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Philip Morris

International Center for A Scientific Ecology Guidelines for the Seminar on Linear Relationship for Risk Assessment of Low Doses of Carcinogens

Date: 02 Oct 1993 (est.)
Length: 1 page
2028385372
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Type
REPT, REPORT, OTHER
Area
REIF,HELMUT/OFFICE
Named Person
Cohen, S.
Freiesleben, W.
Lee, P.N.
Macdonald, C.J.
Stohrer, G.
Request
Stmn/R2-038
Master ID
2028385369/5380

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Author (Organization)
Intl Center for A Scientific Ecology
Site
E5
Date Loaded
05 Jun 1998
UCSF Legacy ID
eek56e00

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Page 1: eek56e00
18/03 ' 9S 18: 02 1232 2 2878069 P.1[. C. S BRUSSELS +" FPR Neuchatel CH W004/012 International Center for a Scientific Ecology GukWhum i6or the secad= an 1'u~ear n~2lat~hip for:3skare-- emotaEbw domotc~u~og~s The mornfng of tha sttmfnur will be devoted to curnmunications on the fvllowing topics: methodology of predictive studies bas.d on the linear relationship concept applied to low-level .xposure to carcinogens; studies of epectfic ceses; • uuLutoa (Yro1: J. Corbett MacDonald); • arsenic (Prof. Gerhard Stahrer); • vis~1 chloride monomer (VCM) (Dr. Warner Freiesleben); • saccharin (Prof Samuel Cohenl; • passive smoking (Prui` P. K. Lee). T'hese case studies ars intended to shvw wbrsther there are any sipnff'usnt correlations between farecasts based on the linear relationship principle and the facaa or data Available (clinieal and statistical aspeets) which can be observed today. ThesQ six substances have been selected on the basis oYtha Lollowing criteria: tbeir diversity of action; suf'Sdent follow-up time to permit in-situ observation; thQ difficulty of evaluat3ng the effects of low-level exposure using conventional epidemiologlcal methods. With tbis in mind, we th9ak it would be a good idea if all our epQalers could include the followirtg points: • dose levels below which conventional epidemiology ceases to be applicable (cohort size, cost, time required); • mortaiityprediCtion based on linear mal.heniatical extrapolation; • clinical observations in keeping with the forecasts darived from mathematiml. extrapolations. • evaluation of t6 dev'sations; • a descfriptio», if appropriate, of'the regulatory response to these forecasts, their Wsi,ts in terms ot public health and of thc economic and social costs; • risk9/benefit caasiderduas; • the opeaker's personal conclusions. ln order to allow sufficient time for discussion with the scientific panel, we propose the following two-phase schedule: 1• Submission of a written report (10/15 pages, including the bibliography). This paper which should be in english, wi31 be circulated to all panel members. Closing date for submitting texts : April 10, 1993. , 2. A ten-minute oral communication given on May 10, 1993. An abstract focussing on the conciusions of your written paW. Tf thern is anything which is not clear to you, please to not hesitate to ask us about iti J1araaewIcnJaNrss Fax: (881) 42 89 00 69 2OZ9385372 emafionol Cerner tor a SciMihc Ecoiogy IO, avenue de Noslne, 75008 Pais. France Yel; 3314562 20 03. Fax :33 1 42 89 03 59

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