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s AGENDA Monday May 10. 1993 - The Saccharin case. Prof. pitfnrd L qhappel (Ontario. Canada). - The case of passive smoking. Prof.P.N. Lee 8/8:15 a.m. • Registration - Coffee. . (Statistics and computing. Sutton. U.K). 8.15/8:30 ~a.m. • Welcome address by Pienre Joly, Chairman Noon/12.30 p.m. • Questions / Answers. Discussion on reports, .30/9 a.m. of the International Center for a Scientific Ecology. • Opening speech by the Chairman of the 12.30/2 p.m. • Lunch. _ 2/3 p.m. • Continuation of discussion on reports. /920 a.m. Seminar. Prof. Bruce N. Ames (Biologist, Dir. AJat: Inst of Environmental Health Sciences Center.. Berkeley. USA).. • How biologically based models may help 3/4.30 p.m. • General discussion. 4.30/5 p.m. • Coffee/Tea break. 5/6 p.m. • Carrying of a consensus text. .20/9:40 ~a.m. extrapolating cancer risk to low doses. Prof. Georg Luebedc (Fred Hutchinson Cancer Research Center Seattle. US.A). • Critical approach of mathematical End of Seminar. 6/7p.m. • Special meeting with internationall scientific press for Q/A and interviews. extrapolation. Prof. Etienne Foumler (Toxicologist Hopital Fernand-Widal: Paris. France). • 9.40/10:00 a.m. • Do rodent studies predict human cancers ? Prof. Aaron Wlldavsky (University of California, Berkeley, USA). Participants to the sdentific Panel Invitations have been sent to a number of distinguished 10:00/ 10.20 a.m. • The Delaney amendment and its consequences on the American regulation. international scientists. We expect twenty to thirty scientists to attend. Prof. Fred S. Singer (Physicist, forrner Dir. US Weather Satellite Program : President Science Audience & Environmental'Policy Project. USA). A number of personalities from industry and administrations will 10:20/ 10.30 a.m. • Coffee break. attend the Seminar as observers. Their financial contribution• making the meeting possible. 10.30/iVoon ~ • Case studies : Predictions and reality. The Arsenic case. Prof. Gerfiard StBhrer (former chief Dept, of chemical risk Research lnst: Sloan-Kettering. USA.). - The Asbestos case. Prof. J. Conbett McDonald (Epidemiologist. Resean:h Unit in Epid.. Heart Organisation The Seminar is organised~ by the International Center for a Scientific Ecology (see introduction to the Center in cover page). The scientific work is organised by Dr Michel Salomon. Coordinator of the Heidelberg Appeal! and Lung Inst., London. U.K). Translation - The case of chlorine and derivated products (VCM). Dr Werner Frelesleben (Dir. European Council of Vinyl Manufacturers. Beussels. Belgium). Lectures and comments may be either in English or French, Simultaneous translation will be provided in both languages throughout the Seminar. - Ttie DDT case. Dr William HazeiHne Press Conference (Ph. D., entomologist, former Manager of mosquito abatement' in Califomia. USA). - The case of radiations. Prof. Bernard L Cohen (Universityy of Pittsbwgh). International Iscientific journalists are asked to register if they wish to attend the sessions. A press conference will be held by the members of the scientific panel at 6 p:m. on May 10. 1993.

THE INTERNATIONAL CENTER - FOR A SCIENTIFIC ECOLOGY The Centerfias been created at the beginning of 1993 under the French law for non-profit organizations. The purpose is to answer the request from a number of the Heidelberg,Appeal signatories in view to extend its impact in examining actual issues the scientific community is confronted with. The purpose of the Center is expressed in the by-laws : 'The purpose of the Association is to promote and facilitate exchange of scientific knowledge: based on scientific data. regarding the protection of mankind: other living species. naturaf sites and the resources of the pfanet. The Association thus proposes to provide the most relevant scientific facts to the authorities responsible for developing environmental protection policies. to the Society which, under the principle of transparency. is called upon to express its point of view, as well as to all socio-economical partners who want to contribute in both the conservation of the Earth and the long-term deve!opment of its populations.- The Board of the Center inclUdes inparticular: - Mr Pierre Joly, President of the Association Francaise pour la.Recherche Therapeutique : former President'~ of the International Federation of Pharmaceutical Manufacturers Association :. - Mr Constant Burg. honorary member of the State Councill: honorary managing director of,INSERM : President of the Institut Curie : - Mr Gilbert Rutman, chief mining engineer ;,President of the ConseillNational des ingenieurs et des Scientifiques de France : - Prof. S. Fred Singer. Doctor of Physical Science : President of the Science & Environmental Policy Project : former Direct'or US Weather Sat'ellite Program : Dean of the School of Environmental Sciences. University of Miami : Deputy Assistant Administrator of US Environmental Protection Agency (EPA)l: - Mr Gary Nash. Secretary Generallof the International Councili on Metals and the Environment (ICME) : former Director General in the Canada Department of Energy. Mines and! Resources : - Dr. Michel Salomon, coordinator of the Heidelberg Appeal : former science journalist : magazine editor. The Seminar devoted to the linear dose/response relationship Is the first event initiated by the International Center for a Scientific Ecology. International Center for a Scientific Ecology Centre International pour une Ecologie Scientifique Is the concept of linear relationship between dose and effect still a valid model for assessing risk related to low doses of carcinogens ? An international scientific seminar organized by the International Center for a Scientific Ecology May 10, 1993 - Paris (France) (Hilton Hotel, 18. Avenue de Suffren - 75015 Paris). Under the patronage of the follbwing Associations : • The Science and Environmental Policy Project' • Entreprises pour i'Environnement ~ Conseil National des Ingrsnieurs et Sdentifiques de France International Center for a Scientific Ecology 10. avenue de Messine. 75008 Paris, France Phone : 33 1 45 62 20 03; Fax : 33 1' 42 89 00 59