked, the court ordered the experts to hear both parties after they have responded to the questions. The next hearing was fixed for 15th May, 1992. PAYNES' EUROPEAN PATENT No. 0121371. SUPASTRIP, SELF ADHESIVE TEAR TAPE. Paynes of Nottingham~ has informed us

M-REP December, 1991 - 7 - that we may be infringing their patent if we use pressure-sensitive tear tape from any source other than Paynes or its European licencee (Tann). In collaboration with our associate in the U.K. we are examining the present situation. POTENTIAL LICENCE AGREEMENT WITH F0CKE' - FTR European Patent. Application No.354 873. our associates in Germany have g,ivem us their comments on whether there is a possible infringement of BAT German Patent No. 3718'601 with this case. The same were forwarded to the Development and Technical Department of FTR for the final decision. (4)-WEEKLY HIGHLIGHTS : Tuesday, 3rd' : PIC / ANB - A presentation was given to Mr. ZACCHEO, the new Sales Director of INTERTABA (Bologna, Italy), on the activity of Science & Technology. After discussions, he was shown the video "Why People Smoke"',, as well as an excerpt fromi a Swiss TV newscast relating the atmospheric pollution to the lung cancer rate in Europe. Wednesday, 4th : HER - We received a report oni the regional WHO meeting on "Public Health in the Year 2000", which was held in Kiel, Germany between 18th and 21st November, 1991. The purpose of this conference was to analyse existing models of public health; to define the functions and tasks of public health and to develop public health at national and international levels. The topic of the same conference for 1992 will be "'Cost and Efficiency of Public H'ealth". The information we received' came from one of the participants at the meeting. PEM - At the request of C. LISTER, C&B, met with him and Prof. NILSEN, (University of Trondheim) in Basle to discuss the current status and future plans for the project involving hair nicotine measurements. Wednesday. 11th : HGA / HER - Gave a presentation~ to a group of Finns, namely Messrs. PEKKA HAEMAELAE:INEN - Managing Director of Finnish Food Industry's Federation and Managing

M-REP December, 1991 - 8 - Director of Finnish Food Industry, JUHANI HOPSU - Deputy Managing Director of Hotel, Restaurant and Cafeteria Association, TAPANI KASSO - Political Secretary of the Minister for Foreign Trade, PAULI KAKKO - Secretary of Social and International Affairs of Finnish Food Workers Trade Union, EERO HEINAELOUMA - Planning Secretary of SAK (The Federation of Finnish Trade Unions) and Political Secretary of Mr. LAURI THALAINEN (SAK's Chairman), LASSE' LEHTINEN - Senior Vice-presid'ent, Corporate Affairs, Amer Group Ltd~., KALLE SOIKKANEN - Legal Advisor, Corporate Affairs, Amer Tupakka. These gentlemen were accompanied by JOHAN PUOTILA - Manager Corporate Affairs PM AB, Stockholm. The main~ topics of the presentation were a)~-Considerations of Health and' Comfort, b)-Important Aspects of Air Quality, c)-The Technology of Ventilation~, d') Practical Solutions, e)-General Discussions.. Thursday, 12th : HGA / HER / IAM : Co-ordination meeting on programmes concerning long-standing S&T objectives and their integration with~ the prime objectives of the two~ European regions for 1992, ie. 1) taxation and tariffs, and~ 2) freed'om of advertising and promotion. The participants were Messrs. A. ANDRADE (LEGAL), J.-B. BODER (R&D), U. CRETTAZ (FTR), G. DISERENS (EEMA),, W. FINK (R&D)., M. HORST (EEC)', R. MAY (EEC), R. PANTET (FTR) and K. WARE (EEC),. Messrs. S. CARLSON and P. GRANDJEAN (CA EEMA) had a last-minute conflicting commitment and! sent an apology. The next meetingg will be held on 22nd January, 1992, in Lausanne. PEM - Attended the meeting: of the Scientific Committee of TAC with the ISCSH. The principal topics discussed were the future of the research programme of the Tobacco Products Research, Trust (TPRT), and a list of permitted additives for the UK in light of the EC harmonisation. After reviewing the state of the research, programmes Sir PETER FROGGATT stated that although the ISCSH will cease to exist at the end of this year, further TPRT grants may be awarded, and would be adtninistered by those continuing with the TPRT' (certainly Prof. D. POSWILLO and Ms. C. SWANN). Sufficient money had been, put aside to cover either a monograph, or a conference, summarising the TPRT programme on its completion, and he felt that either the

M-REP December, 1991 Chairman of any future ministers, or himself summary. He said he - 9 advisory committee appointed by thee had responsibility to produce this had no information on a replacement committee at this time, but felt a decision was likely within 3-6 months. Monday, 16th : HGA - Meeting, in London with Messrs. ANDRADE, PECK and NEWSOMi (SH&B), on coordinating on,going contacts with scientists throughout Europe. Second meeting with Mr. LISTER, (C&B), to discuss the progress of the ETS research and consultants projects. Third meeting with Messrs. PALIN' and REDFERN on various communication projects. HER - Meeting with, Drs. LAZAR HERZFELD and WALTER STOECKLIN of Herzfeld Laboratories, Basle, Switzerland~. Dr. HERZFELD is well-known in Europe for the development of the "Herzfeld Index'"' for cigarette deliveries. He tried to compress several parameters (tar, nicotine, gas phase components) into a single figure which was then used for cigarette ranking. The two gentlemen reported on their progress in establishing a standard method for a complete chemical characterisation of liquorice. inTednesday, 18th : PIC - Meeting at CERIA with Prof. J. LENGES, Director of the "Station d'Essais", his assistant, Ms. L. DEWEGHE, and Ms. I. VANDERPUTTEN, a co-worker. The aim of the visit was to discuss the results of the preliminary study of the air quality in Belgian railway carriages. They were also informed~ that it had been decided not to pursue this project_ Thursday, 19th . HGA / HER - Hosted Dr. GEORG NEURATH to discuss the ongoing project. He presented a report on the last three years of contractual research in the field of ETS and improvement of ventilation. All his experiments were done in a highly efficient laminar flow chamber with remote-controllied on-line instrumentation,, and he provid'ed' a draft version of a progress report. this facility was discussed. Possible future use of N 0 N ~ N N ~ ~